WO1988004666A3 - Lung cytotoxic peptides - Google Patents

Lung cytotoxic peptides Download PDF

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Publication number
WO1988004666A3
WO1988004666A3 PCT/US1987/003399 US8703399W WO8804666A3 WO 1988004666 A3 WO1988004666 A3 WO 1988004666A3 US 8703399 W US8703399 W US 8703399W WO 8804666 A3 WO8804666 A3 WO 8804666A3
Authority
WO
WIPO (PCT)
Prior art keywords
cys
arg
ala
ile
gly
Prior art date
Application number
PCT/US1987/003399
Other languages
French (fr)
Other versions
WO1988004666A2 (en
Inventor
Samuel Solomon
Original Assignee
Ivax Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Lab Inc filed Critical Ivax Lab Inc
Publication of WO1988004666A2 publication Critical patent/WO1988004666A2/en
Publication of WO1988004666A3 publication Critical patent/WO1988004666A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A method of reducing lung tumor population in a cancer inflicted patient which comprises contacting lung carcinoma cells in said patient with a peptide selected from the group consisting of Cys-Try-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Try-Gly-Thr-Cys-Ile-Try-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys or Ala-Cys-Try-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Try-Gly-Thr-Cys-Ile-Try-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys. Anticarcinoma compositions are disclosed including an isotonic solution and an aerosol spray, each containing an effective amount of said peptide. Also disclosed is method of producing substantially pure peptide mixture of each of said peptides. Compositions including the compound Cys-Try-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Try-Gly-Thr-Cys-Ile-Try-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys are provided.
PCT/US1987/003399 1986-12-23 1987-12-23 Lung cytotoxic peptides WO1988004666A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US156286A 1986-12-23 1986-12-23
US001,562 1986-12-23

Publications (2)

Publication Number Publication Date
WO1988004666A2 WO1988004666A2 (en) 1988-06-30
WO1988004666A3 true WO1988004666A3 (en) 1988-08-11

Family

ID=21696691

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1987/003399 WO1988004666A2 (en) 1986-12-23 1987-12-23 Lung cytotoxic peptides

Country Status (1)

Country Link
WO (1) WO1988004666A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066792A (en) * 1987-09-04 1991-11-19 Board Of Regents University Of Texas Gene probe for detection of specific human leukemias
KR20100056517A (en) * 2007-09-11 2010-05-27 몬도바이오테크 래보래토리즈 아게 Use of a peptide as a therapeutic agent

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0193351A2 (en) * 1985-02-25 1986-09-03 The Regents Of The University Of California Cationic oligopeptides having microbicidal activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0193351A2 (en) * 1985-02-25 1986-09-03 The Regents Of The University Of California Cationic oligopeptides having microbicidal activity

Also Published As

Publication number Publication date
WO1988004666A2 (en) 1988-06-30

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