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Application filed by Hoffmann La RochefiledCriticalHoffmann La Roche
Priority to UY26619ApriorityCriticalpatent/UY26619A1/en
Publication of UY26619A1publicationCriticalpatent/UY26619A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
La invención se refiere a compuestos que generalmente son antagonistas del receptor IP y los cuales están representados por la fórmula I, en donde R1, R2 y R3 son cada uno de ellos, independiente de cada caso, arilo o heteroarilo, R4 es -COOH o tetrazolilo, A, B, m, n, y r son como se ha definido en la especificación; o isómeros individuales, mezclas de isómeros racémicas o no racémicas, o sales farmacéuticamente aceptables o solvatos de los mismos. La invención se refiere además a composiciones farmacéuticas que contienen dichos compuestos, procedimientos para su preparación y su empleo como agentes terapéuticos.The invention relates to compounds that are generally IP receptor antagonists and which are represented by formula I, where R1, R2 and R3 are each, independently of each case, aryl or heteroaryl, R4 is -COOH or tetrazolyl, A, B, m, n, and r are as defined in the specification; or individual isomers, mixtures of racemic or non-racemic isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their preparation and their use as therapeutic agents.
UY26619A2001-03-152001-03-15
DERIVATIVES OF CARBOXYLIC ACID AS IP ANTAGONISTS
UY26619A1
(en)
DERIVATIVES OF BENZOCONDENSED HETEROARILAMIDE OF USEFUL TIENOPIRIDINS AS THERAPEUTIC AGENTS, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THE SAME AND METHODS FOR USE