UY25369A1 - PROCEDURE FOR PREPARING PROTEASE INHIBITORS - Google Patents
PROCEDURE FOR PREPARING PROTEASE INHIBITORSInfo
- Publication number
- UY25369A1 UY25369A1 UY25369A UY25369A UY25369A1 UY 25369 A1 UY25369 A1 UY 25369A1 UY 25369 A UY25369 A UY 25369A UY 25369 A UY25369 A UY 25369A UY 25369 A1 UY25369 A1 UY 25369A1
- Authority
- UY
- Uruguay
- Prior art keywords
- alkyl
- het
- procedure
- protease inhibitors
- alkenyl
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un procedimiento para preparar compuestos derivados de pirrolidina (ver formula l en solicitud), en la que Y es Ar o NR1R2; R3 es H, alquenilo, alquinilo, Het, Ar, o alquilo opcionalmente sustituido con OR', SR', NR'2, N(C=NH)NH2, R4 es H, alquilo, alquenilo, Ar-alquilo, o Het-alquilo; R5 es Ar-alquilo, Het-alquilo, adamantil-C(O)-, Ar-C(O), etc; N es 1, 2, o 3; R''' es H, alquilo, cicloalquil-alquilo, Ar-alquilo o Het-alquilo; o una sal farmacéuticamente aceptable de losmismos; que son inhibidores de proteasas de cisteína , en particular de la catepsina K, Y son útiles en el tratamiento de enfermedades en las que la inhibición de la pérdidad ósea es un factor.A process for preparing compounds derived from pyrrolidine (see formula 1 in application), wherein Y is Ar or NR1R2; R3 is H, alkenyl, alkynyl, Het, Ar, or alkyl optionally substituted with OR ', SR', NR'2, N (C = NH) NH2, R4 is H, alkyl, alkenyl, Ar-alkyl, or Het- I rent; R5 is Ar-alkyl, Het-alkyl, adamantyl-C (O) -, Ar-C (O), etc; N is 1, 2, or 3; R '' 'is H, alkyl, cycloalkyl-alkyl, Ar-alkyl or Het-alkyl; or a pharmaceutically acceptable salt thereof; which are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4686597P | 1997-05-08 | 1997-05-08 | |
| UY24991 | 1998-05-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY25369A1 true UY25369A1 (en) | 1999-11-17 |
Family
ID=71093377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25369A UY25369A1 (en) | 1997-05-08 | 1999-01-25 | PROCEDURE FOR PREPARING PROTEASE INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| UY (1) | UY25369A1 (en) |
-
1999
- 1999-01-25 UY UY25369A patent/UY25369A1/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RDES | Application refused |
Effective date: 20010525 |