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Publication of UY28842A1publicationCriticalpatent/UY28842A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Abstract
Se proporcionan compuestos tiadiazolidina de fórmula I donde R1 es un grupo orgánico que tiene al menos 8 átomos seleccionados de C u O, el cual no está enlazado directamente con el N a través de un -C(O)- y que comprende al menos un anillo aromático, y sus composiciones farmacéuticas. Estos compuestos son inhibidores de GSK-3 selectivos y han mejorado la biodisponibilidad. Son útiles para el tratamiento de enfermedades mediadas por GSK-3, estre otras Enfermedad de ALzheimer, Diabetes de tipo II, depresión y dano cerebral.Thiadiazolidine compounds of formula I are provided wherein R 1 is an organic group having at least 8 atoms selected from C or O, which is not directly linked to N through a -C (O) - and comprising at least one aromatic ring, and its pharmaceutical compositions. These compounds are selective GSK-3 inhibitors and have improved bioavailability. They are useful for the treatment of diseases mediated by GSK-3, including other Alzheimer's disease, type II diabetes, depression and brain damage.
COMPOUNDS DERIVED FROM CARBOXILIC ACIDS, ITS SALTS; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION, AND ITS USE IN THE TREATMENT OF DISEASES WHERE AN INHIBITOR OF THE FACTOR Xa AND / OR AN INHIBITOR OF SERINA PROTEASA IS NECESSARY.
A PIRAZOLPIRAZINE COMPOUND, PROCESS TO PREPARE IT, THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT AND ITS PREPARATION, AND THE USE OF THESE COMPOUNDS FOR THE PREPARATION OF MEDICINES.