UY33015A - PREPARATION OF GADOBUTROL THROUGH CERAMIC MEMBRANE - Google Patents

PREPARATION OF GADOBUTROL THROUGH CERAMIC MEMBRANE

Info

Publication number
UY33015A
UY33015A UY0001033015A UY33015A UY33015A UY 33015 A UY33015 A UY 33015A UY 0001033015 A UY0001033015 A UY 0001033015A UY 33015 A UY33015 A UY 33015A UY 33015 A UY33015 A UY 33015A
Authority
UY
Uruguay
Prior art keywords
gadobutrol
preparation
ceramic membrane
cyclodecan
dioxepan
Prior art date
Application number
UY0001033015A
Other languages
Spanish (es)
Inventor
Dr Johannes Platzek
Original Assignee
Bayer Schering Pharma
Aktienegekkchaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE200910053252 external-priority patent/DE102009053252B3/en
Priority claimed from DE200910057274 external-priority patent/DE102009057274B4/en
Application filed by Bayer Schering Pharma, Aktienegekkchaft filed Critical Bayer Schering Pharma
Publication of UY33015A publication Critical patent/UY33015A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Abstract

Se describe un nuevo procedimiento para la preparación de gadobutrol que proporciona el compuesto meta a partir de complejo de N-(6-hidroxi-2,2-dimetil-1,3-dioxepan-5-il)-1,4,7,10-tetraaza-ciclodecan-litio en un proceso en un recipiente, sin aislamiento intermedio y purificación intermedia, por medio de diálisis a través de membranas cerámicas con gran rendimiento y pureza.A new process for the preparation of gadobutrol which provides the target compound from N- (6-hydroxy-2,2-dimethyl-1,3-dioxepan-5-yl) -1,4,7 complex is described, 10-tetraaza-cyclodecan-lithium in a process in a container, without intermediate isolation and intermediate purification, by means of dialysis through ceramic membranes with great performance and purity.

UY0001033015A 2009-11-09 2010-11-08 PREPARATION OF GADOBUTROL THROUGH CERAMIC MEMBRANE UY33015A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200910053252 DE102009053252B3 (en) 2009-11-09 2009-11-09 Making gadobutrol, to diagnose stroke, comprises e.g. reacting N-(6-hydroxy-2,2-dimethyl-1,3-dioxepan-5-yl)-tetraaza-cyclododecane lithium chloride or bromide complex with haloacetic acid and lithium hydroxide or N-methyl imidazole
DE200910057274 DE102009057274B4 (en) 2009-12-02 2009-12-02 Gadobutrol preparation using trioxobicyclo-octane

Publications (1)

Publication Number Publication Date
UY33015A true UY33015A (en) 2011-06-30

Family

ID=43708819

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001033015A UY33015A (en) 2009-11-09 2010-11-08 PREPARATION OF GADOBUTROL THROUGH CERAMIC MEMBRANE

Country Status (4)

Country Link
AR (1) AR081271A1 (en)
TW (1) TW201139388A (en)
UY (1) UY33015A (en)
WO (1) WO2011054480A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009053171B4 (en) * 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Process for the preparation of the calcium complex of dihydroxy-hydroxy-methylpropyl-tetraazacyclododecane-triacetic acid (Calcobutrol)
RS60001B1 (en) 2011-04-21 2020-04-30 Bayer Ip Gmbh Preparation of high-purity gadobutrol
US10195295B2 (en) 2014-02-06 2019-02-05 T2Pharma Gmbh Process for purifying 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetraacetic acid
CN106187930B (en) * 2016-07-12 2018-10-19 嘉实（湖南）医药科技有限公司 The preparation method of high-purity calcobutrol
CN106543094A (en) * 2016-11-04 2017-03-29 嘉实（湖南）医药科技有限公司 The preparation method of high-purity gadobutrol
CN109293592A (en) * 2017-07-24 2019-02-01 天津科伦药物研究有限公司 A method of preparing Gadobutrol
CN113527223B (en) * 2021-06-22 2023-05-09 安徽普利药业有限公司 Refining method of gadobutrol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3625417C2 (en) 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecane derivatives
DE4009119A1 (en) 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-TETRAAZACYCLODODECANE-BUTYLTRIOLS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
US5447635A (en) 1991-02-26 1995-09-05 Bracco International B.V. Process of concentration and purification of organic compounds
DE19724186C2 (en) 1997-06-02 2002-07-18 Schering Ag Process for the mono- and 1,7-bis-N-ß-hydroxyalkylation of cycles and the corresponding N-ß-hydroxyalkyl-1,4,7,10-tetraazacyclododecane-Li salt complexes
IT1292128B1 (en) 1997-06-11 1999-01-25 Bracco Spa PROCESS FOR THE PREPARATION OF MACROCYCLIC CHELANTS AND THEIR CHELATES WITH PARAMAGNETIC METALLIC IONS
DE10064467C2 (en) * 2000-12-15 2002-10-31 Schering Ag Lithium complexes of N- (1-hydroxymethyl-2,3-dihydroxypropyl) -1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, their preparation and use
DE102004006048B4 (en) * 2004-02-02 2009-11-26 Axxonis Pharma Ag An intravenous injection or infusion solution containing a combination drug for use as a contrast enhancer in MR angiography

Also Published As

Publication number Publication date
TW201139388A (en) 2011-11-16
AR081271A1 (en) 2012-08-01
WO2011054480A1 (en) 2011-05-12

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20190521