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Application filed by Irm LlcfiledCriticalIrm Llc
Publication of UY32209ApublicationCriticalpatent/UY32209A/en
Medicines Containing Material From Animals Or Micro-Organisms
(AREA)
Abstract
La presente invención se refiere a compuestos y composiciones para expandir el número de células CD34+ para trasplante. La invención se refiere además a una población celular que comprende células madre hematopoiéticas (HSCs) expandidas, y a su uso en trasplante autólogo o alogénico para el tratamiento de los pacientes con enfermedades de inmunodeficiencia y autoinmunes heredadas y diversos trastornos hematopoiéticos, con el fin de reconstituir los linajes de células hematopoiéticas y las defensas del sistema inmunitario.The present invention relates to compounds and compositions for expanding the number of CD34 + cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs), and their use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficiency and autoimmune diseases and various hematopoietic disorders, in order to reconstitute hematopoietic cell lineages and immune system defenses.
UY32209A2008-08-062009-10-29
"COMPOUNDS THAT EXPAND HEMATOPOIETIC MOTHER CELLS"
UY32209A
(en)
Compounds derived from 5,7-substituted -imidazol [1,2-c] pyrimidines, jak kinase inhibitors; Preparation process; pharmaceutical composition; and its use to treat an autoimmune or inflammatory disease, the rejection of transplantation of organs, tissues or cells in a mammal.
"biological drug composition, methods of manipulating a live cell biological drug composition and providing live cell compositions at a treatment facility, as well as use of non-nutritive buffer formulated live cells"
Compounds derived from alkoxycarbonyl-amino-alkynyl-adenosine; pharmaceutical composition comprising them; use of the compound in the preparation of a useful medicine to treat autoimmune, inflammatory, allergic, infectious diseases among others.