UY35743A - SYNTHESIS PROCEDURE FOR THE PREPARATION OF C1-CETO MACROCICLIC ANALOGS OF HALICONDRINE B AND USEFUL INTERMEDIARIES IN THE SAME - Google Patents

SYNTHESIS PROCEDURE FOR THE PREPARATION OF C1-CETO MACROCICLIC ANALOGS OF HALICONDRINE B AND USEFUL INTERMEDIARIES IN THE SAME

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Publication number
UY35743A
UY35743A UY0001035743A UY35743A UY35743A UY 35743 A UY35743 A UY 35743A UY 0001035743 A UY0001035743 A UY 0001035743A UY 35743 A UY35743 A UY 35743A UY 35743 A UY35743 A UY 35743A
Authority
UY
Uruguay
Prior art keywords
preparation
halicondrine
analogs
macrociclic
ceto
Prior art date
Application number
UY0001035743A
Other languages
Spanish (es)
Inventor
Fabio E S Souza
Jason A Bexrud
Gorin Boris
Rudolph Alena
Pan Ming
Ngooi Teng Ko
Orprecio Ricardo
Rangwala Huzaifa
Original Assignee
Alphora Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alphora Res Inc filed Critical Alphora Res Inc
Priority to UY0001035743A priority Critical patent/UY35743A/en
Publication of UY35743A publication Critical patent/UY35743A/en

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Abstract

Se describe un compuesto de fórmula 1, o una sal farmacéuticamente aceptable del mismo, donde R1, R2, R3, R4, R5, R6, R7, R7’, R8, R9, R10, R11, R12 y R13 son como se describe en la presente. También se describe un procedimiento para la preparación del compuesto de fórmula 1, o una sal farmacéuticamente aceptable del mismo, e intermediarios utilizados en el mismo. El compuesto de fórmula 1 puede ser utilizado en la preparación de análogos de Halicondrina, tales como Eribulina; y también se describe un procedimiento para su preparación a partir del compuesto de fórmula 1.A compound of formula 1, or a pharmaceutically acceptable salt thereof, is described, wherein R1, R2, R3, R4, R5, R6, R7, R7 ', R8, R9, R10, R11, R12 and R13 are as described in the present. A process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein is also described. The compound of formula 1 can be used in the preparation of Halicondrine analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also described.

UY0001035743A 2014-09-24 2014-09-24 SYNTHESIS PROCEDURE FOR THE PREPARATION OF C1-CETO MACROCICLIC ANALOGS OF HALICONDRINE B AND USEFUL INTERMEDIARIES IN THE SAME UY35743A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
UY0001035743A UY35743A (en) 2014-09-24 2014-09-24 SYNTHESIS PROCEDURE FOR THE PREPARATION OF C1-CETO MACROCICLIC ANALOGS OF HALICONDRINE B AND USEFUL INTERMEDIARIES IN THE SAME

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
UY0001035743A UY35743A (en) 2014-09-24 2014-09-24 SYNTHESIS PROCEDURE FOR THE PREPARATION OF C1-CETO MACROCICLIC ANALOGS OF HALICONDRINE B AND USEFUL INTERMEDIARIES IN THE SAME

Publications (1)

Publication Number Publication Date
UY35743A true UY35743A (en) 2016-04-29

Family

ID=56069597

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001035743A UY35743A (en) 2014-09-24 2014-09-24 SYNTHESIS PROCEDURE FOR THE PREPARATION OF C1-CETO MACROCICLIC ANALOGS OF HALICONDRINE B AND USEFUL INTERMEDIARIES IN THE SAME

Country Status (1)

Country Link
UY (1) UY35743A (en)
  • 2014

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Effective date: 20211207