WO1986007537A3 - Pharmaceutical compositions containing azanaphthalenes - Google Patents

Pharmaceutical compositions containing azanaphthalenes

Info

Publication number
WO1986007537A3
WO1986007537A3 PCT/US1986/001298 US8601298W WO8607537A3 WO 1986007537 A3 WO1986007537 A3 WO 1986007537A3 US 8601298 W US8601298 W US 8601298W WO 8607537 A3 WO8607537 A3 WO 8607537A3
Authority
WO
WIPO (PCT)
Prior art keywords
azanaphthalenes
pharmaceutical compositions
compositions containing
formula
azanaphtalenes
Prior art date
Application number
PCT/US1986/001298
Other languages
French (fr)
Other versions
WO1986007537A2 (en
Inventor
Sidney Randall Smith
Marvin Ira Siegel
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/808,404 external-priority patent/US4945095A/en
Priority claimed from US06/839,308 external-priority patent/US4666922A/en
Priority claimed from US06/871,691 external-priority patent/US4801589A/en
Application filed by Schering Corp filed Critical Schering Corp
Priority to AT86904018T priority Critical patent/ATE51150T1/en
Priority to DE8686904018T priority patent/DE3669656D1/en
Priority to JP61503480A priority patent/JPH0676322B2/en
Publication of WO1986007537A2 publication Critical patent/WO1986007537A2/en
Publication of WO1986007537A3 publication Critical patent/WO1986007537A3/en
Priority to SG925/92A priority patent/SG92592G/en
Priority to HK93592A priority patent/HK93592A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Use of Azanaphtalenes of formula Ia, Ib or Ic wherein Ac is formula A'c or A''c, for the preparation of medicaments for suppressing the immune response.
PCT/US1986/001298 1985-06-18 1986-06-18 Pharmaceutical compositions containing azanaphthalenes WO1986007537A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AT86904018T ATE51150T1 (en) 1985-06-18 1986-06-18 MEDICINAL COMPOSITIONS CONTAINING AZANAPHTHALENE.
DE8686904018T DE3669656D1 (en) 1985-06-18 1986-06-18 MEDICINAL COMPOSITIONS CONTAINING AZANAPHTHALENE.
JP61503480A JPH0676322B2 (en) 1985-06-18 1986-06-18 Pharmaceutical composition containing azanaphthalene
SG925/92A SG92592G (en) 1985-06-18 1992-09-11 Pharmaceutical compositions containing azanaphthalenes
HK93592A HK93592A (en) 1985-06-18 1992-11-26 Pharmaceutical compositions containing azanaphthalenes

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US74614985A 1985-06-18 1985-06-18
US746,149 1985-06-18
US808,404 1985-12-12
US06/808,404 US4945095A (en) 1985-12-12 1985-12-12 Method for suppressing the immune response
US839,308 1986-03-13
US06/839,308 US4666922A (en) 1985-06-18 1986-03-13 Method for modulating the immune response
US06/871,691 US4801589A (en) 1986-06-12 1986-06-12 Method for suppressing the immune response
US871,691 1986-06-12

Publications (2)

Publication Number Publication Date
WO1986007537A2 WO1986007537A2 (en) 1986-12-31
WO1986007537A3 true WO1986007537A3 (en) 1987-03-26

Family

ID=27505636

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1986/001298 WO1986007537A2 (en) 1985-06-18 1986-06-18 Pharmaceutical compositions containing azanaphthalenes

Country Status (6)

Country Link
EP (1) EP0228416B1 (en)
JP (1) JPH0676322B2 (en)
CA (1) CA1261754A (en)
DE (1) DE3669656D1 (en)
SG (1) SG92592G (en)
WO (1) WO1986007537A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5350755A (en) * 1986-12-05 1994-09-27 Schering Corporation Compounds and methods for treating hyperproliferative skin disease
CA1309658C (en) * 1986-12-05 1992-11-03 David J. Blythin Pharmaceutical compositions for treatment of hyperproliferate skin disease
GB0614471D0 (en) 2006-07-20 2006-08-30 Syngenta Ltd Herbicidal Compounds
JP4495201B2 (en) 2007-10-10 2010-06-30 シャープ株式会社 Image processing apparatus, image forming apparatus, image processing method, image processing program, and recording medium for recording image processing program
CN114163446B (en) * 2021-12-16 2023-11-21 中山大学 PDE4 inhibitor with quinolinone skeleton and preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127135A2 (en) * 1983-05-31 1984-12-05 Schering Corporation Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones
EP0144996A2 (en) * 1983-12-14 1985-06-19 Schering Corporation Substituted spiro pyridine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions
EP0092786B1 (en) * 1982-04-26 1987-01-07 Schering Corporation 1,8-naphthyridine and 1,5,8-azanaphthyridine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5854152B2 (en) * 1976-03-25 1983-12-02 久光製薬株式会社 Novel naphthyridine derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0092786B1 (en) * 1982-04-26 1987-01-07 Schering Corporation 1,8-naphthyridine and 1,5,8-azanaphthyridine derivatives
EP0127135A2 (en) * 1983-05-31 1984-12-05 Schering Corporation Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones
EP0144996A2 (en) * 1983-12-14 1985-06-19 Schering Corporation Substituted spiro pyridine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Volume 88, No. 15, 10 April 1978, (Columbus, Ohio, US), see page 570, Abstract 105298y, & JP, A, 77116495 (Hisamitsu Pharmaceutical Co. Inc.) 29-09-1977 cited in the application *
Goodman and Gilman's : "The Pharmacological Basis of Therapeutics", 7th edition 1985, MacMillan Publishing Company, (New York, US), pages 674-676, see pages 674-676 *

Also Published As

Publication number Publication date
JPH0676322B2 (en) 1994-09-28
EP0228416A1 (en) 1987-07-15
DE3669656D1 (en) 1990-04-26
SG92592G (en) 1992-12-04
CA1261754A (en) 1989-09-26
EP0228416B1 (en) 1990-03-21
JPS63500100A (en) 1988-01-14
WO1986007537A2 (en) 1986-12-31

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