UY28575A1 - SOLID PHARMACEUTICAL COMPOSITIONS INCLUDING ACID BIS (E) -7- (4- (4-FLUORPHENYL-6-ISOPROPIL-2- (METHYL (METILSULFONYL) AMINO) PIRIMIDIN- 5-IL) -3R, 5S) -3.5 - DIHYDROXO- ............ - Google Patents
SOLID PHARMACEUTICAL COMPOSITIONS INCLUDING ACID BIS (E) -7- (4- (4-FLUORPHENYL-6-ISOPROPIL-2- (METHYL (METILSULFONYL) AMINO) PIRIMIDIN- 5-IL) -3R, 5S) -3.5 - DIHYDROXO- ............Info
- Publication number
- UY28575A1 UY28575A1 UY28575A UY28575A UY28575A1 UY 28575 A1 UY28575 A1 UY 28575A1 UY 28575 A UY28575 A UY 28575A UY 28575 A UY28575 A UY 28575A UY 28575 A1 UY28575 A1 UY 28575A1
- Authority
- UY
- Uruguay
- Prior art keywords
- amino
- methyl
- metilsulfonyl
- dihydroxo
- isopropil
- Prior art date
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Una composición farmacéutica caracterizada porque comprende el ácido bis (E) -7-(4-(4-fluorofenil)-6isopropil-2-(metil(metilsulfonil)amino)pirimidin -5-il)-(3R,5S)-3,5-dihidroxihept-6-enoico o la sal farmacéuticamente aceptable de este,como ingrediente o principio activo, un agente surfactante y excipientes farmacéuticamente aceptables. La presente formulación aumente la estabilidad físico-química de un inhibidor de la HMGCoA reductasa y también aumenta de la solubilidad "in Vitro" en medio fisiológicos líquidos artificiales a pH: 1.5, 4.5 y 7.0. También el precedimiento para obtenerlo, la composición farmacéutica obtenida por dicho proceso y el uso de la composición farmacéutica para preparar un medicamento.A pharmaceutical composition characterized in that it comprises bis (E) -7- (4- (4-fluorophenyl) -6isopropyl-2- (methyl (methylsulfonyl) amino) pyrimidin -5-yl) - (3R, 5S) -3, 5-dihydroxyhept-6-enoic or the pharmaceutically acceptable salt thereof, as an active ingredient or principle, a pharmaceutically acceptable surfactant and excipients. The present formulation increases the physical-chemical stability of an HMGCoA reductase inhibitor and also increases the solubility "in Vitro" in artificial liquid physiological media at pH: 1.5, 4.5 and 7.0. Also the precedent for obtaining it, the pharmaceutical composition obtained by said process and the use of the pharmaceutical composition to prepare a medicament.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UY28575A UY28575A1 (en) | 2004-10-22 | 2004-10-22 | SOLID PHARMACEUTICAL COMPOSITIONS INCLUDING ACID BIS (E) -7- (4- (4-FLUORPHENYL-6-ISOPROPIL-2- (METHYL (METILSULFONYL) AMINO) PIRIMIDIN- 5-IL) -3R, 5S) -3.5 - DIHYDROXO- ............ |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UY28575A UY28575A1 (en) | 2004-10-22 | 2004-10-22 | SOLID PHARMACEUTICAL COMPOSITIONS INCLUDING ACID BIS (E) -7- (4- (4-FLUORPHENYL-6-ISOPROPIL-2- (METHYL (METILSULFONYL) AMINO) PIRIMIDIN- 5-IL) -3R, 5S) -3.5 - DIHYDROXO- ............ |
Publications (1)
Publication Number | Publication Date |
---|---|
UY28575A1 true UY28575A1 (en) | 2004-11-30 |
Family
ID=38812979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY28575A UY28575A1 (en) | 2004-10-22 | 2004-10-22 | SOLID PHARMACEUTICAL COMPOSITIONS INCLUDING ACID BIS (E) -7- (4- (4-FLUORPHENYL-6-ISOPROPIL-2- (METHYL (METILSULFONYL) AMINO) PIRIMIDIN- 5-IL) -3R, 5S) -3.5 - DIHYDROXO- ............ |
Country Status (1)
Country | Link |
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UY (1) | UY28575A1 (en) |
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2004
- 2004-10-22 UY UY28575A patent/UY28575A1/en not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20170516 |