WO1987005029A3 - Peptides affecting blood pressure regulation - Google Patents

Peptides affecting blood pressure regulation Download PDF

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Publication number
WO1987005029A3
WO1987005029A3 PCT/US1987/000367 US8700367W WO8705029A3 WO 1987005029 A3 WO1987005029 A3 WO 1987005029A3 US 8700367 W US8700367 W US 8700367W WO 8705029 A3 WO8705029 A3 WO 8705029A3
Authority
WO
WIPO (PCT)
Prior art keywords
val
aib
glu
pro
blood pressure
Prior art date
Application number
PCT/US1987/000367
Other languages
French (fr)
Other versions
WO1987005029A1 (en
WO1987005029A2 (en
Inventor
Terence K Brunck
Clarence B Colby Jr
Original Assignee
Triton Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Triton Biosciences Inc filed Critical Triton Biosciences Inc
Publication of WO1987005029A1 publication Critical patent/WO1987005029A1/en
Publication of WO1987005029A2 publication Critical patent/WO1987005029A2/en
Publication of WO1987005029A3 publication Critical patent/WO1987005029A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/14—Angiotensins: Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Peptides of formula (I), wherein NH is the alpha amino group of amino acid AA1; (II) is the carbonyl group of amino acid AA7; X is H-, (III), GLU-VAL-, or VAL-TYR-HIS-GLU-VAL; Y is -OH, -NH2, or -PRO; AA1 is LYS, GLU, GLN, pGLU, betaALA, PRO, PRO-OH, PIC, or AIB; AA2 is VAL, LEU, ILE, MET, or AIB; AA3 is ASP, TYR, GLU, HIS, or PHE; AA4 is VAL, MET, ILE, LEU, or AIB; AA5 is TYR, HIS, or GLU; AA6 is ALA, PRO, SER, betaALA, PRO-OH, or AIB; and AA7 is VAL, LEU, ILE, or AIB; and salts thereof are claimed as effective blood pressure regulators. Further provided, are antibodies to these peptides, as well as diagnostic and therapeutic methods for blood pressure regulation.
PCT/US1987/000367 1986-02-19 1987-02-19 Peptides affecting blood pressure regulation WO1987005029A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US83079586A 1986-02-19 1986-02-19
US830,795 1986-02-19
US229887A 1987-01-20 1987-01-20
US002,298 1987-01-20

Publications (3)

Publication Number Publication Date
WO1987005029A1 WO1987005029A1 (en) 1987-08-27
WO1987005029A2 WO1987005029A2 (en) 1987-08-27
WO1987005029A3 true WO1987005029A3 (en) 1987-11-19

Family

ID=26670201

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1987/000367 WO1987005029A2 (en) 1986-02-19 1987-02-19 Peptides affecting blood pressure regulation

Country Status (3)

Country Link
EP (1) EP0294390A1 (en)
AU (1) AU595597B2 (en)
WO (1) WO1987005029A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989011657A1 (en) * 1988-05-25 1989-11-30 Cambridge Research Biochemicals Limited Assay for oncogene expression

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986005208A1 (en) * 1985-03-01 1986-09-12 Board Of Regents, The University Of Texas System Polypeptides complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known and methods of design therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986005208A1 (en) * 1985-03-01 1986-09-12 Board Of Regents, The University Of Texas System Polypeptides complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known and methods of design therefor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Volume 104, 1986, (Columbus, Ohio, US), C.H.J. CHOU et al.: "Monoclonal Antibodies to Human Myelin Basic Protein", see page 548, Abstract 107567h, & J. Neurochem. 1986, 46(1), 47-53 *

Also Published As

Publication number Publication date
EP0294390A1 (en) 1988-12-14
AU595597B2 (en) 1990-04-05
AU7125887A (en) 1987-09-09
WO1987005029A2 (en) 1987-08-27

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