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Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Abstract
La presente invención proporciona composiciones de anticuerpos, incluyendo, por ejemplo,anticuerpos, anticuerpos diseñados y fragmentos de anticuerpos que se unen a un miembro de la superfamilia del receptor del factor de necrosis tumoral (es decir, miembro 18). Las composiciones proporcionadas son útiles en la mejora de las respuestas de células T CD4 y CD8, y en el tratamiento, mejora y prevención de enfermedades que pueden ser contrarrestadas con una respuesta inmune aumentada, por ejemplo, cánceres. También se proporciona en la invención polinucleótidos y vectores que codifican dichas moléculas y células hospederas que albergan los polinucleótidos o vectores; así como composiciones farmacéuticas que comprenden tales moléculas, métodos y el uso de los mismos.The present invention provides antibody compositions, including, for example, antibodies, designed antibodies and antibody fragments that bind to a member of the tumor necrosis factor receptor superfamily (i.e., member 18). The compositions provided are useful in improving the responses of CD4 and CD8 T cells, and in the treatment, improvement and prevention of diseases that can be counteracted with an increased immune response, for example, cancers. Also provided in the invention are polynucleotides and vectors encoding said molecules and host cells that house the polynucleotides or vectors; as well as pharmaceutical compositions comprising such molecules, methods and the use thereof.
UY0001036344A2014-10-082015-10-06
COMPOSITIONS AND METHODS USED TO INCREASE THE IMMUNE RESPONSE AND IN CANCER THERAPY
UY36344A
(en)
binding molecules, one or more isolated polynucleotides, one or more vectors, host cell, method of producing a binding molecule, pharmaceutical composition, use of the binding molecule, method of treating disease and inducing target cell lysis
COMPOSITION, METHODS OF TREATMENT OF A HUMAN WHO HAS BEEN DIAGNOSED WITH CANCER, OF CANCER PREVENTION IN A HUMAN AT HIGH RISK OF RECEIVING CANCER, AND OF PRODUCING A COMPOSITION OF AN ISOLATED HUMAN ANTI-TUMOR NK CELL POPULATION AND A DENDRITIC CELL POPULATION HUMAN ANTITUMOR ISOLATED, HUMAN NK AND DENDRITIC CELLS ISOLATED, E, KIT