UY29227A1 - SOLID PHARMACEUTICAL COMPOSITIONS THAT INCLUDE A COMBINATION OF DROSPIRENONE, ETHYNYLESTRADIOL AND AN APPROPRIATE SURFACTING AGENT THAT PRESENT A HOMOGENEITY OF CONTENT AND SPEED OF DISSOLUTION INSURED FOR NON-MICRONIZED DRUG - Google Patents
SOLID PHARMACEUTICAL COMPOSITIONS THAT INCLUDE A COMBINATION OF DROSPIRENONE, ETHYNYLESTRADIOL AND AN APPROPRIATE SURFACTING AGENT THAT PRESENT A HOMOGENEITY OF CONTENT AND SPEED OF DISSOLUTION INSURED FOR NON-MICRONIZED DRUGInfo
- Publication number
- UY29227A1 UY29227A1 UY29227A UY29227A UY29227A1 UY 29227 A1 UY29227 A1 UY 29227A1 UY 29227 A UY29227 A UY 29227A UY 29227 A UY29227 A UY 29227A UY 29227 A1 UY29227 A1 UY 29227A1
- Authority
- UY
- Uruguay
- Prior art keywords
- drospirenone
- dissolution
- pharmaceutical composition
- speed
- combination
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 5
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 title abstract 3
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 title abstract 3
- 229960004845 drospirenone Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 238000004090 dissolution Methods 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 229960002568 ethinylestradiol Drugs 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
- 239000002245 particle Substances 0.000 abstract 3
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 229940007690 drospirenone and ethinylestradiol Drugs 0.000 abstract 1
- 238000000265 homogenisation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000016087 ovulation Effects 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000008180 pharmaceutical surfactant Substances 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se relaciona con una composición farmacéutica asegurando una velocidad de disolución y homogenización de la droga no micronizada logrando una estabilidad físico-química inesperada.También con la composición farmacéutica obtenida por ese proceso y el uso de la composición farmacéutica para preparar un medicamento. La composición farmacéutica comprende, una combinación de dos principios activos, a saber drospirenona y etinilestradiol, un agente surfactante y excipientes farmacéuticamente aceptables con la condición de que la drospirenona presente la siguiente distribución: aproximadamente el 95% de ellos presenten un tamano de partícula inferior a 100 um (micrómetros), aproximadamente el 26 % presente un tamano de partícula inferior a 20 um (micrómetros) y aproximadamente el 15% presente un tamano de partícula inferior a 10.00 um (micrómetros), o con la condición de que dichos principios activos presenten una área superficial menos a 10000cm2/g o con la condición que la drospirenona no se encuentra en forma micronizada. Esta composición es usada para inhibir la ovulación y los cambios en la secreción cervical.The present invention relates to a pharmaceutical composition ensuring a speed of dissolution and homogenization of the non-micronized drug achieving an unexpected physical-chemical stability. Also with the pharmaceutical composition obtained by that process and the use of the pharmaceutical composition to prepare a medicament. The pharmaceutical composition comprises, a combination of two active ingredients, namely drospirenone and ethinyl estradiol, a pharmaceutically acceptable surfactant and excipients with the proviso that drospirenone has the following distribution: approximately 95% of them have a particle size of less than 100 um (micrometers), approximately 26% have a particle size of less than 20 um (micrometers) and approximately 15% have a particle size of less than 10.00 um (micrometers), or with the condition that said active substances have a surface area less than 10000cm2 / g with the condition that drospirenone is not in a micronized form. This composition is used to inhibit ovulation and changes in cervical secretion.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP040104928 AR047782A1 (en) | 2004-12-28 | 2004-12-28 | SOLID PHARMACEUTICAL COMPOSITIONS THAT INCLUDE A COMBINATION OF DROSPIRENONE, ETHYLYNESTRADIOL AND AN APPROPRIATE SURFACTING AGENT THAT PRESENTS A HOMOGENEITY OF CONTENT AND SPEED OF DISSOLVED INSURANCE FOR NON-MICRONIZED DRUG, PROCEDURE FOR PREPARATION OF USE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY29227A1 true UY29227A1 (en) | 2005-12-30 |
Family
ID=36607162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY29227A UY29227A1 (en) | 2004-12-28 | 2005-11-24 | SOLID PHARMACEUTICAL COMPOSITIONS THAT INCLUDE A COMBINATION OF DROSPIRENONE, ETHYNYLESTRADIOL AND AN APPROPRIATE SURFACTING AGENT THAT PRESENT A HOMOGENEITY OF CONTENT AND SPEED OF DISSOLUTION INSURED FOR NON-MICRONIZED DRUG |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR047782A1 (en) |
| CO (1) | CO5770093A1 (en) |
| PE (1) | PE20061112A1 (en) |
| UY (1) | UY29227A1 (en) |
-
2004
- 2004-12-28 AR ARP040104928 patent/AR047782A1/en unknown
-
2005
- 2005-11-24 UY UY29227A patent/UY29227A1/en not_active Application Discontinuation
- 2005-12-27 CO CO05130115A patent/CO5770093A1/en not_active Application Discontinuation
-
2006
- 2006-01-03 PE PE2006000018A patent/PE20061112A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CO5770093A1 (en) | 2007-06-29 |
| PE20061112A1 (en) | 2006-11-27 |
| AR047782A1 (en) | 2006-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20160726 |