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USRE43258E1 - Glue for cartilage repair - Google Patents

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USRE43258E1
USRE43258E1 US12966674 US96667410A USRE43258E US RE43258 E1 USRE43258 E1 US RE43258E1 US 12966674 US12966674 US 12966674 US 96667410 A US96667410 A US 96667410A US RE43258 E USRE43258 E US RE43258E
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cartilage
defect
allograft
material
pieces
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Katherine G. Truncale
Moon Hae Sunwoo
Arthur A. Gertzman
William W. Tomford
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Musculoskeletal Transplant Foundation
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Musculoskeletal Transplant Foundation
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Abstract

The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers with allogenic chondrocytes or bone marrow cells in an amount exceeding the natural occurrence of same in hyaline cartilage and adding a cell growth additive.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

More than one reissue application has been filed for the reissue of U.S. Pat. No. 7,067,123, issued Jun. 27, 2006, said reissue applications being U.S. application Ser. No. Re. 12/147,042, filed Jun. 26, 2008, now U.S. Pat. No. Re. 42,208, and the present application, which is a continuation reissue application of U.S. application Ser. No. Re. 12/147,042.

RELATED APPLICATIONS

There is no related application.

1. Field of Invention

The present invention is generally directed toward an implant and is more specifically directed toward a paste or gel implant material for a cartilage defect.

2. Background of the Invention

Articular cartilage injury and degeneration present medical problems to the general population which are addressed by orthopedic surgeons. Every year in the United States, over 500,000 arthroplastic or joint repair procedures are performed. These include approximately 125,000 total hip and 150,000 total knee arthroplastics and over 41,000 open arthroscopic procedures to repair cartilaginous defects of the knee.

In the knee joint, the articular cartilage tissue forms a lining which faces the joint cavity on one side and is linked to the subchondral bone plate by a narrow layer of calcified cartilage tissue on the other. Articular cartilage (hyaline cartilage) consists primarily of extracellular matrix with a sparse population of chondrocytes distributed throughout the tissue. Articular cartilage is composed of chondrocytes, type II collagen fibril network, proteoglycans and water. Active chondrocytes are unique in that they have a relatively low turnover rate and are sparsely distributed within the surrounding matrix. The collagens give the tissue its form and tensile strength and the interaction of proteoglycans with water give the tissue its stiffniess to compression, resilience and durability. The hyaline cartilage provides a low friction bearing surface over the bony parts of the joint. If the lining becomes worn or damaged resulting in lesions, joint movement may be painful or severely restricted. Whereas damaged bone typically can regenerate successfully, hyaline cartilage regeneration is quite limited because of it's limited regenerative and reparative abilities.

Articular cartilage lesions generally do not heal, or heal only partially under certain biological conditions due to the lack of nerves, blood vessels and a lymphatic system. The limited reparative capabilities of hyaline cartilage usually results in the generation of repair tissue that lacks the structure and biomechanical properties of normal cartilage. Generally, the healing of the defect results in a fibrocartilaginous repair tissue that lacks the structure and biomedical properties of hyaline cartilage and degrades over the course of time. Articular cartilage lesions are frequently associated with disability and with symptoms such as joint pain, locking phenomena and reduced or disturbed function. These lesions are difficult to treat because of the distinctive structure and function of hyaline cartilage. Such lesions are believed to progress to severe forms of osteoarthritis. Osteoarthritis is the leading cause of disability and impairment in middle-aged and older individuals, entailing significant economic, social and psychological costs. Each year, osteoarthritis accounts for as many as 39 million physician visits and more than 500,000 hospitalizations. By the year 2020, arthritis is expected to affect almost 60 million persons in the United States and to limit the activity of 11.6 million persons.

There are many current therapeutic methods being used. None of these therapies has resulted in the successful regeneration of hyaline-like tissue that withstands normal joint loading and activity over prolonged periods. Currently, the techniques most widely utilized clinically for cartilage defects and degeneration are not articular cartilage substitution procedures, but rather lavage, arthroscopic debridement, and repair stimulation. The direct transplantation of cells or tissue into a defect and the replacement of the defect with biologic or synthetic substitutions presently accounts for only a small percentage of surgical interventions. The optimum surgical goal is to replace the defects with cartilage-like substitutes so as to provide pain relief, reduce effusions and inflammation, restore function, reduce disability and postpone or alleviate the need for prosthetic replacement.

Lavage and arthroscopic debridement involve irrigation of the joint with solutions of sodium chloride, Ringer or Ringer and lactate. The temporary pain relief is believed to result from removing degenerative cartilage debris, proteolytic enzymes and inflammatory mediators. These techniques provide temporary pain relief, but have little or no potential for further healing.

Repair stimulation is conducted by means of drilling, abrasion arthroplasty or microfracture. Penetration into the subchondral bone induces bleeding and fibrin clot formation which promotes initial repair, however, the tissue formed is fibrous in nature and not durable. Pain relief is temporary as the tissue exhibits degeneration, loss of resilience, stiffness and wear characteristics over time.

The periosteum and perichondrium have been shown to contain mesenchymal progenitor cells capable of differentiation and proliferation. They have been used as grafts in both animal and human models to repair articular defects. Few patients over 40 years of age have obtained good clinical results, which most likely reflects the decreasing population of osteochondral progenitor cells with increasing age. There have also been problems with adhesion and stability of the grafts, which result in their displacement or loss from the repair site.

Transplantation of cells grown in culture provides another method of introducing a new cell population into chondral and osteochondral defects. Carticel® is a commercial process to culture a patient's own cartilage cells for use in the repair of cartilage defects in the femoral condyle marketed by Genzyme Biosurgery in the United States and Europe. The procedure uses arthroscopy to take a biopsy from a healthy, less loaded area of articular cartilage. Enzymatic digestion of the harvested tissue releases the cells that are sent to a laboratory where they are grown for a period ranging from 2-5 weeks. Once cultivated, the cells are injected during a more open and extensive knee procedure into areas of defective cartilage where it is hoped that they will facilitate the repair of damaged tissue. An autologous periosteal flap with cambium layer is used to seal the transplanted cells in place and act as a mechanical barrier. Fibrin glue is used to seal the edges of the flap. This technique preserves the subchondral bone plate and has reported a high success rate. Proponents of this procedure report that it produces satisfactory results, including the ability to return to demanding physical activities, in more than 90% of patients and that biopsy specimens of the tissue in the graft sites show hyaline-like cartilage repair. More work is needed to assess the function and durability of the new tissue and determine whether it improves joint function and delays or prevents joint degeneration. As with the perichondrial graft, patient/donor age may compromise the success of this procedure as chondrocyte population decreases with increasing age. Disadvantages to this procedure include the need for two separate surgical procedures, potential damage to surrounding cartilage when the periosteal patch is sutured in place, the requirement of demanding microsurgical techniques, and the expensive cost of the procedure which is currently not covered by insurance.

Osteochondral transplantation or mosaicplasty involves excising all injured or unstable tissue from the articular defect and creating cylindrical holes in the base of the defect and underlying bone. These holes are filled with autologous cylindrical plugs of healthy cartilage and bone in a mosaic fashion. The osteochondral plugs are harvested from a lower weight-bearing area of lesser importance in the same joint. This technique, shown in Prior Art FIG. 2, can be performed as arthroscopic or open procedures. Reports of results of osteochondral plug autografts in a small number of patients indicate that they decrease pain and improve joint function, however, long-term results have not been reported. Factors that can compromise the results include donor site morbidity, effects of joint incongruity on the opposing surface of the donor site, damage to the chondrocytes at the articular margins of the donor and recipient sites during preparation and implantation, and collapse or settling of the graft over time. The limited availability of sites for harvest of osteochondral autografts restricts the use of this approach to treatment of relatively small articular defects and the healing of the chondral portion of the autograft to the adjacent articular cartilage remains a concern.

Transplantation of large allografts of bone and overlying articular cartilage is another treatment option that involves a greater area than is suitable for autologous cylindrical plugs, as well as for a non-contained defect. The advantages of osteochondral allografts are the potential to restore the anatomic contour of the joint, lack of morbidity related to graft harvesting, greater availability than autografts and the ability to prepare allografts in any size to reconstruct large defects. Clinical experience with fresh and frozen osteochondral allografts shows that these grafts can decrease joint pain, and that the osseous portion of an allograft can heal to the host bone and the chondral portion can function as an articular surface. Drawbacks associated with this methodology in the clinical situation include the scarcity of fresh donor material and problems connected with the handling and storage of frozen tissue. Fresh allografts carry the risk of immune response or disease transmission. Musculoskeletal Transplant Foundation (MTF) has preserved fresh allografts in a media that maintains a cell viability of 50% for 35 days for use as implants. Frozen allografts lack cell viability and have shown a decreased amount of proteoglycan content which contribute to deterioration of the tissue.

A number of patents in the prior art show the use of bone putty, pastes or gels to fill bone defects. U.S. Pat. No. 5,290,558 issued Mar. 1, 1994 discloses a flowable demineralized bone powder composition using an osteogenic bone powder with large particle size ranging from about 0.1 to about 1.2 cm. mixed with a low molecular weight polyhydroxy compound possessing from 2 to about 18 carbons including a number of classes of different compounds such as monosaccharides, disaccharides, water dispersible oligosaccharides and polysaccharides.

A bone gel is disclosed in the U.S. Pat. No. 5,073,373 issued Dec. 17, 1991. Bone lamellae in the shape of threads or filaments retaining low molecular weight glycerol carrier are disclosed in U.S. Pat. Nos. 5,314,476 issued May 24, 1994 and 5,507,813 issued Apr. 16, 1996 and the tissue forms described in these patents are known commercially as the GRAFTON® Putty and Flex, respectively.

U.S. Pat. No. 5,356,629 issued Oct. 18, 1994 discloses making a rigid gel in the nature of a bone cement to fill defects in bone by mixing biocompatible particles, preferably polymethylmethacrylate coated with polyhydroxyethylmethacrylate in a matrix selected from a group which lists hyaluronic acid to obtain a molded semi-solid mass which can be suitably worked for implantation into bone. The hyaluronic acid can also be utilized in monomeric form or in polymeric form preferably having a molecular weight not greater than about one million Daltons. It is noted that the nonbioabsorbable material which can be used to form the biocompatible particles can be derived from xenograft bone, homologous bone, autogenous bone as well as other materials. The bioactive substance can also be an osteogenic agent such as demineralized bone powder, morselized cancellous bone, aspirated bone marrow and other autogenous bone sources. The average size of the particles employed is preferably about 0.1 to about 3.0 mm, more preferably about 0.2 to about 1.5 mm, and most preferably about 0.3 to about 1.0 mm. It is inferentially mentioned but not taught that particles having average sizes of about 7,000 to 8,000 microns, or even as small as about 100 to 700 microns can be used.

U.S. Pat. No. 4,172,128 issued Oct. 23, 1979 discloses a demineralized bone material mixed with a carrier to reconstruct tooth or bone material by adding a mucopolysaccharide to a mineralized bone colloidal material. The composition is formed from a demineralized coarsely ground bone material, which may be derived from human bones and teeth, dissolved in a solvent forming a colloidal solution to which is added a physiologically inert polyhydroxy compound such as mucopolysaccharide or polyuronic acid in an amount which causes orientation when hydrogen ions or polyvalent metal ions are added to form a gel. The gel will be flowable at elevated temperatures above 35° C. and will solidify when brought down to body temperature. Example 25 of the patent notes that mucopolysaccharides produce pronounced ionotropic effects and that hyaluronic acid is particularly responsible for spatial cross-linking.

U.S. Pat. No. 6,030,635 issued Feb. 29, 2000 and U.S. Pat. No. 6,437,018 issued Aug. 20, 2002 are directed toward a malleable bone putty and a flowable gel composition for application to a bone defect site to promote new bone growth at the site which utilize a new bone growth inducing compound of demineralized lyophilized allograft bone powder. The bone powder has a particle size ranging from about 100 to about 850 microns and is mixed in a high molecular weight hydrogel carrier which contains a sodium phosphate saline buffer.

The use of implants for cartilage defects is much more limited. Aside from the fresh allograft implants and autologous implants, U.S. Pat. No. 6,110,209 issued Nov. 5, 1998 shows the use an autologous articular cartilage cancerous bone paste to fill arthritic defects. The surgical technique is arthroscopic and includes debriding (shaving away loose or fragmented articular cartilage), followed by morselizing the base of the arthritic defect with an awl until bleeding occurs. An osteochondral graft is then harvested from the inner rim of the intercondylar notch using a trephine. The graft is then morselized in a bone graft crusher, mixing the articular cartilage with the cancellous bone. The paste is then pushed into the defect and secured by the adhesive properties of the bleeding bone. The paste can also be mixed with a cartilage stimulating factor, a plurality of cells, or a biological glue. All patients are kept non-weight bearing for four weeks and used a continuous passive motion machine for six hours each night. Histologic appearance of the biopsies have mainly shown a mixture of fibrocartilage with hyaline cartilage. Concerns associated with this method are harvest site morbidity and availability, similar to the mosaicplasty method.

SUMMARY OF THE INVENTION

A cartilage implant material in paste or gel form for repairing articular cartilage defects is composed of milled allograft cartilage pieces in a bioabsorbable carrier. Autologous chondrocyte in an amount exceeding the number naturally occurring in hyaline cartilage for a mature adult between 20 and 55 years of age may also be applied to the matrix. Additives may be applied to the mixture in order to increase chondrocyte migration and proliferation. The implant material can support the addition of a variety of chondrogenic stimulating factors including, but not limited to growth factors (FGF-2, FGF-5, IGF-1, TGF-β, BMP-2, BMP-7, PDGF, VEGF), human allogenic or autologous chondrocytes, human allogenic or autologous bone marrow cells, stem cells, demineralized bone matrix, insulin, insulin-like growth factor-1, transforming growth factor-B, interleukin-1 receptor antagonist, hepatocyte growth factor, platelet-derived growth factor, Indian hedgehog and parathyroid hormone-related peptide or bioactive glue.

The implant material is placed in the lesion area and may be sealed with a periosteum cap.

It is an object of the invention to provide an allograft implant material for joints which provides pain relief, restores normal function and will postpone or alleviate the need for prosthetic replacement.

It is also an object of the invention to provide a cartilage repair implant material which is easily placed in a defect area by the surgeon using an arthroscopic, minimally invasive technique.

It is further an object of the invention to provide an allograft implant material procedure which is applicable for both partial and full thickness lesions.

It is yet another object of the invention to provide an allograft implant material which facilitates growth of hyaline cartilage.

It is an additional object of the invention to provide implant paste and gel material formulations that satisfy surgical requirements and are made from donated human available allograft tissue, some of which would otherwise be considered waste and thrown away.

These and other objects, advantages, and novel features of the present invention will become apparent when considered with the teachings contained in the detailed disclosure along with the accompanying drawings.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows the anatomy of a knee joint with a lesion;

FIG. 2 shows a schematic mosaicplasty as known in the prior art; and

FIG. 3 shows a schematic perspective view of cartilage defect material placed in a defect site with an exploded periosteum cap.

DESCRIPTION OF THE INVENTION

The terms “tissue” is used in the general sense herein to mean any transplantable or implantable tissue, the survivability of which is improved by the methods described herein upon implantation. In particular, the overall durability and longevity of the implant are improved, and host-immune system mediated responses, are substantially eliminated.

The terms “transplant” and “implant” are used interchangably to refer to tissue, material or cells (xenogeneic or allogeneic) which may be introduced into the body of a patient to replace or supplement the structure or function of the endogenous tissue.

The terms “autologous” and “autograft” refer to tissue or cells which originate with or are derived from the recipient, whereas the terms “allogeneic” and “allograft” refer to cells and tissue which originate with or are derived from a donor of the same species as the recipient. The terms “xenogeneic” and “xenograft” refer to cells or tissue which originates with or is derived from a species other than that of the recipient.

The term “gel” refers to a mixture of minced or milled pretreated allograft cartilage in a biocomposite carrier having a viscosity which is less than and is less rigid than a mixture of minced or milled pretreated allograft cartilage in a biocompatible carrier referred to by the terms “putty” or “paste” and contains less cartilage by weight than putty or paste.

The present invention is directed towards a cartilage repair material and method of treatment. The preferred embodiment and best mode of the invention is shown in FIG. 3. In the production of the invention, allograft hyaline cartilage is lyophilized reducing its water content and milled for ease in application.

After washes with sterile de-ionized (DI) water, the cartilage material was frozen at −20° to −100° C. preferably −70° C. and lyophilized to reduce the water content within the range of about 0.1% to about 8.0%. The cartilage is frozen with liquid nitrogen and ground into particles.

A lesion or defect is removed by cutting a bore 50 or trimming a lesion in the implant area 100 and filling the bore 50 or lesion area with a milled cartilage mixture 20 of paste or gel consisting together with a biological carrier such as hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran, or polymers and one or more additives namely chondrogenic stimulating factors including, but not limited to growth factors (FGF-2, FGF-5, IGF-1, TGF-β, BMP-2, BMP-7, PDGF, VEGF), human allogenic or autologous chondrocytes, human allogenic cells, human allogenic or autologous bone marrow cells, human allogenic or autologous stem cells, demineralized bone matrix, insulin, insulin-like growth factor-1, interleukin-1 receptor antagonist, hepatocyte growth factor, platelet-derived growth factor, Indian hedgehog and parathyroid hormone-related peptide.

Suitable organic glue material can be used to keep the viscous cartilage mixture 20 fixed in place in the implant area or to affix a periosteal cap 30 in place over the surrounding hyaline cartilage area 100. Suitable organic glue material can be found commercially, such as for example; TISSEEL® or TISSUCOL.®) (fibrin based adhesive; Immuno AG, Austria), Adhesive Protein (Sigma Chemical, USA), and Dow Corning Medical Adhesive B (Dow Corning, USA).

EXAMPLE 1

A matrix of minced cartilage putty consisting of minced or milled allograft articular cartilage which has been lyophilized so that its water content ranges from 0.1% to 8.0% with a cartilage content ranging from 25% to 50% by weight is mixed with a carrier of sodium hyaluronate solution (HA) (molecular weight ranging from 7.0×105 to 1.2×106) or any other bioabsorbable carrier such as hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran, or polymers, the carrier ranging from 75% to 50% by weight. The cartilage is milled to a size ranging from 0.01 mm to 1 mm. In gel form, the minced cartilage which has been lyophilized so that its water content ranges from 0.1% to 8.0% ranging from 15% to 30% by weight and the carrier ranges from 85% to 70% by weight. The particle size of the cartilage when milled is less than or equal to 1 mm dry in the previously stated range. The cartilage pieces can be processed to varying particle sizes and the HA or other carrier can have different viscosities depending on the desired consistency of the putty or paste. This cartilage matrix can be deposited into the cartilage defect arthroscopically and fit into the defect where it is held in place by it's own viscosity, mixed with fibrin glue or covered with a periosteal or perichondrial flap, then sealed with biological glue. As with the first two matrices, this matrix can support the previously mentioned chondrogenic factors.

EXAMPLE 2

A matrix of minced cartilage putty consisting of minced or milled allograft cartilage which has been lyophilized so that its water content ranges from 0.1% to 8.0% ranging from 25% to 50% by weight is mixed with a carrier of sodium hyaluronate solution (HA) (7.0×105 to 1.2×106) or any other bioabsorbable carrier such as hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran, or polymers ranging from 75% to 50% by weight. In a gel form, the minced cartilage which has been lyophilized so that its water content ranges from 0.01% to 8.0% ranging from 15% to 30% by weight and the carrier ranges from 85% to 70% by weight. The particle size of the cartilage is less than or equal to 1 mm dry ranging from 0.01 mm to 1 mm. The cartilage pieces can be processed to varying particle sizes and the HA or carrier can have different viscosities depending on the desired consistency of the putty or paste. Autologous or allogenic cells which have been grown outside the patient are inserted by syringe into the matrix before, during or after deposit of the cartilage matrix into the defect area. Such cells include allogenic or autologous bone marrow cells, stem cells and chondrocyte cells. The cellular density of the cells preferably ranges from about 1×108 to 5×108 or from about 100 million to about 500 million cells per cc of putty or gel mixture. This composite material can be injected into the cartilage defect arthroscopically and fit into the defect where it is held in place by it's own viscosity, or covered with a periosteal or perichondrial flap, then sealed with biological glue. As with the first matrix, this matrix can support the previously mentioned chondrogenic factors.

The operation of placing the cartilage composition in a cartilage defect, comprises (a) cutting a patient's tissue at a site of a cartilage defect to remove the diseased area of cartilage; (b) placing a mixture of milled allograft cartilage in a bioabsorbable carrier in the defect area; and (c) placing a periosteal cover over the mixture of the inserted milled allograft cartilage in a bioabsorbable carrier to contain the mixture in the defect area for a predetermined period of time to promote cartilage growth at the defect site. Alternate steps include the addition of growth factors, chondrocytes, bone marrow cells and stem cells.

The principles, preferred embodiments and modes of operation of the present invention have been described in the foregoing specification. However, the invention should not be construed as limited to the particular embodiments which have been described above. Instead, the embodiments described here should be regarded as illustrative rather than restrictive.

Claims (110)

What we claim is:
1. A sterile allograft cartilage defect implant material for use in human beings comprising milled allograft cartilage pieces sized less than 1 mm and lyophilized so that their water content ranges from about 0.1% to about 8.0% in a bioabsorbable carrier.
2. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said milled cartilage ranges from about 25% to about 50% by weight and said carrier ranges from about 75% to about 50% by weight.
3. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said milled cartilage ranges from about 15% to about 30% by weight with the carrier ranging from about 85% to about 70% by weight.
4. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said carrier is sodium hyaluronate and its derivatives.
5. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said implant material includes a protein glue.
6. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said implant material includes the addition of autologous chondrocytes to achieve a concentration exceeding the concentration of chondrocytes naturally occurring in the patient.
7. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said milled cartilage is hyaline cartilage.
8. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said milled cartilage is fibrosus cartilage.
9. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said milled cartilage is hyaline and fibrosus cartilage.
10. A sterile allograft cartilage defect implant material claimed in claim 1 including an additive to said implant material consisting of one or more of a group consisting of growth factors, human allogenic cells, human allogenic bone marrow cells, human autologous bone marrow cells, human allogenic stem cells, human autologous stem cells, human demineralized bone matrix, and insulin.
11. A sterile cartilage repair material as claimed in claim 10 wherein said growth factors are one or more of a group consisting of FGF-2, FGF-5, IGF-1, TGF-β, BMP-2, BMP-7, PDGF, VEGF.
12. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said carrier comprises one or more bioabsorbable carriers taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers.
13. A sterile cartilage defect implant material comprising milled allograft articular cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers and allogenic chondrocytes in an amount exceeding the natural occurrence of same in articular cartilage.
14. A sterile cartilage defect implant material as claimed in claim 13 wherein said allograft articular cartilage is hyaline cartilage.
15. A sterile allograft cartilage defect implant material as claimed in claim 13 wherein said milled cartilage is fibrous cartilage.
16. A sterile allograft cartilage defect implant material as claimed in claim 13 wherein said milled cartilage is hyaline and fibrous cartilage.
17. A sterile cartilage repair material as claimed in claim 13 wherein said implant material includes an additive consisting of one or more of a group consisting of growth factors, human allogenic cells, human allogenic bone marrow cells, human autologous bone marrow cells, human allogenic stem cells, human autologous stem cells, demineralized bone matrix, and insulin.
18. A sterile cartilage repair material as claimed in claim 17 wherein said growth factors are one or more of a group consisting of FGF-2, FGF-5, IGF-1, TGF-β, BMP-2, BMP-7, PDGF, VEGF.
19. A sterile cartilage defect implant material as claimed in claim 13 wherein said milled cartilage ranges from about 25% to about 50% by weight and said carrier ranges from about 75% to about 50% by weight.
20. A sterile cartilage defect implant material as claimed in claim 13 wherein said milled cartilage ranges from about 15% to about 30% by weight with the carrier ranging from about 85% to about 70% by weight.
21. A sterile cartilage defect implant material comprising lyophilized milled allograft articular cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers and autologous bone marrow cells in an amount exceeding the natural occurrence of same in a patient being treated.
22. A sterile cartilage defect repair material as claimed in claim 21 including an additive in said implant material which consists of one or more of a group consisting of growth factors, human allogenic cells, autologous chondrocytes, demineralized bone matrix, and insulin.
23. A sterile cartilage repair material as claimed in claim 22 wherein said growth factors are one or more of a group consisting of FGF-2, FGF-5, IGF-1, TGF-β, BMP-2, BMP-7, PDGF, VEGF.
24. A sterile cartilage defect repair material as claimed in claim 21 wherein said bioabsorbable carrier consists of sodium hyaluronate, hyaluronic acid and its derivatives.
25. A sterile cartilage defect material as claimed in claim 21 wherein said lyophilized cartilage pieces have a water content ranging from about 0.1% to 8.0%.
26. A sterile cartilage defect implant material as claimed in claim 21 wherein said allograft articular cartilage is hyaline cartilage.
27. A sterile allograft cartilage defect implant material as claimed in claim 21 wherein said milled cartilage is fibrous cartilage.
28. A sterile allograft cartilage defect implant material as claimed in claim 21 wherein said milled cartilage is hyaline and fibrous cartilage.
29. A sterile cartilage defect implant material as claimed in claim 21 wherein said milled cartilage ranges from about 25% to about 50% by weight and said carrier ranges from about 75% to about 50% by weight.
30. A sterile cartilage defect implant material as claimed in claim 21 wherein said milled cartilage ranges from about 15% to about 30% by weight with the carrier ranging from about 85% to about 70% by weight.
31. A sterile cartilage defect implant material comprising lyophilized milled allograft articular cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers and autologous stem cells in an amount exceeding the natural occurrence of same in a patient being treated.
32. A method of placing a cartilage defect material in a cartilage defect, said cartilage defect material comprising milled allograft articular cartilage which has been lyophilized and mixed in a bioabsorbable carrier comprising the steps of:
(a) cutting a patient's tissue at a site of a cartilage defect to remove a diseased area of cartilage;
(b) adding autologous cells to said mixture of milled allograft cartilage in a bioabsorbable carrier;
(c) placing a mixture of milled allograft cartilage with added autologous cells in a bioabsorbable carrier in the cartilage defect area where cartilage has been removed; and
(d) placing a cover over the mixture of milled allograft cartilage in a bioabsorbable carrier to contain the mixture in cartilage defect site for a predetermined period of time.
33. The method of claim 32 wherein growth factors are added to said mixture.
34. The method of claim 32 wherein said autologous cells are chondrocytes.
35. The method of claim 32 wherein said autologous cells are bone marrow cells.
36. The method of claim 32 wherein said autologous cells are stem cells.
37. A sterile cartilage defect implant material comprising lyophilized milled allograft articular cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives and chitosan and autologous chondrocytes in an amount exceeding the natural occurrence of same in articular cartilage, wherein said milled cartilage ranges from about 25% to about 50% by weight and said bioabsorbable carrier ranges from about 75% to about 50% by weight.
38. A sterile cartilage defect implant material comprising lyophilized milled allograft articular cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of gelatin, collagen and alginate and autologous chondrocytes in an amount exceeding the natural occurrence of same in articular cartilage, wherein said milled cartilage ranges from about 25% to about 50% by weight and said bioabsorbable carrier ranges from about 75% to about 50% by weight.
39. A sterile cartilage defect implant material comprising lyophilized milled allograft articular cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of buffered PBS, Dextran or polymers and autologous chondrocytes in an amount exceeding the natural occurrence of same in articular cartilage, wherein said milled cartilage ranges from about 25% to about 50% by weight and said bioabsorbable carrier ranges from about 75% to about 50% by weight.
40. A cartilage defect repair material for use in human beings, comprising a mixture having a bioabsorbable carrier and freeze-milled allograft cartilage pieces having a size not greater than 1 mm, said mixture being in the form of a gel.
41. A cartilage defect repair material for use in human beings, comprising a mixture having a bioabsorbable carrier and freeze-milled allograft cartilage pieces having a size not greater than 1 mm, said mixture being in the form of a paste, and said cartilage pieces being present in said mixture in an amount within the range of from about 25% to about 50% by weight.
42. A cartilage defect repair material for use in human beings, comprising a mixture having a bioabsorbable carrier and freeze-milled allograft cartilage pieces having a size not greater than 1 mm, said mixture being in the form of one of a paste and a gel, and said cartilage pieces being present in said mixture in an amount within the range of from about 15% to about 50% by weight.
43. A cartilage defect repair material as claimed in any one of claims 40, 41 and 42, wherein said cartilage pieces are formed from allograft cartilage having a reduced water content.
44. A cartilage defect repair material as claimed in any one of claims 40, 41 and 42, wherein said cartilage pieces are formed from allograft cartilage having a reduced water content within the range of about 0.1% to about 8.0% by weight.
45. A cartilage defect repair material as claimed in any one of claims 40, 41 and 42, wherein said cartilage pieces are formed from allograft cartilage that has been lyophilized so as to reduce its water content to an amount within the range of about 0.1% to about 8.0% by weight.
46. A cartilage defect repair material as claimed in any one of claims 40, 41 and 42, wherein said size is in the range of 0.01 mm to 1.0 mm.
47. A cartilage defect repair material as claimed in any one of claims 40, 41 and 42, wherein said allograft cartilage pieces are allograft articular cartilage pieces.
48. A cartilage defect repair material as claimed in any one of claims 40, 41 and 42, wherein said allograft cartilage pieces include hyaline cartilage.
49. A cartilage defect repair material as claimed in any one of claims 40, 41 and 42, wherein said allograft cartilage pieces lack cell viability.
50. A cartilage defect repair material as claimed in any one of claims 40, 41 and 42, wherein said cartilage defect repair material is free of added chondrocytes.
51. A cartilage defect repair material as claimed in any one of claims 40, 41 and 42, wherein said cartilage defect repair material is free of bone pieces.
52. A cartilage defect repair material as claimed in any one of claims 40, 41 and 42, wherein said mixture is formed for implantation directly in a defect site.
53. A cartilage defect repair material as claimed in any one of claims 40, 41 and 42, wherein said allograft cartilage pieces have an ability to promote the growth of new articular cartilage in a cartilage defect.
54. A cartilage defect repair material as claimed in claim 40, wherein said allograft cartilage pieces are present in said mixture in an amount in the range of from about 15% to about 30% by weight and said bioabsorbable carrier is present in said mixture in an amount in the range of from about 70% to about 85% by weight.
55. A cartilage defect repair material as claimed in claim 41, wherein said bioabsorbable carrier is present in said mixture at an amount in the range of from about 50% to about 75% by weight.
56. A cartilage defect repair material as claimed in claim 42, wherein said bioabsorbable carrier is present in said mixture in an amount within the range of from about 50% to about 85% by weight.
57. A cartilage defect repair material as claimed in any one of claims 40, 41 and 42, wherein said cartilage pieces are formed by freezing allograft cartilage with liquid nitrogen and milling the frozen cartilage.
58. A cartilage defect repair material as claimed in any one of claims 40, 41 and 42, wherein said allograft cartilage pieces are formed by milling frozen allograft articular cartilage.
59. A cartilage defect repair material as claimed in any one of claims 40, 41 and 42, wherein said cartilage pieces are formed by freeze-milling allograft cartilage subsequent to reducing the water content of the allograft cartilage.
60. A cartilage defect repair material as claimed in any one of claims 40, 41 and 42, wherein said allograft cartilage pieces are formed by a process including the steps of harvesting a donor tissue consisting essentially of articular cartilage, reducing the water content of said donor tissue, and freeze-milling said donor tissue.
61. A cartilage defect repair material for use in human beings, comprising freeze-milled allograft cartilage pieces having a size not greater than 1 mm, said cartilage pieces being included in a mixture, said mixture including a bioabsorbable carrier, and said allograft cartilage pieces including fibrocartilage.
62. A cartilage defect repair material for use in human beings, comprising freeze-milled allograft cartilage pieces having a size not greater than 1 mm, said cartilage pieces being included in a mixture, said mixture including a bioabsorbable carrier, and said allograft cartilage pieces including hyaline cartilage and fibrocartilage.
63. A cartilage defect repair material for use in human beings, comprising freeze-milled allograft cartilage pieces having a size not greater than 1 mm, said cartilage pieces being included in a mixture, and said mixture including a bioabsorbable carrier and a protein glue.
64. A cartilage defect repair material for use in human beings, comprising freeze-milled allograft cartilage pieces having a size not greater than 1 mm, said cartilage pieces being included in a mixture, and said mixture including a bioabsorbable carrier selected from the group consisting of sodium hyaluronate, hyaluronic acid, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran, and polymers.
65. A cartilage defect repair material for use in human beings, comprising freeze-milled allograft cartilage pieces having a size not greater than 1 mm, said cartilage pieces being included in a mixture, and said mixture including a bioabsorbable carrier selected from the group consisting of sodium hyaluronate and hyaluronic acid.
66. A cartilage defect repair material for use in human beings, comprising freeze-milled allograft cartilage pieces having a size not greater than 1 mm, said cartilage pieces being included in a mixture, and said mixture including a bioabsorbable carrier and an additive selected from the group consisting of a growth factor, human allogenic cells, human allogenic bone marrow cells, human autologous bone marrow cells, human allogenic stem cells, human autologous stem cells, human demineralized bone matrix, insulin, insulin-like growth factor-1, interleukin-1 receptor agonist, hepatocyte growth factor, platelet-derived growth factor, Indian hedgehog, and parathyroid hormone-related peptide.
67. A cartilage defect repair material as claimed in claim 66, wherein said growth factor is selected from the group consisting of FGF-2, FGF-5, IGF-1, TGF-β, BMP-2, BMP-7, PDGF, and VEGF.
68. A cartilage defect repair material for use in human beings, comprising freeze-milled allograft cartilage pieces having a size not greater than 1 mm, said cartilage pieces being included in a mixture, and said mixture including a bioabsorbable carrier and autologous chondrocytes at a concentration greater than the concentration of chondrocytes that are naturally present in hyaline cartilage of a human being having an age in the range of 20 years to 55 years.
69. A cartilage defect repair material for use in human beings, comprising freeze-milled allograft cartilage pieces having a size not greater than 1 mm, said cartilage pieces being included in a mixture, and said mixture including a bioabsorbable carrier and allogenic chondrocytes at a concentration greater than the concentration of chondrocytes that are naturally present in hyaline cartilage of a human being having an age in the range of 20 years to 55 years.
70. A cartilage defect repair material for use in human beings, comprising freeze-milled allograft cartilage pieces having a size not greater than 1 mm, said cartilage pieces being included in a mixture, and said mixture including a bioabsorbable carrier and autologous bone marrow cells at a concentration greater than the concentration of bone marrow cells that are naturally present in hyaline cartilage of a human being having an age in the range of 20 years to 55 years.
71. A cartilage defect repair material for use in human beings, comprising freeze-milled allograft cartilage pieces having a size not greater than 1 mm, said cartilage pieces being included in a mixture, and said mixture including a bioabsorbable carrier and autologous stem cells at a concentration greater than the concentration of stem cells that are naturally present in hyaline cartilage of a human being having an age in the range of 20 years to 55 years.
72. A method of repairing a cartilage defect in a human being, comprising the step of placing in a defect site freeze-milled allograft cartilage pieces having a size not greater than 1 mm.
73. A method as claimed in claim 72, wherein the cartilage pieces have a water content within the range of about 0.1% to about 8.0% by weight prior to their placement in the defect site.
74. A method as claimed in claim 72, wherein the cartilage pieces are formed from allograft cartilage having a reduced water content.
75. A method as claimed in claim 72, wherein the cartilage pieces are formed from allograft cartilage which has been dried so as to reduce its water content to an amount within the range of about 0.1% to about 8.0% by weight.
76. A method as claimed in claim 72, wherein the size of the cartilage pieces ranges from 0.01 mm to 1.0 mm.
77. A method as claimed in claim 72, wherein the cartilage pieces are formed by freezing allograft cartilage with liquid nitrogen and milling the frozen cartilage.
78. A method as claimed in claim 72, wherein the cartilage pieces are formed by freeze-milling allograft cartilage subsequent to reducing the water content of the allograft cartilage.
79. A method as claimed in claim 72, wherein the defect site includes a defect in articular cartilage.
80. A method as claimed in claim 72, wherein the freeze-milled allograft cartilage pieces consist essentially of articular cartilage.
81. A method as claimed in claim 72, wherein the freeze-milled allograft cartilage pieces lack cell viability.
82. A method as claimed in claim 72, comprising the further steps of harvesting a donor tissue consisting essentially of articular cartilage, reducing the water content of said donor tissue, and freeze-milling said donor tissue.
83. A method as claimed in claim 72, comprising the further step of forming the freeze-milled allograft cartilage pieces by a process including the step of milling frozen allograft articular cartilage.
84. A method as claimed in claim 72, wherein the allograft cartilage pieces are free of added chondrocytes.
85. A method as claimed in claim 79, wherein the cartilage pieces have an ability to promote the growth of new articular cartilage in the articular cartilage defect.
86. A method as claimed in claim 72, comprising the further steps of cutting a patient's tissue to remove a diseased area of cartilage from the defect site; and placing a cover over the allograft cartilage pieces so as to contain the allograft cartilage pieces in the defect site.
87. A method as claimed in claim 86, further comprising the step of adding cells to the defect site.
88. A method as claimed in claim 87, wherein the cells are selected from the group consisting of chondrocytes, bone marrow cells and stem cells.
89. A method as claimed in claim 72, wherein the cartilage pieces are included in a mixture, the mixture including a bioabsorbable carrier.
90. A method as claimed in claim 89, wherein said placing step includes the step of placing the mixture in the defect site, said method comprising the further steps of cutting a patient's tissue to remove a diseased area of cartilage from the defect site; and placing a cover over the mixture so as to contain the mixture in the defect site.
91. A method as claimed in claim 90, further comprising the step of adding cells to the defect site.
92. A method as claimed in claim 91, wherein the cells are selected from the group consisting of chondrocytes, bone marrow cells and stem cells.
93. A method as claimed in claim 90, comprising the further step of adding a growth factor to the mixture.
94. A method as claimed in claim 90, further comprising the step of fixing the mixture in the cartilage defect site with an organic glue.
95. A method as claimed in claim 90, further comprising the step of keeping the cover over the mixture for a predetermined period of time that is sufficient to promote cartilage growth at the defect site.
96. A method as claimed in claim 90, wherein the cover is selected from the group consisting of a periosteal flap and a perichondrial flap.
97. A method for making a cartilage defect repair material for use in human beings from allograft cartilage, said method comprising the steps of freeze-milling the allograft cartilage so as to form freeze-milled allograft cartilage pieces having a size not greater than 1 mm; and mixing the freeze-mill cartilage pieces with a bioabsorbable carrier to form a mixture in the form of a gel.
98. A method for making a cartilage defect repair material for use in human beings from allograft cartilage, said method comprising the steps of freeze-milling the allograft cartilage so as to form freeze-milled allograft cartilage pieces having a size not greater than 1 mm; and mixing the freeze-mill cartilage pieces with a bioabsorbable carrier to form a mixture in the form of a paste, the freeze-milled cartilage pieces being present in the mixture in an amount within the range of from about 25% to about 50% by weight.
99. A method for making a cartilage defect repair material for use in human beings from allograft cartilage, said method comprising the steps of freeze-milling the allograft cartilage so as to form freeze-milled allograft cartilage pieces having a size not greater than 1 mm; and mixing the freeze-mill cartilage pieces with a bioabsorbable carrier to form a mixture in the form of one of a paste and a gel, the freeze-milled cartilage pieces being present in the mixture in an amount within the range of from about 15% to about 50% by weight.
100. A method as claimed in any one of claims 97, 98 and 99, comprising the further step of reducing the water content of the allograft cartilage.
101. A method as claimed in claim 100, wherein said reducing step is performed so as to reduce the water content of the allograft cartilage to an amount within the range of about 0.1% to about 8.0% by weight.
102. A method as claimed in claim 100, wherein said reducing step is performed prior to said freeze-milling step.
103. A method as claimed in claim 100, wherein said reducing step includes the step of lyophilizing the allograft cartilage.
104. A method as claimed in any one of claims 97, 98 and 99, wherein said freeze-milling step includes the step of freezing the cartilage and the step of milling the frozen cartilage.
105. A method as claimed in any one of claims 97, 98 and 99, wherein said freeze-milling step is performed by milling the cartilage in a frozen state.
106. A method as claimed in any one of claims 97, 98 and 99, wherein the freeze-milled cartilage pieces have a water content within the range of about 0.1% to about 8.0% by weight.
107. A method as claimed in any one of claims 97, 98 and 99, wherein the size of the freeze-milled cartilage pieces ranges from 0.01 mm to 1.0 mm.
108. A method as claimed in any one of claims 97, 98 and 99, wherein the allograft cartilage includes allograft articular cartilage.
109. A method as claimed in any one of claims 97, 98 and 99, comprising the further step of harvesting the allograft cartilage from a donor tissue consisting essentially of articular cartilage.
110. A method as claimed in any one of claims 97, 41 and 42, wherein the mixture is formed for implantation directly in a defect site.
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090324683A1 (en) * 2008-03-25 2009-12-31 Evans Bruce G Controlled release tissue graft combination biomaterials
US9162011B2 (en) 2011-12-19 2015-10-20 Allosource Flowable matrix compositions and methods
US9186253B2 (en) 2013-02-22 2015-11-17 Allosource Cartilage mosaic compositions and methods
US9186380B2 (en) 2012-11-15 2015-11-17 Allosource Minced cartilage systems and methods
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
US9788950B1 (en) 2016-04-22 2017-10-17 Vivex Biomedical, Inc. Cohesive bone composition
US9889235B2 (en) 2013-02-05 2018-02-13 University Of Utah Research Foundation Implantable devices for bone or joint defects

Citations (475)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6183737B2 (en)
US3400199A (en) 1965-02-26 1968-09-03 Leslie L. Balassa Wound-healing cartilage powder
US3476855A (en) 1965-02-26 1969-11-04 Leslie L Balassa Sterilizing and enhancing activity of a finely divided cartilage powder
US3478146A (en) 1965-02-26 1969-11-11 Leslie L Balassa Wound-healing cartilage powder extracting process
US3551560A (en) 1967-10-02 1970-12-29 Heinrich F Thiele Process of reconstructing tendons,cartilage,nerve sheaths,and products
US3772432A (en) 1971-01-11 1973-11-13 Lescarden Ltd Cartilage compositions for dental use
US3867728A (en) 1971-12-30 1975-02-25 Cutter Lab Prosthesis for spinal repair
US3966908A (en) 1973-11-29 1976-06-29 Lescarden Ltd. Method of treating degenerative joint afflictions
US4060081A (en) 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
US4172128A (en) 1975-03-26 1979-10-23 Erhard Thiele Process of degrading and regenerating bone and tooth material and products
US4201845A (en) 1976-04-12 1980-05-06 Monsanto Company Cell culture reactor
US4296100A (en) 1980-06-30 1981-10-20 Franco Wayne P Method of treating the heart for myocardial infarction
US4378347A (en) 1980-06-30 1983-03-29 Franco Wayne P Composition for treating the heart for myocardial infarction
US4394370A (en) 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4400833A (en) 1981-06-10 1983-08-30 Kurland Kenneth Z Means and method of implanting bioprosthetics
US4442655A (en) 1981-06-25 1984-04-17 Serapharm Michael Stroetmann Fibrinogen-containing dry preparation, manufacture and use thereof
US4458678A (en) 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
US4479271A (en) 1981-10-26 1984-10-30 Zimmer, Inc. Prosthetic device adapted to promote bone/tissue ingrowth
GB2102811B (en) 1981-07-28 1985-01-30 Immuno Ag A tissue adhesive and a method of producing the same
US4501269A (en) 1981-12-11 1985-02-26 Washington State University Research Foundation, Inc. Process for fusing bone joints
US4505266A (en) 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
US4600574A (en) 1984-03-21 1986-07-15 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Method of producing a tissue adhesive
US4609551A (en) 1984-03-20 1986-09-02 Arnold Caplan Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
US4627853A (en) 1985-05-29 1986-12-09 American Hospital Supply Corporation Method of producing prostheses for replacement of articular cartilage and prostheses so produced
US4642120A (en) 1983-03-23 1987-02-10 Ramot University Authority For Applied Research And Industrial Development Ltd. Repair of cartilage and bones
US4656137A (en) 1985-09-12 1987-04-07 Lescarden Inc Method of processing animal cartilage
US4681763A (en) 1985-06-11 1987-07-21 University Of Medicine And Dentistry Of New Jersey Composition for stimulating bone growth
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4757017A (en) 1984-09-14 1988-07-12 Mcw Research Foundation, Inc. In vitro cell culture system
US4776853A (en) 1986-07-28 1988-10-11 Hsc Research Development Corporation Process for preparing biological mammalian implants
US4776173A (en) 1985-12-20 1988-10-11 Angio-Medical Corporation Method for extracting a substance from animal derived material
US4795467A (en) 1985-03-28 1989-01-03 Collagen Corporation Xenogeneic collagen/mineral preparations in bone repair
US4801299A (en) 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US4837379A (en) 1988-06-02 1989-06-06 Organogenesis Inc. Fibrin-collagen tissue equivalents and methods for preparation thereof
US4846835A (en) 1987-06-15 1989-07-11 Grande Daniel A Technique for healing lesions in cartilage
US4880429A (en) 1987-07-20 1989-11-14 Stone Kevin R Prosthetic meniscus
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4904259A (en) 1988-04-29 1990-02-27 Samuel Itay Compositions and methods for repair of cartilage and bone
US4932973A (en) 1983-09-30 1990-06-12 El Gendler Cartilage and bone induction by artificially perforated organic bone matrix
US4950483A (en) 1988-06-30 1990-08-21 Collagen Corporation Collagen wound healing matrices and process for their production
US4950296A (en) 1988-04-07 1990-08-21 Mcintyre Jonathan L Bone grafting units
US4955911A (en) 1988-04-21 1990-09-11 Sulzer Brothers Limited Bone implant
US4963489A (en) 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US4963146A (en) 1989-04-20 1990-10-16 Colla-Tec Incorporated Multi-layered, semi-permeable conduit for nerve regeneration
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4971954A (en) 1988-11-23 1990-11-20 University Of Medicine And Dentistry Of New Jersey Collagen-based matrices ribose cross-linked
US4976738A (en) 1985-01-09 1990-12-11 Sulzer Brothers Limited Porous metal overlay for an implant surface
US4978355A (en) 1985-01-25 1990-12-18 Sulzer Brothers Limited Plastic bone implant having a reinforced contact surface
US4994084A (en) 1989-06-23 1991-02-19 Brennan H George Reconstructive surgery method and implant
US4994559A (en) 1985-12-17 1991-02-19 Synergen, Inc. Human basic fibroblast growth factor
US5002071A (en) 1987-04-03 1991-03-26 Research Development Foundation Injectable soft tissue augmentation materials from the placenta and their method of manufacture
US5002583A (en) 1985-08-13 1991-03-26 Sandu Pitaru Collagen implants
US5007934A (en) 1987-07-20 1991-04-16 Regen Corporation Prosthetic meniscus
US5032508A (en) 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US5053049A (en) 1985-05-29 1991-10-01 Baxter International Flexible prostheses of predetermined shapes and process for making same
US5053050A (en) 1988-04-29 1991-10-01 Samuel Itay Compositions for repair of cartilage and bone
US5067963A (en) 1990-08-21 1991-11-26 Washington University Method of making live autogenous skeletal replacement parts
US5067964A (en) 1989-12-13 1991-11-26 Stryker Corporation Articular surface repair
US5073373A (en) 1989-09-21 1991-12-17 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5084051A (en) 1986-11-03 1992-01-28 Toermaelae Pertti Layered surgical biocomposite material
US5092887A (en) 1991-08-12 1992-03-03 El Gendler Artificial ligament produced from demineralized bone for the replacement and augmentation of ligaments, tendons and other fibrous connective tissue
US5118512A (en) 1990-01-23 1992-06-02 Osteotech, Inc. (A Delaware Corp.) Process for cryopreserving biological materials and materials prepared thereby
US5152791A (en) 1989-12-07 1992-10-06 Olympus Optical Co., Ltd. Prosthetic artificial bone having ceramic layers of different porosity
US5155214A (en) 1984-03-05 1992-10-13 The Salk Institute For Biological Studies Basic fibroblast growth factor
EP0517030A2 (en) 1991-06-04 1992-12-09 MAN Ceramics GmbH Vertebral implant
EP0522569A1 (en) 1991-07-12 1993-01-13 United States Surgical Corporation Composition for effecting bone repair
US5191067A (en) 1989-04-27 1993-03-02 The Salk Institute For Biological Studies Fibroblast growth factor conjugates
US5195892A (en) 1990-07-23 1993-03-23 Odontit S.A. Bone-integrated dental implant system
US5206023A (en) 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5226914A (en) 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5236456A (en) 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5256140A (en) 1992-03-27 1993-10-26 Fallien Cosmeceuticals, Ltd. Composition for levelling skin
US5260420A (en) 1987-07-30 1993-11-09 Centre Regional De Transfusion Sanguine De Lille Concentrate of thrombin coagulable proteins, the method of obtaining same and therapeutical use thereof
US5266476A (en) 1985-06-18 1993-11-30 Yeda Research & Development Co., Ltd. Fibrous matrix for in vitro cell cultivation
US5270300A (en) 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5284155A (en) 1991-12-06 1994-02-08 The General Hospital Corporation Cartilage degradation assay system
US5290558A (en) 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5302702A (en) 1990-11-23 1994-04-12 American Cyanamid Company Chimeric fibroblast growth factors
US5306304A (en) 1990-10-31 1994-04-26 El Gendler Flexible membranes produced from organic bone matrix for skeletal repair and reconstruction
US5306311A (en) 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US5314476A (en) 1992-02-04 1994-05-24 Osteotech, Inc. Demineralized bone particles and flowable osteogenic composition containing same
US5326357A (en) 1992-03-18 1994-07-05 Mount Sinai Hospital Corporation Reconstituted cartridge tissue
US5329846A (en) 1991-08-12 1994-07-19 Bonutti Peter M Tissue press and system
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
US5338772A (en) 1991-06-20 1994-08-16 Merck Patent Gesellschaft Mit Beschrankter Haftung Implant material
US5352463A (en) 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
US5354557A (en) 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5380328A (en) 1993-08-09 1995-01-10 Timesh, Inc. Composite perforated implant structures
US5411885A (en) 1993-12-17 1995-05-02 New York Blood Center, Inc. Methods for tissue embedding and tissue culturing
US5425769A (en) 1990-04-23 1995-06-20 Snyders, Jr.; Robert V. Composition of material for osseous repair
US5439818A (en) 1985-09-12 1995-08-08 Scios Nova Inc. DNA encoding human recombinant basic fibroblast growth factor
US5443950A (en) 1986-04-18 1995-08-22 Advanced Tissue Sciences, Inc. Three-dimensional cell and tissue culture system
US5466462A (en) 1992-03-25 1995-11-14 Johnson & Johnson Medical, Inc. Heteromorphic sponges containing active agents
US5491220A (en) 1993-09-24 1996-02-13 Yeda Research And Development Co., Ltd. Surface loop structural analogues of fibroblast growth factors
US5496722A (en) 1988-06-30 1996-03-05 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method for producing non-neoplastic, three dimensional, mammalian tissue and cell aggregates under microgravity culture conditions and the products produced therefrom
US5507813A (en) 1993-12-09 1996-04-16 Osteotech, Inc. Shaped materials derived from elongate bone particles
US5512460A (en) 1991-02-14 1996-04-30 Takeda Chemical Industries, Ldt Glia activating factor and its production
US5513662A (en) 1991-12-31 1996-05-07 Osteotech, Inc. Preparation of bone for transplantation
US5516532A (en) 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5549904A (en) 1993-06-03 1996-08-27 Orthogene, Inc. Biological adhesive composition and method of promoting adhesion between tissue surfaces
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
US5569272A (en) 1991-01-31 1996-10-29 Carnegie Mellon University Tissue-connective devices with micromechanical barbs
EP0739631A2 (en) 1995-04-26 1996-10-30 El Gendler Laminar bone support for cartilage growth
US5571895A (en) 1992-12-22 1996-11-05 Takeda Chemical Industries, Ltd. Modified GAF polypeptides
US5576288A (en) 1989-04-27 1996-11-19 The Salk Institute For Biological Studies Fibroblast growth factor conjugates
US5604293A (en) 1985-09-12 1997-02-18 Scios Inc. Recombinant human basic fibroblast growth factor
US5607474A (en) 1992-02-14 1997-03-04 Board Of Regents, University Of Texas System Multi-phase bioerodible implant/carrier and method of manufacturing and using same
EP0762903A1 (en) 1994-06-03 1997-03-19 Creative Biomolecules, Inc. Manufacture of autogenous replacement body parts
US5614496A (en) 1994-03-08 1997-03-25 Osteosa Inc. Use of fibroblast growth factors to stimulate bone growth
US5618925A (en) 1994-04-28 1997-04-08 Les Laboratories Aeterna Inc. Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof
US5631011A (en) 1991-06-17 1997-05-20 Wadstroem; Jonas Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer
US5632745A (en) 1995-02-07 1997-05-27 R&D Biologicals, Inc. Surgical implantation of cartilage repair unit
EP0784985A1 (en) 1994-09-30 1997-07-23 Yamanouchi Pharmaceutical Co. Ltd. Osteoplastic graft
US5656598A (en) 1994-03-08 1997-08-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Use of fibroblast growth factors to stimulate bone growth
US5681353A (en) 1987-07-20 1997-10-28 Regen Biologics, Inc. Meniscal augmentation device
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US5700774A (en) 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
US5707962A (en) 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
US5713374A (en) 1995-02-10 1998-02-03 The Hospital For Joint Diseases Orthopaedic Institute Fixation method for the attachment of wound repair materials to cartilage defects
US5716413A (en) 1995-10-11 1998-02-10 Osteobiologics, Inc. Moldable, hand-shapable biodegradable implant material
US5723331A (en) 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US5728159A (en) 1997-01-02 1998-03-17 Musculoskeletal Transplant Foundation Serrated bone graft
US5733337A (en) 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5736372A (en) 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US5749874A (en) 1995-02-07 1998-05-12 Matrix Biotechnologies, Inc. Cartilage repair unit and method of assembling same
US5755791A (en) 1996-04-05 1998-05-26 Purdue Research Foundation Perforated submucosal tissue graft constructs
US5759190A (en) 1996-08-30 1998-06-02 Vts Holdings Limited Method and kit for autologous transplantation
US5770417A (en) 1986-11-20 1998-06-23 Massachusetts Institute Of Technology Children's Medical Center Corporation Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo
US5769899A (en) 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
US5782835A (en) 1995-03-07 1998-07-21 Innovasive Devices, Inc. Apparatus and methods for articular cartilage defect repair
US5782915A (en) 1995-09-15 1998-07-21 Stone; Kevin R. Articular cartilage heterografts
US5788625A (en) 1996-04-05 1998-08-04 Depuy Orthopaedics, Inc. Method of making reconstructive SIS structure for cartilaginous elements in situ
US5800537A (en) 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
US5814084A (en) 1996-01-16 1998-09-29 University Of Florida Tissue Bank, Inc. Diaphysial cortical dowel
US5842477A (en) 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US5853746A (en) 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
US5855620A (en) 1995-04-19 1999-01-05 St. Jude Medical, Inc. Matrix substrate for a viable body tissue-derived prosthesis and method for making the same
US5859208A (en) 1988-07-06 1999-01-12 Fiddes; John C. Human basic fibroblast growth factor analog
US5863296A (en) 1991-03-05 1999-01-26 Colorado State University Research Foundation Treated tissue for implantation and methods of treatment and use
US5866415A (en) 1997-03-25 1999-02-02 Villeneuve; Peter E. Materials for healing cartilage and bone defects
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US5881733A (en) 1996-09-13 1999-03-16 Depuy Orthopaedic Technology, Inc. Technique for osteocartilaginous transplantation in a mammalian joint
US5891558A (en) 1994-11-22 1999-04-06 Tissue Engineering, Inc. Biopolymer foams for use in tissue repair and reconstruction
US5893888A (en) 1992-08-07 1999-04-13 Tissue Engineering, Inc. Method and construct for producing graft tissue from extracellular matrix
US5899936A (en) 1994-03-14 1999-05-04 Cryolife, Inc. Treated tissue for implantation and methods of preparation
US5899939A (en) 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US5910315A (en) 1997-07-18 1999-06-08 Stevenson; Sharon Allograft tissue material for filling spinal fusion cages or related surgical spaces
US5916265A (en) 1994-03-30 1999-06-29 Hu; Jie Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant
US5948429A (en) 1994-11-22 1999-09-07 Tissue Engineering, Inc. Methods for preparing biopolymer foams
US5955438A (en) 1994-07-19 1999-09-21 Colbar R & D Ltd. Collagen-based matrix
US5964805A (en) 1997-02-12 1999-10-12 Stone; Kevin R. Method and paste for articular cartilage transplantation
US5972385A (en) 1997-01-15 1999-10-26 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
US5972368A (en) 1997-06-11 1999-10-26 Sdgi Holdings, Inc. Bone graft composites and spacers
US5974663A (en) 1996-10-25 1999-11-02 Honda Giken Kogya Kabushiki Kaisha Method of manufacturing connecting rod
US5989866A (en) 1996-10-16 1999-11-23 Zymogenetics, Inc. FGF homologs
US5989269A (en) 1996-08-30 1999-11-23 Vts Holdings L.L.C. Method, instruments and kit for autologous transplantation
US5989289A (en) 1995-10-16 1999-11-23 Sdgi Holdings, Inc. Bone grafts
US5998170A (en) 1997-10-03 1999-12-07 Amgen Inc. Polynucleotides encoding hepatocyte-specific members of the FGF family
US6001352A (en) 1997-03-31 1999-12-14 Osteobiologics, Inc. Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor
US6005161A (en) 1986-01-28 1999-12-21 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
US6013853A (en) 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US6025538A (en) 1998-11-20 2000-02-15 Musculoskeletal Transplant Foundation Compound bone structure fabricated from allograft tissue
US6025334A (en) 1994-04-28 2000-02-15 Les Laboratoires Aeterna Inc. Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof
US6030635A (en) 1998-02-27 2000-02-29 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6037171A (en) 1995-10-06 2000-03-14 Microcloning Cccd Ab Cell culture microchambers in a grid matrix sandwiched between a planar base and semipermeable membrane
US6039762A (en) 1995-06-07 2000-03-21 Sdgi Holdings, Inc. Reinforced bone graft substitutes
US6056777A (en) 1998-02-27 2000-05-02 Mcdowell; Charles L. Method and device for regenerating cartilage in articulating
US6060640A (en) 1995-05-19 2000-05-09 Baxter International Inc. Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue
US6074663A (en) 1995-01-16 2000-06-13 Baxter International Inc. Method of using cross-linked fibrin material
US6080194A (en) 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
US6090996A (en) 1997-08-04 2000-07-18 Collagen Matrix, Inc. Implant matrix
US6090998A (en) 1997-10-27 2000-07-18 University Of Florida Segmentally demineralized bone implant
US6096347A (en) 1996-11-05 2000-08-01 Purdue Research Foundation Myocardial graft constructs
US6110209A (en) 1997-08-07 2000-08-29 Stone; Kevin R. Method and paste for articular cartilage transplantation
US6123731A (en) 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US6143293A (en) 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
US6146385A (en) 1997-02-11 2000-11-14 Smith & Nephew, Inc. Repairing cartilage
US6165486A (en) 1998-11-19 2000-12-26 Carnegie Mellon University Biocompatible compositions and methods of using same
US6165487A (en) 1996-09-30 2000-12-26 Children's Medical Center Corporation Methods and compositions for programming an organic matrix for remodeling into a target tissue
US6183737B1 (en) 1997-10-30 2001-02-06 The General Hospital Corporation Bonding of cartilage pieces using isolated chondrocytes and a biological gel
US6189537B1 (en) 1996-09-06 2001-02-20 Lifenet Process for producing osteoinductive bone, and osteoinductive bone produced thereby
US6197061B1 (en) 1999-03-01 2001-03-06 Koichi Masuda In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage
US6197586B1 (en) 1997-12-12 2001-03-06 The Regents Of The University Of California Chondrocyte-like cells useful for tissue engineering and methods
US6200347B1 (en) 1999-01-05 2001-03-13 Lifenet Composite bone graft, method of making and using same
US6221854B1 (en) 1996-03-05 2001-04-24 Orquest, Inc. Method of promoting bone growth with hyaluronic acid and growth factors
US6231607B1 (en) 1995-12-21 2001-05-15 Hadasit Medical Research Services & Development Company Ltd. Bone graft substitute and its preparation
US6235316B1 (en) 1997-04-04 2001-05-22 Barnes-Jewish Hospital Neocartilage and methods of use
US6242247B1 (en) 1996-06-04 2001-06-05 Sulzer Orthopedics Ltd. Method for making cartilage and implants
US6251143B1 (en) 1999-06-04 2001-06-26 Depuy Orthopaedics, Inc. Cartilage repair unit
US6258778B1 (en) 1998-07-13 2001-07-10 University Of Southern California Methods for accelerating bone and cartilage growth and repair
US6267786B1 (en) 1999-02-11 2001-07-31 Crosscart, Inc. Proteoglycan-reduced soft tissue xenografts
US20010011131A1 (en) 1997-07-28 2001-08-02 Luyten Frank P. DNA molecules encoding cartilage-derived morphogenetic proteins
US6270528B1 (en) 1998-08-06 2001-08-07 Sdgi Holdings, Inc. Composited intervertebral bone spacers
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
US6274663B1 (en) 1997-10-30 2001-08-14 Showa Denko K.K. Compound resin composition
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US6281195B1 (en) 1997-02-07 2001-08-28 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US6280473B1 (en) 1996-08-19 2001-08-28 Macropore, Inc. Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration
US20010018619A1 (en) 1998-12-22 2001-08-30 Robert-Jan Enzerink Graft material convenience package
US6288043B1 (en) 1999-06-18 2001-09-11 Orquest, Inc. Injectable hyaluronate-sulfated polysaccharide conjugates
US6294187B1 (en) 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
US6293970B1 (en) 1998-06-30 2001-09-25 Lifenet Plasticized bone and soft tissue grafts and methods of making and using same
US6303585B1 (en) 1997-07-03 2001-10-16 Orquest, Inc. Cross-linked polysaccharide drug carrier
US20010031254A1 (en) 1998-11-13 2001-10-18 Bianchi John R. Assembled implant
US6306174B1 (en) 1998-12-18 2001-10-23 Benoist Girard Sas Femoral component
US6306177B1 (en) 1994-05-06 2001-10-23 Advanced Bio Surfaces, Inc. Biomaterial system for in situ tissue repair
US6306424B1 (en) 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
US6310267B1 (en) 1998-11-06 2001-10-30 Aventis Behring Gmbh Flexible wound covering based on fibrin and process for its production
US20010039457A1 (en) 2000-03-22 2001-11-08 Boyer Michael L. Plugs for filling bony defects
US6319712B1 (en) 1998-01-30 2001-11-20 Deutsche Institute Fur Textil-Und Faserforschung Stuttgart Biohybrid articular surface replacement
US20010051834A1 (en) 1999-03-24 2001-12-13 Chondros, Inc. Method for composite cell-based implants
US6333029B1 (en) 1999-06-30 2001-12-25 Ethicon, Inc. Porous tissue scaffoldings for the repair of regeneration of tissue
US20020009805A1 (en) 1999-07-06 2002-01-24 Ramot University Authority For Applied Research & Industrial Development Ltd. Scaffold matrix and tissue maintaining systems
US20020016592A1 (en) 1998-08-27 2002-02-07 Branch Charles L. Interbody fusion grafts and instrumentation
US6352558B1 (en) 1996-02-22 2002-03-05 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damage joint
US20020035401A1 (en) 2000-07-03 2002-03-21 Osteotech, Inc. Osteogenic implants derived from bone
US20020042373A1 (en) 2000-07-20 2002-04-11 The Board Of Regents, The University Of Texas System Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor
US6371958B1 (en) 2000-03-02 2002-04-16 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US20020045940A1 (en) 1998-08-14 2002-04-18 Bruno Giannetti Methods, instruments and materials for chondrocyte cell transplantation
US6376244B1 (en) 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
US6379385B1 (en) 2000-01-06 2002-04-30 Tutogen Medical Gmbh Implant of bone matter
US6383221B1 (en) 1999-01-22 2002-05-07 Osteotech, Inc. Method for forming an intervertebral implant
US20020055783A1 (en) 2000-05-01 2002-05-09 Tallarida Steven J. System and method for joint resurface repair
US6398972B1 (en) 1999-04-12 2002-06-04 Harvest Technologies Corporation Method for producing platelet rich plasma and/or platelet concentrate
US6398816B1 (en) 1997-09-04 2002-06-04 North Shore-Long Island Jewish Research Institute Genetic engineering of cells to enhance healing and tissue regeneration
US20020072806A1 (en) 2000-01-11 2002-06-13 Dayna Buskirk Soft and calcified tissue implants
US20020082704A1 (en) 2000-05-15 2002-06-27 Cryolife, Inc. Osteochondral transplant techniques
US20020099448A1 (en) 1996-08-23 2002-07-25 Michael C. Hiles Multi-formed collagenous biomaterial medical device
US20020106393A1 (en) 2000-02-10 2002-08-08 Bianchi John R. Assembled implant, including mixed-composition segment
US6432436B1 (en) 2000-10-03 2002-08-13 Musculoskeletal Transplant Foundation Partially demineralized cortical bone constructs
US20020111695A1 (en) 1995-11-06 2002-08-15 Mount Sinai Hospital Corporation Reconstituted mineralized cartilage tissue
US6437018B1 (en) 1998-02-27 2002-08-20 Musculoskeletal Transplant Foundation Malleable paste with high molecular weight buffered carrier for filling bone defects
US6440427B1 (en) 1991-06-17 2002-08-27 Biovitrum Ab Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer
US6440141B1 (en) 2000-07-24 2002-08-27 Oratec Interventions, Inc. Method and apparatus for treating osteochondral pathologies
EP1234552A1 (en) 2001-02-26 2002-08-28 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
EP1234555A2 (en) 2001-02-26 2002-08-28 Ethicon, Inc. Tissue scaffold anchor for cartilage repair
EP1237511A1 (en) 1999-12-15 2002-09-11 Sulzer Orthopedics Ltd. Preparation for repairing cartilage defects or cartilage/bone defects in human or animal joints
US6454811B1 (en) 1998-10-12 2002-09-24 Massachusetts Institute Of Technology Composites for tissue regeneration and methods of manufacture thereof
US20020138143A1 (en) 1997-08-27 2002-09-26 Grooms Jamie M. Cortical bone cervical Smith-Robinson fusion implant
US6458375B1 (en) 1998-02-27 2002-10-01 Musculoskeletal Transplant Foundation Malleable paste with allograft bone reinforcement for filling bone defects
US6458144B1 (en) 1999-12-30 2002-10-01 Osteotech, Inc. Methods for manufacturing skeletal implants
US6471993B1 (en) 1997-08-01 2002-10-29 Massachusetts Institute Of Technology Three-dimensional polymer matrices
US6475175B1 (en) 1996-01-31 2002-11-05 John Rivera Method and apparatus for sequestering platelet rich plasma
US20020177224A1 (en) 2001-03-15 2002-11-28 Henning Madry Tissue engineering enhanced by the transfer of a growth factor gene
US20020192263A1 (en) 1998-02-27 2002-12-19 Merboth Barbara L. Allograft bone composition having a gelatin binder
US6497726B1 (en) 2000-01-11 2002-12-24 Regeneration Technologies, Inc. Materials and methods for improved bone tendon bone transplantation
US6504079B2 (en) 1995-06-07 2003-01-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US6503277B2 (en) 1991-08-12 2003-01-07 Peter M. Bonutti Method of transplanting human body tissue
US6511511B1 (en) 1997-05-30 2003-01-28 Osteobiologics, Inc. Fiber-reinforced, porous, biodegradable implant device
US6511958B1 (en) 1997-08-14 2003-01-28 Sulzer Biologics, Inc. Compositions for regeneration and repair of cartilage lesions
WO2003007879A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Cartilage repair and regeneration scaffold and method
US20030021827A1 (en) 2001-07-16 2003-01-30 Prasanna Malaviya Hybrid biologic/synthetic porous extracellular matrix scaffolds
US20030023316A1 (en) 2000-08-04 2003-01-30 Brown Laura Jean Hybrid biologic-synthetic bioabsorable scaffolds
WO2003007805A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Cartilage repair apparatus and method
US6514514B1 (en) 1997-08-14 2003-02-04 Sùlzer Biologics Inc. Device and method for regeneration and repair of cartilage lesions
US20030032961A1 (en) 2001-07-16 2003-02-13 Pelo Mark Joseph Devices from naturally occurring biologically derived materials
US20030036797A1 (en) 2001-07-16 2003-02-20 Prasanna Malaviya Meniscus regeneration device and method
US20030039695A1 (en) 2001-08-10 2003-02-27 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Collagen carrier of therapeutic genetic material, and method
US20030040113A1 (en) 2001-03-23 2003-02-27 Histogenics Corporation Composition and methods for the production of biological tissues and tissue constructs
US20030044444A1 (en) 2001-07-16 2003-03-06 Prasanna Malaviya Porous extracellular matrix scaffold and method
US6530956B1 (en) 1998-09-10 2003-03-11 Kevin A. Mansmann Resorbable scaffolds to promote cartilage regeneration
US20030049299A1 (en) 2001-07-16 2003-03-13 Prasanna Malaviya Porous delivery scaffold and method
US20030050709A1 (en) 2001-02-23 2003-03-13 Ulrich Noth Trabecular bone-derived human mesenchymal stem cells
US20030055502A1 (en) 2001-05-25 2003-03-20 Philipp Lang Methods and compositions for articular resurfacing
US6541024B1 (en) 1996-04-19 2003-04-01 Osiris Therapeutics, Inc. Regeneration and augmentation of bone using mesenchymal stem cells
US6548729B1 (en) 1997-09-19 2003-04-15 Baxter Aktiengesellschaft Fibrin sponge
US20030077281A1 (en) 1997-09-16 2003-04-24 Cone Robert E. Immunointeractive molecules and uses therefor
US20030078617A1 (en) 2001-07-16 2003-04-24 Schwartz Herbert E. Unitary surgical device and method
US6569172B2 (en) 1996-08-30 2003-05-27 Verigen Transplantation Service International (Vtsi) Method, instruments, and kit for autologous transplantation
US20030099620A1 (en) 1997-10-30 2003-05-29 The General Hospital Corporation Bonding of cartilaginous matrices using isolated chondrocytes
US6576015B2 (en) 2000-07-19 2003-06-10 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Bone material and collagen combination for repair of injured joints
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US6579538B1 (en) 1999-12-22 2003-06-17 Acell, Inc. Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof
US6582960B1 (en) 1998-09-18 2003-06-24 Massachusetts Institute Of Technology Use of fibroblast growth factor 2 for expansion of chondrocytes and tissue engineering
US6591581B2 (en) 2000-03-08 2003-07-15 Arthrex, Inc. Method for preparing and inserting round, size specific osteochondral cores in the knee
US6599515B1 (en) 1995-01-16 2003-07-29 Baxter International Inc. Fibrin porous structure
US20030144743A1 (en) 2000-05-12 2003-07-31 Edwards Jean T. Osteoimplant and method for making same
US6623963B1 (en) 1999-12-20 2003-09-23 Verigen Ag Cellular matrix
US6626950B2 (en) 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
US6652592B1 (en) 1997-10-27 2003-11-25 Regeneration Technologies, Inc. Segmentally demineralized bone implant
US6652593B2 (en) 2001-02-28 2003-11-25 Synthes (Usa) Demineralized bone implants
US20030229400A1 (en) 2002-05-13 2003-12-11 Koichi Masuda Tissue engineered osteochondral implant
US20030236573A1 (en) 2002-06-13 2003-12-25 Evans Douglas G. Devices and methods for treating defects in the tissue of a living being
US6686184B1 (en) 2000-05-25 2004-02-03 President And Fellows Of Harvard College Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks
US6689747B2 (en) 2000-03-24 2004-02-10 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
US20040028717A1 (en) 1999-11-24 2004-02-12 Transtissue Technologies, Gmbh Implantable substrates for the healing and protection of connective tissue, preferably cartilage
US20040033212A1 (en) 2000-07-29 2004-02-19 Thomson Brian Mark Tissue implant
US6696073B2 (en) 1999-02-23 2004-02-24 Osteotech, Inc. Shaped load-bearing osteoimplant and methods of making same
US20040039447A1 (en) 2000-03-14 2004-02-26 Ultra Tec Manufacturing, Inc. Cartilage repair plug
US20040044408A1 (en) 1998-04-08 2004-03-04 Hungerford David S. Cell-culture and polymer constructs
US6712851B1 (en) 1998-01-23 2004-03-30 Macropore Biosurgery, Inc. Resorbable, macro-porous non-collapsing and flexible membrane barrier for skeletal repair and regeneration
US20040062753A1 (en) 2002-09-27 2004-04-01 Alireza Rezania Composite scaffolds seeded with mammalian cells
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
US6730314B2 (en) 2000-08-29 2004-05-04 Merck Patent Gesellschaft Culturing encapsulated chondrocytes under reduced oxygen partial pressure to produce cartilage implants
US6734018B2 (en) 1999-06-07 2004-05-11 Lifenet Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
USRE38522E1 (en) 1998-02-27 2004-05-25 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US20040102850A1 (en) 2002-11-25 2004-05-27 Shepard Yolanda Denise Cortical and cancellous allograft spacer
US6752834B2 (en) 1997-10-10 2004-06-22 Ed Geistlich Soehne Ag Fuer Chemische Industrie Membrane for in guided tissue regeneration
US6761887B1 (en) 1998-11-16 2004-07-13 Osiris Therapeutics, Inc. Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells
US20040134502A1 (en) 2002-03-22 2004-07-15 Shuichi Mizuno Method for in situ repair of injured, damaged, diseased or aged articular cartilage
US20040143344A1 (en) 2001-07-16 2004-07-22 Prasanna Malaviya Implantable tissue repair device and method
US20040151705A1 (en) 2002-03-22 2004-08-05 Shuichi Mizuno Neo-cartilage constructs and a method for preparation thereof
WO2004067704A2 (en) 2003-01-30 2004-08-12 Prochon Biotech Ltd. Freeze-dried fibrin matrices and methods for preparation thereof
WO2004069298A1 (en) 2003-02-06 2004-08-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Fgf-2 derived proteins for the preparation of biomaterials or medical devices such as stents
US20040166169A1 (en) 2002-07-15 2004-08-26 Prasanna Malaviya Porous extracellular matrix scaffold and method
US20040170610A1 (en) 2001-03-05 2004-09-02 Shimon Slavin Compositions comprising bone marrow cells together with demineralized and/or mineralized bone matrix and uses thereof in the induction of bone and cartilage formation
US20040175826A1 (en) 2003-03-03 2004-09-09 Technion Research & Development Foundation Ltd. Cultured cartilage/bone cells/tissue, method of generating same and uses thereof
WO2004075940A1 (en) 2003-02-26 2004-09-10 Zimmer Orthobiologics, Inc. Preparation for repairing cartilage tissue, especially articular cartilage defects
US20040193268A1 (en) 2003-03-31 2004-09-30 Hazebrouck Stephen A. Intercalary prosthesis, kit and method
US20040197373A1 (en) 1998-02-27 2004-10-07 Gertzman Arthur A. Composition for filling bone defects
US20040197311A1 (en) 2002-07-19 2004-10-07 Brekke John H. Device for regeneration of articular cartilage and other tissue
US20040219182A1 (en) 2003-04-29 2004-11-04 Gomes Katherine A. Novel glue for cartilage repair
US20040230303A1 (en) 2003-05-16 2004-11-18 Gomes Katherine A. Cartilage allograft plug
US20040243242A1 (en) 2001-02-14 2004-12-02 Sybert Daryl R. Implant derived from bone
US6838440B2 (en) 2001-01-24 2005-01-04 Collagen Nutraceuticals, Inc. Kolla2-desiccated avian sternal cartilage powder
US20050004672A1 (en) 1995-10-16 2005-01-06 John Pafford Bone grafts
US6841150B2 (en) 1999-08-19 2005-01-11 Artecal, Sciences, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
US20050020500A1 (en) 2002-01-23 2005-01-27 Bojang Shen Nutraceuticals for the treatment, protection and restoration of connective tissues
US6849255B2 (en) 1998-08-18 2005-02-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods and compositions for enhancing cartilage repair
US6852331B2 (en) 2002-02-11 2005-02-08 Taipei Biotechnology Ltd., Inc. Fabrication of a cartilage implant
US6855167B2 (en) 2001-12-05 2005-02-15 Osteotech, Inc. Spinal intervertebral implant, interconnections for such implant and processes for making
US20050043814A1 (en) 2003-08-20 2005-02-24 Akihiko Kusanagi Acellular matrix implanted into an articular cartilage or osteochondral lesion protected with a biodegradable polymer modified to have extended polymerization time and methods for preparation and use thereof
US20050064042A1 (en) 2003-04-29 2005-03-24 Musculoskeletal Transplant Foundation Cartilage implant plug with fibrin glue and method for implantation
US20050074476A1 (en) 2003-10-03 2005-04-07 El Gendler Cartilidge and bone induction by artificially perforated organic bone matrix augmented by undifferentiated cells suspended in bone gel
US6884428B2 (en) 2000-12-21 2005-04-26 Depuy Mitek, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6890354B2 (en) 2002-03-08 2005-05-10 Musculoskeletal Transplant Foundation Bone-tendon-bone assembly with allograft bone block and method for inserting same
US20050125077A1 (en) 2003-12-05 2005-06-09 Harmon Alexander M. Viable tissue repair implants and methods of use
US6911212B2 (en) 1998-02-27 2005-06-28 Musculoskeletal Transplant Foundation Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects
WO2005058207A1 (en) 2003-12-11 2005-06-30 Isto Technologies, Inc. Particulate cartilage system
US20050159822A1 (en) 1998-06-19 2005-07-21 Lifecell Corporation, A Delaware Corporation Particulate acellular tissue matrix
US20050159820A1 (en) 2002-05-13 2005-07-21 Hideki Yoshikawa Member for regenerating joint cartilage and process for producing the same, method of regenerating joint cartilage and artificial cartilage for transplantation
EP1561481A2 (en) 2004-02-09 2005-08-10 DePuy Mitek, Inc. Scaffolds with viable tissue
US6932977B2 (en) 2000-04-14 2005-08-23 Depuy Spine, Inc. Method of inducing or enhancing chondrogenesis with extracellular matrix containing BMP-4
US6933328B2 (en) 2000-04-03 2005-08-23 Universiteit Gent Composition of crosslinkable prepolymers for biodegradable implants
US20050196460A1 (en) 2004-03-08 2005-09-08 Malinin Theodore I. Particulate cartilage compositions, processes for their preparation and methods for regenerating cartilage
US20050209705A1 (en) 2004-03-09 2005-09-22 Niederauer Gabriele G Implant scaffold combined with autologous or allogenic tissue
US20050222687A1 (en) 2004-04-02 2005-10-06 Gordana Vunjak-Novakovic Cartilage implant assembly and method for implantation
US20050228498A1 (en) 2003-11-18 2005-10-13 Todd Andres Osteoconductive integrated spinal cage and method of making same
US20050240281A1 (en) 1997-05-30 2005-10-27 Slivka Michael A Fiber-reinforced, porous, biodegradable implant device
US20050251268A1 (en) 2003-05-16 2005-11-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20050260612A1 (en) 2003-10-02 2005-11-24 Depuy Spine, Inc. Chemical treatment for removing cellular and nuclear material from naturally occurring extracellular matrix-based biomaterials
US20050288796A1 (en) 2004-06-23 2005-12-29 Hani Awad Native soft tissue matrix for therapeutic applications
US6989034B2 (en) 2002-05-31 2006-01-24 Ethicon, Inc. Attachment of absorbable tissue scaffolds to fixation devices
US6995013B2 (en) 2002-07-08 2006-02-07 Biomed Solutions, Llc Cell-scaffold composition containing five layers
US20060030948A1 (en) 2000-07-19 2006-02-09 Albert Manrique Osteoimplant and method of making same
US7009039B2 (en) 2001-07-19 2006-03-07 Prochon Biotech Ltd. Plasma protein matrices and methods for their preparation
US20060060209A1 (en) 2004-09-23 2006-03-23 Shepard David O Osteochondral repair using plug fashioned from partial distal allograft femur or condyle
US7018416B2 (en) 2000-07-06 2006-03-28 Zimmer Spine, Inc. Bone implants and methods
WO2006036681A2 (en) 2004-09-22 2006-04-06 Cartilix, Inc. Cartilage filling device
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
WO2006050213A2 (en) 2004-10-29 2006-05-11 Michalow Alexander E Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway
US20060099234A1 (en) 2002-12-05 2006-05-11 Heinz Winkler Implant containing cultured cartilage cells and method for producing this implant
US7048765B1 (en) 1997-08-27 2006-05-23 Regeneration Technologies, Inc. Intervertebral spacers
US7048762B1 (en) 1997-08-27 2006-05-23 Regeneration Technologies, Inc. Elongated cortical bone implant
US7070942B2 (en) 1998-10-14 2006-07-04 Depuy Spine, Inc. Method of inducing or enhancing chondrogenesis with extracellular matrix containing GDF-5
US7078232B2 (en) 1999-08-19 2006-07-18 Artecel, Inc. Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof
US7087082B2 (en) 1998-08-03 2006-08-08 Synthes (Usa) Bone implants with central chambers
US20060178748A1 (en) 2004-02-05 2006-08-10 Dinger Fred B Iii Implants and delivery system for treating defects in articulating surfaces
US7108721B2 (en) 2000-05-11 2006-09-19 Massachusetts Institute Of Technology Tissue regrafting
US20060216323A1 (en) 2003-02-04 2006-09-28 David Knaack Polyurethanes for osteoimplants
USRE39321E1 (en) 1990-11-27 2006-10-03 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US20060235534A1 (en) 2005-04-15 2006-10-19 Gertzman Arthur A Vertebral disc repair
US20060247790A1 (en) 2005-04-30 2006-11-02 Mckay William F Shaped osteochondral grafts and methods of using same
US20060247791A1 (en) 2005-04-29 2006-11-02 Mckay William F Multi-purpose medical implant devices
US7132110B2 (en) 2001-08-30 2006-11-07 Isotis Orthobiologics, Inc. Tissue repair compositions and methods for their manufacture and use
EP1719463A1 (en) 1999-12-03 2006-11-08 University Of Leeds Repair of damaged tissue
US20060251631A1 (en) 2005-05-05 2006-11-09 Isto Technologies, Inc. Treatment of joint disease, methods and apparatuses therefor
US7141072B2 (en) 1998-10-05 2006-11-28 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damaged joint using multi-layer covering
US20060293757A1 (en) 2005-06-22 2006-12-28 Mckay William F Osteograft treatment to promote osteoinduction and osteograft incorporation
US7157428B2 (en) 2003-11-26 2007-01-02 Histogenics, Corp. Method for treatment and repair of meniscal injuries
US20070009610A1 (en) 2005-07-11 2007-01-11 Carina Syring Engineered osteochondral construct for treatment of articular cartilage defects
US20070014867A1 (en) 2003-08-20 2007-01-18 Histogenics Corp Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and a method for use thereof
US20070026030A1 (en) 2005-07-27 2007-02-01 Berkeley Advanced Biomaterials, Inc. Method of preparing rheological materials for bone and cartilage repair
US20070036834A1 (en) 2001-08-29 2007-02-15 Pauletti Giovanni M Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome P450 enzymes and membrane efflux systems following vaginal and oral cavity administration
US20070041950A1 (en) 2005-02-01 2007-02-22 Osteobiologics, Inc. Method and device for selective addition of a bioactive agent to a multi-phase implant
US7182781B1 (en) 2000-03-02 2007-02-27 Regeneration Technologies, Inc. Cervical tapered dowel
US20070055377A1 (en) 2001-02-16 2007-03-08 Zimmer Spine, Inc. Bone implants and methods
US20070067032A1 (en) 2003-06-27 2007-03-22 Felt Jeffrey C Meniscus preserving implant method and apparatus
US20070065943A1 (en) 2005-09-19 2007-03-22 Histogenics Corp. Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US20070083266A1 (en) 2001-05-25 2007-04-12 Vertegen, Inc. Devices and methods for treating facet joints, uncovertebral joints, costovertebral joints and other joints
USRE39587E1 (en) 1998-02-27 2007-04-24 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US20070093912A1 (en) 2005-10-25 2007-04-26 Mark Borden Porous and nonporous materials for tissue grafting and repair
US20070093896A1 (en) 2005-10-26 2007-04-26 Malinin Theodore I Method and instrumentation for the preparation and transplantation of osteochondral allografts
US20070100450A1 (en) 2005-11-02 2007-05-03 Zimmer Technology, Inc. Joint spacer implant
US20070113951A1 (en) 2005-11-07 2007-05-24 National Tsing Hua University Osteochondral composite scaffold for articular cartilage repair and preparation thereof
US7226482B2 (en) 2003-09-02 2007-06-05 Synthes (U.S.A.) Multipiece allograft implant
US20070128155A1 (en) 2005-12-07 2007-06-07 Isto Technologies, Inc. Cartilage repair methods
US20070134291A1 (en) 1999-10-05 2007-06-14 Kang Ting Composition for cartilage
US20070162121A1 (en) 2006-01-12 2007-07-12 Tarrant Laurence J Method for repair and reconstruction of ruptured ligaments or tendons and for treatment of ligament and tendon injuries
US20070172506A1 (en) 2006-01-25 2007-07-26 Sdgi Holdings, Inc. Osteochondral implant procedure
US20070179607A1 (en) 2006-01-31 2007-08-02 Zimmer Technology, Inc. Cartilage resurfacing implant
US7252987B2 (en) 2001-12-06 2007-08-07 Islet Technology, Inc. System for analysis and selection of encapsulated cellular materials
US20070185585A1 (en) 2004-03-09 2007-08-09 Brat Bracy Implant Scaffold Combined With Autologous Tissue, Allogenic Tissue, Cultured Tissue, or combinations Thereof
US7264634B2 (en) 2002-09-20 2007-09-04 Arthrex, Inc. Method and instrumentation for osteochondral repair using preformed implants
US7273756B2 (en) 2004-10-01 2007-09-25 Isto Technologies, Inc. Method for chondrocyte expansion with phenotype retention
US7288406B2 (en) 2000-10-31 2007-10-30 Prochon Biotech Ltd. Active variants of FGF with improved specificity
US7291169B2 (en) 2005-04-15 2007-11-06 Zimmer Technology, Inc. Cartilage implant
US7297161B2 (en) 1999-05-10 2007-11-20 Fell Barry M Surgically implantable knee prosthesis
US20070276506A1 (en) 2006-05-25 2007-11-29 Biomet Manufacturing Corp. Demineralized osteochondral plug
US20070299517A1 (en) 2006-06-21 2007-12-27 Howmedica Osteonics Corp. Articular cartilage implant
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7323011B2 (en) 2002-10-18 2008-01-29 Musculoskeletal Transplant Foundation Cortical and cancellous allograft cervical fusion block
US20080027546A1 (en) 2006-07-25 2008-01-31 Semler Eric J Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
US20080031915A1 (en) 2004-05-21 2008-02-07 Jose Becerra Ratia Cartilage and Bone Repair Composition
US20080039955A1 (en) 2001-01-30 2008-02-14 Hunziker Ernst B Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial-derived tissue or cells
US20080039954A1 (en) 2006-08-08 2008-02-14 Howmedica Osteonics Corp. Expandable cartilage implant
US20080039939A1 (en) 2003-07-31 2008-02-14 Yukihide Iwamoto Method of Constructing Artificial Joint
US7335508B2 (en) 2004-07-22 2008-02-26 Prochon Biotech Ltd. Porous plasma protein matrices and methods for preparation thereof
US7338524B2 (en) 1999-05-10 2008-03-04 Fell Barry M Surgically implantable knee prosthesis
US7338492B2 (en) 2002-05-15 2008-03-04 Linvatec Corporation Cross-pin graft fixation, instruments, and methods
US20080058953A1 (en) 2006-08-31 2008-03-06 Scarborough Nelson L Demineralized cancellous strip DBM graft
US20080065210A1 (en) 2006-09-11 2008-03-13 Mckay William F Multi-phase osteochondral implantable device
US20080077251A1 (en) 1999-06-07 2008-03-27 Chen Silvia S Cleaning and devitalization of cartilage
WO2008038287A2 (en) 2006-09-28 2008-04-03 Hepacore Ltd. N-terminal fgf variants having increased receptor selectivity and uses thereof
US7365051B2 (en) 1996-11-19 2008-04-29 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Compounds with improved cartilage-inducing and/or bone-inducing activity
US7371400B2 (en) 2001-01-02 2008-05-13 The General Hospital Corporation Multilayer device for tissue engineering
US20080119947A1 (en) 2006-11-18 2008-05-22 Smith & Nephew, Inc. Annular Ring Implant
US20080125868A1 (en) 2004-12-13 2008-05-29 Rickard Branemark Implant And An Implant Member
US20080125863A1 (en) 2006-11-28 2008-05-29 Mckay William F Implant designs and methods of improving cartilage repair
US20080138414A1 (en) 2006-12-08 2008-06-12 Smith & Nephew, Inc. Methods of Regenerating Cartilage
US20080154372A1 (en) 2006-12-21 2008-06-26 Peckham Steven M Osteochondral implant using a growth factor concentration gradient for repair of bone and cartilage tissue
US20080153157A1 (en) 2006-12-20 2008-06-26 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
WO2008081463A2 (en) 2007-01-04 2008-07-10 Hepacore Ltd. Water soluble reactive derivatives of carboxy polysaccharides and fibrinogen conjugates thereof
US7416889B2 (en) 2006-04-27 2008-08-26 Rhode Island Hospital Methods and compositions for repairing cartilage
WO2008106254A2 (en) 2007-01-24 2008-09-04 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20080220044A1 (en) 2007-03-06 2008-09-11 Semler Eric J Cancellous construct with support ring for repair of osteochondral defects
US20080249632A1 (en) 2007-02-26 2008-10-09 Biomet Sports Medicine, Inc. Stable cartilage defect repair plug
US20080294270A1 (en) 2007-05-24 2008-11-27 Zimmer Orthobiologics, Inc. Differentially processed tissue and processing methods thereof
US20080305145A1 (en) 2007-06-01 2008-12-11 Bacterin International, Inc. Process for demineralization of bone matrix with preservation of natural growth factors
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
US7476257B2 (en) 2001-09-15 2009-01-13 Rush University Medical Center Methods to engineer stratified cartilage tissue
US20090024224A1 (en) 2007-07-16 2009-01-22 Chen Silvia S Implantation of cartilage
US7485310B2 (en) 2003-08-12 2009-02-03 Tigenix N.V. Use of CXCL6 chemokine in the prevention or repair of cartilage defects
US20090069904A1 (en) 2007-09-12 2009-03-12 Applied Medical Research Biomaterial including micropores
US20090076624A1 (en) 2007-09-14 2009-03-19 Mohamed Naushad Rahaman Synthetic osteochondral composite and method of fabrication thereof
US20090081276A1 (en) 2007-08-13 2009-03-26 Eben Alsberg Bioresorbable implant composition
US20090099661A1 (en) 2007-08-14 2009-04-16 Jinia Bhattacharya Multiple component osteoimplant
US20090131986A1 (en) 2007-11-19 2009-05-21 David Lee Method and apparatus for spinal facet joint fusion using irregularly shaped cortical bone implants
US7537780B2 (en) 2002-03-22 2009-05-26 Histogenics Corporation Method for preparing and implanting a cartilage construct to treat cartilage lesions
US7537617B2 (en) 2003-06-05 2009-05-26 Warsaw Orthopedic, Inc. Bone strip implants and method of making same
US20090149893A1 (en) 2007-12-05 2009-06-11 Semler Eric J Cancellous Bone Implant for Cartilage Repair
US7548865B2 (en) 2000-10-20 2009-06-16 Arthrex, Inc. Method of selling procedure specific allografts and associated instrumentation
US7563455B2 (en) 1999-02-04 2009-07-21 Warsaw Orthopedic, Inc. Highly-mineralized osteogenic sponge compositions, and uses thereof
US7563769B2 (en) 2002-05-09 2009-07-21 ProChon Biotech, Ltd. FGF variants and methods for use thereof
US20090210057A1 (en) 2005-12-29 2009-08-20 Chun-Jan Liao Multi-layered implant prepared by a method of tissue repair using a multi-layered matrix
US20090226523A1 (en) 2007-10-19 2009-09-10 Keyvan Behnam Demineralized bone matrix compositions and methods
WO2009111069A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US20090280179A1 (en) 2006-02-09 2009-11-12 Hans-Georg Neumann Resorbable Calcium Phosphate Based Biopolymer-Cross-Linked Bone Replacement Material
US7621963B2 (en) 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
US7622438B1 (en) 2005-07-18 2009-11-24 Acologix, Inc. Protein formulation for promoting hard tissue formation
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US20090291112A1 (en) 2003-05-16 2009-11-26 Truncale Katherine G Allograft osteochondral plug combined with cartilage particle mixture
US20090299475A1 (en) 2008-06-03 2009-12-03 Gc Corporation Bone graft substitute
US7628851B2 (en) 2003-09-05 2009-12-08 Synthes Usa, Llc Bone cement compositions having fiber-reinforcement and/or increased flowability
US7632311B2 (en) 2003-10-28 2009-12-15 Xiros Plc Repair of damaged tissue on a bone site
US20090312842A1 (en) 2008-06-16 2009-12-17 Predrag Bursac Assembled Cartilage Repair Graft
US20090319051A9 (en) 2005-12-07 2009-12-24 Nycz Jeffrey H Osteochondral plug graft, kit and method
US7648700B2 (en) 2004-05-14 2010-01-19 Unigene Laboratories, Inc. Method for fostering bone formation and preservation
US7648965B2 (en) 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US20100015202A1 (en) 2007-03-06 2010-01-21 Semler Eric J Cancellous construct with support ring for repair of osteochondral defects
US20100021521A1 (en) 2008-07-22 2010-01-28 Guo-Feng Xu Prosthesis for joint cartilage repair and method of manufacture
US7658768B2 (en) 2002-06-24 2010-02-09 Wright Medical Technology, Inc. Bone graft substitute composition
US20100036503A1 (en) 2008-08-07 2010-02-11 Chen Silvia S Composition for a Tissue Repair Implant and Methods of Making the Same
US20100036492A1 (en) 2008-07-06 2010-02-11 The Curators Of The University Of Missouri Osteochondral implants, arthroplasty methods, devices, and systems
US7666230B2 (en) 2003-12-08 2010-02-23 Depuy Products, Inc. Implant device for cartilage regeneration in load bearing articulation regions
WO2010083051A2 (en) 2009-01-15 2010-07-22 ProChon Biotech, Ltd. Cartilage particle tissue mixtures optionally combined with a cancellous construct
US7824701B2 (en) 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US20110104242A1 (en) 2007-05-10 2011-05-05 Malinin Theodore I Cartilage material

Patent Citations (687)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6183737B2 (en)
US6180605B2 (en)
US3400199A (en) 1965-02-26 1968-09-03 Leslie L. Balassa Wound-healing cartilage powder
US3476855A (en) 1965-02-26 1969-11-04 Leslie L Balassa Sterilizing and enhancing activity of a finely divided cartilage powder
US3478146A (en) 1965-02-26 1969-11-11 Leslie L Balassa Wound-healing cartilage powder extracting process
US3551560A (en) 1967-10-02 1970-12-29 Heinrich F Thiele Process of reconstructing tendons,cartilage,nerve sheaths,and products
US3772432A (en) 1971-01-11 1973-11-13 Lescarden Ltd Cartilage compositions for dental use
US3867728A (en) 1971-12-30 1975-02-25 Cutter Lab Prosthesis for spinal repair
US3966908A (en) 1973-11-29 1976-06-29 Lescarden Ltd. Method of treating degenerative joint afflictions
US4172128A (en) 1975-03-26 1979-10-23 Erhard Thiele Process of degrading and regenerating bone and tooth material and products
US4060081A (en) 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
US4201845A (en) 1976-04-12 1980-05-06 Monsanto Company Cell culture reactor
US4296100A (en) 1980-06-30 1981-10-20 Franco Wayne P Method of treating the heart for myocardial infarction
US4378347A (en) 1980-06-30 1983-03-29 Franco Wayne P Composition for treating the heart for myocardial infarction
US4400833A (en) 1981-06-10 1983-08-30 Kurland Kenneth Z Means and method of implanting bioprosthetics
US4442655A (en) 1981-06-25 1984-04-17 Serapharm Michael Stroetmann Fibrinogen-containing dry preparation, manufacture and use thereof
GB2102811B (en) 1981-07-28 1985-01-30 Immuno Ag A tissue adhesive and a method of producing the same
US4394370A (en) 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4458678A (en) 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
US4479271A (en) 1981-10-26 1984-10-30 Zimmer, Inc. Prosthetic device adapted to promote bone/tissue ingrowth
US4505266A (en) 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
US4501269A (en) 1981-12-11 1985-02-26 Washington State University Research Foundation, Inc. Process for fusing bone joints
US4642120A (en) 1983-03-23 1987-02-10 Ramot University Authority For Applied Research And Industrial Development Ltd. Repair of cartilage and bones
US4801299A (en) 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US4932973A (en) 1983-09-30 1990-06-12 El Gendler Cartilage and bone induction by artificially perforated organic bone matrix
US5155214A (en) 1984-03-05 1992-10-13 The Salk Institute For Biological Studies Basic fibroblast growth factor
US4609551A (en) 1984-03-20 1986-09-02 Arnold Caplan Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
US4600574A (en) 1984-03-21 1986-07-15 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Method of producing a tissue adhesive
US4757017A (en) 1984-09-14 1988-07-12 Mcw Research Foundation, Inc. In vitro cell culture system
US4976738A (en) 1985-01-09 1990-12-11 Sulzer Brothers Limited Porous metal overlay for an implant surface
US4978355A (en) 1985-01-25 1990-12-18 Sulzer Brothers Limited Plastic bone implant having a reinforced contact surface
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683202B1 (en) 1985-03-28 1990-11-27 Cetus Corp
US4795467A (en) 1985-03-28 1989-01-03 Collagen Corporation Xenogeneic collagen/mineral preparations in bone repair
US5053049A (en) 1985-05-29 1991-10-01 Baxter International Flexible prostheses of predetermined shapes and process for making same
US4627853A (en) 1985-05-29 1986-12-09 American Hospital Supply Corporation Method of producing prostheses for replacement of articular cartilage and prostheses so produced
US4681763A (en) 1985-06-11 1987-07-21 University Of Medicine And Dentistry Of New Jersey Composition for stimulating bone growth
US5266476A (en) 1985-06-18 1993-11-30 Yeda Research & Development Co., Ltd. Fibrous matrix for in vitro cell cultivation
US5002583A (en) 1985-08-13 1991-03-26 Sandu Pitaru Collagen implants
US4656137A (en) 1985-09-12 1987-04-07 Lescarden Inc Method of processing animal cartilage
US5439818A (en) 1985-09-12 1995-08-08 Scios Nova Inc. DNA encoding human recombinant basic fibroblast growth factor
US5604293A (en) 1985-09-12 1997-02-18 Scios Inc. Recombinant human basic fibroblast growth factor
US6294359B1 (en) 1985-09-12 2001-09-25 Scios Inc. Human basic fibroblast growth factor analog
US4994559A (en) 1985-12-17 1991-02-19 Synergen, Inc. Human basic fibroblast growth factor
US4776173A (en) 1985-12-20 1988-10-11 Angio-Medical Corporation Method for extracting a substance from animal derived material
US6005161A (en) 1986-01-28 1999-12-21 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683195B1 (en) 1986-01-30 1990-11-27 Cetus Corp
US5443950A (en) 1986-04-18 1995-08-22 Advanced Tissue Sciences, Inc. Three-dimensional cell and tissue culture system
US4776853A (en) 1986-07-28 1988-10-11 Hsc Research Development Corporation Process for preparing biological mammalian implants
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5084051A (en) 1986-11-03 1992-01-28 Toermaelae Pertti Layered surgical biocomposite material
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US5770417A (en) 1986-11-20 1998-06-23 Massachusetts Institute Of Technology Children's Medical Center Corporation Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo
US5736372A (en) 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US5002071A (en) 1987-04-03 1991-03-26 Research Development Foundation Injectable soft tissue augmentation materials from the placenta and their method of manufacture
US4963489A (en) 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US4846835A (en) 1987-06-15 1989-07-11 Grande Daniel A Technique for healing lesions in cartilage
US5007934A (en) 1987-07-20 1991-04-16 Regen Corporation Prosthetic meniscus
US5624463A (en) 1987-07-20 1997-04-29 Regen Biologics, Inc. Prosthetic articular cartilage
US5681353A (en) 1987-07-20 1997-10-28 Regen Biologics, Inc. Meniscal augmentation device
US5306311A (en) 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US4880429A (en) 1987-07-20 1989-11-14 Stone Kevin R Prosthetic meniscus
US5260420A (en) 1987-07-30 1993-11-09 Centre Regional De Transfusion Sanguine De Lille Concentrate of thrombin coagulable proteins, the method of obtaining same and therapeutical use thereof
US4950296A (en) 1988-04-07 1990-08-21 Mcintyre Jonathan L Bone grafting units
US5354557A (en) 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US4955911A (en) 1988-04-21 1990-09-11 Sulzer Brothers Limited Bone implant
US5053050A (en) 1988-04-29 1991-10-01 Samuel Itay Compositions for repair of cartilage and bone
US4904259A (en) 1988-04-29 1990-02-27 Samuel Itay Compositions and methods for repair of cartilage and bone
US4837379A (en) 1988-06-02 1989-06-06 Organogenesis Inc. Fibrin-collagen tissue equivalents and methods for preparation thereof
US5496722A (en) 1988-06-30 1996-03-05 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method for producing non-neoplastic, three dimensional, mammalian tissue and cell aggregates under microgravity culture conditions and the products produced therefrom
US4950483A (en) 1988-06-30 1990-08-21 Collagen Corporation Collagen wound healing matrices and process for their production
US5859208A (en) 1988-07-06 1999-01-12 Fiddes; John C. Human basic fibroblast growth factor analog
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US5032508A (en) 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US4971954A (en) 1988-11-23 1990-11-20 University Of Medicine And Dentistry Of New Jersey Collagen-based matrices ribose cross-linked
US4963146A (en) 1989-04-20 1990-10-16 Colla-Tec Incorporated Multi-layered, semi-permeable conduit for nerve regeneration
US5576288A (en) 1989-04-27 1996-11-19 The Salk Institute For Biological Studies Fibroblast growth factor conjugates
US5191067A (en) 1989-04-27 1993-03-02 The Salk Institute For Biological Studies Fibroblast growth factor conjugates
US5679637A (en) 1989-04-27 1997-10-21 The Salk Institute For Biological Studies Fibroblast growth factor conjugates
US4994084A (en) 1989-06-23 1991-02-19 Brennan H George Reconstructive surgery method and implant
US5298254A (en) 1989-09-21 1994-03-29 Osteotech, Inc. Shaped, swollen demineralized bone and its use in bone repair
US5073373A (en) 1989-09-21 1991-12-17 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5290558A (en) 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5439684A (en) 1989-09-21 1995-08-08 Osteotech, Inc. Shaped, swollen demineralized bone and its use in bone repair
US5236456A (en) 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5152791A (en) 1989-12-07 1992-10-06 Olympus Optical Co., Ltd. Prosthetic artificial bone having ceramic layers of different porosity
US5067964A (en) 1989-12-13 1991-11-26 Stryker Corporation Articular surface repair
US5118512A (en) 1990-01-23 1992-06-02 Osteotech, Inc. (A Delaware Corp.) Process for cryopreserving biological materials and materials prepared thereby
US5425769A (en) 1990-04-23 1995-06-20 Snyders, Jr.; Robert V. Composition of material for osseous repair
US5195892A (en) 1990-07-23 1993-03-23 Odontit S.A. Bone-integrated dental implant system
US5067963A (en) 1990-08-21 1991-11-26 Washington University Method of making live autogenous skeletal replacement parts
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
US5306304A (en) 1990-10-31 1994-04-26 El Gendler Flexible membranes produced from organic bone matrix for skeletal repair and reconstruction
US5464439A (en) 1990-10-31 1995-11-07 Gendler; El Flexible membranes produced from organic bone matrix for skeletal repair and reconstruction
US5556430A (en) 1990-10-31 1996-09-17 Gendler; El Flexible membranes produced from organic bone matrix for skeletal repair and reconstruction
US5226914A (en) 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5302702A (en) 1990-11-23 1994-04-12 American Cyanamid Company Chimeric fibroblast growth factors
US5310883A (en) 1990-11-23 1994-05-10 American Cyanamid Company Chimeric fibroblast growth factors
USRE39321E1 (en) 1990-11-27 2006-10-03 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US5569272A (en) 1991-01-31 1996-10-29 Carnegie Mellon University Tissue-connective devices with micromechanical barbs
US5206023A (en) 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5368858A (en) 1991-01-31 1994-11-29 Robert F. Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage
US5853746A (en) 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
US5512460A (en) 1991-02-14 1996-04-30 Takeda Chemical Industries, Ldt Glia activating factor and its production
US5622928A (en) 1991-02-14 1997-04-22 Takeda Chemical Industries, Ltd. Glia activation factor and its production
US5863296A (en) 1991-03-05 1999-01-26 Colorado State University Research Foundation Treated tissue for implantation and methods of treatment and use
EP0517030B1 (en) 1991-06-04 1996-09-04 MAN Ceramics GmbH Vertebral implant
EP0517030A2 (en) 1991-06-04 1992-12-09 MAN Ceramics GmbH Vertebral implant
US6440427B1 (en) 1991-06-17 2002-08-27 Biovitrum Ab Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer
US5631011A (en) 1991-06-17 1997-05-20 Wadstroem; Jonas Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer
US5338772A (en) 1991-06-20 1994-08-16 Merck Patent Gesellschaft Mit Beschrankter Haftung Implant material
EP0522569A1 (en) 1991-07-12 1993-01-13 United States Surgical Corporation Composition for effecting bone repair
US5356629A (en) 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US5888219A (en) 1991-08-12 1999-03-30 Bonutti; Peter M. Method of using human tissue with a tissue press and system
US6630000B1 (en) 1991-08-12 2003-10-07 Bonutti 2003 Trust-A Method of using body tissue
US5545222A (en) 1991-08-12 1996-08-13 Bonutti; Peter M. Method using human tissue
US5092887A (en) 1991-08-12 1992-03-03 El Gendler Artificial ligament produced from demineralized bone for the replacement and augmentation of ligaments, tendons and other fibrous connective tissue
US5662710A (en) 1991-08-12 1997-09-02 Bonutti; Peter M. Tissue press method of use
US6361565B1 (en) 1991-08-12 2002-03-26 Peter M. Bonutti Expandable hip implant
US6132472A (en) 1991-08-12 2000-10-17 Bonutti; Peter M. Tissue press and system
US6503277B2 (en) 1991-08-12 2003-01-07 Peter M. Bonutti Method of transplanting human body tissue
US5329846A (en) 1991-08-12 1994-07-19 Bonutti Peter M Tissue press and system
US5270300A (en) 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5445833A (en) 1991-09-24 1995-08-29 Purdue Research Foundation Tendon or ligament graft for promoting autogenous tissue growth
US5372821A (en) 1991-09-24 1994-12-13 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5284155A (en) 1991-12-06 1994-02-08 The General Hospital Corporation Cartilage degradation assay system
US5513662A (en) 1991-12-31 1996-05-07 Osteotech, Inc. Preparation of bone for transplantation
US5314476A (en) 1992-02-04 1994-05-24 Osteotech, Inc. Demineralized bone particles and flowable osteogenic composition containing same
US5510396A (en) 1992-02-04 1996-04-23 Osteotech, Inc. Process for producing flowable osteogenic composition containing demineralized bone particles
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US6013853A (en) 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5607474A (en) 1992-02-14 1997-03-04 Board Of Regents, University Of Texas System Multi-phase bioerodible implant/carrier and method of manufacturing and using same
US5326357A (en) 1992-03-18 1994-07-05 Mount Sinai Hospital Corporation Reconstituted cartridge tissue
US5466462A (en) 1992-03-25 1995-11-14 Johnson & Johnson Medical, Inc. Heteromorphic sponges containing active agents
US5700476A (en) 1992-03-25 1997-12-23 Johnson & Johnson Medical, Inc. Heteromorphic sponges containing active agents
US5256140A (en) 1992-03-27 1993-10-26 Fallien Cosmeceuticals, Ltd. Composition for levelling skin
US5893888A (en) 1992-08-07 1999-04-13 Tissue Engineering, Inc. Method and construct for producing graft tissue from extracellular matrix
US5800537A (en) 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5352463A (en) 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
US5516533A (en) 1992-11-13 1996-05-14 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5571895A (en) 1992-12-22 1996-11-05 Takeda Chemical Industries, Ltd. Modified GAF polypeptides
US5549904A (en) 1993-06-03 1996-08-27 Orthogene, Inc. Biological adhesive composition and method of promoting adhesion between tissue surfaces
US5736132A (en) 1993-06-03 1998-04-07 Orthogene, Inc. Method of promoting adhesion between tissue surfaces
US5380328A (en) 1993-08-09 1995-01-10 Timesh, Inc. Composite perforated implant structures
US5491220A (en) 1993-09-24 1996-02-13 Yeda Research And Development Co., Ltd. Surface loop structural analogues of fibroblast growth factors
US5507813A (en) 1993-12-09 1996-04-16 Osteotech, Inc. Shaped materials derived from elongate bone particles
US5411885A (en) 1993-12-17 1995-05-02 New York Blood Center, Inc. Methods for tissue embedding and tissue culturing
US5656598A (en) 1994-03-08 1997-08-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Use of fibroblast growth factors to stimulate bone growth
US5614496A (en) 1994-03-08 1997-03-25 Osteosa Inc. Use of fibroblast growth factors to stimulate bone growth
US5899936A (en) 1994-03-14 1999-05-04 Cryolife, Inc. Treated tissue for implantation and methods of preparation
US5916265A (en) 1994-03-30 1999-06-29 Hu; Jie Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant
US6025334A (en) 1994-04-28 2000-02-15 Les Laboratoires Aeterna Inc. Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof
US5618925A (en) 1994-04-28 1997-04-08 Les Laboratories Aeterna Inc. Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof
US5723331A (en) 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US5786217A (en) 1994-05-05 1998-07-28 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US6306177B1 (en) 1994-05-06 2001-10-23 Advanced Bio Surfaces, Inc. Biomaterial system for in situ tissue repair
US20050074481A1 (en) 1994-05-13 2005-04-07 Brekke John H. Device for regeneration of articular cartilage and other tissue
EP0762903B1 (en) 1994-06-03 2003-09-17 Stryker Corporation Manufacture of autogenous replacement body parts
EP0762903B2 (en) 1994-06-03 2007-08-22 Stryker Corporation Manufacture of autogenous replacement body parts
EP0762903A1 (en) 1994-06-03 1997-03-19 Creative Biomolecules, Inc. Manufacture of autogenous replacement body parts
US20050089544A1 (en) 1994-06-03 2005-04-28 Khouri Roger K. Manufacture of autogenous replacement body parts
US6110482A (en) 1994-06-03 2000-08-29 Styker Corporation Manufacture of autogenous replacement body parts
US6027743A (en) 1994-06-03 2000-02-22 Stryker Corporation Manufacture of autogenous replacement body parts
US5906827A (en) 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
US5955438A (en) 1994-07-19 1999-09-21 Colbar R & D Ltd. Collagen-based matrix
US5968556A (en) 1994-08-05 1999-10-19 Children's Medical Center Corp. Injectable non-immunogenic cartilage and bone preparation
US5516532A (en) 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5769899A (en) 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
US5707962A (en) 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
US6180605B1 (en) 1994-09-28 2001-01-30 Gensci Orthobiologics, Inc. Composition with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
EP0784985A1 (en) 1994-09-30 1997-07-23 Yamanouchi Pharmaceutical Co. Ltd. Osteoplastic graft
US7220558B2 (en) 1994-11-07 2007-05-22 The United States Of America As Represented By The Department Of Health And Human Services Cartilage-derived morphogenetic proteins
US5948429A (en) 1994-11-22 1999-09-07 Tissue Engineering, Inc. Methods for preparing biopolymer foams
US5891558A (en) 1994-11-22 1999-04-06 Tissue Engineering, Inc. Biopolymer foams for use in tissue repair and reconstruction
US6599515B1 (en) 1995-01-16 2003-07-29 Baxter International Inc. Fibrin porous structure
US6074663A (en) 1995-01-16 2000-06-13 Baxter International Inc. Method of using cross-linked fibrin material
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5632745A (en) 1995-02-07 1997-05-27 R&D Biologicals, Inc. Surgical implantation of cartilage repair unit
US5749874A (en) 1995-02-07 1998-05-12 Matrix Biotechnologies, Inc. Cartilage repair unit and method of assembling same
US5713374A (en) 1995-02-10 1998-02-03 The Hospital For Joint Diseases Orthopaedic Institute Fixation method for the attachment of wound repair materials to cartilage defects
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US6080194A (en) 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
US5782835A (en) 1995-03-07 1998-07-21 Innovasive Devices, Inc. Apparatus and methods for articular cartilage defect repair
US6017348A (en) 1995-03-07 2000-01-25 Innovasive Devices, Inc. Apparatus and methods for articular cartilage defect repair
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
US5733337A (en) 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
US5855620A (en) 1995-04-19 1999-01-05 St. Jude Medical, Inc. Matrix substrate for a viable body tissue-derived prosthesis and method for making the same
US5904716A (en) 1995-04-26 1999-05-18 Gendler; El Method for reconstituting cartilage tissue using demineralized bone and product thereof
EP0739631B1 (en) 1995-04-26 2003-03-12 Family Limited Partnership Gendler Laminar bone support for cartilage growth
EP0739631A2 (en) 1995-04-26 1996-10-30 El Gendler Laminar bone support for cartilage growth
US6060640A (en) 1995-05-19 2000-05-09 Baxter International Inc. Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue
US6504079B2 (en) 1995-06-07 2003-01-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US6039762A (en) 1995-06-07 2000-03-21 Sdgi Holdings, Inc. Reinforced bone graft substitutes
US5782915A (en) 1995-09-15 1998-07-21 Stone; Kevin R. Articular cartilage heterografts
US6037171A (en) 1995-10-06 2000-03-14 Microcloning Cccd Ab Cell culture microchambers in a grid matrix sandwiched between a planar base and semipermeable membrane
US6156068A (en) 1995-10-11 2000-12-05 Osteobiologics, Inc. Method of resurfacing a femoral condyle
US5716413A (en) 1995-10-11 1998-02-10 Osteobiologics, Inc. Moldable, hand-shapable biodegradable implant material
US5863297A (en) 1995-10-11 1999-01-26 Osteobiologics, Inc. Moldable, hand-shapable biodegradable implant material
US5989289A (en) 1995-10-16 1999-11-23 Sdgi Holdings, Inc. Bone grafts
US20050004672A1 (en) 1995-10-16 2005-01-06 John Pafford Bone grafts
US20020111695A1 (en) 1995-11-06 2002-08-15 Mount Sinai Hospital Corporation Reconstituted mineralized cartilage tissue
US6231607B1 (en) 1995-12-21 2001-05-15 Hadasit Medical Research Services & Development Company Ltd. Bone graft substitute and its preparation
US6096081A (en) 1996-01-16 2000-08-01 University Of Florida Tissue Bank, Inc. Diaphysial cortical dowel
US5814084A (en) 1996-01-16 1998-09-29 University Of Florida Tissue Bank, Inc. Diaphysial cortical dowel
US6475175B1 (en) 1996-01-31 2002-11-05 John Rivera Method and apparatus for sequestering platelet rich plasma
US5842477A (en) 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US6352558B1 (en) 1996-02-22 2002-03-05 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damage joint
US6221854B1 (en) 1996-03-05 2001-04-24 Orquest, Inc. Method of promoting bone growth with hyaluronic acid and growth factors
US5700774A (en) 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
US5846931A (en) 1996-03-26 1998-12-08 Hattersley; Gary Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide and methods of inducing cartilage by administration of same
US5922028A (en) 1996-04-05 1999-07-13 Depuy Orthopaedics, Inc. Multi-layered SIS tissue graft construct for replacement of cartilaginous elements in situ
US5788625A (en) 1996-04-05 1998-08-04 Depuy Orthopaedics, Inc. Method of making reconstructive SIS structure for cartilaginous elements in situ
US6176880B1 (en) 1996-04-05 2001-01-23 Depuy Orthopaedics, Inc. Tissue graft construct for replacement of cartilaginous structures
US5755791A (en) 1996-04-05 1998-05-26 Purdue Research Foundation Perforated submucosal tissue graft constructs
US6541024B1 (en) 1996-04-19 2003-04-01 Osiris Therapeutics, Inc. Regeneration and augmentation of bone using mesenchymal stem cells
US6242247B1 (en) 1996-06-04 2001-06-05 Sulzer Orthopedics Ltd. Method for making cartilage and implants
US6387693B2 (en) 1996-06-04 2002-05-14 Sulzer Orthopedics Ltd. Method for producing cartilage tissue and implants for repairing enchondral and osteochondral defects as well as arrangement for carrying out the method
US6280473B1 (en) 1996-08-19 2001-08-28 Macropore, Inc. Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration
US20020099448A1 (en) 1996-08-23 2002-07-25 Michael C. Hiles Multi-formed collagenous biomaterial medical device
US6666892B2 (en) 1996-08-23 2003-12-23 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
US6569172B2 (en) 1996-08-30 2003-05-27 Verigen Transplantation Service International (Vtsi) Method, instruments, and kit for autologous transplantation
US20060167483A1 (en) 1996-08-30 2006-07-27 Verigen Ag Method, instruments, and kit for autologous transplantation
US7048750B2 (en) 1996-08-30 2006-05-23 Verigen Ag Method, instruments, and kits for autologous transplantation
US6599300B2 (en) 1996-08-30 2003-07-29 Verigen Transplantation Service International (Vtsi) Method, instruments, and kit for autologous transplantation
US6599301B2 (en) 1996-08-30 2003-07-29 Verrgen Transplantation Service International (Vtsi) Method, instruments, and kit for autologous transplantation
US6592598B2 (en) 1996-08-30 2003-07-15 Verigen Transplantation Service International (Vtsi) Method, instruments, and kit for autologous transplantation
US6592599B2 (en) 1996-08-30 2003-07-15 Verigen Transplantation Service International (Vtsi) Method, instruments, and kit for autologous transplantation
US5759190A (en) 1996-08-30 1998-06-02 Vts Holdings Limited Method and kit for autologous transplantation
US5989269A (en) 1996-08-30 1999-11-23 Vts Holdings L.L.C. Method, instruments and kit for autologous transplantation
EP1181908B1 (en) 1996-08-30 2003-12-17 Verigen Transplantation Service International (VTSI) AG Support for chondrocyte transplantation in cartilage and joint repair
EP1181908A1 (en) 1996-08-30 2002-02-27 VTS Holdings, Ltd. Method, instruments and kit for autologous transplantation
EP1384452A1 (en) 1996-08-30 2004-01-28 Verigen Transplantation Service International (VTSI) AG Method, instruments and kit for autologous transplantation
US7137989B2 (en) 1996-08-30 2006-11-21 Verigen Ag Method, instruments, and kit for autologous transplantation
US6379367B1 (en) 1996-08-30 2002-04-30 Verigen Transplantation Service International (Vtsi) Ag Method instruments and kit for autologous transplantation
US6283980B1 (en) 1996-08-30 2001-09-04 Verigen Transplantation Services Internt'l Method, instruments, and kit for autologous transplantation
US6305379B1 (en) 1996-09-06 2001-10-23 Lifenet Process for producing osteoinductive bone, and osteoinductive bone produced thereby
US6189537B1 (en) 1996-09-06 2001-02-20 Lifenet Process for producing osteoinductive bone, and osteoinductive bone produced thereby
US5881733A (en) 1996-09-13 1999-03-16 Depuy Orthopaedic Technology, Inc. Technique for osteocartilaginous transplantation in a mammalian joint
US6165487A (en) 1996-09-30 2000-12-26 Children's Medical Center Corporation Methods and compositions for programming an organic matrix for remodeling into a target tissue
US5989866A (en) 1996-10-16 1999-11-23 Zymogenetics, Inc. FGF homologs
US6352971B1 (en) 1996-10-16 2002-03-05 Zymogenetics, Inc. FGF Homologs
US5974663A (en) 1996-10-25 1999-11-02 Honda Giken Kogya Kabushiki Kaisha Method of manufacturing connecting rod
US6096347A (en) 1996-11-05 2000-08-01 Purdue Research Foundation Myocardial graft constructs
US7365051B2 (en) 1996-11-19 2008-04-29 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Compounds with improved cartilage-inducing and/or bone-inducing activity
US5728159A (en) 1997-01-02 1998-03-17 Musculoskeletal Transplant Foundation Serrated bone graft
US5972385A (en) 1997-01-15 1999-10-26 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
US6281195B1 (en) 1997-02-07 2001-08-28 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US6146385A (en) 1997-02-11 2000-11-14 Smith & Nephew, Inc. Repairing cartilage
US5964805A (en) 1997-02-12 1999-10-12 Stone; Kevin R. Method and paste for articular cartilage transplantation
EP0968012B1 (en) 1997-03-20 2006-09-06 Stryker Corporation Osteogenic devices and methods of use thereof for repair of bone
EP1719531A2 (en) 1997-03-20 2006-11-08 Stryker Corporation Osteogenic devices and methods of use thereof for repair of bones
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
EP1719532A2 (en) 1997-03-20 2006-11-08 Stryker Corporation Osteogenic devices and methods of use thereof for repair of bones
US5866415A (en) 1997-03-25 1999-02-02 Villeneuve; Peter E. Materials for healing cartilage and bone defects
US6001352A (en) 1997-03-31 1999-12-14 Osteobiologics, Inc. Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor
US6235316B1 (en) 1997-04-04 2001-05-22 Barnes-Jewish Hospital Neocartilage and methods of use
US7087227B2 (en) 1997-04-04 2006-08-08 Barnes-Jewish Hospital Cartilage composites and methods of use
US6783712B2 (en) 1997-05-30 2004-08-31 Osteobiologics, Inc. Fiber-reinforced, porous, biodegradable implant device
US20050240281A1 (en) 1997-05-30 2005-10-27 Slivka Michael A Fiber-reinforced, porous, biodegradable implant device
US6511511B1 (en) 1997-05-30 2003-01-28 Osteobiologics, Inc. Fiber-reinforced, porous, biodegradable implant device
US5972368A (en) 1997-06-11 1999-10-26 Sdgi Holdings, Inc. Bone graft composites and spacers
US6261586B1 (en) 1997-06-11 2001-07-17 Sdgi Holdings, Inc. Bone graft composites and spacers
US6303585B1 (en) 1997-07-03 2001-10-16 Orquest, Inc. Cross-linked polysaccharide drug carrier
US5910315A (en) 1997-07-18 1999-06-08 Stevenson; Sharon Allograft tissue material for filling spinal fusion cages or related surgical spaces
US20010011131A1 (en) 1997-07-28 2001-08-02 Luyten Frank P. DNA molecules encoding cartilage-derived morphogenetic proteins
US6471993B1 (en) 1997-08-01 2002-10-29 Massachusetts Institute Of Technology Three-dimensional polymer matrices
US6090996A (en) 1997-08-04 2000-07-18 Collagen Matrix, Inc. Implant matrix
US6110209A (en) 1997-08-07 2000-08-29 Stone; Kevin R. Method and paste for articular cartilage transplantation
USRE41286E1 (en) 1997-08-14 2010-04-27 Zimmer Orthobiologics, Inc. Compositions for regeneration and repair of cartilage lesions
US6511958B1 (en) 1997-08-14 2003-01-28 Sulzer Biologics, Inc. Compositions for regeneration and repair of cartilage lesions
US6514514B1 (en) 1997-08-14 2003-02-04 Sùlzer Biologics Inc. Device and method for regeneration and repair of cartilage lesions
US20020138143A1 (en) 1997-08-27 2002-09-26 Grooms Jamie M. Cortical bone cervical Smith-Robinson fusion implant
US7048765B1 (en) 1997-08-27 2006-05-23 Regeneration Technologies, Inc. Intervertebral spacers
US7048762B1 (en) 1997-08-27 2006-05-23 Regeneration Technologies, Inc. Elongated cortical bone implant
US6398816B1 (en) 1997-09-04 2002-06-04 North Shore-Long Island Jewish Research Institute Genetic engineering of cells to enhance healing and tissue regeneration
US20030077281A1 (en) 1997-09-16 2003-04-24 Cone Robert E. Immunointeractive molecules and uses therefor
US6548729B1 (en) 1997-09-19 2003-04-15 Baxter Aktiengesellschaft Fibrin sponge
US5998170A (en) 1997-10-03 1999-12-07 Amgen Inc. Polynucleotides encoding hepatocyte-specific members of the FGF family
US6752834B2 (en) 1997-10-10 2004-06-22 Ed Geistlich Soehne Ag Fuer Chemische Industrie Membrane for in guided tissue regeneration
US20010020188A1 (en) 1997-10-27 2001-09-06 Tom Sander Selective uptake of materials by bone implants
US6652592B1 (en) 1997-10-27 2003-11-25 Regeneration Technologies, Inc. Segmentally demineralized bone implant
US6090998A (en) 1997-10-27 2000-07-18 University Of Florida Segmentally demineralized bone implant
US6183737B1 (en) 1997-10-30 2001-02-06 The General Hospital Corporation Bonding of cartilage pieces using isolated chondrocytes and a biological gel
US6274663B1 (en) 1997-10-30 2001-08-14 Showa Denko K.K. Compound resin composition
US20030099620A1 (en) 1997-10-30 2003-05-29 The General Hospital Corporation Bonding of cartilaginous matrices using isolated chondrocytes
US20010006634A1 (en) 1997-10-30 2001-07-05 The General Hospital Corporation Bonding of cartilaginous matrices using isolated chondrocytes
US20010005592A1 (en) 1997-12-12 2001-06-28 Bhatnagar Rajendra S. Chondrocyte-like cells useful for tissue engineering and methods
US6197586B1 (en) 1997-12-12 2001-03-06 The Regents Of The University Of California Chondrocyte-like cells useful for tissue engineering and methods
US6489165B2 (en) 1997-12-12 2002-12-03 The Regents Of The University Of California Chondrocyte-like cells useful for tissue engineering and methods
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
US5899939A (en) 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US6712851B1 (en) 1998-01-23 2004-03-30 Macropore Biosurgery, Inc. Resorbable, macro-porous non-collapsing and flexible membrane barrier for skeletal repair and regeneration
US6319712B1 (en) 1998-01-30 2001-11-20 Deutsche Institute Fur Textil-Und Faserforschung Stuttgart Biohybrid articular surface replacement
US6123731A (en) 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
EP1127581A1 (en) 1998-02-27 2001-08-29 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6911212B2 (en) 1998-02-27 2005-06-28 Musculoskeletal Transplant Foundation Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects
US20040197373A1 (en) 1998-02-27 2004-10-07 Gertzman Arthur A. Composition for filling bone defects
EP1127581B1 (en) 1998-02-27 2005-06-15 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6437018B1 (en) 1998-02-27 2002-08-20 Musculoskeletal Transplant Foundation Malleable paste with high molecular weight buffered carrier for filling bone defects
USRE39587E1 (en) 1998-02-27 2007-04-24 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6030635A (en) 1998-02-27 2000-02-29 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US7045141B2 (en) 1998-02-27 2006-05-16 Musculoskeletal Transplant Foundation Allograft bone composition having a gelatin binder
USRE38522E1 (en) 1998-02-27 2004-05-25 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6458375B1 (en) 1998-02-27 2002-10-01 Musculoskeletal Transplant Foundation Malleable paste with allograft bone reinforcement for filling bone defects
US6056777A (en) 1998-02-27 2000-05-02 Mcdowell; Charles L. Method and device for regenerating cartilage in articulating
US20020192263A1 (en) 1998-02-27 2002-12-19 Merboth Barbara L. Allograft bone composition having a gelatin binder
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US6143293A (en) 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
US20040044408A1 (en) 1998-04-08 2004-03-04 Hungerford David S. Cell-culture and polymer constructs
US7358284B2 (en) 1998-06-19 2008-04-15 Lifecell Corporation Particulate acellular tissue matrix
US20050159822A1 (en) 1998-06-19 2005-07-21 Lifecell Corporation, A Delaware Corporation Particulate acellular tissue matrix
US6933326B1 (en) 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
US6293970B1 (en) 1998-06-30 2001-09-25 Lifenet Plasticized bone and soft tissue grafts and methods of making and using same
US6258778B1 (en) 1998-07-13 2001-07-10 University Of Southern California Methods for accelerating bone and cartilage growth and repair
US7087082B2 (en) 1998-08-03 2006-08-08 Synthes (Usa) Bone implants with central chambers
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
US6398811B1 (en) 1998-08-06 2002-06-04 Sdgi Holdings, Inc. Composited intervertebral bone spacers
US6270528B1 (en) 1998-08-06 2001-08-07 Sdgi Holdings, Inc. Composited intervertebral bone spacers
US20020045940A1 (en) 1998-08-14 2002-04-18 Bruno Giannetti Methods, instruments and materials for chondrocyte cell transplantation
US20050129668A1 (en) 1998-08-14 2005-06-16 Verigen Ag Methods, instruments and materials for chondrocyte cell transplantation
US6866668B2 (en) 1998-08-14 2005-03-15 Verigen Transplantation Service International (“VTSL”) AG Methods, instruments and materials for chondrocyte cell transplantation
US6849255B2 (en) 1998-08-18 2005-02-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods and compositions for enhancing cartilage repair
US20020016592A1 (en) 1998-08-27 2002-02-07 Branch Charles L. Interbody fusion grafts and instrumentation
US20050261681A9 (en) 1998-08-27 2005-11-24 Branch Charles L Interbody fusion grafts and instrumentation
US6530956B1 (en) 1998-09-10 2003-03-11 Kevin A. Mansmann Resorbable scaffolds to promote cartilage regeneration
US6582960B1 (en) 1998-09-18 2003-06-24 Massachusetts Institute Of Technology Use of fibroblast growth factor 2 for expansion of chondrocytes and tissue engineering
US7141072B2 (en) 1998-10-05 2006-11-28 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damaged joint using multi-layer covering
US6454811B1 (en) 1998-10-12 2002-09-24 Massachusetts Institute Of Technology Composites for tissue regeneration and methods of manufacture thereof
US7070942B2 (en) 1998-10-14 2006-07-04 Depuy Spine, Inc. Method of inducing or enhancing chondrogenesis with extracellular matrix containing GDF-5
US7479160B2 (en) 1998-10-28 2009-01-20 Warsaw Orthopedic, Inc. Interbody fusion grafts and instrumentation
US6486377B2 (en) 1998-11-06 2002-11-26 Aventis Behring Gmbh Flexible wound covering based on fibrin and process for its production
US6310267B1 (en) 1998-11-06 2001-10-30 Aventis Behring Gmbh Flexible wound covering based on fibrin and process for its production
US20010031254A1 (en) 1998-11-13 2001-10-18 Bianchi John R. Assembled implant
US20040115172A1 (en) 1998-11-13 2004-06-17 Regeneration Technologies, Inc. Assembled implant, including mixed-composition segment
US6761887B1 (en) 1998-11-16 2004-07-13 Osiris Therapeutics, Inc. Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells
US6165486A (en) 1998-11-19 2000-12-26 Carnegie Mellon University Biocompatible compositions and methods of using same
US6025538A (en) 1998-11-20 2000-02-15 Musculoskeletal Transplant Foundation Compound bone structure fabricated from allograft tissue
US7044968B1 (en) 1998-11-20 2006-05-16 Musculoskeletal Transplant Foundation Compound bone structure of allograft tissue with threaded fasteners
US6306174B1 (en) 1998-12-18 2001-10-23 Benoist Girard Sas Femoral component
US20010018619A1 (en) 1998-12-22 2001-08-30 Robert-Jan Enzerink Graft material convenience package
US20010021875A1 (en) 1998-12-22 2001-09-13 Robert-Jan Enzerink Graft material convenience package
US20050261767A1 (en) 1999-01-05 2005-11-24 Lifenet Composite bone graft, method of making and using same
US6458158B1 (en) 1999-01-05 2002-10-01 Lifenet Composite bone graft, method of making and using same
US6200347B1 (en) 1999-01-05 2001-03-13 Lifenet Composite bone graft, method of making and using same
US6902578B1 (en) 1999-01-05 2005-06-07 Lifenet Composite bone graft, method of making and using same
US6383221B1 (en) 1999-01-22 2002-05-07 Osteotech, Inc. Method for forming an intervertebral implant
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
US20040192605A1 (en) 1999-02-01 2004-09-30 Genetics Institute, Llc Methods and compositions for healing and repair of articular cartilage
US7323445B2 (en) 1999-02-01 2008-01-29 Genetics Institute, Llc Methods and compositions for healing and repair of articular cartilage
US7563455B2 (en) 1999-02-04 2009-07-21 Warsaw Orthopedic, Inc. Highly-mineralized osteogenic sponge compositions, and uses thereof
US6267786B1 (en) 1999-02-11 2001-07-31 Crosscart, Inc. Proteoglycan-reduced soft tissue xenografts
US6294187B1 (en) 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
US6440444B2 (en) 1999-02-23 2002-08-27 Osteotech, Inc. Load bearing osteoimplant and method of repairing bone using the same
US20010043940A1 (en) 1999-02-23 2001-11-22 Boyce Todd M. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
US6696073B2 (en) 1999-02-23 2004-02-24 Osteotech, Inc. Shaped load-bearing osteoimplant and methods of making same
US6197061B1 (en) 1999-03-01 2001-03-06 Koichi Masuda In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage
US6451060B2 (en) 1999-03-01 2002-09-17 Rush-Presbyterian-St. Luke's Medical Center Cartilage matrix and in vitro production of transplantable cartilage tissue
US6662805B2 (en) 1999-03-24 2003-12-16 The Johns Hopkins University Method for composite cell-based implants
US20010051834A1 (en) 1999-03-24 2001-12-13 Chondros, Inc. Method for composite cell-based implants
US6398972B1 (en) 1999-04-12 2002-06-04 Harvest Technologies Corporation Method for producing platelet rich plasma and/or platelet concentrate
US7297161B2 (en) 1999-05-10 2007-11-20 Fell Barry M Surgically implantable knee prosthesis
US7338524B2 (en) 1999-05-10 2008-03-04 Fell Barry M Surgically implantable knee prosthesis
US6468314B2 (en) 1999-06-04 2002-10-22 Depuy Orthopaedics, Inc. Cartilage repair unit
US6251143B1 (en) 1999-06-04 2001-06-26 Depuy Orthopaedics, Inc. Cartilage repair unit
US20010010023A1 (en) 1999-06-04 2001-07-26 Schwartz Robert E. Cartilage repair unit
US6734018B2 (en) 1999-06-07 2004-05-11 Lifenet Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
US20080077251A1 (en) 1999-06-07 2008-03-27 Chen Silvia S Cleaning and devitalization of cartilage
US7662184B2 (en) 1999-06-08 2010-02-16 Osteotech, Inc. Osteoimplant and method for making same
US20070168030A1 (en) 1999-06-08 2007-07-19 Edwards Jean T Osteoimplant and Method for Making Same
US6288043B1 (en) 1999-06-18 2001-09-11 Orquest, Inc. Injectable hyaluronate-sulfated polysaccharide conjugates
US6534084B1 (en) 1999-06-30 2003-03-18 Ethicon, Inc. Porous tissue scaffoldings for the repair or regeneration of tissue
US6306424B1 (en) 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
US6333029B1 (en) 1999-06-30 2001-12-25 Ethicon, Inc. Porous tissue scaffoldings for the repair of regeneration of tissue
US6652872B2 (en) 1999-07-06 2003-11-25 Ramat At Tel Aviv University Ltd. Scaffold formed of tissue treated to eliminate cellular and cytosolic elements
US20020009805A1 (en) 1999-07-06 2002-01-24 Ramot University Authority For Applied Research & Industrial Development Ltd. Scaffold matrix and tissue maintaining systems
US7078232B2 (en) 1999-08-19 2006-07-18 Artecel, Inc. Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof
US7033587B2 (en) 1999-08-19 2006-04-25 Artecel Sciences, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
US6841150B2 (en) 1999-08-19 2005-01-11 Artecal, Sciences, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
US20050112761A1 (en) 1999-08-19 2005-05-26 Artecel Sciences, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
US20070134291A1 (en) 1999-10-05 2007-06-14 Kang Ting Composition for cartilage
US20040028717A1 (en) 1999-11-24 2004-02-12 Transtissue Technologies, Gmbh Implantable substrates for the healing and protection of connective tissue, preferably cartilage
US20080183300A1 (en) 1999-12-03 2008-07-31 University Of Leeds Fixation technology
EP1719463A1 (en) 1999-12-03 2006-11-08 University Of Leeds Repair of damaged tissue
EP1237511B1 (en) 1999-12-15 2004-09-01 Sulzer Orthopedics Ltd. Preparation for repairing cartilage defects or cartilage/bone defects in human or animal joints
EP1237511A1 (en) 1999-12-15 2002-09-11 Sulzer Orthopedics Ltd. Preparation for repairing cartilage defects or cartilage/bone defects in human or animal joints
US6858042B2 (en) 1999-12-15 2005-02-22 Zimmer Orthobiologics, Inc. Preparation for repairing cartilage defects or cartilage/bone defects in human or animal joints
US6623963B1 (en) 1999-12-20 2003-09-23 Verigen Ag Cellular matrix
US6579538B1 (en) 1999-12-22 2003-06-17 Acell, Inc. Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US6376244B1 (en) 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
US6458144B1 (en) 1999-12-30 2002-10-01 Osteotech, Inc. Methods for manufacturing skeletal implants
US6379385B1 (en) 2000-01-06 2002-04-30 Tutogen Medical Gmbh Implant of bone matter
US6893462B2 (en) 2000-01-11 2005-05-17 Regeneration Technologies, Inc. Soft and calcified tissue implants
US6497726B1 (en) 2000-01-11 2002-12-24 Regeneration Technologies, Inc. Materials and methods for improved bone tendon bone transplantation
US20050101957A1 (en) 2000-01-11 2005-05-12 Regeneration Technologies, Inc. Soft and calcified tissue implants
US7513910B2 (en) 2000-01-11 2009-04-07 Rti Biologics, Inc. Soft and calcified tissue implants
US20020072806A1 (en) 2000-01-11 2002-06-13 Dayna Buskirk Soft and calcified tissue implants
US20020106393A1 (en) 2000-02-10 2002-08-08 Bianchi John R. Assembled implant, including mixed-composition segment
US6371958B1 (en) 2000-03-02 2002-04-16 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US7182781B1 (en) 2000-03-02 2007-02-27 Regeneration Technologies, Inc. Cervical tapered dowel
US6591581B2 (en) 2000-03-08 2003-07-15 Arthrex, Inc. Method for preparing and inserting round, size specific osteochondral cores in the knee
US20040039447A1 (en) 2000-03-14 2004-02-26 Ultra Tec Manufacturing, Inc. Cartilage repair plug
US6852125B2 (en) 2000-03-14 2005-02-08 Chondrosite, Inc. Cartilage repair plug
US20010039457A1 (en) 2000-03-22 2001-11-08 Boyer Michael L. Plugs for filling bony defects
US20010039458A1 (en) 2000-03-22 2001-11-08 Boyer Michael L. Implants formed of coupled bone
US6632247B2 (en) 2000-03-22 2003-10-14 Synthes (Usa) Implants formed of coupled bone
US20010041941A1 (en) 2000-03-22 2001-11-15 Boyer Michael L. Multipiece implants formed of bone material
US20060276907A1 (en) 2000-03-22 2006-12-07 Boyer Michael L Ii Multipiece implants formed of bone material
US6767369B2 (en) 2000-03-22 2004-07-27 Synthes (Usa) Plugs for filling bony defects
US20040138748A1 (en) 2000-03-22 2004-07-15 Synthes (Usa) Plugs for filling bony defects
US7115146B2 (en) 2000-03-22 2006-10-03 Boyer Ii Michael L Multipiece implants formed of bone material
US6689747B2 (en) 2000-03-24 2004-02-10 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
US6933328B2 (en) 2000-04-03 2005-08-23 Universiteit Gent Composition of crosslinkable prepolymers for biodegradable implants
US6932977B2 (en) 2000-04-14 2005-08-23 Depuy Spine, Inc. Method of inducing or enhancing chondrogenesis with extracellular matrix containing BMP-4
US20020055783A1 (en) 2000-05-01 2002-05-09 Tallarida Steven J. System and method for joint resurface repair
US6520964B2 (en) 2000-05-01 2003-02-18 Std Manufacturing, Inc. System and method for joint resurface repair
US7108721B2 (en) 2000-05-11 2006-09-19 Massachusetts Institute Of Technology Tissue regrafting
US7179299B2 (en) 2000-05-12 2007-02-20 Osteotech, Inc. Osteoimplant and method for making same
US20030144743A1 (en) 2000-05-12 2003-07-31 Edwards Jean T. Osteoimplant and method for making same
US20020082704A1 (en) 2000-05-15 2002-06-27 Cryolife, Inc. Osteochondral transplant techniques
US6852114B2 (en) 2000-05-15 2005-02-08 Cryolife, Inc. Osteochondral transplant techniques
US6488033B1 (en) 2000-05-15 2002-12-03 Cryolife, Inc. Osteochondral transplant techniques
US6686184B1 (en) 2000-05-25 2004-02-03 President And Fellows Of Harvard College Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks
US6808585B2 (en) 2000-07-03 2004-10-26 Osteotech, Inc. Osteogenic implants derived from bone
US20020035401A1 (en) 2000-07-03 2002-03-21 Osteotech, Inc. Osteogenic implants derived from bone
US20060200166A1 (en) 2000-07-06 2006-09-07 Zimmer Spine, Inc. Bone implants and methods
US7018416B2 (en) 2000-07-06 2006-03-28 Zimmer Spine, Inc. Bone implants and methods
US20060030948A1 (en) 2000-07-19 2006-02-09 Albert Manrique Osteoimplant and method of making same
US6576015B2 (en) 2000-07-19 2003-06-10 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Bone material and collagen combination for repair of injured joints
US6815416B2 (en) 2000-07-20 2004-11-09 The Board Of Regents, The University Of Texas System Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor
US20020042373A1 (en) 2000-07-20 2002-04-11 The Board Of Regents, The University Of Texas System Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor
US6440141B1 (en) 2000-07-24 2002-08-27 Oratec Interventions, Inc. Method and apparatus for treating osteochondral pathologies
US20040033212A1 (en) 2000-07-29 2004-02-19 Thomson Brian Mark Tissue implant
US20030023316A1 (en) 2000-08-04 2003-01-30 Brown Laura Jean Hybrid biologic-synthetic bioabsorable scaffolds
US6730314B2 (en) 2000-08-29 2004-05-04 Merck Patent Gesellschaft Culturing encapsulated chondrocytes under reduced oxygen partial pressure to produce cartilage implants
US6432436B1 (en) 2000-10-03 2002-08-13 Musculoskeletal Transplant Foundation Partially demineralized cortical bone constructs
US20090248592A1 (en) 2000-10-20 2009-10-01 Reinhold Schmieding Method of selling procedure specific allografts and associated instrumentation
US7548865B2 (en) 2000-10-20 2009-06-16 Arthrex, Inc. Method of selling procedure specific allografts and associated instrumentation
US7288406B2 (en) 2000-10-31 2007-10-30 Prochon Biotech Ltd. Active variants of FGF with improved specificity
US6884428B2 (en) 2000-12-21 2005-04-26 Depuy Mitek, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US7371400B2 (en) 2001-01-02 2008-05-13 The General Hospital Corporation Multilayer device for tissue engineering
US6838440B2 (en) 2001-01-24 2005-01-04 Collagen Nutraceuticals, Inc. Kolla2-desiccated avian sternal cartilage powder
US20080038314A1 (en) 2001-01-30 2008-02-14 Hunziker Ernst B Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial-derived tissue or cells
US20080039955A1 (en) 2001-01-30 2008-02-14 Hunziker Ernst B Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial-derived tissue or cells
US20040243242A1 (en) 2001-02-14 2004-12-02 Sybert Daryl R. Implant derived from bone
US20070055377A1 (en) 2001-02-16 2007-03-08 Zimmer Spine, Inc. Bone implants and methods
US20030050709A1 (en) 2001-02-23 2003-03-13 Ulrich Noth Trabecular bone-derived human mesenchymal stem cells
EP1234552A1 (en) 2001-02-26 2002-08-28 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
EP1234555B1 (en) 2001-02-26 2007-02-07 Ethicon, Inc. Tissue scaffold anchor for cartilage repair
US6743232B2 (en) 2001-02-26 2004-06-01 David W. Overaker Tissue scaffold anchor for cartilage repair
US20020120274A1 (en) 2001-02-26 2002-08-29 Ethicon, Inc. Tissue scaffold anchor for cartilage repair
EP1234555A3 (en) 2001-02-26 2004-06-16 Ethicon, Inc. Tissue scaffold anchor for cartilage repair
EP1234555A2 (en) 2001-02-26 2002-08-28 Ethicon, Inc. Tissue scaffold anchor for cartilage repair
EP1234552B1 (en) 2001-02-26 2006-08-16 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US6776800B2 (en) 2001-02-28 2004-08-17 Synthes (U.S.A.) Implants formed with demineralized bone
US6652593B2 (en) 2001-02-28 2003-11-25 Synthes (Usa) Demineralized bone implants
US6855169B2 (en) 2001-02-28 2005-02-15 Synthes (Usa) Demineralized bone-derived implants
US20040107003A1 (en) 2001-02-28 2004-06-03 Synthes (Usa) Demineralized bone implants
US7608113B2 (en) 2001-02-28 2009-10-27 Synthes Usa, Llc Demineralized bone implants
US20040170610A1 (en) 2001-03-05 2004-09-02 Shimon Slavin Compositions comprising bone marrow cells together with demineralized and/or mineralized bone matrix and uses thereof in the induction of bone and cartilage formation
US20020177224A1 (en) 2001-03-15 2002-11-28 Henning Madry Tissue engineering enhanced by the transfer of a growth factor gene
US6949252B2 (en) 2001-03-23 2005-09-27 Histogenics, Corp. Method for preparing an implantable multilayer tissue construct
US20030040113A1 (en) 2001-03-23 2003-02-27 Histogenics Corporation Composition and methods for the production of biological tissues and tissue constructs
US20090312805A1 (en) 2001-05-25 2009-12-17 Conformis, Inc. Methods and compositions for articular repair
US20030055502A1 (en) 2001-05-25 2003-03-20 Philipp Lang Methods and compositions for articular resurfacing
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
US20070083266A1 (en) 2001-05-25 2007-04-12 Vertegen, Inc. Devices and methods for treating facet joints, uncovertebral joints, costovertebral joints and other joints
US6626950B2 (en) 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
US7361195B2 (en) 2001-07-16 2008-04-22 Depuy Products, Inc. Cartilage repair apparatus and method
US20040143344A1 (en) 2001-07-16 2004-07-22 Prasanna Malaviya Implantable tissue repair device and method
US20050027307A1 (en) 2001-07-16 2005-02-03 Schwartz Herbert Eugene Unitary surgical device and method
US20030021827A1 (en) 2001-07-16 2003-01-30 Prasanna Malaviya Hybrid biologic/synthetic porous extracellular matrix scaffolds
WO2003007879A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Cartilage repair and regeneration scaffold and method
US7201917B2 (en) 2001-07-16 2007-04-10 Depuy Products, Inc. Porous delivery scaffold and method
EP1416880B1 (en) 2001-07-16 2011-03-02 DePuy Products, Inc. Cartilage repair apparatus
WO2003007805A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Cartilage repair apparatus and method
US7163563B2 (en) 2001-07-16 2007-01-16 Depuy Products, Inc. Unitary surgical device and method
US20030078617A1 (en) 2001-07-16 2003-04-24 Schwartz Herbert E. Unitary surgical device and method
US20080167716A1 (en) 2001-07-16 2008-07-10 Schwartz Hebert E Cartilage repair apparatus and method
US20030049299A1 (en) 2001-07-16 2003-03-13 Prasanna Malaviya Porous delivery scaffold and method
US20030036797A1 (en) 2001-07-16 2003-02-20 Prasanna Malaviya Meniscus regeneration device and method
US20030044444A1 (en) 2001-07-16 2003-03-06 Prasanna Malaviya Porous extracellular matrix scaffold and method
US20040220574A1 (en) 2001-07-16 2004-11-04 Pelo Mark Joseph Device from naturally occuring biologically derived materials
US20030033021A1 (en) 2001-07-16 2003-02-13 Plouhar Pamela Lynn Cartilage repair and regeneration scaffold and method
US20030036801A1 (en) 2001-07-16 2003-02-20 Schwartz Herbert E. Cartilage repair apparatus and method
US20030032961A1 (en) 2001-07-16 2003-02-13 Pelo Mark Joseph Devices from naturally occurring biologically derived materials
US20030033022A1 (en) 2001-07-16 2003-02-13 Plouhar Pamela Lynn Cartilage repair and regeneration device and method
WO2003007805A3 (en) 2001-07-16 2004-02-12 Depuy Products Inc Cartilage repair apparatus and method
US7009039B2 (en) 2001-07-19 2006-03-07 Prochon Biotech Ltd. Plasma protein matrices and methods for their preparation
US20030039695A1 (en) 2001-08-10 2003-02-27 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Collagen carrier of therapeutic genetic material, and method
US20070036834A1 (en) 2001-08-29 2007-02-15 Pauletti Giovanni M Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome P450 enzymes and membrane efflux systems following vaginal and oral cavity administration
US7132110B2 (en) 2001-08-30 2006-11-07 Isotis Orthobiologics, Inc. Tissue repair compositions and methods for their manufacture and use
US7476257B2 (en) 2001-09-15 2009-01-13 Rush University Medical Center Methods to engineer stratified cartilage tissue
US6855167B2 (en) 2001-12-05 2005-02-15 Osteotech, Inc. Spinal intervertebral implant, interconnections for such implant and processes for making
US7252987B2 (en) 2001-12-06 2007-08-07 Islet Technology, Inc. System for analysis and selection of encapsulated cellular materials
US20050020500A1 (en) 2002-01-23 2005-01-27 Bojang Shen Nutraceuticals for the treatment, protection and restoration of connective tissues
US6852331B2 (en) 2002-02-11 2005-02-08 Taipei Biotechnology Ltd., Inc. Fabrication of a cartilage implant
US6890354B2 (en) 2002-03-08 2005-05-10 Musculoskeletal Transplant Foundation Bone-tendon-bone assembly with allograft bone block and method for inserting same
US20040151705A1 (en) 2002-03-22 2004-08-05 Shuichi Mizuno Neo-cartilage constructs and a method for preparation thereof
US20060216822A1 (en) 2002-03-22 2006-09-28 Histogenics Corporation Method for preparation of neo-cartilage constructs
US20040134502A1 (en) 2002-03-22 2004-07-15 Shuichi Mizuno Method for in situ repair of injured, damaged, diseased or aged articular cartilage
US7537780B2 (en) 2002-03-22 2009-05-26 Histogenics Corporation Method for preparing and implanting a cartilage construct to treat cartilage lesions
US7468192B2 (en) 2002-03-22 2008-12-23 Histogenics Corporation Method for repair of cartilage lesions
US7563769B2 (en) 2002-05-09 2009-07-21 ProChon Biotech, Ltd. FGF variants and methods for use thereof
US20030229400A1 (en) 2002-05-13 2003-12-11 Koichi Masuda Tissue engineered osteochondral implant
US20050159820A1 (en) 2002-05-13 2005-07-21 Hideki Yoshikawa Member for regenerating joint cartilage and process for producing the same, method of regenerating joint cartilage and artificial cartilage for transplantation
US7338492B2 (en) 2002-05-15 2008-03-04 Linvatec Corporation Cross-pin graft fixation, instruments, and methods
US6989034B2 (en) 2002-05-31 2006-01-24 Ethicon, Inc. Attachment of absorbable tissue scaffolds to fixation devices
US7156880B2 (en) 2002-06-13 2007-01-02 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US20080015709A1 (en) 2002-06-13 2008-01-17 Evans Douglas G Devices and methods for treating defects in the tissue of a living being
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US20030236573A1 (en) 2002-06-13 2003-12-25 Evans Douglas G. Devices and methods for treating defects in the tissue of a living being
US7241316B2 (en) 2002-06-13 2007-07-10 Douglas G Evans Devices and methods for treating defects in the tissue of a living being
US20040127987A1 (en) 2002-06-13 2004-07-01 Evans Douglas G. Devices and methods for treating defects in the tissue of a living being
US7658768B2 (en) 2002-06-24 2010-02-09 Wright Medical Technology, Inc. Bone graft substitute composition
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US6995013B2 (en) 2002-07-08 2006-02-07 Biomed Solutions, Llc Cell-scaffold composition containing five layers
US20040166169A1 (en) 2002-07-15 2004-08-26 Prasanna Malaviya Porous extracellular matrix scaffold and method
US20040197311A1 (en) 2002-07-19 2004-10-07 Brekke John H. Device for regeneration of articular cartilage and other tissue
US20070299519A1 (en) 2002-09-20 2007-12-27 Reinhold Schmieding Preformed implants for osteochondral repair
US7264634B2 (en) 2002-09-20 2007-09-04 Arthrex, Inc. Method and instrumentation for osteochondral repair using preformed implants
US20040062753A1 (en) 2002-09-27 2004-04-01 Alireza Rezania Composite scaffolds seeded with mammalian cells
US7323011B2 (en) 2002-10-18 2008-01-29 Musculoskeletal Transplant Foundation Cortical and cancellous allograft cervical fusion block
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US7824701B2 (en) 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US6761739B2 (en) 2002-11-25 2004-07-13 Musculoskeletal Transplant Foundation Cortical and cancellous allograft spacer
US20040102850A1 (en) 2002-11-25 2004-05-27 Shepard Yolanda Denise Cortical and cancellous allograft spacer
US20060099234A1 (en) 2002-12-05 2006-05-11 Heinz Winkler Implant containing cultured cartilage cells and method for producing this implant
WO2004067704A2 (en) 2003-01-30 2004-08-12 Prochon Biotech Ltd. Freeze-dried fibrin matrices and methods for preparation thereof
US20060216323A1 (en) 2003-02-04 2006-09-28 David Knaack Polyurethanes for osteoimplants
WO2004069298A1 (en) 2003-02-06 2004-08-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Fgf-2 derived proteins for the preparation of biomaterials or medical devices such as stents
US20070148242A1 (en) 2003-02-26 2007-06-28 Zimmer Orthobiologics, Inc Preparation for repairing cartilage tissue, especially articular cartilage defects
WO2004075940A1 (en) 2003-02-26 2004-09-10 Zimmer Orthobiologics, Inc. Preparation for repairing cartilage tissue, especially articular cartilage defects
US20040175826A1 (en) 2003-03-03 2004-09-09 Technion Research & Development Foundation Ltd. Cultured cartilage/bone cells/tissue, method of generating same and uses thereof
US7642092B2 (en) 2003-03-03 2010-01-05 Technion Research & Development Foundation Ltd. Cultured cartilage/bone cells/tissue, method of generating same and uses thereof
US7125423B2 (en) 2003-03-31 2006-10-24 Depuy Products, Inc. Intercalary prosthesis, kit and method
US20040193268A1 (en) 2003-03-31 2004-09-30 Hazebrouck Stephen A. Intercalary prosthesis, kit and method
US20080274157A1 (en) 2003-04-29 2008-11-06 Gordana Vunjak-Novakovic Cartilage implant plug with fibrin glue and method for implantation
WO2005110278A2 (en) 2003-04-29 2005-11-24 Musculoskeletal Transplant Foundation Cartilage repair mixture containing allograft chondrocytes
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
EP1740121A2 (en) 2003-04-29 2007-01-10 Musculoskeletal Transplant Foundation Cartilage repair mixture containing allograft chondrocytes
US20080133008A1 (en) 2003-04-29 2008-06-05 Muscuoskeletal Transplant Foundation Cartilage repair mixture containing allograft chondrocytes
EP1618178B1 (en) 2003-04-29 2008-07-16 Musculoskeletal Transplant Foundation Novel glue for cartilage repair
US20050064042A1 (en) 2003-04-29 2005-03-24 Musculoskeletal Transplant Foundation Cartilage implant plug with fibrin glue and method for implantation
WO2005110278A3 (en) 2003-04-29 2006-08-10 Musculoskeletal Transplant Cartilage repair mixture containing allograft chondrocytes
US20040219182A1 (en) 2003-04-29 2004-11-04 Gomes Katherine A. Novel glue for cartilage repair
WO2004096983A3 (en) 2003-04-29 2005-12-22 Musculoskeletal Transplant Novel glue for cartilage repair
US20060210643A1 (en) 2003-04-29 2006-09-21 Truncale Katherine A G Cartilage repair mixture containing allograft chondrocytes
WO2004096983A2 (en) 2003-04-29 2004-11-11 Musculoskeletal Transplant Foundation Novel glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20040230303A1 (en) 2003-05-16 2004-11-18 Gomes Katherine A. Cartilage allograft plug
US20050251268A1 (en) 2003-05-16 2005-11-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
WO2004103224A1 (en) 2003-05-16 2004-12-02 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20090291112A1 (en) 2003-05-16 2009-11-26 Truncale Katherine G Allograft osteochondral plug combined with cartilage particle mixture
US7488348B2 (en) 2003-05-16 2009-02-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20090069901A1 (en) 2003-05-16 2009-03-12 Katherine Gomes Truncale Cartilage allograft plug
US7537617B2 (en) 2003-06-05 2009-05-26 Warsaw Orthopedic, Inc. Bone strip implants and method of making same
US20070067032A1 (en) 2003-06-27 2007-03-22 Felt Jeffrey C Meniscus preserving implant method and apparatus
US20080039939A1 (en) 2003-07-31 2008-02-14 Yukihide Iwamoto Method of Constructing Artificial Joint
US20090117652A1 (en) 2003-08-12 2009-05-07 Tigenix N.V. Use of cxcl6 chemokine in the prevention or repair of cartilage defects
US7485310B2 (en) 2003-08-12 2009-02-03 Tigenix N.V. Use of CXCL6 chemokine in the prevention or repair of cartilage defects
US20070014867A1 (en) 2003-08-20 2007-01-18 Histogenics Corp Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and a method for use thereof
US7217294B2 (en) 2003-08-20 2007-05-15 Histogenics Corp. Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof
US20050043814A1 (en) 2003-08-20 2005-02-24 Akihiko Kusanagi Acellular matrix implanted into an articular cartilage or osteochondral lesion protected with a biodegradable polymer modified to have extended polymerization time and methods for preparation and use thereof
US7601173B2 (en) 2003-09-02 2009-10-13 Synthes Usa, Llc Multipiece allograft implant
US7226482B2 (en) 2003-09-02 2007-06-05 Synthes (U.S.A.) Multipiece allograft implant
US7628851B2 (en) 2003-09-05 2009-12-08 Synthes Usa, Llc Bone cement compositions having fiber-reinforcement and/or increased flowability
US20050260612A1 (en) 2003-10-02 2005-11-24 Depuy Spine, Inc. Chemical treatment for removing cellular and nuclear material from naturally occurring extracellular matrix-based biomaterials
US20050074476A1 (en) 2003-10-03 2005-04-07 El Gendler Cartilidge and bone induction by artificially perforated organic bone matrix augmented by undifferentiated cells suspended in bone gel
US7632311B2 (en) 2003-10-28 2009-12-15 Xiros Plc Repair of damaged tissue on a bone site
US20050228498A1 (en) 2003-11-18 2005-10-13 Todd Andres Osteoconductive integrated spinal cage and method of making same
US7157428B2 (en) 2003-11-26 2007-01-02 Histogenics, Corp. Method for treatment and repair of meniscal injuries
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7875296B2 (en) 2003-11-26 2011-01-25 Depuy Mitek, Inc. Conformable tissue repair implant capable of injection delivery
US7901461B2 (en) 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
EP1537883B1 (en) 2003-12-05 2008-04-23 DePuy Mitek, Inc. Implants comprising viable tissue for repairing a tissue injury or defect
US20050125077A1 (en) 2003-12-05 2005-06-09 Harmon Alexander M. Viable tissue repair implants and methods of use
US7666230B2 (en) 2003-12-08 2010-02-23 Depuy Products, Inc. Implant device for cartilage regeneration in load bearing articulation regions
WO2005058207A1 (en) 2003-12-11 2005-06-30 Isto Technologies, Inc. Particulate cartilage system
US20050152882A1 (en) 2003-12-11 2005-07-14 Isto Technologies Particulate cartilage system
US20060178748A1 (en) 2004-02-05 2006-08-10 Dinger Fred B Iii Implants and delivery system for treating defects in articulating surfaces
EP1561481A2 (en) 2004-02-09 2005-08-10 DePuy Mitek, Inc. Scaffolds with viable tissue
US20050196460A1 (en) 2004-03-08 2005-09-08 Malinin Theodore I. Particulate cartilage compositions, processes for their preparation and methods for regenerating cartilage
US20070098759A1 (en) 2004-03-08 2007-05-03 Malinin Theodore I Method for regenerating cartilage
US20110052705A1 (en) 2004-03-08 2011-03-03 Malinin Theodore I Cartilage composition and process for producing the cartilage composition
US20070185585A1 (en) 2004-03-09 2007-08-09 Brat Bracy Implant Scaffold Combined With Autologous Tissue, Allogenic Tissue, Cultured Tissue, or combinations Thereof
US20050209705A1 (en) 2004-03-09 2005-09-22 Niederauer Gabriele G Implant scaffold combined with autologous or allogenic tissue
WO2007024238A1 (en) 2004-04-02 2007-03-01 Musculoskeletal Transplant Foundation Cartilage implant assembly and method for implantation
US20090043389A1 (en) 2004-04-02 2009-02-12 Gordana Vunjak-Novakovic Cartilage implant plug with fibrin glue and method for implantation
US20050222687A1 (en) 2004-04-02 2005-10-06 Gordana Vunjak-Novakovic Cartilage implant assembly and method for implantation
US7648700B2 (en) 2004-05-14 2010-01-19 Unigene Laboratories, Inc. Method for fostering bone formation and preservation
US7648965B2 (en) 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US20080031915A1 (en) 2004-05-21 2008-02-07 Jose Becerra Ratia Cartilage and Bone Repair Composition
US20050288796A1 (en) 2004-06-23 2005-12-29 Hani Awad Native soft tissue matrix for therapeutic applications
US7335508B2 (en) 2004-07-22 2008-02-26 Prochon Biotech Ltd. Porous plasma protein matrices and methods for preparation thereof
US20090324722A1 (en) 2004-09-22 2009-12-31 Elisseeff Jennifer H Cartilage filling device
WO2006036681A2 (en) 2004-09-22 2006-04-06 Cartilix, Inc. Cartilage filling device
US20060060209A1 (en) 2004-09-23 2006-03-23 Shepard David O Osteochondral repair using plug fashioned from partial distal allograft femur or condyle
US7273756B2 (en) 2004-10-01 2007-09-25 Isto Technologies, Inc. Method for chondrocyte expansion with phenotype retention
WO2006042311A3 (en) 2004-10-12 2006-11-23 Musculoskeletal Transplant Cartilage implant plug with fibrin glue and method for implantation
WO2006042311A2 (en) 2004-10-12 2006-04-20 Musculoskeletal Transplant Foundation Cartilage implant plug with fibrin glue and method for implantation
US20090319045A1 (en) 2004-10-12 2009-12-24 Truncale Katherine G Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US20060111778A1 (en) 2004-10-29 2006-05-25 Michalow Alexander E Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway
WO2006050213A2 (en) 2004-10-29 2006-05-11 Michalow Alexander E Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway
US20080125868A1 (en) 2004-12-13 2008-05-29 Rickard Branemark Implant And An Implant Member
US20070041950A1 (en) 2005-02-01 2007-02-22 Osteobiologics, Inc. Method and device for selective addition of a bioactive agent to a multi-phase implant
US7621963B2 (en) 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
US20080051889A1 (en) 2005-04-15 2008-02-28 Zimmer, Inc. Cartilage implant
WO2006113586A3 (en) 2005-04-15 2007-09-20 Musculoskeletal Transplant Vertebral disc repair
WO2006113586A2 (en) 2005-04-15 2006-10-26 Musculoskeletal Transplant Foundation Vertebral disc repair
US20060235534A1 (en) 2005-04-15 2006-10-19 Gertzman Arthur A Vertebral disc repair
US7531000B2 (en) 2005-04-15 2009-05-12 Zimmer, Inc. Cartilage implant
US7291169B2 (en) 2005-04-15 2007-11-06 Zimmer Technology, Inc. Cartilage implant
US20060247791A1 (en) 2005-04-29 2006-11-02 Mckay William F Multi-purpose medical implant devices
US20060247790A1 (en) 2005-04-30 2006-11-02 Mckay William F Shaped osteochondral grafts and methods of using same
US20060251631A1 (en) 2005-05-05 2006-11-09 Isto Technologies, Inc. Treatment of joint disease, methods and apparatuses therefor
US20060293757A1 (en) 2005-06-22 2006-12-28 Mckay William F Osteograft treatment to promote osteoinduction and osteograft incorporation
US20070009610A1 (en) 2005-07-11 2007-01-11 Carina Syring Engineered osteochondral construct for treatment of articular cartilage defects
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US7622438B1 (en) 2005-07-18 2009-11-24 Acologix, Inc. Protein formulation for promoting hard tissue formation
US7638486B2 (en) 2005-07-18 2009-12-29 Acologix, Inc. Method for promoting hard tissue formation
US20070026030A1 (en) 2005-07-27 2007-02-01 Berkeley Advanced Biomaterials, Inc. Method of preparing rheological materials for bone and cartilage repair
US20070065943A1 (en) 2005-09-19 2007-03-22 Histogenics Corp. Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US20070093912A1 (en) 2005-10-25 2007-04-26 Mark Borden Porous and nonporous materials for tissue grafting and repair
US20070135917A1 (en) 2005-10-26 2007-06-14 Malinin Theodore I Instrumentation for the preparation and transplantation of osteochondral allografts
US20070135918A1 (en) 2005-10-26 2007-06-14 Malinin Theodore I Instrumentation for the preparation and transplantation of osteochondral allografts
US20070135928A1 (en) 2005-10-26 2007-06-14 Malinin Theodore I Osteochondral allografts
US20070093896A1 (en) 2005-10-26 2007-04-26 Malinin Theodore I Method and instrumentation for the preparation and transplantation of osteochondral allografts
US7550007B2 (en) 2005-10-26 2009-06-23 Biomet Sports Medicine, Llc Osteochondral allografts
US20070100450A1 (en) 2005-11-02 2007-05-03 Zimmer Technology, Inc. Joint spacer implant
US20070113951A1 (en) 2005-11-07 2007-05-24 National Tsing Hua University Osteochondral composite scaffold for articular cartilage repair and preparation thereof
US20070128155A1 (en) 2005-12-07 2007-06-07 Isto Technologies, Inc. Cartilage repair methods
US20090319051A9 (en) 2005-12-07 2009-12-24 Nycz Jeffrey H Osteochondral plug graft, kit and method
US20090210057A1 (en) 2005-12-29 2009-08-20 Chun-Jan Liao Multi-layered implant prepared by a method of tissue repair using a multi-layered matrix
US20070162121A1 (en) 2006-01-12 2007-07-12 Tarrant Laurence J Method for repair and reconstruction of ruptured ligaments or tendons and for treatment of ligament and tendon injuries
US20070172506A1 (en) 2006-01-25 2007-07-26 Sdgi Holdings, Inc. Osteochondral implant procedure
US20070179607A1 (en) 2006-01-31 2007-08-02 Zimmer Technology, Inc. Cartilage resurfacing implant
US20090280179A1 (en) 2006-02-09 2009-11-12 Hans-Georg Neumann Resorbable Calcium Phosphate Based Biopolymer-Cross-Linked Bone Replacement Material
US7416889B2 (en) 2006-04-27 2008-08-26 Rhode Island Hospital Methods and compositions for repairing cartilage
US20070276506A1 (en) 2006-05-25 2007-11-29 Biomet Manufacturing Corp. Demineralized osteochondral plug
US20070299517A1 (en) 2006-06-21 2007-12-27 Howmedica Osteonics Corp. Articular cartilage implant
US20100241228A1 (en) 2006-07-07 2010-09-23 Carina Syring Engineered osteochondral construct for treatment of articular cartilage defects
US20080027546A1 (en) 2006-07-25 2008-01-31 Semler Eric J Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
WO2008013763A3 (en) 2006-07-25 2008-06-26 Morris L Jacobs Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
WO2008013763A2 (en) 2006-07-25 2008-01-31 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
WO2008021127A2 (en) 2006-08-08 2008-02-21 Howmedica Osteonics Corp. Expandable cartilage implant
US20080039954A1 (en) 2006-08-08 2008-02-14 Howmedica Osteonics Corp. Expandable cartilage implant
US20080058953A1 (en) 2006-08-31 2008-03-06 Scarborough Nelson L Demineralized cancellous strip DBM graft
US20080065210A1 (en) 2006-09-11 2008-03-13 Mckay William F Multi-phase osteochondral implantable device
WO2008038287A2 (en) 2006-09-28 2008-04-03 Hepacore Ltd. N-terminal fgf variants having increased receptor selectivity and uses thereof
WO2008038287A3 (en) 2006-09-28 2009-04-23 Hepacore Ltd N-terminal fgf variants having increased receptor selectivity and uses thereof
US20080119947A1 (en) 2006-11-18 2008-05-22 Smith & Nephew, Inc. Annular Ring Implant
US20080125863A1 (en) 2006-11-28 2008-05-29 Mckay William F Implant designs and methods of improving cartilage repair
US20080138414A1 (en) 2006-12-08 2008-06-12 Smith & Nephew, Inc. Methods of Regenerating Cartilage
US20080153157A1 (en) 2006-12-20 2008-06-26 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US20080154372A1 (en) 2006-12-21 2008-06-26 Peckham Steven M Osteochondral implant using a growth factor concentration gradient for repair of bone and cartilage tissue
WO2008081463A2 (en) 2007-01-04 2008-07-10 Hepacore Ltd. Water soluble reactive derivatives of carboxy polysaccharides and fibrinogen conjugates thereof
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20080255676A1 (en) 2007-01-24 2008-10-16 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
WO2008106254A2 (en) 2007-01-24 2008-09-04 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20080249632A1 (en) 2007-02-26 2008-10-09 Biomet Sports Medicine, Inc. Stable cartilage defect repair plug
US20100015202A1 (en) 2007-03-06 2010-01-21 Semler Eric J Cancellous construct with support ring for repair of osteochondral defects
US20080220044A1 (en) 2007-03-06 2008-09-11 Semler Eric J Cancellous construct with support ring for repair of osteochondral defects
US20110104242A1 (en) 2007-05-10 2011-05-05 Malinin Theodore I Cartilage material
US20080294270A1 (en) 2007-05-24 2008-11-27 Zimmer Orthobiologics, Inc. Differentially processed tissue and processing methods thereof
US20080305145A1 (en) 2007-06-01 2008-12-11 Bacterin International, Inc. Process for demineralization of bone matrix with preservation of natural growth factors
US20090024224A1 (en) 2007-07-16 2009-01-22 Chen Silvia S Implantation of cartilage
US20090081276A1 (en) 2007-08-13 2009-03-26 Eben Alsberg Bioresorbable implant composition
US20090099661A1 (en) 2007-08-14 2009-04-16 Jinia Bhattacharya Multiple component osteoimplant
US20090069904A1 (en) 2007-09-12 2009-03-12 Applied Medical Research Biomaterial including micropores
US20090076624A1 (en) 2007-09-14 2009-03-19 Mohamed Naushad Rahaman Synthetic osteochondral composite and method of fabrication thereof
US20090226523A1 (en) 2007-10-19 2009-09-10 Keyvan Behnam Demineralized bone matrix compositions and methods
US20090131986A1 (en) 2007-11-19 2009-05-21 David Lee Method and apparatus for spinal facet joint fusion using irregularly shaped cortical bone implants
WO2009076164A2 (en) 2007-12-05 2009-06-18 Musculoskeletal Transplant Foundation Cancellous bone implant for cartilage repair
US20090149893A1 (en) 2007-12-05 2009-06-11 Semler Eric J Cancellous Bone Implant for Cartilage Repair
WO2009111069A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US20090299475A1 (en) 2008-06-03 2009-12-03 Gc Corporation Bone graft substitute
US20090312842A1 (en) 2008-06-16 2009-12-17 Predrag Bursac Assembled Cartilage Repair Graft
WO2009155232A1 (en) 2008-06-16 2009-12-23 Rti Biologics, Inc. Assembled cartilage repair graft
US20100036492A1 (en) 2008-07-06 2010-02-11 The Curators Of The University Of Missouri Osteochondral implants, arthroplasty methods, devices, and systems
US20100021521A1 (en) 2008-07-22 2010-01-28 Guo-Feng Xu Prosthesis for joint cartilage repair and method of manufacture
US20100036503A1 (en) 2008-08-07 2010-02-11 Chen Silvia S Composition for a Tissue Repair Implant and Methods of Making the Same
WO2010083051A2 (en) 2009-01-15 2010-07-22 ProChon Biotech, Ltd. Cartilage particle tissue mixtures optionally combined with a cancellous construct
US20100274362A1 (en) 2009-01-15 2010-10-28 Avner Yayon Cartilage particle tissue mixtures optionally combined with a cancellous construct

Non-Patent Citations (213)

* Cited by examiner, † Cited by third party
Title
"Young's Modulus." Entry on http://en.wikipedia.org. accessed Oct. 27, 2005. 3 pages.
(No Author) "Lyophilization" TechnoBusiness-Solutions. (No publication date). Retrieved Jul. 1, 2009 from URL: ,http://www.technobusiness-solutions.com/article-lyophilization1.html> 10 pages. *
A Communication mailed Oct. 9, 2007 in connection with U.S. Appl. No. 10/438,883.
A final Office Action mailed Dec. 28, 2009 in connection with U.S. Appl. No. 11/657,042.
A final Office Action mailed Mar. 15, 2010 in connection with U.S. Appl. No. 10/815,778.
A final Office Action mailed Nov. 13, 2008 in connection with U.S. Appl. No. 10/815,778.
A final Office Action mailed Oct. 18, 2005 in connection with U.S. Appl. No. 10/438,883.
A final Office Action mailed Sep. 19, 2008 in connection with U.S. Appl. No. 11/081,103.
A final Office Action mailed Sep. 28, 2007 in connection with U.S. Appl. No. 10/960,960.
Abraham, Judith A. et al., (1986) Human Basic Fibroblast Growth Factor: Nucleotide Sequence And Genomic Organization. EMBO Journal 5(10):2523-2528.
Advisory Action mailed Dec. 27, 2007 in connection with U.S. Appl. No. 11/151,270.
Agrawal, Sudhir et al., (1991) Pharmacokinetics. Biodistribution, And Stability Of Oligodeoxynucleotide Phosphorothioates In Mice. Proc Natl Acad Sci. USA 88(17):7595-7599.
Andrés et al., "A Pro-Inflammatory Signature Mediates FGF2-induced Angiogenesis", Journal of Cellular and Molecular Medicine, (Jun. 28, 2008), available at http://www.ncbi.nlm.nih.gov/pubmed/18624773.
Arakawa, Tsutomu et al., (1993) Production and Characterization of an Analog of Acidic Fibroblast Growth Factor With Enhanced Stability and Biological Activity. Protein Engineering 6(5):541-546.
Aston et al., "Repair of Articular Surfaces by Allografts of Articular and Growth-Plate Cartilage," Journal of Bone and Joint Surgery, Jan. 1986, vol. 68-B, No. 1; pp. 29-35.
Atala et al. (1993) Injectable alginate seeded with chondrocytes as a potential treatment for vesicoureteral reflux. J. of Urology 150(2 Pt 2):745-7.
Aviles et al., "Testing clinical therapeutic angiogenesis using basic fibroblast growth factor (FGF-2)", British Journal of Pharmacology (2003) 140: 637-646.
Bailly, Karine et al., (2000) Uncoupling of cell proliferation and differentiation activities of basic fibroblast growth factor. FASEB Journal 14(2):333-343.
Baird, "Fibroblast growth factors: activities and significance of non-neurotrophin neurotrophic growth factors", Current Opinions in Neurobiology, (1994) 4:78-86.
Bange, Johannes et al., (2002) Cancer progression and tumor cell motility are associated with the FGFR4 Arg388 allele. Cancer Research 62(3):840-846.
Bork, Peer (2000) Powers and pitfalls in sequence analysis: The 70% hurdle. Genome Res. 10(4):398-400.
Bork, Peer and Bairoch, Amnon (1996) Go hunting in sequence databases but watch out for the traps. Trends in Genetics 12(10):425-427.
Bradford, Marion M. (1976) A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding. Analytical Biochemistry 72(1-2):248-254.
Breinan et al., "Autologous Chondrocyte Implantation in a Canine Model: Change in Composition of Reparative Tissue with Time", Journal of Orthopaedic Research, 2001; 19:482-492.
Breinan et al., "Effect of Cultured Autologous Chondrocytes on Repair of Chondral Defects in a Canine Model", Journal of Bone and Joint Surgery [Am], Oct. 1997; vol. 79-A, No. 10, 1439-1451.
Brenner, Steven E. (1999) Errors in genome annotation. Trends in Genetics 15(4):132-133.
Brighton et al., "Articular Cartilage Preservation and Storage-I. Application of Tissue Culture Techniques to the Storage of Viable Articular Cartilage", Arthritis and Rheumatism, vol. 22, No. 10 (Oct. 1979), pp. 1093-1101.
Brittberg et al., "Autologous Chondrocytes Used for Articular Cartilage Repair: An Update", Clinical Orthopaedics and Related Research, 2001; No. 391 Suppl: S337-S348.
Brittberg et al., "Rabbit Articular Cartilage Defects Treated with Autologous Cultured Chondrocytes", Clinical Orthopaedics and Related Research, 1996; 326:270-283.
Brittberg et al., "Treatment of Deep Cartilage Defects in the Knee with Autologous Chondrocyte Transplantation", New England Journal of Medicine, Oct. 6, 1994, vol. 331, No. 14, pp. 889-895.
Buckwalter et al., "Articular Cartilage: Degeneration and Osteoarthritis, Repair, Regeneration, and Transplantation", AAOS Instructional Course Lectures, 1998; 47:487-504.
Buckwalter, "Articular Cartilage Injuries", Clinical Orthopaedics and Related Research, 2002, No. 402, pp. 21-37.
Bugbee, "Fresh Osteochondral Allografting", Operative Techniques in Sports Medicine, Apr. 2000, vol. 8, No. 2, pp. 158-162.
Burger et al., "Fibrobblast growth factor receptor-1 is expressed by endothelial progenitor cells", Blood, vol. 100, No. 10 (Nov. 15, 2002) 3527-35.
Bursac, "Collagen Network Contributions to Structure-Function Relationships in Cartilaginous Tissues in Compression" (Dissertation), Boston University College of Engineering, 2002.
Cappellen, David et al., (1999) Frequent activating mutations of FGFR3 in human bladder arid cervix carcinomas. Nature Genetics 23(1):18-20.
Carr, M. E. Jr. and Alving, B. M. (1995) Effect of fibrin structure on plasmin-mediated dissolution of plasma clots. Blood Coag. Fibrinol. 6(6):567-573.
Carr, Marcus E. (1988) Fibrin formed in plasma is composed of fibers more massive than those formed from purified fibrinogen. Thromb. Haemost. 59(3):535-539.
Chen et al., "Repair of Articular Cartilage Defects: Part I. Basic Science of Cartilage Healing", The American Journal of Orthopedics, Jan. 1999, pp. 31-33.
Chen et al., "Repair of Articular Cartilage Defects: Part II. Treatment Options", The American Journal of Orthopedics, Feb. 1999, pp. 88-96.
Cheng, et al, "Chondrogenic Differentiation of Adipose-Derived Adult Stem Cells by a Porous Scaffold Derived from Native Articular Cartilage Extracellular Matrix", Tissue Engineering: Part A, vol. 15, No. 2. (2009), pp. 231-241.
Chusho, Hideki et al., (2001) Dwarfism and early death in mice lacking C-type Natriuretic Peptide. Proc Natl Acad Sci. 98(7):4016-4021.
Communication pursuant to Article 94(3) EPC for European Patent Application No. 08 782 728.3, dated Aug. 9, 2011.
Cook, James L. et al., (2003) Biocompatibility of three-dimensional chondrocyte grafts in large tibial defects of rabbits. Am J Vet Res. 64(1):12-20.
Coughlin, Shaun R. et al., (1988) Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo. J Biol Chem. 263(2):988-993.
Crescenzi et al., "Hyaluron Linear and Crosslinked Derivatives as Potential/Actual Biomaterials", in Hyaluronan (2002), vol. 1 (Chemical, Biochemical and Biological Aspects), J. F. Kennedy et al., Ed., pp. 261-268.
Dahlberg et al., "Demineralized Allogeneic Bone Matrix for Cartilage Repair", Journal of Orthopaedic Research, 1991, vol. 9, pp. 11-19.
Dell'Accio, Francesco et al., (2001) Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo, Arthritis Rheum. 44(7):1608-19.
Diduch et al., "Joint Repair: Treatment Options for Articular Cartilage Injury" Orthopedic Technology Review (2002) 4:24-27.
Doerks, Tobias et al., (1998) Protein annotation: detective work for function prediction. Trends Genet. 14(6):248-250.
Dvorakova, Dana et al., (2001) Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells British Journal Haematology 13(3):832-835.
Eriksson, A. Elisabeth et al., (1991) Three-dimensional structure of human basic fibroblast growth factor. Proc. Natl. Acad. Sci. USA 88:3441-3445 (XP002936511).
Ezzat Shereen et al., (2002) Targeted expression of A Human pituitary tumor-derived isoform of FGF Receptor-4 Recapitulates Pituitary Tumorigenesis. Journal of Clinical Investigation 109(1):69-77.
Faham, Salem et al., (1998) Diversity does make a difference: fibroblast growth factor—Heparin interactions. Curr Opin Struct Biol 8(5):578-586.
Feczko et al., "Experimental Results of Donor Site Filling for Autologous Osteochondral Mosaicplasty", Arthroscopy: The Journal of Arthroscopic and Related Surgery, vol. 19, No. 7 (Sep. 2003), pp. 755-761.
Final Office Action for U.S. Appl. No. 11/081,103, mailed Aug. 11, 2010.
Final Office Action for U.S. Appl. No. 12/381,072, mailed Jun. 27, 2011.
Final Office Action mailed Mar. 22, 2010 in connection with U.S. Appl. No. 12/010,984.
Final Office Action mailed Oct. 9, 2007 in connection with U.S. Appl. No. 11/151,270.
Fingl, Edward and Woodbury, Dixon M. (1975) General Principles. In: The Pharmacological Basis of Therapeutics. Fifth edition. Goodman, Louis S. and Gilman, Alfred editors. 1:1-45.
First Action Interview Pilot Pre-Interview Communication for U.S. Appl. No. 12/931,427, mailed Aug. 19, 2011.
First Action Interview Pilot Program Pre-Interview Communication for U.S. Appl. No. 12/696,366, mailed Oct. 13, 2011.
Fujisato et al. (1996) Effect of basic fibroblast growth factor on cartilage regeneration in chondrocyte-seeded collagen sponge scaffold. Biomaterials, vol. 17, No. 2, pp. 155-162.
Gao, Jizong et al. (2002) Repair of osteochondral defect with tissue-engineered two-phase composite material of injectable calcium phosphate and hyaluronan sponge, Tissue Engin. 13(5):827-837.
Gargiulo, B. J. et al., (2002) Phenotypic modulation of human articular chondrocytes by bistratene A. Eur Cell Mater. 3:9-18.
Gertzman et al., "A pilot study evaluating sodium hyaluronate as a carrier for freeze-dried demineralized bone powder", Cell and Tissue Banking, vol. 2, 2001, pp. 87-94.
Gilbert, et al., "Decellularization of Tissues and Organs", Biomaterials (2006) 27:3675-3683.
Girotto et al., "Tissue-specific gene expression in chondrocytes grown on three-dimensional hyaluronic acid scaffolds", Biomaterials, vol. 24 (2003), pp. 3265-3275.
Givol, David and Yayon, Avner (1992) Complexity of FGF receptors: genetic basis for structural diversity and functional specificity FASEB J. 6(15):3362-3369.
Glowacki, Julie, "Engineered Cartilage, Bone, Joints and Menisci-Potential for Temporomandibular Joint Reconstruction", Cells Tissues Organs, vol. 169, Issue 3, 2001, pp. 302-308.
Gooch et al., "IGF-I and Mechanical Environment Interact to Modulate Engineered Cartilage Development", Biochemical and Biophysical Research Communications, 2001; 286:909-915.
Gruber, Reinhard et al., (2002) Platelets stimulate proliferation of bone cells: involvement of platelet-derived growth factor, microparticles and membranes. Clin Oral Implants Res. 13(5):529-535.
Guilak, Farshid; "Functional Tissue Engineering: The Role of Biomechanics in Articular Cartilage Repair", Clinical Orthopaedics and Related Research, No. 391 S, pp. S295-S305, (c) 2001 Lipponcott Williams & Wilkins, Inc., (11 pages).
Haisch, A. et al., (2000) Preparation of a pure autologous biodegradable fibrin matrix for tissue engineering. Med Biol Eng Comput. 38(6):686-689.
Hecht, H. J. et al., (2000) Structure of fibroblast growth factor 9 shows a symmetric dimmer with unique receptor-and heparin-binding interfaces. Acta Cryst. D57:378-384.
Hoffman, "Hydrogels for Biomedical Applications", Advanced Drug Delivery Reviews, 2002, vol. 43, pp. 3-12.
http://www.stoneclinic.com/articularcartilagepastegrafting (Copyright 2009).
http://www.technobusiness-solutions.com/article-lyophilization1.html (published Feb. 12, 2002).
Hunziker, "Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable?", Osteoarthritis and Cartilage 7 (1999) pp. 15-28.
Hunziker, "Articular Cartilage Repair: Basic Science and Clinical Progress. A Review of the Current Status and Prospects", Osteoarthritis and Cartilage 2001, vol. 10, No. 6, pp. 432-463.
Hunziker, "Articular Cartilage Structure in Humans and Experimental Animals", Articular Cartilage and Osteoarthritis, Raven Press, ed., 2001, pp. 183-199.
International Cartilage Repair Society, "Cartilage Injury Evaluation Package", www.cartilage.org, 2000.
International Preliminary Report on Patentability for International Patent Application No. PCT/US2004/010956, issued on Nov. 18, 2005.
International Preliminary Report on Patentability for International Patent Application No. PCT/US2004/010957, issued on Nov. 18, 2005.
International Preliminary Report on Patentability for International Patent Application No. PCT/US2005/008798, issued on Nov. 1, 2006.
International Preliminary Report on Patentability for International Patent Application No. PCT/US2005/030610, issued on Feb. 26, 2008.
International Preliminary Report on Patentability for International Patent Application No. PCT/US2005/036878, issued on Apr. 17, 2007.
International Preliminary Report on Patentability for International Patent Application No. PCT/US2008/051796, issued on Jul. 28, 2009.
International Preliminary Report on Patentability for International Patent Application No. PCT/US2010/000108, mailed Jul. 28, 2011.
International Preliminary Report on Patentability for PCT/US2009/001459, mailed on May 12, 2010.
Itokazu, M. et al., (1997) The sustained release of antibiotic from freeze-dried fibrin-antibioticcompound and efficacies in a rat model of osteomyelitis. Infection 25(6):359-363.
Jackson et al., "Cartilage Substitute: Overview of Basic Science & Treatment Options", Journal of American Academy of Orthopaedic Surgeons, vol. 9, Jan./Feb. 2001, pp. 37-52.
Johnson, Daniel E. and Williams, Lewis T. (1993) Structural and functional diversity in the FGF receptor multigene family. Adv Cancer Res. 60:1-41.
Kato et al., "Fibroblast Growth Factor is an Inhibitor of Chondrocyte Terminal Differentiation", Journal of Biological Chemistry, vol. 265, No. 10 (Apr. 5, 1990) pp. 5903-5909.
Kirikoshi, Hiroyuki et al., (2000) Molecular cloning and characterization of Human FGF-20 on chromosome 8p21.3-p22. Biochem Biophys Res Commun. 274(2):337-343.
Kuroda, S. et al., (1999) Anabolic effect of aminoterminally truncated Fibroblast Growth Factor 4 (FGF4) on bone. Bone 25(4):431-437.
Lin et al. "The Chondrocyte: Biology and Clinical Application", Tissue Engineering, vol. 12, No. 7, (2006), pp. 1971-1984.
Loeser et al., "Basic Fibroblast Growth Factor Inhibits the Anabolic Activity of Insulin-like Growth Factor 1 and Osteogenic Protein 1 in Adult Human Articular Chondrocytes", Arthritis & Rheumatism, vol. 52, No. 12 (Dec. 2005), pp. 3910-3917.
Lu et al., "Minced Cartilage without Cell Culture Serves as an Effective Intraoperative Cell Source for Cartilage Repair", Journal of Orthopaedic Research, Jun. 2006, vol. 24, pp. 1261-1270.
Madry et al., "Gene Transfer of a Human Insulin-like Growth Factor I cDNA Enhances Tissue Engineering of Cartilage", Human Gene Therapy, 13: 1621-1630 (Sep. 1, 2002).
Mahadev et al., "Autogenous Osteochondral Morselised Grafts for Full Thickness Osteochondral Defects in the Knee Joints of Pigs", Singapore Medical Journal, 2001, vol. 42(9), pp. 410-416.
Matsuda et al. (1995) In Vivo Chondrogenesis in Collagen Sponge Sandwiched by Perichondrium. J. Biomater. Sci. Polymer Ed., vol. 7, No. 3, pp. 221-229.
Mazué et al., "Preclinical and Clinical Studies with Recombinant Human Basic Fibroblast Growth Factor", Annals New York Academy of Sciences, (1991) 329-340.
Messner et al., "Cartilage Repair: A Critical Review", Acta Orthopaedica Scandinavica, 1996, vol. 67, No. 5, pp. 523-529.
Messner et al., "The Long-term Prognosis for Severe Damage to Weight-bearing Cartilage in the Knee: A 14-year Clinical and Radiographic Follow-up in 28 Young Athletes", Acta Orthopaedica Scandinavica, 1996, vol. 67, No. 2, pp. 165-168.
Michielen et al., "Novel Biomaterials Based on Cross-linked Hyaluronon: Structural Investigations", in Hyaluronan (2002), vol. 1 (Chemical, Biochemical and Biological Aspects), J. F. Kennedy et al., Ed., pp. 269-276.
Nakatake, Yuhki et al., (2001) Identification of a novel fibroblast growth factor. FGF-22, preferentially expressed in the inner root sheath of the hair follicle. Biochim Biophys Acta. 1517(3):460-463.
Nehrer et al., "Chondrocyte-seeded Collagen Matrices Implanted in a Chondral Defect in a Canine Model", Biomaterials, 1998; 19:2313-2328.
Nettles et al., "In Situ Crosslinkable Hyaluronan For Articular Cartilage Repair", 50th Annual Meeting of the Orthopaedic Research Society, Paper No. 0202 (Mar. 2004).
Nettles et al., "Photocrosslinkable Hyaluronan as a Scaffold for Articular Cartilage Repair", Annals of Biomedical Engineering, vol. 32, No. 3, Mar. 2004, pp. 391-397.
Newman, "Articular Cartilage Repair", American Journal of Sports Medicine, 1998, vol. 26, No. 2, pp. 309-324.
Ngo, J. Thomas et al., (1994) Computational complexity, protein structure prediction, and the Levithal Paradox. In: The Protein Folding Problem and Tertiary Structure Prediction. K. Merz Jr. and S. Le Grand, Editors. 433-506 see also table of contents.
Nishimura, Tetsuya et al., (2000) Identification of a Novel FGF, FGF-21, Preferentially Expressed In The Liver. Biochim Biophys Acta 1492(1):203-206.
Nixon et al., "Enhanced Repair of Extensive Articular Defects by Insulin-like Growth Factor-I-Laden Fibrin Composites", Journal of Orthopaedic Research, 1999; 17:475-487.
Nixon et al., "New Horizons in Articular Cartilage Repair", Proceedings of the Annual Convention of the AAEP, 2001, vol. 47, pp. 217-226.
Nolan et al., "Living Bone Grafts", BMJ, vol. 304, Jun. 13, 1992, pp. 1520 and 1521.
Non-final Office Action for U.S. Appl. No, 12/924,132, mailed Jul. 18, 2011.
Non-final Office Action for U.S. Appl. No. 11/081,103, mailed Nov. 28, 2011.
Non-Final Office Action for U.S. Appl. No. 12/010,984, mailed Aug. 16, 2010.
Non-final Office Action for U.S. Appl. No. 12/043,001, mailed May 11, 2011.
Non-final Office Action for U.S. Appl. No. 12/179,034, mailed Jun. 29, 2011.
Non-final Office Action for U.S. Appl. No. 12/322,996, mailed Apr. 4, 2011.
Non-final Office Action for U.S. Appl. No. 12/508,892, mailed Dec. 7, 2011.
Non-final Office Action for U.S. Appl. No. 12/881,988, mailed Oct. 26, 2011.
Non-Final Office Action mailed Apr. 12, 2010 in connection with U.S. Appl. No. 12/191,490.
Non-Final Office Action mailed Apr. 15, 2010 in connection with U.S. Appl. No. 11/657,042.
Non-Final Office Action mailed Apr. 15, 2010 in connection with U.S. Appl. No. 12/079,629.
Non-final Office Action mailed Apr. 19, 2007 in connection with U.S. Appl. No. 11/151,270.
Non-Final Office Action mailed Apr. 26, 2010 in connection with U.S. Appl. No. 12/147,042.
Non-final Office Action mailed Aug. 19, 2009 in connection with U.S. Appl. No. 12/147,042.
Non-final Office Action mailed Dec. 18, 2007 in connection with U.S. Appl. No. 11/081,103.
Non-final Office Action mailed Feb. 20, 2007 in connection with U.S. Appl. No. 10/960,960.
Non-final Office Action mailed Feb. 6, 2007 in connection with U.S. Appl. No. 10/438,883.
Non-final Office Action mailed Feb. 7, 2008 in connection with U.S. Appl. No. 10/815,778.
Non-final Office Action mailed Jan. 14, 2010 in connection with U.S. Appl. No. 11/081,103.
Non-final Office Action mailed Jul. 2, 2009 in connection with U.S. Appl. No. 10/815,778.
Non-final Office Action mailed Jul. 22, 2009 in connection with U.S. Appl. No. 12/010,984.
Non-final Office Action mailed Jul. 9, 2008 in connection with U.S. Appl. No. 11/151,270.
Non-final Office Action mailed Jun. 3, 2009 in connection with U.S. Appl. No. 11/081,103.
Non-final Office Action mailed May 18, 2009 in connection with U.S. Appl. No. 11/657,042.
Non-final Office Action mailed May 3, 2005 in connection with U.S. Appl. No. 10/438,883.
Non-final Office Action mailed Nov. 12, 2008 in connection with U.S. Appl. No. 10/438,883.
Non-final Office Action mailed Nov. 5, 2004 in connection with U.S. Appl. No. 10/438,883.
Non-final Office Action mailed Oct. 5, 2005 in connection with U.S. Appl. No. 10/424,765.
Non-final Office Action with regard to U.S. Appl. No. 12/381,072, mailed Jan. 20, 2011.
Non-final Office Action with regard to U.S. Appl. No. 12/924,132, mailed Mar. 1, 2011.
Obradovic et al., "Integration of Engineered Cartilage", Journal of Orthopaedic Research, 19:1089-1097, 2001.
Okada-Ban, Mai et al., (2000) Fibroblast growth factor-2. International Journal of Biochemistry & Cell Biology 32 (3):263-267.
Olsen, Shaun K. (2003) Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. J Biol Chem. 278(36):34226-342236.
Ornitz et al., "Protein Family Review: Fibroblast Growth Factors", Genome Biology (2001) 2(3): reviews 3005.1-3005.12, available at http://genomebiology.com/2001/2/3/reviews/3005.1.
Ornitz, David M. (2000) FGFs, heparan sulfate and FGFRs: Complex interactions essential for development. Bio Essays 22:108-112.
Ornitz, David M. et al., (1996) Receptor specificity of the fibroblast growth factor family. J Biol Chem. 271(25)1 5292-7.
OsteoSponge product information, Bacterin International Inc., May 2005.
Pearson et al. (eds.), American Association of Tissue Banks, Standards for Tissue Banking, 2008 (12th ed.), pp. 53-56, 86-88.
Pei et al., "Bioreactors Mediate the Effectiveness of Tissue Engineering Scaffolds", The FASEB Journal, 16:1691-1694, published online (Aug. 7, 2002), 10.1096/fj.02-0083fje.
Pei et al., "Growth Factors for Sequential Cellular De- and Re-differentiation in Tissue Engineering", Biochemical and Biophysical Research Communications, 2002; 294:149-154.
Pellegrini, Luca et al., (2000) Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. Nature 407(6807):1029-1034.
Peretti et al., "A Biomedical Analysis of an Engineered Cell-Scaffold Implant for Cartilage Repair", Annals of Plastic Surgery, 2001, vol. 46, No. 5, pp. 533-537.
Peretti et al., "Biomechanical Analysis of a Chondrocyte-Based Repair Model of Articular Cartilage", Tissue Engineering, Aug. 1, 1999, vol. 5. No. 4, pp. 317-326.
Peretti et al., "Bonding of Cartilage Matrices with Cultured Chondrocytes: An Experiential Model", Journal of Orthopedic Research, Jan. 1998, vol. 16, No. 1, pp. 89-95.
Peretti et al., "Cell-Based Bonding of Articular Cartilage: An Extended Study", Journal of Biomedical Materials Research, 64A, 2003, pp. 517-524.
Peretti et al., "Cell-based Tissue-Engineered Allogeneic Implant for Cartilage Repair" Tissue Engineering, 2000, vol. 6. No. 5, pp. 567-576.
Peretti et al., "In Vitro Bonding of Pre-seeded Chondrocyte", Sport Sciences for Health, May 1, 2007, vol. 2, No. 1, pp. 29-33.
Peterson et al., "Autologous Chondrocyte Transplantation: Biomechanics and Long-term Durability", American Journal of Sports Medicine, 2002, vol. 30, No. 1, pp. 2-12.
Peterson et al., "Two- to 9-year Outcome After Autologous Chondrocyte Transplantation of the Knee", Clinical Orthopaedics and Related Research, 2000; No. 374: 212-234.
Pillai, Omathanu and Panchagnula, Ramesh (2001) Polymers in drug delivery. Curr Opin Chem Biol 5 (4):447-451.
Plotnikov, Alexander N. et al., (1999) Structural basis for FGF receptor dimerization and activation. Cell 98 (5):641-650.
Plotnikov, Alexander N. et al., (2000) Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell 101(4): 413-424.
Richardson et al., "Repair of Human Articular Cartilage After Implantation of Autologous Chondrocytes", Journal of Bone and Joint Surgery [Br], 1999; 81-B:1064-1068.
Sahni, Malika et al., (1999) FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway Genes Deve1.13(11):1361-1366.
Schaefer et al., "Tissue Engineered Composites for the Repair of Large Osteochondral Defects", Arthritis & Rheumatism, 46(9): 2524-2534 (2002).
Schlessinger, Joseph et al., (2000) Crystal structure of a ternary FGF-FGFR-1 Heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol Cell 6(3):743-750.
Schmal, H. et al., (2007) bFGF influences human articular chondrocyte differentiation. Cytotherapy 9(2):184-93.
Search Report and Written Opinion for International Patent Application No. PCT/US2004/010957, issued on Nov. 1, 2004.
Search Report and Written Opinion for International Patent Application No. PCT/US2005/008798, issued on Jun. 19, 2006.
Search Report and Written Opinion for International Patent Application No. PCT/US2005/030610, issued on Apr. 7, 2006.
Search Report and Written Opinion for International Patent Application No. PCT/US2005/036878, issued on Sep. 21, 2006.
Search Report and Written Opinion for International Patent Application No. PCT/US2005/051796, issued on Jun. 23, 2009.
Search Report and Written Opinion for International Patent Application No. PCT/US2008/085522, issued on Jul. 6, 2009.
Search Report and Written Opinion for International Patent Application No. PCT/US2009/001459, issued on Jul. 6, 2009.
Search Report and Written Opinion for International Patent Application No. PCT/US2010/085522, issued Jan. 14, 2010.
Search Report andf Written Opinion for International Patent Application No. PCT/US2004/010956, issued on Oct. 28, 2005.
Sedgwick et al., "Studies into the influence of carrageenan-induced inflammation on articular cartilage degradation using implantation into air pouches", British Journal of Experimental Pathology, vol. 66, (1985), pp. 445-453.
Seno, Masaharu et al., (1990) Carboxyl-terminal structure of basic fibroblast growth factor significantly contributes to its affinity for Heparin. Eur J Biochem. 188:239-245.
Shao, Zhang-Qiang et al., (2006) Effects of intramyocardial administration of slow-release basic fibroblast growth factor on angiogenesis and ventricular remodeling in a rat infarct model. Circ. J. 70(4):471-477.
Sims, C. Derek et al., (1998) Tissue engineered neocartilage using plasma derived polymer substrates and chondrocytes. Plastic & Recon. Surg. 101(6):1580-1585.
Skolnik, Jeffrey and Fetrow, Jacquelyn S. (2000) From genes to protein structure and function: novel applications of computational approaches in the genomic era. Trends BioTechnol. 18(1):34-39.
Sleeman, Matthew et al., (2001) Identification of a new fibroblast growth factor receptor, FGFR5. Gene 271 (2):171-182.
Smith, Temple and Zhang, Xiaolin (1997) The challenges of genome sequence annotation or The devil is in the details. Nat Biotechnol. 15(12):1222-1223.
Spangenberg, Kimberly, M., et al. "Histomorphometric Analysis of a Cell-Based Model of Cartilage Repair", Tissue Engineering, vol. 8, No. 5, 2002, (8 pages).
Springer, Barry A. et al., (1994) Identification and Concerted Function of Two Receptors Binding Surfaces on Basic Fibroblast Growth Factor Required for Mitogenesis. The Journal of Biological Chemistry 269(43):26879-26884.
Stauber, Deborah J. et al., (2000) Structural interactions of fibroblast growth factor receptor with its ligands. Proc Natl Acad Sci USA 97(1):49-54.
Stone et al., "Articular Cartilage Paste Grafting to Full-Thickness Articular Cartilage Knee Joint Lesions: A 2- to 12-Year Follow-up", Arthroscopy: The Journal of Arthoscopic and Related Surgery, Mar. 2006, vol. 22, No. 3, pp. 291-299.
Stone et al., "One-Step American Technique of Articular Cartilage Paste Grafting to Traumatic and Arthritic Defects in the Knee Joint (2-7 Years Follow-Up)", downloaded from http:web.archive.org/web/20041205005845/http://www.stoneclinic.com/onestep.thm; published Dec. 5, 2004.
Supplemental Search report for European Patent Application No. 05728956.3, dated May 2, 2011.
Temenoff et al., "Review: Tissue engineering for regeneration of articular cartilage", Biomaterials 21 (2000) pp. 431-440.
Trzeciak et al., "Evaluation of Cartilage Reconstruction by Means of Autologous Chondrocyte Versus Periosteal Graft Transplantation: An Animal Study", Transplantation Proceedings, vol. 38 (2006), pp. 305-311.
Tsumaki et al. "Role of CDMP-1 in Skeletal Morphogenesis: Promotion of Mesenchymal Cell Recruitment and Chondrocyte Differentiation", J. Cell Biol., Jan. 1999, vol. 144, No. 1, 161-173.
U.S. Appl. No. 12/147,042, based on U.S. Patent No. 7,067,123, filed Jun. 26, 2008, entitled: "Novel Glue for Cartilage Repair".
U.S. Appl. No. 12/881,988, filed Sep. 14, 2010.
U.S. Appl. No. 12/924,132, filed Sep. 21, 2010.
U.S. Appl. No. 13/025,722, filed Feb. 11, 2011.
Umlauf et al., "Cartilage biology, pathology, and repair", Cell. Mol. Life Sci., vol. 67, (2010), pp. 4197-4211.
Vajo, Zoltan et al., (2000) The Molecular and Genetic Basis of Fibroblast Growth Factor Receptor 3 Disorders: The Achondroplasia Family of Skeletal Dysplasias, Muenke Craniosynostosis, and Crouzon Syndrome with Acanthosis Nigricans. Endocrine Rev. 21(1):23-39.
Verbruggen et al., "Repair Function in Organ Cultured Human Cartilage. Replacement of Enzymatically Removed Proteoglycans During Longterm Organ Culture", The Journal of Rheumatology, 12:4, (1985), pp. 665-674.
Vunjak-Novakovic et al., "Bioreactor Cultivation Conditions Modulate the Composition and Mechanical Properties of Tissue-Engineered Cartilage", Journal of Orthopaedic Research, 1999; 17:130-138.
Wells, James A. (1990) Additivity of mutational effects in proteins. Biochemistry 29(37):8509-8517.
Yamashita, Tetsuo et al., (2000) Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochemical and Biophysical Research Communications 277(2):494-498.
Yayon, Avner et al., (1991) Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 64(4):841-848.
Yee, Cindy J. et al., (2000) Analysis of fibroblast growth factor receptor 3 S249C mutation in cervical carcinoma. Journal of the National Cancer Institute 92(22):1848-1849.
Zhang, Jiandong et al., (1991) Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 Beta. Proc Natl Acad Sci. USA 88(8):3446-3450.
Zhu, Hengyi et al., (1995) Glu-96 of basic fibroblast growth factor is essential for high affinity receptor binding. Journal Of Biological Chemistry 270(37):21869-21874.
Zhu, Hengyi et al., (1997) Analysis of high-affinity binding determinants in the receptor binding epitope of basic fibroblast growth factor. Protein Engineering 10(4):417-421.

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