WO1986005399A1 - Pharmaceutical preparations or blood fluidification - Google Patents

Pharmaceutical preparations or blood fluidification Download PDF

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Publication number
WO1986005399A1
WO1986005399A1 PCT/FR1986/000089 FR8600089W WO8605399A1 WO 1986005399 A1 WO1986005399 A1 WO 1986005399A1 FR 8600089 W FR8600089 W FR 8600089W WO 8605399 A1 WO8605399 A1 WO 8605399A1
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WO
WIPO (PCT)
Prior art keywords
atrox
venom
combination
bothrops
venoms
Prior art date
Application number
PCT/FR1986/000089
Other languages
French (fr)
Inventor
Pascal Berdal
Original Assignee
Pascal Berdal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pascal Berdal filed Critical Pascal Berdal
Publication of WO1986005399A1 publication Critical patent/WO1986005399A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum

Definitions

  • TITLE pharmaceutical preparations which thin the blood:
  • the present innovation consists in combining in the same medicament at least two constituents chosen from a different group from the following groups: anticoagulants and (or) platelet antiaggregants; serum and / or anti-tissue antibodies; venoms and / or toxins; tissue extracts; substances previously known as procoagulant agents.
  • venoms and (or) toxins the venoms of élaps corallinus, naja tripudians, naja nigricollis, vipera aspis, vipéra bitis, vipera daboia, vipera torva, crotalus horridus, lachesis mutus, lachesis alternatus, bothrops atrox atrox, scorpio europeus, scorpio palmatus, prionurus australis, apis mellifica, apium virus, vespa crabo, vespa bombo, latrodectus mactans; as well as extracts (e.g. protein fractions) of venoms and toxins and (or) the corresponding antisera.
  • extracts e.g. protein fractions
  • procoagulant substances thrombin, fibrin, fibrinogen, coagulation factors, phospholipids, platelets, platelet extracts and other coagulation activators.
  • procoagulant substances thrombin, fibrin, fibrinogen, coagulation factors, phospholipids, platelets, platelet extracts and other coagulation activators.
  • thrombin acetylsalicylic acid (dose less than or equal to one gram per day) venom of bothrops lanceolatus
  • Example 2 acetylsalicylic acid venom of bothrops lanceolatus serum and (or) antibodies against blood platelets
  • the presentations of these drugs can be solid or liquid under all Possible pharmaceutical forms prepared according to methods known to those skilled in the art.
  • the active principles can be incorporated into all possible vehicles and excipients used in pharmaceutical compositions. Venoms, sera, antibodies, procoagulant substances will be used at a dilution greater than or equal to the third decimal dilution.

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present drugs are particularly intended to develop a blood fluidifying activity and are defined by the association of at least two constituents selected in different groups amongst the following groups. The platelet antiaggregants and(or) the anticoagulants; the antitissue antibodies and(or) the serums; the prior known substances as procoagulant substances.

Description

TITRE :préparations pharmaceutiques fluidifiant le sang: Dans le but d'obtenir des produits développant notamment une activité pharmacologique antithrombosante plus complète grâce à l'association de produits ayant des sites d'action complémentaires ou différents, la présente innovation consiste à associer dans le même médicament au moins deux constituants choisis dans un groupe différent parmi les groupes suivants: les anticoagulants et (ou) les antiaggregants plaquettaires; les serums et (ou) anticorps antitissus;les venins et(ou) les toxines;les extraits tissulaires;les substances antérieurement connues en tant qu' agents procoagulants. TITLE: pharmaceutical preparations which thin the blood: With the aim of obtaining products developing in particular a more complete anti-thrombotic pharmacological activity thanks to the association of products having complementary or different sites of action, the present innovation consists in combining in the same medicament at least two constituents chosen from a different group from the following groups: anticoagulants and (or) platelet antiaggregants; serum and / or anti-tissue antibodies; venoms and / or toxins; tissue extracts; substances previously known as procoagulant agents.
Citons â titre d'exemples non limitatifs: -dans le groupe des antiaggregants plaquettaires :l'acide acétylsalicylique -dans le groupe des anticoagulants:l'héparineAs non-limiting examples, let us cite: -in the group of platelet antiaggregants: acetylsalicylic acid -in the group of anticoagulants: heparin
-dans le groupe des serums et (où) des anticorps antitissus:les serums et (ou) les anticorps antiplaquettes sanguines-in the group of sera and (where) anti-tissue antibodies: sera and (or) antibodies against blood platelets
-dans le groupe des venins et (ou) des toxines:les venins de élaps corallinus, naja tripudians, naja nigricollis,vipera aspis, vipéra bitis,vipera daboia,vipera torva, crotalus horridus, lachesis mutus, lachesis alternatus,bothrops atrox atrox, scorpio europeus, scorpio palmatus,prionurus australis, apis mellifica, apium virus,vespa crabo,vespa bombo, latrodectus mactans;aisi que les extraits (par exemple:les fractions protéiques) des venins et toxines et (ou) les antisérums correspondants.-in the group of venoms and (or) toxins: the venoms of élaps corallinus, naja tripudians, naja nigricollis, vipera aspis, vipéra bitis, vipera daboia, vipera torva, crotalus horridus, lachesis mutus, lachesis alternatus, bothrops atrox atrox, scorpio europeus, scorpio palmatus, prionurus australis, apis mellifica, apium virus, vespa crabo, vespa bombo, latrodectus mactans; as well as extracts (e.g. protein fractions) of venoms and toxins and (or) the corresponding antisera.
-dans le groupe des substances actuellement connues en tant que substances procoagulantes:la thrombine, la fibrine, le fibrinogène, les facteurs de coagulation, les phospholipides, les plaquetes, les extraits plaquettaires et autres activateurs de la coagulation. Les quelques exemples non limitatifs donnés ci-après ne font qu'illustrer l'innovation sans la limiter.Ils ne constituent que quelques exemples particuliers. Exemple I: acide acétylsalicylique (dose inférieure ou égale à un gramme par jour) venin de bothrops lanceolatus Exemple 2 : acide acétylsalicylique venin de bothrops lanceolatus sérum et (ou) anticorps antiplaquettes sanguines Les présentations de ces médicaments peuvent être solides ou liquides sous toutes les formes pharmaceutiques possibles préparées selon les méthodes connues de l'homme de l'art.Les principes actifs peuvent y être incorporés à tous les véhicules et excipients possibles employés dans les compositions pharmaceutiques.Les venins, les sérums, les anticorps, les substances procoagulantes seront utilisés à une dilution supérieure ou égale à la troisième dilution décimale. -in the group of substances currently known as procoagulant substances: thrombin, fibrin, fibrinogen, coagulation factors, phospholipids, platelets, platelet extracts and other coagulation activators. The few nonlimiting examples given below only illustrate innovation without limiting it, they are only a few specific examples. Example I: acetylsalicylic acid (dose less than or equal to one gram per day) venom of bothrops lanceolatus Example 2: acetylsalicylic acid venom of bothrops lanceolatus serum and (or) antibodies against blood platelets The presentations of these drugs can be solid or liquid under all Possible pharmaceutical forms prepared according to methods known to those skilled in the art. The active principles can be incorporated into all possible vehicles and excipients used in pharmaceutical compositions. Venoms, sera, antibodies, procoagulant substances will be used at a dilution greater than or equal to the third decimal dilution.

Claims

REVENDICATIONS I-Médicament destiné à fluidifier le sang et(uo) à développer une activité antiinflammatoire et (ou) antalgique, caractérisé en ce qu'il est constitué par une association d'au moins deux constituants choisisdans un groupe différent parmi les groupes suivants:les antiaggregants plaquettaires et (ou) les anticoagulants, les serums et (ou) les anticorps antitissus et (ou) les extraits tissulaires, les venins,les substances antérieurement connues comme agents procoagulants.CLAIMS I-Medication intended to thin the blood and (uo) to develop an anti-inflammatory and (or) analgesic activity, characterized in that it is constituted by a combination of at least two constituents chosen from a different group from the following groups: platelet antiaggregants and / or anticoagulants, serums and / or anti-tissue antibodies and / or tissue extracts, venoms, substances previously known as procoagulant agents.
2-Médicament selon la revendication I caractérisé en ce qu'il contient un antiaggrégant plaquettaire (tel que par exemple 1' acide acétylsalicylique) et (ou) un anticoagulant (tel que par exemple l'héparine), associé (s) à un ou plusieurs venins (s) (tel (s) crue le venin de bothrops atrox atrox ou bothrops lanceolatus, raja nigricollis, lachesis mutus, lâchesis alternatus,crotalus horridus,crotalus cascavella,vipera aspis, apis mellifica,vespa crabo,vespa bombo,naja tripudians, lachesis neuwidii,vipera daboia, vipera torva, latrodectus mactans,elaps corallinus) et (ou) aux extraits et fractions des venins et (ou) aux antisérums contre les venins et (ou) leurs fractions. 3-Médicament selon la revendication I caractérisé par l'association d'un antiaggrégant plaquettaire tel que l'acide acétylsalicylique avec le venin de bothrops lanceolatus.2-medicament according to claim I characterized in that it contains an antiplatelet agent (such as for example 1 acetylsalicylic acid) and (or) an anticoagulant (such as for example heparin), associated (s) with one or several venoms (such as raw) the venom of bothrops atrox atrox or bothrops lanceolatus, raja nigricollis, lachesis mutus, lâchesis alternatus, crotalus horridus, crotalus cascavella, vipera aspis, apis mellifica, vespa crabo, vespa bombo, naja trip , lachesis neuwidii, vipera daboia, vipera torva, latrodectus mactans, elaps corallinus) and / or extracts and fractions of venoms and (or) antisera against venoms and (or) their fractions. 3-A drug according to claim I characterized by the combination of an antiplatelet agent such as acetylsalicylic acid with the venom of bothrops lanceolatus.
4-Médicament selon la revendication I caractérisé par l'association d'un antiaggrégant plaquettaire tel que l'acide acétylsalicylique et (ou) un anticoagulant tel que l'héparine avec le venin de bothrops atrox atrox et le sérum et (ou) les anticorps anti-plaquettes sanguines.4-A drug according to claim I characterized by the combination of an antiplatelet agent such as acetylsalicylic acid and (or) an anticoagulant such as heparin with the venom of bothrops atrox atrox and serum and (or) antibodies anti-platelets.
5-Médicament selon la revendicarion I caractérisé par l'association d'un antiaggrégant plaquettaire et (ou) un anticoagulant 6-Médicament selon la revendication I caractérisé par l'association d'au moins un venin tel que le venin de bothrops atrox atrox et le sérum et(ou) les anticorps antiplaquettes sanguines. 7-Médicament selon la revendication I caractérisé en ce qu'il comprend une ou plusieurs substance (s) choisie (s) dans le groupe des substances connues antérieurement comme agents procoagulants telle (s) que par exemple:la fibrine, le fibrinogène, la thrombine, les facteurs de coagulation, les plaquettes et leurs traits, le collagène, les phospholipides, les inhibiteurs de la fibrinolyse.5-Drug according to claim I characterized by the combination of an antiplatelet agent and / or an anticoagulant 6-medicament according to claim I characterized by the combination of at least one venom such as the venom of bothrops atrox atrox and the serum and (or) antibodies to blood platelets. 7-medicament according to claim I characterized in that it comprises one or more substance (s) chosen (s) from the group of substances previously known as procoagulant agents such as (s) such as for example: fibrin, fibrinogen, thrombin, coagulation factors, platelets and their traits, collagen, phospholipids, fibrinolysis inhibitors.
8-Composition pharmaceutique caractérisée en ce qu'elle contient une quantité efficace du médicament selon l'une quelconque des revendications précédentes en association avec un véhicule pharmaceutiσuement acceptable. 8-Pharmaceutical composition characterized in that it contains an effective amount of the medicament according to any one of the preceding claims in association with a pharmaceutically acceptable vehicle.
PCT/FR1986/000089 1985-03-18 1986-03-17 Pharmaceutical preparations or blood fluidification WO1986005399A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8503965A FR2578745B1 (en) 1985-03-18 1985-03-18 BLOOD FLUIDIFYING PHARMACEUTICAL PREPARATIONS
FR85/03965 1985-03-18

Publications (1)

Publication Number Publication Date
WO1986005399A1 true WO1986005399A1 (en) 1986-09-25

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EP (1) EP0215876A1 (en)
AU (1) AU5625786A (en)
FR (1) FR2578745B1 (en)
WO (1) WO1986005399A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555109B1 (en) * 1998-01-20 2003-04-29 S.I.S. Shulov Institute For Science Ltd. Analgesic from snake venom
JP2008509990A (en) * 2004-08-16 2008-04-03 メディカル リサーチ ファンド アット ザ テル アビブ ソウラスキー メディカル センター Methods and compositions for modulation of systemic inflammatory response syndrome (SIRS)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4140981B2 (en) * 1994-12-26 2008-08-27 東菱薬品工業株式会社 Anti-restenosis and arteriosclerosis drug
JP3742675B2 (en) * 1995-06-28 2006-02-08 東菱薬品工業株式会社 Prophylactic and therapeutic agents for ischemia-reperfusion injury

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1157593A (en) * 1967-01-26 1969-07-09 Expl De Marques Et Brevets S E Pharmaceutical Composition Containing Detoxicated Snake Venom.
FR2222083A1 (en) * 1973-03-22 1974-10-18 Fontaine Michel
FR2487201A2 (en) * 1980-03-24 1982-01-29 Pasteur Institut Immunological agent prepn. by chemically bonding antigen to lymphocyte - using glutaraldehyde or benzoquinone as linking agent e.g. tetanus, diphtheria, leukaemia vaccines, hyperimmune serums for analysis etc.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1157593A (en) * 1967-01-26 1969-07-09 Expl De Marques Et Brevets S E Pharmaceutical Composition Containing Detoxicated Snake Venom.
FR2222083A1 (en) * 1973-03-22 1974-10-18 Fontaine Michel
FR2487201A2 (en) * 1980-03-24 1982-01-29 Pasteur Institut Immunological agent prepn. by chemically bonding antigen to lymphocyte - using glutaraldehyde or benzoquinone as linking agent e.g. tetanus, diphtheria, leukaemia vaccines, hyperimmune serums for analysis etc.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555109B1 (en) * 1998-01-20 2003-04-29 S.I.S. Shulov Institute For Science Ltd. Analgesic from snake venom
JP2008509990A (en) * 2004-08-16 2008-04-03 メディカル リサーチ ファンド アット ザ テル アビブ ソウラスキー メディカル センター Methods and compositions for modulation of systemic inflammatory response syndrome (SIRS)

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Publication number Publication date
FR2578745A1 (en) 1986-09-19
AU5625786A (en) 1986-10-13
EP0215876A1 (en) 1987-04-01
FR2578745B1 (en) 1989-05-12

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