WO1987007305A1 - Sequence adn codant l'oncogene ros, polypeptides codes a partir de celle-ci, et diagnostic et autres procedes bases sur cette sequence - Google Patents

Sequence adn codant l'oncogene ros, polypeptides codes a partir de celle-ci, et diagnostic et autres procedes bases sur cette sequence Download PDF

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Publication number
WO1987007305A1
WO1987007305A1 PCT/US1987/001215 US8701215W WO8707305A1 WO 1987007305 A1 WO1987007305 A1 WO 1987007305A1 US 8701215 W US8701215 W US 8701215W WO 8707305 A1 WO8707305 A1 WO 8707305A1
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WO
WIPO (PCT)
Prior art keywords
tumor
detecting
marker
oncogene
polypeptide
Prior art date
Application number
PCT/US1987/001215
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English (en)
Inventor
Michael H. Wigler
Carmen Birchmeier
Ottavio Fasano
Daniel Birnbaum
Original Assignee
Cold Spring Harbor Laboratory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cold Spring Harbor Laboratory filed Critical Cold Spring Harbor Laboratory
Publication of WO1987007305A1 publication Critical patent/WO1987007305A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Definitions

  • the invention concerns a DNA sequence comprising an activated oncogene which encodes a polypeptide capable of transforming NIH3T3 cells and of inducing a tumor when injected into nude mice, and further said polypeptide having tyrosine-specific protein kinase activity, said DNA sequence having a nucleotide sequence substantially as shown in Figure 1.
  • a serum-based method for detecting a tumor in a subject comprises isolating serum from the subject, contacting the serum with a first detectable marker which binds specifically to at least a portion of a polypeptide of this invention and detecting the marker so bound.
  • the presence of bound marker indicates the presence of a tumor.
  • the first detectable marker is preferably a labelled antibody which may be free, i.e. in a solution, or may be bound to a matrix, i.e. a matrix such as polystyrene beads or the wall of a tube.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Séquence ADN comprenant un oncogène activé, ledit oncogène codant un polypeptide capable de transformer des cellules NIH3T3 et d'induire une tumeur lorsqu'il est injecté dans des souris nues, ledit polypeptide ayant une activité de kinase de protéine spécifique à la tyrosine. L'invention concerne également une molécule de polypeptide codée par un oncogène activé, ladite molécule ayant les propriétés de transformer les cellules NIH3T3, d'induire une tumeur lorsqu'il est injecté dans des souris nues et d'agir comme une kinase de protéine spécifique à la tyrosine. Finalement, cette invention décrit un procédé de traitement d'une tumeur induite par un oncogène ros1 activé.
PCT/US1987/001215 1986-05-21 1987-05-21 Sequence adn codant l'oncogene ros, polypeptides codes a partir de celle-ci, et diagnostic et autres procedes bases sur cette sequence WO1987007305A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86556986A 1986-05-21 1986-05-21
US865,569 1986-05-21
US4891587A 1987-05-19 1987-05-19
US048,915 1987-05-19

Publications (1)

Publication Number Publication Date
WO1987007305A1 true WO1987007305A1 (fr) 1987-12-03

Family

ID=26726666

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1987/001215 WO1987007305A1 (fr) 1986-05-21 1987-05-21 Sequence adn codant l'oncogene ros, polypeptides codes a partir de celle-ci, et diagnostic et autres procedes bases sur cette sequence

Country Status (3)

Country Link
EP (1) EP0267275A4 (fr)
JP (1) JPH01500481A (fr)
WO (1) WO1987007305A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0337498A2 (fr) * 1988-04-15 1989-10-18 Montefiore Medical Center Procédé pour la détermination de l'état de progression d'une maladie
WO1990008160A1 (fr) * 1989-01-20 1990-07-26 Imperial Cancer Research Technology Ltd. Peptides analogues a des recepteurs de facteur de croissance ne presentant pas d'activite de tyrosine kinase
EP0408675A1 (fr) * 1988-08-19 1991-01-23 City Of Hope Detection de la progression et de la resistance aux medicaments de tumeurs chez l'homme
EP0455460A2 (fr) * 1990-05-01 1991-11-06 E.R. SQUIBB & SONS, INC. Tyrosine kinase négative TRKB
US6696548B2 (en) * 1993-12-03 2004-02-24 St. Jude Children's Research Hospital Antibodies for recognition of alk protein tyrosine/kinase receptor
EP2333103A1 (fr) * 2009-12-11 2011-06-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Diagnostic différentiel et thérapie pour les inhibiteurs de la kinase
WO2011070150A1 (fr) 2009-12-11 2011-06-16 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Nouvelles cibles pour le traitement de maladies prolifératives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA84617B (en) * 1983-02-14 1984-09-26 Arup Sen Synthetic polypeptides from viryl oncogenes

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Vol. 101, No. 23, issued 03 December 1984, (Columbus, OH) O.FASANO et al "New Human Transforming Genes Detected by a Tumorigenicity Assay" see page 141, column 2, the Abstract No. 205162e, Mol. Cell. Biol. 1984 4(9),1695-705 (Eng.) *
CHEMICAL ABSTRACTS, Vol. 104, No. 9, issued 03 March 1986 (Columbus, OH) J.J.M. VAN DONGEN et al, "Immunoglobulin Chain Gene Expression in Burkitt Lymphoma Derived Cell Lines" see page 184, column 2, the Abstract No. 63206h, UCLA Symp. Mol. Cell. Biol., New Ser. 1985 28, 481-489 (Eng.) *
Journal of Virology, Vol. 53, No. 3, issued March, 1985 (Washington, D.C) W.S. NECKAMEYER et al "Nucleotide Sequence of Avian Sarcoma Virus UR2 and Comparison of Its Transforming Gene with Other Members of the Tyrosine Protein Kinase Oncogene Family" see page 879. *
Molcular and Cellular Biology, Vol. 6, No. 9, issued September 1986 (Washington, D.C.), C. BIRCHMEIER et al "Characterization of an Activated Human ros Gene" see pages 3109, 3111 and 3114 *
Molecular and Cellular Biology, Vol. 6, No. 5, issued May 1986, (Washington, D.C.), W.S. NECKAMEYER et al "Proto-Oncogene c-ros Codes for a Molcule with Structural Features Common to those of Growth Factor Receptors and Displays Tissue-Specific and Development Regulated Expression" see pages 1478 and 1484. *
Proceedings National Academy of Sciences, USA, Vol. 83, No. 5, issued September, 1986 (Washington, D.C.) L. NAGARAJAN et al "The Human c-Ros Gene (ROS) is Located at Chromosome Region 6q16-6q22" see pages 6568, 6570 and 6571. *
See also references of EP0267275A4 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0337498A3 (fr) * 1988-04-15 1991-03-20 Montefiore Medical Center Procédé pour la détermination de l'état de progression d'une maladie
US5569584A (en) * 1988-04-15 1996-10-29 Montefiore Medical Center Method for distinguishing or monitoring the state of premalignant or malignant transformed human colonic tissue
EP0337498A2 (fr) * 1988-04-15 1989-10-18 Montefiore Medical Center Procédé pour la détermination de l'état de progression d'une maladie
EP0408675A4 (en) * 1988-08-19 1993-12-29 Kevin J. Scanlon Detection of human tumor progression and drug resistance
EP0408675A1 (fr) * 1988-08-19 1991-01-23 City Of Hope Detection de la progression et de la resistance aux medicaments de tumeurs chez l'homme
JPH04500458A (ja) * 1988-08-19 1992-01-30 シティ・オブ・ホープ ヒトの腫瘍進行と薬剤耐性の検出
WO1990008160A1 (fr) * 1989-01-20 1990-07-26 Imperial Cancer Research Technology Ltd. Peptides analogues a des recepteurs de facteur de croissance ne presentant pas d'activite de tyrosine kinase
EP0455460A3 (en) * 1990-05-01 1992-04-22 E.R. Squibb & Sons, Inc. Tyrosine kinase negative trkb
EP0455460A2 (fr) * 1990-05-01 1991-11-06 E.R. SQUIBB & SONS, INC. Tyrosine kinase négative TRKB
US6696548B2 (en) * 1993-12-03 2004-02-24 St. Jude Children's Research Hospital Antibodies for recognition of alk protein tyrosine/kinase receptor
EP2333103A1 (fr) * 2009-12-11 2011-06-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Diagnostic différentiel et thérapie pour les inhibiteurs de la kinase
WO2011070148A1 (fr) 2009-12-11 2011-06-16 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Diagnostic et thérapie différentiels pour inhibiteurs de kinase
WO2011070150A1 (fr) 2009-12-11 2011-06-16 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Nouvelles cibles pour le traitement de maladies prolifératives
EP2336171A1 (fr) * 2009-12-11 2011-06-22 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Nouvelles cibles pour le traitement des maladies proliférantes

Also Published As

Publication number Publication date
EP0267275A1 (fr) 1988-05-18
JPH01500481A (ja) 1989-02-23
EP0267275A4 (fr) 1989-09-19

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