UY32354A - COMPOSITION OF BIOCOMPATIBLE ALGINIC ACID MICROPARTICLES FOR RELEASE - Google Patents

COMPOSITION OF BIOCOMPATIBLE ALGINIC ACID MICROPARTICLES FOR RELEASE

Info

Publication number
UY32354A
UY32354A UY0001032354A UY32354A UY32354A UY 32354 A UY32354 A UY 32354A UY 0001032354 A UY0001032354 A UY 0001032354A UY 32354 A UY32354 A UY 32354A UY 32354 A UY32354 A UY 32354A
Authority
UY
Uruguay
Prior art keywords
microparticles
composition
biocompatible
alginic acid
release
Prior art date
Application number
UY0001032354A
Other languages
Spanish (es)
Inventor
Salvador Grancha Gamon
Anna Nardi Ricart
Josep Maria Sune Negre
Josep Ramon Tico Grau
Montserrat Minarro Carmona
Original Assignee
Grifols Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40793335&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY32354(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Grifols Sa filed Critical Grifols Sa
Publication of UY32354A publication Critical patent/UY32354A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Abstract

La presente invención se refiere a: -composición de micropartículas biocompatibles de ácido algínico o sus sales y un principio activo para la liberación controlada de principios activos por vía intravenosa. -particularmente a micropartículas para la encapsulación de un principio activo que va a ser administrado por vía intravenosa a un paciente que lo necesite. Dichas micropartículas que tienen una combinación de tamaño adecuada para lograr un incremento de la vida media o permanencia del principio activo en sangre, con una baja captación hepática y un rápido aclaramiento celular cuando son administradas por vía intravenosa.The present invention relates to: -composition of biocompatible microparticles of alginic acid or its salts and an active ingredient for the controlled release of active ingredients intravenously. -particularly to microparticles for the encapsulation of an active substance that will be administered intravenously to a patient in need. Said microparticles that have a combination of adequate size to achieve an increase in the half-life or permanence of the active substance in blood, with low hepatic uptake and rapid cellular clearance when administered intravenously.

UY0001032354A 2008-12-23 2009-12-22 COMPOSITION OF BIOCOMPATIBLE ALGINIC ACID MICROPARTICLES FOR RELEASE UY32354A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200803671A ES2319158B1 (en) 2008-12-23 2008-12-23 COMPOSITION OF BIOCOMPATIBLE ALGINIC ACID MICROPARTICLES FOR THE CONTROLLED RELEASE OF ACTIVE PRINCIPLES BY INTRAVENOUS VIA.

Publications (1)

Publication Number Publication Date
UY32354A true UY32354A (en) 2010-07-30

Family

ID=40793335

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032354A UY32354A (en) 2008-12-23 2009-12-22 COMPOSITION OF BIOCOMPATIBLE ALGINIC ACID MICROPARTICLES FOR RELEASE

Country Status (17)

Country Link
US (1) US7931916B2 (en)
EP (1) EP2201940B1 (en)
JP (2) JP5297994B2 (en)
CN (1) CN101757631B (en)
AR (1) AR074820A1 (en)
AU (1) AU2009248454B2 (en)
BR (1) BRPI0906284A2 (en)
CA (1) CA2688047C (en)
CL (1) CL2009002204A1 (en)
ES (2) ES2319158B1 (en)
HK (1) HK1141451A1 (en)
HU (1) HUE028485T2 (en)
MX (1) MX2009014178A (en)
NZ (1) NZ582166A (en)
PL (1) PL2201940T3 (en)
RU (1) RU2476235C2 (en)
UY (1) UY32354A (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102429862B (en) * 2011-11-29 2013-05-01 江苏德达医药科技有限公司 Sustained-release povidone iodine eye drops
RU2519158C1 (en) * 2013-03-28 2014-06-10 Федеральное государственное бюджетное учреждение "Саратовский научно-исследовательский институт травматологии и ортопедии" Министерства здравоохранения Российской Федерации (ФГБУ "СарНИИТО" Минздрава России) Biodegradable wound coating and method for preparing biodegradable wound coating
CN104888226A (en) * 2014-03-06 2015-09-09 中国科学院大连化学物理研究所 Protein and/or polypeptide substance preparation
EP3307247A1 (en) * 2015-06-10 2018-04-18 Evonik Röhm GmbH Process for preparing a powder comprising a human coagulation factor protein and a lactic acid polymer
US11464748B2 (en) 2016-02-01 2022-10-11 Emory University Particles for targeted delivery and uses in managing bleeding or blood clotting
US20190343871A1 (en) * 2017-01-31 2019-11-14 Georgia Tech Research Corporation Compositions and Methods for Inhibiting Shear Induced Platelet Accumulation

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US4518046A (en) 1982-06-21 1985-05-21 Deere & Company Multiple implement hitch and transport
WO1991009119A1 (en) * 1989-12-13 1991-06-27 Trancel Corporation Improved alginate microcapsules, methods of making and using same
US5334640A (en) 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
US5417982A (en) 1994-02-17 1995-05-23 Modi; Pankaj Controlled release of drugs or hormones in biodegradable polymer microspheres
RU2071765C1 (en) * 1994-07-14 1997-01-20 Российский научно-исследовательский институт гематологии и трансфузиологии Method of liposome preparation
US6565842B1 (en) * 1995-06-07 2003-05-20 American Bioscience, Inc. Crosslinkable polypeptide compositions
JP3765338B2 (en) * 1995-12-15 2006-04-12 武田薬品工業株式会社 Manufacturing method of sustained-release preparation for injection
US5792477A (en) * 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
JPH11130698A (en) 1997-10-31 1999-05-18 Freunt Ind Co Ltd Alginic acid polyvalent metal spherical particle aggregate, release-controlled preparation comprising slightly soluble medicine carried on the spherical particle aggregate and their production
US6458387B1 (en) 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
WO2003082229A1 (en) * 2002-03-29 2003-10-09 Shiseido Co., Ltd. Composite powder and cosmetic containing the same
CA2484965A1 (en) 2002-04-30 2003-11-13 Canadian Blood Services Encapsulated cells to elicit immune response
WO2006028996A2 (en) 2004-09-03 2006-03-16 Trustees Of Tufts College Emulsan-alginate microspheres and methods of use thereof
WO2006116546A1 (en) * 2005-04-27 2006-11-02 Baxter International Inc. Surface-modified microparticles and methods of forming and using the same
CN101312736B (en) 2005-10-21 2013-03-20 生命细胞产品有限公司 Encapsulation system
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WO2007109244A2 (en) 2006-03-21 2007-09-27 Morehouse School Of Medicine Novel nanoparticles for delivery of active agents
PT103476B (en) 2006-05-10 2008-09-19 Univ De Coimbra PRODUCTION AND INSULATION PROCESS OF POLYMERIC MICRO- AND NANOPARTICLES CONTAINING MACROMOLECULES OF HYDROFYLIC AND THERMOLIBLE NATURE
WO2008022146A2 (en) 2006-08-14 2008-02-21 Wayne State University Polymer-surfactant nanoparticles for sustained release of compounds
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Also Published As

Publication number Publication date
JP5698296B2 (en) 2015-04-08
PL2201940T3 (en) 2016-06-30
RU2476235C2 (en) 2013-02-27
HUE028485T2 (en) 2016-12-28
HK1141451A1 (en) 2010-11-12
ES2319158A1 (en) 2009-05-04
JP2013136636A (en) 2013-07-11
JP2010150257A (en) 2010-07-08
ES2563632T3 (en) 2016-03-15
JP5297994B2 (en) 2013-09-25
AU2009248454B2 (en) 2011-07-28
CN101757631B (en) 2013-02-27
MX2009014178A (en) 2010-06-30
RU2009147838A (en) 2011-06-27
CA2688047A1 (en) 2010-06-23
US20100159017A1 (en) 2010-06-24
ES2319158B1 (en) 2010-01-26
CN101757631A (en) 2010-06-30
EP2201940A1 (en) 2010-06-30
AU2009248454A1 (en) 2010-07-08
US7931916B2 (en) 2011-04-26
BRPI0906284A2 (en) 2013-07-30
AR074820A1 (en) 2011-02-16
CL2009002204A1 (en) 2010-05-07
CA2688047C (en) 2012-08-21
EP2201940B1 (en) 2016-02-24
NZ582166A (en) 2011-06-30

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RDES Application refused

Effective date: 20201223