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Application filed by Pfizer Prod IncfiledCriticalPfizer Prod Inc
Priority to UY28131ApriorityCriticalpatent/UY28131A1/en
Publication of UY28131A1publicationCriticalpatent/UY28131A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
La invención se refiere a compuestos de fórmula 1 y a sales, pro fármacos y solvatos farmacéuticamente aceptables de los mismos, en la que R1, R2, R3 y R5 son como se definen en la presente memoria, y en la que el compuesto de fórmula 1 comprende opcionalmente además un sustituyente hidroxi o un ácido O-glucurónico. La invención se refiere también a procedimientos de tratamiento del crecimiento celular anormal en mamíferos mediante la administración de los compuesto de fórmula 1 y a composiciones farmacéuticas para tratar dichos trastornos que contienen los compuestos de fórmula 1. La invención se refiere también a procedimientos de preparación de los compuestos de fórmula 1.The invention relates to compounds of formula 1 and pharmaceutically acceptable salts, pro drugs and solvates thereof, wherein R1, R2, R3 and R5 are as defined herein, and in which the compound of formula 1 optionally further comprises a hydroxy substituent or an O-glucuronic acid. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and pharmaceutical compositions for treating such disorders containing the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
UY28131A2003-12-172003-12-17
BICYCLE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELLULAR GROWTH
UY28131A1
(en)
COMPOUNDS DERIVED FROM QUINOLIN-2-ONA- SUBSTITUTED WITH HETEROARILO USEFUL AS ANTI-VANEER AGENTS, PROCESSING PROCESSING OF DISEASES USING SUCH COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING IT
NOVEL 1,4-BENZOTHIEPIN-l,1-DIOXIDE DERIVATIVES WHICH ARE SUBSTITUTED WITH BENZYL GROUPS, METHOD FOR PRODUCING DRUGS CONTAINING SAID COMPOUNDS AND USE THEREOF
BENZONE-CONDENSED HETEROARILAMIDE TYENOPIRIDIN DERIVATIVES USED AS THERAPEUTIC AGENTS, PHARMACEUTICAL COMPOSITIONS, INCLUDING THEM, AND THEIR APPLICATION
EUROTINONA AND DERIVATIVES OF THE SAME, PROCEDURE FOR THEIR PREPARATION, A MICROORGANISM, PHARMACEUTICAL COMPOSITIONS, PROCEDURE FOR THEIR PRODUCTION, THE USE OF SUCH DERIVATIVES AND COMPOSITIONS FOR THE PREPARATION OF DRUGS, AND USE OF SUCH MICROORGANISM
DERIVATIVES OF QUINOLINA, PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND AND THE USE OF SUCH IN THE TREATMENT OF CENTRAL AND PERIPHERAL NERVOUS SYSTEM DISEASES