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Application filed by Schering AgfiledCriticalSchering Ag
Priority to UY28668ApriorityCriticalpatent/UY28668A1/en
Publication of UY28668A1publicationCriticalpatent/UY28668A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Steroid Compounds
(AREA)
Abstract
Un parche que comprende una capa de droga con un bajo contenido de hormonas, como por ejemplo gestodeno, y opcionalmente un estrógeno (por ejemplo etinilestradiol). Al aplicar el parche a una mujer, se consiguen niveles en plasma de al menos 1.0ng/ml de gestodeno en condiciones de estado estacionario sin necesidad de indorporar potenciadores de penetración ni mejoradores de permeación en la capa que contiene droga. También son satisfactorios los niveles en plasma de las hormonas que se consiguen durante todo un período de al menos 1 semana, haciendo que el parche se pueda aplicar para utilizarlo en anticoncepción femenina con el concepto de aplicar el parche una vez a la semana.A patch comprising a layer of drug with a low content of hormones, such as, for example, signodene, and optionally an estrogen (for example ethinyl estradiol). By applying the patch to a woman, plasma levels of at least 1.0ng / ml of signodene are achieved under steady state conditions without the need to induce penetration enhancers or permeation enhancers in the drug-containing layer. Plasma levels of hormones that are achieved over a period of at least 1 week are also satisfactory, making the patch can be applied for use in female contraception with the concept of applying the patch once a week.
UY28668A2004-12-102004-12-10
TRANSDERMAL ADMINISTRATION HORMONES THAT DO NOT NEED PENETRATION POTENTIATORS
UY28668A1
(en)
USE OF ESTRADIOL VALERAT OR 17B-ESTRADIOL IN COMBINATION WITH DIENOGEST FOR ORAL TREATMENT TO MAINTAIN AND / OR INCREASE SEXUAL TREATMENT IN THE SPECIAL WOMAN
Pharmaceutical preparation for oral administration with controlled release of active ingredient in the small intestine comprising inert carriers, active ingredients, an inner layer composed of 2 diffusion layers to control the release and a gastro-resistant layer; Preparation method.