WO1988010146A1 - Filter element for liquid chromatography - Google Patents
Filter element for liquid chromatography Download PDFInfo
- Publication number
- WO1988010146A1 WO1988010146A1 PCT/AU1988/000211 AU8800211W WO8810146A1 WO 1988010146 A1 WO1988010146 A1 WO 1988010146A1 AU 8800211 W AU8800211 W AU 8800211W WO 8810146 A1 WO8810146 A1 WO 8810146A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- filter element
- outer layers
- inner layer
- microns
- filter
- Prior art date
Links
- 238000004811 liquid chromatography Methods 0.000 title description 3
- 239000011148 porous material Substances 0.000 claims abstract description 8
- 239000002657 fibrous material Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 239000000919 ceramic Substances 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 238000004587 chromatography analysis Methods 0.000 claims 2
- 239000004698 Polyethylene Substances 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 229910010293 ceramic material Inorganic materials 0.000 claims 1
- 239000011236 particulate material Substances 0.000 claims 1
- -1 polyethylene Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920000098 polyolefin Polymers 0.000 claims 1
- 229920001169 thermoplastic Polymers 0.000 claims 1
- 239000000356 contaminant Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000002411 adverse Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/12—Composite membranes; Ultra-thin membranes
- B01D69/1213—Laminated layers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D39/00—Filtering material for liquid or gaseous fluids
- B01D39/14—Other self-supporting filtering material ; Other filtering material
Definitions
- the performance of an analytical column in a liquid chromatography system can be adversely effected by contaminants in the sample or the mobile phase or both.
- HPLC High Performance Liquid Chromatograph
- SUBSTITUTE SHEET One of the objects of the invention is to overcome sample degradation in the HPLC system by revealing a filter, (commonly referred to as a frit) which is made from composite non-metallic materials and specifically inert.
- the filter or frit can consist of relatively thin layers of inert porous materials detailed as A, B and C.
- a and C for example, can be a High Density Polymer having a thickness which typically can be made to vary between 0.1 to 3 millimetres depending on sample type, chromatographic conditions, and the like.
- the other or middle layer, or membrane, B can be, for example, a fibrous material made from glass, ceramic, cellulose carbon, or a similar inert material. This middle layer having a thickness which can vary, depending on application, between 0.05 to 1 millimetre.
- the outer layers A & C of the filter provide mechanical strength for the middle or membrane layer which is an object of the invention. Furthermore, the outer layers are designed to have greater porosity than the inner layer and in practice a multiple porosity filter and varying density is less susceptible to blockage than a filter of uniform porosity and density. This is also revealed as an object of the invention. Also revealed is that particulate packing material from the bore of the column becomes embedded into the outer layer of the filter which also serves as an integral part of the filter.
- Another object of the invention is to reveal that the composite materials used in the manufacture of the filter, enables the filter to be much thinner than conventional filters. This advantageously ensures the mobile phase will pass through the filter with minimal restriction.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Filtering Materials (AREA)
Abstract
A filter element comprising two outer layers of inert porous material and interposed between said outer layers one inner layer of inert porous material.
Description
FILTER ELEMENT FOR LIQUID CHROMATOGRAPHY
The performance of an analytical column in a liquid chromatography system, and in particular a High Performance Liquid Chromatograph (HPLC), can be adversely effected by contaminants in the sample or the mobile phase or both.
To protect the column from contaminants, and because the column is subjected to high pressure liquid flows (typically 500 to 20,000 psi) inherent in the HPLC technique, it has been found, in practice, that a porous metal filter is necessary to trap the contaminants.
However, many samples to be analysed by the HPLC column technique will react with porous metal filters causing sample degradation and therefore loss of sample integrity.
SUBSTITUTE SHEET
One of the objects of the invention is to overcome sample degradation in the HPLC system by revealing a filter, (commonly referred to as a frit) which is made from composite non-metallic materials and specifically inert.
The filter or frit can consist of relatively thin layers of inert porous materials detailed as A, B and C. A and C, for example, can be a High Density Polymer having a thickness which typically can be made to vary between 0.1 to 3 millimetres depending on sample type, chromatographic conditions, and the like. The other or middle layer, or membrane, B, can be, for example, a fibrous material made from glass, ceramic, cellulose carbon, or a similar inert material. This middle layer having a thickness which can vary, depending on application, between 0.05 to 1 millimetre.
The outer layers A & C of the filter provide mechanical strength for the middle or membrane layer which is an object of the invention. Furthermore, the outer layers are designed to have greater porosity than the inner layer and in practice a multiple porosity filter and varying density is less susceptible to blockage than a filter of uniform porosity and density. This is also revealed as an object of the invention. Also revealed is that particulate packing material from the bore of the column becomes embedded into the outer layer of the filter which also serves as an integral part of the filter.
Another object of the invention is to reveal that the composite materials used in the manufacture of the filter, enables the filter to be much thinner than conventional filters. This advantageously ensures the mobile phase will pass through the filter with minimal restriction.
SUBSTITUTE SHEET
Claims
1. . A filter element comprising two outer layers of inert porous material and interposed between said outer layers on inner layer of inert porous material.
2. A filter element as claimed in claim 1, wherein said outer layers are formed of a high density polymeric material.
3. A filter element as claimed in claim 1, wherein said outer layers have a thickness of from 0.1 to 3 millimetres.
4. A filter element as claimed in claim 1, wherein said outer layers are formed from a polyolefin such as polyethylene, polyfluorocarbon, a pol amide or other thermoplastic polymer.
5. A filter element as claimed in claim 1, wherein the inner layer has a thickness of 0.05 to 1 millimetre.
6. A filter element as claimed in claim 1, wherein the inner layer is formed of a silicious or ceramic material.
7. A filter element as claimed in claim 1, wherein the inner layer is formed of fibrous material.
8. A filter element as claimed in claim 7, wherein the fibrous material is selected from glass, ceramic, cellulose, carbon or other inert fibrous material.
SUBSTITUTE SHEET
9. A filter element as claimed in claim 1, wherein the porosity of the outer layers is greater than the porocity of the inner layers.
10. A filter element as claimed in claim 1, wherein the outer layers have a porosity such that particulate material of a chromatography column may lodge in the pores without blocking them.
11. A filter element as claimed in claim 1, wherein the outer layers have a pore size of 1 to 100 microns preferably about 35 microns.
12. A filter element as claimed in claim 9, wherein the inner layer has a pore size of 0.1 to 10 microns preferably 0.1 microns to 0.5 microns.
13. A chromatography system including a filter element in accordance with any preceding claim.
SUBSTITUTESHEET
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU270487 | 1987-06-25 | ||
| AUPI2704 | 1987-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1988010146A1 true WO1988010146A1 (en) | 1988-12-29 |
Family
ID=3693196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/AU1988/000211 WO1988010146A1 (en) | 1987-06-25 | 1988-06-24 | Filter element for liquid chromatography |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO1988010146A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1327472A1 (en) * | 2002-01-10 | 2003-07-16 | Filterwerk Mann + Hummel Gmbh | Filter element for removing oil from a gas stream |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2517753A (en) * | 1945-11-15 | 1950-08-08 | Johns Manville | Microporous sheet and method of manufacture |
| AU4147772A (en) * | 1971-04-22 | 1973-10-25 | Millipore Corp | Filter laminate construction |
| AU4356279A (en) * | 1978-01-23 | 1979-05-31 | Process Scientific Innovations Ltd. | Filter elements for gas or liquid |
| DE2940712A1 (en) * | 1979-10-08 | 1981-04-16 | Herbert 8961 Durach Pfennig | Filter material for vacuum cleaner bag - in which fine particles are retained by fabric with specified thickness polymer coating |
| AU7861581A (en) * | 1980-12-19 | 1982-06-24 | E.I. Du Pont De Nemours And Company | Felt composite |
| AU6800381A (en) * | 1978-02-22 | 1982-09-09 | Lucas, R.E. | Mist eliminator pack |
| JPS58180653A (en) * | 1982-04-19 | 1983-10-22 | 東レ株式会社 | Laminated nonwoven sheet for microfilter |
| JPS59206008A (en) * | 1983-05-10 | 1984-11-21 | Tdk Corp | Novel filter medium and its manufacture |
| JPS6058221A (en) * | 1983-09-09 | 1985-04-04 | Toyo Roshi Kk | Filter material for filtering air |
| FR2575398A1 (en) * | 1984-12-29 | 1986-07-04 | Ngk Insulators Ltd | FILTER CONSISTING OF A SUBSTRATE OF POROUS CERAMIC MATERIAL AND A MICROPOROUS MEMBRANE OF POLYMER RESINOUS MATERIAL AND PROCESS FOR PREPARING THE SAME |
| AU5747386A (en) * | 1985-05-23 | 1986-11-27 | Dow Chemical Company, The | A porous filter media and membrane support means |
-
1988
- 1988-06-24 WO PCT/AU1988/000211 patent/WO1988010146A1/en unknown
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2517753A (en) * | 1945-11-15 | 1950-08-08 | Johns Manville | Microporous sheet and method of manufacture |
| AU4147772A (en) * | 1971-04-22 | 1973-10-25 | Millipore Corp | Filter laminate construction |
| AU4356279A (en) * | 1978-01-23 | 1979-05-31 | Process Scientific Innovations Ltd. | Filter elements for gas or liquid |
| AU6800381A (en) * | 1978-02-22 | 1982-09-09 | Lucas, R.E. | Mist eliminator pack |
| DE2940712A1 (en) * | 1979-10-08 | 1981-04-16 | Herbert 8961 Durach Pfennig | Filter material for vacuum cleaner bag - in which fine particles are retained by fabric with specified thickness polymer coating |
| AU7861581A (en) * | 1980-12-19 | 1982-06-24 | E.I. Du Pont De Nemours And Company | Felt composite |
| JPS58180653A (en) * | 1982-04-19 | 1983-10-22 | 東レ株式会社 | Laminated nonwoven sheet for microfilter |
| JPS59206008A (en) * | 1983-05-10 | 1984-11-21 | Tdk Corp | Novel filter medium and its manufacture |
| JPS6058221A (en) * | 1983-09-09 | 1985-04-04 | Toyo Roshi Kk | Filter material for filtering air |
| FR2575398A1 (en) * | 1984-12-29 | 1986-07-04 | Ngk Insulators Ltd | FILTER CONSISTING OF A SUBSTRATE OF POROUS CERAMIC MATERIAL AND A MICROPOROUS MEMBRANE OF POLYMER RESINOUS MATERIAL AND PROCESS FOR PREPARING THE SAME |
| AU5747386A (en) * | 1985-05-23 | 1986-11-27 | Dow Chemical Company, The | A porous filter media and membrane support means |
Non-Patent Citations (3)
| Title |
|---|
| DERWENT ABSTRACT ACCESSION NO. 83-830085/48, Class F04; & JP,A,58 180 653 (TORAY IND. INC.), 22 October 1983 (22.10.83). * |
| PATENT ABSTRACTS OF JAPAN, C-273, page 36; & JP,A,59 206 008 (TDK K.K.), 21 November 1984 (21.11.84). * |
| PATENT ABSTRACTS OF JAPAN, C-295, page 103; & JP,A,60 058 221 (TOUYOU ROSHI K.K.), 4 April 1985 (04.04.85). * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1327472A1 (en) * | 2002-01-10 | 2003-07-16 | Filterwerk Mann + Hummel Gmbh | Filter element for removing oil from a gas stream |
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