WO1979000811A1 - Dispositif d'etude du tube alimentaire - Google Patents

Dispositif d'etude du tube alimentaire Download PDF

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Publication number
WO1979000811A1
WO1979000811A1 PCT/DK1979/000011 DK7900011W WO7900811A1 WO 1979000811 A1 WO1979000811 A1 WO 1979000811A1 DK 7900011 W DK7900011 W DK 7900011W WO 7900811 A1 WO7900811 A1 WO 7900811A1
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WO
WIPO (PCT)
Prior art keywords
mass
chamber
fluid
fact
valve
Prior art date
Application number
PCT/DK1979/000011
Other languages
English (en)
Inventor
J Pawelec
Original Assignee
J Pawelec
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK133478A external-priority patent/DK133478A/da
Application filed by J Pawelec filed Critical J Pawelec
Priority to DE19792943225 priority Critical patent/DE2943225A1/de
Publication of WO1979000811A1 publication Critical patent/WO1979000811A1/fr
Priority to DK495379A priority patent/DK495379A/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/07—Endoradiosondes
    • A61B5/073—Intestinal transmitters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/0061—Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions

Definitions

  • This invention relates to sampling devices for automatically obtaining samples of gastric and intestinal fluids in the digestive tracts of humans and animals and for use in determining the presence of free hydrochloric acid and lactic acid in the gastric fluids.
  • clonten s of the different parts of the gastrointestinal tract plays a great role in diagnostic and medical research. Information from these examinations can be of great impor ⁇ tance for diagnosing diseases of stomach, duodenum, gallbladder and pancreas, as well as for diagnosing certain blood diseases.
  • the determination of the presence or absence of free hydrochloric acid and lactic acid in the digestive tract is especially important and useful.
  • the absence of free hydrochloric acid in the gastric fluid is a character ⁇ istic finding of pernicious anemia.
  • the absence of hydro ⁇ chloric acid together with the presence of lactic acid in the gastric fluid indicates for advanced carcinoma of the stomach.
  • Stomach tubes are the normal instruments for col ⁇ lecting samples of the contents of the stomach and duodeum. As is known, these are long, flexible tubes wich are inser ⁇ ted to the digestive tractc through the patient's mouth or nose, and then fluid from the actual part of the digestive tract is aspirated through the tube. The examination normally takes place under x-ray control, to check for proper positioning of the end of the tube in the digestive tract.
  • test results may be inconclusive or erroneous.
  • Intubation of the digestive tract is an expensive examination. It is a very time-consuming examination for the doctor, and demands the help of highly qualified nurses, a suitable place with comfortable beds where the patients can be examined, and access to x-ray apparatus. The examination immobilizes the patient for several hours, and exposes him to the risks of x-ray exposure.
  • the present invention provides a sampling device for automatically obtaining samples of gastric and/or intestinal fluids and for use in determining the presence of free hydrochloric acid and lactic acid in the digestive tracts of humans or animals.
  • the device is similar in size and shape to a conventional pharmaceutical capsule and is thus suitable for ingestion.
  • the capsule defines an inner fluid receiving chamber having an entrance which is normally sealed off from the external environment by way of a blocking mechanism including a mass which, upon contact with a certain fluid present in the digestive tract causes the mechanism to " communicate the opening with the outside of the capsule allowing a sample of the fluid to enter and be retained in the chamber.
  • a cylindrical spring operated valve normally maintained in a flow permit ⁇ ting position by a mass which glues the necessary parts of the valve together in such a way that the parts cannot move, so the action of the strained spring is neutralized. This mass is also responsive to contact with the fluid to permit the valve to operate and seal off the chamber after a predetermined time.
  • the sample is then secured from contami ⁇ nation during its further travel through the rest of the di ⁇ gestive tract, and the capsule is evacuated by a normal defectory process and recovered to be sent to a laboratory for analysis of the sample.
  • the collected samples can be . used for chemical, biochemical, microbiological, parasito- logical and cytological examination.
  • the sampling device of the present invention used in collecting a sample of gastric fluids is equiped with mechanisms, which control the opening and closing of the capsule, and which are blocked by a mass, which can for example comprise gelatin, saccarose or another carbohydrate, which loses its blocking properties after a short time following contact with the gastric fluid.
  • a mass which can for example comprise gelatin, saccarose or another carbohydrate, which loses its blocking properties after a short time following contact with the gastric fluid.
  • the opening of the capsule, the collection of the sample and reclosing of the capsule takes place in the stomach.
  • Capsule D-duodenum With the use of a different mass, which for example comprises celluloseacetatephtalate which will no dissolve until after contact with the alkaline contents o the small intestine, the capsule ( Capsule D-duodenum) ma be used to collect a sample of intestinal fluids.
  • the capsule additionally contains a basic-acid indicator in the chamber, which res ponds to free HC1 in the gastric fluid to cause a color • change in the fluid sample, indicating the presence of fr HC1 in the sample (Capsule A-acidity).
  • a part of the wall the capsule is made of transparent material to permit viewing of the sample contained therein.
  • indicator sesitive to lactic acid may be disposed in the chamber to react with the fluid sample, and provide a cha in color of the sample, indicating the presence of lactic acid in the sample (Capsule LA-lactic acid) .
  • first and second spring achanisms control the ⁇ opening of the capsule and then its closing.
  • the spring mechanisms initially neutralized by a mass that secures parts of the capsule* together, in such a way that the mechanisms canno operate. In this configuration, the entrance to the caps chamber is normally kept closed off.
  • the mass which blocks these mechanism has such properties that after it contacts gastro or intestinal fluid, depending on the application and thus type of mass used, its characteristics are altered in such a way that loses the properties that permit it to secure the parts o the device together and prevent operation of the capsule' mechanisms.
  • a portion of the mass which normally neutral zes the action of the first spring mechanism is disposed externally of the capsule. Accordingly, when the capsule is swallowed by the patient and the portion of the mass contacts the gastro ( or intestinal ) fluid, its properti are altered allowing the first spring mechanism to operat This expands the capsule, enlarging the capacity of its
  • OMPI inner chamber and aspirating a sample of the fluid into the chamber.
  • the expanding of the capsule causes exposure of a place covered by a second portion of the mass, which normally neutralizes the action of the second spring means, to the fluid being sampled.
  • the second mass loses the properties which enable it to neutralize operation of the second spring mechanism. This permits a valve to operate and close the capsule, hermetically sealing it. With the fluid sample enclosed therewithin and isolated from contamination during its way through the rest of the digestive tract.
  • the present invention it is possible to examine the gastric and duodenal fluids without any stress, discomfort and pain of intubation obviates the need for x-ray exposure and x-ray equipment, and immobilization of . the patient for several hours in bed.
  • the examination can be performed independently of the patient's state of health.
  • Examination using the principles of the present invention is so simple to perform, that the patient can do part of the examination (according to doctor's instruc ⁇ tions) himsef -in his own home, with no need for expensive medical care.
  • the examination which can be made by the help of the new invention, open new possibilites for diagnostic and research, and can lead to a better knowledge of the physiology and biochemistry of the digestive process.
  • the fluid sampling device of the present invention can play an especially large role in mass- examinations of the digestive tract for finding cancer alterations because it is inexpensive and easy to use.
  • FIG. 1 is in axial section view of one embodimen of the sampling capsule device in initial position.
  • FIG. 2 is a sectional view taken along lines 2-2 of FIG. 1;
  • FIG. 3 is a sectional view taken along the lines 3-3 of FIG. 1;
  • FIG. 4 is a sectional view taken along the lines 4-4 of FIG. 1;
  • FIG. 5 is a sectional view taken along the lines 5-5 of FIG. 1;
  • FIGS. 6 and 7 are breakaway views showing the capsule of FIG. 1 in two different working positions
  • FIG. 8 is a perspective view of the capsule with the bottom portion of the capsule removed;
  • FIG. 9 is a perspective view of the inner shell member of the capsule of FIG. 1;
  • FIG. 10 is a side elevation view, partially in section of a second embodiment of the capsule.
  • FIG..11 is a breakaway view of a third embodimen of the capsule.
  • FIGS. 12 and 13 are sectional views of a fourth embodiment of the capsule illustrating unoperated and operated configurations, respectively;
  • FIG. 14 is a sectional view of a fifth embodimen of the capsule.
  • FIGS. 15 and 16 are sectional views of a sixth embodiment of" the capsule illustrating unoperated and operated configuration, respectivly;
  • FIG. 17 is a sectional view taken along lines 17-17 of FIG. 15;
  • FIGS. 18 and 19 are sectional views of a seventh embodiment of the capsule illustrating unoperated and operated configurations, respectively.
  • FIGS. 20 and 21 are sectional views of a eighth embodiment of the capsule illustrating unoperated and operated configurations, respectively.. DESCRIPTION OF PREFERRED EMBODIMENTS
  • the sampling device basically comprises a capsule having an outer shell member' 1 and an inner shell member 2 which is received in telescopic- engagement with the outer shell member defining an enclosed chamber 18.
  • FIG. 1 which illustrates the device in its closed configuration
  • an aperture or- window 17, shown best in FIG. 9, formed in the side.-wall of the inner shell member 2 is normally sealed off or- closed by the inner wall of the outer shell member 1.
  • shell members 1 and 2 are securated together by mass 21 neutralizing the effect of a compressed spring 19, extending axially within compartment 18, and which tends to drive the two shell members apart.
  • the mass 21 loses its effectiveness as a holding agent. This permits the shell members to be driven apart under the force of the spring 19, so that as the walls of the two shell members slide along one another, eventually aperture 17 is communicated with the outside of the capsule, as shown in FIG. 6, allowing fluid, such as intestinal or gastric fluid, to be aspirated into chamber 18.
  • a spring operated valve assembly including valve member 9 and valve operating spring 25, is mounted within the capsule.
  • the valve operates a short time after the capsule expands and the fluid contacts mass 28 changing its characteristics. When operated, the valve closes the capsule by rotating aperture 16 out of alignment with aperture 17, as shown in FIG, 7, hermetically sealing
  • OMPI the capsule with the fluid contained within the chamber thereof.
  • the device in shape of a capsule and size of 8 X 19 mm, is able to collect about 1 ml of intestinal flu Using microanalysis, this is sufficient quantity to perfor many different analysis.
  • the mass that is used depends upon- the ' function application of the capsule. If the capsule is used to collecting gastric fluid, the machanisms that guide the opening and closing of the capsule, hereinafter referred t as capsule G (Gastric) are blocked by a mass which loses i blocking properties after short contact with the gastric fluid.
  • the opening of the capsule, the collection of the sample and the closing takes place in stomach.
  • the mass may be comprised of gelatin, proteins, gum arabic, saccharose or other carbohydrates. hot solutions of these substances after stiffening creates mass, which secures or holds together appropriate parts of the capsule in a way to effectively neutralize the action springs.
  • Such mass loses its properties which enable it t hold these parts together after a short contact with the g tric fluid. For example, depending on the composition of mass, it may become brittle causing it to fracture under force of the spring it normally neutralizes, or the mass m dissolve freeing the parts it normally holds together.
  • the capsule may also be used to collect intestin fluid, in which case the mass is comprised of cellulose- acetate phtalate, shellac, polyvinyl chloride or polymers polyvinylpyridine acril acid.
  • capsule D duodenum
  • the block mass or substance is not submitted to any change in the stomach. Its change occurs only after contact with the al line contents of the small intestine. It is pointed out t capsule D mechanisms can use that same mass as that used f the capsule, that mass being covered with a film or . coating comprising celluloseacetatephtalate, shellac, polyvinyl chloride or polymers of polyvinylpyridineacri acid which resist gastric fluids.
  • the outer shell 1 has a bottom or cover 3 which is connected to the main body portion of the shell 1 for example, by way of screw threads (not shown) and with vacuum grease indicated at 4 providing a seal between the bottom member and the main body portion.
  • Bottom 3 is provided to simplify assembly of the working mechanisms of the capsule during manufacture and to facilitate access to the sample of gastric fluid stores in the chamber 18 after use of the device to enable analysis of the sample.
  • Shell members 1 and 2 are so fit together and tightened by help of vacuum grease or 0-rings, to create a hermetically sealed capsule.
  • the bottom 3 has an opening 5 filled with a plug 6 which allows air to be evacuated from chamber 18 as by iserting a needle probe of suitable vacuum pump or syringe through plug 6, providing an under pressure in chamber 18.
  • the plug 6 is of material having characteristics providing self sealing when the needle is withdrawn.
  • the inner shell 2 has a neck 7 extending per ⁇ pendicular to a horizontal wall 8, hereinafter referred to as the base of the neck. As shown best in FIG. 9, the height of the neck, which is of hollow cylindrical confi ⁇ guration, is differentiated with the circumference of the upper portion of the neck having a stepped configuration defining- stop surfaces 30a and 30b. Under the base of neck
  • valve sleeve 8 is placed the cylindrical valve sleeve 9.
  • valve sleeve 9 and the neck base 8 have central apertures 10 and 11 of the same inner diameters which makes it possible to thread them onto the shank of a pivot pin 12.
  • the valve sleeve 9 is permanently connected to pin 12 in a suitable manner, such as by a layer of epoxy 13.
  • the inner shell 2, which threaded onto the pin 12, can rotate freely around the axis of pin 12.
  • a header 14 which can rotate
  • Header 14 is permanently connected to pin 12 such as by a layer of epoxy 15. In this way, the rotation of the header 14 around neck 7 causes the rotatio of sleeve 9 around the inner ahell 2. Header 14, pin 12, sleeve 9 and torque 25 form the valve mechanism of the capsule.
  • the inner shell 2 has rectangular window 17 form in its side wall and it has the same shape and size as win 16 formed in the side wall of the valve sleeve 9.
  • the winndows- 16 and 17 are disposed so that in the initial condition (FIGS. 1 and 5) the valve is in flow permiting position and the capsule is in its closed and compressed position, with the openings in alignment with one another. In this position, the chamber 18 is out of communication w the external environment because windows 16 and 17 are cov by the inner wall of outer shell 1.
  • the spring 19 which extends within chamber 18 has its bottom end permanently fastened to bottom member 3, for example by layer of epoxy 20. The top end of the spring engages the under surface o valve sleeve 9. When the capsule is in the closed positio the spring 19 is compressed, exerting a force along the longitudinal axis of the capsule tending to separate shell 1 and 2.
  • chamber 18 When the capsule expands, chamber 18 is enlarged to almost twice its initial capacity and is communicated with the environment through the openings 16 and 17 (FIG. 6) which are uncovered as the result of the separating movement of members 1 and 2. As result of the underpressure in chamber 18, the gastric fluid will aspirate into the inner of chamber 18 through the openings 16 and 17.
  • valve sleeve 9 is moved from the opening 17 in the wall of the inner shell 2 (FIG. 7), causing the capsule to be closed to the environment.
  • the sample of gastric fluid in the chamber 18 is thus sealed in and is secured of contamination as the capsule continues its way through the rest of the digestive tract.
  • the turning of valve sleeve 9 around the inner ahell 2 is limited to 180° by a stop member 29 fastened to header 14, and which engages a vertical surface 30a of neck 7 (FIG. l). At its other extreme of travel, stop member 29 engages surface 30b of the neck 7 as shown in FIG. 2.
  • the capsule After the capsule has passed through the digesti tract, it is recovered from the fecies and washed, and the sent to a laboratory for analysis of the sample. In the laboratory, bottom 3 and spring 19 fastened to 3 are remov as shown in FIG. 8, and the rest of the capsule serves as tube which encloses the sample for use by the clinical technician during testing.
  • the outer shell 1 has opening 31, which has the same diameter as an opening 32 formed in header 14 and an opening 33 formed in neck 7.
  • the openings 31, 32, 33 and pin 34 (FIG.5) simplify set-up of the capsule.
  • torque spring 25 is first wound by rotating head 14 180° around neck 7 until the opening 32 and 33 overlap and it is possible to insert peg 34 through the openings.
  • the layer of mass 28 is applied, and when becomes set, the peg 34 is removed.
  • the inner shell is slid along the outer shell 1 until the openings 31 and are aligned, and it is possible to pass peg 34 through the Then the layer of mass 21 is applied and after it becomes set, the peg 34 is removed.
  • the set-up of the capsule is finished by inserting the spring 19 in chamber 18 and the ring spring 23, and securing the bottom 3 on the main body portion of the outer shell 1.
  • the capsule can be used to detect the present of free HC1 in the gastric fluid.
  • Capsule A is constructed identically with capsul G, with the difference that in its inner chamber 18, a container 35, which is secured to or formed integrally wit the bottom of pin 12, holds a small quantity of a basic- acid indicator which upon contact with free HC1 in the fluid sample received in chamber 18 causes a color change of the fluid sample also.
  • a portion of the walls of the shell members 1 and 2 of capsule A is made of transparent material so that the color change is: visible through the
  • OMPI WIPO transparent wall of the capsule On the basis of the color of the sample, a determination can be made as to the normal or unnormal composition of the patient's gastric fluid.
  • indicator of free HCl which can be used is • dimetylaminoazobenzol which may be in powdered form.
  • the _ powder is covered with a film of gelatin to delay exposure of the indicator to the fluid until after the valve operates to close the chamber.
  • the capsule may be used to determine the presence of lactic acid in the gastric juice.
  • Tis cap ⁇ sule referred as capsule LA lactic acid
  • capsule LA lactic acid
  • the indicator when contacting lactic acid in the sample of gastric fluid, causes coloring of the sample characteristic of the presence of lactic acid.
  • Such indicator is covered this same film as capsule A.
  • the color of the sample may be viewed through the transparent wall of the capsule to determine the existence or non-existence of lactic acid in the gastric fluid of the patient.
  • an indicator of la ⁇ tic acid which can be used is Fe Cl ⁇ .
  • a paper or other sorbent which contains or is saturated with suit ⁇ able chemicals may be used.
  • FIG. 11 there is shown a further embodiment of the capsule having two separate fluid storage chambers 18a and 18b each having an associated valve mechanism simi ⁇ lar- to that used in capsule G, for example.
  • Each section of the capsule is similar to that described with reference to the embodiment of FIG. 1 with the mass 21 and 28 that neut ⁇ ralizes the spring 19, embodied as a flat power spring, and valve member 9, respectively, for one of the chambers 18a, being the type responds to gastric fluid, and the mass associated with the other chamber 18b being the type that responds to intestinal fluids.
  • the stop member 29 wich limits rotation of valve sleeve 9 extends from the side wall of the header 14.
  • this capsule may be used to obtain samples of both gastric fluid and intestinal fluid, or may use the same mass but different indicators forming a combination capsule A and LA.
  • the operation and construct of the sampling device is apparent from foregoing descrip ⁇ tion. It is apparent that one or both of the chambers may be provided with an indicator, as in capsule A or LA, the mass for each section of the device being selected in accordance with its intended use.
  • capsule chamber 18 is defined in part by a container 38 of an elastic material, which is normally folded up and contained, along with a valve mechanism within a capsule shaped container 46 of a material that is isoluable in fluids of the alimentary canal.
  • the valve mechanism is similar to that employed in the capsule G shown and described above with reference to FIG. 1.
  • the container 38 is hermetically sealed to the bas of the inner shell member at points 49. ⁇ he opening to the chamber 18, is defined by window 16 in valve sleeve 9 and window 17 in the side wall of the inner shell member 2A.
  • the envelope 46 which can be made of material insoluble i alimentary canal's fluids, consists of at least two parts 46a and 46b which are glued together by means of mass 21 which after contact with a suitable fluid of alimentary ca loses the properties that glued the parts 46a and 46b together. Consequently, the envelope breaks apart, allowi the elastic- container 38 to expand as shown in FIG. 13.
  • the valve is normally maintaine in fluid permitting condition so that when the capsule bre away, and the container expands, fluid is aspirated into chamber 18 due to the vaccum created as the container 38 expands.
  • the cover 46 can also be made of material that is soluable in suitable fluids of the alimentary canal. It is pointed out that the container 38 may be of other configurations
  • O P such as a bellows-shaped, normally compressed and expandible coaxially of the capsule.
  • FIG. 14 there is shown a further embodiment in which the mass 21 is employed to seal the entrance way 65 to the openings 53 and 54 of the inner cham ⁇ ber 18.
  • mass 21 changes its properties, fluid is permitted to flow into the chamber through openings 53 and 54 and when received within the chamber 18 will cause mass 28 and 64 to changes its properties and allow the valve mechanism to rotate and close the openind 54.
  • a hollow shell member 50 is permanently connected to a flange 55 at the base of a header 6 " by a layer of epoxy 57, applied circumferentially, which also seals the shell and the header at the connection.
  • the inner chamber 18 is communicated with the external environment through openings 53 and 54 formed in the side walls of the valve sleeve 58 and the header 56, respectively, and a channel 65 provided by spacing between the capsule 50 and the valve sleeve 56. Channel 65 is normally blocked by mass 21.
  • valve sleeve 58 is secured to the header 5o " by mass 28, with openings 53 and 54 being in register, and the action of valve spring 60, which is wound up, being neutralized.
  • the spring 60 tends to rotate the sleeve 58 around a pivot pin 61, the shank of which is fixedly received in an aperture 62 formed in the underside of the header 56.
  • a further mass 64 secures the valve sleeve to the pin 61, which is permanently connected to the head 56 by means of a layer of epoxy 62.
  • One end of spring 60 is secured to the pin 61 and other end is secured to the valve sleeve 58 so that when the spring is torqued, the spring tends to rotate the sleeve to move opening 53 out of register with opening 54.
  • the spring action is effectively neutra ⁇ lized by the mass 28 and the mass 64.
  • a suitable stop means limits rotational movement of the valve member in the manner of stop means 29 shown in FIG. 1.
  • This- device does not use the expansion principle
  • OMPI employed in the device of FIG. 1 and may- be evacuated to establish an under pressure in the chamber 18 prior to use employing a syringe the needle of which is insertable throu suitable self sealing plug 66.
  • Notches 70 in the side of the container 50 provid break away points for removing the valve assembly and the rest of the capsule serves as a tube which contains the sample for use by the clinical technician during testing.
  • mass 21 changes i properties which otherwise permit it to block the entrance channel 65 to the chamber 18, and a sample of the fluid is aspirated into the chamber 18.
  • the fluid contacts mas 28 and mass 64 they lose their properties which permitted them to neutralize the operation of the valve.
  • the valve sleeve then rotates under the force of spring 60 to move opening 53 out of register with opening 54 to seal off the chamber 18 with the fluid sample retained therewith.
  • FIGS. 15-17 there is shown a further embodimen of the capsule.
  • the capsule has the inner chamber 18 which is communicated with the external environment through openings 17a and 17b formed in the side wall of the capsule
  • the chamber there are two discs 91 and 93 made of such material as metal or plastic.
  • the disc 91 is permanently connected to the seal 92 and the disc 93 is per nently connected to tne sea l 94.
  • the discs 91 and 93 divide the chamber 18 into three portions, 18a, 18b and 18c.
  • an underpressure is establishe through self-sealing plug 6a and in the chamber 18c an overpressure is established through the plug 6b.
  • the seal 92 tends to aspirate a sample of the fluid from the environment and the seal 94 tends to close the openings 17a and 17 " b.
  • the suction effect of the underpres ⁇ sure is blocked by a mass 21b which glues together the wall of the capsule and the disc 91. in such a way that the seal 92 cannot move.
  • the effect of the overpressure is blocked by a mass 28 which blocks the movement of the seal 94.
  • the openings 17a and 17b are covered by a mass 21a.
  • mass 21a changes its properties which otherwise permit it to block the openings 17a and 17b, and sample of the fluid is permitted to flow into the chamber 18b and when received within the chamber 18b will cause mass 21b and 28 to change its properties which blocked the movement of the the seals 92 and 94.
  • the layer of the mass 28 is much more thick than the layer of the mass 21b causing that the mass 21b is removed as the first one. This permits the under ⁇ pressure to move the seal 92 and to collect the sample of the fluid, and then the overpressure in the chamber 18c is able to move the seal 94 and close the capsule, herm ⁇ etically sealing it as shown in FIG. 16.
  • FIGSv- 18 and 19 a modification of the capsule in wich the capsule chamber 18 is defined in part by bellows-shaped container 95.
  • the closing means is similar to that employed in the capsule shown and described above with reference to FIGS. 15-17, but the overpressure is replaced by the compressed spring 97, and the underpressure is replaced by the spring means 96 and said bellows-shaped container.
  • the envelope 21 is similar to that employed in the capsule shown and described above with reference to FIG. 12.
  • the envelope 21 breaks apart, allowing the bellows-shaped . ' container 95 to expand as shown in FIG. 19.
  • the sample of fluid is aspirated into the chamber 18a due to the under ⁇ pressure created as the container expands.
  • the mass 28 which blocks operation of the spring 97, it changes its properties, allowing the seal 94 to close the openings 17a and 17b as shown in FIG. 19.
  • FIGS. 20 and 21 a modification of the device similar to the device shown in FIGS. 18 and 19.
  • the compressed spring 106 tends to close the opening 104 through which the inner chamber is communicable with the exterior of the device.
  • the round block 109 situated between the seal 1 and the O-ring 108 blocks the action of the compressed spri 106 and keeps the opening 104 in the open position.
  • the block 109 is permanently connected with the bottom of the bellows-shaped container 102 by means of the thread 110.
  • the length of the thread 110 is shorter than the length of the expanded device.
  • the envelope 21 which covers the opening 104 and keeps the spri 105 i the compressed state and keeps the container 102 in i tense position breaks apart and provokes the expansion of the container 102, suction of the body fluid, removal of th block 109 and closing of the opening 104, as shown in FIG.2

Abstract

Capsule a avaler pour obtenir des echantillons de fluides gastriques et/ou intestinaux, la capsule definissant une chambre de reception (18) d'un fluide ayant un orifice d'entree (17) qui est normalement ferme et isole de l'exterieur de la capsule avec des moyens d'obstruction consistant en une masse (21) dont les proprietes changent au contact des fluides appropries presents dans l'appareil digestif, ce qui provoque la communication a travers l'orifice d'entree (17) entre l'exterieur de la capsule et la chambre de reception (18) ou un echantillon de fluide est aspire. Dans la chambre se trouvent des moyens de fermeture (9, 12, 14) normalement maintenus en position permettant l'ecoulement par une masse (28) qui colle les parties necessaires des moyens de fermeture ensemble de telle maniere qu'elles ne puissent pas bouger, de sorte que l'action des moyens de fermeture soit neutralisee. Cette masse (28) est sensible au contact des fluides appropries du tube digestif pour permettre aux moyens de fermeture (9, 12, 14) de fermer la chambre (18) de maniere a ce que l'echantillon soit protege contre la contamination pendant la suite de son parcours a travers le reste de l'appareil digestif. En utilisant une masse differente (21, 28) qui se dissoudra dans le suc gastrique ou qui ne se dissoudra qu'apres contact avec le contenue alcalin du grale intestin, la capsule peut etre utilisee pour obtenir un echantillon de suc gastrique ou de suc intestinal. Un indicateur d'HC1 libre, ou alternativement d'acide lactique, peut etre contenu dans la chambre (18) de la capsule; cet indicateur reagit en presence d'HC1 libre, ou d'acide lactique dans l'echantillon pour changer la couleur de l'echantillon, ce qui permet de le voir a travers une partie transparente de la paroi de la capsule.
PCT/DK1979/000011 1978-03-22 1979-03-21 Dispositif d'etude du tube alimentaire WO1979000811A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19792943225 DE2943225A1 (de) 1978-03-22 1979-03-21 Device for study of the alimentary canal
DK495379A DK495379A (da) 1978-03-22 1979-11-22 Indtrument til undersoegelse af fordoejelseskanalen

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK133478A DK133478A (da) 1976-12-08 1978-03-22 Instrument til undersoegelse af fordoejelseskanalen og fremgangsmaade til anvendelse af instrumentet
DK1334/78 1978-03-22
US91037078A 1978-05-30 1978-05-30

Publications (1)

Publication Number Publication Date
WO1979000811A1 true WO1979000811A1 (fr) 1979-10-18

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PCT/DK1979/000011 WO1979000811A1 (fr) 1978-03-22 1979-03-21 Dispositif d'etude du tube alimentaire

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EP (1) EP0014202A1 (fr)
GB (1) GB2039219B (fr)
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Cited By (11)

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WO1988000449A1 (fr) * 1986-07-11 1988-01-28 C.B. Bioelettronica S.R.L. Sonde oesophagienne pourvue d'electrodes de mesure ou de stimulation
CN102920418A (zh) * 2012-10-24 2013-02-13 刘思德 一种消化道自稳探路胶囊
WO2014140334A1 (fr) * 2013-03-15 2014-09-18 Mars, Incorporated Dispositif d'échantillonnage
CN106999166A (zh) * 2014-09-17 2017-08-01 马斯公司 装置
FR3052046A1 (fr) * 2016-06-07 2017-12-08 Univ Grenoble Alpes Dispositif de prise d'echantillon intestinal
US10172598B2 (en) 2012-02-17 2019-01-08 Progenity, Inc. Ingestible medical device
WO2019113259A1 (fr) 2017-12-06 2019-06-13 James Phillip Jones Système de capsule de prélèvement
CN110087530A (zh) * 2016-12-07 2019-08-02 普罗根尼蒂公司 胃肠道检测方法、装置和系统
CN110167451A (zh) * 2016-09-28 2019-08-23 Biome牛津有限公司 用于胃肠材料采样的装置
CN110650688A (zh) * 2017-05-19 2020-01-03 蒂达尔·沙隆 用于收集胃肠道样本的装置和方法
US11007356B2 (en) 2018-11-19 2021-05-18 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract

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US20190223846A1 (en) * 2016-09-15 2019-07-25 Progenity, Inc. Fluid Sampling Device
CN113440172B (zh) * 2021-07-27 2022-08-30 新疆维吾尔自治区人民医院 一种基于互联网的消化道采样胶囊

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US3118439A (en) * 1957-04-09 1964-01-21 Perrenoud Jean-Pierre Diagnostic and medicating capsule and the method of use
US3485235A (en) * 1967-12-04 1969-12-23 Ronald Felson Capsule for the study and treatment of the digestive tract
GB1302548A (fr) * 1969-07-28 1973-01-10
US3719183A (en) * 1970-03-05 1973-03-06 H Schwartz Method for detecting blockage or insufficiency of pancreatic exocrine function
US4036214A (en) * 1975-04-14 1977-07-19 Louis Bucalo Fluid-collecting and microorganism-detecting devices

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US3118439A (en) * 1957-04-09 1964-01-21 Perrenoud Jean-Pierre Diagnostic and medicating capsule and the method of use
US3057344A (en) * 1957-05-21 1962-10-09 Abella Carlos Alberto Capsule for the study of the digestive tract and method of using the same
US3485235A (en) * 1967-12-04 1969-12-23 Ronald Felson Capsule for the study and treatment of the digestive tract
GB1302548A (fr) * 1969-07-28 1973-01-10
US3719183A (en) * 1970-03-05 1973-03-06 H Schwartz Method for detecting blockage or insufficiency of pancreatic exocrine function
US4036214A (en) * 1975-04-14 1977-07-19 Louis Bucalo Fluid-collecting and microorganism-detecting devices

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000449A1 (fr) * 1986-07-11 1988-01-28 C.B. Bioelettronica S.R.L. Sonde oesophagienne pourvue d'electrodes de mesure ou de stimulation
US10172598B2 (en) 2012-02-17 2019-01-08 Progenity, Inc. Ingestible medical device
CN102920418A (zh) * 2012-10-24 2013-02-13 刘思德 一种消化道自稳探路胶囊
WO2014140334A1 (fr) * 2013-03-15 2014-09-18 Mars, Incorporated Dispositif d'échantillonnage
CN105050500A (zh) * 2013-03-15 2015-11-11 马斯公司 采样装置
JP2016514987A (ja) * 2013-03-15 2016-05-26 マース インコーポレーテッドＭａｒｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 検体採取機器
JP2019150587A (ja) * 2013-03-15 2019-09-12 マース インコーポレーテッドＭａｒｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 検体採取機器
CN106999166A (zh) * 2014-09-17 2017-08-01 马斯公司 装置
FR3052046A1 (fr) * 2016-06-07 2017-12-08 Univ Grenoble Alpes Dispositif de prise d'echantillon intestinal
US11931013B2 (en) 2016-06-07 2024-03-19 Universite Grenoble Alpes Device for taking an intestinal sample
CN109890298A (zh) * 2016-06-07 2019-06-14 格勒诺布尔-阿尔卑斯大学 肠道样本采集装置
CN109890298B (zh) * 2016-06-07 2022-05-27 格勒诺布尔-阿尔卑斯大学 肠道样本采集装置
WO2017211872A1 (fr) * 2016-06-07 2017-12-14 Universite Grenoble Alpes Dispositif de prise d'échantillon intestinal
CN110167451A (zh) * 2016-09-28 2019-08-23 Biome牛津有限公司 用于胃肠材料采样的装置
CN110167451B (zh) * 2016-09-28 2023-10-20 Biome牛津有限公司 用于胃肠材料采样的装置
US11547301B2 (en) 2016-12-07 2023-01-10 Biora Therapeutics, Inc. Methods for collecting and testing bacteria containing samples from within the gastrointestinal tract
CN110087530A (zh) * 2016-12-07 2019-08-02 普罗根尼蒂公司 胃肠道检测方法、装置和系统
CN110650688B (zh) * 2017-05-19 2023-12-22 恩维沃生物股份有限公司 用于收集胃肠道样本的装置和方法
CN110650688A (zh) * 2017-05-19 2020-01-03 蒂达尔·沙隆 用于收集胃肠道样本的装置和方法
JP2021142330A (ja) * 2017-05-19 2021-09-24 シャロン、ティドハー 胃腸サンプルを採取するためのデバイスおよび方法
US11766249B2 (en) 2017-05-19 2023-09-26 Envivo Bio Inc. Devices and methods for collecting gastrointestinal samples
EP3720425A4 (fr) * 2017-12-06 2021-08-25 James Phillip Jones Système de capsule de prélèvement
CN111712234B (zh) * 2017-12-06 2023-09-08 詹姆斯·菲利普·琼斯 采样胶囊系统
CN111712234A (zh) * 2017-12-06 2020-09-25 詹姆斯·菲利普·琼斯 采样胶囊系统
WO2019113259A1 (fr) 2017-12-06 2019-06-13 James Phillip Jones Système de capsule de prélèvement
US11439802B2 (en) 2018-11-19 2022-09-13 Biora Therapeutics, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
US11007356B2 (en) 2018-11-19 2021-05-18 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract

Also Published As

Publication number Publication date
EP0014202A1 (fr) 1980-08-20
GB2039219A (en) 1980-08-06
GB2039219B (en) 1982-10-06

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