WO1979000135A1 - Methode et dispositif de manipulation des prises de sang - Google Patents

Methode et dispositif de manipulation des prises de sang Download PDF

Info

Publication number
WO1979000135A1
WO1979000135A1 PCT/SE1978/000041 SE7800041W WO7900135A1 WO 1979000135 A1 WO1979000135 A1 WO 1979000135A1 SE 7800041 W SE7800041 W SE 7800041W WO 7900135 A1 WO7900135 A1 WO 7900135A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
closure
blood
phases
cannula
Prior art date
Application number
PCT/SE1978/000041
Other languages
English (en)
Inventor
C Ericson
Original Assignee
C Ericson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C Ericson filed Critical C Ericson
Publication of WO1979000135A1 publication Critical patent/WO1979000135A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • B01L3/50215—Test tubes specially adapted for centrifugation purposes using a float to separate phases

Definitions

  • the present invention is concerned with a method of handling blood samples and a device for performing the method.
  • Known blood sample containers comprise test tubes of glass or plastic having a rounded or conical bottom. It is also known to have the test tubes sealed and a subatmospheric .pressure established therein whereby .filling is facilitated and filling up to a certain level is achieved.
  • a bloo sample is introduced by means of a cannula or the like into a preferably cylindrical container by piercing a first clo ⁇ sure provided in the one end surface of the container.
  • the method is characterized in that the blood-filled container i turned up and down and is subsequently centrifuged, causing a phase body introduced into the container to become sub ⁇ mersed to assume a position in which it separates the phases of the blood from each other, the phase to be analysed being removed by means of a cannula or the like from the container by piercing a second closure provided in the other end sur- face of the container.
  • the device for performing the method of the invention comprises a container for collecting blood, said container being adapted to receive a so-called phase body which after centrifuging the blood-filled container separates the blood phases from each other, characterized in that the container is an open tube,one end of which is closed by a sealing, pierceable first closure through which the blood sample is introduced, and the other end of which is closed by a sealin pierceable second closure through which one of the separated phases of the blood is removed.
  • a sub-atmospheric pressure is established in the device and at least one of t closures is so dimensioned that the sub-atmospheric pressur is indicated visually by the formation of a depression in said closure.
  • FIGURE 1 is a cross-sectional elevation of a container accor- ding to the invention during introduction of a blood sample with the aid of a cannula shown in the figure.
  • FIGURE 2 shows the container turned upside down prior to centrifuging of the blood sample.
  • FIGURE 3 shows the container of fig. 2 after centrifuging.
  • FIGURE 4 is a partial perspective view of a. first embodiment of one of the end closures of the container.
  • FIGURE 5 is a cross-sectional view taken on line V-V in fig. 4 of the end closure according to fig. 4.
  • FIGURES 6, 7 and 8 each show different embodiments of one of the end closures of the container.
  • FIGURES 9 and 10 each illustrate one of two different embodi ⁇ ments of the other end closure of the container.
  • Fig. 1 shows a test tube according to the present invention.
  • the test tube comprises a straight tube length 1 of glass, plastic or the like. Either end of the tube length is closed by a pierceable closure 2 and 3 respectively sealing against the tube wall either internally (closure 2) or externally (closure 3) .
  • a phase body 4 is provided within the tube length. The phase body does not constitute a part of the present in ⁇ vention and will accordingly not be described in detail.
  • a sub-atmospheric pressure is caused to prevail in the container which is indicated by the fact that the lower closure 3 in fig. 1 is inwardly curved.
  • the blood sample from a .patient is introduced into the container by means of a cannula 5 whic is caused to pierce the upper closure 2 as shown in fig. 1. Due to the sub-atmospheric pressure the test tube may be filled to a certain predetermined level, whereafter cannula 5
  • ⁇ 5 " ' is removed.
  • the container is marked to identify the blood-giver, e.g. by means of a label glued onto the container.
  • a label glued onto the container.
  • Fig. 2 illustrates the container of fig. 1 after removal of the cannula and turned upside down. In this position the con ⁇ tainer is centrifuged. During centrifuging the phase body due to its construction will always move more slowly than the
  • the phase body is of resilient material ahd when the final centrifugal force has been achieved the disc-like element 6 of the phase body will be directed upward ly and the phase body, in a way -known, will descent through the blood serum until a state of equilibrium is achieved.
  • Fig. 3 illustrates the container of fig. 2 after the end of . ' centrifuging with the phase body separating the serum or 5 plasma phase from the blood coagulum phase.
  • the container With the orien ⁇ tation as shown in fig. 3 the container is transferred to the analyzing station where the separated serum/plasma phase is recovered by piercing the closure 3.
  • the container according to the invention reduces the 0 risk of infection because the need for an additional transfer prior to analysis is eliminated.
  • the handling of the blood sample is completely secluded which means that the staff under no circumstances is required to take the risk of coming into contact with the blood sample.
  • work is saved 5 and the risk of exchange is reduced. Due to the fact that only one test tube is to be used also the turn-over of
  • f OM implements is reduced.
  • the container is a tube length, narrow manufacturing tolerances can be observed both in the tube length and the closures. It is a further advantage of the container of the invention that the losses of blood gases '* * solved in the blood serum are reduced. Also the risk of con ⁇ tamination is lowered.
  • Present-day readers of sample identi ⁇ fications require that the sample identification provided on the container has a.certain, exact orientation. As testing and sampling now can be made from one and the same container, such sample identification can be mechanically applied before ⁇ hand.
  • the closure 2 has a depression 7 facilitating penetration of the cannula. More ⁇ over, the closure has a plane upper surface 8 adapted to co- operate with centrifuge sleeves having a plane bottom. More ⁇ over, the closure has a conical internal portion 9 . Due to this shape the forces acting on the closure when serving as the bottom of the container during -centrifuging will exert a sealing action in respect to prior piercing of the closure.
  • Fig. 6 shows another embodiment of closure 2. Also this em ⁇ bodiment has a plane upper surface 8 and an internal conical portion 9 but in addition the closure is rounded as at 10.
  • the embodiment as shown in fig. 7 is similar to that of fig. 6 except that the lower side of the closure is rounded as at 11.
  • the embodiments according to figs. 6 and 7 are adapted to be used in connection with centrifuge sleeves having a rounded bottom.
  • the embodiment according to fig. 8 corresponds to the embodi ⁇ ment of closure 2 as shown in figs. 1 to 3.
  • a depression 12 corresponds to recess 7 as shown in figs. 4 to 7.
  • the bottom surface 13 of the closure is plane.
  • the closure according to fig. 9 corresponds to that shown in figs. 1 to 3 but is additionally provided with a lip 14 bv y gtT EAtT
  • OMPI means of which the closure can be removed.
  • a clo sure 3 is shown sealing internally within the tube length.
  • Either closure 2 and 3 may be glued, heat-sealed or other- wise disposed in either end of the tube length.
  • the closure may even be removable.
  • either closure must be made of self-sealing material re-sealing itself aft piercing and removal of a cannula or the like.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

La methode implique la manipulation en milieu ferme des prises de sang. Le dispositif d'application de la methode comprend un recipient pouvant contenir une prise de sang ainsi qu'un corps dit de phase (4) introduit au prealable dans le recipient qui, apres traitement centrifuge du recipient, separe les phases sanguines les unes des autres. Le recipient consiste en un tube (1) dont chaque extremite est bouchee par un element transpercable en assurant la fermeture hermetique (2 et 3 resp.). Le prelevement de sang est introduit au moyen d'une canule, par exemple, au travers de l'element de fermeture (2) et une des phase sanguines formee pendant le traitement centrifuge est retiree au travers de l'autre element de fermeture (3) au moyen d'une canule par exemple.
PCT/SE1978/000041 1977-09-08 1978-09-08 Methode et dispositif de manipulation des prises de sang WO1979000135A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE7710076A SE7710076L (sv) 1977-09-08 1977-09-08 Blodprovtagningsbehallare
SE7710076 1977-09-08

Publications (1)

Publication Number Publication Date
WO1979000135A1 true WO1979000135A1 (fr) 1979-03-22

Family

ID=20332209

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1978/000041 WO1979000135A1 (fr) 1977-09-08 1978-09-08 Methode et dispositif de manipulation des prises de sang

Country Status (3)

Country Link
EP (1) EP0001200A1 (fr)
SE (1) SE7710076L (fr)
WO (1) WO1979000135A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2553005A1 (fr) * 1983-10-06 1985-04-12 Terumo Corp Dispositif de filtration pour liquides
WO1987001457A1 (fr) * 1985-08-27 1987-03-12 Ersson Nils Olof Procede et dispositif pour separer le serum/plasma du sang
EP0753741A1 (fr) * 1995-01-30 1997-01-15 Niigata Engineering Co., Ltd. Element de separation de composants et separateur de composants equipe dudit element
US20150173660A1 (en) * 2011-10-20 2015-06-25 Becton, Dickinson And Company Blood Collection Assembly And Method for Use Thereof
US9393575B2 (en) 2000-04-28 2016-07-19 Harvest Technologies Corporation Blood components separator disk

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2218076A (en) * 1988-03-25 1989-11-08 William Thomas Dennis Bates Sample tube
CA2458497A1 (fr) 2004-02-24 2005-08-24 Cme Telemetrix Inc. Analyse spectrophotometrique de plasma ou de serum dans un tube scelle
EP3068304B1 (fr) * 2013-11-14 2017-08-09 Greiner Bio-One GmbH Dispositif de réception, procédé de production de celui-ci et procédé de séparation d'un mélange

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3706305A (en) * 1971-03-03 1972-12-19 Harold J Berger Combination blood sampling vacuum syringe centrifuge container and specimen cup
US3750645A (en) * 1970-10-20 1973-08-07 Becton Dickinson Co Method of collecting blood and separating cellular components thereof
GB1391053A (en) * 1972-02-27 1975-04-16 Sarstedt W Device for the extraction of blood
US3970565A (en) * 1973-11-27 1976-07-20 Aktiebolaget Stille-Werner Separating and filtering device
US4012325A (en) * 1975-01-08 1977-03-15 Eastman Kodak Company Biological fluid dispenser and separator
US4020831A (en) * 1975-12-04 1977-05-03 Technicon Instruments Corporation Blood collecting syringe
US4027660A (en) * 1976-04-02 1977-06-07 Wardlaw Stephen C Material layer volume determination

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR985250A (fr) * 1949-04-27 1951-07-16 Dispositif pour prise de sang
US3800780A (en) * 1972-02-23 1974-04-02 Angelika Elliott Vacuum indicator
US3930413A (en) * 1972-12-07 1976-01-06 Caterpillar Tractor Co. Quick release gauge fitting
US3951801A (en) * 1974-02-27 1976-04-20 Becton, Dickinson And Company Serum/plasma separator-strut stop type
US3931018A (en) * 1974-08-09 1976-01-06 Becton, Dickinson And Company Assembly for collection, separation and filtration of blood

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3750645A (en) * 1970-10-20 1973-08-07 Becton Dickinson Co Method of collecting blood and separating cellular components thereof
US3706305A (en) * 1971-03-03 1972-12-19 Harold J Berger Combination blood sampling vacuum syringe centrifuge container and specimen cup
GB1391053A (en) * 1972-02-27 1975-04-16 Sarstedt W Device for the extraction of blood
US3970565A (en) * 1973-11-27 1976-07-20 Aktiebolaget Stille-Werner Separating and filtering device
US4012325A (en) * 1975-01-08 1977-03-15 Eastman Kodak Company Biological fluid dispenser and separator
US4020831A (en) * 1975-12-04 1977-05-03 Technicon Instruments Corporation Blood collecting syringe
US4027660A (en) * 1976-04-02 1977-06-07 Wardlaw Stephen C Material layer volume determination

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2553005A1 (fr) * 1983-10-06 1985-04-12 Terumo Corp Dispositif de filtration pour liquides
WO1987001457A1 (fr) * 1985-08-27 1987-03-12 Ersson Nils Olof Procede et dispositif pour separer le serum/plasma du sang
US4853137A (en) * 1985-08-27 1989-08-01 Ersson Nils Olof Method and device for separating serum/plasma from blood
EP0753741A1 (fr) * 1995-01-30 1997-01-15 Niigata Engineering Co., Ltd. Element de separation de composants et separateur de composants equipe dudit element
EP0753741A4 (fr) * 1995-01-30 1998-04-29 Niigata Engineering Co Ltd Element de separation de composants et separateur de composants equipe dudit element
US9393575B2 (en) 2000-04-28 2016-07-19 Harvest Technologies Corporation Blood components separator disk
US9393576B2 (en) 2000-04-28 2016-07-19 Harvest Technologies Corporation Blood components separator disk
US9656274B2 (en) 2000-04-28 2017-05-23 Harvest Technologies Corporation Blood components separator disk
US20150173660A1 (en) * 2011-10-20 2015-06-25 Becton, Dickinson And Company Blood Collection Assembly And Method for Use Thereof
US10426391B2 (en) * 2011-10-20 2019-10-01 Becton, Dickinson And Company Blood collection cartridge, blood collection system, and blood collection method for use thereof

Also Published As

Publication number Publication date
EP0001200A1 (fr) 1979-03-21
SE7710076L (sv) 1979-03-09

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