UY25549A1 - METHOD TO PRODUCE A SPECIFIC ANTIBODY OF FAP-ALFA WITH IMPROVED PRODUCTIVITY. - Google Patents

METHOD TO PRODUCE A SPECIFIC ANTIBODY OF FAP-ALFA WITH IMPROVED PRODUCTIVITY.

Info

Publication number
UY25549A1
UY25549A1 UY25549A UY25549A UY25549A1 UY 25549 A1 UY25549 A1 UY 25549A1 UY 25549 A UY25549 A UY 25549A UY 25549 A UY25549 A UY 25549A UY 25549 A1 UY25549 A1 UY 25549A1
Authority
UY
Uruguay
Prior art keywords
fap
improved productivity
alfa
produce
specific antibody
Prior art date
Application number
UY25549A
Other languages
Spanish (es)
Inventor
John Edward Park
Pilar Garin-Chesa
Uwe Bamberger
Wolfgang J Rettig
Olivier Léger
Jose Saldanha
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP98107925A external-priority patent/EP0953639A1/en
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of UY25549A1 publication Critical patent/UY25549A1/en

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se proporciona un método para preparar proteína de anticuerpos recombinantes que fijan específicamente proteína de activación de fibroblastos alfa (FAP-alfa) y que comprenden modificaciones en el marco que dan como resultado una productividad mejorada en células hospedantes. La invención se refiere también al uso de dichos anticuerpos para fines de diagnóstico y terapéuticos en el tratamiento de cánceres epiteliales, y a métodos para producir dichos anticuerpos.A method is provided for preparing recombinant antibody protein that specifically binds fibroblast activating protein alpha (FAP-alpha) and comprises framework modifications that result in improved productivity in host cells. The invention also relates to the use of said antibodies for diagnostic and therapeutic purposes in the treatment of epithelial cancers, and to methods for producing said antibodies.

UY25549A 1998-04-30 1999-06-08 METHOD TO PRODUCE A SPECIFIC ANTIBODY OF FAP-ALFA WITH IMPROVED PRODUCTIVITY. UY25549A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98107925A EP0953639A1 (en) 1998-04-30 1998-04-30 FAPalpha-specific antibody with improved producibility
UY25493 1999-04-30

Publications (1)

Publication Number Publication Date
UY25549A1 true UY25549A1 (en) 1999-11-17

Family

ID=71093366

Family Applications (1)

Application Number Title Priority Date Filing Date
UY25549A UY25549A1 (en) 1998-04-30 1999-06-08 METHOD TO PRODUCE A SPECIFIC ANTIBODY OF FAP-ALFA WITH IMPROVED PRODUCTIVITY.

Country Status (1)

Country Link
UY (1) UY25549A1 (en)

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20110808