USRE46721E1 - Method and device for the metered dispensing of a medium - Google Patents

Method and device for the metered dispensing of a medium Download PDF

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Publication number
USRE46721E1
USRE46721E1 US15/261,070 US200815261070A USRE46721E US RE46721 E1 USRE46721 E1 US RE46721E1 US 200815261070 A US200815261070 A US 200815261070A US RE46721 E USRE46721 E US RE46721E
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US
United States
Prior art keywords
plunger
metering housing
metering
dosing
housing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
US15/261,070
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English (en)
Inventor
Eric Schliemann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stevanato Germany GmbH
Original Assignee
Stevanato Germany GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stevanato Germany GmbH filed Critical Stevanato Germany GmbH
Priority to US15/261,070 priority Critical patent/USRE46721E1/en
Application granted granted Critical
Publication of USRE46721E1 publication Critical patent/USRE46721E1/en
Active legal-status Critical Current
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0224—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type having mechanical means to set stroke length, e.g. movable stops
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31591—Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs

Definitions

  • the invention relates to a method for the metered dispensing of a medium from a container by means of a dosing pipette for removing a precisely predetermined amount of the medium, wherein the predetermined amount is set on the dosing pipette prior to removal.
  • a medium in particular liquid
  • a pipette is known for this, said pipette being inserted into the container and the medium being sucked into a small tube by pressing and releasing a rubber element. In this case, it is not possible to meter the medium to be removed.
  • WO2004/054720 makes known a metering device for sucking up and dispensing a free-flowing medium from a container, said device having an inlet and an outlet, and inlet and outlet are disposed separated from one another and a metering and displacement chamber is provided between them. Both inlet and outlet are sealable.
  • said metering device is a permanent component of the container itself and cannot be handled separately from said container.
  • WO 00/18453 also makes known a metering device.
  • said device also includes a container and it is only possible to use said devices in combination with one another.
  • a wheel that is situated above the container closure can be rotated to set the desired amount.
  • the long-term use of the device is to be improved and faulty dosings avoided.
  • the object is achieved in that an opening in the container or a container closure is sealed with a removable sealing plug prior to the insertion of the dosing pipette by the sealing plug being inserted into the container closure from the inside and through the insertion of the dosing pipette being ejected into the interior of the container.
  • the amount of the medium removed corresponds precisely to the wishes of the user, who can also alter the amount removed, if desired.
  • the container is a sealed bag, for example, the dosing pipette directly penetrates said bag.
  • the container should be a bottle or similar that is provided with a container closure. In this case, it may be advisable to provide the container closure with an opening into which the pipette can be inserted.
  • said opening Prior to the first insertion of the dosing pipette, said opening should be provided with a sealing plug so that the medium present in the container is not contaminated.
  • said sealing plug is moved out of its sealing position, remaining, in one exemplary embodiment of the invention, connected to the container closure by means of a securing ring. In this case, the sealing plug can be moved back into the closed position if the container closure is to be used for another bottle.
  • the sealing plug is inserted into the opening in a detachable manner. It is expelled into the interior of the container by the dosing pipette. If it is of sufficient weight, said sealing plug can then also be used as a mixing element for the medium, if the container has to be shaken before use, for example.
  • a dosing pipette according to the invention comprises only three elements that are preferably produced from plastics material.
  • the first is a metering housing, into which a plunger, the second, is inserted, which, in its turn, is limited in its stroke movement relative to the metering housing by the third element, namely a cam.
  • the metering housing is preferably a small elongate, cylindrical tube which, where applicable, tapers downwards and there surrounds an intake opening.
  • said tube Towards the top, said tube is somewhat widened and, in an exemplary embodiment, accommodates a stop ring, from which a cam projects inwards into the clearance of an axial recess of the tube, in which axial recess the plunger is also guided.
  • Said stop ring can be inserted into a corresponding annular recess in the widening and is engaged over towards the top by a flanged edge of the metering housing.
  • Other possibilities for securing the stop ring in the housing are also conceivable here.
  • the cam is a separate element that is inserted into the metering housing into a radial guide. Additional guide rails to facilitate the insertion of the cam can also be provided in said radial recess.
  • a web is situated in the radial recess, said web being traversed by the cam during insertion and snapping-in behind the cam to prevent the cam sliding out of the recess.
  • the plunger in its turn, has a neck region with a smaller diameter than that of a plunger outer surface. Said diameter is selected such that the neck can slide past the cam when the plunger is rotated. Said diameter then continues in grooves which are integrally formed in the plunger outer surface. I.e. the cam can slide in said grooves but at the same time forms an anti-twist protection here such that when the cam engages the grooves, only an axial movement of the plunger relative to the metering housing is possible. So that it is easier for the cam to find the groove associated with it, said groove has a conical groove inlet.
  • a plurality of grooves is integrally formed in the plunger outer surface distributed about the axis. Said grooves have different lengths so that they also allow for a different stroke of the plunger relative to the metering housing. Said stroke then determines the metering amount that is sucked into a metering space.
  • Said metering space is formed by an end journal of the plunger, an annular lip of the plunger surrounding said end journal and the metering housing and expands during the axial movement of the plunger relative to the metering housing.
  • the setting of the metering amount is effected by rotating the plunger about the axis as soon as the cam is in the region of the neck of the plunger.
  • markings are provided on a flange of the metering housing, it being possible to determine said markings with an indicator on the plunger. For the user this represents very simple handling, preventing faulty dosing.
  • the entire structure of the dosing pipette is very sturdy, simple and inexpensive to produce.
  • the entire pipette and the materials used in its production are consumer-friendly in accordance with the guidelines for the pharmaceutical industry and permit clean handling.
  • FIG. 1 shows a longitudinal section through a dosing pipette according to the invention
  • FIG. 2 shows a top view of the dosing pipette in FIG. 1 ;
  • FIG. 3 shows an outline of a plunger of the dosing pipette in FIG. 1 ;
  • FIG. 4 shows a cross section through the plunger in FIG. 3 along the line IV-IV;
  • FIG. 5 shows an enlarged cross section through the dosing pipette in FIG. 1 along the line V-V;
  • FIG. 6 shows a longitudinal section through another exemplary embodiment of a dosing pipette
  • FIG. 7 shows an exploded representation of an enlarged part region of the dosing pipette in FIG. 6 ;
  • FIG. 8 shows a schematically represented cross section through the dosing pipette in the part region in FIG. 7 ;
  • FIG. 9 shows a longitudinal section through a container closure according to the invention.
  • FIG. 10 shows a longitudinal section through the container closure in FIG. 9 with the dosing pipette inserted in the position of use;
  • FIG. 11 shows a longitudinal section through another exemplary embodiment of a container closure with the dosing pipette being inserted.
  • a dosing pipette P 1 has a metering housing 1 , into which a plunger 2 is inserted.
  • the plunger 2 sits in an axial recess 3 of the metering housing 1 and is rotatable in said axial recess 3 and displaceable along an axis A.
  • the plunger 2 has a plunger outer surface 4 , in which a plurality of grooves 5 . 1 to 5 . 4 is integrally formed.
  • Each of said grooves 5 . 1 to 5 . 4 has a groove inlet 6 that is conical.
  • the plunger outer surface 4 forms a step 7 towards the top, a neck 8 connecting to said step, a diameter d of the neck 8 being smaller than a diameter d 1 of the plunger 2 in the region of the plunger outer surface 4 .
  • a disc 9 with a lug 10 is placed onto said neck 8 .
  • Said disc 9 can be in the form of a head in an arbitrary manner and can be placed on the neck 8 or integrally formed with said neck.
  • annular lip 11 connects to the plunger outer surface 4 , said annular lip widening outwards in a conical manner. In so doing it partially surrounds an end journal 12 .
  • the metering housing 1 tapers towards the bottom and there surrounds an intake opening 13 .
  • the plunger 2 sits with its end journal 12 in said intake opening 13 .
  • the annular lip 11 abuts sealingly against the axial recess 3 and thus forms, together with the metering housing 1 and the end journal 12 , a metering space 14 , which expands as the plunger 2 moves along the axis A.
  • the dosing pipette is conceived as an ointment applicator, spherical geometry can be used so that no injuries are caused.
  • the end journal 12 can also be provided with an external thread so that it can be screw-connected into a corresponding internal thread of a container.
  • An external thread of this type can also be used, for example, to screw-connect a spherical region which, as mentioned above, avoids injuries.
  • a stop ring 16 is engaged in a housing widening 15 of the metering housing 1 and is retained by a flanged edge 17 .
  • a cam 18 projects from said stop ring 16 , as shown in FIG. 5 , into the clearance of the axial recess 3 of the metering housing 1 , said cam, in the position of use, engaging one of the grooves 5 . 1 to 5 . 4 of the plunger 2 .
  • Markings 20 which contain information concerning the metering amount, are situated on a housing flange 19 . Said metering amount depends on a stroke h that is indicated in FIG. 6 .
  • a container (not shown in any more detail), for example for a medical liquid, is sealed by a container closure 21 .
  • This can be a screw-type closure for example.
  • An insert 22 which is preferably produced from a softer plastics material than the container closure 21 , is situated in the container closure 21 .
  • An opening 23 which is preferably provided with capillaries 24 , is integrally formed in said insert 22 .
  • a closure plug 25 which is connected to the insert 22 in a captive manner by means of a securing ring 26 , sits in the opening 23 .
  • the dosing pipette P 1 To remove a predetermined amount of medium from the container, the dosing pipette P 1 , as shown in FIG. 10 , penetrates the opening 23 , beforehand or afterwards the lug 10 of the plunger 2 having been set to the desired marking determining the metering volume.
  • the sealing plug 25 When the dosing pipette P 1 is inserted into the opening 23 , the sealing plug 25 is ejected and remains suspended in the interior of the container closure 21 , as shown in FIG. 10 .
  • the container together with the container closure and the dosing pipette is then turned upside down and the plunger 2 is moved in the direction of the axis A in the axial recess 3 , the medium present in the container thereby being sucked into the metering space 14 in a desired metering volume.
  • the cam 18 moves along the predetermined groove 5 . 1 to 5 . 4 until it abuts against the bottom 27 of a groove. This limits its stroke h, which at the same time means that the desired amount of medium is situated in the metering space 14 .
  • the pipette is then pulled out of the opening 23 and, to discharge the medium from the metering space 14 , the plunger 2 is moved in the opposite direction along the axis A, the volume of the metering space 14 thereby being reduced.
  • the annular lip 11 seals off the metering space 14 so that the entire medium can be discharged through the intake opening 13 .
  • the end journal 12 engages the intake opening 13 and seals the same hermetically relative to the outside so that bacterial contamination in the system is excluded.
  • the plunger 2 is rotated about the axis A and the lug 10 is set to the desired marking 20 .
  • the cam 18 then runs down a different groove 5 . 1 to 5 . 4 that has a different length and corresponds to the desired metering volume.
  • FIG. 11 shows that it is also possible for a sealing plug 25 . 1 to be disposed in a detachable manner in the opening 23 .
  • the sealing plug 25 . 1 falls into the interior of the container, as shown by the dot dash line, and can be used there to mix up the medium when the container is shaken.
  • a dosing pipette P 2 differs from the dosing pipette P 1 in that the cam is not part of a stop ring, but is a separate element.
  • Said cam 18 . 1 is inserted laterally in a radial manner into a recess 28 in a metering housing 1 . 1 , it being possible for said inserting to be supported by corresponding guide rails (not shown).
  • a web 29 is formed in the recess 28 for the cam 18 . 1 , said web, in the end position of the cam 18 . 1 where said cam, as shown in FIG. 6 , abuts against the metering housing 1 .

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
US15/261,070 2007-03-22 2008-03-25 Method and device for the metered dispensing of a medium Active 2031-02-22 USRE46721E1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US15/261,070 USRE46721E1 (en) 2007-03-22 2008-03-25 Method and device for the metered dispensing of a medium

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE102007014418A DE102007014418A1 (de) 2007-03-22 2007-03-22 Verfahren und Vorrichtung zum dosierten Ausbringen eines Mediums
DE102007014418 2007-03-22
US15/261,070 USRE46721E1 (en) 2007-03-22 2008-03-25 Method and device for the metered dispensing of a medium
US12/532,516 US8826750B2 (en) 2007-03-22 2008-03-25 Method and device for the metered dispensing of a medium
PCT/EP2008/002344 WO2008113611A1 (de) 2007-03-22 2008-03-25 Verfahren und vorrichtung zum dosierten ausbringen eines mediums

Publications (1)

Publication Number Publication Date
USRE46721E1 true USRE46721E1 (en) 2018-02-20

Family

ID=39672569

Family Applications (2)

Application Number Title Priority Date Filing Date
US12/532,516 Ceased US8826750B2 (en) 2007-03-22 2008-03-25 Method and device for the metered dispensing of a medium
US15/261,070 Active 2031-02-22 USRE46721E1 (en) 2007-03-22 2008-03-25 Method and device for the metered dispensing of a medium

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US12/532,516 Ceased US8826750B2 (en) 2007-03-22 2008-03-25 Method and device for the metered dispensing of a medium

Country Status (5)

Country Link
US (2) US8826750B2 (de)
EP (1) EP2129465B1 (de)
AT (1) ATE518593T1 (de)
DE (1) DE102007014418A1 (de)
WO (1) WO2008113611A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103260759B (zh) 2010-12-21 2016-05-18 通用电气医疗集团英国有限公司 过滤装置和方法
DE102011055888A1 (de) 2011-02-15 2012-08-16 Slg Pharma Gmbh & Co. Kg Vorrichtung zur dosierten Ausbringung eines Mediums
AU2013202805B2 (en) * 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
FR3038518A1 (fr) * 2015-07-08 2017-01-13 Guerbet Sa Seringue et son procede d'assemblage

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3101751A (en) 1959-09-08 1963-08-27 Dosamatic Dropper Corp Liquid dropper assembly
US3672369A (en) 1969-12-18 1972-06-27 Sherwood Medical Ind Inc Hypodermic syringe
DE2533036A1 (de) 1975-07-24 1977-02-10 Merck Patent Gmbh Zweikammerspritze
US4084739A (en) * 1977-02-28 1978-04-18 Wisconsin Centrifugal, Inc. Apparatus and method for aligning and welding tubular metal components together
FR2493515A1 (fr) 1980-10-31 1982-05-07 Suppo Steril Laboratoires Dispositif de reglage et de blocage de la course d'un piston
EP0117489A2 (de) 1983-02-28 1984-09-05 Abbott Laboratories Zweikammerbehälter
EP0250095A2 (de) 1986-06-18 1987-12-23 Jencons (Scientific) Limited Flüssigkeitsabgabevorrichtung
US5983733A (en) * 1996-11-15 1999-11-16 Hamilton Company Manual pipette
WO2000018453A1 (en) 1998-09-30 2000-04-06 Comar, Inc. Exact dose dispenser device assembly
WO2004054720A1 (de) 2002-12-17 2004-07-01 Eric Schliemann Dosiervorrichtung
WO2005087127A1 (en) 2004-02-13 2005-09-22 Paradis Joeseph R Swabbable needleless vial access

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3101751A (en) 1959-09-08 1963-08-27 Dosamatic Dropper Corp Liquid dropper assembly
US3672369A (en) 1969-12-18 1972-06-27 Sherwood Medical Ind Inc Hypodermic syringe
DE2533036A1 (de) 1975-07-24 1977-02-10 Merck Patent Gmbh Zweikammerspritze
US4048999A (en) 1975-07-24 1977-09-20 Merck Patent Gesellschaft Mit Beschrankter Haftung Two-chamber mixing syringe
US4084739A (en) * 1977-02-28 1978-04-18 Wisconsin Centrifugal, Inc. Apparatus and method for aligning and welding tubular metal components together
FR2493515A1 (fr) 1980-10-31 1982-05-07 Suppo Steril Laboratoires Dispositif de reglage et de blocage de la course d'un piston
EP0117489A2 (de) 1983-02-28 1984-09-05 Abbott Laboratories Zweikammerbehälter
US4614267A (en) 1983-02-28 1986-09-30 Abbott Laboratories Dual compartmented container
EP0250095A2 (de) 1986-06-18 1987-12-23 Jencons (Scientific) Limited Flüssigkeitsabgabevorrichtung
US5983733A (en) * 1996-11-15 1999-11-16 Hamilton Company Manual pipette
WO2000018453A1 (en) 1998-09-30 2000-04-06 Comar, Inc. Exact dose dispenser device assembly
WO2004054720A1 (de) 2002-12-17 2004-07-01 Eric Schliemann Dosiervorrichtung
US20080041894A1 (en) 2002-12-17 2008-02-21 Eric Schliemann Dosing Device
WO2005087127A1 (en) 2004-02-13 2005-09-22 Paradis Joeseph R Swabbable needleless vial access

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Partial English Translation of FR 2493515 A1 to Chollet Michel De. *

Also Published As

Publication number Publication date
WO2008113611A1 (de) 2008-09-25
EP2129465A1 (de) 2009-12-09
DE102007014418A1 (de) 2008-09-25
US8826750B2 (en) 2014-09-09
US20100089185A1 (en) 2010-04-15
EP2129465B1 (de) 2011-08-03
ATE518593T1 (de) 2011-08-15

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