UY37631A - INHIBITOR OF THE REGULATORY KINASE OF THE APOPTOSIS SIGNAL - Google Patents

INHIBITOR OF THE REGULATORY KINASE OF THE APOPTOSIS SIGNAL

Info

Publication number
UY37631A
UY37631A UY0001037631A UY37631A UY37631A UY 37631 A UY37631 A UY 37631A UY 0001037631 A UY0001037631 A UY 0001037631A UY 37631 A UY37631 A UY 37631A UY 37631 A UY37631 A UY 37631A
Authority
UY
Uruguay
Prior art keywords
inhibitor
apoptosis signal
regulatory kinase
compound
formula
Prior art date
Application number
UY0001037631A
Other languages
Spanish (es)
Inventor
Lynne Alleva Jennifer
Elodie DEMPAH Kassibla
Julie Farand
Gregory Notte
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of UY37631A publication Critical patent/UY37631A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

Se proporciona un compuesto de Fórmula (I) o una sal farmacéuticamente aceptable del mismo para uso en el tratamiento de esteatohepatitis no alcohólica, hepatitis alcohólica, hipertensión arterial pulmonar, insuficiencia cardíaca con fracción de eyección conservada y enfermedad renal diabética. También se proporcionan formas amorfas y cristalinas del compuesto de Fórmula (I) y sales, co-cristales, solvatos e hidratos del mismo.A compound of Formula (I) or a pharmaceutically acceptable salt thereof is provided for use in the treatment of non-alcoholic steatohepatitis, alcoholic hepatitis, pulmonary arterial hypertension, heart failure with preserved ejection fraction and diabetic kidney disease. Amorphous and crystalline forms of the compound of Formula (I) and salts, co-crystals, solvates and hydrates thereof are also provided.

UY0001037631A 2017-03-14 2018-03-14 INHIBITOR OF THE REGULATORY KINASE OF THE APOPTOSIS SIGNAL UY37631A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762471300P 2017-03-14 2017-03-14

Publications (1)

Publication Number Publication Date
UY37631A true UY37631A (en) 2018-09-28

Family

ID=61750538

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037631A UY37631A (en) 2017-03-14 2018-03-14 INHIBITOR OF THE REGULATORY KINASE OF THE APOPTOSIS SIGNAL

Country Status (6)

Country Link
AR (1) AR111178A1 (en)
BR (1) BR102018004862A2 (en)
JO (1) JOP20180017A1 (en)
TW (1) TW201840551A (en)
UY (1) UY37631A (en)
WO (1) WO2018169742A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI625121B (en) 2009-07-13 2018-06-01 基利科學股份有限公司 Apoptosis signal-regulating kinase inhibitors
IL270525B1 (en) * 2017-05-12 2024-02-01 Enanta Pharm Inc Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US10597382B2 (en) 2017-08-28 2020-03-24 Enanta Pharmaceuticals, Inc. Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
KR20210005195A (en) 2018-05-02 2021-01-13 이난타 파마슈티칼스, 인코포레이티드 Tetrazole comprising an apoptosis signal modulating kinase 1 inhibitor and methods of use thereof
WO2019213239A1 (en) 2018-05-02 2019-11-07 Enanta Pharmaceuticals Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
CN110818683B (en) * 2018-08-10 2023-04-14 中国科学院上海药物研究所 2-pyridine substituted urea structure small molecule compound and synthesis and application thereof
US10968199B2 (en) 2018-08-22 2021-04-06 Enanta Pharmaceuticals, Inc. Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US11345699B2 (en) 2018-11-19 2022-05-31 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2020198214A1 (en) 2019-03-25 2020-10-01 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2023125904A1 (en) * 2021-12-30 2023-07-06 苏州晶云药物科技股份有限公司 Crystal form of azacyclobutyl nicotinic acid compound and preparation method therefor
CN117503932A (en) * 2022-07-30 2024-02-06 中国医学科学院阜外医院 Use of Jun inhibitors for the preparation of a medicament for the treatment of heart failure with retained ejection fraction

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI625121B (en) 2009-07-13 2018-06-01 基利科學股份有限公司 Apoptosis signal-regulating kinase inhibitors
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
UY34573A (en) 2012-01-27 2013-06-28 Gilead Sciences Inc QUINASE INHIBITOR REGULATING THE APOPTOSIS SIGNAL
US20150342943A1 (en) 2014-06-03 2015-12-03 Gilead Sciences, Inc. Methods of treating liver disease
TW201618781A (en) 2014-08-13 2016-06-01 吉李德科學股份有限公司 Methods of treating pulmonary hypertension
MA41252A (en) * 2014-12-23 2017-10-31 Gilead Sciences Inc SOLID FORMS OF AN ASK 1 INHIBITOR

Also Published As

Publication number Publication date
TW201840551A (en) 2018-11-16
BR102018004862A2 (en) 2019-01-02
AR111178A1 (en) 2019-06-12
WO2018169742A1 (en) 2018-09-20
JOP20180017A1 (en) 2019-01-30

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Legal Events

Date Code Title Description
104 Application deemed to be withdrawn (no substantive examination fee paid)

Effective date: 20201204