UY24181A1 - METHOD TO TREAT AN ACUTE MYOCARDIAL INFARCTION WITH HIRUDIN AND ACETYLSALICYLIC ACID IN PATIENTS NOT UNDER THROMBOLYTIC TREATMENT - Google Patents

METHOD TO TREAT AN ACUTE MYOCARDIAL INFARCTION WITH HIRUDIN AND ACETYLSALICYLIC ACID IN PATIENTS NOT UNDER THROMBOLYTIC TREATMENT

Info

Publication number
UY24181A1
UY24181A1 UY24181A UY24181A UY24181A1 UY 24181 A1 UY24181 A1 UY 24181A1 UY 24181 A UY24181 A UY 24181A UY 24181 A UY24181 A UY 24181A UY 24181 A1 UY24181 A1 UY 24181A1
Authority
UY
Uruguay
Prior art keywords
hirudin
patients
treat
under
myocardial infarction
Prior art date
Application number
UY24181A
Other languages
Spanish (es)
Inventor
Hubert Dr Heinrichs
Charles H Hennekens
Original Assignee
Behringwerke Ag Y Brigham And Womens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke Ag Y Brigham And Womens Hospital filed Critical Behringwerke Ag Y Brigham And Womens Hospital
Publication of UY24181A1 publication Critical patent/UY24181A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

Procedimiento para preparar una combinación farmacéutica que comprende una combinación de hirudina y ASA, caracterizada porque es sinérgica y aplicable al tratamiento de sucesos miocárdios o cardiovasculares. Dicha composición adicionalmente comprende uno o más vehículos farmacológicamente aceptables y no contiene ningún tipo de agente antitrombótico. En particular se incluye un procedimiento según lo descrito donde la hirudina se selecciona del grupo que consta de: hinudina de la variante HV1, hitudina de la variante HV2, y hirudina de la variante PA.Process for preparing a pharmaceutical combination comprising a combination of hirudin and ASA, characterized in that it is synergistic and applicable to the treatment of myocardial or cardiovascular events. Said composition additionally comprises one or more pharmacologically acceptable carriers and does not contain any type of antithrombotic agent. In particular a method is included as described where hirudin is selected from the group consisting of: HV1 variant hinudin, HV2 variant hitudin, and PA variant hirudin.

UY24181A 1995-03-15 1996-03-15 METHOD TO TREAT AN ACUTE MYOCARDIAL INFARCTION WITH HIRUDIN AND ACETYLSALICYLIC ACID IN PATIENTS NOT UNDER THROMBOLYTIC TREATMENT UY24181A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40526995A 1995-03-15 1995-03-15
US44055695A 1995-05-12 1995-05-12

Publications (1)

Publication Number Publication Date
UY24181A1 true UY24181A1 (en) 1996-03-20

Family

ID=27019016

Family Applications (1)

Application Number Title Priority Date Filing Date
UY24181A UY24181A1 (en) 1995-03-15 1996-03-15 METHOD TO TREAT AN ACUTE MYOCARDIAL INFARCTION WITH HIRUDIN AND ACETYLSALICYLIC ACID IN PATIENTS NOT UNDER THROMBOLYTIC TREATMENT

Country Status (14)

Country Link
EP (1) EP0732102A3 (en)
JP (1) JPH0920681A (en)
KR (1) KR960033468A (en)
CN (1) CN1141809A (en)
AR (1) AR002968A1 (en)
AU (1) AU711660B2 (en)
BR (1) BR9601024A (en)
CA (1) CA2171509A1 (en)
FI (1) FI961171A (en)
IL (1) IL117485A0 (en)
NO (1) NO961046L (en)
NZ (1) NZ286082A (en)
SG (1) SG43242A1 (en)
UY (1) UY24181A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004262776A (en) * 2003-02-21 2004-09-24 Teikoku Seiyaku Co Ltd Angiogenic promoter
JP4855073B2 (en) * 2003-09-19 2012-01-18 キッセイ薬品工業株式会社 Concomitant medication
US20060222640A1 (en) * 2005-03-29 2006-10-05 Boehringer Ingelheim International Gmbh New pharmaceutical compositions for treatment of thrombosis
WO2008009638A2 (en) * 2006-07-17 2008-01-24 Boehringer Ingelheim International Gmbh New indications for direct thrombin inhibitors in the cardiovascular field

Also Published As

Publication number Publication date
AU4807296A (en) 1996-09-26
NZ286082A (en) 1998-09-24
IL117485A0 (en) 1996-07-23
JPH0920681A (en) 1997-01-21
FI961171A0 (en) 1996-03-13
NO961046D0 (en) 1996-03-14
EP0732102A3 (en) 1999-01-27
CN1141809A (en) 1997-02-05
AR002968A1 (en) 1998-05-27
CA2171509A1 (en) 1996-09-16
AU711660B2 (en) 1999-10-21
BR9601024A (en) 1997-12-30
EP0732102A2 (en) 1996-09-18
NO961046L (en) 1996-09-16
FI961171A (en) 1996-09-16
KR960033468A (en) 1996-10-22
SG43242A1 (en) 1997-10-17

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