UY23774A1 - PROCEDURE FOR THE PREPARATION OF SUBSTITUTED PYRROLES - Google Patents
PROCEDURE FOR THE PREPARATION OF SUBSTITUTED PYRROLESInfo
- Publication number
- UY23774A1 UY23774A1 UY23774A UY23774A UY23774A1 UY 23774 A1 UY23774 A1 UY 23774A1 UY 23774 A UY23774 A UY 23774A UY 23774 A UY23774 A UY 23774A UY 23774 A1 UY23774 A1 UY 23774A1
- Authority
- UY
- Uruguay
- Prior art keywords
- formula
- preparation
- compound
- compounds
- procedure
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se describe un procedimiento para la preparación de compuestos de la fórmula general I (figura 1) en donde R1 representa arilo, entre otras posibilidades, así como las sales farmaceuticamente aceptables de compuestos acídicos de fórmula I con bases y de compuestos básicos de fórmula I con ácidos, cuyo procedimiento comprende disociar el grupo protector designado por R3 de un compuesto de fórmula general II (figura 2), y, si se desea, modificar funcionalmente un sustituyente reactivo presente en R2 en un compuesto de fórmula I obtenido. Se prepara un compuesto elegido de, por ejemplo: 3-[8(R o S)-1(R o S)-aminoetil]-6,7,8,9-tetrahidropirido[1,2-a]-indol-10-il]-4-(1-metil-3-indolil)-1H-pirrol-2,5-diona. El medicamento preparado es un antiinflamatorio, inunológico, oncológico, broncopulmonar, dermatológico o cardiovascular, entre otros.A process is described for the preparation of compounds of the general formula I (figure 1) in which R1 represents aryl, among other possibilities, as well as the pharmaceutically acceptable salts of acidic compounds of formula I with bases and of basic compounds of formula I with acids, the process of which comprises dissociating the protecting group designated by R3 from a compound of general formula II (figure 2), and, if desired, functionally modifying a reactive substituent present in R2 in a compound of formula I obtained. A compound selected from, for example, is prepared: 3- [8 (R or S) -1 (R or S) -aminoethyl] -6,7,8,9-tetrahydropyrido [1,2-a] -indole-10 -yl] -4- (1-methyl-3-indolyl) -1H-pyrrole-2,5-dione. The drug prepared is an anti-inflammatory, immunological, oncological, bronchopulmonary, dermatological or cardiovascular, among others.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939309602A GB9309602D0 (en) | 1993-05-10 | 1993-05-10 | Substituted pyrroles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY23774A1 true UY23774A1 (en) | 1994-11-09 |
Family
ID=10735215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY23774A UY23774A1 (en) | 1993-05-10 | 1994-05-09 | PROCEDURE FOR THE PREPARATION OF SUBSTITUTED PYRROLES |
Country Status (8)
| Country | Link |
|---|---|
| KR (1) | KR100331515B1 (en) |
| GB (2) | GB9309602D0 (en) |
| PL (1) | PL177216B1 (en) |
| RO (1) | RO115629B1 (en) |
| SV (1) | SV1994000023A (en) |
| TW (1) | TW248561B (en) |
| UY (1) | UY23774A1 (en) |
| YU (1) | YU19194A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL2017296A (en) | 2015-08-12 | 2017-02-16 | Asml Netherlands Bv | Methods for controlling lithographic apparatus, lithographic apparatus and device manufacturing method |
-
1993
- 1993-05-10 GB GB939309602A patent/GB9309602D0/en active Pending
-
1994
- 1994-02-21 GB GB9403249A patent/GB9403249D0/en active Pending
- 1994-04-13 YU YU19194A patent/YU19194A/en unknown
- 1994-04-19 TW TW83103453A patent/TW248561B/zh active
- 1994-05-09 PL PL94303368A patent/PL177216B1/en unknown
- 1994-05-09 SV SV1994000023A patent/SV1994000023A/en not_active Application Discontinuation
- 1994-05-09 KR KR1019940010048A patent/KR100331515B1/en not_active IP Right Cessation
- 1994-05-09 UY UY23774A patent/UY23774A1/en unknown
- 1994-05-13 RO RO94-00798A patent/RO115629B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU19194A (en) | 1997-03-07 |
| SV1994000023A (en) | 1995-06-09 |
| KR100331515B1 (en) | 2002-08-19 |
| GB9309602D0 (en) | 1993-06-23 |
| RO115629B1 (en) | 2000-04-28 |
| PL177216B1 (en) | 1999-10-29 |
| TW248561B (en) | 1995-06-01 |
| GB9403249D0 (en) | 1994-04-13 |
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