UY28575A1 - SOLID PHARMACEUTICAL COMPOSITIONS INCLUDING ACID BIS (E) -7- (4- (4-FLUORPHENYL-6-ISOPROPIL-2- (METHYL (METILSULFONYL) AMINO) PIRIMIDIN- 5-IL) -3R, 5S) -3.5 - DIHYDROXO- ............ - Google Patents

SOLID PHARMACEUTICAL COMPOSITIONS INCLUDING ACID BIS (E) -7- (4- (4-FLUORPHENYL-6-ISOPROPIL-2- (METHYL (METILSULFONYL) AMINO) PIRIMIDIN- 5-IL) -3R, 5S) -3.5 - DIHYDROXO- ............

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Publication number
UY28575A1
UY28575A1 UY28575A UY28575A UY28575A1 UY 28575 A1 UY28575 A1 UY 28575A1 UY 28575 A UY28575 A UY 28575A UY 28575 A UY28575 A UY 28575A UY 28575 A1 UY28575 A1 UY 28575A1
Authority
UY
Uruguay
Prior art keywords
amino
methyl
metilsulfonyl
dihydroxo
isopropil
Prior art date
Application number
UY28575A
Other languages
Spanish (es)
Inventor
Daniel Zanetti
Maria Eugenia Belgiorno
Original Assignee
Gador S A Ar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gador S A Ar filed Critical Gador S A Ar
Priority to UY28575A priority Critical patent/UY28575A1/en
Publication of UY28575A1 publication Critical patent/UY28575A1/en

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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Una composición farmacéutica caracterizada porque comprende el ácido bis (E) -7-(4-(4-fluorofenil)-6isopropil-2-(metil(metilsulfonil)amino)pirimidin -5-il)-(3R,5S)-3,5-dihidroxihept-6-enoico o la sal farmacéuticamente aceptable de este,como ingrediente o principio activo, un agente surfactante y excipientes farmacéuticamente aceptables. La presente formulación aumente la estabilidad físico-química de un inhibidor de la HMGCoA reductasa y también aumenta de la solubilidad "in Vitro" en medio fisiológicos líquidos artificiales a pH: 1.5, 4.5 y 7.0. También el precedimiento para obtenerlo, la composición farmacéutica obtenida por dicho proceso y el uso de la composición farmacéutica para preparar un medicamento.A pharmaceutical composition characterized in that it comprises bis (E) -7- (4- (4-fluorophenyl) -6isopropyl-2- (methyl (methylsulfonyl) amino) pyrimidin -5-yl) - (3R, 5S) -3, 5-dihydroxyhept-6-enoic or the pharmaceutically acceptable salt thereof, as an active ingredient or principle, a pharmaceutically acceptable surfactant and excipients. The present formulation increases the physical-chemical stability of an HMGCoA reductase inhibitor and also increases the solubility "in Vitro" in artificial liquid physiological media at pH: 1.5, 4.5 and 7.0. Also the precedent for obtaining it, the pharmaceutical composition obtained by said process and the use of the pharmaceutical composition to prepare a medicament.

UY28575A 2004-10-22 2004-10-22 SOLID PHARMACEUTICAL COMPOSITIONS INCLUDING ACID BIS (E) -7- (4- (4-FLUORPHENYL-6-ISOPROPIL-2- (METHYL (METILSULFONYL) AMINO) PIRIMIDIN- 5-IL) -3R, 5S) -3.5 - DIHYDROXO- ............ UY28575A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
UY28575A UY28575A1 (en) 2004-10-22 2004-10-22 SOLID PHARMACEUTICAL COMPOSITIONS INCLUDING ACID BIS (E) -7- (4- (4-FLUORPHENYL-6-ISOPROPIL-2- (METHYL (METILSULFONYL) AMINO) PIRIMIDIN- 5-IL) -3R, 5S) -3.5 - DIHYDROXO- ............

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
UY28575A UY28575A1 (en) 2004-10-22 2004-10-22 SOLID PHARMACEUTICAL COMPOSITIONS INCLUDING ACID BIS (E) -7- (4- (4-FLUORPHENYL-6-ISOPROPIL-2- (METHYL (METILSULFONYL) AMINO) PIRIMIDIN- 5-IL) -3R, 5S) -3.5 - DIHYDROXO- ............

Publications (1)

Publication Number Publication Date
UY28575A1 true UY28575A1 (en) 2004-11-30

Family

ID=38812979

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28575A UY28575A1 (en) 2004-10-22 2004-10-22 SOLID PHARMACEUTICAL COMPOSITIONS INCLUDING ACID BIS (E) -7- (4- (4-FLUORPHENYL-6-ISOPROPIL-2- (METHYL (METILSULFONYL) AMINO) PIRIMIDIN- 5-IL) -3R, 5S) -3.5 - DIHYDROXO- ............

Country Status (1)

Country Link
UY (1) UY28575A1 (en)

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Effective date: 20170516