WO1989012473A1 - Preloaded automatic disposable syringue - Google Patents
Preloaded automatic disposable syringue Download PDFInfo
- Publication number
- WO1989012473A1 WO1989012473A1 PCT/US1989/002689 US8902689W WO8912473A1 WO 1989012473 A1 WO1989012473 A1 WO 1989012473A1 US 8902689 W US8902689 W US 8902689W WO 8912473 A1 WO8912473 A1 WO 8912473A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- housing
- syringe
- cylinder
- annular
- ampoule
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
- A61M5/282—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
- A61M2005/14252—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
- A61M2005/1426—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with means for preventing access to the needle after use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/206—With automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
Definitions
- This invention relates to a hypodermic medicinal injector and, in particular, to a hypodermic syringe which is safe and capable of one time use by patients, handicapped, totally blind or aged persons and children.
- Medi-Jector Easy is promoted as a needle-free, insulin injection system. While this device avoids the use of injection needles, it is intended for use by medically trained personnel to maintain proper sterility, and it is not a disposable injection system that can be readily used by patients, or incapacitated persons.
- Inject-Ease Another device which has been recently introduced is marketed under the name Inject-Ease. This device uses a hypodermic needle and has interchangeable spacer rings to control the depth of needle penetration. None of the devices currently marketed provide a disposable needle type syringe for application of medication which is safe, sterile and is adaptable for use by patients, including children and handicapped and elderly patients. In many applications, there is no current substitute for administration of medication by medically trained and skilled persons, since there is no syringe which heretofore has been available with accurately measured dosages of medication, and which can be used by the patient. Thus, diabetic patients, or patients suffering chronic allergies, must be dependent upon receiving medical attention and care for administration of medication.
- a syringe for use by patients must be disposable, with a design which will prevent reloading, thereby avoiding misuse of the syringe and the possibility of cross infection with agents such as AIDS viruses.
- the hypodermic needle of the syringe should be totally protected from contamination, and the syringe should be capable of mass production, thereby insuring its low cost. It is a desirable objective, at this time, to supply the syringe with variable size needles from 1/8 to 1/4 inch and of 23 to 30 gauge, for pediatric, adults and obese patients. It is also an objective to provide a syringe which is preloaded by a licensed pharmaceutical company, insuring sterility and accuracy of dosage and strength of the medication.
- This invention comprises a pre-charged, disposable syringe capable of use by patients.
- the syringe includes a housing with a cover having a central aperture which receives an actuator button.
- the actuator button extends to an internal piston which is mounted over a medication ampoule.
- the ampoule has a dependent hypodermic needle which is slidably received in the housing for movement between recessed and projected positions. In its recessed position, the ampoule is totally contained and supported within the housing, and in its projected position, the hypodermic needle projects out of the housing.
- the housing contains an actuator spring, which is compressed and biased to move the piston and the ampoule into its projected position.
- the medication is discharged from the ampoule by the mechanically coupled piston, or by the release of air from an internal air pressure chamber.
- the actuator button is locked for safety with a detent and plastic ring and is covered with a protective, removable cap to prevent accidental or unintended injection of the medication.
- FIGURE 1 is an exploded perspective view of the air activated embodiment of the invention
- FIGURE 2 is an elevational sectional view of the embodiment of FIGURE 1, fully loaded in a static, preactivated state;
- FIGURE 3 is a partial, elevational sectional view of the embodiment of FIGURE 1 is its discharged state;
- FIGURE 4 is a perspective view of the assembled and loaded syringe of the invention;
- FIGURE 5 illustrates removal of the protective tape from the underside of the syringe;
- FIGURE 6 is a view of the syringe, uncovered, and in a position to inject its medication
- FIGURE 7 is a view of the syringe after use, with the cover replaced on its undersurface for disposal;
- FIGURE 8 is an elevational sectional view of a spring activated mechanism, in a static, preactivated state; and FIGURE 9 is an elevational sectional view of the device of FIGURE 8 is its discharged state.
- FIGURE 1 the invention is illustrated in exploded view.
- the particular embodiment illustrated in FIGURE 1 is the air activated device.
- the device has a housing 10 which is preferably cylindrical of relatively low height or elevation, and has a central cavity 12 which receives the operating mechanism.
- the central cavity 12 has an internal well 14 with a right-angle, vertical cylindrical wall 16 which slidably receives a cylindrically shaped ampoule member 18.
- the ampoule member 18 has a hypodermic needle 22 that extends through its under surface and communicates with the medication chamber, described in greater detail with reference to FIGURE 2.
- An annular groove 26 is provided about the outer side wall 28 of the ampoule 18 which is engaged by a sealing plastic ring (shown in FIGURE 2) .
- the upper end of the sidewall of the ampoule 18 has an annular recess 32 which serves as a chamber for housing a compression spring (also shown in FIGURE 2) .
- the actuator button 33 has a central upright boss 34 which is received in the central aperture 36 of the cover 40.
- the button 33 and has a circular base 44 which carries, on its undersurface, a knife 42 having a circular blade.
- the housing 10 has an outer annular chamber 43 which is the air supply chamber for the mechanism.
- a fill port 46 is provided in the upper wall of the air chamber and this port 46 communicates with an aligned aperture 48 in the cover.
- a pneumatic valve 50 is inserted in the aligned aperture 48 and fill port 46.
- This valve 50 is of a general grommet-shape with a through passage 52 that is normally sealed by the resilient deformation of the valve member under the internal pressure within the air chamber.
- the internal air chamber communicates with the interior, medication chamber 24 through a valve 54 which is sealed by a plastic ring 56.
- the valve has an annular seat 58 and is entirely covered by this plastic ring seal 56.
- the seal 56 is received in annular groove 26 about the ampoule member 18, and thus also serves as a detent to restrain the ampoule member 18 and needle 22 within the housing.
- Seated within the medication chamber 24 is the cylindrical cup-shaped ampoule member 18 which supports the hypodermic needle 22 on its under surface.
- the hypodermic needle 22 is aligned with a central through aperture 60 in the bottom wall 62 of the housing 10 and is of sufficient length that when the ampoule member 18 is in its illustrated, retracted position, the hypodermic needle 22 is withdrawn from this aperture 60.
- the ampoule member 18 has sufficient travel within the housing 10 to project the needle 22 through the aperture 60 and a predetermined distance into the tissue of the patient.
- the actuator button 33 has a central raised boss 34 that extends through the central aperture 36 of the cover 40.
- the button 33 is enclosed within a protective cover 38 which seats against an annular rim 39 about the mid-portion of the housing 10.
- the cover 38 can be sealed to the housing by a tear tape, if desired.
- the button 33 supports, on its undersurface, a knife 42 with a circular blade.
- the knife blade has a sharp circular cutting edge 66 which is aligned with the plastic ring 56 so that it will puncture this plastic ring and permit the discharge of the pressured air from the annular air chamber 43 past the valve and into the ampoule chamber.
- the knife also has a circular groove 67 which communicates with a passageway 69 that extends into communication with the internal chamber 24 of the ampoule member 18.
- the ampoule member 18 has an annular well 32 in its upper edge which provides a chamber for the actuator spring 70.
- the actuator spring 70 is a compression coil spring biased between the undersurface of the button 33 and the bottom wall of the annular well 32. This spring has sufficient strength and resiliency to advance the ampoule member 18 instantaneously upon release of the detent, previously described, and extend the hypodermic needle 22 through the frangible sterile tape 72 on the undersurface of the housing and into the patient's subcutaneous space.
- the extended positions of the ampoule member 18 and needle 22 are shown in FIGURE 3. This extension of the ampoule member 18 and hypodermic needle 22 occurs sufficiently rapidly to precede the application of air pressure through circular groove 67 in the knife 42 and the passageway 69 of the button.
- the needle 22 is extended before air pressure is applied to the ampoule 74 contained within the ampoule chamber 24.
- the ampoule 74 is formed by an elastic balloon which is received within and sealed to the inner walls of the ampoule chamber, containing medication 78 within its sealed interior.
- the air pressure supplied by the air chamber 43 through the air valve 54 and into the ampoule chamber is sufficient to collapse the medication balloon and inject the medication 78 contained within the balloon into the patient.
- FIGURE 4 illustrates the hypodermic syringe of the invention as it would be received by the patient.
- the syringe is preloaded with a precisely measured dosage of medication and has the proper selection of needle size for the patient. All of this information can be coded on the syringe itself.
- the protective cover 38 overlies the actuator button 33, and must be removed by the patient for access to the button.
- the patient or user will first remove the protective overlay tape 80, exposing the underlying frangible, sterile tape. As shown in FIGURE 6, the patient will then position the syringe against a suitable skin surface.
- the undersurface of the housing and the sterile tape 72 is coated with an antiseptic pressure sensitive adhesive so that, when placed on the skin of a patient, the undersurface of the device will disinfect and be slightly tacky and will stick to the skin of the patient.
- the patient then depresses the actuator button 33, breaking the detent of the plastic ring 56. This will release the spring 70 to advance the knife 42 through the plastic ring 56, and permit the ampoule member 18 to be ejected into its extended position.
- this device 82 has a cylindrical, cup-shaped housing 84 having an outer wall 86 defined by a right-angle cylindrical wall, and a central lesser diameter well 88.
- the bottom wall 90 of the housing 84 has a central through aperture 92 which slidably receives the hypodermic needle 94.
- the ampoule member 96 is a cylindrical cup-shaped member which contains medication 98 and which also receives a slidable piston 100.
- the piston 100 engages the inside wall of the cylindrical member 96 in a sliding seal which prevents leaking of the medication from the ampoule member 96.
- the ampoule member 96 is resiliently biased into its retractable position by a helical coil spring 102 which is seated in the central well 88 of the housing and which is collapsed when the ampoule member 96 is driven into its extended position.
- the actuator button 104 is slidably received in a central aperture 106 of the top cover 108.
- the actuator button 104 is restrained to this cover by a detent 112 formed by an annular groove 114 about its outer, upper wall in which is seated a resilient clip washer 116.
- the button 104 has a cylindrical skirt 118 and a single, outwardly flared flange 120.
- the cover 108 has a central inwardly and downwardly dependent skirt 122 which receives the cylindrical skirt 118 of the actuator button 104.
- a cylindrical boss 124 is downwardly dependent from the undersurface of the button 104 and has a diameter to permit it to be received within the ampoule member 96.
- the boss 124 is immediately above, and attached to, the piston 100 which is slidably contained within the ampoule member 96.
- An actuator spring 128 in the form of a compression coil spring is resiliently biased between the undersurface of the cover and the upper surface of the flange of the actuator button. When the device is in its armed and loaded condition as illustrated in FIGURE 8, the actuator spring 128 is compressed.
- the patient removes the protective overlay tape 130 from the undersurface of the device, in the manner previously described and illustrated in FIGURE 5.
- the undersurface of the device has an antiseptic, pressure sensitive coating permitting its application to the skin of a patient.
- the device is ready for injection of the medication which is contained within the ampoule member 96.
- the patient presses on the actuator button 104 sufficiently to override the resilient detent of the circular clip washer 116. This permits the actuator spring 128 to be released, forcing the ampoule chamber 96 outwardly into its extended position, which is shown in FIGURE 9.
- the ampoule needle 94 projects through the skin of the patient.
- the actuator spring 128 continues the travel of the actuator button, and advances the piston 100 through the ampoule chamber 96, ejecting the medication 98 in this chamber through the hypodermic needle 94, into the patient.
- the resilient bias of the retraction spring 102 is designed to be less than the force required for slidably advancing the piston 100 in the ampoule chamber 96, thereby ensuring that the medication is not prematurely ejected from the ampoule chamber.
- both embodiments of the invention are smooth and continuous with the initial advance of the ampoule chamber and hypodermic needle which eject with sufficient force for the needle to penetrate the skin of the patient. This initial movement is immediately followed by the continuous injection of the medication contained within the ampoule chamber. Since the device of this invention can not be readily reloaded it is safe for prescription as a disposable, single use medication. The device is very safe for use by patients and since it can only be used once, there is no possibility of passing a contagious or infectious diseases such as AIDS. The device can be provided with variable capacity and with needles of varied sizes and lengths suitable for pediatric use, or use by adults or obese persons.
- the device can be readily used by the patient, it is ideally suited for diabetic control, for anaphylatic shock, such as encountered with hypersensitive or allergic individuals, e.g., for dispensing of medication for bites by snakes, bees, insects, etc.
- anaphylatic shock such as encountered with hypersensitive or allergic individuals, e.g., for dispensing of medication for bites by snakes, bees, insects, etc.
- anaphylatic shock such as encountered with hypersensitive or allergic individuals, e.g., for dispensing of medication for bites by snakes, bees, insects, etc.
- anaphylatic shock such as encountered with hypersensitive or allergic individuals, e.g., for dispensing of medication for bites by snakes, bees, insects, etc.
- the device is entirely pre- loaded, little physical ability and judgement is required of the patient and the device can be used by children, handicapped persons or persons whose judgement or dexterity has been temporarily impaired by shock.
- the device can be used to inject only vertically as it has a large exterior surface that is applied to the skin which is relatively large compared to the depth of the needle. Accordingly the device cannot be used for intravenous injections which, of course, require skilled and licensed personnel.
- the device is provided with a transparent structure, e.g., formed of transparent plastics, thereby readily permitting observation of the contents of the ampoule.
- the actuator button can be suitably color-coated, e.g., preferably molded of a red colored plastic.
- the device also includes a protective cover 132 which is mounted about the side wall 134 of the housing 84 and which engages against an annular rim 136 that extends about the periphery of the housing, preferably at its mid-portion. This permits the cover to be reapplied over the opposite end of the housing after use, thereby encasing the needle in a protective chamber when the device is disposed.
- the extreme compactness of the device and its low profile stabilizes the device when used by the patient. Additionally, the low profile and compactness of the injection device greatly aids packaging and distribution by the pharmaceutical supply house. All of the component parts of the injection device can be fabricated of readily available materials such as plastics using injection molding techniques for mass production. The device can be marketed with significantly lower costs than conventional syringes. The device can be assembled and pre ⁇ loaded with measured amounts of medication under sterile conditions by the pharmaceutical supply house and can be sealed with the frangible sterile tape and the protective overlay tape, isolating the medication from contact with the external environment.
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Abstract
The invention is a pre-charged, disposable syringe capable of use by patients. The syringe has a housing (10) with a cover (40) having a central aperture (36) which receives an actuator button (33). The actuator button (33) extends to an internal piston which is mounted over a medication ampoule (24). The ampoule (24) has a dependent hypodermic needle (22) which is slidably received in the housing (10) and moves between recessed and projected positions. In its recessed position, the ampoule is totally contained within the housing, and in its projected position, the hypodermic needle (22) projects from the housing. The housing (10) contains an actuator spring (70), which is compressed and biased to move the piston and the ampoule into its projected position. The medication is discharged from the ampoule by the mechanically coupled piston, or by the release of air from an internal air pressure chamber (43). The actuator button (33) is covered with a protective, removable cap (38).
Description
PRELOADED AUTOMATIC DISPOSABLE SYRINGE BACKGROUND OF THE INVENTION
FIELD OF INVENTION
This invention relates to a hypodermic medicinal injector and, in particular, to a hypodermic syringe which is safe and capable of one time use by patients, handicapped, totally blind or aged persons and children.
BRIEF STATEMENT OF THE PRIOR ART
Various devices have been marketed for automated injection of medication. A currently marketed system under the trade name Medi-Jector Easy is promoted as a needle-free, insulin injection system. While this device avoids the use of injection needles, it is intended for use by medically trained personnel to maintain proper sterility, and it is not a disposable injection system that can be readily used by patients, or incapacitated persons.
Another device which has been recently introduced is marketed under the name Inject-Ease. This device uses a hypodermic needle and has interchangeable spacer rings to control the depth of needle penetration. None of the devices currently marketed provide a disposable needle type syringe for application of medication which is safe, sterile and is adaptable for use by patients, including children and handicapped and elderly patients. In many applications, there is no current substitute for
administration of medication by medically trained and skilled persons, since there is no syringe which heretofore has been available with accurately measured dosages of medication, and which can be used by the patient. Thus, diabetic patients, or patients suffering chronic allergies, must be dependent upon receiving medical attention and care for administration of medication.
A syringe for use by patients must be disposable, with a design which will prevent reloading, thereby avoiding misuse of the syringe and the possibility of cross infection with agents such as AIDS viruses. The hypodermic needle of the syringe should be totally protected from contamination, and the syringe should be capable of mass production, thereby insuring its low cost. It is a desirable objective, at this time, to supply the syringe with variable size needles from 1/8 to 1/4 inch and of 23 to 30 gauge, for pediatric, adults and obese patients. It is also an objective to provide a syringe which is preloaded by a licensed pharmaceutical company, insuring sterility and accuracy of dosage and strength of the medication.
BRIEF STATEMENT OF THE INVENTION
This invention comprises a pre-charged, disposable syringe capable of use by patients. The syringe includes a housing with a cover having a central aperture which receives an actuator button. The actuator button extends to an internal piston which is mounted over a medication ampoule. The
ampoule has a dependent hypodermic needle which is slidably received in the housing for movement between recessed and projected positions. In its recessed position, the ampoule is totally contained and supported within the housing, and in its projected position, the hypodermic needle projects out of the housing. The housing contains an actuator spring, which is compressed and biased to move the piston and the ampoule into its projected position. The medication is discharged from the ampoule by the mechanically coupled piston, or by the release of air from an internal air pressure chamber. The actuator button is locked for safety with a detent and plastic ring and is covered with a protective, removable cap to prevent accidental or unintended injection of the medication.
BRIEF DESCRIPTION OF THE DRAWINGS
The invention will be described with reference to the figures of which:
FIGURE 1 is an exploded perspective view of the air activated embodiment of the invention; FIGURE 2 is an elevational sectional view of the embodiment of FIGURE 1, fully loaded in a static, preactivated state;
FIGURE 3 is a partial, elevational sectional view of the embodiment of FIGURE 1 is its discharged state; FIGURE 4 is a perspective view of the assembled and loaded syringe of the invention;
FIGURE 5 illustrates removal of the protective tape from the underside of the syringe;
FIGURE 6 is a view of the syringe, uncovered, and in a position to inject its medication; FIGURE 7 is a view of the syringe after use, with the cover replaced on its undersurface for disposal;
FIGURE 8 is an elevational sectional view of a spring activated mechanism, in a static, preactivated state; and FIGURE 9 is an elevational sectional view of the device of FIGURE 8 is its discharged state.
DESCRIPTION OF PREFERRED EMBODIMENTS Referring now to FIGURE 1, the invention is illustrated in exploded view. The particular embodiment illustrated in FIGURE 1 is the air activated device. The device has a housing 10 which is preferably cylindrical of relatively low height or elevation, and has a central cavity 12 which receives the operating mechanism. The central cavity 12 has an internal well 14 with a right-angle, vertical cylindrical wall 16 which slidably receives a cylindrically shaped ampoule member 18. The ampoule member 18 has a hypodermic needle 22 that extends through its under surface and communicates with the medication chamber, described in greater detail with reference to FIGURE 2. An annular groove 26 is provided about the outer side wall 28 of the ampoule 18 which is engaged by a sealing plastic ring (shown in FIGURE 2) . The upper end of the sidewall of the ampoule 18 has an annular recess 32 which
serves as a chamber for housing a compression spring (also shown in FIGURE 2) . The actuator button 33 has a central upright boss 34 which is received in the central aperture 36 of the cover 40. The button 33 and has a circular base 44 which carries, on its undersurface, a knife 42 having a circular blade.
Referring now to FIGURE 2, the invention will be described in greater detail. As shown in FIGURE 2, the housing 10 has an outer annular chamber 43 which is the air supply chamber for the mechanism. A fill port 46 is provided in the upper wall of the air chamber and this port 46 communicates with an aligned aperture 48 in the cover. A pneumatic valve 50 is inserted in the aligned aperture 48 and fill port 46. This valve 50 is of a general grommet-shape with a through passage 52 that is normally sealed by the resilient deformation of the valve member under the internal pressure within the air chamber. The internal air chamber communicates with the interior, medication chamber 24 through a valve 54 which is sealed by a plastic ring 56. The valve has an annular seat 58 and is entirely covered by this plastic ring seal 56. The seal 56 is received in annular groove 26 about the ampoule member 18, and thus also serves as a detent to restrain the ampoule member 18 and needle 22 within the housing. Seated within the medication chamber 24 is the cylindrical cup-shaped ampoule member 18 which supports the hypodermic needle 22 on its under surface. The hypodermic needle 22 is aligned with a central through aperture 60 in the bottom wall 62 of the
housing 10 and is of sufficient length that when the ampoule member 18 is in its illustrated, retracted position, the hypodermic needle 22 is withdrawn from this aperture 60. The ampoule member 18 has sufficient travel within the housing 10 to project the needle 22 through the aperture 60 and a predetermined distance into the tissue of the patient.
The actuator button 33 has a central raised boss 34 that extends through the central aperture 36 of the cover 40. The button 33 is enclosed within a protective cover 38 which seats against an annular rim 39 about the mid-portion of the housing 10. The cover 38 can be sealed to the housing by a tear tape, if desired. The button 33 supports, on its undersurface, a knife 42 with a circular blade. The knife blade has a sharp circular cutting edge 66 which is aligned with the plastic ring 56 so that it will puncture this plastic ring and permit the discharge of the pressured air from the annular air chamber 43 past the valve and into the ampoule chamber. The knife also has a circular groove 67 which communicates with a passageway 69 that extends into communication with the internal chamber 24 of the ampoule member 18.
The ampoule member 18 has an annular well 32 in its upper edge which provides a chamber for the actuator spring 70. The actuator spring 70 is a compression coil spring biased between the undersurface of the button 33 and the bottom wall of the annular well 32. This spring has sufficient strength and resiliency to advance the ampoule member 18 instantaneously upon release of the detent, previously described, and extend
the hypodermic needle 22 through the frangible sterile tape 72 on the undersurface of the housing and into the patient's subcutaneous space. The extended positions of the ampoule member 18 and needle 22 are shown in FIGURE 3. This extension of the ampoule member 18 and hypodermic needle 22 occurs sufficiently rapidly to precede the application of air pressure through circular groove 67 in the knife 42 and the passageway 69 of the button. Thus the needle 22 is extended before air pressure is applied to the ampoule 74 contained within the ampoule chamber 24. The ampoule 74 is formed by an elastic balloon which is received within and sealed to the inner walls of the ampoule chamber, containing medication 78 within its sealed interior. The air pressure supplied by the air chamber 43 through the air valve 54 and into the ampoule chamber is sufficient to collapse the medication balloon and inject the medication 78 contained within the balloon into the patient.
The undersurface of the housing 10 has a frangible sterile tape 72 which is permanently bonded to the housing, and which overlies the through aperture 60, and an overlying, protective sterile tape 80. The protective overlay tape 80 is bonded to the housing and the sterile tape 72 with a pressure sensitive adhesive to permit its removal from the injection device immediately prior to use. FIGURE 4 illustrates the hypodermic syringe of the invention as it would be received by the patient. The syringe is preloaded with a precisely measured dosage of medication and
has the proper selection of needle size for the patient. All of this information can be coded on the syringe itself. The protective cover 38 overlies the actuator button 33, and must be removed by the patient for access to the button. As shown in FIGURE 5, the patient or user will first remove the protective overlay tape 80, exposing the underlying frangible, sterile tape. As shown in FIGURE 6, the patient will then position the syringe against a suitable skin surface. Preferably, the undersurface of the housing and the sterile tape 72 is coated with an antiseptic pressure sensitive adhesive so that, when placed on the skin of a patient, the undersurface of the device will disinfect and be slightly tacky and will stick to the skin of the patient. The patient then depresses the actuator button 33, breaking the detent of the plastic ring 56. This will release the spring 70 to advance the knife 42 through the plastic ring 56, and permit the ampoule member 18 to be ejected into its extended position. The air pressure which is also released from the annular air chamber 43 will fill the ampoule chamber 24, raising its internal pressure sufficiently to eject the medication from the ampoule 74. Once the injection is completed, the patient removes the device which is disposed as it cannot be readily reloaded for reuse. For this purpose, the protective cover 38, which was removed from over the actuator button, is replaced on the underside of the syringe, totally enclosing the needle 22, as shown in FIGURE 7.
Referring now to FIGURE 8, the alternative embodiment of the invention will be described. As there illustrated, this device 82 has a cylindrical, cup-shaped housing 84 having an outer wall 86 defined by a right-angle cylindrical wall, and a central lesser diameter well 88. The bottom wall 90 of the housing 84 has a central through aperture 92 which slidably receives the hypodermic needle 94. The ampoule member 96 is a cylindrical cup-shaped member which contains medication 98 and which also receives a slidable piston 100. The piston 100 engages the inside wall of the cylindrical member 96 in a sliding seal which prevents leaking of the medication from the ampoule member 96. The ampoule member 96 is resiliently biased into its retractable position by a helical coil spring 102 which is seated in the central well 88 of the housing and which is collapsed when the ampoule member 96 is driven into its extended position.
The actuator button 104 is slidably received in a central aperture 106 of the top cover 108. The actuator button 104 is restrained to this cover by a detent 112 formed by an annular groove 114 about its outer, upper wall in which is seated a resilient clip washer 116. The button 104 has a cylindrical skirt 118 and a single, outwardly flared flange 120. The cover 108 has a central inwardly and downwardly dependent skirt 122 which receives the cylindrical skirt 118 of the actuator button 104.
A cylindrical boss 124 is downwardly dependent from the undersurface of the button 104 and has a diameter to permit it
to be received within the ampoule member 96. The boss 124 is immediately above, and attached to, the piston 100 which is slidably contained within the ampoule member 96. An actuator spring 128 in the form of a compression coil spring is resiliently biased between the undersurface of the cover and the upper surface of the flange of the actuator button. When the device is in its armed and loaded condition as illustrated in FIGURE 8, the actuator spring 128 is compressed.
In use, the patient removes the protective overlay tape 130 from the undersurface of the device, in the manner previously described and illustrated in FIGURE 5. Preferably, the undersurface of the device has an antiseptic, pressure sensitive coating permitting its application to the skin of a patient. In this position, the device is ready for injection of the medication which is contained within the ampoule member 96. The patient presses on the actuator button 104 sufficiently to override the resilient detent of the circular clip washer 116. This permits the actuator spring 128 to be released, forcing the ampoule chamber 96 outwardly into its extended position, which is shown in FIGURE 9. In this position, the ampoule needle 94 projects through the skin of the patient. When the ampoule chamber 96 bottoms against the bottom wall 90 of the central well 88, the actuator spring 128 continues the travel of the actuator button, and advances the piston 100 through the ampoule chamber 96, ejecting the medication 98 in this chamber through the hypodermic needle 94, into the patient. The resilient bias of the retraction
spring 102 is designed to be less than the force required for slidably advancing the piston 100 in the ampoule chamber 96, thereby ensuring that the medication is not prematurely ejected from the ampoule chamber. Special Advantages of the Invention
The ejection operation of both embodiments of the invention is smooth and continuous with the initial advance of the ampoule chamber and hypodermic needle which eject with sufficient force for the needle to penetrate the skin of the patient. This initial movement is immediately followed by the continuous injection of the medication contained within the ampoule chamber. Since the device of this invention can not be readily reloaded it is safe for prescription as a disposable, single use medication. The device is very safe for use by patients and since it can only be used once, there is no possibility of passing a contagious or infectious diseases such as AIDS. The device can be provided with variable capacity and with needles of varied sizes and lengths suitable for pediatric use, or use by adults or obese persons.
Since the device can be readily used by the patient, it is ideally suited for diabetic control, for anaphylatic shock, such as encountered with hypersensitive or allergic individuals, e.g., for dispensing of medication for bites by snakes, bees, insects, etc. As the device is entirely pre- loaded, little physical ability and judgement is required of the patient and the device can be used by children,
handicapped persons or persons whose judgement or dexterity has been temporarily impaired by shock.
The device can be used to inject only vertically as it has a large exterior surface that is applied to the skin which is relatively large compared to the depth of the needle. Accordingly the device cannot be used for intravenous injections which, of course, require skilled and licensed personnel.
Preferably, the device is provided with a transparent structure, e.g., formed of transparent plastics, thereby readily permitting observation of the contents of the ampoule. The actuator button can be suitably color-coated, e.g., preferably molded of a red colored plastic. In its preferred embodiment, as shown in FIGURE 3, the device also includes a protective cover 132 which is mounted about the side wall 134 of the housing 84 and which engages against an annular rim 136 that extends about the periphery of the housing, preferably at its mid-portion. This permits the cover to be reapplied over the opposite end of the housing after use, thereby encasing the needle in a protective chamber when the device is disposed.
The extreme compactness of the device and its low profile stabilizes the device when used by the patient. Additionally, the low profile and compactness of the injection device greatly aids packaging and distribution by the pharmaceutical supply house.
All of the component parts of the injection device can be fabricated of readily available materials such as plastics using injection molding techniques for mass production. The device can be marketed with significantly lower costs than conventional syringes. The device can be assembled and pre¬ loaded with measured amounts of medication under sterile conditions by the pharmaceutical supply house and can be sealed with the frangible sterile tape and the protective overlay tape, isolating the medication from contact with the external environment.
The invention has been described with reference to the illustrated and presently preferred embodiment. It is not intended that the invention be unduly limited by this disclosure of the presently preferred embodiment. Instead, it is intended that the invention be defined, by the means, and their obvious equivalents, set forth in the following claims:
Claims
1. A syringe which comprises: a. housing having a first aperture in its bottom wall and a second aperture in its top wall; b. a cylinder received in said housing mounted in said housing for sliding movement between said apertures, a through bore in the bottom wall of said cylinder and a hypodermic needle permanently mounted therein, and a piston slidably received in said cylinder; c. a dispenser carriage mounted in said housing and moveable therein between retracted and extended positions; d. a trigger button carried on said carriage and projecting through said second aperture; e. means coupling said piston to said carriage; f. cylinder retraction means within said housing to maintain said needle withdrawn in said housing; g. an actuator spring received within said housing and bearing against said cylinder to extend said needle through said first aperture in the bottom wall of said housing; h. a detent engaging said carriage in its retracted position and restraining its movement in said housing; and i. a sterile seal cover extending across said first aperture.
2. The syringe of claim 1 wherein said detent includes an annular groove about said actuator button and a snap ring engaged in said annular groove and bearing against the top wall of said housing.
3. The syringe of claim 2 wherein said carriage includes an annular flange within said housing and wherein said actuator spring is biased between the inside top wall of said housing and said anular flange.
4. The syringe of claim 3 wherein said carriage bears, on its undersurface, a boss which is received within said cylinder and which abuts against said piston.
5. The syringe of claim 4 including a medication within said cylinder.
6. The syringe of claim 1 including a protective sheet material overlying said seal cover and bonded thereto by a peelable, pressure sensitive adhesive.
7. The syringe of claim 6 wherein said pressure sensitive adhesive includes an antiseptic agent.
8. The syringe of claim 6 wherein said pressure sensitive adhesive includes a tacifier agent, rendering the underside of said syringe tacky upon removal of said protective sheet material.
9. The syringe of claim 1 wherein said cylinder retraction means is a helical coil spring which is received between the bottom wall of said cylinder and the bottom wall of said housing.
10. The syringe of claim 1 including a cup-shaped cap received over an end of said housing.
11. The syringe of claim 10 wherein said housing has an annular rim about its mid-portion and said cap seats against said annular rim.
12. The syringe of claim 11 wherein the position of said cap on said housing can be reversed, end-to-end, of said housing.
13. The syringe of claim 1 wherein said housing includes an annular chamber and an internal passageway communicating between said annular chamber and said cylinder, above said piston.
14. The syringe of claim 1 wherein said annular chamber has an external port sealed with a check valve to permit air pressurization of said annular chamber and wherein said internal passageway includes frangible valve means.
15. The syringe of claim 14 wherein said internal passageway includes an annulus surrounding said cylinder, and said frangible valve means is an annular ring seated in said annulus.
16. The syringe of claim 15 wherein said cylinder has an annular groove about its outer wall and said annular ring is seated therein to also function as said detent to restrain movement of said cylinder in said housing.
17. The syringe of claim 16 including a knife carried on the underside of said actuator button immediately above said frangible annular ring.
18. The syringe of claim 17 including a protective sheet material overlying said seal cover and bonded thereto by a peelable, pressure sensitive adhesive.
19. The syringe of claim 17 wherein said pressure sensitive adhesive includes an antiseptic agent.
20. The syringe of claim 17 wherein said pressure sensitive adhesive includes a tacifier agent, rendering the underside of said syringe tacky upon removal of said protective sheet material.
21. The syringe of claim 1 wherein said cylinder retraction means is a helical coil spring which is received between the bottom wall of said cylinder and the bottom wall of said housing.
22. The syringe of claim 1 including a cup-shaped cap received over an end of said housing.
23. The syringe of claim wherein said housing has an annular rim about its mid-portion and said cap seats against said annular rim.
24. The syringe of claim 22 wherein the position of said cap on said housing can be reversed, end-to-end, of said housing.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE68920014T DE68920014T2 (en) | 1988-06-20 | 1989-06-20 | PRE-FILLED AUTOMATIC DISPOSAL SYRINGE. |
EP89907965A EP0379560B1 (en) | 1988-06-20 | 1989-06-20 | Preloaded automatic disposable syringe |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/208,486 US4894054A (en) | 1988-06-20 | 1988-06-20 | Preloaded automatic disposable syringe |
US208,486 | 1988-06-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1989012473A1 true WO1989012473A1 (en) | 1989-12-28 |
Family
ID=22774782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1989/002689 WO1989012473A1 (en) | 1988-06-20 | 1989-06-20 | Preloaded automatic disposable syringue |
Country Status (6)
Country | Link |
---|---|
US (2) | US4894054A (en) |
EP (1) | EP0379560B1 (en) |
JP (1) | JPH03501348A (en) |
AT (1) | ATE115416T1 (en) |
DE (1) | DE68920014T2 (en) |
WO (1) | WO1989012473A1 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5295965A (en) * | 1992-01-07 | 1994-03-22 | Survival Technology, Inc. | Automatic injectors |
WO1995013838A1 (en) * | 1993-11-18 | 1995-05-26 | Elan Medical Technologies Limited | Intradermal drug delivery device |
US5480381A (en) * | 1991-08-23 | 1996-01-02 | Weston Medical Limited | Needle-less injector |
US5658259A (en) * | 1995-10-19 | 1997-08-19 | Meridian Medical Technologies, Inc. | Dental cartridge assembly auto-injector with protective needle cover |
US5858001A (en) * | 1995-12-11 | 1999-01-12 | Elan Medical Technologies Limited | Cartridge-based drug delivery device |
US5997501A (en) * | 1993-11-18 | 1999-12-07 | Elan Corporation, Plc | Intradermal drug delivery device |
WO2012032411A2 (en) | 2010-09-07 | 2012-03-15 | Tecpharma Licensing Ag | Automatic injection device |
US9180244B2 (en) | 2010-04-21 | 2015-11-10 | Abbvie Biotechnology Ltd | Wearable automatic injection device for controlled delivery of therapeutic agents |
JP2016116948A (en) * | 2016-03-28 | 2016-06-30 | セイコーエプソン株式会社 | Liquid injection system |
WO2017182530A1 (en) * | 2016-04-19 | 2017-10-26 | Philip Douglas | Apparatus for administering liquid into skin |
US11298457B2 (en) | 2016-09-27 | 2022-04-12 | Sanofi-Aventis Deutschland Gmbh | Medicament delivery device |
US11452820B2 (en) | 2016-09-27 | 2022-09-27 | Sanofi-Aventis Deutschland Gmbh | Medicament delivery device |
Families Citing this family (169)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK134691D0 (en) * | 1991-07-12 | 1991-07-12 | Novo Nordisk As | APPARATUS |
US5167632A (en) * | 1992-01-24 | 1992-12-01 | New Potency Products, Inc. | Syringe |
US5569189A (en) * | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
US5894015A (en) * | 1993-04-07 | 1999-04-13 | Rechtin; Michael D. | Disinfection of medical sharps |
US5643222A (en) * | 1993-08-23 | 1997-07-01 | Mahurkar; Sakharam D. | Hypodermic needle assembly |
US5836921A (en) * | 1993-08-23 | 1998-11-17 | Mahurkar; Sakharam D. | Hypodermic needle assembly |
CA2132277C (en) * | 1993-10-22 | 2005-05-10 | Giorgio Cirelli | Injection device |
IE77523B1 (en) * | 1995-09-11 | 1997-12-17 | Elan Med Tech | Medicament delivery device |
GB9612724D0 (en) * | 1996-06-18 | 1996-08-21 | Owen Mumford Ltd | Improvements relating to injection devices |
US6146361A (en) * | 1996-09-26 | 2000-11-14 | Becton Dickinson And Company | Medication delivery pen having a 31 gauge needle |
US5957895A (en) * | 1998-02-20 | 1999-09-28 | Becton Dickinson And Company | Low-profile automatic injection device with self-emptying reservoir |
DE19900792C1 (en) | 1999-01-12 | 2000-06-15 | Disetronic Licensing Ag | Injection unit forming part of e.g. pen-type self-injection syringe has continuous dosing stop in spiral form with constant pitch ensuring close fine control and accuracy in use |
DE19900827C1 (en) | 1999-01-12 | 2000-08-17 | Disetronic Licensing Ag | Device for the dosed administration of an injectable product |
DE59911951D1 (en) * | 1999-12-03 | 2005-05-25 | Mattern Udo | Combination of a device for the injection of antiparasitic drugs in pets and an antiparasitic agent |
US7530964B2 (en) * | 2000-06-30 | 2009-05-12 | Elan Pharma International Limited | Needle device and method thereof |
WO2002081012A2 (en) | 2001-04-06 | 2002-10-17 | Disetronic Licensing Ag | Infusion set |
US7544188B2 (en) | 2001-07-19 | 2009-06-09 | Intelliject, Inc. | Medical injector |
US6830562B2 (en) * | 2001-09-27 | 2004-12-14 | Unomedical A/S | Injector device for placing a subcutaneous infusion set |
US6796967B2 (en) * | 2001-10-22 | 2004-09-28 | Nps Pharmaceuticals, Inc. | Injection needle assembly |
SI2221076T1 (en) * | 2001-11-09 | 2013-06-28 | Alza Corporation | Pneumatic powered autoinjector |
HU227056B1 (en) * | 2001-11-09 | 2010-06-28 | Alza Corp | Collapsible syringe cartridge related cases |
ITTO20011228A1 (en) * | 2001-12-28 | 2003-06-28 | Cane Srl | DISPOSABLE NEEDLE CONTAINER. |
US6979316B1 (en) | 2002-05-23 | 2005-12-27 | Seedlings Life Science Ventures Llc | Apparatus and method for rapid auto-injection of medication |
TWI314464B (en) * | 2002-06-24 | 2009-09-11 | Alza Corp | Reusable, spring driven autoinjector |
AU2003278798A1 (en) * | 2002-09-12 | 2004-04-30 | Children's Hospital Medical Center | Method and device for painless injection of medication |
US20040084162A1 (en) * | 2002-11-06 | 2004-05-06 | Shannon Thomas Gerard | Low slough tissue products and method for making same |
US6951598B2 (en) * | 2002-11-06 | 2005-10-04 | Kimberly-Clark Worldwide, Inc. | Hydrophobically modified cationic acrylate copolymer/polysiloxane blends and use in tissue |
US20040084164A1 (en) * | 2002-11-06 | 2004-05-06 | Shannon Thomas Gerard | Soft tissue products containing polysiloxane having a high z-directional gradient |
US7252651B2 (en) | 2003-01-07 | 2007-08-07 | Becton, Dickinson And Company | Disposable injection device |
CA2523267C (en) | 2003-04-23 | 2013-09-03 | Biovalve Technologies, Inc. | Hydraulically actuated pump for long duration medicament administration |
EP1475113A1 (en) * | 2003-05-08 | 2004-11-10 | Novo Nordisk A/S | External needle inserter |
ATE392223T1 (en) * | 2003-05-08 | 2008-05-15 | Novo Nordisk As | INTERNAL NEEDLE INTRODUCER |
JP4509100B2 (en) * | 2003-05-08 | 2010-07-21 | ノボ・ノルデイスク・エー/エス | Infusion device attachable to skin with removable needle insertion actuation |
US6926694B2 (en) * | 2003-05-09 | 2005-08-09 | Medsolve Technologies, Llc | Apparatus and method for delivery of therapeutic and/or diagnostic agents |
EP1502613A1 (en) * | 2003-08-01 | 2005-02-02 | Novo Nordisk A/S | Needle device with retraction means |
IL157981A (en) | 2003-09-17 | 2014-01-30 | Elcam Medical Agricultural Cooperative Ass Ltd | Auto-injector |
IL157984A (en) * | 2003-09-17 | 2015-02-26 | Dali Medical Devices Ltd | Autoneedle |
CN101415389A (en) * | 2003-10-02 | 2009-04-22 | 生物平衡公司 | Dried biotherapeutic composition, uses, and device and methods for administration thereof |
US20070009490A1 (en) * | 2003-10-02 | 2007-01-11 | Conte Anthony E | Dried biotherapeutic composition, uses, and device and methods for administration thereof |
KR20060099520A (en) * | 2003-10-21 | 2006-09-19 | 노보 노르디스크 에이/에스 | Medical skin mountable device |
WO2005079440A2 (en) * | 2004-02-17 | 2005-09-01 | Children's Hospital Medical Center | Improved injection devicew for administering a vaccine |
IL160891A0 (en) | 2004-03-16 | 2004-08-31 | Auto-mix needle | |
CA2560788A1 (en) | 2004-03-26 | 2005-10-06 | Unomedical A/S | Injector device for infusion set |
WO2005094920A1 (en) * | 2004-03-30 | 2005-10-13 | Novo Nordisk A/S | Actuator system comprising lever mechanism |
US9089636B2 (en) | 2004-07-02 | 2015-07-28 | Valeritas, Inc. | Methods and devices for delivering GLP-1 and uses thereof |
US8062250B2 (en) * | 2004-08-10 | 2011-11-22 | Unomedical A/S | Cannula device |
EP1804856A1 (en) * | 2004-09-22 | 2007-07-11 | Novo Nordisk A/S | Medical device with transcutaneous cannula device |
WO2006032692A1 (en) * | 2004-09-22 | 2006-03-30 | Novo Nordisk A/S | Medical device with cannula inserter |
WO2006052737A1 (en) * | 2004-11-04 | 2006-05-18 | Sid Technologies, Llc | Automatic injector |
US7648482B2 (en) * | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems, and methods for medicament delivery |
US10737028B2 (en) | 2004-11-22 | 2020-08-11 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
EP1814611A4 (en) | 2004-11-22 | 2010-06-02 | Intelliject Inc | Devices, systems, and methods for medicament delivery |
US7648483B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US7947017B2 (en) * | 2004-11-22 | 2011-05-24 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US11590286B2 (en) | 2004-11-22 | 2023-02-28 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
US20090048563A1 (en) * | 2004-12-06 | 2009-02-19 | Novo Nordisk A/S | Ventilated Skin Mountable Device |
WO2006077263A1 (en) | 2005-01-24 | 2006-07-27 | Novo Nordisk A/S | Transcutaneous device assembly |
US8361026B2 (en) | 2005-02-01 | 2013-01-29 | Intelliject, Inc. | Apparatus and methods for self-administration of vaccines and other medicaments |
US8206360B2 (en) | 2005-02-01 | 2012-06-26 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US7731686B2 (en) * | 2005-02-01 | 2010-06-08 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US9022980B2 (en) | 2005-02-01 | 2015-05-05 | Kaleo, Inc. | Medical injector simulation device |
CA2762072C (en) | 2005-02-01 | 2017-08-29 | Intelliject, Inc. | Devices, systems, and methods for medicament delivery |
US8231573B2 (en) | 2005-02-01 | 2012-07-31 | Intelliject, Inc. | Medicament delivery device having an electronic circuit system |
GB2422784A (en) * | 2005-02-07 | 2006-08-09 | Caretek Medical Ltd | Disposable assembly comprising a needle or stylet |
US7985199B2 (en) * | 2005-03-17 | 2011-07-26 | Unomedical A/S | Gateway system |
CN101175516B (en) * | 2005-05-13 | 2011-02-16 | 诺和诺德公司 | Medical device adapted to detect disengagement of a transcutaneous device |
DE102005022532A1 (en) * | 2005-05-17 | 2006-11-23 | Tecpharma Licensing Ag | Delivery device with forced priming |
CA2550114C (en) | 2005-06-20 | 2013-11-19 | Sherwood Services, Ag | Safety shield for medical needles |
AU2006264122B2 (en) * | 2005-06-28 | 2010-12-02 | Unomedical A/S | Packing for infusion set and method of applying an infusion set |
US8998881B2 (en) | 2005-08-10 | 2015-04-07 | Alza Corporation | Method for delivering drugs to tissue under microjet propulsion |
ATE480278T1 (en) * | 2005-09-12 | 2010-09-15 | Unomedical As | INTRODUCTION SYSTEM FOR AN INFUSION SET WITH A FIRST AND SECOND SPRING UNIT |
GB2433032A (en) † | 2005-12-08 | 2007-06-13 | Owen Mumford Ltd | Syringe with dose adjustment means |
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US20090218243A1 (en) * | 2006-02-13 | 2009-09-03 | Unomedical A/S | Packing for Injection Device |
KR20080104342A (en) * | 2006-02-28 | 2008-12-02 | 우노메디컬 에이/에스 | Inserter for infusion part and infusion part provided with needle protector |
WO2007104756A1 (en) * | 2006-03-13 | 2007-09-20 | Novo Nordisk A/S | Medical system comprising dual purpose communication means |
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EP1917990A1 (en) | 2006-10-31 | 2008-05-07 | Unomedical A/S | Infusion set |
EP2125075A2 (en) | 2007-01-22 | 2009-12-02 | Intelliject, Inc. | Medical injector with compliance tracking and monitoring |
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FR2912919B1 (en) * | 2007-02-22 | 2009-05-01 | Bernard Perriere | MINIATURIZED INJECTION DEVICE FOR MEDICAL USE |
EP2114492A1 (en) * | 2007-03-06 | 2009-11-11 | Novo Nordisk A/S | Pump assembly comprising actuator system |
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WO2008131440A1 (en) * | 2007-04-23 | 2008-10-30 | Sid Technologies, Llc | Methods and devices for intradermal injection |
CN101715353B (en) * | 2007-05-07 | 2013-03-20 | 优诺医疗有限公司 | Cannula and delivery device |
DK2150195T3 (en) * | 2007-06-06 | 2010-12-06 | Unomedical As | Gas sterilized packaging |
DE202008017390U1 (en) | 2007-06-20 | 2009-08-13 | Unomedical A/S | Catheter and device for making such a catheter |
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RU2010103450A (en) | 2007-07-03 | 2011-08-10 | Уномедикал А/С (Dk) | INTRODUCTION DEVICE WITH BISTABLE EQUILIBRIUM STATES |
CN101790394B (en) | 2007-07-10 | 2012-10-17 | 优诺医疗有限公司 | Inserter having two springs |
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WO2009056616A1 (en) * | 2007-10-31 | 2009-05-07 | Novo Nordisk A/S | Non-porous material as sterilization barrier |
CA2714045A1 (en) * | 2008-02-08 | 2009-08-13 | Unomedical A/S | Assembly comprising inserter, cannula part and base part |
US20090204077A1 (en) * | 2008-02-13 | 2009-08-13 | Hasted Soren B | Moulded Connection Between Cannula and Delivery Part |
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US8021344B2 (en) * | 2008-07-28 | 2011-09-20 | Intelliject, Inc. | Medicament delivery device configured to produce an audible output |
USD994111S1 (en) | 2008-05-12 | 2023-08-01 | Kaleo, Inc. | Medicament delivery device cover |
CN102089021A (en) * | 2008-07-07 | 2011-06-08 | 优诺医疗有限公司 | Inserter for transcutaneous device |
US20110226652A1 (en) * | 2008-09-29 | 2011-09-22 | Richard Morgan Hickmott | Packing for Inserter |
GB0821492D0 (en) * | 2008-11-25 | 2008-12-31 | Team Holdings Uk Ltd | Integrated auto-injector cartridge system |
US20110224609A1 (en) * | 2008-12-08 | 2011-09-15 | Sid Technologies, Llc | Alignment of a Needle in an Intradermal Injection Device |
BRPI0923489A2 (en) | 2008-12-22 | 2016-01-26 | Unomedical As | medical device comprising adhesive pad |
US20100318218A1 (en) * | 2009-06-15 | 2010-12-16 | Muncy Jr Robert B | Pill Dispenser and Method |
JP2013500074A (en) | 2009-07-23 | 2013-01-07 | エスアイディー・テクノロジーズ・エルエルシー | Intradermal injection adapter |
CA2766475A1 (en) | 2009-07-30 | 2011-02-03 | Unomedical A/S | Inserter device with horizontal moving part |
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WO2011034516A1 (en) * | 2009-09-15 | 2011-03-24 | Becton, Dickinson And Company | Self-injection device |
KR101868765B1 (en) * | 2009-10-13 | 2018-06-18 | 발레리타스 인코포레이티드 | Fluid delivery device |
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WO2011112916A1 (en) | 2010-03-12 | 2011-09-15 | Sid Technologies, Llc | Assembly for use with a syringe |
CN102844060A (en) | 2010-03-30 | 2012-12-26 | 犹诺医药有限公司 | Medical device |
CA2798145C (en) | 2010-05-04 | 2022-10-18 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
EP2433663A1 (en) | 2010-09-27 | 2012-03-28 | Unomedical A/S | Insertion system |
EP2436412A1 (en) | 2010-10-04 | 2012-04-04 | Unomedical A/S | A sprinkler cannula |
US8814831B2 (en) * | 2010-11-30 | 2014-08-26 | Becton, Dickinson And Company | Ballistic microneedle infusion device |
IT1403293B1 (en) | 2010-12-27 | 2013-10-17 | Fond Don Carlo Gnocchi Onlus | NEEDLE APPLIANCE FOR TRANSDERMIC DRUG ADMINISTRATION. |
EP2489379B1 (en) | 2011-01-21 | 2020-09-23 | SID Technologies, LLC | Intradermal pen adapter |
WO2012101629A1 (en) | 2011-01-24 | 2012-08-02 | Elcam Medical Agricultural Cooperative Association Ltd. | Injector |
US8939943B2 (en) | 2011-01-26 | 2015-01-27 | Kaleo, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
US8627816B2 (en) | 2011-02-28 | 2014-01-14 | Intelliject, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
US9173999B2 (en) | 2011-01-26 | 2015-11-03 | Kaleo, Inc. | Devices and methods for delivering medicaments from a multi-chamber container |
CN102188762A (en) * | 2011-03-14 | 2011-09-21 | 张亚根 | Disposable safe injection pump |
US20130281932A1 (en) * | 2011-03-30 | 2013-10-24 | Ziv Harish | Palm-based injector actuation and safety surfaces |
EP2704768B1 (en) * | 2011-05-06 | 2018-10-10 | Sanofi-Aventis Deutschland GmbH | Reuse protection for disposable parts |
CA3037365C (en) | 2011-05-18 | 2021-04-13 | Becton, Dickinson And Company | Injection device |
US11197689B2 (en) | 2011-10-05 | 2021-12-14 | Unomedical A/S | Inserter for simultaneous insertion of multiple transcutaneous parts |
EP2583715A1 (en) | 2011-10-19 | 2013-04-24 | Unomedical A/S | Infusion tube system and method for manufacture |
US9440051B2 (en) | 2011-10-27 | 2016-09-13 | Unomedical A/S | Inserter for a multiplicity of subcutaneous parts |
EP2650031A1 (en) * | 2012-04-11 | 2013-10-16 | PharmaSens AG | Manual pressure activated application mechanism |
US9522235B2 (en) | 2012-05-22 | 2016-12-20 | Kaleo, Inc. | Devices and methods for delivering medicaments from a multi-chamber container |
GB201210082D0 (en) * | 2012-06-07 | 2012-07-25 | Consort Medical Plc | Improved syringe |
US20150209519A1 (en) * | 2012-08-14 | 2015-07-30 | Injector Aps | Disposable injector for injecting a liquid into a patient |
AU2013337308B2 (en) | 2012-11-05 | 2018-06-21 | Tdeltas | Ketone bodies to protect tissues from damage by ionizing radiation |
US11052231B2 (en) | 2012-12-21 | 2021-07-06 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
GB2523512A (en) | 2012-12-27 | 2015-08-26 | Kaleo Inc | Devices, systems and methods for locating and interacting with medicament delivery systems |
BR112015022253B1 (en) | 2013-03-12 | 2022-03-15 | Corium, Inc | microprojection applicator |
US20140288528A1 (en) * | 2013-03-15 | 2014-09-25 | Dr. Py Institute, Llc | Single-use needle assembly and method |
KR102341601B1 (en) | 2013-03-15 | 2021-12-21 | 코리움, 인크. | Microarray for delivery of therapeutic agent and methods of use |
JP2016514133A (en) | 2013-03-15 | 2016-05-19 | コリウム インターナショナル, インコーポレイテッド | MICROARRAY CONTAINING FINE STRUCTURE CONTAINING NO POLYMER, MANUFACTURING METHOD AND USE METHOD |
CA2903459C (en) | 2013-03-15 | 2024-02-20 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
US9474865B2 (en) | 2013-04-25 | 2016-10-25 | West Pharmaceutical Services, Inc. | Needle shield for disposable syringe with annular ring |
WO2015048799A1 (en) * | 2013-09-30 | 2015-04-02 | Medimop Medical Projects Ltd. | Needle retraction mechanism for autoinjector |
WO2015057408A1 (en) * | 2013-10-03 | 2015-04-23 | Jeff Baker | Medicament delivery and training cartridge system and mechanisms of actuation |
CA2942749C (en) * | 2014-04-24 | 2022-10-18 | Becton, Dickinson And Company | Catheter insertion mechanism for a patch pump |
CN206492062U (en) * | 2014-04-24 | 2017-09-15 | 贝克顿·迪金森公司 | Catheter insertion apparatus |
US9517307B2 (en) | 2014-07-18 | 2016-12-13 | Kaleo, Inc. | Devices and methods for delivering opioid antagonists including formulations for naloxone |
WO2016036866A1 (en) | 2014-09-04 | 2016-03-10 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
JP6035365B2 (en) * | 2015-03-02 | 2016-11-30 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | Self injection device |
WO2016154427A2 (en) | 2015-03-24 | 2016-09-29 | Kaleo, Inc. | Devices and methods for delivering a lyophilized medicament |
WO2017004067A1 (en) | 2015-06-29 | 2017-01-05 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
JP6830067B2 (en) | 2015-06-30 | 2021-02-17 | カレオ,インコーポレイテッド | Automatic syringe that administers medication in a prefilled syringe |
JOP20170042B1 (en) * | 2016-02-12 | 2022-09-15 | Amgen Inc | Drug Delivery Device, Method of Manufacture and Method of Use |
JP7014797B2 (en) | 2016-12-23 | 2022-02-01 | カレオ,インコーポレイテッド | Drug delivery devices and methods for delivering drugs to babies and children |
CA3046354A1 (en) | 2017-01-17 | 2018-07-26 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and event detection |
JP6921997B2 (en) | 2017-05-30 | 2021-08-18 | ウェスト ファーマ サービシーズ イスラエル リミテッド | Modular drive train for wearable syringes |
WO2020018433A1 (en) | 2018-07-16 | 2020-01-23 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and compliance detection |
EP4009936A4 (en) | 2019-08-09 | 2023-08-09 | Kaleo, Inc. | Devices and methods for delivery of substances within a prefilled syringe |
US20220111155A1 (en) * | 2020-10-09 | 2022-04-14 | Intact Pur-Needle Llc | Device for preventing needle reuse and injury, syringe, and method |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2605765A (en) * | 1947-06-05 | 1952-08-05 | Kollsman Paul | Automatic syringe |
US2752918A (en) * | 1949-08-17 | 1956-07-03 | Auguste Rooseboom | Hypodermic injection apparatus |
US2856924A (en) * | 1954-11-09 | 1958-10-21 | Daugherty And Rockwell | Automatic hypodermic syringe |
CA742024A (en) * | 1963-06-04 | 1966-09-06 | F. Baumgartner Willy | Injector device |
US3572336A (en) * | 1968-04-30 | 1971-03-23 | Daniel R Hershberg | Syringe |
DE2461272A1 (en) * | 1974-12-23 | 1976-07-01 | Baumgartner | Medical injection device - having liq. chamber, piston, injection needle, sleeve surrounding chamber, and spring locking chamber-sleeve |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2017924A (en) * | 1933-10-19 | 1935-10-22 | Joseph C Smith | Automatic applicator |
US2701566A (en) * | 1950-02-07 | 1955-02-08 | Becton Dickinson Co | Injection apparatus |
US2693186A (en) * | 1953-05-18 | 1954-11-02 | William M Riker | Disposable hypodermic injection syringe |
NL106573C (en) * | 1957-05-31 | |||
US3605743A (en) * | 1968-10-14 | 1971-09-20 | Raul Olvera Arce | Hypodermic syringe |
DE1957833A1 (en) * | 1968-11-21 | 1970-07-02 | Maurice Steiner | Injection syringe, especially injection syringe handled by the patient himself |
US3587575A (en) * | 1969-09-15 | 1971-06-28 | Lichtenstein Eric Stefan | Self-contained, moving needle syringe with hydraulic safety lock |
US3712301A (en) * | 1971-01-11 | 1973-01-23 | Survival Technology | Gun type hypodermic injector with rapid cartridge displacement within holder |
BE795162A (en) * | 1972-02-10 | 1973-08-08 | Philips Nv | INJEKTIE-INRICHTING |
US4267836A (en) * | 1976-11-12 | 1981-05-19 | Whitney Douglass G | Injection device and method |
SU787035A1 (en) * | 1978-01-11 | 1980-12-15 | Всесоюзный научно-исследовательский и испытательный институт медицинской техники | Device for injection of medical preparations |
US4227528A (en) * | 1978-12-26 | 1980-10-14 | Wardlaw Stephen C | Automatic disposable hypodermic syringe |
FR2539302B1 (en) * | 1983-01-17 | 1986-03-14 | Brunet Jean Louis | SYRINGE FOR MEDICAL USE |
NZ212899A (en) * | 1984-07-31 | 1987-10-30 | Phillips Pty Ltd N J | Piston operated adjustable volume dose injector for animals |
FR2599976A1 (en) * | 1986-06-16 | 1987-12-18 | Michel Pistor | Therapeutic, portable, completely self-contained, transdermic device provided with at least one member forming a needle or tip which gets through the cutaneous barrier |
CA1283827C (en) * | 1986-12-18 | 1991-05-07 | Giorgio Cirelli | Appliance for injection of liquid formulations |
-
1988
- 1988-06-20 US US07/208,486 patent/US4894054A/en not_active Expired - Fee Related
-
1989
- 1989-06-20 WO PCT/US1989/002689 patent/WO1989012473A1/en active IP Right Grant
- 1989-06-20 DE DE68920014T patent/DE68920014T2/en not_active Expired - Fee Related
- 1989-06-20 EP EP89907965A patent/EP0379560B1/en not_active Expired - Lifetime
- 1989-06-20 AT AT89907965T patent/ATE115416T1/en not_active IP Right Cessation
- 1989-06-20 JP JP1507383A patent/JPH03501348A/en active Pending
- 1989-12-07 US US07/447,517 patent/US5527287A/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2605765A (en) * | 1947-06-05 | 1952-08-05 | Kollsman Paul | Automatic syringe |
US2752918A (en) * | 1949-08-17 | 1956-07-03 | Auguste Rooseboom | Hypodermic injection apparatus |
US2856924A (en) * | 1954-11-09 | 1958-10-21 | Daugherty And Rockwell | Automatic hypodermic syringe |
CA742024A (en) * | 1963-06-04 | 1966-09-06 | F. Baumgartner Willy | Injector device |
US3572336A (en) * | 1968-04-30 | 1971-03-23 | Daniel R Hershberg | Syringe |
DE2461272A1 (en) * | 1974-12-23 | 1976-07-01 | Baumgartner | Medical injection device - having liq. chamber, piston, injection needle, sleeve surrounding chamber, and spring locking chamber-sleeve |
Non-Patent Citations (1)
Title |
---|
See also references of EP0379560A4 * |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5480381A (en) * | 1991-08-23 | 1996-01-02 | Weston Medical Limited | Needle-less injector |
US5295965A (en) * | 1992-01-07 | 1994-03-22 | Survival Technology, Inc. | Automatic injectors |
US5997501A (en) * | 1993-11-18 | 1999-12-07 | Elan Corporation, Plc | Intradermal drug delivery device |
WO1995013838A1 (en) * | 1993-11-18 | 1995-05-26 | Elan Medical Technologies Limited | Intradermal drug delivery device |
AU693136B2 (en) * | 1993-11-18 | 1998-06-25 | Elan Corporation, Plc | Intradermal drug delivery device |
US5658259A (en) * | 1995-10-19 | 1997-08-19 | Meridian Medical Technologies, Inc. | Dental cartridge assembly auto-injector with protective needle cover |
US5858001A (en) * | 1995-12-11 | 1999-01-12 | Elan Medical Technologies Limited | Cartridge-based drug delivery device |
US9180244B2 (en) | 2010-04-21 | 2015-11-10 | Abbvie Biotechnology Ltd | Wearable automatic injection device for controlled delivery of therapeutic agents |
US9821117B2 (en) | 2010-04-21 | 2017-11-21 | Abbvie Biotechnology Ltd | Wearable automatic injection device for controlled delivery of therapeutic agents |
WO2012032411A2 (en) | 2010-09-07 | 2012-03-15 | Tecpharma Licensing Ag | Automatic injection device |
WO2012032411A3 (en) * | 2010-09-07 | 2012-07-26 | Tecpharma Licensing Ag | Skin-patch automatic injection device |
JP2016116948A (en) * | 2016-03-28 | 2016-06-30 | セイコーエプソン株式会社 | Liquid injection system |
WO2017182530A1 (en) * | 2016-04-19 | 2017-10-26 | Philip Douglas | Apparatus for administering liquid into skin |
US11298457B2 (en) | 2016-09-27 | 2022-04-12 | Sanofi-Aventis Deutschland Gmbh | Medicament delivery device |
US11452820B2 (en) | 2016-09-27 | 2022-09-27 | Sanofi-Aventis Deutschland Gmbh | Medicament delivery device |
Also Published As
Publication number | Publication date |
---|---|
ATE115416T1 (en) | 1994-12-15 |
DE68920014D1 (en) | 1995-01-26 |
US4894054A (en) | 1990-01-16 |
EP0379560A1 (en) | 1990-08-01 |
DE68920014T2 (en) | 1995-07-27 |
EP0379560A4 (en) | 1991-04-10 |
JPH03501348A (en) | 1991-03-28 |
EP0379560B1 (en) | 1994-12-14 |
US5527287A (en) | 1996-06-18 |
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