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Priority claimed from EP98107925Aexternal-prioritypatent/EP0953639A1/en
Application filed by Boehringer Ingelheim IntfiledCriticalBoehringer Ingelheim Int
Publication of UY25549A1publicationCriticalpatent/UY25549A1/en
Preparation Of Compounds By Using Micro-Organisms
(AREA)
Peptides Or Proteins
(AREA)
Abstract
Se proporciona un método para preparar proteína de anticuerpos recombinantes que fijan específicamente proteína de activación de fibroblastos alfa (FAP-alfa) y que comprenden modificaciones en el marco que dan como resultado una productividad mejorada en células hospedantes. La invención se refiere también al uso de dichos anticuerpos para fines de diagnóstico y terapéuticos en el tratamiento de cánceres epiteliales, y a métodos para producir dichos anticuerpos.A method is provided for preparing recombinant antibody protein that specifically binds fibroblast activating protein alpha (FAP-alpha) and comprises framework modifications that result in improved productivity in host cells. The invention also relates to the use of said antibodies for diagnostic and therapeutic purposes in the treatment of epithelial cancers, and to methods for producing said antibodies.
UY25549A1998-04-301999-06-08
METHOD TO PRODUCE A SPECIFIC ANTIBODY OF FAP-ALFA WITH IMPROVED PRODUCTIVITY.
UY25549A1
(en)
Polypeptides capable of forming antigen binding structures with specificity for the rhesus antigens in the dna that encodes them and the process for their preparation and use
Defective recombinant adenoviruses pharmaceutical composition use of adenovirus composition and preparation process for specific cytotoxic t cells of a tumor antigen
AN OB MUTEIN, A DNA SEQUENCE, A VECTOR OF EXPRESSION A PROCARIOT OR MAMMAL HOSPITAL CELL, A RECOMBINANT BACULOVIRUS, A CELL PHONE, A METHOD FOR THE PRODUCTION OF AN OB MUTEIN, A PHARMACEUTICAL COMPOSITION, THE USE PREPARATION OF A COMPOSI