USRE47614E1 - Drug delivery device and method of manufacturing a drug delivery device - Google Patents

Drug delivery device and method of manufacturing a drug delivery device Download PDF

Info

Publication number
USRE47614E1
USRE47614E1 US14/934,406 US200914934406A USRE47614E US RE47614 E1 USRE47614 E1 US RE47614E1 US 200914934406 A US200914934406 A US 200914934406A US RE47614 E USRE47614 E US RE47614E
Authority
US
United States
Prior art keywords
cartridge
spring washer
housing
delivery device
drug delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
US14/934,406
Inventor
Michael Harms
Steffen RAAB
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Sanofi Aventis Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority claimed from EP08017889 external-priority
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40513417&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=USRE47614(E1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Priority to US14/934,406 priority Critical patent/USRE47614E1/en
Assigned to SANOFI-AVENTIS DEUTSCHLAND GMBH reassignment SANOFI-AVENTIS DEUTSCHLAND GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HARMS, MICHAEL, RAAB, STEFFEN
Application granted granted Critical
Publication of USRE47614E1 publication Critical patent/USRE47614E1/en
Active legal-status Critical Current
Adjusted expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2477—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means to reduce play of ampoule within ampoule holder, e.g. springs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe
    • A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • A61M5/31595—Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining
    • Y10T29/49863—Assembling or joining with prestressing of part

Abstract

The present invention relates to drug delivery device and a and method of manufacturing a drug delivery device with a housing having a proximal end and a distal end, a cartridge adapted to accommodate a drug, a cartridge retaining member adapted to retain the cartridge, the cartridge retaining member being secured to the housing, and a spring washer being arranged within the housing so as to exerting a force on the cartridge and securing the cartridge against movement with respect to the cartridge retaining member and against movement with respect to the housing.

Description

CROSS REFERENCE TO RELATED APPLICATIONS
The present application is a U.S. National Phase Application pursuant to 35 U.S.C. § 371 of International Application No. PCT/EP2009/063075 filed Oct. 8, 2009, which claims priority to European Patent Application No. 08017889.0 filed on Oct. 13, 2008. The entire disclosure content of these applications are herewith incorporated by reference into the present application.
TECHNICAL FIELD
The present invention relates to a drug delivery device and a method of manufacturing a drug delivery device. Drug delivery devices are used for the administration of a drug, for example insulin, heparin or growth hormones. Some devices are configured to deliver a plurality of doses. Additionally some devices are configured to allow setting of different dose sizes which are to be delivered. Here it is important that the size of the dose can be precisely set and the set dose can be reliably delivered.
BACKGROUND
In US 2007/0021718 A1 a syringe is shown having a spring which is arranged between a housing insert and a driving element. The spring may serve as compensation for longitudinal tolerances in order to support a medical container in an injection device.
In U.S. Pat. No. 3,742,948 a syringe is shown having a pressure member constructed as a cup spring. The pressure member includes resilient lugs which bear on the upper edge of the liquid container with their free end.
Further medication delivery devices are known from the documents WO 2005/032449 A1 and DE 10 2004 053529 A1.
It is an aim of the present invention to provide for an improved drug delivery device. In particular, a drug delivery device should be provided, which allows for improved operability with respect to dosage control and/or improved reproducibility of the dosage in connection with different cartridges.
SUMMARY
For this aim, a drug delivery device comprises a housing with a proximal end and a distal end, a cartridge adapted to accommodate a drug, a cartridge retaining member adapted to retain the cartridge, the cartridge retaining member being secured to the housing, and a spring washer being arranged within the housing so as to exert a force on the cartridge and secure the cartridge against movement with respect to the cartridge retaining member and, preferably, against movement with respect to the housing.
In a drug delivery device of this kind movement of the cartridge with respect to the housing and/or the cartridge retaining member is reduced or even avoided on account of the spring washer, which exerts the force on the cartridge. The spring washer can reduce play between cartridge and housing and/or between cartridge and cartridge retaining member. This is, for example, particularly advantageous when cartridges with different lengths are to be used in the drug delivery device. Thus, the drug delivery device may be a reusable device. Manufacturing tolerances in cartridge lengths can thus be compensated by means of the spring washer. Consequently, during operation of the drug delivery device, axial movement of the cartridge in the cartridge retaining member can be reduced or even prevented and dose accuracy can be increased. The spring washer allows securing the cartridge within the cartridge retaining member without requiring much space. Consequently a very compact drug delivery device can be formed.
In a further embodiment, the spring washer is arranged so as to abut the cartridge, preferably on a side of the cartridge that faces the proximal end of the housing.
The spring washer may keep the cartridge fixed in the cartridge retaining member by abutting the cartridge, preferably on a side of the cartridge that faces the proximal end of the housing. Accordingly, axial movement of the cartridge with respect to the cartridge retaining member is reduced or even prevented.
The spring washer may exert a force on the cartridge in the distal direction. The spring washer may be loaded or biased so as to exert the force on the cartridge.
In a further embodiment, the spring washer is fixed to the housing. In particular, the spring washer may be secured to the housing so as to prevent relative axial movement between spring washer and housing in that region in which the spring washer is secured to the housing.
According to this embodiment, the counter force when the spring washer exerts a force on the cartridge acts on the housing with the spring washer being held at its axial position.
In one embodiment, the drug delivery device comprises a piston rod for dispensing a dose of the drug from the device when the piston rod is driven in the distal direction and the spring washer comprises an opening, the opening being arranged so as to allow the piston rod to run through the opening.
In this example, the spring washer can easily be implemented together with conventional drug delivery mechanisms, which utilize a piston rod or the like. Accordingly, the manufacturability of the drug delivery device is facilitated as no significant design changes must be performed.
According to a further embodiment, the spring washer is curved in an axial and/or a radial direction. The axis may extend between the proximal end and the distal end of the housing.
Loading the spring washer and exerting a force on the cartridge is facilitated by shaping the spring washer in this way.
In a further embodiment, the spring washer is a Belleville type spring washer.
Spring washers of this kind can be easily implemented in the drug delivery device.
In one embodiment, the spring washer is fixed to a sleeve member of the housing, preferably a threaded sleeve member of the housing.
According to this embodiment, the spring washer may be implemented in a conventional housing of a drug delivery device, without performing significant design changes on the housing. The (threaded) sleeve member may simultaneously be used to secure the cartridge retaining member to the housing, e.g. by means of an inner thread.
In one embodiment, the drug delivery device comprises a further washer, the further washer preferably being arranged on the proximal side of the spring washer. The further washer is preferably arranged to be abutable by the spring washer.
In one embodiment, the further washer is arranged to limit the loading distance of the spring washer.
During insertion of the cartridge, a force in the proximal direction may be exerted on the spring washer, e.g. when (releasably) securing the cartridge retaining member with the cartridge being retained therein to the housing. In order to prevent the spring washer from being permanently plastically deformed, the further washer can be arranged on the proximal side of the spring washer. The further washer may limit the distance by which the spring washer may be deformed.
In one embodiment, the further washer is a disk washer or a spring washer. If the further washer is a spring washer, it preferably has a higher strength as compared to the spring washer that exerts the force on the cartridge. If the spring washer is loaded by a given force, the risk of overloading the spring washer, e.g. in the region of plastic deformation, can be reduced by providing a further spring washer of higher spring strength.
In one embodiment, the further washer is arranged to limit deformation of the spring washer to elastic deformation. In this example, the spring characteristics of the spring washer can be conserved as no plastic, i.e. non-elastic, deformation takes place.
According to a further embodiment, the further washer is curved in an axial and/or a radial direction. Preferably, the curvature of the further washer corresponds to or resembles the curvature of the spring washer.
In this example, the curvature of the further washer may be adapted to the curvature of spring washer in that region in which the further washer and the spring washer overlap as seen along the axial direction. This allows for a smooth abutment of the spring washer and the further washer.
For the above mentioned aim, a method of manufacturing a drug delivery device comprises the steps of: providing a housing with a proximal end and a distal end, providing a cartridge adapted to accommodate a drug, providing a cartridge retaining member adapted to retain the cartridge, arranging a spring washer within the housing and securing the cartridge retaining member to the housing, thereby loading the spring washer so as to exert a force on the cartridge and to secure the cartridge against displacement, in particular against axial displacement, with respect to the cartridge retaining member.
For the above mentioned aim, a spring washer is used to secure a cartridge which contains a drug in a cartridge retaining member of a drug delivery device against displacement, preferably against axial displacement, with respect to the cartridge retaining member.
Other features will become apparent from the following detailed description when considered in conjunction with the accompanying drawings.
BRIEF DESCRIPTION OF THE FIGURES
FIG. 1 schematically shows a simplified cross sectional side view of a drug delivery device according to an embodiment;
FIG. 2 schematically shows an exploded perspective view of a drug delivery device according to an embodiment;
FIG. 3 schematically shows a detailed cross sectional side view of a part of a drug delivery device according to an embodiment;
FIG. 4 schematically shows a detailed cross sectional side view of a part of a drug delivery device according to an embodiment;
FIG. 5 schematically shows a side view of a spring washer according to an embodiment; and
FIG. 6 schematically shows a side view of a further washer according to an embodiment.
 DETAILED DESCRIPTION
In FIG. 1 an embodiment of a drug delivery device 5 is shown, which is an injector for a liquid medication. The drug delivery device may be configured to deliver a plurality of, preferably user-settable, doses of a drug. The drug delivery device may be a pen-type device. The drug delivery device 5 comprises a housing 10, wherein a cartridge 15 containing a medical product (drug) is located. A needle unit 20 is located at the distal end 25 of the drug delivery device 5. Needle unit 20 may be secured against movement with respect to the housing. Through needle unit 20 the medical product can be injected into a patient.
It should be noted that the description of the drug delivery device 5 as shown in FIG. 1 is merely illustrative.
The drug delivery device as shown in FIG. 1 further comprises a cartridge retaining member 45 which is (releasably) secured to the housing 10. The cartridge retaining member 45 is adapted to retain the cartridge 15 within the drug delivery device 5. The cartridge retaining member 45 can be configured such that the cartridge 15 can be replaced by a user after it has been emptied.
Delivery of the medical product can be performed by means of a piston rod 30 or the like, which can be moved into the distal direction with respect to the cartridge 15. A piston (not explicitly shown) which is retained in the cartridge and seals the cartridge on the proximal end side may be moved in the distal direction with respect to the cartridge by the piston rod. Due to the moving piston, a dose of medical product may be delivered from the cartridge. Piston rod 30 may be threadedly engaged with a (lead screw) nut 35. During operation of the device, nut 35 is secured against rotational movement with respect to the housing 10 by lock nut 36 (cf. FIGS. 2 and 4) which may engage nut 35. Accordingly the piston rod may rotate and translate with respect to the housing when driven in the distal direction. Lock nut 36 and nut 35 may be held in engagement while cartridge retaining member 45 is secured to the housing 10. When the cartridge retaining member is released from the housing 10, nut 35 and lock nut 36 may disengage thereby allowing for rotation of the nut 35 with respect to housing 10. In order to reset the device, e.g. before securing a new and unused cartridge to the housing, piston rod 30 can then be screwed back into its initial position without such a movement being prevented due to engagement of nut 35 and lock nut 36. Thus, resetting of the device is facilitated.
Furthermore, the piston rod 30 is expediently connected to a drive mechanism (not explicitly shown), e.g. a mechanical or electrical drive mechanism, and to a dose setting mechanism (not explicitly shown). Drive mechanism and dose setting mechanism are configured to set a dose of the medical product and to move the piston in the distal direction such that the set dose is dispensed from the cartridge when a dispense button 40 of the drug delivery device is pressed.
When the cartridge 15 has been inserted into the cartridge retaining member 45 and the cartridge retaining member 45 has been secured to the housing, movement of the cartridge 15 in the distal direction is prevented by the cartridge retaining member 45. The cartridge 15 may abut the cartridge retaining member distally.
On the proximal side of the cartridge 15, a spring washer 50 is arranged within the housing 10. Spring washer 50 exerts a force on the cartridge 15 in the distal direction and secures the cartridge 15 against movement with respect to the cartridge retaining member 45 and against movement with respect to the housing 10. The loaded spring washer may hold the cartridge and the cartridge retaining member in permanent abutment on the distal end side of the cartridge 15. As shown in FIG. 1, the spring washer 50 is arranged in abutment with the cartridge 15 on the side of the cartridge which faces the proximal end 65 of the housing 10. Furthermore, the spring washer 50 comprises an opening 55 so as to allow the piston rod 30 to pass through spring washer 50 and to drive delivery of the medical product from the cartridge 15.
The spring washer 50 is fixed to the housing 10 in order to allow for the force to be exerted on the cartridge 15. In order to allow easy manufacturing of the drug delivery device 5, a (threaded) sleeve member 60 can be provided. The spring washer may be fixed to the sleeve member 60, e.g. by fixing elements 52 of the spring washer. The fixing elements 52 may extend in the axial direction. The spring washer may be fixed to the sleeve member 60 on an outer surface of the sleeve member. The sleeve member is fixed to the housing. Spring washer 50 may be fixed to sleeve member 60 by a snap-fit, for example. Sleeve member 60 and/or spring washer 50 is expediently secured against rotational and/or axial movement with respect to the housing. Of course, axial movement of the spring washer 50 for loading the spring washer or during relaxing of the spring washer is allowed. However, the region(s) in which the spring washer 50 is fixed to the housing 10, e.g. fixing elements 52, preferably do not rotate and/or do not move axially during operation of the drug delivery device.
The spring washer 50 may be provided with one, or a plurality of positioning elements. The respective positioning element may serve for keeping the spring washer 50 in a determined orientation, preferably in a predetermined angular orientation, with respect to the housing 10. For example, the fixing elements 52 may serve as positioning elements. The respective positioning element may cooperate with the housing or an element axially and rotationally locked to the housing for keeping the spring washer 50 in the predetermined orientation.
The respective positioning element/fixing element may be oriented axially. The respective positioning element/fixing element may extend from the outer circumference of the spring washer. Two positioning elements/fixing elements may be oppositely disposed. For example, the positioning elements/fixing elements may be arranged and/or axially guided within a respective guide slot (not explicitly shown). The guide slot may be axially and/or rotationally secured to the housing. The guide slot may be axially limited, preferably distally and/or proximally, such that axial movement of the spring washer 50 with respect to the housing 10 may be restricted. The guide slot in cooperation with the positioning elements/fixing element which runs in the slot may rotationally lock the spring washer 50 with respect to the housing 10.
Embodying a helical pressure spring to be rotationally locked with respect to a housing would be considerable more difficult than it is for a spring washer, as the helical spring is usually considerably deformed, in particular in the angular direction, under the influence of an external force. The spring washer may keep its shape in the angular direction even under the influence of considerable forces. Provision of a drug delivery device with accurately aligned parts is facilitated when applying a spring washer which is provided with according positioning elements/fixing elements.
The cartridge retaining member 45 can be secured to the housing 10 via a threaded connection provided between sleeve member 60 and cartridge retaining member 45. Sleeve member 60 is preferably provided with an inner thread for this purpose.
Exerting a force on the cartridge 15 in the distal direction can be performed by loading the spring washer 50 in the proximal direction when the cartridge retaining member 45 with the cartridge is mounted to the housing 10, e.g. by screwing the cartridge retainer into sleeve member. Thus, when the cartridge moves into abutment with the spring washer 50 and spring washer 50 is moved further in the proximal direction together with the cartridge, the spring washer is loaded and exerts a force on the cartridge in the distal direction.
The drug delivery device 5 of the embodiment depicted in FIG. 1 eliminates axial movement of cartridge 15 with respect to the housing 10 and with respect to the cartridge retaining member 45. This is for example advantageous when cartridges 15 with different lengths are used in the drug delivery device 5. It is, for example, possible to compensate for length differences, which may result from manufacturing tolerances between different cartridges or which may be the properties of different cartridge types, e.g. between 0.2 and 2 mm, by applying a spring washer. Consequently, during operation of the drug delivery device 5 axial movement of the cartridge 15 in the cartridge retaining member 45 is prevented and precision of drug delivery is improved.
It should be noted that different configurations of the spring washer 50 regarding its position within the housing 10 can be used for preventing axial movement of the cartridge. For example it is also possible to fix the spring washer 50 to the cartridge retaining member 45 or directly to the housing 10.
In order to ensure that the spring washer is kept in the range of elastic deformation, a further washer 70 can be arranged on the proximal side of the spring washer 50. The further washer 70 can be a disk washer or a spring washer having a higher strength as compared to the spring washer 50.
The further washer 70 limits the movement of the spring washer 50 such that the spring washer 50 is not plastically deformed. Thus, the geometry of the relaxed, i.e. unloaded, spring washer 50 and, in particular, its spring strength remain constant. As shown in FIG. 1, the further washer can be shaped like a disk. It is, however, also conceivable that the further washer has a curvature corresponding to the one of the spring washer 50.
The spring washer may contain metal or may be of metal. The respective spring washer may be made of steel, for example. The spring washer 50 preferably has a spring constant D which is smaller than the spring constant D of the further spring washer 70.
Preferably, the further washer 70 is secured against rotational movement with respect to the housing 10. The further washer does not have to be secured to the housing against axial movement. Rather, the spring washer 50 may limit distal movement of the further washer. An abutment element (not explicitly shown) may limit proximal movement of the further washer with respect to the housing. However, axial movement of the further washer 70 is expediently limited so as to allow the spring washer 50 to abut the further washer 70 and the further washer to abut the housing 10 before the spring washer is plastically deformed.
The embodiment of FIG. 1 is now further explained with reference to FIG. 2. FIG. 2 is an exploded view of the drug delivery device 5 which shows several parts of the drug delivery device 5 in a side view before the parts are inserted into the housing 10. In FIG. 2, the (threaded) sleeve member 60 is shown which has holding means 62 for holding the spring washer 50. The spring washer 50 has two fixing elements 52, e.g. hook shaped, in order to fix the spring washer 50 to the sleeve member 60, for example by the respective fixing element 52 interacting with the respective holding means 62.
Furthermore, in FIG. 2 the (lead screw) nut 35 and the lock nut 36 are shown. The further washer 70 also includes fixing members 72, for securing the further washer against rotational and/or axial movement with respect to the housing 10. The elements shown in FIG. 2 fit into housing 10. The sleeve member 60 may be laser welded to housing 10, for example. As it is immediately apparent from FIG. 2, the spring washer 50 allows securing the cartridge 15 with respect to the housing 10 and within the cartridge retainer without requiring too much space. In particular, spring washer 50 is a lot more space saving than a helical coil spring of equal spring strength. Consequently a very compact drug delivery device 5 can be formed.
With reference to FIG. 3 a further embodiment of the drug delivery device 5 is shown. FIG. 3 shows a detailed view of the spring washer 50 and the further washer 70. As shown in FIG. 3, the further washer 70 can be configured as a disk shaped washer.
Making now reference to FIG. 4 a further embodiment is shown. According to this embodiment the further washer 70 is also formed as a spring washer. The further washer 70 is curved in an axial and/or radial direction in a way that corresponds to or resembles the curvature of the spring washer 50.
In FIG. 5 a detailed view of spring washer 50 is shown. The spring washer 50 is curved in axial and/or radial direction and includes fixing elements 52. Fixing elements 52 may be arranged oppositely with respect to one another. The spring washer can be a Belleville type spring washer.
Making now reference to FIG. 6 the further washer 70 is shown in more detail. The further washer 70 is provided as a disk like washer with fixing members 72 arranged on two opposite sides.
A method of manufacturing the drug delivery device 5 includes the steps of providing a housing with a proximal end and a distal end, providing a cartridge adapted to accommodate a drug, providing a cartridge retaining member adapted to retain the cartridge, arranging a spring washer within the housing and securing the cartridge retaining member to the housing, thereby loading the spring washer so as to exert a force on the cartridge and to secure the cartridge against displacement, in particular against axial displacement, with respect to the cartridge retaining member.
Other implementations are within the scope of the following claims. Elements of different implementations may be combined to form implementations not specifically described herein.

Claims (18)

The invention claimed is:
1. A drug delivery device comprising:
a housing with a proximal end and a distal end,
a cartridge adapted to accommodate a drug,
a cartridge retaining member adapted to retain the cartridge, the cartridge retaining member releasably secured to the housing, and
a spring washer arranged within the housing so as to exert a force on the cartridge and to secure the cartridge against movement with respect to the cartridge retaining member,
wherein the spring washer has at least two fixing elements configured to axially and rotationally fix the spring washer relative to the housing.
2. The drug delivery device according to claim 1, wherein the spring washer is biased so as to exert the force on the cartridge in the distal direction.
3. The drug delivery device according to claim 1, wherein the spring washer is secured against axial movement with respect to the housing.
4. The drug delivery device according to claim 1, wherein the drug delivery device comprises a piston rod for dispensing a dose of the drug from the device when the piston rod is driven in the distal direction and wherein the spring washer comprises an opening, the opening being arranged so as to allow the piston rod to run through the opening.
5. The drug delivery device according to claim 1, wherein the spring washer is curved in an axial and/or radial direction.
6. The drug delivery device according to claim 1, wherein the spring washer is a Belleville type spring washer.
7. The drug delivery device according to claim 1, wherein the spring washer is fixed to a threaded sleeve member of the housing.
8. The drug delivery device according to claim 1, wherein the spring washer being fixed to the housing comprises the spring washer fixed to a threaded sleeve member of the housing and the threaded sleeve member fixed to the housing.
9. The drug delivery device according to claim 1, wherein the at least two fixing elements comprise two oppositely disposed fixing elements which extend in the axial direction.
10. The drug delivery device according to claim 1, wherein the at least two fixing elements are further configured as positioning elements, which keep the spring washer in a determined orientation.
11. The drug delivery device according to claim 1, comprising a further washer, the further washer being arranged on the proximal side of the spring washer.
12. The drug delivery device according to claim 11, wherein the further washer is a disk washer or a further spring washer having a higher strength as compared to the spring washer.
13. The drug delivery device according to claim 11, wherein the further washer is arranged to limit the loading distance of the spring washer.
14. The drug delivery device according to claim 11, wherein the further washer is arranged to limit deformation of the spring washer to elastic deformation.
15. The drug delivery device according to claim 11, wherein the further washer is curved in an axial and/or a radial direction so as to correspond to a curvature of the spring washer.
16. A method of manufacturing a drug delivery device comprising:
providing a housing with a proximal end and a distal end,
providing a cartridge adapted to accommodate a drug,
providing a cartridge retaining member adapted to retain the cartridge and be releasably secured to the housing,
arranging a spring washer within the housing and
releasably securing the cartridge retaining member to the housing, thereby loading the spring washer so as to exert a force on the cartridge and to secure the cartridge against displacement with respect to the cartridge retaining member,
wherein the spring washer has at least two fixing elements configured to axially and rotationally fix the spring washer relative to the housing.
17. A drug delivery device comprising:
a housing with a proximal end and a distal end,
a cartridge adapted to accommodate a drug,
a cartridge retaining member adapted to retain the cartridge, the cartridge retaining member is secured to the housing, and
a spring washer arranged within the housing so as to exert a force on the cartridge and to secure the cartridge against movement with respect to the cartridge retaining member,
wherein the spring washer has at least two fixing elements configured to axially and rotationally fix the spring washer relative to the housing.
18. A drug delivery device comprising:
a housing with a proximal end and a distal end,
a cartridge configured to accommodate a drug,
a cartridge retaining member configured to accept and retain the cartridge, the cartridge retaining member is secured to the housing, and
a spring washer comprising at least two fixing elements configured to fix the spring washer from movement with respect to the housing, where the spring washer is positioned axially within the housing so as to exert a force on the cartridge to secure the cartridge against movement with respect to the cartridge retaining member, where the fixing elements allow axial loading of the spring washer when the cartridge retaining member is secured to the housing.
US14/934,406 2008-10-13 2009-10-08 Drug delivery device and method of manufacturing a drug delivery device Active 2032-11-11 USRE47614E1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/934,406 USRE47614E1 (en) 2008-10-13 2009-10-08 Drug delivery device and method of manufacturing a drug delivery device

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP08017889 2008-10-13
EP08017889 2008-10-13
PCT/EP2009/063075 WO2010043533A1 (en) 2008-10-13 2009-10-08 Drug delivery device and method of manufacturing a drug delivery device
US13/123,530 US9132237B2 (en) 2008-10-13 2009-10-08 Drug delivery device and method of manufacturing a drug delivery device
US14/934,406 USRE47614E1 (en) 2008-10-13 2009-10-08 Drug delivery device and method of manufacturing a drug delivery device

Publications (1)

Publication Number Publication Date
USRE47614E1 true USRE47614E1 (en) 2019-09-24

Family

ID=40513417

Family Applications (3)

Application Number Title Priority Date Filing Date
US14/934,406 Active 2032-11-11 USRE47614E1 (en) 2008-10-13 2009-10-08 Drug delivery device and method of manufacturing a drug delivery device
US13/123,530 Active 2032-11-11 US9132237B2 (en) 2008-10-13 2009-10-08 Drug delivery device and method of manufacturing a drug delivery device
US13/440,203 Active 2030-11-22 US9078970B2 (en) 2008-10-13 2012-04-05 Drug delivery device and method of manufacturing a drug delivery device

Family Applications After (2)

Application Number Title Priority Date Filing Date
US13/123,530 Active 2032-11-11 US9132237B2 (en) 2008-10-13 2009-10-08 Drug delivery device and method of manufacturing a drug delivery device
US13/440,203 Active 2030-11-22 US9078970B2 (en) 2008-10-13 2012-04-05 Drug delivery device and method of manufacturing a drug delivery device

Country Status (24)

Country Link
US (3) USRE47614E1 (en)
EP (2) EP2468344B1 (en)
JP (1) JP5777518B2 (en)
KR (1) KR101677065B1 (en)
CN (1) CN102245235B (en)
AU (1) AU2009304105B2 (en)
BR (2) BR122019007473B8 (en)
CA (1) CA2740331C (en)
CY (2) CY1113363T1 (en)
DE (1) DE202009019078U1 (en)
DK (2) DK2346552T4 (en)
ES (2) ES2393173T5 (en)
HK (1) HK1160804A1 (en)
IL (1) IL212255A (en)
MX (1) MX2011003906A (en)
MY (1) MY152436A (en)
NZ (1) NZ592172A (en)
PL (2) PL2346552T5 (en)
PT (2) PT2346552E (en)
RU (1) RU2534610C2 (en)
SI (2) SI2468344T1 (en)
TW (2) TWI636809B (en)
WO (1) WO2010043533A1 (en)
ZA (1) ZA201102541B (en)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040103930A (en) 2002-02-11 2004-12-09 앤태어스 파머, 인코퍼레이티드 Intradermal injector
CN101132820B (en) 2005-01-24 2010-05-19 安塔雷斯制药公司 Prefilled needle assisted jet injector
WO2007131013A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Two-stage reconstituting injector
US9144648B2 (en) 2006-05-03 2015-09-29 Antares Pharma, Inc. Injector with adjustable dosing
ES2679674T3 (en) 2008-01-11 2018-08-30 Ucb Biopharma Sprl Systems for administering medication for patients with rheumatoid arthritis
CA2718053C (en) 2008-03-10 2016-09-27 Antares Pharma, Inc. Injector safety device
WO2010017285A2 (en) 2008-08-05 2010-02-11 Antares Pharma, Inc. Multiple dosage injector
KR101677065B1 (en) 2008-10-13 2016-11-29 사노피-아벤티스 도이칠란트 게엠베하 Drug delivery device and method of manufacturing a drug delivery device
CA2755779C (en) 2009-03-20 2015-11-10 Antares Pharma, Inc. Hazardous agent injection system
US9457150B2 (en) * 2009-06-01 2016-10-04 Sanofi-Aventis Deutschland Gmbh Biasing mechanism for a drug delivery device
GB2475917B (en) * 2009-12-07 2015-12-16 Medical House Ltd Syringe flange protector
TWI459986B (en) * 2010-11-08 2014-11-11 Shl Group Ab Container holder assembly
US9173999B2 (en) 2011-01-26 2015-11-03 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
SG193448A1 (en) 2011-03-16 2013-10-30 Becton Dickinson Co Multiple use disposable injection pen
US10258740B2 (en) 2011-06-02 2019-04-16 Ucb Biopharma Sprl Auto-injector
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
CH705345A2 (en) 2011-08-04 2013-02-15 Tecpharma Licensing Ag Injector with needle protection device.
KR20150003179A (en) 2012-03-06 2015-01-08 안타레스 팔마, 인코퍼레이티드 Prefilled syringe with breakaway force feature
US11577029B2 (en) 2012-03-15 2023-02-14 Becton, Dickinson And Company Multiple use disposable injection pen
CN104487114A (en) 2012-04-06 2015-04-01 安塔雷斯药品公司 Needle assisted jet injection administration of testosterone compositions
KR20170005896A (en) * 2012-04-18 2017-01-16 케어베이 유럽 리미티드 Medicament delivery device
US9364611B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9522235B2 (en) 2012-05-22 2016-12-20 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
USD726901S1 (en) 2012-07-30 2015-04-14 Ucb Pharma S.A. Drive device for administering medication
EP2879736B1 (en) 2012-07-30 2018-11-14 UCB Biopharma SPRL Auto-injector
WO2014019999A1 (en) * 2012-07-30 2014-02-06 Ucb Pharma S.A. Auto-injector
WO2014019997A1 (en) 2012-07-30 2014-02-06 Ucb Pharma S.A. Auto-injector
WO2014020001A1 (en) 2012-07-30 2014-02-06 Ucb Pharma S.A. Auto-injector
WO2014108551A1 (en) * 2013-01-14 2014-07-17 Sanofi-Aventis Deutschland Gmbh Drive mechanism of a drug delivery device comprising an accessory drive
US9744302B2 (en) 2013-02-11 2017-08-29 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
EP2968792B1 (en) 2013-03-11 2019-05-15 Antares Pharma, Inc. Dosage injector with pinion system
WO2014165136A1 (en) 2013-03-12 2014-10-09 Antares Pharma, Inc. Constant volume prefilled syringes and kits thereof
EP3590568A1 (en) 2013-03-22 2020-01-08 TecPharma Licensing AG Substance dispensing device with a signalling device
EP2996743B1 (en) * 2013-05-16 2018-12-19 Sanofi-Aventis Deutschland GmbH Assembly for a drug delivery device and drug delivery device
WO2015110532A1 (en) 2014-01-27 2015-07-30 Ucb Biopharma Sprl Auto-injector
EP3099350B1 (en) * 2014-01-27 2019-06-12 UCB Biopharma SPRL Auto-injector
WO2015110533A2 (en) 2014-01-27 2015-07-30 Ucb Biopharma Sprl Auto-injector
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
CH710784A2 (en) 2015-02-26 2016-08-31 Tecpharma Licensing Ag Carpule holder to receive a carpule and for attachment to a drive and / or a metering device and / or on a housing of an injection device.
CA2980004A1 (en) 2015-03-24 2016-09-29 Kaleo, Inc. Devices and methods for delivering a lyophilized medicament
TW201707738A (en) 2015-06-03 2017-03-01 賽諾菲阿凡提斯德意志有限公司 Syringe support and autoinjector
TW201703802A (en) 2015-06-03 2017-02-01 賽諾菲阿凡提斯德意志有限公司 Syringe support and autoinjector
CA2990950A1 (en) 2015-06-30 2017-01-05 Kaleo, Inc. Auto-injectors for administration of a medicament within a prefilled syringe
US10898646B2 (en) 2016-04-29 2021-01-26 Shl Medical Ag Container holder assembly
JP7188877B2 (en) * 2016-09-19 2022-12-13 ウエスト・ファーマ．サービシーズ・イスラエル，リミテッド Rotational Resistance Friction Adapter for Plunger Drivers of Drug Delivery Devices
JP7014797B2 (en) 2016-12-23 2022-02-01 カレオ，インコーポレイテッド Drug delivery devices and methods for delivering drugs to babies and children
EP3597233A1 (en) * 2018-07-18 2020-01-22 Sanofi Drug delivery devices
EP3597241A1 (en) * 2018-07-18 2020-01-22 Sanofi Drug delivery device and method to modify a drug delivery device
US20210008282A1 (en) * 2019-07-09 2021-01-14 Becton, Dickinson And Company Self-Controllable Load Spring Washer
AU2020331302A1 (en) 2019-08-09 2022-01-06 Kaleo, Inc. Devices and methods for delivery of substances within a prefilled syringe
EP3808393A1 (en) * 2019-10-15 2021-04-21 Ypsomed AG Cartridge fixation for a drug delivery device
CH717876A2 (en) * 2020-09-16 2022-03-31 Ypsomed Ag Injection device for administering a fluid product.
CA3193448A1 (en) * 2020-09-25 2022-03-31 Roger Groskopf Medical injection device with a retained biasing component
WO2022066895A1 (en) * 2020-09-25 2022-03-31 Becton, Dickinson And Company Biasing member for medical injection device
AU2021347245A1 (en) * 2020-09-25 2023-05-04 Becton, Dickinson And Company Medical injection device having a biasing component engageable with a plunger rod
WO2022066901A1 (en) * 2020-09-25 2022-03-31 Becton, Dickinson And Company Biasing member for medical injection device

Citations (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US533575A (en) 1895-02-05 wilkens
US2461481A (en) * 1944-05-26 1949-02-08 Roberts Mfg Company Hypodermic syringe
GB743839A (en) 1953-02-22 1956-01-25 Hubert Percival Schofield Improvements in or relating to devices for dispensing or delivering predetermined quantities of liquids from cartridges or the like containers
US3742948A (en) 1969-08-25 1973-07-03 Philips Corp Hypodermic syringe with radially movable blocking elements
US4490142A (en) * 1983-08-22 1984-12-25 Silvern Rubin D Carpule syringe with rapidly acting mechanism for controllably _positively retaining the hub of a hypodermic needle
US4865591A (en) 1987-06-12 1989-09-12 Hypoguard (Uk) Limited Measured dose dispensing device
US4931043A (en) * 1988-08-08 1990-06-05 Sterling Drug Inc. Ratchet connector for hypodermic syringe pistons
US5092842A (en) 1987-05-08 1992-03-03 Wilhelm Haselmeier Gmbh & Co. Injection device with a cocking element and a second setting element
EP0496141A1 (en) 1991-01-22 1992-07-29 Eli Lilly And Company Multiple dose injection pen
WO1993007922A1 (en) 1991-10-18 1993-04-29 Novo Nordisk A/S Large dose pen
US5226895A (en) 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
US5226896A (en) 1990-04-04 1993-07-13 Eli Lilly And Company Dose indicating injection pen
WO1993024160A1 (en) 1992-06-01 1993-12-09 Habley Medical Technology Corporation Dose setting and repeating syringe
RU2004256C1 (en) 1991-06-26 1993-12-15 Липов Борис Петрович, Сафронов Игорь Николаевич Injector
US5279586A (en) 1992-02-04 1994-01-18 Becton, Dickinson And Company Reusable medication delivery pen
JPH067741U (en) 1992-07-02 1994-02-01 テルモ株式会社 Drug dispenser
US5304152A (en) 1990-03-29 1994-04-19 Bernard Sams Dispensing device
US5320609A (en) 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
US5378233A (en) 1992-11-18 1995-01-03 Habley Medical Technology Corporation Selected dose pharmaceutical dispenser
US5383865A (en) 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
US5391157A (en) 1992-10-20 1995-02-21 Eli Lilly And Company End of dose indicator
WO1995021645A1 (en) 1994-02-14 1995-08-17 Genentech, Inc. Self administered injection pen apparatus and method
US5480387A (en) 1991-07-24 1996-01-02 Medico Development Investment Company Injection device
US5505704A (en) 1993-04-02 1996-04-09 Eli Lilly And Company Manifold medication injection apparatus and method
RU2060736C1 (en) 1994-12-09 1996-05-27 Научно-учебно-производственное объединение ТОО "Мединфодент" Stomatologic syringe
US5582598A (en) 1994-09-19 1996-12-10 Becton Dickinson And Company Medication delivery pen with variable increment dose scale
US5674204A (en) 1995-09-19 1997-10-07 Becton Dickinson And Company Medication delivery pen cap actuated dose delivery clutch
US5688251A (en) 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
US5807346A (en) 1993-02-08 1998-09-15 Laboratoire Aguettant Metering instrument, particularly for injecting medicinal liquid
US5820602A (en) 1995-09-08 1998-10-13 Visionary Medical Products, Inc. Pen-type injector drive mechanism
CA2138528C (en) 1992-07-31 1998-12-15 Terry M. Haber Reusable pharmaceutical dispenser with full stroke indicator
US5851079A (en) 1996-10-25 1998-12-22 The Procter & Gamble Company Simplified undirectional twist-up dispensing device with incremental dosing
EP0897729A2 (en) 1997-08-11 1999-02-24 Becton, Dickinson and Company Medication delivery pen having a controlling means of the torque applied to the dosing elements
WO1999038554A1 (en) 1998-01-30 1999-08-05 Novo Nordisk A/S An injection syringe
EP0937476A2 (en) 1998-02-23 1999-08-25 Becton, Dickinson and Company Low-cost medication delivery pen
EP0937471A2 (en) 1998-02-20 1999-08-25 Becton Dickinson and Company Medication delivery pen
US5961495A (en) 1998-02-20 1999-10-05 Becton, Dickinson And Company Medication delivery pen having a priming mechanism
JPH11514242A (en) 1993-07-31 1999-12-07 ウェストン メディカル リミテッド Needleless syringe
CA2359375A1 (en) 1999-01-14 2000-07-20 B D Medico S.A.R.L. Injection device
US6095572A (en) * 1998-01-20 2000-08-01 Optimize Technologies, Inc. Quarter turn quick connect fitting
WO2001010484A1 (en) 1999-08-05 2001-02-15 Becton, Dickinson And Company Medication delivery pen
US6193698B1 (en) 1997-07-18 2001-02-27 Disetronic Licensing Ag System for locking a dosing button in a device for the adminstration of a product to be injected
US6221046B1 (en) 1995-03-07 2001-04-24 Eli Lilly And Company Recyclable medication dispensing device
US20010007338A1 (en) * 2000-01-12 2001-07-12 Roger Popp Gaseous fuel injector having high heat tolerance
WO2002030495A2 (en) 2000-10-09 2002-04-18 Eli Lilly And Company Pen device for administration of parathyroid hormone
US20020052578A1 (en) 2000-06-16 2002-05-02 Moller Claus Schmidt Injection device
US20020120235A1 (en) 2001-01-05 2002-08-29 Christian Enggaard Automatic injection device with reset feature
WO2002092153A2 (en) 2001-05-16 2002-11-21 Eli Lilly And Company Medication injector apparatus with drive assembly that facilitates reset
US20030050609A1 (en) 2000-03-24 2003-03-13 Bernard Sams One-way clutch mechanisms and injector devices
US6562006B1 (en) 1999-04-16 2003-05-13 Pharmacia Ab Injector device and method for its operation
US6585685B2 (en) 2001-06-08 2003-07-01 Bioject Inc. Jet injector apparatus and method
US6613023B2 (en) 1999-01-12 2003-09-02 Disetronic Licensing Ag Device for administering an injectable product in doses
WO2003080160A1 (en) 2002-03-18 2003-10-02 Eli Lilly And Company Medication dispensing apparatus with gear set for mechanical advantage
US20040035491A1 (en) 2002-08-26 2004-02-26 Penjet Corporation Method and apparatus for needle-less injection with a degassed fluid
US6699224B2 (en) 1999-01-12 2004-03-02 Disetronic Licensing Ag Device for administering an injectable product
WO2004062715A2 (en) 2003-01-07 2004-07-29 Becton Dickinson And Company Disposable injection device
US20040267207A1 (en) 2003-03-03 2004-12-30 Veasey Robert Frederick Drive mechanisms suitable for use in drug delivery devices
WO2005032449A1 (en) 2003-10-03 2005-04-14 Novo Nordisk A/S Container comprising code information elements
US6932794B2 (en) 2003-04-03 2005-08-23 Becton, Dickinson And Company Medication delivery pen
US20050267422A1 (en) 2004-05-26 2005-12-01 Kriesel Marshall S Fluid delivery apparatus
DE102004053529A1 (en) 2004-11-05 2006-05-11 Tecpharma Licensing Ag Blood withdrawal device for use by patient, has drive unit coupled with piston, which is movable in blood container, and detachable locking device, which prevents movement of piston by drive unit
US20060153693A1 (en) 2004-12-31 2006-07-13 Patrick Fiechter Administering apparatus comprising a service life timer
WO2006084876A1 (en) 2005-02-11 2006-08-17 Novo Nordisk A/S Injection device
DE102005032705A1 (en) 2005-05-24 2006-11-30 Tecpharma Licensing Ag Dosing device for the administration of an injectable product, comprises a radially movable threaded rod that carries teeth and rotation limiting element, which is connected to the injection device
US20070005021A1 (en) 2005-07-01 2007-01-04 Philippe Kohlbrenner Magnetic plunger rod re-setting mechanism and plunger rod lock
US20070016143A1 (en) 2003-12-08 2007-01-18 Novo Nordisk A/S Medical delivery device having air shot means
US7169132B2 (en) 2002-10-01 2007-01-30 Becton, Dickinson And Company Medication delivery pen
US20070142789A1 (en) 2001-07-16 2007-06-21 Fisher Mark J Medication dispensing apparatus configured for rotate to prime and pull/push to inject functionality
WO2008008694A2 (en) 2006-07-11 2008-01-17 Eli Lilly And Company Needle mounting assembly for a medication injection device
US7337796B2 (en) 2001-06-19 2008-03-04 Mercer Valve Company, Inc. Safety relief valve having a low blow-down value and spring therefore
EP1974761A2 (en) 2003-03-03 2008-10-01 DCA Design International Limited Pen-type injector with dose dial sleeve
US20090275916A1 (en) 2008-05-02 2009-11-05 Sanofi-Aventis Deutschland Gmbh Medication Delivery Device
WO2010043533A1 (en) 2008-10-13 2010-04-22 Sanofi-Aventis Deutschland Gmbh Drug delivery device and method of manufacturing a drug delivery device
WO2010139635A1 (en) 2009-06-01 2010-12-09 Sanofi-Aventis Deutschland Gmbh Biasing mechanism for a cartridge of a drug delivery service
US8092420B2 (en) * 2004-11-24 2012-01-10 Becton, Dickinson And Company Automatic reconstitution injector device
US8187233B2 (en) 2008-05-02 2012-05-29 Sanofi-Aventis Deutschland Gmbh Medication delivery device
US9180250B2 (en) * 2009-10-30 2015-11-10 Sanofi-Aventis Deutschland Gmbh Drug delivery device
US9375535B2 (en) * 2009-09-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device
US20170119971A1 (en) * 2014-07-01 2017-05-04 Sanofi Clicker arrangement and drug delivery device herewith
US20170128673A1 (en) * 2014-07-01 2017-05-11 Sanofi Drug Delivery Device
US20170136182A1 (en) * 2014-07-01 2017-05-18 Sanofi Spring arrangement and drug delivery device herewith
US20170136186A1 (en) * 2014-07-01 2017-05-18 Sanofi Drug Delivery Device
US20170151392A1 (en) * 2014-07-01 2017-06-01 Sanofi Drug Delivery Device
US20170340835A1 (en) * 2014-11-24 2017-11-30 Sanofi Drug delivery device with variable piston force
US20170340830A1 (en) * 2014-12-12 2017-11-30 Carebay Europe Ltd. Dose Setting Mechanism and Medicament Delivery Device Comprising the Dose Setting Mechanism

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472022A (en) * 1993-11-02 1995-12-05 Genentech, Inc. Injection pen solution transfer apparatus and method
TW572761B (en) * 2002-07-17 2004-01-21 Ming-Jeng Shiu Syringe with retraction force
JP3908150B2 (en) * 2002-11-11 2007-04-25 株式会社トップ Syringe pump
TWI256900B (en) * 2004-04-30 2006-06-21 Ming-Jeng Shiu Syringe with withdrawal force

Patent Citations (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US533575A (en) 1895-02-05 wilkens
US2461481A (en) * 1944-05-26 1949-02-08 Roberts Mfg Company Hypodermic syringe
GB743839A (en) 1953-02-22 1956-01-25 Hubert Percival Schofield Improvements in or relating to devices for dispensing or delivering predetermined quantities of liquids from cartridges or the like containers
US3742948A (en) 1969-08-25 1973-07-03 Philips Corp Hypodermic syringe with radially movable blocking elements
US4490142A (en) * 1983-08-22 1984-12-25 Silvern Rubin D Carpule syringe with rapidly acting mechanism for controllably _positively retaining the hub of a hypodermic needle
US5092842A (en) 1987-05-08 1992-03-03 Wilhelm Haselmeier Gmbh & Co. Injection device with a cocking element and a second setting element
US4865591A (en) 1987-06-12 1989-09-12 Hypoguard (Uk) Limited Measured dose dispensing device
US4931043A (en) * 1988-08-08 1990-06-05 Sterling Drug Inc. Ratchet connector for hypodermic syringe pistons
US5226895A (en) 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
US5304152A (en) 1990-03-29 1994-04-19 Bernard Sams Dispensing device
US5226896A (en) 1990-04-04 1993-07-13 Eli Lilly And Company Dose indicating injection pen
EP0496141A1 (en) 1991-01-22 1992-07-29 Eli Lilly And Company Multiple dose injection pen
RU2004256C1 (en) 1991-06-26 1993-12-15 Липов Борис Петрович, Сафронов Игорь Николаевич Injector
US5480387A (en) 1991-07-24 1996-01-02 Medico Development Investment Company Injection device
US5626566A (en) 1991-10-18 1997-05-06 Novo Nordisk A/S Large dose pen
WO1993007922A1 (en) 1991-10-18 1993-04-29 Novo Nordisk A/S Large dose pen
US5279586A (en) 1992-02-04 1994-01-18 Becton, Dickinson And Company Reusable medication delivery pen
WO1993024160A1 (en) 1992-06-01 1993-12-09 Habley Medical Technology Corporation Dose setting and repeating syringe
JPH067741U (en) 1992-07-02 1994-02-01 テルモ株式会社 Drug dispenser
CA2138528C (en) 1992-07-31 1998-12-15 Terry M. Haber Reusable pharmaceutical dispenser with full stroke indicator
US5391157A (en) 1992-10-20 1995-02-21 Eli Lilly And Company End of dose indicator
US5378233A (en) 1992-11-18 1995-01-03 Habley Medical Technology Corporation Selected dose pharmaceutical dispenser
US5320609A (en) 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
US5807346A (en) 1993-02-08 1998-09-15 Laboratoire Aguettant Metering instrument, particularly for injecting medicinal liquid
US5383865A (en) 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
US5505704A (en) 1993-04-02 1996-04-09 Eli Lilly And Company Manifold medication injection apparatus and method
US20040254526A1 (en) 1993-07-31 2004-12-16 Aradigm Corporation Needle-less injector
JPH11514242A (en) 1993-07-31 1999-12-07 ウェストン メディカル リミテッド Needleless syringe
WO1995021645A1 (en) 1994-02-14 1995-08-17 Genentech, Inc. Self administered injection pen apparatus and method
US5582598A (en) 1994-09-19 1996-12-10 Becton Dickinson And Company Medication delivery pen with variable increment dose scale
WO1996017640A1 (en) 1994-12-09 1996-06-13 Medinfodent Ltd. Syringe
RU2060736C1 (en) 1994-12-09 1996-05-27 Научно-учебно-производственное объединение ТОО "Мединфодент" Stomatologic syringe
US5891106A (en) 1994-12-09 1999-04-06 Medinfodent Ltd. Syringe
US6221046B1 (en) 1995-03-07 2001-04-24 Eli Lilly And Company Recyclable medication dispensing device
US5820602A (en) 1995-09-08 1998-10-13 Visionary Medical Products, Inc. Pen-type injector drive mechanism
US5688251A (en) 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
US5674204A (en) 1995-09-19 1997-10-07 Becton Dickinson And Company Medication delivery pen cap actuated dose delivery clutch
US5851079A (en) 1996-10-25 1998-12-22 The Procter & Gamble Company Simplified undirectional twist-up dispensing device with incremental dosing
US6193698B1 (en) 1997-07-18 2001-02-27 Disetronic Licensing Ag System for locking a dosing button in a device for the adminstration of a product to be injected
US5921966A (en) 1997-08-11 1999-07-13 Becton Dickinson And Company Medication delivery pen having an improved clutch assembly
US5957896A (en) 1997-08-11 1999-09-28 Becton, Dickinson And Company Medication delivery pen
EP0897729A2 (en) 1997-08-11 1999-02-24 Becton, Dickinson and Company Medication delivery pen having a controlling means of the torque applied to the dosing elements
US6361687B1 (en) * 1998-01-20 2002-03-26 Optimize Technologies, Inc. Quarter turn quick connect fitting
US6095572A (en) * 1998-01-20 2000-08-01 Optimize Technologies, Inc. Quarter turn quick connect fitting
US6004297A (en) 1998-01-30 1999-12-21 Novo Nordisk A/S Injection syringe
WO1999038554A1 (en) 1998-01-30 1999-08-05 Novo Nordisk A/S An injection syringe
US6235004B1 (en) 1998-01-30 2001-05-22 Novo Nordisk A/S Injection syringe
US5961495A (en) 1998-02-20 1999-10-05 Becton, Dickinson And Company Medication delivery pen having a priming mechanism
EP0937471A2 (en) 1998-02-20 1999-08-25 Becton Dickinson and Company Medication delivery pen
US6248095B1 (en) 1998-02-23 2001-06-19 Becton, Dickinson And Company Low-cost medication delivery pen
EP0937476A2 (en) 1998-02-23 1999-08-25 Becton, Dickinson and Company Low-cost medication delivery pen
US6613023B2 (en) 1999-01-12 2003-09-02 Disetronic Licensing Ag Device for administering an injectable product in doses
US6699224B2 (en) 1999-01-12 2004-03-02 Disetronic Licensing Ag Device for administering an injectable product
CA2359375A1 (en) 1999-01-14 2000-07-20 B D Medico S.A.R.L. Injection device
US6562006B1 (en) 1999-04-16 2003-05-13 Pharmacia Ab Injector device and method for its operation
US6936032B1 (en) 1999-08-05 2005-08-30 Becton, Dickinson And Company Medication delivery pen
WO2001010484A1 (en) 1999-08-05 2001-02-15 Becton, Dickinson And Company Medication delivery pen
US6425532B1 (en) * 2000-01-12 2002-07-30 Woodward Governor Company Gaseous fuel injector having spring loaded metal seal
US20010007338A1 (en) * 2000-01-12 2001-07-12 Roger Popp Gaseous fuel injector having high heat tolerance
US20030050609A1 (en) 2000-03-24 2003-03-13 Bernard Sams One-way clutch mechanisms and injector devices
US6899698B2 (en) 2000-03-24 2005-05-31 Bernard Sams One-way clutch mechanisms and injector devices
US20020052578A1 (en) 2000-06-16 2002-05-02 Moller Claus Schmidt Injection device
US7241278B2 (en) 2000-06-16 2007-07-10 Novo Nordisk A/S Injection device
US20040059299A1 (en) 2000-06-16 2004-03-25 Moller Claus Schmidt Injection device
WO2002030495A2 (en) 2000-10-09 2002-04-18 Eli Lilly And Company Pen device for administration of parathyroid hormone
US20040097883A1 (en) 2000-10-09 2004-05-20 Roe Michael Joseph Pen device for administration of parathyroid hormone
US20020120235A1 (en) 2001-01-05 2002-08-29 Christian Enggaard Automatic injection device with reset feature
WO2002092153A2 (en) 2001-05-16 2002-11-21 Eli Lilly And Company Medication injector apparatus with drive assembly that facilitates reset
US20040210199A1 (en) 2001-05-16 2004-10-21 Atterbury William Goodwin Medication injector apparatus with drive assembly that facilitates reset
EP1776975A2 (en) 2001-05-16 2007-04-25 Eli Lilly & Company Medication injector apparatus with drive assembly that facilitates reset
US6585685B2 (en) 2001-06-08 2003-07-01 Bioject Inc. Jet injector apparatus and method
US7337796B2 (en) 2001-06-19 2008-03-04 Mercer Valve Company, Inc. Safety relief valve having a low blow-down value and spring therefore
US20070142789A1 (en) 2001-07-16 2007-06-21 Fisher Mark J Medication dispensing apparatus configured for rotate to prime and pull/push to inject functionality
WO2003080160A1 (en) 2002-03-18 2003-10-02 Eli Lilly And Company Medication dispensing apparatus with gear set for mechanical advantage
US7678084B2 (en) 2002-03-18 2010-03-16 Eli Lilly And Company Medication dispensing apparatus with gear set for mechanical advantage
US20040035491A1 (en) 2002-08-26 2004-02-26 Penjet Corporation Method and apparatus for needle-less injection with a degassed fluid
US7169132B2 (en) 2002-10-01 2007-01-30 Becton, Dickinson And Company Medication delivery pen
WO2004062715A2 (en) 2003-01-07 2004-07-29 Becton Dickinson And Company Disposable injection device
US7850662B2 (en) 2003-03-03 2010-12-14 Sanofi-Aventis Deutschland Gmbh Drive mechanisms suitable for use in drug delivery devices
US20040267207A1 (en) 2003-03-03 2004-12-30 Veasey Robert Frederick Drive mechanisms suitable for use in drug delivery devices
US20050113765A1 (en) 2003-03-03 2005-05-26 Veasey Robert F. Pen-type injector
EP1974761A2 (en) 2003-03-03 2008-10-01 DCA Design International Limited Pen-type injector with dose dial sleeve
US6932794B2 (en) 2003-04-03 2005-08-23 Becton, Dickinson And Company Medication delivery pen
WO2005032449A1 (en) 2003-10-03 2005-04-14 Novo Nordisk A/S Container comprising code information elements
US20070016143A1 (en) 2003-12-08 2007-01-18 Novo Nordisk A/S Medical delivery device having air shot means
US20050267422A1 (en) 2004-05-26 2005-12-01 Kriesel Marshall S Fluid delivery apparatus
DE102004053529A1 (en) 2004-11-05 2006-05-11 Tecpharma Licensing Ag Blood withdrawal device for use by patient, has drive unit coupled with piston, which is movable in blood container, and detachable locking device, which prevents movement of piston by drive unit
US8092420B2 (en) * 2004-11-24 2012-01-10 Becton, Dickinson And Company Automatic reconstitution injector device
US20060153693A1 (en) 2004-12-31 2006-07-13 Patrick Fiechter Administering apparatus comprising a service life timer
WO2006084876A1 (en) 2005-02-11 2006-08-17 Novo Nordisk A/S Injection device
DE102005032705A1 (en) 2005-05-24 2006-11-30 Tecpharma Licensing Ag Dosing device for the administration of an injectable product, comprises a radially movable threaded rod that carries teeth and rotation limiting element, which is connected to the injection device
US20070021718A1 (en) 2005-05-24 2007-01-25 Stefan Burren Plastic spring
US20070005021A1 (en) 2005-07-01 2007-01-04 Philippe Kohlbrenner Magnetic plunger rod re-setting mechanism and plunger rod lock
WO2008008694A2 (en) 2006-07-11 2008-01-17 Eli Lilly And Company Needle mounting assembly for a medication injection device
US20090275916A1 (en) 2008-05-02 2009-11-05 Sanofi-Aventis Deutschland Gmbh Medication Delivery Device
US8187233B2 (en) 2008-05-02 2012-05-29 Sanofi-Aventis Deutschland Gmbh Medication delivery device
TW201019980A (en) 2008-10-13 2010-06-01 Sanofi Aventis Deutschland Drug delivery device and method of manufacturing a drug delivery device
US9132237B2 (en) * 2008-10-13 2015-09-15 Sanofi-Aventis Deutschland Gmbh Drug delivery device and method of manufacturing a drug delivery device
WO2010043533A1 (en) 2008-10-13 2010-04-22 Sanofi-Aventis Deutschland Gmbh Drug delivery device and method of manufacturing a drug delivery device
EP2346552A1 (en) 2008-10-13 2011-07-27 Sanofi-Aventis Deutschland GmbH Drug delivery device and method of manufacturing a drug delivery device
US20110306939A1 (en) * 2008-10-13 2011-12-15 Sanofi-Aventis Deutschland Gmbh Drug delivery device and method of manufacturing a drug delivery device
US20120191049A1 (en) * 2008-10-13 2012-07-26 Sanofi-Aventis Deutschland Gmbh Drug delivery device and method of manufacturing a drug delivery device
US9078970B2 (en) * 2008-10-13 2015-07-14 Sanofi-Aventis Deutschland Gmbh Drug delivery device and method of manufacturing a drug delivery device
WO2010139635A1 (en) 2009-06-01 2010-12-09 Sanofi-Aventis Deutschland Gmbh Biasing mechanism for a cartridge of a drug delivery service
US9375535B2 (en) * 2009-09-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device
US9180250B2 (en) * 2009-10-30 2015-11-10 Sanofi-Aventis Deutschland Gmbh Drug delivery device
US20170119971A1 (en) * 2014-07-01 2017-05-04 Sanofi Clicker arrangement and drug delivery device herewith
US20170128673A1 (en) * 2014-07-01 2017-05-11 Sanofi Drug Delivery Device
US20170136182A1 (en) * 2014-07-01 2017-05-18 Sanofi Spring arrangement and drug delivery device herewith
US20170136186A1 (en) * 2014-07-01 2017-05-18 Sanofi Drug Delivery Device
US20170151392A1 (en) * 2014-07-01 2017-06-01 Sanofi Drug Delivery Device
US20170340835A1 (en) * 2014-11-24 2017-11-30 Sanofi Drug delivery device with variable piston force
US20170340830A1 (en) * 2014-12-12 2017-11-30 Carebay Europe Ltd. Dose Setting Mechanism and Medicament Delivery Device Comprising the Dose Setting Mechanism

Non-Patent Citations (25)

* Cited by examiner, † Cited by third party
Title
‘bokers.com’ [online], "Wave Spring Washers", retrieved on Sep. 30, 2015, retrieved from: URL<http://www.bokers.com/wave_spring_washers.asp>, 1 page.
"Beitz and Grote", "Dubbel, Pocketbook for mechanical engineering", 1997, 16 pages.
"Pen-injectors for medical use—Part 1: Pen-injectors—Requirements and test methods," International Standard, reference No. ISO 11608-1:2000(E), first edition Dec. 15, 2000, 32 pages.
Barrett, "Fastener Design Manual," NASA Reference Publication 1228, Published Mar. 1990, 2 pages.
Beitz and Grote, "Taschenbuch fur den Maschinebau," Dubbel, Published 1997, G55-G57, 5 pages.
Beitz, W., et al., "Taschenbuch fur den Maschinenbau," Dubben-Handbook of Mechanical Engineering, pp. G55-G57, 1997.
Boker's Inc., Wave Spring Washers [online] [retrieved on Sep. 30, 2015]; Retrieved from the Internet: <URL:https://www.bokers.com/wave_spring_washers.asp>.
Canadian Examination Search Report for CA App. No. 2740331, dated Jul. 13, 2015.
Chinese Office Action for CN App. No. 200980149971.X, dated Jan. 7, 2013.
European Search Report for EP App. No. 12160352, completed Apr. 17, 2012.
Extended European Search Report for EP App. No. 12160352.6, dated May 2, 2012.
Indian Pre Grant Opposition Brief in Application No. 2423/CHENP/2011, dated Apr. 25, 2019, 35 pages (Exhibits excluded).
International Preliminary Report in International Application No. PCT/EP2009/063075, dated Nov. 4, 2010, 8 pages.
International Preliminary Report on Patentability for corresponding PCT application No. PCT/EP2009/063075.
International Search Report and Written Opinion in International Application No. PCT/EP2009/063075, dated Jan. 25, 2010, 9 pages.
International Search Report for corresponding PCT application No. PCT/EP2009/063075.
Japanese Office Action for JP App. No. 2011-530486, dated Oct. 8, 2013.
New Zealand Examination Report for NZ App. No. 592172, dated Apr. 16, 2012.
Russian Decision on Grant for RU App. No. 2011119019, dated Aug. 19, 2014.
Russian Office Action for RU App. No. 2011119019, dated Aug. 23, 2013.
Singapore Written Opinion and Search Report for SG App. No. 201102565-7, dated Apr. 18, 2013.
Taiwan Search Report for TW Patent Application No. 098134224, dated Jan. 23, 2015.
Wikipedia [online], "Washer (hardware", Aug. 21, 2004, [retrieved on Sep. 30, 2015], retrieved from: URL< https://en.wikipedia.org/wiki/Washer_(hardware)>, 7 pages.
Wikipedia, Washer (hardware) [online] [retrieved on Sep. 30, 2015]; Retrieved from the Internet: <URL:https://en.wikipedia.org/wiki/Washer_(hardware).
Wilhelm Becker, "Technical springs and punched and bent parts", 2007, 20 pages (with English Translation).

Also Published As

Publication number Publication date
NZ592172A (en) 2013-04-26
CA2740331C (en) 2017-08-01
RU2534610C2 (en) 2014-11-27
PT2346552E (en) 2012-11-06
TW201019980A (en) 2010-06-01
BRPI0920191B1 (en) 2019-10-08
EP2346552B1 (en) 2012-08-15
BRPI0920191A2 (en) 2015-12-29
TWI636809B (en) 2018-10-01
RU2011119019A (en) 2012-11-20
KR101677065B1 (en) 2016-11-29
ES2434771T3 (en) 2013-12-17
CA2740331A1 (en) 2010-04-22
AU2009304105B2 (en) 2011-12-08
US20120191049A1 (en) 2012-07-26
PT2468344E (en) 2013-10-14
BR122019007473B1 (en) 2020-11-17
US20110306939A1 (en) 2011-12-15
DE202009019078U1 (en) 2016-04-12
WO2010043533A1 (en) 2010-04-22
US9132237B2 (en) 2015-09-15
HK1160804A1 (en) 2012-08-17
US9078970B2 (en) 2015-07-14
BR122019007473B8 (en) 2021-06-22
IL212255A0 (en) 2011-06-30
ES2393173T3 (en) 2012-12-19
EP2468344A1 (en) 2012-06-27
CY1113363T1 (en) 2016-06-22
PL2468344T3 (en) 2013-12-31
CN102245235B (en) 2014-05-28
ES2393173T5 (en) 2020-06-26
DK2346552T4 (en) 2020-03-23
ZA201102541B (en) 2011-11-30
SI2468344T1 (en) 2013-12-31
IL212255A (en) 2014-01-30
TW201642921A (en) 2016-12-16
SI2346552T1 (en) 2012-12-31
EP2346552B2 (en) 2020-03-11
MY152436A (en) 2014-09-30
ES2393173T9 (en) 2020-07-14
JP5777518B2 (en) 2015-09-09
PL2346552T3 (en) 2013-01-31
MX2011003906A (en) 2011-04-28
JP2012504992A (en) 2012-03-01
SI2346552T2 (en) 2020-06-30
BRPI0920191B8 (en) 2021-06-22
CY1114549T1 (en) 2016-10-05
KR20110070895A (en) 2011-06-24
DK2468344T3 (en) 2013-12-09
EP2468344B1 (en) 2013-08-28
CN102245235A (en) 2011-11-16
EP2346552A1 (en) 2011-07-27
PL2346552T5 (en) 2020-04-30
DK2346552T3 (en) 2012-11-12
TWI601550B (en) 2017-10-11
AU2009304105A1 (en) 2010-04-22

Similar Documents

Publication Publication Date Title
USRE47614E1 (en) Drug delivery device and method of manufacturing a drug delivery device
US10561799B2 (en) Drive unit and injection device
EP3108914B1 (en) Injection device for delivering a defined number of equal doses of a liquid substance
DK2688616T3 (en) Drug delivery device
US8632507B2 (en) Auto-injector
US8702660B2 (en) Medicament delivery device
JP2020525104A (en) Torsion spring driven injection device
DK2734256T3 (en) PATTERN HOLDER FOR A PHARMACEUTICAL ADMINISTRATION DEVICE
CN109414549B (en) Drug delivery device comprising an adjustment member
JP2023506075A (en) Injection device for delivering liquid medication
US20210393885A1 (en) Dosing system for an injection device
CN108136127B (en) Setting mechanism for an injection device
CN114761055A (en) Injection device for delivering liquid medicament and method of assembly
CN114828923A (en) Injection device for delivering a predetermined plurality of predetermined dose volumes
JP2023502621A (en) variable dose syringe

Legal Events

Date Code Title Description
AS Assignment

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, GERMANY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HARMS, MICHAEL;RAAB, STEFFEN;REEL/FRAME:037994/0081

Effective date: 20110428

IPR Aia trial proceeding filed before the patent and appeal board: inter partes review

Free format text: TRIAL NO: IPR2019-01657

Opponent name: MYLAN PHARMACEUTICALS INC.,MYLAN INC., ANDMYLAN GM

Effective date: 20191007

Free format text: TRIAL NO: IPR2019-01658

Opponent name: MYLAN PHARMACEUTICALS INC.,MYLAN INC., ANDMYLAN GM

Effective date: 20191007

CC Certificate of correction
MAFP Maintenance fee payment

Free format text: PAYMENT OF MAINTENANCE FEE, 8TH YEAR, LARGE ENTITY (ORIGINAL EVENT CODE: M1552); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

Year of fee payment: 8