USRE42126E1 - Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip - Google Patents
Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip Download PDFInfo
- Publication number
- USRE42126E1 USRE42126E1 US10/927,655 US92765500A USRE42126E US RE42126 E1 USRE42126 E1 US RE42126E1 US 92765500 A US92765500 A US 92765500A US RE42126 E USRE42126 E US RE42126E
- Authority
- US
- United States
- Prior art keywords
- oral care
- delivery system
- oral
- backing strip
- care composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *[Si](*)(C)OC.C.C Chemical compound *[Si](*)(C)OC.C.C 0.000 description 2
- QEGNUYASOUJEHD-UHFFFAOYSA-N CC1(C)CCCCC1 Chemical compound CC1(C)CCCCC1 QEGNUYASOUJEHD-UHFFFAOYSA-N 0.000 description 1
- WWMZHVZKIANCHO-UHFFFAOYSA-N CNC(=C#N)NCCSCC1=C(C)NC=N1 Chemical compound CNC(=C#N)NCCSCC1=C(C)NC=N1 WWMZHVZKIANCHO-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C19/00—Dental auxiliary appliances
- A61C19/06—Implements for therapeutic treatment
- A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
- A61K6/69—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/70—Preparations for dentistry comprising inorganic additives
- A61K6/78—Pigments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
- A61K8/70—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine containing perfluoro groups, e.g. perfluoroethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
Definitions
- the present invention relates to a delivery system for applying and delivering an oral care substance or composition to oral surfaces including the tooth enamel.
- the composition forms a film on the surface to which it has been applied and provides sustained release of the oral care substance from the film for prolonged therapeutic, prophylactic, and/or cosmetic benefits.
- the present invention relates to systems comprising a removable backing strip to facilitate the application of compositions comprising organosiloxane resins for delivering oral care substances to the tooth enamel.
- the compositions herein may further provide sustained release benefits to other oral surfaces, such as the gingival and mucosal tissues, as well as to the surfaces of the teeth.
- Oral care products by which various oral care substances or actives can be delivered to the soft and hard tissues of the oral cavity have previously been known.
- oral care products include, for example, brushing aids such as dentifrice products for delivery of anti-caries actives such as fluoride or other actives for the reduction of the bacteria that lead to the formation of plaque, and mouthwashes containing breath freshening actives and/or anti-bacterial actives.
- bleaching agents such as peroxide that can be applied directly to the surfaces of the teeth, i.e., to the tooth enamel, have been developed.
- the above systems are water-soluble, i.e., they are readily dissolved by saliva, generally within about 1-3 hours after application. Therefore, their degree of durability is low, and they cannot provide long-term delivery of the active ingredient that is present in the composition.
- their water-soluble nature precludes them from being used with oral care actives that would be unstable in water-based films.
- Sodium percarbonate is one example of such an active; it would be unstable in the high pH environment of an aqueous-based film.
- barrier coating may offer a benefit in terms of enhanced durability, it requires the use of special equipment and complex application; thus, it cannot be performed at home and cannot be used for self-treatment.
- the present invention is directed to a delivery system for delivering an oral care substance to the oral cavity, the delivery system comprising: (a) a removable backing strip having sufficient flexibility so as to be readily conformable to an oral surface when the delivery system is placed thereagainst; and (b) an oral care composition applied to the strip of material such that when the delivery system is placed on the oral surface the oral care composition contacts the oral surface, the oral care composition comprising: (i) an organosiloxane resin; (ii) a rheology modifier; and (iii) at least one oral care substance; wherein the oral care composition remains on the oral surface after the backing strip is removed.
- the present invention is also directed to such systems in which the oral care composition further comprises fluid diorganopblysiloxane-based polymers.
- Such compositions may further comprise carriers for solubilizing the organosiloxane resin and the fluid diorganopolysiloxane-based polymers.
- the present invention is still further directed to methods of using the delivery systems herein.
- FIG. 1 is a perspective view of a substantially flat backing strip of material
- FIG. 2 is a perspective view of an embodiment of the present invention, disclosing the flat backing strip of FIG. 1 coated with an oral care substance for treating teeth and/or gums;
- FIG. 3 is a cross-sectional view thereof, taken along section line 3 — 3 of FIG. 2 , disclosing an example of the flat backing strip having a thickness less than that of the substance coated thereon;
- FIG. 4 is a cross-sectional view showing an alternative embodiment of the present invention, showing shallow pockets in the backing strip, which act as reservoirs for additional oral care substance coated on the strip;
- FIG. 5 is a cross-sectional plan view thereof, showing an alternative embodiment for applying oral care substances for treating teeth having the backing strip of the present invention conforming to the teeth and allowing application across typical dentition surfaces;
- FIG. 6 is a cross-sectional elevation view of a tooth, taken along section line 6 — 6 of FIG. 5 , disclosing the backing strip with oral care active of the present invention conforming to the tooth profile during application;
- FIG. 7 is a cross-sectional plan view, similar to FIG. 5 , showing a backing strip of the present invention conforming to the teeth and the adjoining soft tissue during application;
- FIG. 8 is a cross-sectional elevation view, taken along section line 8 — 8 of FIG. 7 , showing a backing strip of the present invention conforming to both the tooth and the adjoining soft tissue during application;
- FIG. 9 is a perspective view of an alternative embodiment of the present invention, disclosing the flat backing strip coated with an oral care substance of FIG. 2 for treating teeth and adjoining soft tissue having a release liner;
- FIG. 10 is a cross-sectional view of an alternative embodiment of the present invention, taken along section line 10 — 10 of FIG. 9 , showing a release liner attached to the backing strip by the oral care substance on the strip of material;
- FIG. 11 shows an example of applying the delivery system of the present invention onto the teeth by peeling the backing strip away from the teeth.
- centimeter means centimeter.
- mm means millimeter.
- FIGS. 1 and 2 there is shown a first preferred embodiment of the present invention, generally indicated as 10 , representing a delivery system for applying and delivering an oral care composition to an oral surface.
- Delivery system 10 has a backing strip of material 12 , which is initially substantially flat.
- oral care composition 14 Applied or coated onto the backing strip 12 is an oral care composition 14 , as described herein.
- the oral care composition 14 is homogeneous, uniformly and continuously coated onto the backing strip 12 , as shown in FIG. 3 .
- oral care composition 14 may alternatively be a laminate or separated layers of components, an amorphous mixture of components, separate stripes or spots or other patterns of different components, or a combination of these structures including a continuous coating of oral care composition 14 along a longitudinal axis of a portion of the backing strip 12 .
- a backing strip 12 may have shallow pockets 18 formed therein.
- additional oral care composition 14 fills shallow pockets 18 to provide reservoirs of additional oral care composition 14 .
- FIGS. 5 and 6 show a delivery system 24 of the present invention conformed to a surface of a tooth and plurality of adjacent teeth during the application of the delivery system herein.
- Embedded in adjacent soft tissue 20 are a plurality of adjacent teeth 22 .
- Adjacent soft tissue is herein defined as soft tissue surfaces surrounding the tooth structure including: papilla, marginal gingiva, gingival sulculus, inter dental gingiva, gingival gum structure on lingual and buccal surfaces up to and including muco-ginival junction and the pallet.
- delivery system 24 represents a backing strip 12 and an oral care composition 14 , with oral care composition 14 on the side of the backing strip 12 the is facing tooth 22 .
- Oral care composition 14 may be pre-applied to the backing strip 12 , or may be applied to the backing strip 12 by the delivery system user.
- the backing strip 12 has a thickness and flexural stiffness which enable it to conform to the contoured surfaces of tooth 22 and to adjacent soft tissue 20 during application of the oral care composition 14 .
- the backing strip has sufficient flexibility to form to the contours of the oral surface, in this figure the surface being a plurality of adjacent teeth.
- the backing strip is also readily conformable to tooth surfaces and to the interstitial tooth spaces without permanent deformation during application.
- FIGS. 7 and 8 show a delivery system 24 of the present invention applied to both front and rear surfaces of a plurality of adjacent teeth 22 as well as to adjacent soft tissue 20 , during application of the oral care composition.
- Delivery system 24 represents a backing strip 12 and an oral care composition 14 , with oral care composition 14 on the side of backing strip 12 that is facing tooth 22 .
- FIGS. 9 and 10 show an optional release liner 27 .
- Release liner 27 is attached to the backing 12 by oral care composition 14 .
- Oral care composition 14 is on the side of the backing strip 12 that is facing the release liner 27 . This side is applied to the tooth and gum surfaces once the release liner 27 is removed.
- FIG. 11 shows an example of applying the delivery system of the present invention onto teeth.
- the oral care substances will be left on teeth surface after the backing strip is peeled off.
- Another example of applying the delivery system is to allow the backing strip to dissolve in-situ. In such an embodiment, there is no need to peel the backing strip away from the oral surfaces.
- the backing strip of material serves to carry the oral care compositions herein, and facilitates the application of the oral compositions to the oral surfaces.
- the backing strip is removable, i.e., it need not be worn in the oral cavity for the duration of the time that the oral care composition is present in the oral cavity.
- the term “removable” is intended to include manual removal of the backing strip, e.g., by peeling, as well as removal of the backing strip as a result of in-situ dissolution in the oral cavity, i.e., that occurs without the need for manual peeling.
- the backing strip of material may comprise polymers, natural and synthetic woven materials, non-woven material, foil, paper, rubber, and combinations thereof.
- the backing strip may be a single layer of material or a laminate comprised of more than one layer. Regardless of the number of layers, the backing strip is either substantially water soluble (dissolves in-situ) or substantially water insoluble.
- the strip may be removed by peeling immediately after application, see FIG. 11 , leaving the active materials adhering to the teeth and/or other oral surfaces, or removed after some time interval.
- the material is any type of polymer or combination of polymers that meet the required flexural rigidity and is compatible with oral care substances. Suitable polymers include, but are not limited to, polyethylene, ethylvinylacetate, polyesters, ethylvinyl alcohol, pullulan film, combinations thereof. Examples of polyesters include Mylar® and fluoroplastics such as Teflon®, both manufactured by DuPont. The preferable material is polyethylene.
- the backing strip is generally less than about 1 mm thick, preferably less than about 0.05 mm thick, and more preferably from about 0.001 to about 0.03 mm thick.
- a polyethylene backing strip is preferably less than about 0.1 mm thick and more preferably from about 0.005 to about 0.02 mm thick.
- the backing strip may also be comprised of a substantially water and/or saliva soluble material such as agar film, starch paper, rice paper, natural gum, pullulan paper, or mixtures thereof.
- a substantially water and/or saliva soluble material such as agar film, starch paper, rice paper, natural gum, pullulan paper, or mixtures thereof.
- the shape of the backing strip is any shape and size that covers the desired oral surface.
- the width of the backing strip will also depend upon the oral surface area to be covered. In one example, the width of the strip is from about 0.5 cm to about 4 cm and preferably from about 1 cm to about 2 cm.
- the backing strip may contain shallow pockets.
- additional oral care substance fills shallow pockets to provide reservoirs of additional oral care substance.
- the shallow pockets help to provide texture to the delivery system.
- the film will preferably have an array of shallow pockets. Generally, the shallow pockets are approximately 0.4 mm across and 0.1 mm deep.
- the overall thickness of the delivery system is generally less than about 1 mm. Preferably, the overall thickness is less than about 0.5 mm.
- the amount of oral care composition applied to the strip of material or oral surface depends upon the size and capacity of the piece of material, concentration of the active, and the desired benefit sought. Generally, less than about 1 gram of oral care substance is required. Preferably, from about 0.05 grams to about 0.5 grams and more preferably from about 0.1 gram to about 0.4 grams of the oral care substance is used.
- the amount of oral care substance per square cm of material is less than about 0.2 grams/cm 2 , preferably from about 0.005 to about 0.1 grams/cm 2 , and more preferably from about 0.01 grams/cm 2 to about 0.04 grams/cm 2 .
- the oral care composition of the present invention can be in the form of a viscous liquid, paste, gel, solution, or other suitable form that can provide sufficient adhesion.
- the oral care composition is in the form of an adhesive film.
- the oral care substance will have a viscosity of from about 200 to about 1,000,000 cps at low shear rates (less than one 1/seconds).
- the viscosity is from about 100,000 to about 800,000 cps and more preferably from about 400,000 to about 600,000 cps.
- One preferred embodiment of the oral composition herein is comprised of an organosiloxane resin; a rheology modifier; and at least one oral care substance.
- compositions are comprised of an organosiloxane resin; a fluid diorganopolysiloxane-based polymer; a rheology modifier; and at least one oral care substance.
- an oral care composition further comprises a carrier capable of solubilizing the organosiloxane resin and the fluid diorganopolysiloxane-based polymer.
- Silicone resins are highly crosslinked polymeric siloxane systems.
- the crosslinking is introduced through the incorporation of tri-functional and tetra-functional silanes with mono-functional or di-functional, or both, silanes during manufacture of the silicone resin.
- the degree of crosslinking that is required in order to result in a silicone resin will vary according to the specific silane units incorporated into the silicone resin.
- silicone materials which have a sufficient level of trifunctional and tetrafunctional siloxane monomer units, and hence, a sufficient level of crosslinking, such that they dry down to a rigid, or hard, film are considered to be silicone resins.
- the ratio of oxygen atoms to silicon atoms is indicative of the level of crosslinking in a particular silicone material.
- Silicone materials which have at least about 1.1 oxygen atoms per silicon atom will generally be silicone resins herein.
- the ratio of oxygen:silicon atoms is at least about 1.2:1.0.
- Silicone materials and silicone resins in particular can conveniently be identified according to a shorthand nomenclature system well known to those skilled in the art as the “MDTQ” nomenclature. Under this system, the silicone is described according to the presence of various siloxane monomer units which make up the silicone. Briefly, the symbol M denotes the mono-functional unit (CH 3 ) 3 SiO) 0.5 ; D denotes the difunctional unit (CH 3 ) 2 SiO; T denotes the trifunctional unit (CH 3 )SiO 1.5 ; and Q denotes the quadra- or tetra-functional unit SiO 2 . Note that a small amount, up to about 5% of silanol or alkoxy functionality may also be present in the resin structure as a result of processing.
- Primes of the unit symbols denote substituents other than methyl, and must be specifically defined for each occurrence. Typical alternate substituents include groups such as vinyl, phenyl, amino, hydroxyl, etc.
- the molar ratios of the various units either in terms of subscripts to the symbols indicating the total number of each type of unit in the silicone, or an average thereof, or as specifically indicated ratios in combination with molecular weight, complete the description of the silicone material under the MDTQ system. Higher relative molar amounts of T, Q, T′ and/or Q′ to D, D′, M and/or M′ in a silicone resin is indicative of higher levels of crosslinking. As discussed before, however, the overall level of crosslinking can also be indicated by the oxygen to silicon ratio.
- the organosiloxane resins are solid at about 25° C. and the average molecular weight of the resins is from about 1,000 to about 10,000.
- the resins are soluble in organic solvents such as toluene, xylene, isoparaffins, and cyclosiloxanes or the volatile carrier described below, indicating that the resin is not sufficiently crosslinked such that the resin is insoluble in the volatile carrier.
- the silicone resins preferred for use herein are MQ, MT, MTQ, and MDTQ resins; such MQ resins are disclosed in U.S. Pat. No. 5,330,747, Krzysik, issued Jul. 19, 1994.
- the preferred silicone substituent is methyl.
- MQ resins wherein the M:Q ratio is from about 0.5:1.0 to about 1.5:1.0.
- Organosiloxane resins such as these are commercially available, for example, Wacker 803 and 804 available from Wacker Silicones Corporation of Adrian, Mich., US, and G.E. 1170-002 from the General Electric Company.
- the level of the resin that is used in the compositions is dependent on its degree of solubility in the formulation, particularly in the solvents used. Generally, the range of resin used in the present invention is from about 5% to about 70%, preferably from about 15% to about 45%, and even more preferably from about 20% to about 40%.
- compositions of the present invention may further comprise a fluid diorganopolysiloxane-based polymer to be combined with the organosiloxane resins.
- Said fluid diorganopolysiloxane-based polymers useful in the present invention span a large range of viscosities; from about 10 to about 10,000,000 centistokes (cSt) at 25° C.
- Some diorganopolysiloxane polymers useful in this invention exhibit viscosities greater than 10,000,000 centistokes (cSt) at 25° C. and therefore are characterized by manufacturer specific penetration testing. Examples of this characterization are GE silicone materials SE 30 and SE 63 with penetration specifications of 500-1500 and 250-600 (tenths of a millimeter) respectively.
- diorganopolysiloxane polymers comprising repeating units, where said units correspond to the formula (R 2 SiO) n , where R is a monovalent hydrocarbon radical containing from 1 to 6 carbon atoms, preferably selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, amyl, hexyl, vinyl, allyl, cyclohexyl, amino alkyl, phenyl, fluoroalkyl and mixtures thereof.
- R is a monovalent hydrocarbon radical containing from 1 to 6 carbon atoms, preferably selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, amyl, hexyl, vinyl, allyl, cyclohexyl, amino alkyl, phenyl, fluoroalkyl and
- the fluid diorganopoylsiloxane polymers employed in the present invention may contain one or more of these hydrocarbon radicals as substituents on the siloxane polymer backbone.
- the fluid diorganopolysiloxane polymers may be terminated by triorganosilyl groups of the formula (R′ 3 Si) where R′ is a radical selected from the group consisting of monovalent hydrocarbons containing from 1-6 carbon atoms, hydroxyl groups, alkoxyl groups and mixtures thereof.
- R′ is a radical selected from the group consisting of monovalent hydrocarbons containing from 1-6 carbon atoms, hydroxyl groups, alkoxyl groups and mixtures thereof.
- the fluid diorganopolysiloxane polymer must be compatible in solution with the organosiloxane resin and the volatile carrier.
- compatible refers to the formation of a single phase solution when the fluid diorganopolysiloxane polymer, the organosiloxane resin and the volatile carrier are mixed together in ratios required for a specific formulation.
- the lower viscosity fluid diorganopolysiloxane polymers viscosity of about 10 to 100cSt.
- PDMS poly (dimethylsiloxane), herein referred to as PDMS or silicone gum
- volatile carriers other than ethanol are preferred.
- Silicone gum corresponds to the formula:
- Fluid diorganopolysiloxane polymers such as these are commercially available, for example, SE 30 silicone gum and SF96 silicone fluid available from the General Electric Company. Similar materials can also be obtained from Dow Coming and from Wacker Silicones.
- dimethicone copolyol to modify film forming characteristics as desired.
- the dimethicone copolyol can be further characterized as polyalkylene oxide modified polydimethysiloxanes, such as manufactured by the Witco Corporation under the trade name Silwet. Similar materials can be obtained from Dow Coming, Wacker Silicones and Goldschmidt Chemical Corporation as well as other silicone manufacturers.
- the ratio of organosiloxane resin to fluid diorganopolysiloxane polymer is preferably from about 10:1 to about 1:10, more preferably from about 2:1 to about 8:1, and still more preferably from about 4:1 to 6:1.
- compositions further comprise a rheology modifier which inhibits settling and separation of components or controls settling in a manner which facilitates re-dispersion and may control rheological flow properties for strip making.
- Suitable rheology modifiers herein include organo modified clays, silicas, polyethylene, and mixtures thereof.
- the preferred organophilic clays comprise quatemium-18 hectorite or Stearalkonium hectorite, such as Bentone 27 and 38TM from Rheox, organoclay dispersion such as Bentone ISD gelTM; or bentonite organo modified clays such as Bentone 34 TM from Rheox or the Claytone SeriesTM from Southern Clay Products; and mixtures thereof.
- the preferred silicas may be fumed silica such as the AerosilTM series from Degussa or the Cab-o-silTM series from Cabot Corporation, silica gels such as the Sylodent TM or SyloxTM series from W. R. Grace & Co. or precipitated silica such as Zeothix 265 from J. M. Huber Corporation.
- fumed silica such as the AerosilTM series from Degussa or the Cab-o-silTM series from Cabot Corporation
- silica gels such as the Sylodent TM or SyloxTM series from W. R. Grace & Co.
- precipitated silica such as Zeothix 265 from J. M. Huber Corporation.
- the rheology modifier is preferably present in the composition at a level of from about 0.1% to about 30%, preferably from about 0.5% to about 10%, and even more preferably about 1% to about 3% of the composition.
- the oral care compositions that comprise a fluid diorganosiloxane-based polymer may further comprise a carrier.
- the carrier may be used to solubilize the organosiloxane resin and the fluid diorganosiloxane-based polymer.
- the carrier is preferably comprised of a volatile component and a non-volatile component.
- the carrier comprises from about 0% to about 90%, preferably from about 0% to about 80%, and more preferably from about 0% to about 70%, of the composition.
- the carrier of the present invention is selected from the group consisting of hydrocarbon oils, volatile silicones, non-hydrocarbon solvents, and mixtures thereof.
- Hydrocarbon oils useful in the present invention include those having boiling points in the range of 60-260° C., more preferably hydrocarbon oils having from about C 8 to about C 20 chain lengths, most preferably C 8 to C 20 isoparaffins. Of these isoparaffins most preferred are selected from the group consisting of isododecane, isohexadecane, isoeocosane, 2,2,4-trimethylpentane, 2,3-dimethylhexane and mixtures thereof. Most preferred is isododecane, available as, for example, Pernethyl 99 A from Permethyl Corporation corresponding to the formula: CH 3 (CH 2 ) 10 CH 3
- Preferred volatile silicone fluids include cyclomethicones having 3 , 4 and 5 membered ring structures corresponding to the formula:
- non-hydrocarbon solvents useful herein include esters, ketones, alcohols, fluorocarbons and fluorocarbon ethers having boiling points in the range of 60 to 200° C.
- Non-hydrocarbon solvents or mixtures thereof particularly useful include those that are capable of-solubilizing the resin and/or the diorganopolysiloxane-based polymer.
- solvents include but are not limited to ethanol, acetone, butanone, ethyl acetate, propyl acetate, amyl acetate, ethyl butyrate, methyl nonafluoroisobutyl ether, methyl nonafluorobutyl ether, and mixtures thereof.
- non-hydrocarbon solvents are readily available such as ethyl acetate and methyl ethyl ketone, both supplied by J. T. Baker of Phillispburg, N.J, and HFE (a mixture of methyl nonafluoroisobutyl ether and methyl nonafluorobutyl ether), supplied by the 3M Company.
- the oral care substance preferably contains an active at a level where upon directed use, the benefit sought by the wearer is promoted without detriment to the oral surface to which it is applied.
- actives include, but, are not limited to, appearance and structural changes to teeth, whitening, stain bleaching, stain removal, plaque removal, tartar removal, cavity prevention and treatment, inflamed and/or bleeding gums, mucosal wounds, lesions, ulcers, aphthous ulcers, cold sores, tooth abscesses, and the elimination of mouth malodor resulting from the conditions above and other causes such as microbial proliferation.
- Suitable oral care substances include any material that is generally considered safe for use in the oral cavity and that provides changes to the overall appearance and/or health of the oral cavity.
- the level of oral care substance in the compositions of the present invention is generally, unless specifically noted, from about 0.01% to about 50%, preferably from about 0.1% to about 20%, more preferably from about 0.5% to about 10%, and even more preferably from about 1% to about 7%, by weight of the composition.
- Oral care compositions or substances of the present invention may include many of the actives previously disclosed in the art. The following is a non-limiting list of oral care actives that may be used in the present invention.
- Teeth whitening actives may be included in the oral care substance of the present invention.
- the actives suitable for whitening are selected from the group consisting of the peroxides, metal chlorites, perborates, percarbonates, peroxyacids, persulfates, and combinations thereof.
- Suitable peroxide compounds include hydrogen peroxide, urea peroxide, calcium peroxide, carbamide peroxide, and mixtures thereof. Most preferred is carbamide peroxide.
- Suitable metal chlorites include calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, and potassium chlorite. Additional whitening actives may be hypochlorite and chlorine dioxide.
- the preferred chlorite is sodium chlorite.
- a preferred percarbonate is sodium percarbonate.
- Preferred persulfates are oxones.
- Anti-tartar agents known for use in dental care products include phosphates.
- Phosphates include pyrophosphates, polyphosphates, polyphosphonates and mixtures thereof.
- Pyrophosphates are among the best known for use in dental care products. Pyrophosphate and polyphosphate ions are delivered to the teeth derive from pyrophosphate polyphosphate salts.
- the pyrophosphate salts useful in the present compositions include the dialkali metal pyrophosphate salts, tetra-alkali metal pyrophosphate salts, and mixtures thereof.
- Disodium dihydrogen pyrophosphate Na 2 H 2 P 2 O 7
- tetrasodium pyrophosphate Na 4 P 2 O 7
- tetrapotassium pyrophosphate K 4 P 2 O 7
- pyrophosphate salts any of the above mentioned pyrophosphate salts may be used, tetrasodium pyrophosphate salt is preferred.
- pyrophosphate salts are described in more detail in Kirk & Othmer, Encyclopedia of Chemical Technology, Third Edition, Volume 17, Wiley-lnterscience Publishers (1982). Additional anticalculus agents include pyrophosphates or polyphosphates disclosed in U.S. Pat. No. 4,590,066 issued to Parran & Sakkab on May 20, 1986; polyacrylates and other polycarboxylates such as those disclosed in U.S. Pat. No. 3,429,963 issued to Shedlovsky on Feb. 25, 1969 and U.S. Pat. No. 4,304,766 issued to Chang on Dec. 8, 1981; and U.S. Pat. No. 4,661,341 issued to Benedict & Sunberg on Apr.
- polyepoxysuccinates such as those disclosed in U.S. Pat. No. 4,846,650 issued to Benedict, Bush & Sunberg on Jul. 11, 1989; ethylenediaminetetraacetic acid as disclosed in British Pat. No. 490,384 dated Feb. 15, 1937; nitrilotriacetic acid and related compounds as disclosed in U.S. Pat. No. 3,678,154 issued to Widder & Briner on Jul. 18, 1972; polyphosphonates as disclosed in U.S. Pat. No. 3,737,533 issued to Francis on Jun. 5, 1973, U.S. Pat. No. 3,988,443 issued to Ploger, Schmidt-Dunker & Gloxhuber on Oct. 26, 1976 and U.S. Pat. No.
- Anticalculus phosphates include potassium and sodium pyrophosphates; sodium tripolyphosphate; diphosphonates, such as ethane-1-hydroxy-1,1-diphosphonate, 1-azacycloheptane-1,1-diphosphonate, and linear alkyl diphosphonates; linear carboxylic acids; and sodium zinc citrate.
- Agents that may be used in place of or in combination with the pyrophosphate salt include such known materials as synthetic anionic polymers including polyacrylates and copolymers of maleic anhydride or acid and methyl vinyl ether (e.g., Gantrez), as described, for example, in U.S. Pat. No.
- polyamino propoane sulfonic acid AMPS
- zinc citrate trihydrate polyphosphates (e.g., tnpolyphosphate; hexametaphosphate), diphosphonates (e.g., EHDP; AHP), polypeptides (such as polyaspartic and polyglutamic acids), and mixtures thereof.
- polyphosphates e.g., tnpolyphosphate; hexametaphosphate
- diphosphonates e.g., EHDP; AHP
- polypeptides such as polyaspartic and polyglutamic acids
- Fluoride ion sources are well known for use in oral care compositions as anticaries agents. Fluoride ions are contained in a number of oral care compositions for this purpose, particularly toothpastes. Patents disclosing such toothpastes include U.S. Pat. No. 3,538,230, Nov. 3, 1970 to Pader et al; U.S. Pat. No. 3,689,637, Sep. 5, 1972 to Pader; U.S. Pat. No. 3,711,604, Jan 16, 1973 to Colodney et al; U.S. Pat. No. 3,911,104, Oct. 7, 1975 to Harrison; U.S. Pat. No. 3,935,306, Jan. 27, 1976 to Roberts et al; and U.S. Pat. No. 4,040,858, Aug. 9, 1977 to Wason.
- fluoride ions to dental enamel serves to protect teeth against decay.
- fluoride ion-yielding materials can be employed as sources of soluble fluoride in the instant compositions. Examples of suitable fluoride ion-yielding materials are found in Briner et al; U.S. Pat. No. 3,535,421; issued Oct. 20, 1970 and Widder et al; U.S. Pat. No. 3,678,154; issued Jul. 18, 1972.
- Preferred fluoride ion sources for use herein include sodium fluoride, potassium fluoride and ammonium fluoride. Sodium fluoride is particularly preferred.
- the instant compositions provide from about 50 ppm to 10,000 ppm, more preferably from about 100 to 3000 ppm, of fluoride ions in the compositions that contact dental surfaces when used with the delivery system of the present invention.
- Anti-microbial agents can also be present in the oral care compositions or substances of the present invention.
- Such agents may include, but are not limited to, 5-chloro-2-(2,4-dichlorophenoxy)phenol, commonly referred to as triclosan, and described in The Merck Index, 11th ed. (1989), pp. 1529 (entry no. 9573) in U.S. Pat. No. 3,506,720, and in European Pat. Application No. 0,251,591 of Beecham Group, PLC, published Jan. 7, 1988; phthalic acid and its salts including, but not limited to those disclosed in U.S. Pat. No. 4,994,262, Feb. 19, 1991, preferably magnesium monopotassium phthalate, chlorhexidine (Merck Index, no.
- alexidine Merck Index, no. 222; hexetidine (Merck Index, no. 4624); sanguinarine (Merck Index, no. 8320); benzalkonium chloride (Merck Index, no. 1066); salicylanilide (Merck Index, no. 8299); domiphen bromide (Merck Index, no. 3411); cetylpyridinium chloride (CPC) (Merck Index, no.
- TPC tetradecylpyridinium chloride
- TDEPC N-tetradecyl-4-ethylpyridinium chloride
- octenidine delmopinol, octapinol, and other piperidino derivatives
- ironistannous ion agents antibiotics such as augmentin, amoxicillin, tetracycline, doxycycline, minocycline, and metronidazole
- analogs and salts of the above essential oils including thymol, geraniol, carvacrol, citral, hinokitiol, eucalyptol, catechol (particularly 4-allyl catechol) and mixtures thereof; methyl salicylate; hydrogen peroxide; metal salts of chlorite and mixtures of all of the above.
- Anti-inflammatory agents can also be present in the oral care compositions or substances of the present invention.
- Such agents may include, but are not limited to, non-steroidal anti-inflammatory agents or NSAIDs such as ketorolac, flurbiprofen, ibuprofen, naproxen, indomethacin, aspirin, ketoprofen, piroxicam and meclofenamic acid.
- NSAIDs such as Ketorolac are claimed in U.S. Pat. No. 5,626,838, issued May 6, 1997.
- Disclosed therein are methods of preventing and, or treating primary and reoccurring squamous cell carcinoma of the oral cavity or oropharynx by topical administration to the oral cavity or oropharynx an effective amount of an NSAID.
- Nutrients may improve the condition of the oral cavity and can be included in the oral care compositions or substances of the present invention.
- Nutrients include minerals, vitamins, oral nutritional supplements, enteral nutritional supplements, and mixtures thereof.
- Minerals that can be included with the compositions of the present invention include calcium, phosphorus, fluoride, zinc, manganese, potassium and mixtures thereof. These minerals are disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., ⁇ 1997, pp. 10-17.
- Vitamins can be included with minerals or used separately. Vitamins include Vitamins C and D, thiamine, riboflavin, calcium pantothenate, niacin, folic acid, nicotinamide, pyridoxine, cyanocobalamin, para-aminobenzoic acid, bioflavonoids, and mixtures thereof. Such vitamins are disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., ⁇ 1997, pp. 3-10.
- Oral nutritional supplements include amino acids, lipotropics, fish oil, and mixtures thereof, as disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., ⁇ 1997, pp. 54-54e.
- Amino acids include, but, are not limited to L-Tryptophan, L-Lysine, Methionine, Threonine, Levocamitine or L- carnitine and mixtures thereof.
- Lipotropics include, but, are not limited to choline, inositol, betaine, linoleic acid, linolenic acid, and mixtures thereof.
- Fish oil contains large amounts of Omega-3 (N-3) Polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid.
- Entenal nutritional supplements include, but, are not limited to protein products, glucose polymers, com oil, safflower oil, medium chain triglycerides as disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., ⁇ 1997, pp. 55-57.
- Other materials that can be used with the present invention include commonly known mouth and throat products. Such products are disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., ⁇ 1997, pp. 520b-527. These products include, but, are not limited to anti-fungal, antibiotic and analgesic agents.
- Antioxidants are generally recognized as useful in compositions such as those of the present invention. Antioxidants are disclosed in texts such as Cadenas and Packer, The Handbook of Antioxidants, ⁇ 1996 by Marcel Dekker. Inc. Antioxidants that may be included in the oral care composition or substance of the present invention include, but are not limited to Vitamin E, ascorbic acid, Uric acid, carotenoids, Vitamin A, flavonoids and polyphenols, herbal antioxidants, melatonin, aminoindoles, lipoic acids and mixtures thereof.
- Histamine-2 (H-2 or H2) receptor antagonist compounds may be used in the oral care composition of the present invention.
- selective H-2 antagonists are compounds that block H-2 receptors, but do not have meaningful activity in blocking histamine-1 (H-1 or H1) receptors.
- Selective H-2 antagonists stimulates the contraction of smooth muscle from various organs, such as the gut and bronchi; this effect can be suppressed by low concentrations of mepyramine—a typical antihistaminic drug.
- the pharmacological receptors involved in these mepyramine-sensitive histamine responses have been assembled as H-1 receptors (Ash, A.S.F. & H.O. Schild, Brit. J. Pharmacol Chemother., Vol. 27 (1966), p.
- Histamine also stimulates the secretion of acid by the stomach (Loew, E.R. & O. Chickering, Proc. Soc. Exp. Biol. Med., Vol. 48 (1941), p. 65), increases the heart rate (Trendelenburg, U., J. Pharmacol., Vol. 130 (1960), p. 450), and inhibits contractions in the rat uterus (Dews, P. B. & J. D. P. Graham, Brit. J. Pharmacol. Chemother., Vol. 1 (1946), p. 278); these actions cannot be antagonized by mepyramine and related drugs.
- the H-2 antagonists useful in the oral care compositions or substances are those that blockade the receptors involved in mepyramine-insensitive, non-H-1 (H-2), histamine responses, and do not blockade the receptors involved in mepyramine-sensitive histamine responses.
- Selective H-2 antagonists are those compounds found to be H-2 antagonists through their performance in classical preclinical screening tests for H-2 antagonist function.
- Selective H-2 antagonists are identified as compounds which can be demonstrated to function as competitive or non-competitive inhibitors of histamine-mediated effects in those screening models specifically dependent upon H-2 receptor function, but to lack significant histamine antagonist activity in those screening models dependent upon H-1 receptor function. Specifically, this includes compounds that would be classified as described by Black, J. W., W. A. M. Duncan, C. J. Durant, C. R. Ganellin & E. M. Parsons, “Definition and Antagonism of Histamine H2-Receptors”, Nature, Vol. 236 (Apr. 21, 1972), pp.
- H-2 antagonists if assessed as described by Black through testing with the guinea pig spontaneously beating right atria in vitro assay and the rat gastric acid secretion in vivo assay, but shown to lack in significant H-1 antagonist activity relative to H-2 antagonist activity, if assessed as described by Black with either the guinea pig ileum contraction in vitro assay or the rat stomach muscle contraction in vivo assay.
- selective H-2 antagonists demonstrate no significant H-1 activity at reasonable dosage levels in the above H-1 assays. Typical reasonable dosage level is the lowest dosage level at which 90% inhibition of histamine, preferably 99% inhibition of histamine, is achieved in the above H-2 assays.
- Selective H-2 antagonists include compounds meeting the above criteria which are disclosed in U.S. Pat. Nos. 5,294,433 and 5,364,616 Singer et al., issued Mar. 15, 1994 and Nov. 15, 1994 respectively and assigned to Procter & Gamble, wherein the selective H-2 antagonist is selected from the group consisting of cimetidine, etintidine, ranitidine, ICIA-5165, tiotidine, ORF-17578, lupitidine, donetidine, famotidine, roxatidine, pifatidine, lamtidine, BL-6548, BMY-25271, zaltidine, nizatidine, mifentidine, BMY-52368 (SKF-94482), BL-6341A, ICI-162846, ramixotidine, Wy-45727, SR-58042, BMY-25405, loxtidine, DA-4634, bisfentidine, sufotidine, ebrotidine, HE-30-
- cimetidine (SKF-92334), N-cyano-N′-methyl-N′′-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine:
- Cimetidine is also disclosed in the Merck Index, 11th edition (1989), p. 354 (entry no. 2279), and Physicians' Desk Reference, 46th edition (1992), p. 2228.
- Related preferred H-2 antagonists include burimamide and metiamide.
- Anti-pain or desensitizing agents can also be present in the oral care compositions or substances of the present invention.
- agents may include, but are not limited to, strontium chloride, potassium nitrate, natural herbs such as gall nut, Asarum, Cubebin, Galanga, scutellaria, Liangmianzhen, Baizhi, etc.
- Antiviral actives useful in the present composition include any know actives that are routinely use to treat viral infections. Such anti-viral actives are disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., ⁇ 1997, pp. 402(a)-407(z), incorporated herein by reference in its entirety. Specific examples include anti-viral actives disclosed in U.S. Pat. No. 5,747,070, issued May 5, 1998 to Satyanarayana Majeti, incorporated herein by reference in its entirety. Said Patent discloses the use of stannous salts to control viruses.
- stannous salts and other anti-viral actives are described in detail in Kirk & Othmer, Encyclopedia of Chemical Technology, Third Edition, Volume 23, Wiley-lnterscience Publishers (1982), pp. 42-71, incorporated herein by reference in its entirety.
- the stannous salts that may be used in the present invention would include organic stannous carboxylates and inorganic stannous halides. While stannous fluoride may be used, it is typically used only in combination with another stannous halide or one or more stannous carboxylates or another therapeutic agent.
- Additional components include, but are not limited to, flavoring agents, sweetening agents, xylitol, opacifiers, coloring agents, surfactants, and chelants such as ethylenediaminetetraacetic acid.
- Suitable flavoring agents include, but are not limited to, oil of peppermint, oil of sassafras, clove bud oil, peppermint, menthol, anethole, thymol, methyl salicylate, eucalyptol, cassia, 1-menthyl acetate, sage, eugenol, parsley oil, oxanone, oil of wintergreen, alpha-irisone, oil of spearmint, marjoram, lemon, orange, banana, propenyl guaethol, innamon, and mixtures thereof.
- Pigments may also added to the compositions herein to more precisely indicate the locations at which the composition has actually been applied, allowing the user to apply the composition more thoroughly or evenly. However, such pigments are not intended to mask stains that may exist on the tooth surfaces.
- the optional release liner may be formed from any material which exhibits less affinity for the oral care substance than the oral care substance exhibits for itself and for the backing strip.
- the release liner preferably comprises a rigid sheet of material such as polyethylene, paper, polyester, or other material which is then coated with a non-stick type material.
- the release liner material may be coated with wax, silicone, teflon, fluoropolymers, or other non-stick type materials.
- a preferred release liner is Scotchpak®, produced by 3M.
- the release liner may be cut to substantially the same size and shape as the backing strip or the release liner may be cut larger than the backing strip to provide a readily accessible means for separating the material from the backing strip.
- the release liner may be formed from a brittle material which cracks when the backing strip is flexed or from multiple pieces of material or a scored piece of material. Alternatively, the release liner may be in two overlapping pieces such as a typical adhesive strip bandage design. A further description of materials suitable as release agents is found in Kirk-Othmer Encyclopedia of Chemical Technology, Fourth Edition, Volume 21, pp. 207-218, incorporated herein by reference.
- One example of a preferred backing strip is a 0.013 mm thick piece of polyethylene film.
- the backing strip may be provided with an array of shallow pockets, typically 0.4 mm across and 0.1 mm deep.
- the backing strip has a flexural stiffness of about 0.6 grams/centimeter as measured on a Handle-O-Meter, model #211-300, available from Thwing-Albert Instrument Co. of Philadelphia, Pa., as per test method ASTM D2923-95.
- a preferred backing strip is a 0.3 mm thick piece of substantially water soluble material such as rice paper.
- Another example of a preferred backing strip is a 0.3 mm thick piece of pullulan paper.
- compositions of Tables 1 and 2 are non-aqueous.
- the oral care substances are dispersed or dissolved in a solution comprising the organosiloxane resin, the fluid diorganopolysiloxane polymer, the carrier, and the rheology modifier.
- the hydrophobic compositions of Tables 1 and 2 are suitably prepared as follows. Three hundred (300) grams of organosiloxane resin solution (for example, 43.7% MQ resin in isododecane, or in a 50/50 mixture of ethyl acetate and butanone, or in a mixture of ethyl acetate, propyl acetate and HFE) are mixed with 147.30 grams of fluid diorganopolysiloxane polymer solution (for example, 50% SE30 silicone gum in isododecane or, a 50/50 mixture of ethyl acetate and butanone, or a mixture of ethyl acetate, propyl acetate, and HFE.). The oral care substances are then dispersed in the resin/gum mixture. This method may be carried out without the presence of the silicone gum.
- organosiloxane resin solution for example, 43.7% MQ resin in isododecane, or in a 50
- compositions of Table 3 may be prepared as above, except that a carrier is not added, and the surfactant and flavorant are added after the resin and silicone gum have been mixed until completely dissolved.
- compositions of Tables 4-7 are suitably prepared as follows. Add the solvents into a container suitable to minimize solvent loss. Add the rheology modifiers and mix until well dispersed. Add the silicone resin and mix until completely dissolved. Add the silicone gum and/or silicone fluids and mix until completely dissolved. At this time add any salts such as sodium percarbonate and/or other oral care actives, aesthetic ingredients such as opacifiers, sweeteners, dyes, and flavors. Continue mixing until homogeneous. Additional high shear mixing may be used to promote the mixing. Pack into airtight containers.
- premixes of the silicone resin and/or the silicone gum may be prepared prior to incorporation into the final blending step to facilitate silicone dissolution and ease of manufacturing.
- the order of ingredient addition may also vary such as the addition of the rheology modifier(s) may be moved to a later step allowing lower viscosity to be maintained until the later stages of the blending step.
- composition After making the composition according to the any of the methods described above, cast the composition onto a piece of backing strip material (rice paper, for example). Then dry it for about 10-60 minutes to allow some of the volatile component of the carrier, if present, to volatize. A adhesive film will form on the backing strip material. The thickness of adhesive film can be controlled by the amount of the composition used when the composition is cast onto the backing strip. Then cut the backing strip into the desired shape and size.
- a piece of backing strip material rice paper, for example.
- a backing strip is applied to the desired oral surface by the wearer.
- the side of the strip facing the oral surface is coated with an oral care composition that is preferably in a highly viscous state.
- the backing strip readily conforms to the oral care surface during application by lightly pressing it there against.
- the backing strip can be left in oral cavity if it is substantially water soluble or can be peeled off if it is substantially water insoluble. After the strip has dissolved in-situ or has been peeled away by the user, the oral care composition remains on the oral surfaces as a thin a film.
- the user need only apply a backing strip that has been coated with composition herein that contains the oral care substance or substances necessary in order to obtain a desired effect, e.g., whitening, breath freshening, caries prevention, pain relief, gum health, tartar control, etc. to the tooth surfaces in the areas desired.
- compositions may also be applied to other surfaces of the oral cavity, such as the gingival or mucosal tissues, or to any other oral cavity surface.
- Prolonged delivery of the oral care substance is made possible as the oral care substance is released from the film over time. Then, any residual oral care substance may be easily removed by wiping, brushing or rinsing the oral surface after a desired period of time has elapsed, or in the normal course of tooth brushing or other oral care activities.
- the film will last from about 2 hours to 8 hours regardless of the reactivity of the oral care substance.
- the compositions are almost unnoticeable when applied to the oral cavity.
- the user may or may not choose to brush the teeth or rinse the mouth before using the system.
- the surfaces of the oral cavity are neither required to be rigorously dried nor to be excessively wet with saliva or water before the system is used. However, it is believed that adhesion to the tooth enamel surfaces will be improved if the teeth are dry when the system is applied.
- the present invention relates not only to methods for delivering an oral care substance to the oral cavity of a human, but also to methods of delivering an oral care substance to the oral cavity of an animal, e.g., household pets or other domestic animals, or animals kept in captivity.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Biomedical Technology (AREA)
- Dentistry (AREA)
- Physiology (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
Disclosed is a delivery system for delivering an oral care substance to the oral cavity, the delivery system comprising: (a) a removable backing strip having sufficient flexibility so as to be readily conformable to an oral surface when the delivery system is placed thereagainst; and (b) an oral care composition applied to the strip of material such that when the delivery system is placed on the oral surface the oral care composition contacts the oral surface, the oral care composition comprising: (i) an organosiloxane resin; (ii) a theology modifier; and (iii) at least one oral care substance; wherein the oral care composition remains on the oral surface after the backing strip is removed. Further disclosed are such delivery systems in which the oral care composition further comprises fluid diorganopolysiloxane-based polymers; such compositions may further comprise carriers for solubilizing the organosiloxane resin and the fluid diorganopolysiloxane-based polymers. Still further disclosed are methods of using the delivery systems.
Description
This application is a reissue of application Ser. No. 10/019,032, filed Mar. 20, 2002, now U.S. Pat. No. 6,649,147 which was the National Stage of International Application No. PCT/US00/18188 filed Jun. 30, 2000 and which was a continuation-in-part of International Application No. PCT/US/00/15890 filed Jun. 9, 2000; a continuation-in-part of International Application No. PCT/US00/15891 filed Jun. 9, 2000; a continuation-in-part of International Application No. PCT/US99/15130 filed Jul. 2, 1999; and a continuation-in-part of International Application No. PCT/US99/15131 filed Jul. 2, 1999.
The present invention relates to a delivery system for applying and delivering an oral care substance or composition to oral surfaces including the tooth enamel. The composition forms a film on the surface to which it has been applied and provides sustained release of the oral care substance from the film for prolonged therapeutic, prophylactic, and/or cosmetic benefits. More specifically, the present invention relates to systems comprising a removable backing strip to facilitate the application of compositions comprising organosiloxane resins for delivering oral care substances to the tooth enamel. In addition, it is believed that the compositions herein may further provide sustained release benefits to other oral surfaces, such as the gingival and mucosal tissues, as well as to the surfaces of the teeth.
Oral care products by which various oral care substances or actives can be delivered to the soft and hard tissues of the oral cavity have previously been known. Examples of such oral care products include, for example, brushing aids such as dentifrice products for delivery of anti-caries actives such as fluoride or other actives for the reduction of the bacteria that lead to the formation of plaque, and mouthwashes containing breath freshening actives and/or anti-bacterial actives. In addition, bleaching agents such as peroxide that can be applied directly to the surfaces of the teeth, i.e., to the tooth enamel, have been developed.
However, it has been found that such conventional product forms typically do not provide substantivity sufficient to maintain actives on the hard and soft oral tissues for a period of time sufficient to enhance or prolong the therapeutic, prophylactic, and/or cosmetic benefits provided by the actives. Neither have such conventional product forms been able to provide sustained delivery of oral care actives, without periodic reapplication at relatively short time intervals, or without a special delivery device or containment means such as a mouthpiece.
One such system is disclosed in International Publication No. WO 98/55709 WO 98/55079, “A Delivery System for an Oral Care Substance Using a Strip of Material Having a Low Flexural Stiffness,“ published on Dec. 10, 1998. This system involves the combination of an oral care substance that directly contacts the oral cavity surfaces, and a flexible strip of material that is worn over the oral care substance, to protect the substance from erosion and from contact with other oral surfaces and, or saliva. In this system, the strip is worn in order to hold the composition in place for a sufficient amount of time to allow the active to act upon the oral surface.
Other attempts have previously been made to enhance the substantivity of whitening bleaches, bactericides, and other active components of oral care products. See, e.g., U.S. Pat. No. 5,425,953 to Sintov el al. on Jun. 20, 1995, in which a film forming, water-soluble cellulosic polymer is used to deliver a bleaching agent to the teeth; U.S. Pat. No. 5,438,076 to Friedman et al., in which liquid methacrylate acid copolymer compositions are used to deliver a bacteriocidal pharmacological agent; and International Patent Appln. No. PCT/CN97/00 to Huang, published on Jul. 24, 1997, disclosing a film-coating composition comprising cellulose and polyvinyl acetal, coumarone-indene resin, or shellac as a film former to deliver bleaches to the tooth enamel.
However, the above systems are water-soluble, i.e., they are readily dissolved by saliva, generally within about 1-3 hours after application. Therefore, their degree of durability is low, and they cannot provide long-term delivery of the active ingredient that is present in the composition. In addition, their water-soluble nature precludes them from being used with oral care actives that would be unstable in water-based films. Sodium percarbonate is one example of such an active; it would be unstable in the high pH environment of an aqueous-based film.
In order to provide an applied composition with a relatively higher degree of durability, the use of protective coatings that are applied to the teeth has been described. See, U.S. Pat. No. 5,401,528, to Schmidt on Mar. 18, 1995, in which organically modified silicic acid polycondensates are deposited on the teeth, then polymerized in-situ by curing, to coat the teeth in order to protect them from plaque deposits. This system is not a true delivery system by which an active ingredient is released over time; instead, it provides a barrier by which the deleterious effect of plaque-causing bacteria may be diminished.
Although such a barrier coating may offer a benefit in terms of enhanced durability, it requires the use of special equipment and complex application; thus, it cannot be performed at home and cannot be used for self-treatment.
Therefore, it can be seen that none of these previous developments can offer the combination of both long-term delivery of an oral care substance or active ingredient and the convenience of easy application, discreet self-treatment, and home use. Based on the foregoing, there is a need for a convenient delivery system for various oral care substances which is easy to apply and in which the substantivity of the active ingredients is enhanced. None of the existing art provides all of the advantages and benefits of the present invention.
The present invention is directed to a delivery system for delivering an oral care substance to the oral cavity, the delivery system comprising: (a) a removable backing strip having sufficient flexibility so as to be readily conformable to an oral surface when the delivery system is placed thereagainst; and (b) an oral care composition applied to the strip of material such that when the delivery system is placed on the oral surface the oral care composition contacts the oral surface, the oral care composition comprising: (i) an organosiloxane resin; (ii) a rheology modifier; and (iii) at least one oral care substance; wherein the oral care composition remains on the oral surface after the backing strip is removed.
The present invention is also directed to such systems in which the oral care composition further comprises fluid diorganopblysiloxane-based polymers. Such compositions may further comprise carriers for solubilizing the organosiloxane resin and the fluid diorganopolysiloxane-based polymers.
The present invention is still further directed to methods of using the delivery systems herein.
These and other features, aspects, and advantages of the invention will become evident to those skilled in the art from a reading of the present disclosure.
While the specification concludes with claims particularly pointing out and distinctly claiming the present invention, it is believed that the present invention will be better understood from the following description of preferred embodiments, taken in conjunction with the accompanying drawings, in which like reference numerals identify identical elements and wherein:
All percentages and ratios used hereinafter are by weight of total composition, unless otherwise indicated.
All measurements referred to herein are made at 25° C. unless otherwise specified.
The abbreviation “cm”, as used herein, means centimeter. The abbreviation “mm” as used herein, means millimeter.
All percentages, ratios, and levels of ingredients referred to herein are based on the actual amount of the ingredient, and do not include solvents, fillers, or other materials with which the ingredient may be combined as a commercially available product, unless otherwise indicated.
All publications, patent applications, and issued patents mentioned herein are hereby incorporated in their entirety by reference. Citation of any reference is not an admission regarding any determination as to its availability as prior art to the claimed invention.
Herein, “comprising” means that other steps and other components which do not affect the end result can be added. This term encompasses the terms “consisting of” and “consisting essentially of.”
Referring now to the drawings, and more particularly to FIGS. 1 and 2 , there is shown a first preferred embodiment of the present invention, generally indicated as 10, representing a delivery system for applying and delivering an oral care composition to an oral surface. Delivery system 10 has a backing strip of material 12, which is initially substantially flat.
Applied or coated onto the backing strip 12 is an oral care composition 14, as described herein. Preferably, the oral care composition 14 is homogeneous, uniformly and continuously coated onto the backing strip 12, as shown in FIG. 3. However, oral care composition 14 may alternatively be a laminate or separated layers of components, an amorphous mixture of components, separate stripes or spots or other patterns of different components, or a combination of these structures including a continuous coating of oral care composition 14 along a longitudinal axis of a portion of the backing strip 12.
As shown in FIG. 4 , an alternative embodiment, a backing strip 12 may have shallow pockets 18 formed therein. When oral care composition 14 is coated on a composition-coated side of backing strip 12, additional oral care composition 14 fills shallow pockets 18 to provide reservoirs of additional oral care composition 14.
In both FIGS. 5 and 6 , delivery system 24 represents a backing strip 12 and an oral care composition 14, with oral care composition 14 on the side of the backing strip 12 the is facing tooth 22. Oral care composition 14 may be pre-applied to the backing strip 12, or may be applied to the backing strip 12 by the delivery system user. In either case, the backing strip 12 has a thickness and flexural stiffness which enable it to conform to the contoured surfaces of tooth 22 and to adjacent soft tissue 20 during application of the oral care composition 14. The backing strip has sufficient flexibility to form to the contours of the oral surface, in this figure the surface being a plurality of adjacent teeth. The backing strip is also readily conformable to tooth surfaces and to the interstitial tooth spaces without permanent deformation during application.
The backing strip of material serves to carry the oral care compositions herein, and facilitates the application of the oral compositions to the oral surfaces. In preferred embodiments of the present invention, the backing strip is removable, i.e., it need not be worn in the oral cavity for the duration of the time that the oral care composition is present in the oral cavity. As used herein, the term “removable” is intended to include manual removal of the backing strip, e.g., by peeling, as well as removal of the backing strip as a result of in-situ dissolution in the oral cavity, i.e., that occurs without the need for manual peeling.
The backing strip of material may comprise polymers, natural and synthetic woven materials, non-woven material, foil, paper, rubber, and combinations thereof. The backing strip may be a single layer of material or a laminate comprised of more than one layer. Regardless of the number of layers, the backing strip is either substantially water soluble (dissolves in-situ) or substantially water insoluble.
In the case of a substantially water insoluble backing strip, the strip may be removed by peeling immediately after application, see FIG. 11 , leaving the active materials adhering to the teeth and/or other oral surfaces, or removed after some time interval. Preferably, the material is any type of polymer or combination of polymers that meet the required flexural rigidity and is compatible with oral care substances. Suitable polymers include, but are not limited to, polyethylene, ethylvinylacetate, polyesters, ethylvinyl alcohol, pullulan film, combinations thereof. Examples of polyesters include Mylar® and fluoroplastics such as Teflon®, both manufactured by DuPont. The preferable material is polyethylene. The backing strip is generally less than about 1 mm thick, preferably less than about 0.05 mm thick, and more preferably from about 0.001 to about 0.03 mm thick. A polyethylene backing strip is preferably less than about 0.1 mm thick and more preferably from about 0.005 to about 0.02 mm thick.
The backing strip may also be comprised of a substantially water and/or saliva soluble material such as agar film, starch paper, rice paper, natural gum, pullulan paper, or mixtures thereof. Such embodiments are very convenient for consumer use as they do not require the step of peeling the backing strip away. They may also provide added safety during overnight use, because there is no chance of accidentally swallowing a backing strip that becomes loose during sleeping.
The shape of the backing strip is any shape and size that covers the desired oral surface. The width of the backing strip will also depend upon the oral surface area to be covered. In one example, the width of the strip is from about 0.5 cm to about 4 cm and preferably from about 1 cm to about 2 cm.
The backing strip may contain shallow pockets. When the oral care substance is coated on a such a backing strip, additional oral care substance fills shallow pockets to provide reservoirs of additional oral care substance. Additionally, the shallow pockets help to provide texture to the delivery system. The film will preferably have an array of shallow pockets. Generally, the shallow pockets are approximately 0.4 mm across and 0.1 mm deep. When shallow pockets are included in the backing strip and oral care substances are applied to it in various thicknesses, the overall thickness of the delivery system is generally less than about 1 mm. Preferably, the overall thickness is less than about 0.5 mm.
The amount of oral care composition applied to the strip of material or oral surface depends upon the size and capacity of the piece of material, concentration of the active, and the desired benefit sought. Generally, less than about 1 gram of oral care substance is required. Preferably, from about 0.05 grams to about 0.5 grams and more preferably from about 0.1 gram to about 0.4 grams of the oral care substance is used. The amount of oral care substance per square cm of material is less than about 0.2 grams/cm2, preferably from about 0.005 to about 0.1 grams/cm2, and more preferably from about 0.01 grams/cm2 to about 0.04 grams/cm2.
The oral care composition of the present invention can be in the form of a viscous liquid, paste, gel, solution, or other suitable form that can provide sufficient adhesion. Preferably, the oral care composition is in the form of an adhesive film. The oral care substance will have a viscosity of from about 200 to about 1,000,000 cps at low shear rates (less than one 1/seconds). Preferably, the viscosity is from about 100,000 to about 800,000 cps and more preferably from about 400,000 to about 600,000 cps.
One preferred embodiment of the oral composition herein is comprised of an organosiloxane resin; a rheology modifier; and at least one oral care substance.
Another preferred embodiment of the composition is comprised of an organosiloxane resin; a fluid diorganopolysiloxane-based polymer; a rheology modifier; and at least one oral care substance. Another preferred embodiment of such an oral care composition further comprises a carrier capable of solubilizing the organosiloxane resin and the fluid diorganopolysiloxane-based polymer. These components are described in greater detail below.
Silicone resins are highly crosslinked polymeric siloxane systems. The crosslinking is introduced through the incorporation of tri-functional and tetra-functional silanes with mono-functional or di-functional, or both, silanes during manufacture of the silicone resin. As is well understood in the art, the degree of crosslinking that is required in order to result in a silicone resin will vary according to the specific silane units incorporated into the silicone resin. In general, silicone materials which have a sufficient level of trifunctional and tetrafunctional siloxane monomer units, and hence, a sufficient level of crosslinking, such that they dry down to a rigid, or hard, film are considered to be silicone resins. The ratio of oxygen atoms to silicon atoms is indicative of the level of crosslinking in a particular silicone material. Silicone materials which have at least about 1.1 oxygen atoms per silicon atom will generally be silicone resins herein. Preferably, the ratio of oxygen:silicon atoms is at least about 1.2:1.0.
Silicone materials and silicone resins in particular can conveniently be identified according to a shorthand nomenclature system well known to those skilled in the art as the “MDTQ” nomenclature. Under this system, the silicone is described according to the presence of various siloxane monomer units which make up the silicone. Briefly, the symbol M denotes the mono-functional unit (CH3)3SiO)0.5; D denotes the difunctional unit (CH3)2SiO; T denotes the trifunctional unit (CH3)SiO1.5; and Q denotes the quadra- or tetra-functional unit SiO2. Note that a small amount, up to about 5% of silanol or alkoxy functionality may also be present in the resin structure as a result of processing.
Primes of the unit symbols, e.g., M′, D′, T′, and Q′, denote substituents other than methyl, and must be specifically defined for each occurrence. Typical alternate substituents include groups such as vinyl, phenyl, amino, hydroxyl, etc. The molar ratios of the various units, either in terms of subscripts to the symbols indicating the total number of each type of unit in the silicone, or an average thereof, or as specifically indicated ratios in combination with molecular weight, complete the description of the silicone material under the MDTQ system. Higher relative molar amounts of T, Q, T′ and/or Q′ to D, D′, M and/or M′ in a silicone resin is indicative of higher levels of crosslinking. As discussed before, however, the overall level of crosslinking can also be indicated by the oxygen to silicon ratio.
The organosiloxane resins are solid at about 25° C. and the average molecular weight of the resins is from about 1,000 to about 10,000. The resins are soluble in organic solvents such as toluene, xylene, isoparaffins, and cyclosiloxanes or the volatile carrier described below, indicating that the resin is not sufficiently crosslinked such that the resin is insoluble in the volatile carrier.
The silicone resins preferred for use herein are MQ, MT, MTQ, and MDTQ resins; such MQ resins are disclosed in U.S. Pat. No. 5,330,747, Krzysik, issued Jul. 19, 1994. Thus, the preferred silicone substituent is methyl. Especially preferred are MQ resins wherein the M:Q ratio is from about 0.5:1.0 to about 1.5:1.0. Organosiloxane resins such as these are commercially available, for example, Wacker 803 and 804 available from Wacker Silicones Corporation of Adrian, Mich., US, and G.E. 1170-002 from the General Electric Company.
The level of the resin that is used in the compositions is dependent on its degree of solubility in the formulation, particularly in the solvents used. Generally, the range of resin used in the present invention is from about 5% to about 70%, preferably from about 15% to about 45%, and even more preferably from about 20% to about 40%.
In addition to the organosiloxane resins disclosed above, the compositions of the present invention may further comprise a fluid diorganopolysiloxane-based polymer to be combined with the organosiloxane resins. Said fluid diorganopolysiloxane-based polymers useful in the present invention span a large range of viscosities; from about 10 to about 10,000,000 centistokes (cSt) at 25° C. Some diorganopolysiloxane polymers useful in this invention exhibit viscosities greater than 10,000,000 centistokes (cSt) at 25° C. and therefore are characterized by manufacturer specific penetration testing. Examples of this characterization are GE silicone materials SE 30 and SE 63 with penetration specifications of 500-1500 and 250-600 (tenths of a millimeter) respectively.
Among the fluid diorganopolysiloxane-based polymers of the present invention are diorganopolysiloxane polymers comprising repeating units, where said units correspond to the formula (R2SiO)n, where R is a monovalent hydrocarbon radical containing from 1 to 6 carbon atoms, preferably selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, amyl, hexyl, vinyl, allyl, cyclohexyl, amino alkyl, phenyl, fluoroalkyl and mixtures thereof. The fluid diorganopoylsiloxane polymers employed in the present invention may contain one or more of these hydrocarbon radicals as substituents on the siloxane polymer backbone. The fluid diorganopolysiloxane polymers may be terminated by triorganosilyl groups of the formula (R′3Si) where R′ is a radical selected from the group consisting of monovalent hydrocarbons containing from 1-6 carbon atoms, hydroxyl groups, alkoxyl groups and mixtures thereof. The fluid diorganopolysiloxane polymer must be compatible in solution with the organosiloxane resin and the volatile carrier. The term “compatible” refers to the formation of a single phase solution when the fluid diorganopolysiloxane polymer, the organosiloxane resin and the volatile carrier are mixed together in ratios required for a specific formulation. For example, the lower viscosity fluid diorganopolysiloxane polymers (viscosity of about 10 to 100cSt.) are particularly useful when using ethanol as the principal volatile carrier. For higher viscosity polymers, e.g., poly (dimethylsiloxane), herein referred to as PDMS or silicone gum, having a viscosity of at least 100,000 cSt, volatile carriers other than ethanol are preferred.
-
- where R is a methyl group.
Fluid diorganopolysiloxane polymers such as these are commercially available, for example, SE 30 silicone gum and SF96 silicone fluid available from the General Electric Company. Similar materials can also be obtained from Dow Coming and from Wacker Silicones.
Another fluid diorganosiloxane-based polymer preferred for use in the present invention is a dimethicone copolyol to modify film forming characteristics as desired. The dimethicone copolyol can be further characterized as polyalkylene oxide modified polydimethysiloxanes, such as manufactured by the Witco Corporation under the trade name Silwet. Similar materials can be obtained from Dow Coming, Wacker Silicones and Goldschmidt Chemical Corporation as well as other silicone manufacturers.
In preferred embodiments of the present invention, the ratio of organosiloxane resin to fluid diorganopolysiloxane polymer is preferably from about 10:1 to about 1:10, more preferably from about 2:1 to about 8:1, and still more preferably from about 4:1 to 6:1.
The compositions further comprise a rheology modifier which inhibits settling and separation of components or controls settling in a manner which facilitates re-dispersion and may control rheological flow properties for strip making. Suitable rheology modifiers herein include organo modified clays, silicas, polyethylene, and mixtures thereof. The preferred organophilic clays comprise quatemium-18 hectorite or Stearalkonium hectorite, such as Bentone 27 and 38™ from Rheox, organoclay dispersion such as Bentone ISD gel™; or bentonite organo modified clays such as Bentone 34 ™ from Rheox or the Claytone Series™ from Southern Clay Products; and mixtures thereof. The preferred silicas may be fumed silica such as the Aerosil™ series from Degussa or the Cab-o-sil™ series from Cabot Corporation, silica gels such as the Sylodent ™ or Sylox™ series from W. R. Grace & Co. or precipitated silica such as Zeothix 265 from J. M. Huber Corporation.
The rheology modifier is preferably present in the composition at a level of from about 0.1% to about 30%, preferably from about 0.5% to about 10%, and even more preferably about 1% to about 3% of the composition.
The oral care compositions that comprise a fluid diorganosiloxane-based polymer may further comprise a carrier. The carrier may be used to solubilize the organosiloxane resin and the fluid diorganosiloxane-based polymer. If present, the carrier is preferably comprised of a volatile component and a non-volatile component. During preparation of a delivery system in which the oral care composition comprises such a carrier, after the composition has been cast onto the backing strip, the volatile component will volatize and the non-volatile component will remain in the composition to provide softness and flexiblity to the backing strip.
The carrier comprises from about 0% to about 90%, preferably from about 0% to about 80%, and more preferably from about 0% to about 70%, of the composition. The carrier of the present invention is selected from the group consisting of hydrocarbon oils, volatile silicones, non-hydrocarbon solvents, and mixtures thereof.
Hydrocarbon oils useful in the present invention include those having boiling points in the range of 60-260° C., more preferably hydrocarbon oils having from about C8 to about C20 chain lengths, most preferably C8 to C20 isoparaffins. Of these isoparaffins most preferred are selected from the group consisting of isododecane, isohexadecane, isoeocosane, 2,2,4-trimethylpentane, 2,3-dimethylhexane and mixtures thereof. Most preferred is isododecane, available as, for example, Pernethyl 99A from Permethyl Corporation corresponding to the formula:
CH3(CH2)10CH3
CH3(CH2)10CH3
Preferred volatile silicone fluids include cyclomethicones having 3, 4 and 5 membered ring structures corresponding to the formula:
-
- where X is from about 3 to about 6. Such volatile silicones include 244 Fluid, 344 Fluid and 245 Fluid, and 345 Fluid all from Dow Corning Corporation.
The general classes of non-hydrocarbon solvents useful herein include esters, ketones, alcohols, fluorocarbons and fluorocarbon ethers having boiling points in the range of 60 to 200° C. Non-hydrocarbon solvents or mixtures thereof particularly useful include those that are capable of-solubilizing the resin and/or the diorganopolysiloxane-based polymer. Such solvents include but are not limited to ethanol, acetone, butanone, ethyl acetate, propyl acetate, amyl acetate, ethyl butyrate, methyl nonafluoroisobutyl ether, methyl nonafluorobutyl ether, and mixtures thereof. These non-hydrocarbon solvents are readily available such as ethyl acetate and methyl ethyl ketone, both supplied by J. T. Baker of Phillispburg, N.J, and HFE (a mixture of methyl nonafluoroisobutyl ether and methyl nonafluorobutyl ether), supplied by the 3M Company.
The oral care substance preferably contains an active at a level where upon directed use, the benefit sought by the wearer is promoted without detriment to the oral surface to which it is applied. Examples of the oral conditions these actives address include, but, are not limited to, appearance and structural changes to teeth, whitening, stain bleaching, stain removal, plaque removal, tartar removal, cavity prevention and treatment, inflamed and/or bleeding gums, mucosal wounds, lesions, ulcers, aphthous ulcers, cold sores, tooth abscesses, and the elimination of mouth malodor resulting from the conditions above and other causes such as microbial proliferation.
Suitable oral care substances include any material that is generally considered safe for use in the oral cavity and that provides changes to the overall appearance and/or health of the oral cavity. The level of oral care substance in the compositions of the present invention is generally, unless specifically noted, from about 0.01% to about 50%, preferably from about 0.1% to about 20%, more preferably from about 0.5% to about 10%, and even more preferably from about 1% to about 7%, by weight of the composition.
Oral care compositions or substances of the present invention may include many of the actives previously disclosed in the art. The following is a non-limiting list of oral care actives that may be used in the present invention.
1. Teeth Whitening Actives
Teeth whitening actives may be included in the oral care substance of the present invention. The actives suitable for whitening are selected from the group consisting of the peroxides, metal chlorites, perborates, percarbonates, peroxyacids, persulfates, and combinations thereof. Suitable peroxide compounds include hydrogen peroxide, urea peroxide, calcium peroxide, carbamide peroxide, and mixtures thereof. Most preferred is carbamide peroxide. Suitable metal chlorites include calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, and potassium chlorite. Additional whitening actives may be hypochlorite and chlorine dioxide. The preferred chlorite is sodium chlorite. A preferred percarbonate is sodium percarbonate. Preferred persulfates are oxones.
2. Anti-tartar Agents
Anti-tartar agents known for use in dental care products include phosphates. Phosphates include pyrophosphates, polyphosphates, polyphosphonates and mixtures thereof. Pyrophosphates are among the best known for use in dental care products. Pyrophosphate and polyphosphate ions are delivered to the teeth derive from pyrophosphate polyphosphate salts. The pyrophosphate salts useful in the present compositions include the dialkali metal pyrophosphate salts, tetra-alkali metal pyrophosphate salts, and mixtures thereof. Disodium dihydrogen pyrophosphate (Na2H2P2O7), tetrasodium pyrophosphate (Na4P2O7), and tetrapotassium pyrophosphate (K4P2O7) in their unhydrated as well as hydrated forms are the preferred species. While any of the above mentioned pyrophosphate salts may be used, tetrasodium pyrophosphate salt is preferred. Sodium polyphosphate and triethanolamine polyphosphates, for example, are preferred.
The pyrophosphate salts are described in more detail in Kirk & Othmer, Encyclopedia of Chemical Technology, Third Edition, Volume 17, Wiley-lnterscience Publishers (1982). Additional anticalculus agents include pyrophosphates or polyphosphates disclosed in U.S. Pat. No. 4,590,066 issued to Parran & Sakkab on May 20, 1986; polyacrylates and other polycarboxylates such as those disclosed in U.S. Pat. No. 3,429,963 issued to Shedlovsky on Feb. 25, 1969 and U.S. Pat. No. 4,304,766 issued to Chang on Dec. 8, 1981; and U.S. Pat. No. 4,661,341 issued to Benedict & Sunberg on Apr. 28, 1987; polyepoxysuccinates such as those disclosed in U.S. Pat. No. 4,846,650 issued to Benedict, Bush & Sunberg on Jul. 11, 1989; ethylenediaminetetraacetic acid as disclosed in British Pat. No. 490,384 dated Feb. 15, 1937; nitrilotriacetic acid and related compounds as disclosed in U.S. Pat. No. 3,678,154 issued to Widder & Briner on Jul. 18, 1972; polyphosphonates as disclosed in U.S. Pat. No. 3,737,533 issued to Francis on Jun. 5, 1973, U.S. Pat. No. 3,988,443 issued to Ploger, Schmidt-Dunker & Gloxhuber on Oct. 26, 1976 and U.S. Pat. No. 4,877,603 issued to Degenhardt & Kozikowski on Oct. 31, 1989. Anticalculus phosphates include potassium and sodium pyrophosphates; sodium tripolyphosphate; diphosphonates, such as ethane-1-hydroxy-1,1-diphosphonate, 1-azacycloheptane-1,1-diphosphonate, and linear alkyl diphosphonates; linear carboxylic acids; and sodium zinc citrate.
Agents that may be used in place of or in combination with the pyrophosphate salt include such known materials as synthetic anionic polymers including polyacrylates and copolymers of maleic anhydride or acid and methyl vinyl ether (e.g., Gantrez), as described, for example, in U.S. Pat. No. 4,627,977, to Gaffar et al.; as well as, e.g., polyamino propoane sulfonic acid (AMPS), zinc citrate trihydrate, polyphosphates (e.g., tnpolyphosphate; hexametaphosphate), diphosphonates (e.g., EHDP; AHP), polypeptides (such as polyaspartic and polyglutamic acids), and mixtures thereof.
3. Fluoride Ion Source
Fluoride ion sources are well known for use in oral care compositions as anticaries agents. Fluoride ions are contained in a number of oral care compositions for this purpose, particularly toothpastes. Patents disclosing such toothpastes include U.S. Pat. No. 3,538,230, Nov. 3, 1970 to Pader et al; U.S. Pat. No. 3,689,637, Sep. 5, 1972 to Pader; U.S. Pat. No. 3,711,604, Jan 16, 1973 to Colodney et al; U.S. Pat. No. 3,911,104, Oct. 7, 1975 to Harrison; U.S. Pat. No. 3,935,306, Jan. 27, 1976 to Roberts et al; and U.S. Pat. No. 4,040,858, Aug. 9, 1977 to Wason.
Application of fluoride ions to dental enamel serves to protect teeth against decay. A wide variety of fluoride ion-yielding materials can be employed as sources of soluble fluoride in the instant compositions. Examples of suitable fluoride ion-yielding materials are found in Briner et al; U.S. Pat. No. 3,535,421; issued Oct. 20, 1970 and Widder et al; U.S. Pat. No. 3,678,154; issued Jul. 18, 1972. Preferred fluoride ion sources for use herein include sodium fluoride, potassium fluoride and ammonium fluoride. Sodium fluoride is particularly preferred. Preferably the instant compositions provide from about 50 ppm to 10,000 ppm, more preferably from about 100 to 3000 ppm, of fluoride ions in the compositions that contact dental surfaces when used with the delivery system of the present invention.
4. Anti-microbial Agents
Anti-microbial agents can also be present in the oral care compositions or substances of the present invention. Such agents may include, but are not limited to, 5-chloro-2-(2,4-dichlorophenoxy)phenol, commonly referred to as triclosan, and described in The Merck Index, 11th ed. (1989), pp. 1529 (entry no. 9573) in U.S. Pat. No. 3,506,720, and in European Pat. Application No. 0,251,591 of Beecham Group, PLC, published Jan. 7, 1988; phthalic acid and its salts including, but not limited to those disclosed in U.S. Pat. No. 4,994,262, Feb. 19, 1991, preferably magnesium monopotassium phthalate, chlorhexidine (Merck Index, no. 2090), alexidine (Merck Index, no. 222; hexetidine (Merck Index, no. 4624); sanguinarine (Merck Index, no. 8320); benzalkonium chloride (Merck Index, no. 1066); salicylanilide (Merck Index, no. 8299); domiphen bromide (Merck Index, no. 3411); cetylpyridinium chloride (CPC) (Merck Index, no. 2024; tetradecylpyridinium chloride (TPC); N-tetradecyl-4-ethylpyridinium chloride (TDEPC); octenidine; delmopinol, octapinol, and other piperidino derivatives; nicin preparations; zincistannous ion agents; antibiotics such as augmentin, amoxicillin, tetracycline, doxycycline, minocycline, and metronidazole; and analogs and salts of the above; essential oils including thymol, geraniol, carvacrol, citral, hinokitiol, eucalyptol, catechol (particularly 4-allyl catechol) and mixtures thereof; methyl salicylate; hydrogen peroxide; metal salts of chlorite and mixtures of all of the above.
5. Anti-inflammatory Agents
Anti-inflammatory agents can also be present in the oral care compositions or substances of the present invention. Such agents may include, but are not limited to, non-steroidal anti-inflammatory agents or NSAIDs such as ketorolac, flurbiprofen, ibuprofen, naproxen, indomethacin, aspirin, ketoprofen, piroxicam and meclofenamic acid. Use of NSAIDs such as Ketorolac are claimed in U.S. Pat. No. 5,626,838, issued May 6, 1997. Disclosed therein are methods of preventing and, or treating primary and reoccurring squamous cell carcinoma of the oral cavity or oropharynx by topical administration to the oral cavity or oropharynx an effective amount of an NSAID.
6. Nutrients
Nutrients may improve the condition of the oral cavity and can be included in the oral care compositions or substances of the present invention. Nutrients include minerals, vitamins, oral nutritional supplements, enteral nutritional supplements, and mixtures thereof.
Minerals that can be included with the compositions of the present invention include calcium, phosphorus, fluoride, zinc, manganese, potassium and mixtures thereof. These minerals are disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., © 1997, pp. 10-17.
Vitamins can be included with minerals or used separately. Vitamins include Vitamins C and D, thiamine, riboflavin, calcium pantothenate, niacin, folic acid, nicotinamide, pyridoxine, cyanocobalamin, para-aminobenzoic acid, bioflavonoids, and mixtures thereof. Such vitamins are disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., ©1997, pp. 3-10.
Oral nutritional supplements include amino acids, lipotropics, fish oil, and mixtures thereof, as disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., ©1997, pp. 54-54e. Amino acids include, but, are not limited to L-Tryptophan, L-Lysine, Methionine, Threonine, Levocamitine or L- carnitine and mixtures thereof. Lipotropics include, but, are not limited to choline, inositol, betaine, linoleic acid, linolenic acid, and mixtures thereof. Fish oil contains large amounts of Omega-3 (N-3) Polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid.
Entenal nutritional supplements include, but, are not limited to protein products, glucose polymers, com oil, safflower oil, medium chain triglycerides as disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., ©1997, pp. 55-57.
7. Mouth and Throat Products
Other materials that can be used with the present invention include commonly known mouth and throat products. Such products are disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., ©1997, pp. 520b-527. These products include, but, are not limited to anti-fungal, antibiotic and analgesic agents.
8. Antioxidants
Antioxidants are generally recognized as useful in compositions such as those of the present invention. Antioxidants are disclosed in texts such as Cadenas and Packer, The Handbook of Antioxidants, ©1996 by Marcel Dekker. Inc. Antioxidants that may be included in the oral care composition or substance of the present invention include, but are not limited to Vitamin E, ascorbic acid, Uric acid, carotenoids, Vitamin A, flavonoids and polyphenols, herbal antioxidants, melatonin, aminoindoles, lipoic acids and mixtures thereof.
9. H-2 Antagonists
Histamine-2 (H-2 or H2) receptor antagonist compounds (H-2 antagonists) may be used in the oral care composition of the present invention. As used herein, selective H-2 antagonists are compounds that block H-2 receptors, but do not have meaningful activity in blocking histamine-1 (H-1 or H1) receptors. Selective H-2 antagonists stimulates the contraction of smooth muscle from various organs, such as the gut and bronchi; this effect can be suppressed by low concentrations of mepyramine—a typical antihistaminic drug. The pharmacological receptors involved in these mepyramine-sensitive histamine responses have been denned as H-1 receptors (Ash, A.S.F. & H.O. Schild, Brit. J. Pharmacol Chemother., Vol. 27 (1966), p. 427. Histamine also stimulates the secretion of acid by the stomach (Loew, E.R. & O. Chickering, Proc. Soc. Exp. Biol. Med., Vol. 48 (1941), p. 65), increases the heart rate (Trendelenburg, U., J. Pharmacol., Vol. 130 (1960), p. 450), and inhibits contractions in the rat uterus (Dews, P. B. & J. D. P. Graham, Brit. J. Pharmacol. Chemother., Vol. 1 (1946), p. 278); these actions cannot be antagonized by mepyramine and related drugs. The H-2 antagonists useful in the oral care compositions or substances are those that blockade the receptors involved in mepyramine-insensitive, non-H-1 (H-2), histamine responses, and do not blockade the receptors involved in mepyramine- sensitive histamine responses.
Selective H-2 antagonists are those compounds found to be H-2 antagonists through their performance in classical preclinical screening tests for H-2 antagonist function. Selective H-2 antagonists are identified as compounds which can be demonstrated to function as competitive or non-competitive inhibitors of histamine-mediated effects in those screening models specifically dependent upon H-2 receptor function, but to lack significant histamine antagonist activity in those screening models dependent upon H-1 receptor function. Specifically, this includes compounds that would be classified as described by Black, J. W., W. A. M. Duncan, C. J. Durant, C. R. Ganellin & E. M. Parsons, “Definition and Antagonism of Histamine H2-Receptors”, Nature, Vol. 236 (Apr. 21, 1972), pp. 385-390 (Black), as H-2 antagonists if assessed as described by Black through testing with the guinea pig spontaneously beating right atria in vitro assay and the rat gastric acid secretion in vivo assay, but shown to lack in significant H-1 antagonist activity relative to H-2 antagonist activity, if assessed as described by Black with either the guinea pig ileum contraction in vitro assay or the rat stomach muscle contraction in vivo assay. Preferably selective H-2 antagonists demonstrate no significant H-1 activity at reasonable dosage levels in the above H-1 assays. Typical reasonable dosage level is the lowest dosage level at which 90% inhibition of histamine, preferably 99% inhibition of histamine, is achieved in the above H-2 assays.
Selective H-2 antagonists include compounds meeting the above criteria which are disclosed in U.S. Pat. Nos. 5,294,433 and 5,364,616 Singer et al., issued Mar. 15, 1994 and Nov. 15, 1994 respectively and assigned to Procter & Gamble, wherein the selective H-2 antagonist is selected from the group consisting of cimetidine, etintidine, ranitidine, ICIA-5165, tiotidine, ORF-17578, lupitidine, donetidine, famotidine, roxatidine, pifatidine, lamtidine, BL-6548, BMY-25271, zaltidine, nizatidine, mifentidine, BMY-52368 (SKF-94482), BL-6341A, ICI-162846, ramixotidine, Wy-45727, SR-58042, BMY-25405, loxtidine, DA-4634, bisfentidine, sufotidine, ebrotidine, HE-30-256, D-16637, FRG-8813, FRG-8701, impromidine, L-643728, and HB-408. 4. Particularly preferred is cimetidine (SKF-92334), N-cyano-N′-methyl-N″-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine:
Cimetidine is also disclosed in the Merck Index, 11th edition (1989), p. 354 (entry no. 2279), and Physicians' Desk Reference, 46th edition (1992), p. 2228. Related preferred H-2 antagonists include burimamide and metiamide.
10. Analgesic Actives
Anti-pain or desensitizing agents can also be present in the oral care compositions or substances of the present invention. Such agents may include, but are not limited to, strontium chloride, potassium nitrate, natural herbs such as gall nut, Asarum, Cubebin, Galanga, scutellaria, Liangmianzhen, Baizhi, etc.
11. Anti-viral Actives
Antiviral actives useful in the present composition include any know actives that are routinely use to treat viral infections. Such anti-viral actives are disclosed in Drug Facts and Comparisons (loose leaf drug information service), Wolters Kluer Company, St. Louis, Mo., ©1997, pp. 402(a)-407(z), incorporated herein by reference in its entirety. Specific examples include anti-viral actives disclosed in U.S. Pat. No. 5,747,070, issued May 5, 1998 to Satyanarayana Majeti, incorporated herein by reference in its entirety. Said Patent discloses the use of stannous salts to control viruses. Stannous salts and other anti-viral actives are described in detail in Kirk & Othmer, Encyclopedia of Chemical Technology, Third Edition, Volume 23, Wiley-lnterscience Publishers (1982), pp. 42-71, incorporated herein by reference in its entirety. The stannous salts that may be used in the present invention would include organic stannous carboxylates and inorganic stannous halides. While stannous fluoride may be used, it is typically used only in combination with another stannous halide or one or more stannous carboxylates or another therapeutic agent.
12. Other Ingredients
In addition to the above materials of the composition of the present invention, a number of other components may desirably be added to the oral care substance. Additional components include, but are not limited to, flavoring agents, sweetening agents, xylitol, opacifiers, coloring agents, surfactants, and chelants such as ethylenediaminetetraacetic acid. Suitable flavoring agents include, but are not limited to, oil of peppermint, oil of sassafras, clove bud oil, peppermint, menthol, anethole, thymol, methyl salicylate, eucalyptol, cassia, 1-menthyl acetate, sage, eugenol, parsley oil, oxanone, oil of wintergreen, alpha-irisone, oil of spearmint, marjoram, lemon, orange, banana, propenyl guaethol, innamon, and mixtures thereof.
Pigments may also added to the compositions herein to more precisely indicate the locations at which the composition has actually been applied, allowing the user to apply the composition more thoroughly or evenly. However, such pigments are not intended to mask stains that may exist on the tooth surfaces.
These additional ingredients can also be used in place of the compounds disclosed above.
The optional release liner may be formed from any material which exhibits less affinity for the oral care substance than the oral care substance exhibits for itself and for the backing strip. The release liner preferably comprises a rigid sheet of material such as polyethylene, paper, polyester, or other material which is then coated with a non-stick type material. The release liner material may be coated with wax, silicone, teflon, fluoropolymers, or other non-stick type materials. A preferred release liner is Scotchpak®, produced by 3M. The release liner may be cut to substantially the same size and shape as the backing strip or the release liner may be cut larger than the backing strip to provide a readily accessible means for separating the material from the backing strip. The release liner may be formed from a brittle material which cracks when the backing strip is flexed or from multiple pieces of material or a scored piece of material. Alternatively, the release liner may be in two overlapping pieces such as a typical adhesive strip bandage design. A further description of materials suitable as release agents is found in Kirk-Othmer Encyclopedia of Chemical Technology, Fourth Edition, Volume 21, pp. 207-218, incorporated herein by reference.
The following examples further describe and demonstrate embodiments within the scope of the present invention. The examples are given solely for the purpose of illustration and are not to be construed as limitations of the present invention, as many variations thereof are possible without departing from the spirit and scope of the invention.
One example of a preferred backing strip is a 0.013 mm thick piece of polyethylene film. The backing strip may be provided with an array of shallow pockets, typically 0.4 mm across and 0.1 mm deep. The backing strip has a flexural stiffness of about 0.6 grams/centimeter as measured on a Handle-O-Meter, model #211-300, available from Thwing-Albert Instrument Co. of Philadelphia, Pa., as per test method ASTM D2923-95.
Another example of a preferred backing strip is a 0.3 mm thick piece of substantially water soluble material such as rice paper. Another example of a preferred backing strip is a 0.3 mm thick piece of pullulan paper.
Any of the oral care compositions described below can be used with any of the backing strips described herein.
TABLE 1 |
Hydrophobic Oral Care Composition |
Component | Ex. 1 | Ex. 2 | Ex. 3 | Ex. 4 | Ex. 5 | Ex. 6 |
Organosiloxane Resin1 | 25 | 25 | 24.6 | 25 | 25 | 25 |
Silicone Gum2 | 12.5 | 4.2 | 3.5 | 2.5 | 1.8 | — |
Oral Care Substance3 | 17 | 17 | 17 | 17 | 17 | 17 |
Carrier4 | 44.5 | 52.8 | 53.9 | 54.5 | 55.2 | 57.0 |
Bentone Clay5 | 1 | 1 | 1 | 1 | 1 | 1 |
100 | 100 | 100 | 100 | 100 | 100 | |
1E.g., MQ resin available as 1170-002 from General Electric. | ||||||
2E.g., Dimethicone gum available as SE 30 or SE 63 from General Electric. | ||||||
3E.g., Sodium percarbonate as a dry powder. | ||||||
4E.g., Isododecane or a 50/50 mixture of ethyl acetate and butanone or a mixture of ethyl acetate, propyl acetate and HFE. The percentage of each individual solvent component in the mixed solvent systems can vary from 0 to 100%, respectively. | ||||||
5 |
TABLE 2 |
Hydrophobic Oral Care Composition |
Component | Ex. 1 | Ex. 2 | Ex. 3 | Ex. 4 |
Organosiloxane Resin1 | 33.43 | 33.43 | 35.14 | 33.43 |
Silicone Gum2 | 5.57 | 5.57 | 5.86 | 5.57 |
Oral Care Substance3 | 19.00 | 12.00 | 19.00 | 19.00 |
Ethyl acetate | 8.00 | 8.50 | 8.00 | 8.00 |
Bentone Gel4 | 10.00 | 10.00 | 10.00 | 10.00 |
DC-200/350 cst5 | 1.00 | 1.00 | 2.00 | 1.00 |
HFE-71006 | 21.00 | 26.00 | — | 19.50 |
N-propyl acetate | 2.00 | 2.00 | — | 2.00 |
2-butanone | — | — | 19.00 | — |
Aerosil 2007 (SiO2) | — | — | 1.00 | — |
Flavor | — | 1.50 | — | 1.50 |
TOTAL | 100 | 100 | 100 | 100 |
1E.g., MQ resin available as 1170-002 from General Electric. | ||||
2E.g., Dimethicone gum available as SE 30 from General Electric. | ||||
3E.g., Sodium percarbonate as a dry powder. | ||||
4Bentone Gel IPM available from Rheox. | ||||
5DC-200/350 is: dimethylpolysiloxane, CAS# 9016-00-6, from Dow Corning. | ||||
6HFE-7100 is a mixture of Methyl Nonafluoroisobutyl Ether, CAS# 163702-08-7 and Methyl Nonafluorobutyl Ether, CAS# 163702-07-6 manufactured by 3M Co. | ||||
7Aerosil 200 is silicon dioxide (chemically prepared), CAS# 112945-52-5, from Degussa AG. |
The compositions of Tables 1 and 2 are non-aqueous. The oral care substances are dispersed or dissolved in a solution comprising the organosiloxane resin, the fluid diorganopolysiloxane polymer, the carrier, and the rheology modifier.
The hydrophobic compositions of Tables 1 and 2 are suitably prepared as follows. Three hundred (300) grams of organosiloxane resin solution (for example, 43.7% MQ resin in isododecane, or in a 50/50 mixture of ethyl acetate and butanone, or in a mixture of ethyl acetate, propyl acetate and HFE) are mixed with 147.30 grams of fluid diorganopolysiloxane polymer solution (for example, 50% SE30 silicone gum in isododecane or, a 50/50 mixture of ethyl acetate and butanone, or a mixture of ethyl acetate, propyl acetate, and HFE.). The oral care substances are then dispersed in the resin/gum mixture. This method may be carried out without the presence of the silicone gum.
All oral care substances described herein can formulated as described above.
TABLE 3 |
Whitening Compositions |
Component | Ex. 1 | Ex. 2 | Ex. 3 | ||
Organosiloxane Resin1 | 48.00 | 48.00 | 36.00 | ||
Silicone Gum2 | 8.00 | 6.86 | 9.00 | ||
Oral Care Substance3 | 19.00 | 12.00 | 19.00 | ||
Rheology Modifier4 | 13.00 | 15.00 | 10.00 | ||
DC-200/350 cst5 | 5.00 | 10.00 | 25.00 | ||
Surfactant6 | 6.00 | 8.14 | — | ||
Flavor | 1.00 | — | 1.00 | ||
1E.g., MQ resin available as 1170-002 from General Electric. | |||||
2E.g., Dimethicone gum available as SE 30 from General Electric. | |||||
3E.g., Sodium percarbonate as a dry powder. | |||||
4Bentone Gel IPM available from Rheox. | |||||
5DC-200/350 is: dimethylpolysiloxane, CAS# 9016-00-6, from Dow Corning. | |||||
6Can be anionic, cationic, or neutral |
The compositions of Table 3 may be prepared as above, except that a carrier is not added, and the surfactant and flavorant are added after the resin and silicone gum have been mixed until completely dissolved.
All oral care substances described herein can formulated as described above.
TABLE 4 |
Whitening Compositions |
Component | Ex. 1 | Ex. 2 | Ex. 3 | Ex. 4 | Ex. 5 | Ex. 6 |
Ethyl Acetate | 18.00 | 14.85 | 22.25 | 20.88 | 18.96 | 18.00 |
2-Butanone | 18.00 | 13.00 | 13.10 | 20.88 | 10.00 | 18.00 |
Isododecane | — | 10.00 | — | — | 11.54 | — |
Limonene | — | 4.35 | — | — | 5.00 | — |
MQ Resin | 28.00 | 32.50 | 26.50 | 27.33 | 36.00 | 31.50 |
SE 30 Silicon | 7.00 | — | 8.80 | 13.67 | — | — |
Gum | ||||||
Silicone Visc- | — | — | — | — | — | 3.50 |
100M | ||||||
Silicone Fluid | — | 6.50 | — | — | 9.00 | — |
10 cStk | ||||||
Bentone Gel | 10.00 | — | 6.40 | 9.95 | — | 10.00 |
ISD | ||||||
Claytone HY | — | 2.45 | — | — | 3.00 | — |
Cab-o-Sil | — | — | 1.50 | — | — | — |
Sodium | 19.00 | — | 19.00 | 7.00 | — | 19.00 |
Percarbonate | ||||||
Carbamide | — | 15.00 | — | — | 5.00 | — |
Peroxide | ||||||
Bismuth | — | 1.15 | — | — | — | — |
Oxychloride | ||||||
Titanium | — | — | 1.00 | — | 1.50 | — |
Dioxide | ||||||
Flavor Oil | — | — | 0.15 | — | — | — |
Sodium | — | — | 1.00 | — | — | — |
Fluoride | ||||||
Sodium | — | 0.20 | 0.30 | 0.30 | — | — |
Saccharin | ||||||
100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | |
TABLE 5 |
Oral Care Compositions |
Component | Ex. 1 | Ex. 2 | Ex. 3 | Ex. 4 | Ex. 5 |
Ethyl Acetate | 24.50 | 27.75 | 22.00 | 19.96 | 21.10 |
2-Butanone | 24.50 | 16.30 | 22.00 | 10.00 | 21.10 |
Isododecane | — | — | — | 11.54 | — |
Limonene | — | — | — | 5.00 | — |
MQ Resin | 30.40 | 33.00 | 28.80 | 36.00 | 32.84 |
SE 30 Silicon Gum | 7.60 | 11.00 | 14.40 | — | 8.21 |
|
— | — | — | 9.00 | — |
Bentone Gel ISD | 10.00 | 8.00 | 10.50 | — | 11.75 |
Claytone HY | — | — | — | 3.00 | — |
Cab-o-Sil | — | 1.50 | — | — | — |
Bismuth Oxychloride | — | 1.00 | — | — | — |
Titanium Dioxide | — | — | — | 2.00 | — |
Flavor Oil | — | 0.15 | — | — | — |
Potassium Nitrate | — | — | — | — | 5.00 |
Sodium Chlorite | 3.00 | — | — | — | — |
Tripolyphosphate | — | — | — | 2.50 | — |
Sodium Fluoride | — | 1.00 | — | 1.00 | — |
Chlorhexidine | — | — | 2.00 | — | — |
Gluconate | |||||
Sodium Saccharin | — | 0.30 | 0.30 | — | — |
100.00 | 100.00 | 100.00 | 100.00 | 100.00 | |
TABLE 6 |
Oral Care Compositions |
Component | Ex. 1 | Ex. 2 | Ex. 3 | Ex. 4 | Ex. 5 | Ex. 6 |
Ethyl Acetate | 26.00 | 22.00 | 35.00 | 28.00 | 25.77 | 23.00 |
2-Butanone | 25.95 | 17.00 | 9.00 | 14.50 | 25.50 | 23.45 |
Isododecane | — | 10.00 | — | — | 5.00 | — |
Limonene | — | 4.00 | — | — | — | — |
MQ Resin | 28.00 | 32.50 | 33.00 | 35.00 | 27.00 | 28.00 |
SE 30 Silicon | 7.00 | — | 11.00 | 5.00 | 3.00 | 7.00 |
Gum | ||||||
Silicone Fluid | — | 6.50 | — | — | — | — |
10 cStk | ||||||
Bentone Gel | 10.00 | — | 8.00 | 10.00 | 10.00 | — |
ISD | ||||||
Claytone HY | — | 2.00 | — | — | — | 7.00 |
Cab-o-Sil M7D | — | — | 1.50 | — | — | — |
Bismuth | — | 5.00 | — | — | — | 10.00 |
Oxychloride | ||||||
Titanium | 3.00 | — | 1.00 | 5.00 | 2.00 | — |
Dioxide | ||||||
Flavor Oil | — | — | 0.10 | — | 0.15 | 0.15 |
Polymethylsil- | — | — | 1.00 | — | — | — |
sesquioxane | ||||||
Polymethyl- | 3.00 | 1.00 | — | — | 0.50 | — |
| ||||||
Nylon | ||||||
12 | — | — | — | 2.00 | — | 1.00 |
Silica | — | — | — | — | 0.50 | — |
FD&C Yellow | 0.05 | — | 0.10 | — | 0.05 | 0.10 |
#5 Al Lake | ||||||
Iron Oxide, | — | — | — | 0.50 | 0.03 | — |
Red | ||||||
Sodium | — | — | 0.30 | 13 | 0.50 | 0.30 |
Saccharin | ||||||
100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | |
TABLE 7 |
Ethanol Based Compositions |
Component | Ex. 1 | Ex. 2 | Ex. 3 | Ex. 4 | Ex. 5 | Ex. 6 |
Ethanol | 20.90 | 35.80 | 41.70 | 25.89 | 23.10 | 23.55 |
Ethyl Acetate | — | — | — | — | 4.95 | — |
Ethyl Butyrate | 10.30 | — | — | 12.74 | 11.75 | 10.9 |
Isoamyl | — | — | — | — | — | 2.65 |
Acetate | ||||||
Isododecane | — | 13.00 | — | — | — | — |
MQ Resin | 35.10 | 32.85 | 42.75 | 47.00 | 42.00 | 41.80 |
Silicone Visc- | — | — | — | — | 7.15 | — |
100M | ||||||
Silicone Fluid | 7.80 | — | — | 9.65 | — | 8.55 |
100 cSt | ||||||
Silicone Fluid | 3.90 | — | 11.40 | — | 4.00 | — |
10 cStk | ||||||
Silwet L-7500 | — | — | — | — | — | 6.58 |
|
1.50 | — | 2.00 | 1.85 | 1.35 | 1.97 |
Claytone APA | — | 2.00 | — | — | — | — |
Cab-o-Sil | — | — | — | — | 0.45 | — |
Sodium | 19.00 | — | — | — | — | — |
Percarbonate | ||||||
Carbamide | — | 15.00 | — | — | — | — |
Peroxide | ||||||
Potassium | — | — | — | — | 5.00 | — |
Nitrate | ||||||
Tripoly- | — | — | — | — | — | 2.50 |
phosphate | ||||||
Chlorhexidine | — | — | — | 2.57 | — | — |
Digluconate | ||||||
Titanium | 1.50 | — | 2.00 | — | — | 1.50 |
Dioxide | ||||||
Flavor Oil | — | — | 0.05 | — | — | — |
Sodium | — | — | 0.10 | — | 0.25 | — |
Fluoride | ||||||
Sodium | — | 0.20 | 13 | 0.30 | — | — |
Saccharin | ||||||
100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | |
The compositions of Tables 4-7 are suitably prepared as follows. Add the solvents into a container suitable to minimize solvent loss. Add the rheology modifiers and mix until well dispersed. Add the silicone resin and mix until completely dissolved. Add the silicone gum and/or silicone fluids and mix until completely dissolved. At this time add any salts such as sodium percarbonate and/or other oral care actives, aesthetic ingredients such as opacifiers, sweeteners, dyes, and flavors. Continue mixing until homogeneous. Additional high shear mixing may be used to promote the mixing. Pack into airtight containers.
Alternatively premixes of the silicone resin and/or the silicone gum may be prepared prior to incorporation into the final blending step to facilitate silicone dissolution and ease of manufacturing. Depending on the formula composition, the order of ingredient addition may also vary such as the addition of the rheology modifier(s) may be moved to a later step allowing lower viscosity to be maintained until the later stages of the blending step.
After making the composition according to the any of the methods described above, cast the composition onto a piece of backing strip material (rice paper, for example). Then dry it for about 10-60 minutes to allow some of the volatile component of the carrier, if present, to volatize. A adhesive film will form on the backing strip material. The thickness of adhesive film can be controlled by the amount of the composition used when the composition is cast onto the backing strip. Then cut the backing strip into the desired shape and size.
Methods of Use
In practicing the present invention, a backing strip is applied to the desired oral surface by the wearer. The side of the strip facing the oral surface is coated with an oral care composition that is preferably in a highly viscous state.
The backing strip readily conforms to the oral care surface during application by lightly pressing it there against. The backing strip can be left in oral cavity if it is substantially water soluble or can be peeled off if it is substantially water insoluble. After the strip has dissolved in-situ or has been peeled away by the user, the oral care composition remains on the oral surfaces as a thin a film.
In practicing the present invention, the user need only apply a backing strip that has been coated with composition herein that contains the oral care substance or substances necessary in order to obtain a desired effect, e.g., whitening, breath freshening, caries prevention, pain relief, gum health, tartar control, etc. to the tooth surfaces in the areas desired. The compositions may also be applied to other surfaces of the oral cavity, such as the gingival or mucosal tissues, or to any other oral cavity surface.
Prolonged delivery of the oral care substance is made possible as the oral care substance is released from the film over time. Then, any residual oral care substance may be easily removed by wiping, brushing or rinsing the oral surface after a desired period of time has elapsed, or in the normal course of tooth brushing or other oral care activities. Without being bound by theory, it is believed that the film will last from about 2 hours to 8 hours regardless of the reactivity of the oral care substance. Preferably, the compositions are almost unnoticeable when applied to the oral cavity.
It is not necessary to prepare the oral cavity before using the system of the present invention. For example, the user may or may not choose to brush the teeth or rinse the mouth before using the system. The surfaces of the oral cavity are neither required to be rigorously dried nor to be excessively wet with saliva or water before the system is used. However, it is believed that adhesion to the tooth enamel surfaces will be improved if the teeth are dry when the system is applied.
It should be understood that the present invention relates not only to methods for delivering an oral care substance to the oral cavity of a human, but also to methods of delivering an oral care substance to the oral cavity of an animal, e.g., household pets or other domestic animals, or animals kept in captivity.
It is understood that the examples and embodiments described herein are for illustrative purposes only and that various modifications or changes in light thereof will be suggested to one skilled in the art without departing from the scope of the present invention.
Claims (41)
1. A delivery system for delivering an oral care substance to the oral cavity, the delivery system comprising:
(a) a removable backing strip having sufficient flexibility so as to be readily conformable to an oral surface when the delivery system is placed thereagainst; and
(b) an oral care composition that forms a film when applied to the backing strip such that when the delivery system is placed on the oral surface the oral care composition contacts the oral surface, the oral care composition comprising:
(i) an organosiloxane resin;
(ii) a rheology modifier; and
(iii) at least one oral care substance;
wherein the oral care composition remains on the oral surface after the backing strip is removed.
2. The delivery system of claim 1 wherein the organosiloxane resin is present in the composition at a level of from about 5% to about 70%.
3. The delivery system of claim 2 wherein the organosiloxane resin is selected from the group consisting of (CH3)3SiO)0.5 “M” units, (CH3)2SiO “D” units, (CH3)SiO1.5 “T” units, SiO2 “Q” units, and mixtures thereof.
4. The delivery system of claim 1 wherein the oral care substance includes at least one oral care active selected from the group consisting of a teeth whitening active, an anti-tartar agent, a fluoride ion source, an anti-microbial agent, an anti-inflammatory agent, one or more nutrients, a mouth and throat product, an anti-fungal, an antibiotic, an antioxidant, an H2 antagonist, an analgesic active, an anti-viral agent, flavoring agents, sweetening agents, xylitol, opacifiers, coloring agents, surfactants, chelants, pigments, and mixtures thereof.
5. The delivery system of claim 4 wherein the oral care substance comprises from about 0.01% to about 50% of the oral care composition.
6. The delivery system of claim 5 wherein the oral care substance is a teeth whitening active selected from the group consisting peroxides, metal chlorites, perborates, percarbonates, peroxyacids, persulfates, and mixtures thereof.
7. The delivery system of claim 1 wherein the rheology modifier is selected from the group consisting of organo modified clays, silicas, polyethylene, and mixtures thereof.
8. The delivery system of claim 7 wherein the rheology modifier is present in the oral care composition at a level of from about 0.1% to about 30%.
9. A delivery system for delivering an oral care substance to the oral cavity, the delivery system comprising:
(a) a removable backing strip having sufficient flexibility so as to be readily conformable to an oral surface when the delivery system is placed thereagainst; and
(b) an oral care composition applied to the backing strip such that when the delivery system is placed on the oral surface the oral care composition contacts the oral surface, the oral care composition comprising:
(i) an organosiloxane resin;
(ii) a fluid diorganopolysiloxane-based polymer;
(iii) a rheology modifier; and
(iv) at least one oral care substance;
wherein the oral care composition remains on the oral surface after the backing strip is removed.
10. The delivery system of claim 9 wherein the oral care composition further comprises a carrier capable of solubilizing the organosiloxane resin and the fluid diorganopolysiloxane-based polymer.
11. The delivery system of claim 10 wherein the fluid diorganopolysiloxane-based polymer comprises repeating units of the formula (R2SiO)n, where R is a monovalent hydrocarbon radical group containing from 1 to 6 carbon atoms.
12. The delivery system of claim 1 9 wherein the fluid diorganopolysiloxane polymer is poly(dimethylsiloxane).
13. The delivery system of claim 9 wherein the ratio of organosiloxane resin to fluid diorganopolysiloxane-based polymer is from about 10:1 to about 1:10.
14. The delivery system of claim 10 wherein the carrier is selected from the group consisting of hydrocarbon oils, volatile silicones, non-hydrocarbon solvents, and-mixtures thereof.
15. The delivery system of claim 9 wherein the oral care substance includes at least one oral care active selected from the group consisting of a teeth whitening active, an anti-tartar agent, a fluoride ion source, an anti-microbial agent, an anti-inflammatory agent, one or more nutrients, a mouth and throat product, an anti-fungal, an antibiotic, an antioxidant, an H2 antagonist, an analgesic active, an anti-viral agent, flavoring agents, sweetening agents, xylitol, opacifiers, coloring agents, surfactants, chelants, pigments, and mixtures thereof.
16. The delivery system of claim 15 wherein the oral care active comprises from about 0.01% to about 50% of the oral care composition.
17. The delivery system of claim 16 wherein the oral care active is a teeth whitening active selected from the group consisting peroxides, metal chlorites, perborates, percarbonates, peroxyacids, persulfates, and mixtures thereof.
18. The delivery system of claim 9 wherein the rheology modifier is selected from the group consisting of organo modified clays, silicas, polyethylene, and mixtures thereof.
19. The delivery system of claim 9 wherein the rheology modifier is present in the oral care composition at a level of from about 0.1% to about 30%.
20. The delivery system of either of claim 1 or claim 9 wherein the backing strip is substantially water insoluble.
21. The delivery system of claim 20 wherein the backing strip is a polymer film having a nominal thickness of less than about 0.1 mm and selected from the group consisting of polyethylene, ethylvinylacetate, polyesters, ethylvinyl alcohol, pullulan film, and combinations thereof.
22. The delivery system of claim 21 wherein the backing strip has a peel force, of less than 50 grams.
23. The delivery system of either of claim 1 or claim 9 wherein the backing strip is substantially water soluble.
24. The delivery system of claim 23 wherein the backing strip is selected from the group consisting of rice paper, pullulan paper, agar film, starch paper, a natural gum, and mixtures thereof.
25. A method for delivering an oral care substance to at least one surface of the oral cavity, comprising the steps of: (1) applying the backing strip of the delivery system with the oral care composition of either of claim 1 or claim 9 coated thereon to the surface(s) of the oral cavity; (2) removing the backing strip from the surface(s) of the oral cavity, wherein the oral care composition remains on the surface(s) of the oral cavity after the backing strip is removed.
26. The method of claim 25 wherein the oral care composition comprises a teeth whitening active and the oral cavity surface to which the composition is applied is the enamel of the teeth.
27. A method for delivering an oral care substance to at least one surface of the oral cavity, comprising the steps of: (1) applying the backing stip of the delivery system with the oral care composition of either of claim 1 or claim 9 coated thereon to the surface(s) of the oral cavity; (2) allowing the backing strip to dissolve in situ, wherein the oral care composition remains on the surface(s) of the oral cavity after the backing strip has dissolved.
28. The method of claim 27 wherein the oral care composition comprises a teeth whitening active and the oral cavity surface to which the composition is applied is the enamel of the teeth.
29. A tooth whitening system, comprising:
a backing material comprising a water soluble material that dissolves during use; and
a tooth whitening composition comprising an organosiloxane resin applied to one side of said backing material, wherein the system is sized for application to both front and rear surfaces of a plurality of adjacent teeth.
30. The tooth whitening system of claim 29 , wherein said tooth whitening composition comprises a peroxide.
31. The tooth whitening system of claim 30 , wherein said peroxide is hydrogen peroxide.
32. The tooth whitening system of claim 30 , wherein said peroxide has a concentration between about 0.1% and about 20 % by weight of the tooth whitening composition.
33. The tooth whitening system of claim 29 , wherein said water soluble material is selected from the group consisting of agar film, starch paper, rice paper, a natural gum, pullulan paper, and mixtures thereof.
34. The tooth whitening system of claim 29 , wherein said tooth whitening composition is a laminate.
35. The tooth whitening system of claim 29 , wherein said backing material is a laminate.
36. The tooth whitening system of claim 29 , wherein said backing material has a width between about 1.5 cm and about 2 cm.
37. The tooth whitening system of claim 29 , wherein said water soluble material is substantially water soluble.
38. The tooth whitening system of claim 29 , wherein the tooth whitening composition forms a film when applied to one side of said backing material.
39. The tooth whitening system of claim 29 , further comprising a release liner.
40. The tooth whitening system of claim 29 , further comprising a rheology modifier.
41. The tooth whitening system of claim 40 , wherein the rheology modifier is selected from the group consisting of: organo modified clays, silicas, polyethylene, and mixtures thereof.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/927,655 USRE42126E1 (en) | 1999-07-02 | 2000-06-30 | Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip |
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9915130 | 1999-07-02 | ||
US9915131 | 1999-07-02 | ||
PCT/US2000/015891 WO2001001940A1 (en) | 1999-07-02 | 2000-06-09 | Compositions comprising organosiloxane resins for delivering oral care substances |
PCT/US2000/015890 WO2001001939A1 (en) | 1999-07-02 | 2000-06-09 | Compositions comprising organosiloxane resins for delivering oral care substances |
US10/927,655 USRE42126E1 (en) | 1999-07-02 | 2000-06-30 | Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip |
PCT/US2000/018188 WO2001001958A1 (en) | 1999-07-02 | 2000-06-30 | Delivery system for oral care compositions comprising organosiloxane reins using a removable backing strip |
US10/019,032 US6649147B1 (en) | 1999-07-02 | 2000-06-30 | Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/019,032 Reissue US6649147B1 (en) | 1999-07-02 | 2000-06-30 | Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip |
Publications (1)
Publication Number | Publication Date |
---|---|
USRE42126E1 true USRE42126E1 (en) | 2011-02-08 |
Family
ID=32852896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/927,655 Expired - Fee Related USRE42126E1 (en) | 1999-07-02 | 2000-06-30 | Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip |
Country Status (22)
Country | Link |
---|---|
US (1) | USRE42126E1 (en) |
EP (2) | EP1200064B1 (en) |
JP (1) | JP3927030B2 (en) |
KR (1) | KR20020032521A (en) |
CN (1) | CN1204875C (en) |
AT (2) | ATE285220T1 (en) |
AU (3) | AU5907500A (en) |
BR (1) | BR0012145A (en) |
CA (2) | CA2373983C (en) |
CZ (1) | CZ20014709A3 (en) |
DE (2) | DE60002471T2 (en) |
ES (1) | ES2199168T3 (en) |
HK (1) | HK1047035B (en) |
HU (1) | HUP0201620A3 (en) |
IL (1) | IL147265A (en) |
MA (1) | MA25681A1 (en) |
MX (1) | MXPA02000262A (en) |
NO (1) | NO20020004L (en) |
PL (1) | PL200936B1 (en) |
RU (1) | RU2223746C2 (en) |
SK (1) | SK19412001A3 (en) |
WO (3) | WO2001001942A1 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110009834A1 (en) * | 2008-03-15 | 2011-01-13 | Lts Lohmann Therapie-Systeme Ag | Gingival wafer |
US20130281904A1 (en) * | 2010-08-11 | 2013-10-24 | Neodyne Biosciences, Inc. | Wound or skin treatment devices and methods |
USD733302S1 (en) * | 2014-03-11 | 2015-06-30 | Mdt Micro Diamond Technologies Ltd | Dental articulating device |
US9205089B2 (en) | 2011-04-29 | 2015-12-08 | Massachusetts Institute Of Technology | Layer processing for pharmaceuticals |
US9649226B2 (en) | 2007-08-03 | 2017-05-16 | Neodyne Biosciences, Inc. | Skin treatment devices with tensioning features |
US9889046B2 (en) | 2003-05-29 | 2018-02-13 | The Board Of Trustees Of The Leland Stanford Junior University | Skin treatment devices and methods with pre-stressed configurations |
US10213960B2 (en) | 2014-05-20 | 2019-02-26 | Massachusetts Institute Of Technology | Plasticity induced bonding |
US10420557B2 (en) | 2007-08-03 | 2019-09-24 | Neodyne Biosciences, Inc. | Skin straining devices and methods |
US10857037B2 (en) | 2007-08-03 | 2020-12-08 | Neodyne Biosciences, Inc. | Controlled strain skin treatment devices and methods |
US11246763B2 (en) | 2006-08-03 | 2022-02-15 | The Board Of Trustees Of The Leland Stanford Junior University | Skin treatment devices and methods with pre-stressed configurations |
US20230027167A1 (en) * | 2019-12-19 | 2023-01-26 | Lg Household & Health Care Ltd. | Patch attachable to teeth |
US11980738B1 (en) | 2019-12-10 | 2024-05-14 | Neodyne Biosciences, Inc. | Injection and infusion site treatment devices and methods |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6096328A (en) * | 1997-06-06 | 2000-08-01 | The Procter & Gamble Company | Delivery system for an oral care substance using a strip of material having low flexural stiffness |
DE60002471T2 (en) | 1999-07-02 | 2004-02-19 | The Procter & Gamble Company, Cincinnati | COMPOSITIONS FOR RELEASING ORGANOSILOXANE RESINS CONTAINING ORAL CARE ACTIVE SUBSTANCES BY USING A REMOVABLE CARRIER STRIP |
USRE44145E1 (en) | 2000-07-07 | 2013-04-09 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
PL362250A1 (en) * | 2000-10-25 | 2004-10-18 | The Procter & Gamble Company | Dental care compositions |
US20050215727A1 (en) | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
US8541021B2 (en) | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
RU2276998C2 (en) | 2001-05-01 | 2006-05-27 | Институт Нефтехимического Синтеза Имени А.В. Топчиева Российской Академии Наук | Hydrogel compositions |
US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
US20050113510A1 (en) | 2001-05-01 | 2005-05-26 | Feldstein Mikhail M. | Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components |
US8206738B2 (en) | 2001-05-01 | 2012-06-26 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
US6946142B2 (en) * | 2001-06-23 | 2005-09-20 | Lg Household & Healthcare Ltd. | Multi-layer patches for teeth whitening |
US8956160B2 (en) | 2002-07-02 | 2015-02-17 | Ranir, Llc | Device and method for delivering an oral care agent |
US8524200B2 (en) | 2002-09-11 | 2013-09-03 | The Procter & Gamble Company | Tooth whitening products |
US20050069502A1 (en) * | 2003-08-15 | 2005-03-31 | Chopra Suman K. | Hydrophobic polymer carrier based liquid tooth whitening composition |
US8815215B2 (en) | 2003-08-15 | 2014-08-26 | Colgate-Palmolive Company | Hydrophobic tooth whitening system and methods of use |
US20050036957A1 (en) | 2003-08-15 | 2005-02-17 | Michael Prencipe | Tooth whitening dental tray and method of use |
CN1893917B (en) * | 2003-12-17 | 2011-06-29 | 宝洁公司 | Emulsion composition for delivery of bleaching agents to teeth |
US8658201B2 (en) | 2004-01-30 | 2014-02-25 | Corium International, Inc. | Rapidly dissolving film for delivery of an active agent |
US7118732B2 (en) * | 2004-05-10 | 2006-10-10 | Colgate-Palmolive Company | Tooth-whitening compositions comprising silicone polymer and methods therefor |
DE102004041333A1 (en) * | 2004-08-20 | 2006-03-09 | Dental-Kosmetik Gmbh & Co. Kg | Tooth gel, useful for non-therapeutic treatment and bleaching of teeth, comprises peroxy compound (measured as hydrogen peroxide) and additionally trialkyl siloxy silicates (e.g. trimethylsiloxysilicate) |
US20060099550A1 (en) | 2004-11-10 | 2006-05-11 | Ranir/Dcp Corporation | Device and method for delivering an oral care agent |
GB0502046D0 (en) | 2005-02-01 | 2005-03-09 | Sinclair Pharmaceuticals Ltd | Method |
JP4716360B2 (en) * | 2005-04-28 | 2011-07-06 | ファインフーズ株式会社 | Caries bandage |
US8834854B2 (en) | 2008-02-22 | 2014-09-16 | Ranir, Llc | Oral treatment compositions and related methods of manufacture |
EP2313064A2 (en) * | 2008-07-15 | 2011-04-27 | BASF Catalysts LLC | Methods, systems and devices for administration of chlorine dioxide |
EP2387394B1 (en) | 2009-01-14 | 2018-05-02 | Corium International, Inc. | Transdermal administration of tamsulosin |
US20100196512A1 (en) | 2009-02-04 | 2010-08-05 | Basf Catalyst Llc | Treatment of Non-Oral Biological Tissue with Chlorine Dioxide |
EP2588091B1 (en) * | 2010-07-02 | 2020-04-15 | The Procter and Gamble Company | Methods of delivering a health care active by administering personal health care articles comprising a filament |
US8986005B2 (en) * | 2010-09-12 | 2015-03-24 | Discus Dental, Llc | Strip for transferring a therapeutic composition to a tooth |
EP2938318B1 (en) * | 2012-12-27 | 2019-09-04 | Unilever N.V. | Oral care composition having an adduct of clay and antibacterial agent |
RU2015137154A (en) * | 2013-04-10 | 2017-05-16 | Дзе Проктер Энд Гэмбл Компани | Oral Care Compositions Containing Particles of Polyorganosilsesesquioxane |
JP2017524755A (en) * | 2014-06-06 | 2017-08-31 | オーペーエーエス コーポレイション オサケユイチア | A lump containing a functional compound and a viscosity modifier |
EP3324919B1 (en) * | 2015-09-14 | 2020-11-25 | Colgate-Palmolive Company | Whitening systems for hydrophobic whitening gels |
ES2792774A1 (en) * | 2019-05-07 | 2020-11-11 | Barreiro Javier Gomez | Dental Protection Against Acidic Agents (Machine-translation by Google Translate, not legally binding) |
Citations (316)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2835628A (en) | 1957-04-01 | 1958-05-20 | Jacob A Saffir | Means for treating teeth |
DE1104116B (en) | 1959-02-05 | 1961-04-06 | Dr Rudolf Eisenhut | Auxiliary strips to hold the filling when sealing teeth |
US3070102A (en) | 1960-05-12 | 1962-12-25 | Harold B Macdonald | Throw-away toothbrush and package |
US3096202A (en) | 1960-08-30 | 1963-07-02 | Johnson & Johnson | Polyvinyl pyrrolidone pressure sensitive adhestive and tape containing same |
CA681997A (en) | 1964-03-10 | Minnesota Mining And Manufacturing Company | Extrudable polypyrrolidone compositions | |
GB1142325A (en) | 1965-05-14 | 1969-02-05 | Higham Stanley Russell | Means for administering drugs |
GB1240411A (en) | 1968-05-31 | 1971-07-21 | Gerhard Weinz | Pharmaceutically treated tab for application to the mucous membrane of a living organism |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3625215A (en) | 1970-07-09 | 1971-12-07 | Sverre Quisling | Dental sheaths |
US3640741A (en) | 1970-02-24 | 1972-02-08 | Hollister Inc | Composition containing gel |
US3657413A (en) | 1969-08-28 | 1972-04-18 | Block Drug Co | Antiseptic composition containing peroxide glycerol and carboxypolymethylene polymer |
US3688406A (en) | 1970-08-07 | 1972-09-05 | William I Porter | Apparatus for and method of applying decay retardant compositions to teeth |
US3754332A (en) | 1970-09-09 | 1973-08-28 | L Warren | Treatment member |
US3784390A (en) | 1971-07-23 | 1974-01-08 | Hayashibara Biochem Lab | Shaped bodies of pullulan and their use |
US3844266A (en) | 1972-10-10 | 1974-10-29 | D Peterson | Capacitor discharge ignition circuit |
US3902509A (en) | 1972-10-10 | 1975-09-02 | Colgate Palmolive Co | Disposable device for cleaning teeth |
US3955281A (en) | 1974-12-05 | 1976-05-11 | Pacemaker Corporation | Disposable dental tray for topical application of fluoride gel and other dental medications |
US3972995A (en) | 1975-04-14 | 1976-08-03 | American Home Products Corporation | Dosage form |
US3998215A (en) | 1968-12-18 | 1976-12-21 | Minnesota Mining And Manufacturing Company | Bio-medical electrode conductive gel pads |
US4029757A (en) | 1975-12-15 | 1977-06-14 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical unit dosage forms |
US4029758A (en) | 1975-12-15 | 1977-06-14 | Hoffmann-La Roche Inc. | Preparation of pharmaceutical unit dosage forms |
US4031200A (en) | 1975-12-15 | 1977-06-21 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical unit dosage forms |
US4032627A (en) * | 1973-04-02 | 1977-06-28 | Koh-I-Noor Rapidograph, Inc. | Tooth whitening cosmetic composition |
US4072551A (en) | 1975-12-15 | 1978-02-07 | Hoffman-La Roche Inc. | Novel dosage form |
US4136145A (en) | 1974-07-05 | 1979-01-23 | Schering Aktiengesellschaft | Medicament carriers in the form of film having active substance incorporated therein |
US4136162A (en) | 1974-07-05 | 1979-01-23 | Schering Aktiengesellschaft | Medicament carriers in the form of film having active substance incorporated therein |
US4138314A (en) | 1975-04-10 | 1979-02-06 | Basf Wyandotte Corporation | Method of forming diaphragms from discrete thermoplastic fibers requiring no bonding or cementing |
US4139627A (en) | 1977-10-06 | 1979-02-13 | Beecham Inc. | Anesthetic lozenges |
US4138814A (en) | 1976-03-08 | 1979-02-13 | Pacemaker Corporation | Disposable dental tray for topical application of fluoride gel and other dental medications |
US4182222A (en) | 1978-02-16 | 1980-01-08 | Stahl Robert L | Coupon confining bag method |
US4211330A (en) | 1979-02-01 | 1980-07-08 | Strock Alvin E | Oral health and hygiene kit |
IE42604B1 (en) | 1974-07-05 | 1980-09-10 | Schering Ag | A pharmaceutical preparation in the form of a foil having an active substance incorporated therein |
US4251400A (en) | 1971-11-03 | 1981-02-17 | Borden, Inc. | Hot and cold water redispersible polyvinyl acetate adhesives |
US4292299A (en) | 1978-11-06 | 1981-09-29 | Teijin Limited | Slow-releasing medical preparation to be administered by adhering to a wet mucous surface |
US4294820A (en) | 1979-08-14 | 1981-10-13 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing phenylephrine |
US4307075A (en) | 1979-09-13 | 1981-12-22 | American Home Products Corporation | Topical treatment of aphthous stomatitis |
US4308250A (en) | 1978-11-07 | 1981-12-29 | Beecham Group Limited | Sustained drug release device |
US4324547A (en) | 1978-09-16 | 1982-04-13 | Vishay Intertechnology, Inc. | Dentistry technique |
US4325855A (en) | 1975-09-10 | 1982-04-20 | Lingner And Fischer Gmbh | Adhesives |
US4331576A (en) | 1981-01-29 | 1982-05-25 | Herman Colon | Water-soluble, pressure-sensitive, hot-melt adhesives |
JPS5728102Y2 (en) | 1976-11-10 | 1982-06-18 | ||
US4335731A (en) | 1978-07-25 | 1982-06-22 | Bora Jr F William | Device for oral hygiene care |
DE2330869C2 (en) | 1973-06-16 | 1982-10-28 | Gerd 6070 Langen Hanel | Articulation or occlusion material |
US4363843A (en) | 1979-03-20 | 1982-12-14 | Raychem Limited | Seals |
US4373036A (en) | 1981-12-21 | 1983-02-08 | Block Drug Company, Inc. | Denture fixative composition |
US4376628A (en) | 1979-05-09 | 1983-03-15 | B.V. Gaba | Device for treating teeth |
GB2115431A (en) | 1982-02-25 | 1983-09-07 | Valleylab Inc | Hydrophilic, elastomeric, pressure-sensitive adhesive |
US4428373A (en) | 1982-02-03 | 1984-01-31 | Sultan Dental Products Limited | Disposable dental tray |
US4431631A (en) | 1983-01-03 | 1984-02-14 | Colgate-Palmolive Company | Aqueous oral solution |
US4438258A (en) | 1981-06-12 | 1984-03-20 | National Research Development Corporation | Hydrogels |
US4442258A (en) | 1979-07-04 | 1984-04-10 | Nitto Electric Industrial Co., Ltd. | Water-soluble pressure-sensitive adhesive composition |
EP0109269A1 (en) | 1982-11-12 | 1984-05-23 | Internationale Verbandstoff-Fabrik Schaffhausen | Shaped semi-solid articles |
US4460562A (en) | 1982-01-06 | 1984-07-17 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing propranolol |
US4503070A (en) | 1981-07-31 | 1985-03-05 | Eby Iii George A | Method for reducing the duration of the common cold |
US4515162A (en) | 1980-03-14 | 1985-05-07 | Nitto Electric Industrial Co., Ltd. | Electrode pad |
US4517173A (en) | 1980-09-26 | 1985-05-14 | Nippon Soda Co. Ltd. | Mucous membrane-adhering film preparation and process for its preparation |
US4518721A (en) | 1982-03-26 | 1985-05-21 | Richardson-Vicks Inc. | Hydrophilic denture adhesive |
US4522805A (en) | 1983-06-08 | 1985-06-11 | Norman Gordon | Tooth and gum dentifrice |
US4522806A (en) | 1980-10-10 | 1985-06-11 | Lever Brothers Company | Oral compositions for hexetidine and zinc salts for the synergistic inhibition of dental plaque |
US4528180A (en) | 1983-03-01 | 1985-07-09 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery thereof |
US4529748A (en) | 1982-08-16 | 1985-07-16 | Richardson Gmbh | Dental prosthesis adhesive |
US4532063A (en) | 1983-08-15 | 1985-07-30 | S. C. Johnson & Son, Inc. | Dissolvable bleach sheet |
US4537778A (en) | 1983-01-03 | 1985-08-27 | Colgate-Palmolive Company | Oral preparation |
GB2108841B (en) | 1981-10-20 | 1985-09-11 | Robert Gething | Sustained release layered pharmaceutical compositions |
US4544354A (en) | 1984-09-21 | 1985-10-01 | Gores Kenneth W | Anteriorly bridged dental trays |
US4554154A (en) | 1983-03-15 | 1985-11-19 | White Maurice J E | Dental product and method of dental treatment |
GB2159052A (en) | 1984-05-18 | 1985-11-27 | Bernard John Roberts | Artificial mucus material |
US4557692A (en) | 1981-02-12 | 1985-12-10 | Chorbajian Peter M | Occlusal splints and the method of manufacturing the same |
US4560351A (en) | 1984-07-05 | 1985-12-24 | Osborne Travis H | Method of and apparatus for applying dental treatment fluid |
US4568536A (en) | 1985-02-08 | 1986-02-04 | Ethicon, Inc. | Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition |
US4593053A (en) | 1984-12-07 | 1986-06-03 | Medtronic, Inc. | Hydrophilic pressure sensitive biomedical adhesive composition |
US4592488A (en) | 1985-05-24 | 1986-06-03 | Simon Gilbert I | Method for the preparation of chemotherapeutic compositions for the treatment of periodontal disease, compositions therefor and use thereof |
US4592487A (en) | 1985-07-03 | 1986-06-03 | Simon Gilbert I | Dentifrices |
CA1209761A (en) | 1982-05-22 | 1986-08-19 | Avraham Fishman | Tooth cleaning device |
US4623394A (en) * | 1984-04-14 | 1986-11-18 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Gradually disintegrable molded article |
JPS61280423A (en) | 1985-06-05 | 1986-12-11 | Kiyuukiyuu Yakuhin Kogyo Kk | Mucosal application agent in oral cavity |
US4650665A (en) | 1985-02-08 | 1987-03-17 | Ethicon, Inc. | Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition |
US4661070A (en) | 1986-03-17 | 1987-04-28 | Joshua Friedman | Method for bleaching discolored teeth |
EP0232006A2 (en) | 1986-01-22 | 1987-08-12 | Imperial Chemical Industries Plc | Compositions for surface treatment, polymers therefor, and method of surface treatment |
US4687663A (en) | 1983-03-01 | 1987-08-18 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery thereof |
US4690996A (en) | 1985-08-28 | 1987-09-01 | National Starch And Chemical Corporation | Inverse emulsions |
US4696757A (en) | 1986-06-16 | 1987-09-29 | American Home Products Corporation | Stable hydrogen peroxide gels |
US4713239A (en) | 1979-05-29 | 1987-12-15 | Vsesojuny Kardiologichesky Nauchny Tsentr Adkaemii Meditsinski Nauk Sssr | Antianginal film and method of treating ischemic heart disease |
US4712460A (en) | 1985-11-18 | 1987-12-15 | Biotrack, Inc. | Integrated drug dosage form and metering system |
US4713243A (en) | 1986-06-16 | 1987-12-15 | Johnson & Johnson Products, Inc. | Bioadhesive extruded film for intra-oral drug delivery and process |
EP0252459A1 (en) | 1986-07-07 | 1988-01-13 | Schering Corporation | Compartmentalized transdermal delivery system |
US4722761A (en) | 1986-03-28 | 1988-02-02 | Baxter Travenol Laboratories, Inc. | Method of making a medical electrode |
US4728291A (en) | 1986-06-26 | 1988-03-01 | Golub Jeff E | Cloth wrap dental process |
US4741700A (en) | 1986-07-16 | 1988-05-03 | Barabe David J | Dental breath freshening device |
US4741941A (en) | 1985-11-04 | 1988-05-03 | Kimberly-Clark Corporation | Nonwoven web with projections |
US4755386A (en) | 1986-01-22 | 1988-07-05 | Schering Corporation | Buccal formulation |
US4755385A (en) | 1985-07-10 | 1988-07-05 | Dr. Karl Thomae, Gmbh | Oral pharmaceutical preparations containing 9-deoxo-11-deoxy-9,11-[imino[2-(2-methoxyethoxy)-ethylidene]-oxy]-(9S)-erythromycin |
EP0273069A1 (en) | 1986-12-30 | 1988-07-06 | Uni Colloid Kabushiki Kaisha | Glucomannan/polyhydric alcohol composition and film prepared therefrom |
US4770634A (en) | 1986-06-11 | 1988-09-13 | Pellico Michael A | Method for treating teeth with foamable fluoride compositions |
US4772470A (en) | 1985-04-27 | 1988-09-20 | Nitto Electric Industrial Co., Ltd. | Oral bandage and oral preparations |
US4777046A (en) | 1984-10-04 | 1988-10-11 | Nippon Kayaku Kabushiki Kaisha | Sheet-like preparation |
EP0288420A1 (en) | 1987-04-17 | 1988-10-26 | Colgate-Palmolive Company | Stable hydrogen peroxide dental gel |
US4786253A (en) | 1986-12-04 | 1988-11-22 | Henneret Properties (Proprietary) Limited | Dental model articulator |
US4788052A (en) | 1987-04-17 | 1988-11-29 | Colgate-Palmolive Company | Stable hydrogen peroxide dental gel containing fumed silicas |
US4799888A (en) | 1986-06-26 | 1989-01-24 | Golub Jeff E | Dental process with treated fabric |
US4812308A (en) | 1987-02-20 | 1989-03-14 | Church & Dwight Co., Inc. | Hydrogen peroxide-releasing tooth powder |
US4837008A (en) | 1985-04-09 | 1989-06-06 | Peroxydent Group | Periodontal composition and method |
US4839157A (en) | 1987-04-17 | 1989-06-13 | Colgate-Palmolive Company | Stable hydrogen peroxide dental gel containing fumed silicas |
US4842854A (en) * | 1979-05-29 | 1989-06-27 | Vsesojuzny Kardiologichesky Nauchny Tsentr Akademii Meditsinskiki Nauk Ssr | Antianginal plate for treating ischemic heart disease |
US4849213A (en) | 1983-03-01 | 1989-07-18 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery therof |
US4849246A (en) | 1985-10-09 | 1989-07-18 | Wolfgang Schmidt | Process for producing an administration or dosage form for drugs, reagents or other active ingredients |
EP0328317A1 (en) | 1988-02-04 | 1989-08-16 | Takeda Chemical Industries, Ltd. | Edible films |
US4860754A (en) | 1987-04-01 | 1989-08-29 | E. R. Squibb & Sons, Inc. | Electrically conductive adhesive materials |
US4876092A (en) | 1986-02-01 | 1989-10-24 | Teikoku Seiyaku Kabushiki Kaisha | Sheet-shaped adhesive preparation applicable to oral cavity |
JPH01279838A (en) | 1988-04-30 | 1989-11-10 | Kiyuukiyuu Yakuhin Kogyo Kk | Lysozyme chloride-containing plaster for gingivitis and pyorrhea |
US4891400A (en) * | 1985-09-13 | 1990-01-02 | Bayer Aktiengesellschaft | Silicone molding compounds |
US4895721A (en) | 1988-01-22 | 1990-01-23 | Carter-Wallace Inc. | Peroxide gel dentifrice compositions |
US4900552A (en) | 1988-03-30 | 1990-02-13 | Watson Laboratories, Inc. | Mucoadhesive buccal dosage forms |
US4900554A (en) | 1986-12-24 | 1990-02-13 | Teikoku Seiyaku Co., Ltd. | Adhesive device for application to body tissue |
US4902227A (en) | 1988-05-04 | 1990-02-20 | Pascal Company, Inc. | Dental treatment tray |
US4910247A (en) | 1989-03-27 | 1990-03-20 | Gaf Chemicals Corporation | Adhesive composition |
FR2637175A1 (en) | 1988-10-03 | 1990-04-06 | Gaillard Eric | Tape for interdental cleaning |
US4915950A (en) | 1988-02-12 | 1990-04-10 | Cygnus Research Corporation | Printed transdermal drug delivery device |
US4919615A (en) | 1989-04-28 | 1990-04-24 | Croll Theodore P | Orthodontic band cap |
US4925670A (en) | 1986-09-09 | 1990-05-15 | Desitin Arzneimittel Gmbh | Administration and dosage form for drug active agents, reagents or the like and process for the preparation thereof |
US4927636A (en) | 1986-11-11 | 1990-05-22 | 501 Kabushiki Kaisha Hayashibara Kagaku Kenkyujo | Association complex comprising pullulan and polyethylene glycol, and preparation and uses of the same |
US4927634A (en) | 1987-12-16 | 1990-05-22 | Richardson-Vicks Inc. | Pharmaceutical compositions containing dyclonine HC1 and phenol |
US4931282A (en) | 1987-11-25 | 1990-06-05 | Minnesota Mining And Manufacturing Company | Pressure-sensitive medical sealant |
US4948580A (en) | 1988-12-08 | 1990-08-14 | E. R. Squibb & Sons, Inc. | Muco-bioadhesive composition |
US4968251A (en) | 1989-07-03 | 1990-11-06 | Darnell Daniel H | Treatment of a tooth |
US4971782A (en) | 1983-09-14 | 1990-11-20 | Peroxydent Group | Periodontal composition and method |
US4972946A (en) | 1990-01-08 | 1990-11-27 | Dale Whittaker | Disposable dental hygiene kit |
US4978531A (en) | 1987-08-13 | 1990-12-18 | Fordonal, S.A. | Clebopride transdermal patch |
US4980152A (en) | 1987-08-06 | 1990-12-25 | Marion Laboratories | Oral preparation |
US4983379A (en) | 1983-03-01 | 1991-01-08 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery thereof |
US4983381A (en) | 1985-12-30 | 1991-01-08 | Futura Medical S.A. | Method and device for producing the whitening of live teeth with pathological and normal colorations |
US4988500A (en) | 1989-09-29 | 1991-01-29 | The Procter & Gamble Company | Oral compositions |
US4990089A (en) | 1988-08-23 | 1991-02-05 | Dunhall Pharmaceuticals, Inc. | Method and material for brightening teeth |
US5001170A (en) | 1989-12-01 | 1991-03-19 | Warner-Lambert Company | Denture stabilizer |
WO1991006289A1 (en) | 1989-10-31 | 1991-05-16 | Watson Laboratories, Inc. | Mucoadhesive carrier for delivery of therapeutical agent |
US5024701A (en) | 1983-08-01 | 1991-06-18 | Hercules Incorporated | Denture adhesive composition |
US5047244A (en) | 1988-06-03 | 1991-09-10 | Watson Laboratories, Inc. | Mucoadhesive carrier for delivery of therapeutical agent |
US5059417A (en) | 1990-06-26 | 1991-10-22 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Peroxide gel dentifrice |
WO1991016041A1 (en) | 1990-04-26 | 1991-10-31 | Smith Kline & French Laboratories Limited | Pharmaceutical compositions |
US5064717A (en) | 1989-04-28 | 1991-11-12 | Kanzaki Paper Manufacturing Co., Ltd. | Adhesive sheet |
JPH03264523A (en) | 1990-03-13 | 1991-11-25 | Sekisui Chem Co Ltd | Bandage for application in oral cavity |
JPH03264522A (en) | 1990-03-13 | 1991-11-25 | Sekisui Chem Co Ltd | Bandage for application in oral cavity |
US5076791A (en) | 1990-10-22 | 1991-12-31 | Madray Jr George | Professional home method for bleaching teeth |
US5084268A (en) | 1991-06-17 | 1992-01-28 | Dental Concepts, Inc. | Tooth whitening dentifrice |
US5098303A (en) | 1990-03-22 | 1992-03-24 | Ultradent Products, Inc. | Method for bleaching teeth |
US5122365A (en) | 1989-02-15 | 1992-06-16 | Natural White, Inc. | Teeth whitener |
US5158825A (en) | 1989-07-13 | 1992-10-27 | Oskar Altwirth | Adherent insert for artificial teeth and process of manufacturing the insert |
US5160737A (en) | 1988-05-03 | 1992-11-03 | Perio Products Ltd. | Liquid polymer composition, and method of use |
US5165424A (en) * | 1990-08-09 | 1992-11-24 | Silverman Harvey N | Method and system for whitening teeth |
US5166233A (en) | 1989-01-31 | 1992-11-24 | Nitto Denko Corporation | Film applicable to oral mucosa and drug preparation comprising the same |
US5171564A (en) | 1991-09-13 | 1992-12-15 | Colgate-Palmolive | Aqueous tooth whitening dentifrice |
US5186938A (en) | 1984-07-24 | 1993-02-16 | Key Pharmaceuticals, Inc. | Adhesive transdermal dosage layer |
US5192802A (en) | 1991-09-25 | 1993-03-09 | Mcneil-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
USRE34196E (en) | 1988-08-23 | 1993-03-16 | Dunhall Pharmaceuticals, Inc. | Method and material for brightening teeth |
US5197331A (en) * | 1987-12-30 | 1993-03-30 | Yazaki Corporation | Oscillatory angular speed detecting apparatus |
EP0539751A1 (en) | 1991-10-28 | 1993-05-05 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
US5211559A (en) | 1991-07-18 | 1993-05-18 | Gillette Canada Inc. | Dental treatment tray for holding medicament gel |
JPH05124954A (en) | 1991-10-29 | 1993-05-21 | Mitsubishi Kasei Corp | Sheetlike solid medicinal composition |
US5229164A (en) | 1985-12-19 | 1993-07-20 | Capsoid Pharma Gmbh | Process for producing individually dosed administration forms |
US5234342A (en) | 1990-03-22 | 1993-08-10 | Ultradent Products, Inc. | Sustained release method for treating teeth surfaces |
JPH05236885A (en) | 1991-07-17 | 1993-09-17 | Tazawa Toshihiko | Flavoring and refreshing food formed into film |
US5252334A (en) | 1989-09-08 | 1993-10-12 | Cygnus Therapeutic Systems | Solid matrix system for transdermal drug delivery |
CA2078960A1 (en) | 1992-04-21 | 1993-10-22 | John Wick | Hydrogel applicator and methods of making same |
US5256402A (en) | 1991-09-13 | 1993-10-26 | Colgate-Palmolive Company | Abrasive tooth whitening dentifrice of improved stability |
EP0569797A2 (en) | 1992-05-04 | 1993-11-18 | Digestive Care Inc. | Intraoral device for slow medicament release |
US5271940A (en) | 1989-09-14 | 1993-12-21 | Cygnus Therapeutic Systems | Transdermal delivery device having delayed onset |
US5288498A (en) | 1985-05-01 | 1994-02-22 | University Of Utah Research Foundation | Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments |
US5290566A (en) | 1990-12-18 | 1994-03-01 | Schow Robert S | Tooth whitening formulation and method |
US5310563A (en) | 1991-10-25 | 1994-05-10 | Colgate-Palmolive Company | Dental material and method for applying preventative and therapeutic agents |
EP0599435A1 (en) | 1992-11-19 | 1994-06-01 | Colgate-Palmolive Company | Oral composition having improved tooth whitening effect |
US5326685A (en) | 1991-02-13 | 1994-07-05 | Gaglio Thomas J | Viscous fluid dispensing apparatus |
US5330746A (en) | 1988-05-03 | 1994-07-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Dental varnish composition, and method of use |
US5332576A (en) | 1991-02-27 | 1994-07-26 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
US5340581A (en) | 1991-08-23 | 1994-08-23 | Gillette Canada, Inc. | Sustained-release matrices for dental application |
US5340314A (en) | 1992-11-27 | 1994-08-23 | Tarvis Jo Ellen | Method of bonding and relining dentures |
EP0381194B1 (en) | 1989-01-31 | 1994-08-31 | Nitto Denko Corporation | Drug preparation applicable to oral mucosa |
US5344702A (en) | 1990-09-14 | 1994-09-06 | Hoechst Celanese Corp. | Coated fibers |
US5354551A (en) | 1989-10-14 | 1994-10-11 | Desitin Arzneimittel Gmbh | Oral and dental hygiene preparation |
US5356291A (en) | 1989-07-03 | 1994-10-18 | Dunhall Pharmaceuticals, Inc. | Treatment of a tooth |
US5376006A (en) | 1990-03-22 | 1994-12-27 | Ultradent Products, Inc. | Dental bleaching compositions and methods for bleaching teeth surfaces |
US5380198A (en) | 1990-08-06 | 1995-01-10 | Suhonen; Jouko | Matrix for dental medicine and a device for the fabricaton of matrix bands |
EP0636378A1 (en) | 1993-07-28 | 1995-02-01 | JOHNSON & JOHNSON MEDICAL, INC. | Absorbable composite materials for use in the treatment of periodontal disease |
EP0637446A1 (en) | 1993-06-08 | 1995-02-08 | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. | Dental floss provided with chemotherapy agents |
US5393528A (en) | 1992-05-07 | 1995-02-28 | Staab; Robert J. | Dissolvable device for contraception or delivery of medication |
US5401495A (en) | 1990-10-10 | 1995-03-28 | Natural White, Inc. | Teeth whitener |
US5401528A (en) * | 1991-03-19 | 1995-03-28 | Thera Patent GmbH & Co. KG Geselleschaft fur industrielle Schutzrechte | Use of compositions based on organically modified silicic acid polycondensates for coating teeth and dental prostheses |
US5425953A (en) * | 1991-04-23 | 1995-06-20 | Perio Products Limited | Polymer composition for tooth bleaching and other dental uses thereof |
US5427770A (en) * | 1988-11-28 | 1995-06-27 | Chesebrough-Ponds Usa Co., Division Of Conopco, Inc. | Dentifrices containing amino alkyl silicones |
CA2095445A1 (en) | 1994-01-10 | 1995-07-11 | Howard Rocket | Index dental tooth cleanser |
US5438076A (en) * | 1988-05-03 | 1995-08-01 | Perio Products, Ltd. | Liquid polymer composition, and method of use |
CA2000040C (en) | 1987-08-07 | 1995-10-03 | Skip Berg | Disposable tooth cleaning and polishing apparatus |
US5455043A (en) | 1990-06-13 | 1995-10-03 | Fischel-Ghodsian; Fariba | Device for controlled release of vaporous medications through nasal route |
JPH07100186B2 (en) | 1989-02-10 | 1995-11-01 | 日産自動車株式会社 | Method and apparatus for manufacturing constant velocity joint outer ring |
US5472704A (en) | 1991-05-30 | 1995-12-05 | Recordati S.A., Chemical And Pharmaceutical Company | Pharmaceutical controlled-release composition with bioadhesive properties |
US5474780A (en) | 1990-04-27 | 1995-12-12 | Allergan, Inc. | Monolithic maleic anhydride drug delivery systems |
US5505933A (en) | 1994-06-27 | 1996-04-09 | Colgate Palmolive Company | Desensitizing anti-tartar dentifrice |
CA2162885A1 (en) | 1994-11-14 | 1996-05-15 | Donald P. Hsu | Stabilized dentifrice compositions containing reactive ingredients |
US5522726A (en) | 1994-10-27 | 1996-06-04 | Hodosh; Milton | Method for anesthetizing teeth |
US5560379A (en) | 1994-08-12 | 1996-10-01 | Pieczenik; George | Dental paper pick and flosser |
US5565190A (en) | 1994-11-14 | 1996-10-15 | Colgate Palmolive Company | Dentifrice compositions containing reactive ingredients stabilized with alkali metal compounds |
US5575654A (en) | 1992-11-24 | 1996-11-19 | Fontenot; Mark G. | Apparatus and method for lightening teeth |
US5579523A (en) * | 1992-10-13 | 1996-11-26 | Sony Corporation | Method for controlled locking/unlocking of a system using a locking mode flag during an interrupt routine |
JPH08325128A (en) | 1995-03-31 | 1996-12-10 | Sunstar Inc | Long term sustainable base for oral cavity and composition using the same |
US5593684A (en) | 1993-08-04 | 1997-01-14 | Pharmacia Ab | Method and therapeutic system for smoking cessation |
US5599553A (en) | 1992-09-01 | 1997-02-04 | Dong Kook Pharmaceutical Co., Ltd. | Local drug delivery film for periodontal treatment |
US5611687A (en) | 1995-11-06 | 1997-03-18 | Dental Concepts Inc. | Oral hygiene delivery system |
EP0763358A1 (en) | 1995-09-12 | 1997-03-19 | Bristol-Myers Squibb Company | Buccal delivery system for therapeutic agents |
US5613942A (en) * | 1994-10-04 | 1997-03-25 | Minnesota Mining And Manufacturing Company | Adhesive sheet material suitable for use on wet surfaces |
RU2075965C1 (en) | 1994-09-29 | 1997-03-27 | Гарник Алексанович Чухаджян | Agent for mouth cavity illness treatment |
US5620757A (en) * | 1989-05-23 | 1997-04-15 | Mitsubishi Rayon Co., Ltd. | Edible film and method of making same |
US5620322A (en) | 1995-07-27 | 1997-04-15 | Lococo; Michael | Dental matrix strip |
US5626866A (en) | 1994-03-07 | 1997-05-06 | Theratech, Inc. | Drug-containing adhesive composite transdermal delivery device |
US5629003A (en) | 1990-06-07 | 1997-05-13 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Rapidly disintegrating sheet-like presentations of multiple dosage units |
US5631000A (en) | 1996-03-11 | 1997-05-20 | Laclede Professional Products, Inc. | Anhydrous tooth whitening gel |
US5660178A (en) | 1992-12-01 | 1997-08-26 | Minnesota Mining And Manufacturing Company | Hydrophilic pressure sensitive adhesives |
US5662758A (en) | 1996-01-10 | 1997-09-02 | The Procter & Gamble Company | Composite material releasably sealable to a target surface when pressed thereagainst and method of making |
US5678273A (en) | 1996-03-20 | 1997-10-21 | Porcelli; V. Lorenzo | Disposable oral hygiene applicator |
US5700478A (en) | 1993-08-19 | 1997-12-23 | Cygnus, Inc. | Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavity |
US5707736A (en) | 1991-04-04 | 1998-01-13 | Sion Texo Medic Ltd. | Products having anti-microbial activity |
US5707235A (en) | 1995-04-03 | 1998-01-13 | Knutson; Eric J. | Dental tray spacer |
JPH1017448A (en) | 1996-06-28 | 1998-01-20 | Lion Corp | Plaster for oral cavity |
JPH1026639A (en) | 1996-07-11 | 1998-01-27 | Hitachi Ltd | Current sensor and electric device housing current sensor |
US5713738A (en) | 1995-12-12 | 1998-02-03 | Britesmile, Inc. | Method for whitening teeth |
US5723132A (en) | 1991-08-23 | 1998-03-03 | Gillette Canada Inc. | Sustained-release matrices for dental application |
US5766011A (en) | 1996-11-27 | 1998-06-16 | Sibner; Jeffrey A. | Dental bleaching composition and method |
US5780045A (en) | 1992-05-18 | 1998-07-14 | Minnesota Mining And Manufacturing Company | Transmucosal drug delivery device |
US5800832A (en) * | 1996-10-18 | 1998-09-01 | Virotex Corporation | Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces |
US5819765A (en) | 1994-05-11 | 1998-10-13 | Mittiga; Maria Ida | Finger glove comprising areas prepared for oral hygiene |
US5827591A (en) | 1996-10-08 | 1998-10-27 | Tricor Direct, Inc. | Removable adhesive notes for an industrial setting |
WO1998055079A2 (en) * | 1997-06-06 | 1998-12-10 | The Procter & Gamble Company | A delivery system for an oral care substance using a strip of material having low flexural stiffness |
US5851512A (en) | 1990-03-22 | 1998-12-22 | Ultradent Products, Inc. | Dental compositions having a sticky matrix material for treating sensitive teeth |
US5856282A (en) * | 1994-12-22 | 1999-01-05 | The Procter & Gamble Company | Silicone compositions |
US5855870A (en) | 1990-03-22 | 1999-01-05 | Ultradent Products, Inc. | Method for treating sensitive teeth |
US5858332A (en) | 1997-01-10 | 1999-01-12 | Ultradent Products, Inc. | Dental bleaching compositions with high concentrations of hydrogen peroxide |
US5879691A (en) | 1997-06-06 | 1999-03-09 | The Procter & Gamble Company | Delivery system for a tooth whitener using a strip of material having low flexural stiffness |
US5894017A (en) | 1997-06-06 | 1999-04-13 | The Procter & Gamble Company | Delivery system for an oral care substance using a strip of material having low flexural stiffness |
US5922307A (en) | 1995-09-25 | 1999-07-13 | R. Eric Montgomery | Tooth bleaching compositions |
US5948430A (en) | 1996-11-11 | 1999-09-07 | Lts Lohmann Therapie-Systeme Gmbh | Water soluble film for oral administration with instant wettability |
US5953885A (en) | 1997-04-08 | 1999-09-21 | Retail Communications Corp. | Cosmetic sampler and method of making using bulk thin film application techniques |
US5968633A (en) | 1997-06-06 | 1999-10-19 | The Procter & Gamble Company | Selectively-activatible sheet material for dispensing and dispersing a substance onto a target surface |
US5980249A (en) | 1992-11-24 | 1999-11-09 | Folh, Llc | Method and device for treatment of dentition |
US5985249A (en) | 1990-03-22 | 1999-11-16 | Ultradent Products, Inc. | Sticky dental compositions for adhering a passive-type dental tray over a person's teeth |
US5989569A (en) | 1997-06-06 | 1999-11-23 | The Procter & Gamble Company | Delivery system for a tooth whitener using a permanently deformable strip of material |
WO1999062472A1 (en) * | 1998-06-03 | 1999-12-09 | Wolf Robert O | System for whitening teeth surfaces |
US6008171A (en) * | 1994-12-22 | 1999-12-28 | The Procter & Gamble Company | Cleansing compositions |
WO1999066870A1 (en) | 1998-06-25 | 1999-12-29 | Lavipharm Laboratories, Inc. | A device and method for the treatment of erectile dysfunction |
US6019962A (en) * | 1995-11-07 | 2000-02-01 | The Procter & Gamble Co. | Compositions and methods for improving cosmetic products |
US6024891A (en) * | 1994-12-22 | 2000-02-15 | The Procter & Gamble Company | Silicone compositions |
US6036943A (en) | 1990-03-22 | 2000-03-14 | Ultradent Products, Inc. | Methods for treating a person's teeth using sticky dental compositions in combination with passive-type dental trays |
US6045811A (en) | 1997-06-06 | 2000-04-04 | The Procter & Gamble Company | Delivery system for an oral care substance using a permanently deformable strip of material |
US6071503A (en) * | 1995-11-07 | 2000-06-06 | The Procter & Gamble Company | Transfer resistant cosmetic compositions |
US6072100A (en) | 1998-01-28 | 2000-06-06 | Johnson & Johnson Consumer Products, Inc. | Extrudable compositions for topical or transdermal drug delivery |
US6083421A (en) * | 1996-01-19 | 2000-07-04 | Huang; Lizi | Film coating composition for whitening teeth |
US6090401A (en) | 1999-03-31 | 2000-07-18 | Mcneil-Ppc, Inc. | Stable foam composition |
US6096328A (en) | 1997-06-06 | 2000-08-01 | The Procter & Gamble Company | Delivery system for an oral care substance using a strip of material having low flexural stiffness |
US6094889A (en) | 1997-02-25 | 2000-08-01 | Exxon Chemical Patents, Inc. | Method of form and seal packaging |
US6123950A (en) * | 1994-12-22 | 2000-09-26 | The Procter & Gamble Company | Silicone compositions |
US6129929A (en) * | 1998-10-30 | 2000-10-10 | Noven Pharmaceuticals, Inc. | Patch applicator |
WO2000042992A3 (en) | 1999-01-21 | 2000-10-19 | Lavipharm Lab Inc | Compositions and methods for mucosal delivery |
US6139823A (en) * | 1995-11-07 | 2000-10-31 | The Procter & Gamble Company | Transfer resistant cosmetic compositions |
WO2001001958A1 (en) | 1999-07-02 | 2001-01-11 | The Procter & Gamble Company | Delivery system for oral care compositions comprising organosiloxane reins using a removable backing strip |
US6197331B1 (en) | 1997-07-24 | 2001-03-06 | Perio Products Ltd. | Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity |
US6210699B1 (en) | 1999-04-01 | 2001-04-03 | Watson Pharmaceuticals, Inc. | Oral transmucosal delivery of drugs or any other ingredients via the inner buccal cavity |
US6231957B1 (en) | 1999-05-06 | 2001-05-15 | Horst G. Zerbe | Rapidly disintegrating flavor wafer for flavor enrichment |
JP3198754B2 (en) | 1993-10-04 | 2001-08-13 | 日産自動車株式会社 | Graphic instruction receiving device for CAD system |
US6277458B1 (en) | 1999-03-15 | 2001-08-21 | The Procter & Gamble Company | Release strip with partible break to facilitate |
US20010022964A1 (en) | 1998-09-25 | 2001-09-20 | Leung Sau-Hung S. | Fast dissolving orally consumable films |
US6306370B1 (en) | 1997-05-30 | 2001-10-23 | Ultradent Products, Inc. | Compositions and methods for whitening and desensitizing teeth |
US6309625B1 (en) | 1998-11-12 | 2001-10-30 | Ultradent Products, Inc. | One-part dental compositions and methods for bleaching and desensitizing teeth |
EP1153594A2 (en) | 2000-04-21 | 2001-11-14 | Coden Co., Ltd. | Cosmetic coating composition, especially for teeth, remover, and intraoral lip supporter |
US6322360B1 (en) | 1999-10-22 | 2001-11-27 | 3M Innovative Properties Company | Medication retention assembly for oral delivery tray |
US6337086B1 (en) * | 1999-02-06 | 2002-01-08 | Dow Corning Corporation | Pressure sensitive adhesive compositions for transdermal drug delivery devices |
WO2002002085A2 (en) | 2000-07-04 | 2002-01-10 | Lts Lohmann Therapie-Systeme Ag | Rapidly-decomposing administrable form for releasing active ingredients in the oral cavity or in bodily cavities |
WO2002026196A1 (en) | 2000-09-26 | 2002-04-04 | Patacca Thomas R | Tooth coating composition |
US6375963B1 (en) | 1999-06-16 | 2002-04-23 | Michael A. Repka | Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation thereof |
US6379654B1 (en) | 2000-10-27 | 2002-04-30 | Colgate Palmolive Company | Oral composition providing enhanced tooth stain removal |
WO2002043657A2 (en) | 2000-11-30 | 2002-06-06 | Wm. Wrigley Jr. Company | Improved pullulan free edible film compositions and methods of making the same |
US6406683B1 (en) * | 1995-11-07 | 2002-06-18 | The Procter & Gamble Company | Transfer resistant cosmetic compositions |
US6419906B1 (en) | 2001-03-12 | 2002-07-16 | Colgate Palmolive Company | Strip for whitening tooth surfaces |
US6419903B1 (en) | 2001-08-20 | 2002-07-16 | Colgate Palmolive Company | Breath freshening film |
US20020127254A1 (en) | 1998-06-25 | 2002-09-12 | Lavipharm Laboratories Inc. | Devices for local and systemic delivery of active substance and methods of manufacturing thereof |
US6461158B1 (en) | 2000-08-14 | 2002-10-08 | The Procter & Gamble Company | Products and methods that simulate changes in tooth color |
WO2002092049A2 (en) | 2001-05-14 | 2002-11-21 | 3M Innovative Properties Company | System for delivering cosmetics and pharmaceuticals |
US6500408B2 (en) | 2001-01-27 | 2002-12-31 | Jc Technologies, Inc. | Enamel-safe tooth bleach and method for use |
US6514483B2 (en) | 2001-03-12 | 2003-02-04 | Colgate Palmolive Company | Strip for whitening tooth surfaces |
US6517350B2 (en) | 2000-05-26 | 2003-02-11 | Dentovations Inc. | Method for whitening teeth |
WO2003011259A1 (en) | 2001-07-30 | 2003-02-13 | Wm. Wrigley Jr. Company | Improved edible film formulations containing maltodextrin |
US20030035841A1 (en) | 2001-07-30 | 2003-02-20 | Dzija Michael R. | Edible film formulations containing maltodextrin |
US6537565B2 (en) | 1998-07-07 | 2003-03-25 | Atrix Laboratories, Inc. | Filamentous porous films and methods for producing the same |
JP2003137756A (en) | 2001-11-06 | 2003-05-14 | Kenji Nakamura | Patch for bleaching tooth |
US20030099690A1 (en) | 1997-10-08 | 2003-05-29 | Tsutomu Awamura | Rapidly soluble film preparation |
WO2003043659A1 (en) | 2001-11-16 | 2003-05-30 | Givaudan Sa | Edible film |
US6582708B1 (en) * | 2000-06-28 | 2003-06-24 | The Procter & Gamble Company | Tooth whitening substance |
US20030152528A1 (en) | 2001-05-01 | 2003-08-14 | Parminder Singh | Hydrogel compositions for tooth whitening |
US20030170308A1 (en) | 2001-05-01 | 2003-09-11 | Cleary Gary W. | Hydrogel compositions |
US20030194382A1 (en) | 2001-06-23 | 2003-10-16 | Sug-Youn Chang | Multi-layer patches for teeth whitening |
US20030219390A1 (en) | 2002-05-24 | 2003-11-27 | Santarpia R. Peter | Liquid tooth whitening composition |
US20030228264A1 (en) | 2002-06-06 | 2003-12-11 | Perna Salvatore F. | Dissolvable teeth whitening apparatus |
US6669930B1 (en) | 2003-01-15 | 2003-12-30 | Colgate Palmolive Company | Liquid tooth whitening gel |
US6673361B1 (en) | 1999-05-19 | 2004-01-06 | Nof Corporation | Polymer, in vivo degradable material, and use |
US6682721B2 (en) | 2000-03-17 | 2004-01-27 | Lg Household & Healthcare Ltd. | Patches for teeth whitening |
US6682756B1 (en) | 1996-12-16 | 2004-01-27 | Lts Lohmann Therapie-Systeme Ag | Individually dosed foil-form presentation which decomposes rapidly on contact with liquid and contains an active substance, in particular an aromatic substance |
US20040022755A1 (en) | 2002-08-02 | 2004-02-05 | Satish Kamath | Polyacrylic film forming compositions |
US6689344B2 (en) | 2000-03-17 | 2004-02-10 | Lg Household & Healthcare Ltd. | Patches for teeth whitening |
US20040043134A1 (en) | 2002-08-27 | 2004-03-04 | Corriveau Christine Leclair | Rolled edible thin film products and methods of making same |
US6703040B2 (en) | 2000-01-11 | 2004-03-09 | Intralytix, Inc. | Polymer blends as biodegradable matrices for preparing biocomposites |
US20040062724A1 (en) | 2001-08-16 | 2004-04-01 | Moro Daniel G. | Erodible film for treating the surfaces of teeth |
US6719995B2 (en) | 2001-03-19 | 2004-04-13 | The Procter & Gamble Company | Systems for delivering a cosmetic and/or therapeutic active to oral surfaces using an integral carrier |
US20040086468A1 (en) | 2002-10-30 | 2004-05-06 | Isp Investments Inc. | Delivery system for a tooth whitener |
US20040091432A1 (en) | 2002-11-04 | 2004-05-13 | Dulin Jacques M. | Oral hygiene system and method of treatment |
US6737080B1 (en) | 1999-06-04 | 2004-05-18 | Lts Lohmann Therapie-Systeme Ag | Composite laminate and method for its production |
US20040096569A1 (en) | 2002-11-15 | 2004-05-20 | Barkalow David G. | Edible film products and methods of making same |
US20040105834A1 (en) | 2001-05-01 | 2004-06-03 | Corium International | Hydrogel compositions with an erodible backing member |
US20040136927A1 (en) | 2000-03-17 | 2004-07-15 | Ji-Young Kim | Apparatus and method for whitening teeth |
US20050048102A1 (en) | 1997-10-16 | 2005-03-03 | Virotex Corporation | Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces |
CA2162536C (en) | 1994-11-14 | 2007-12-04 | Donald P. Hsu | Dentifrice compositions having improved anticalculus properties |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4950479A (en) * | 1986-11-06 | 1990-08-21 | Hill Ira D | Method of interrupting the formation of plaque |
US5032387A (en) * | 1986-11-06 | 1991-07-16 | Princeton Pharmaceutical Inc. | Dental and oral hygiene preparations |
US5009881A (en) * | 1986-11-06 | 1991-04-23 | Hill Ira D | Oral hygiene gels |
US5888491A (en) * | 1993-12-06 | 1999-03-30 | Minnesota Mining And Manufacturing Company | Optionally crosslinkable coatings, compositions and methods of use |
US5651959A (en) * | 1995-06-05 | 1997-07-29 | Whitehill Oral Technologies, Inc. | Ultramulsion based oral care compositions |
-
2000
- 2000-06-30 DE DE60002471T patent/DE60002471T2/en not_active Expired - Lifetime
- 2000-06-30 WO PCT/US2000/018189 patent/WO2001001942A1/en active IP Right Grant
- 2000-06-30 EP EP00945084A patent/EP1200064B1/en not_active Expired - Lifetime
- 2000-06-30 AU AU59075/00A patent/AU5907500A/en not_active Abandoned
- 2000-06-30 JP JP2001507453A patent/JP3927030B2/en not_active Expired - Lifetime
- 2000-06-30 AU AU59074/00A patent/AU768471B2/en not_active Ceased
- 2000-06-30 KR KR1020027000033A patent/KR20020032521A/en not_active Application Discontinuation
- 2000-06-30 AT AT00945085T patent/ATE285220T1/en not_active IP Right Cessation
- 2000-06-30 AT AT00945084T patent/ATE238766T1/en not_active IP Right Cessation
- 2000-06-30 AU AU59073/00A patent/AU5907300A/en not_active Abandoned
- 2000-06-30 PL PL357159A patent/PL200936B1/en not_active IP Right Cessation
- 2000-06-30 EP EP00945085A patent/EP1196137B1/en not_active Expired - Lifetime
- 2000-06-30 CN CNB008099847A patent/CN1204875C/en not_active Expired - Fee Related
- 2000-06-30 CA CA002373983A patent/CA2373983C/en not_active Expired - Fee Related
- 2000-06-30 HU HU0201620A patent/HUP0201620A3/en unknown
- 2000-06-30 BR BR0012145-2A patent/BR0012145A/en not_active IP Right Cessation
- 2000-06-30 CZ CZ20014709A patent/CZ20014709A3/en unknown
- 2000-06-30 US US10/927,655 patent/USRE42126E1/en not_active Expired - Fee Related
- 2000-06-30 ES ES00945084T patent/ES2199168T3/en not_active Expired - Lifetime
- 2000-06-30 MX MXPA02000262A patent/MXPA02000262A/en active IP Right Grant
- 2000-06-30 RU RU2002102710/15A patent/RU2223746C2/en not_active IP Right Cessation
- 2000-06-30 DE DE60016927T patent/DE60016927T2/en not_active Expired - Lifetime
- 2000-06-30 CA CA002375093A patent/CA2375093C/en not_active Expired - Fee Related
- 2000-06-30 WO PCT/US2000/018187 patent/WO2001001941A1/en active Application Filing
- 2000-06-30 SK SK1941-2001A patent/SK19412001A3/en unknown
- 2000-06-30 WO PCT/US2000/018188 patent/WO2001001958A1/en not_active Application Discontinuation
-
2001
- 2001-12-24 IL IL147265A patent/IL147265A/en not_active IP Right Cessation
-
2002
- 2002-01-02 MA MA26459A patent/MA25681A1/en unknown
- 2002-01-02 NO NO20020004A patent/NO20020004L/en not_active IP Right Cessation
- 2002-09-27 HK HK02107161.6A patent/HK1047035B/en not_active IP Right Cessation
Patent Citations (370)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA681997A (en) | 1964-03-10 | Minnesota Mining And Manufacturing Company | Extrudable polypyrrolidone compositions | |
US2835628A (en) | 1957-04-01 | 1958-05-20 | Jacob A Saffir | Means for treating teeth |
DE1104116B (en) | 1959-02-05 | 1961-04-06 | Dr Rudolf Eisenhut | Auxiliary strips to hold the filling when sealing teeth |
US3070102A (en) | 1960-05-12 | 1962-12-25 | Harold B Macdonald | Throw-away toothbrush and package |
US3096202A (en) | 1960-08-30 | 1963-07-02 | Johnson & Johnson | Polyvinyl pyrrolidone pressure sensitive adhestive and tape containing same |
US3444858A (en) | 1965-05-14 | 1969-05-20 | Higham S Russell | Method and means for administering drugs |
GB1142325A (en) | 1965-05-14 | 1969-02-05 | Higham Stanley Russell | Means for administering drugs |
GB1240411A (en) | 1968-05-31 | 1971-07-21 | Gerhard Weinz | Pharmaceutically treated tab for application to the mucous membrane of a living organism |
US3998215A (en) | 1968-12-18 | 1976-12-21 | Minnesota Mining And Manufacturing Company | Bio-medical electrode conductive gel pads |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3657413A (en) | 1969-08-28 | 1972-04-18 | Block Drug Co | Antiseptic composition containing peroxide glycerol and carboxypolymethylene polymer |
US3640741A (en) | 1970-02-24 | 1972-02-08 | Hollister Inc | Composition containing gel |
US3625215A (en) | 1970-07-09 | 1971-12-07 | Sverre Quisling | Dental sheaths |
US3688406A (en) | 1970-08-07 | 1972-09-05 | William I Porter | Apparatus for and method of applying decay retardant compositions to teeth |
US3754332A (en) | 1970-09-09 | 1973-08-28 | L Warren | Treatment member |
US3784390A (en) | 1971-07-23 | 1974-01-08 | Hayashibara Biochem Lab | Shaped bodies of pullulan and their use |
US4251400A (en) | 1971-11-03 | 1981-02-17 | Borden, Inc. | Hot and cold water redispersible polyvinyl acetate adhesives |
US3902509A (en) | 1972-10-10 | 1975-09-02 | Colgate Palmolive Co | Disposable device for cleaning teeth |
US3844266A (en) | 1972-10-10 | 1974-10-29 | D Peterson | Capacitor discharge ignition circuit |
US4032627A (en) * | 1973-04-02 | 1977-06-28 | Koh-I-Noor Rapidograph, Inc. | Tooth whitening cosmetic composition |
DE2330869C2 (en) | 1973-06-16 | 1982-10-28 | Gerd 6070 Langen Hanel | Articulation or occlusion material |
IE42604B1 (en) | 1974-07-05 | 1980-09-10 | Schering Ag | A pharmaceutical preparation in the form of a foil having an active substance incorporated therein |
US4136145A (en) | 1974-07-05 | 1979-01-23 | Schering Aktiengesellschaft | Medicament carriers in the form of film having active substance incorporated therein |
US4136162A (en) | 1974-07-05 | 1979-01-23 | Schering Aktiengesellschaft | Medicament carriers in the form of film having active substance incorporated therein |
US3955281A (en) | 1974-12-05 | 1976-05-11 | Pacemaker Corporation | Disposable dental tray for topical application of fluoride gel and other dental medications |
US4138314A (en) | 1975-04-10 | 1979-02-06 | Basf Wyandotte Corporation | Method of forming diaphragms from discrete thermoplastic fibers requiring no bonding or cementing |
US3972995A (en) | 1975-04-14 | 1976-08-03 | American Home Products Corporation | Dosage form |
US4325855A (en) | 1975-09-10 | 1982-04-20 | Lingner And Fischer Gmbh | Adhesives |
US4072551A (en) | 1975-12-15 | 1978-02-07 | Hoffman-La Roche Inc. | Novel dosage form |
US4029757A (en) | 1975-12-15 | 1977-06-14 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical unit dosage forms |
US4029758A (en) | 1975-12-15 | 1977-06-14 | Hoffmann-La Roche Inc. | Preparation of pharmaceutical unit dosage forms |
US4031200A (en) | 1975-12-15 | 1977-06-21 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical unit dosage forms |
US4138814A (en) | 1976-03-08 | 1979-02-13 | Pacemaker Corporation | Disposable dental tray for topical application of fluoride gel and other dental medications |
JPS5728102Y2 (en) | 1976-11-10 | 1982-06-18 | ||
US4139627A (en) | 1977-10-06 | 1979-02-13 | Beecham Inc. | Anesthetic lozenges |
US4182222A (en) | 1978-02-16 | 1980-01-08 | Stahl Robert L | Coupon confining bag method |
US4335731A (en) | 1978-07-25 | 1982-06-22 | Bora Jr F William | Device for oral hygiene care |
US4324547A (en) | 1978-09-16 | 1982-04-13 | Vishay Intertechnology, Inc. | Dentistry technique |
US4292299A (en) | 1978-11-06 | 1981-09-29 | Teijin Limited | Slow-releasing medical preparation to be administered by adhering to a wet mucous surface |
US4308250A (en) | 1978-11-07 | 1981-12-29 | Beecham Group Limited | Sustained drug release device |
US4211330A (en) | 1979-02-01 | 1980-07-08 | Strock Alvin E | Oral health and hygiene kit |
US4363843A (en) | 1979-03-20 | 1982-12-14 | Raychem Limited | Seals |
US4376628A (en) | 1979-05-09 | 1983-03-15 | B.V. Gaba | Device for treating teeth |
US4842854A (en) * | 1979-05-29 | 1989-06-27 | Vsesojuzny Kardiologichesky Nauchny Tsentr Akademii Meditsinskiki Nauk Ssr | Antianginal plate for treating ischemic heart disease |
US4713239A (en) | 1979-05-29 | 1987-12-15 | Vsesojuny Kardiologichesky Nauchny Tsentr Adkaemii Meditsinski Nauk Sssr | Antianginal film and method of treating ischemic heart disease |
US4442258A (en) | 1979-07-04 | 1984-04-10 | Nitto Electric Industrial Co., Ltd. | Water-soluble pressure-sensitive adhesive composition |
US4294820A (en) | 1979-08-14 | 1981-10-13 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing phenylephrine |
US4307075A (en) | 1979-09-13 | 1981-12-22 | American Home Products Corporation | Topical treatment of aphthous stomatitis |
US4515162A (en) | 1980-03-14 | 1985-05-07 | Nitto Electric Industrial Co., Ltd. | Electrode pad |
US4517173A (en) | 1980-09-26 | 1985-05-14 | Nippon Soda Co. Ltd. | Mucous membrane-adhering film preparation and process for its preparation |
US4522806A (en) | 1980-10-10 | 1985-06-11 | Lever Brothers Company | Oral compositions for hexetidine and zinc salts for the synergistic inhibition of dental plaque |
US4331576A (en) | 1981-01-29 | 1982-05-25 | Herman Colon | Water-soluble, pressure-sensitive, hot-melt adhesives |
US4557692A (en) | 1981-02-12 | 1985-12-10 | Chorbajian Peter M | Occlusal splints and the method of manufacturing the same |
US4438258A (en) | 1981-06-12 | 1984-03-20 | National Research Development Corporation | Hydrogels |
US4503070A (en) | 1981-07-31 | 1985-03-05 | Eby Iii George A | Method for reducing the duration of the common cold |
GB2108841B (en) | 1981-10-20 | 1985-09-11 | Robert Gething | Sustained release layered pharmaceutical compositions |
US4373036A (en) | 1981-12-21 | 1983-02-08 | Block Drug Company, Inc. | Denture fixative composition |
US4460562A (en) | 1982-01-06 | 1984-07-17 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing propranolol |
US4428373A (en) | 1982-02-03 | 1984-01-31 | Sultan Dental Products Limited | Disposable dental tray |
GB2115431A (en) | 1982-02-25 | 1983-09-07 | Valleylab Inc | Hydrophilic, elastomeric, pressure-sensitive adhesive |
US4518721A (en) | 1982-03-26 | 1985-05-21 | Richardson-Vicks Inc. | Hydrophilic denture adhesive |
CA1209761A (en) | 1982-05-22 | 1986-08-19 | Avraham Fishman | Tooth cleaning device |
US4529748A (en) | 1982-08-16 | 1985-07-16 | Richardson Gmbh | Dental prosthesis adhesive |
EP0109269B1 (en) | 1982-11-12 | 1986-07-02 | Internationale Verbandstoff-Fabrik Schaffhausen | Shaped semi-solid articles |
EP0109269A1 (en) | 1982-11-12 | 1984-05-23 | Internationale Verbandstoff-Fabrik Schaffhausen | Shaped semi-solid articles |
US4537778A (en) | 1983-01-03 | 1985-08-27 | Colgate-Palmolive Company | Oral preparation |
US4431631A (en) | 1983-01-03 | 1984-02-14 | Colgate-Palmolive Company | Aqueous oral solution |
US4849213A (en) | 1983-03-01 | 1989-07-18 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery therof |
US4983379A (en) | 1983-03-01 | 1991-01-08 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery thereof |
US4687663B1 (en) | 1983-03-01 | 1997-10-07 | Chesebrough Ponds Usa Co | Dental preparation article and method for storage and delivery thereof |
US4687663A (en) | 1983-03-01 | 1987-08-18 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery thereof |
US4528180A (en) | 1983-03-01 | 1985-07-09 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery thereof |
US4554154A (en) | 1983-03-15 | 1985-11-19 | White Maurice J E | Dental product and method of dental treatment |
US4522805A (en) | 1983-06-08 | 1985-06-11 | Norman Gordon | Tooth and gum dentifrice |
US5024701A (en) | 1983-08-01 | 1991-06-18 | Hercules Incorporated | Denture adhesive composition |
US4532063A (en) | 1983-08-15 | 1985-07-30 | S. C. Johnson & Son, Inc. | Dissolvable bleach sheet |
US4971782A (en) | 1983-09-14 | 1990-11-20 | Peroxydent Group | Periodontal composition and method |
US4623394A (en) * | 1984-04-14 | 1986-11-18 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Gradually disintegrable molded article |
GB2159052A (en) | 1984-05-18 | 1985-11-27 | Bernard John Roberts | Artificial mucus material |
US4560351A (en) | 1984-07-05 | 1985-12-24 | Osborne Travis H | Method of and apparatus for applying dental treatment fluid |
US5186938A (en) | 1984-07-24 | 1993-02-16 | Key Pharmaceuticals, Inc. | Adhesive transdermal dosage layer |
US4544354A (en) | 1984-09-21 | 1985-10-01 | Gores Kenneth W | Anteriorly bridged dental trays |
US4777046A (en) | 1984-10-04 | 1988-10-11 | Nippon Kayaku Kabushiki Kaisha | Sheet-like preparation |
US4593053A (en) | 1984-12-07 | 1986-06-03 | Medtronic, Inc. | Hydrophilic pressure sensitive biomedical adhesive composition |
US4568536A (en) | 1985-02-08 | 1986-02-04 | Ethicon, Inc. | Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition |
US4650665A (en) | 1985-02-08 | 1987-03-17 | Ethicon, Inc. | Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition |
US4837008A (en) | 1985-04-09 | 1989-06-06 | Peroxydent Group | Periodontal composition and method |
EP0200508B1 (en) | 1985-04-27 | 1991-10-02 | Nitto Denko Corporation | Adhesive oral bandages and oral pharmaceutical preparations |
US4772470A (en) | 1985-04-27 | 1988-09-20 | Nitto Electric Industrial Co., Ltd. | Oral bandage and oral preparations |
US5288498A (en) | 1985-05-01 | 1994-02-22 | University Of Utah Research Foundation | Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments |
US4592488A (en) | 1985-05-24 | 1986-06-03 | Simon Gilbert I | Method for the preparation of chemotherapeutic compositions for the treatment of periodontal disease, compositions therefor and use thereof |
US4765983A (en) | 1985-06-05 | 1988-08-23 | Yamanouchi Pharmaceutical Co., Ltd. | Adhesive medical tapes for oral mucosa |
JPS61280423A (en) | 1985-06-05 | 1986-12-11 | Kiyuukiyuu Yakuhin Kogyo Kk | Mucosal application agent in oral cavity |
US4592487A (en) | 1985-07-03 | 1986-06-03 | Simon Gilbert I | Dentifrices |
US4755385A (en) | 1985-07-10 | 1988-07-05 | Dr. Karl Thomae, Gmbh | Oral pharmaceutical preparations containing 9-deoxo-11-deoxy-9,11-[imino[2-(2-methoxyethoxy)-ethylidene]-oxy]-(9S)-erythromycin |
US4690996A (en) | 1985-08-28 | 1987-09-01 | National Starch And Chemical Corporation | Inverse emulsions |
US4891400A (en) * | 1985-09-13 | 1990-01-02 | Bayer Aktiengesellschaft | Silicone molding compounds |
EP0219762B1 (en) | 1985-10-09 | 1990-12-27 | Desitin Arzneimittel GmbH | Process for the preparation of an administration and dosage for drugs, reagents or other active substances |
US4849246A (en) | 1985-10-09 | 1989-07-18 | Wolfgang Schmidt | Process for producing an administration or dosage form for drugs, reagents or other active ingredients |
US4741941A (en) | 1985-11-04 | 1988-05-03 | Kimberly-Clark Corporation | Nonwoven web with projections |
US4712460A (en) | 1985-11-18 | 1987-12-15 | Biotrack, Inc. | Integrated drug dosage form and metering system |
US4797283A (en) | 1985-11-18 | 1989-01-10 | Biotrack, Incorporated | Integrated drug dosage form and metering system |
US5229164A (en) | 1985-12-19 | 1993-07-20 | Capsoid Pharma Gmbh | Process for producing individually dosed administration forms |
US4983381A (en) | 1985-12-30 | 1991-01-08 | Futura Medical S.A. | Method and device for producing the whitening of live teeth with pathological and normal colorations |
US4755386A (en) | 1986-01-22 | 1988-07-05 | Schering Corporation | Buccal formulation |
EP0232006A2 (en) | 1986-01-22 | 1987-08-12 | Imperial Chemical Industries Plc | Compositions for surface treatment, polymers therefor, and method of surface treatment |
US4876092A (en) | 1986-02-01 | 1989-10-24 | Teikoku Seiyaku Kabushiki Kaisha | Sheet-shaped adhesive preparation applicable to oral cavity |
US4661070A (en) | 1986-03-17 | 1987-04-28 | Joshua Friedman | Method for bleaching discolored teeth |
US4722761A (en) | 1986-03-28 | 1988-02-02 | Baxter Travenol Laboratories, Inc. | Method of making a medical electrode |
US4770634A (en) | 1986-06-11 | 1988-09-13 | Pellico Michael A | Method for treating teeth with foamable fluoride compositions |
US4713243A (en) | 1986-06-16 | 1987-12-15 | Johnson & Johnson Products, Inc. | Bioadhesive extruded film for intra-oral drug delivery and process |
US4696757A (en) | 1986-06-16 | 1987-09-29 | American Home Products Corporation | Stable hydrogen peroxide gels |
US4799888A (en) | 1986-06-26 | 1989-01-24 | Golub Jeff E | Dental process with treated fabric |
US4728291A (en) | 1986-06-26 | 1988-03-01 | Golub Jeff E | Cloth wrap dental process |
EP0252459A1 (en) | 1986-07-07 | 1988-01-13 | Schering Corporation | Compartmentalized transdermal delivery system |
US4741700A (en) | 1986-07-16 | 1988-05-03 | Barabe David J | Dental breath freshening device |
AU601478B2 (en) | 1986-09-09 | 1990-09-13 | Desitin Arzneimittel Gmbh | Administration and dosage form for drug active agents, reagents or the like and process for the preparation thereof |
US4925670A (en) | 1986-09-09 | 1990-05-15 | Desitin Arzneimittel Gmbh | Administration and dosage form for drug active agents, reagents or the like and process for the preparation thereof |
US4927636A (en) | 1986-11-11 | 1990-05-22 | 501 Kabushiki Kaisha Hayashibara Kagaku Kenkyujo | Association complex comprising pullulan and polyethylene glycol, and preparation and uses of the same |
US4786253A (en) | 1986-12-04 | 1988-11-22 | Henneret Properties (Proprietary) Limited | Dental model articulator |
US4900554A (en) | 1986-12-24 | 1990-02-13 | Teikoku Seiyaku Co., Ltd. | Adhesive device for application to body tissue |
EP0273069B1 (en) | 1986-12-30 | 1992-10-14 | Uni Colloid Kabushiki Kaisha | Glucomannan/polyhydric alcohol composition and film prepared therefrom |
EP0273069A1 (en) | 1986-12-30 | 1988-07-06 | Uni Colloid Kabushiki Kaisha | Glucomannan/polyhydric alcohol composition and film prepared therefrom |
US4812308A (en) | 1987-02-20 | 1989-03-14 | Church & Dwight Co., Inc. | Hydrogen peroxide-releasing tooth powder |
US4860754A (en) | 1987-04-01 | 1989-08-29 | E. R. Squibb & Sons, Inc. | Electrically conductive adhesive materials |
US4839157A (en) | 1987-04-17 | 1989-06-13 | Colgate-Palmolive Company | Stable hydrogen peroxide dental gel containing fumed silicas |
EP0288420A1 (en) | 1987-04-17 | 1988-10-26 | Colgate-Palmolive Company | Stable hydrogen peroxide dental gel |
US4839156A (en) | 1987-04-17 | 1989-06-13 | Colgate-Palmolive Company | Stable hydrogen peroxide dental gel |
US4788052A (en) | 1987-04-17 | 1988-11-29 | Colgate-Palmolive Company | Stable hydrogen peroxide dental gel containing fumed silicas |
US4980152A (en) | 1987-08-06 | 1990-12-25 | Marion Laboratories | Oral preparation |
CA2000040C (en) | 1987-08-07 | 1995-10-03 | Skip Berg | Disposable tooth cleaning and polishing apparatus |
US4978531A (en) | 1987-08-13 | 1990-12-18 | Fordonal, S.A. | Clebopride transdermal patch |
US4931282A (en) | 1987-11-25 | 1990-06-05 | Minnesota Mining And Manufacturing Company | Pressure-sensitive medical sealant |
US4927634A (en) | 1987-12-16 | 1990-05-22 | Richardson-Vicks Inc. | Pharmaceutical compositions containing dyclonine HC1 and phenol |
US5197331A (en) * | 1987-12-30 | 1993-03-30 | Yazaki Corporation | Oscillatory angular speed detecting apparatus |
US4895721A (en) | 1988-01-22 | 1990-01-23 | Carter-Wallace Inc. | Peroxide gel dentifrice compositions |
EP0328317A1 (en) | 1988-02-04 | 1989-08-16 | Takeda Chemical Industries, Ltd. | Edible films |
US4915950A (en) | 1988-02-12 | 1990-04-10 | Cygnus Research Corporation | Printed transdermal drug delivery device |
WO1991006270A1 (en) | 1988-03-30 | 1991-05-16 | Watson Laboratories, Inc. | Mucoadhesive buccal dosage forms |
US4900552A (en) | 1988-03-30 | 1990-02-13 | Watson Laboratories, Inc. | Mucoadhesive buccal dosage forms |
JPH01279838A (en) | 1988-04-30 | 1989-11-10 | Kiyuukiyuu Yakuhin Kogyo Kk | Lysozyme chloride-containing plaster for gingivitis and pyorrhea |
US5438076A (en) * | 1988-05-03 | 1995-08-01 | Perio Products, Ltd. | Liquid polymer composition, and method of use |
US5160737A (en) | 1988-05-03 | 1992-11-03 | Perio Products Ltd. | Liquid polymer composition, and method of use |
US5330746A (en) | 1988-05-03 | 1994-07-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Dental varnish composition, and method of use |
US4902227A (en) | 1988-05-04 | 1990-02-20 | Pascal Company, Inc. | Dental treatment tray |
US5047244A (en) | 1988-06-03 | 1991-09-10 | Watson Laboratories, Inc. | Mucoadhesive carrier for delivery of therapeutical agent |
US4990089A (en) | 1988-08-23 | 1991-02-05 | Dunhall Pharmaceuticals, Inc. | Method and material for brightening teeth |
USRE34196E (en) | 1988-08-23 | 1993-03-16 | Dunhall Pharmaceuticals, Inc. | Method and material for brightening teeth |
FR2637175A1 (en) | 1988-10-03 | 1990-04-06 | Gaillard Eric | Tape for interdental cleaning |
US5427770A (en) * | 1988-11-28 | 1995-06-27 | Chesebrough-Ponds Usa Co., Division Of Conopco, Inc. | Dentifrices containing amino alkyl silicones |
US4948580A (en) | 1988-12-08 | 1990-08-14 | E. R. Squibb & Sons, Inc. | Muco-bioadhesive composition |
US5166233A (en) | 1989-01-31 | 1992-11-24 | Nitto Denko Corporation | Film applicable to oral mucosa and drug preparation comprising the same |
EP0381194B1 (en) | 1989-01-31 | 1994-08-31 | Nitto Denko Corporation | Drug preparation applicable to oral mucosa |
JPH07100186B2 (en) | 1989-02-10 | 1995-11-01 | 日産自動車株式会社 | Method and apparatus for manufacturing constant velocity joint outer ring |
US5122365A (en) | 1989-02-15 | 1992-06-16 | Natural White, Inc. | Teeth whitener |
US4910247A (en) | 1989-03-27 | 1990-03-20 | Gaf Chemicals Corporation | Adhesive composition |
US5064717A (en) | 1989-04-28 | 1991-11-12 | Kanzaki Paper Manufacturing Co., Ltd. | Adhesive sheet |
US4919615A (en) | 1989-04-28 | 1990-04-24 | Croll Theodore P | Orthodontic band cap |
US5620757A (en) * | 1989-05-23 | 1997-04-15 | Mitsubishi Rayon Co., Ltd. | Edible film and method of making same |
US5575655A (en) | 1989-07-03 | 1996-11-19 | Dunhall Pharmaceuticals, Inc. | Treatment of a tooth |
US5356291A (en) | 1989-07-03 | 1994-10-18 | Dunhall Pharmaceuticals, Inc. | Treatment of a tooth |
US4968251A (en) | 1989-07-03 | 1990-11-06 | Darnell Daniel H | Treatment of a tooth |
US5158825A (en) | 1989-07-13 | 1992-10-27 | Oskar Altwirth | Adherent insert for artificial teeth and process of manufacturing the insert |
US5770219A (en) | 1989-09-08 | 1998-06-23 | Cygnus Inc. | Solid matrix system for transdermal drug delivery |
US5980932A (en) | 1989-09-08 | 1999-11-09 | Cygnus, Inc. | Solid matrix system for transdermal drug delivery |
US5252334A (en) | 1989-09-08 | 1993-10-12 | Cygnus Therapeutic Systems | Solid matrix system for transdermal drug delivery |
US5271940A (en) | 1989-09-14 | 1993-12-21 | Cygnus Therapeutic Systems | Transdermal delivery device having delayed onset |
US4988500A (en) | 1989-09-29 | 1991-01-29 | The Procter & Gamble Company | Oral compositions |
US5354551A (en) | 1989-10-14 | 1994-10-11 | Desitin Arzneimittel Gmbh | Oral and dental hygiene preparation |
WO1991006289A1 (en) | 1989-10-31 | 1991-05-16 | Watson Laboratories, Inc. | Mucoadhesive carrier for delivery of therapeutical agent |
US5001170A (en) | 1989-12-01 | 1991-03-19 | Warner-Lambert Company | Denture stabilizer |
US4972946A (en) | 1990-01-08 | 1990-11-27 | Dale Whittaker | Disposable dental hygiene kit |
JPH03264523A (en) | 1990-03-13 | 1991-11-25 | Sekisui Chem Co Ltd | Bandage for application in oral cavity |
JPH03264522A (en) | 1990-03-13 | 1991-11-25 | Sekisui Chem Co Ltd | Bandage for application in oral cavity |
US5851512A (en) | 1990-03-22 | 1998-12-22 | Ultradent Products, Inc. | Dental compositions having a sticky matrix material for treating sensitive teeth |
US5855870A (en) | 1990-03-22 | 1999-01-05 | Ultradent Products, Inc. | Method for treating sensitive teeth |
US5725843A (en) | 1990-03-22 | 1998-03-10 | Ultradent Products, Inc. | Methods for bleaching teeth surfaces |
US5985249A (en) | 1990-03-22 | 1999-11-16 | Ultradent Products, Inc. | Sticky dental compositions for adhering a passive-type dental tray over a person's teeth |
US5846058A (en) | 1990-03-22 | 1998-12-08 | Ultradent Products, Inc. | Dental trays having thin walls for increased patient comfort |
US5770182A (en) | 1990-03-22 | 1998-06-23 | Ultradent Products, Inc. | Methods for treating teeth with anticariogenic and antimicrobial dental compositions |
US5759037A (en) | 1990-03-22 | 1998-06-02 | Ultradent Products Inc | Methods for manufacturing dental trays having thin walls for increased comfort |
US5746598A (en) | 1990-03-22 | 1998-05-05 | Ultradent Products, Inc. | Dental bleaching compositions including a sticky matrix material |
US6036943A (en) | 1990-03-22 | 2000-03-14 | Ultradent Products, Inc. | Methods for treating a person's teeth using sticky dental compositions in combination with passive-type dental trays |
US5770105A (en) | 1990-03-22 | 1998-06-23 | Ultradent Products, Inc. | Methods for manufacturing sticky bleaching compositions |
US5098303A (en) | 1990-03-22 | 1992-03-24 | Ultradent Products, Inc. | Method for bleaching teeth |
US5759038A (en) | 1990-03-22 | 1998-06-02 | Fischer; Dan E. | Dental kit for applying sticky dental bleaching compositions to a person's teeth |
US5376006A (en) | 1990-03-22 | 1994-12-27 | Ultradent Products, Inc. | Dental bleaching compositions and methods for bleaching teeth surfaces |
US5409631A (en) | 1990-03-22 | 1995-04-25 | Ultradent Products | Dental bleaching compositions and methods for bleaching teeth surfaces |
US5234342A (en) | 1990-03-22 | 1993-08-10 | Ultradent Products, Inc. | Sustained release method for treating teeth surfaces |
WO1991016041A1 (en) | 1990-04-26 | 1991-10-31 | Smith Kline & French Laboratories Limited | Pharmaceutical compositions |
US5474780A (en) | 1990-04-27 | 1995-12-12 | Allergan, Inc. | Monolithic maleic anhydride drug delivery systems |
US5629003A (en) | 1990-06-07 | 1997-05-13 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Rapidly disintegrating sheet-like presentations of multiple dosage units |
US5455043A (en) | 1990-06-13 | 1995-10-03 | Fischel-Ghodsian; Fariba | Device for controlled release of vaporous medications through nasal route |
US5059417A (en) | 1990-06-26 | 1991-10-22 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Peroxide gel dentifrice |
US5380198A (en) | 1990-08-06 | 1995-01-10 | Suhonen; Jouko | Matrix for dental medicine and a device for the fabricaton of matrix bands |
US5165424A (en) * | 1990-08-09 | 1992-11-24 | Silverman Harvey N | Method and system for whitening teeth |
US5344702A (en) | 1990-09-14 | 1994-09-06 | Hoechst Celanese Corp. | Coated fibers |
US5401495A (en) | 1990-10-10 | 1995-03-28 | Natural White, Inc. | Teeth whitener |
US5076791A (en) | 1990-10-22 | 1991-12-31 | Madray Jr George | Professional home method for bleaching teeth |
US5290566A (en) | 1990-12-18 | 1994-03-01 | Schow Robert S | Tooth whitening formulation and method |
US5326685A (en) | 1991-02-13 | 1994-07-05 | Gaglio Thomas J | Viscous fluid dispensing apparatus |
US5332576A (en) | 1991-02-27 | 1994-07-26 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
US5401528A (en) * | 1991-03-19 | 1995-03-28 | Thera Patent GmbH & Co. KG Geselleschaft fur industrielle Schutzrechte | Use of compositions based on organically modified silicic acid polycondensates for coating teeth and dental prostheses |
US5707736A (en) | 1991-04-04 | 1998-01-13 | Sion Texo Medic Ltd. | Products having anti-microbial activity |
US5425953A (en) * | 1991-04-23 | 1995-06-20 | Perio Products Limited | Polymer composition for tooth bleaching and other dental uses thereof |
US5472704A (en) | 1991-05-30 | 1995-12-05 | Recordati S.A., Chemical And Pharmaceutical Company | Pharmaceutical controlled-release composition with bioadhesive properties |
US5084268A (en) | 1991-06-17 | 1992-01-28 | Dental Concepts, Inc. | Tooth whitening dentifrice |
JPH05236885A (en) | 1991-07-17 | 1993-09-17 | Tazawa Toshihiko | Flavoring and refreshing food formed into film |
US5211559A (en) | 1991-07-18 | 1993-05-18 | Gillette Canada Inc. | Dental treatment tray for holding medicament gel |
US5340581A (en) | 1991-08-23 | 1994-08-23 | Gillette Canada, Inc. | Sustained-release matrices for dental application |
US5723132A (en) | 1991-08-23 | 1998-03-03 | Gillette Canada Inc. | Sustained-release matrices for dental application |
US5851551A (en) | 1991-08-23 | 1998-12-22 | The Gillette Company | Sustained-release matrices for dental application |
US20020081556A1 (en) | 1991-08-23 | 2002-06-27 | The Gillette Company, A Delaware Corporation | Sustained-release matrices for dental application |
US20030049209A1 (en) | 1991-08-23 | 2003-03-13 | The Gillette Company, A Delaware Corporation | Sustained-release matrices for dental application |
US5256402A (en) | 1991-09-13 | 1993-10-26 | Colgate-Palmolive Company | Abrasive tooth whitening dentifrice of improved stability |
US5171564A (en) | 1991-09-13 | 1992-12-15 | Colgate-Palmolive | Aqueous tooth whitening dentifrice |
US5192802A (en) | 1991-09-25 | 1993-03-09 | Mcneil-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
US5462749A (en) | 1991-09-25 | 1995-10-31 | Mcnell-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
US5314915A (en) | 1991-09-25 | 1994-05-24 | Mcneil-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
US5639445A (en) | 1991-10-25 | 1997-06-17 | Colgate-Palmolive Company | Dental material and method for applying preventative and therapeutic agents |
US5310563A (en) | 1991-10-25 | 1994-05-10 | Colgate-Palmolive Company | Dental material and method for applying preventative and therapeutic agents |
EP0539751A1 (en) | 1991-10-28 | 1993-05-05 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
JPH05124954A (en) | 1991-10-29 | 1993-05-21 | Mitsubishi Kasei Corp | Sheetlike solid medicinal composition |
CA2078960A1 (en) | 1992-04-21 | 1993-10-22 | John Wick | Hydrogel applicator and methods of making same |
EP0569797A2 (en) | 1992-05-04 | 1993-11-18 | Digestive Care Inc. | Intraoral device for slow medicament release |
US5529782A (en) | 1992-05-07 | 1996-06-25 | Staab; Robert | Dissolvable device for contraception or delivery of medication |
US5393528A (en) | 1992-05-07 | 1995-02-28 | Staab; Robert J. | Dissolvable device for contraception or delivery of medication |
US5780045A (en) | 1992-05-18 | 1998-07-14 | Minnesota Mining And Manufacturing Company | Transmucosal drug delivery device |
US5599553A (en) | 1992-09-01 | 1997-02-04 | Dong Kook Pharmaceutical Co., Ltd. | Local drug delivery film for periodontal treatment |
US5579523A (en) * | 1992-10-13 | 1996-11-26 | Sony Corporation | Method for controlled locking/unlocking of a system using a locking mode flag during an interrupt routine |
EP0599435A1 (en) | 1992-11-19 | 1994-06-01 | Colgate-Palmolive Company | Oral composition having improved tooth whitening effect |
US5980249A (en) | 1992-11-24 | 1999-11-09 | Folh, Llc | Method and device for treatment of dentition |
US5575654A (en) | 1992-11-24 | 1996-11-19 | Fontenot; Mark G. | Apparatus and method for lightening teeth |
US5340314A (en) | 1992-11-27 | 1994-08-23 | Tarvis Jo Ellen | Method of bonding and relining dentures |
US5660178A (en) | 1992-12-01 | 1997-08-26 | Minnesota Mining And Manufacturing Company | Hydrophilic pressure sensitive adhesives |
EP0637446A1 (en) | 1993-06-08 | 1995-02-08 | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. | Dental floss provided with chemotherapy agents |
EP0636378A1 (en) | 1993-07-28 | 1995-02-01 | JOHNSON & JOHNSON MEDICAL, INC. | Absorbable composite materials for use in the treatment of periodontal disease |
US5593684A (en) | 1993-08-04 | 1997-01-14 | Pharmacia Ab | Method and therapeutic system for smoking cessation |
US5700478A (en) | 1993-08-19 | 1997-12-23 | Cygnus, Inc. | Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavity |
JP3198754B2 (en) | 1993-10-04 | 2001-08-13 | 日産自動車株式会社 | Graphic instruction receiving device for CAD system |
CA2095445A1 (en) | 1994-01-10 | 1995-07-11 | Howard Rocket | Index dental tooth cleanser |
US5626866A (en) | 1994-03-07 | 1997-05-06 | Theratech, Inc. | Drug-containing adhesive composite transdermal delivery device |
US5819765A (en) | 1994-05-11 | 1998-10-13 | Mittiga; Maria Ida | Finger glove comprising areas prepared for oral hygiene |
US5505933A (en) | 1994-06-27 | 1996-04-09 | Colgate Palmolive Company | Desensitizing anti-tartar dentifrice |
US5560379A (en) | 1994-08-12 | 1996-10-01 | Pieczenik; George | Dental paper pick and flosser |
RU2075965C1 (en) | 1994-09-29 | 1997-03-27 | Гарник Алексанович Чухаджян | Agent for mouth cavity illness treatment |
US5613942A (en) * | 1994-10-04 | 1997-03-25 | Minnesota Mining And Manufacturing Company | Adhesive sheet material suitable for use on wet surfaces |
US5522726A (en) | 1994-10-27 | 1996-06-04 | Hodosh; Milton | Method for anesthetizing teeth |
US5565190A (en) | 1994-11-14 | 1996-10-15 | Colgate Palmolive Company | Dentifrice compositions containing reactive ingredients stabilized with alkali metal compounds |
CA2162536C (en) | 1994-11-14 | 2007-12-04 | Donald P. Hsu | Dentifrice compositions having improved anticalculus properties |
CA2162885A1 (en) | 1994-11-14 | 1996-05-15 | Donald P. Hsu | Stabilized dentifrice compositions containing reactive ingredients |
CA2162812C (en) | 1994-11-14 | 2008-03-25 | John Santalucia | Dentifrice compositions containing reactive ingredients stabilized with alkali metal compounds |
US6024891A (en) * | 1994-12-22 | 2000-02-15 | The Procter & Gamble Company | Silicone compositions |
US6008171A (en) * | 1994-12-22 | 1999-12-28 | The Procter & Gamble Company | Cleansing compositions |
US6123950A (en) * | 1994-12-22 | 2000-09-26 | The Procter & Gamble Company | Silicone compositions |
US5856282A (en) * | 1994-12-22 | 1999-01-05 | The Procter & Gamble Company | Silicone compositions |
JPH08325128A (en) | 1995-03-31 | 1996-12-10 | Sunstar Inc | Long term sustainable base for oral cavity and composition using the same |
US5707235A (en) | 1995-04-03 | 1998-01-13 | Knutson; Eric J. | Dental tray spacer |
US5620322A (en) | 1995-07-27 | 1997-04-15 | Lococo; Michael | Dental matrix strip |
EP0763358A1 (en) | 1995-09-12 | 1997-03-19 | Bristol-Myers Squibb Company | Buccal delivery system for therapeutic agents |
US5922307A (en) | 1995-09-25 | 1999-07-13 | R. Eric Montgomery | Tooth bleaching compositions |
US6331292B1 (en) | 1995-09-25 | 2001-12-18 | R. Eric Montgomeory | Tooth bleaching compositions |
US6488914B2 (en) | 1995-09-25 | 2002-12-03 | R. Eric Montgomery | Tooth bleaching compositions |
US5611687A (en) | 1995-11-06 | 1997-03-18 | Dental Concepts Inc. | Oral hygiene delivery system |
US6139823A (en) * | 1995-11-07 | 2000-10-31 | The Procter & Gamble Company | Transfer resistant cosmetic compositions |
US6340466B1 (en) * | 1995-11-07 | 2002-01-22 | The Procter & Gamble Company | Transfer resistant cosmetic compositions |
US6074654A (en) * | 1995-11-07 | 2000-06-13 | The Procter & Gamble Company | Transfer resistant cosmetic compositions |
US6019962A (en) * | 1995-11-07 | 2000-02-01 | The Procter & Gamble Co. | Compositions and methods for improving cosmetic products |
US6071503A (en) * | 1995-11-07 | 2000-06-06 | The Procter & Gamble Company | Transfer resistant cosmetic compositions |
US6406683B1 (en) * | 1995-11-07 | 2002-06-18 | The Procter & Gamble Company | Transfer resistant cosmetic compositions |
US5713738A (en) | 1995-12-12 | 1998-02-03 | Britesmile, Inc. | Method for whitening teeth |
US5662758A (en) | 1996-01-10 | 1997-09-02 | The Procter & Gamble Company | Composite material releasably sealable to a target surface when pressed thereagainst and method of making |
US6083421A (en) * | 1996-01-19 | 2000-07-04 | Huang; Lizi | Film coating composition for whitening teeth |
US5631000A (en) | 1996-03-11 | 1997-05-20 | Laclede Professional Products, Inc. | Anhydrous tooth whitening gel |
US5678273A (en) | 1996-03-20 | 1997-10-21 | Porcelli; V. Lorenzo | Disposable oral hygiene applicator |
JPH1017448A (en) | 1996-06-28 | 1998-01-20 | Lion Corp | Plaster for oral cavity |
JPH1026639A (en) | 1996-07-11 | 1998-01-27 | Hitachi Ltd | Current sensor and electric device housing current sensor |
US5827591A (en) | 1996-10-08 | 1998-10-27 | Tricor Direct, Inc. | Removable adhesive notes for an industrial setting |
US6159498A (en) | 1996-10-18 | 2000-12-12 | Virotex Corporation | Bioerodable film for delivery of pharmaceutical compounds of mucosal surfaces |
US5800832A (en) * | 1996-10-18 | 1998-09-01 | Virotex Corporation | Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces |
US20050147658A1 (en) | 1996-10-18 | 2005-07-07 | Virotex Corporation | Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces |
US6709671B2 (en) | 1996-11-11 | 2004-03-23 | Lts Lohmann Therapie-Systeme Ag | Water soluble film for oral administration with instant wettability |
US6592887B2 (en) | 1996-11-11 | 2003-07-15 | Lts Lohmann Therapie-Systeme Ag | Water soluble film for oral administration with instant wettability |
US20020127190A1 (en) | 1996-11-11 | 2002-09-12 | Zerbe Horst Georg | Water soluble film for oral administration with instant wattability |
US5948430A (en) | 1996-11-11 | 1999-09-07 | Lts Lohmann Therapie-Systeme Gmbh | Water soluble film for oral administration with instant wettability |
US6284264B1 (en) | 1996-11-11 | 2001-09-04 | Lts Lohmann Therapie-Systeme Gmbh | Water soluble film for oral administration with instant wettability |
US6177096B1 (en) | 1996-11-11 | 2001-01-23 | Lts Lohmann Therapie-Systeme Gmbh | Water soluble film for oral administration with instant wettability |
US5766011A (en) | 1996-11-27 | 1998-06-16 | Sibner; Jeffrey A. | Dental bleaching composition and method |
US6682756B1 (en) | 1996-12-16 | 2004-01-27 | Lts Lohmann Therapie-Systeme Ag | Individually dosed foil-form presentation which decomposes rapidly on contact with liquid and contains an active substance, in particular an aromatic substance |
US5858332A (en) | 1997-01-10 | 1999-01-12 | Ultradent Products, Inc. | Dental bleaching compositions with high concentrations of hydrogen peroxide |
US6094889A (en) | 1997-02-25 | 2000-08-01 | Exxon Chemical Patents, Inc. | Method of form and seal packaging |
US5953885A (en) | 1997-04-08 | 1999-09-21 | Retail Communications Corp. | Cosmetic sampler and method of making using bulk thin film application techniques |
US6182420B1 (en) | 1997-04-08 | 2001-02-06 | Retail Communications Corp. | Method of making a cosmetic sampler using bulk thin film application techniques |
US6306370B1 (en) | 1997-05-30 | 2001-10-23 | Ultradent Products, Inc. | Compositions and methods for whitening and desensitizing teeth |
US5989569A (en) | 1997-06-06 | 1999-11-23 | The Procter & Gamble Company | Delivery system for a tooth whitener using a permanently deformable strip of material |
US5891453A (en) | 1997-06-06 | 1999-04-06 | The Procter & Gamble Company | Delivery system for a tooth whitener using a strip of material having low flexural stiffness |
US6045811A (en) | 1997-06-06 | 2000-04-04 | The Procter & Gamble Company | Delivery system for an oral care substance using a permanently deformable strip of material |
US5968633A (en) | 1997-06-06 | 1999-10-19 | The Procter & Gamble Company | Selectively-activatible sheet material for dispensing and dispersing a substance onto a target surface |
US6096328A (en) | 1997-06-06 | 2000-08-01 | The Procter & Gamble Company | Delivery system for an oral care substance using a strip of material having low flexural stiffness |
US5879691A (en) | 1997-06-06 | 1999-03-09 | The Procter & Gamble Company | Delivery system for a tooth whitener using a strip of material having low flexural stiffness |
WO1998055079A2 (en) * | 1997-06-06 | 1998-12-10 | The Procter & Gamble Company | A delivery system for an oral care substance using a strip of material having low flexural stiffness |
US6136297A (en) | 1997-06-06 | 2000-10-24 | The Procter & Gamble Company | Delivery system for an oral care substance using a strip of material having low flexural stiffness |
US5894017A (en) | 1997-06-06 | 1999-04-13 | The Procter & Gamble Company | Delivery system for an oral care substance using a strip of material having low flexural stiffness |
US6551579B2 (en) | 1997-06-06 | 2003-04-22 | The Procter & Gamble Company | Delivery systems for a tooth whitener |
US6197331B1 (en) | 1997-07-24 | 2001-03-06 | Perio Products Ltd. | Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity |
US20030099690A1 (en) | 1997-10-08 | 2003-05-29 | Tsutomu Awamura | Rapidly soluble film preparation |
US20050048102A1 (en) | 1997-10-16 | 2005-03-03 | Virotex Corporation | Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces |
US6072100A (en) | 1998-01-28 | 2000-06-06 | Johnson & Johnson Consumer Products, Inc. | Extrudable compositions for topical or transdermal drug delivery |
WO1999062472A1 (en) * | 1998-06-03 | 1999-12-09 | Wolf Robert O | System for whitening teeth surfaces |
US20020127254A1 (en) | 1998-06-25 | 2002-09-12 | Lavipharm Laboratories Inc. | Devices for local and systemic delivery of active substance and methods of manufacturing thereof |
WO1999066870A1 (en) | 1998-06-25 | 1999-12-29 | Lavipharm Laboratories, Inc. | A device and method for the treatment of erectile dysfunction |
US6537565B2 (en) | 1998-07-07 | 2003-03-25 | Atrix Laboratories, Inc. | Filamentous porous films and methods for producing the same |
US20050031675A1 (en) | 1998-09-25 | 2005-02-10 | Sau-Hung Spence Leung | Fast dissolving orally consumable film |
US20010022964A1 (en) | 1998-09-25 | 2001-09-20 | Leung Sau-Hung S. | Fast dissolving orally consumable films |
US6596298B2 (en) | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
US6129929A (en) * | 1998-10-30 | 2000-10-10 | Noven Pharmaceuticals, Inc. | Patch applicator |
US6309625B1 (en) | 1998-11-12 | 2001-10-30 | Ultradent Products, Inc. | One-part dental compositions and methods for bleaching and desensitizing teeth |
US6552024B1 (en) | 1999-01-21 | 2003-04-22 | Lavipharm Laboratories Inc. | Compositions and methods for mucosal delivery |
WO2000042992A3 (en) | 1999-01-21 | 2000-10-19 | Lavipharm Lab Inc | Compositions and methods for mucosal delivery |
US6337086B1 (en) * | 1999-02-06 | 2002-01-08 | Dow Corning Corporation | Pressure sensitive adhesive compositions for transdermal drug delivery devices |
US6277458B1 (en) | 1999-03-15 | 2001-08-21 | The Procter & Gamble Company | Release strip with partible break to facilitate |
US6090401A (en) | 1999-03-31 | 2000-07-18 | Mcneil-Ppc, Inc. | Stable foam composition |
US6210699B1 (en) | 1999-04-01 | 2001-04-03 | Watson Pharmaceuticals, Inc. | Oral transmucosal delivery of drugs or any other ingredients via the inner buccal cavity |
US6231957B1 (en) | 1999-05-06 | 2001-05-15 | Horst G. Zerbe | Rapidly disintegrating flavor wafer for flavor enrichment |
US6673361B1 (en) | 1999-05-19 | 2004-01-06 | Nof Corporation | Polymer, in vivo degradable material, and use |
US6737080B1 (en) | 1999-06-04 | 2004-05-18 | Lts Lohmann Therapie-Systeme Ag | Composite laminate and method for its production |
US6375963B1 (en) | 1999-06-16 | 2002-04-23 | Michael A. Repka | Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation thereof |
WO2001001958A1 (en) | 1999-07-02 | 2001-01-11 | The Procter & Gamble Company | Delivery system for oral care compositions comprising organosiloxane reins using a removable backing strip |
US6322360B1 (en) | 1999-10-22 | 2001-11-27 | 3M Innovative Properties Company | Medication retention assembly for oral delivery tray |
US6703040B2 (en) | 2000-01-11 | 2004-03-09 | Intralytix, Inc. | Polymer blends as biodegradable matrices for preparing biocomposites |
US6682721B2 (en) | 2000-03-17 | 2004-01-27 | Lg Household & Healthcare Ltd. | Patches for teeth whitening |
US20040136927A1 (en) | 2000-03-17 | 2004-07-15 | Ji-Young Kim | Apparatus and method for whitening teeth |
US6689344B2 (en) | 2000-03-17 | 2004-02-10 | Lg Household & Healthcare Ltd. | Patches for teeth whitening |
EP1153594A2 (en) | 2000-04-21 | 2001-11-14 | Coden Co., Ltd. | Cosmetic coating composition, especially for teeth, remover, and intraoral lip supporter |
US6517350B2 (en) | 2000-05-26 | 2003-02-11 | Dentovations Inc. | Method for whitening teeth |
US6582708B1 (en) * | 2000-06-28 | 2003-06-24 | The Procter & Gamble Company | Tooth whitening substance |
WO2002002085A2 (en) | 2000-07-04 | 2002-01-10 | Lts Lohmann Therapie-Systeme Ag | Rapidly-decomposing administrable form for releasing active ingredients in the oral cavity or in bodily cavities |
WO2002002085A3 (en) | 2000-07-04 | 2002-06-20 | Lohmann Therapie Syst Lts | Rapidly-decomposing administrable form for releasing active ingredients in the oral cavity or in bodily cavities |
US6461158B1 (en) | 2000-08-14 | 2002-10-08 | The Procter & Gamble Company | Products and methods that simulate changes in tooth color |
WO2002026196A1 (en) | 2000-09-26 | 2002-04-04 | Patacca Thomas R | Tooth coating composition |
US6379654B1 (en) | 2000-10-27 | 2002-04-30 | Colgate Palmolive Company | Oral composition providing enhanced tooth stain removal |
WO2002043657A2 (en) | 2000-11-30 | 2002-06-06 | Wm. Wrigley Jr. Company | Improved pullulan free edible film compositions and methods of making the same |
US20020131990A1 (en) | 2000-11-30 | 2002-09-19 | Barkalow David G. | Pullulan free edible film compositions and methods of making the same |
US20040101496A1 (en) | 2001-01-27 | 2004-05-27 | Tianming Chen | Bleaching device comprising a barrier layer and a bleaching composition comprising polyvinylpyrrolidone |
US6730316B2 (en) | 2001-01-27 | 2004-05-04 | Ultradent Products, Inc. | Dental bleach |
US6500408B2 (en) | 2001-01-27 | 2002-12-31 | Jc Technologies, Inc. | Enamel-safe tooth bleach and method for use |
US6514483B2 (en) | 2001-03-12 | 2003-02-04 | Colgate Palmolive Company | Strip for whitening tooth surfaces |
US6419906B1 (en) | 2001-03-12 | 2002-07-16 | Colgate Palmolive Company | Strip for whitening tooth surfaces |
US6719995B2 (en) | 2001-03-19 | 2004-04-13 | The Procter & Gamble Company | Systems for delivering a cosmetic and/or therapeutic active to oral surfaces using an integral carrier |
US20030170308A1 (en) | 2001-05-01 | 2003-09-11 | Cleary Gary W. | Hydrogel compositions |
US20030152528A1 (en) | 2001-05-01 | 2003-08-14 | Parminder Singh | Hydrogel compositions for tooth whitening |
US20040105834A1 (en) | 2001-05-01 | 2004-06-03 | Corium International | Hydrogel compositions with an erodible backing member |
WO2002092049A2 (en) | 2001-05-14 | 2002-11-21 | 3M Innovative Properties Company | System for delivering cosmetics and pharmaceuticals |
US20020187181A1 (en) | 2001-05-14 | 2002-12-12 | 3M Innovative Properties Company | System for delivering cosmetics and pharmaceuticals |
US20030194382A1 (en) | 2001-06-23 | 2003-10-16 | Sug-Youn Chang | Multi-layer patches for teeth whitening |
WO2003011259A1 (en) | 2001-07-30 | 2003-02-13 | Wm. Wrigley Jr. Company | Improved edible film formulations containing maltodextrin |
US20030035841A1 (en) | 2001-07-30 | 2003-02-20 | Dzija Michael R. | Edible film formulations containing maltodextrin |
US20030054039A1 (en) | 2001-07-30 | 2003-03-20 | Zyck Daniel J. | Edible film formulations containing maltodextrin |
US20040062724A1 (en) | 2001-08-16 | 2004-04-01 | Moro Daniel G. | Erodible film for treating the surfaces of teeth |
US6419903B1 (en) | 2001-08-20 | 2002-07-16 | Colgate Palmolive Company | Breath freshening film |
JP2003137756A (en) | 2001-11-06 | 2003-05-14 | Kenji Nakamura | Patch for bleaching tooth |
WO2003043659A1 (en) | 2001-11-16 | 2003-05-30 | Givaudan Sa | Edible film |
US20030219390A1 (en) | 2002-05-24 | 2003-11-27 | Santarpia R. Peter | Liquid tooth whitening composition |
US20030228264A1 (en) | 2002-06-06 | 2003-12-11 | Perna Salvatore F. | Dissolvable teeth whitening apparatus |
US20040022755A1 (en) | 2002-08-02 | 2004-02-05 | Satish Kamath | Polyacrylic film forming compositions |
US20040043134A1 (en) | 2002-08-27 | 2004-03-04 | Corriveau Christine Leclair | Rolled edible thin film products and methods of making same |
US20040086468A1 (en) | 2002-10-30 | 2004-05-06 | Isp Investments Inc. | Delivery system for a tooth whitener |
US20040091432A1 (en) | 2002-11-04 | 2004-05-13 | Dulin Jacques M. | Oral hygiene system and method of treatment |
US20040096569A1 (en) | 2002-11-15 | 2004-05-20 | Barkalow David G. | Edible film products and methods of making same |
US6669930B1 (en) | 2003-01-15 | 2003-12-30 | Colgate Palmolive Company | Liquid tooth whitening gel |
Non-Patent Citations (43)
Title |
---|
"Tooth Bleaching, Home-Use Products", Clinical Research Associates Newsletter, 1989, pp. 1-4. |
"Tooth Bleaching, Home-Use Products", Clinical Research Associates Newsletter, 1989, vol. 3, Issue 12. |
3M Dental Products 2000 Product Catalog, 32 pages. |
Besner, E., et al., Practical Endodontics, 1994, pp. 7-15, 178-180; Mosby-Year Book, Inc. |
Carl M. Russell, et al, "Dentist-supervised home bleaching with ten percent carbamide peroxide gel: a six month study", Journal of Esthetic Dentistry, 1996, vol. 8, No. 4, pp. 177-182. |
Carolyn F. G. Wilson, et al, "Color change following vital bleaching of tetracycline-stained teeth" Pediatric Dentistry, 1985, vol. 7, No. 3, pp. 205-208. |
Christopher J. Woolverton, "Toxicity of two carbamide peroxide products used in nightguard vital bleaching", American Journal of Dentistry, 1993, vol. 6, No. 6, pp. 310-314. |
Claudia Paula Drew, "Teeth Bleaching . . . a Vital technique for you to know", Sep./Oct. 1988, pp. 23-25. |
Fonda G. Robinson, et al, "Effect of 10 percent carbamide peroxide on color of provisional restoration materials", JADA, 1997, vol. 128, pp. 727-731. |
Howard Frysh, BDS, DDS., "Chemistry of Bleaching", Complete Dental Bleaching, 1995, pp. 25-32 & 90-97, Quintessence Publishing Co, Inc. |
James W. Curtis, et al, "Assessing the effects of 10 percent carbamide peroxide on oral soft tissues", JADA, 1996, vol. 127, pp. 1218-1223. |
M.S. McCracken, "Demineralization effects of 10 percent carbamide peroxide", Journal of Dentistry, 1996, vol. 24, No. 6, pp. 395-398. |
Messing, J.J., et al., Color Atlas of Endodontics, 1988, pp. 106-107, 135-140, 173-175, 257-259; The C.V. Mosby Company, Ltd. |
Office Action from the United States Patent & Trademark Office, dated May 28, 2003, issued on U.S. Appl. No. 09/864,686, filed May 24, 2001, assignee-The Procter & Gamble Company, now abandoned. |
Office Action from the United States Patent & Trademark Office, dated Sep. 5, 2003, issued on U.S. Appl. No. 09/864,686, filed May 24, 2001, assignee-The Procter & Gamble Company, now abandoned. |
Ralph H. Leonard Jr., et al, "Risk factors for developing tooth sensitivity and gingival irritation associated with nightguard vital bleaching", Esthetic Dentristy, 1997, vol. 28, No. 8, pp. 527-534. |
Ralph H. Leonard, et al, "Change in pH of plaque and 10% carbamide peroxide solution during nightguard vial bleaching treatment" Esthetic Dentistry, 1994, vol. 25, No. 12, pp. 819-823. |
Ralph H. Leonard, et al, "Salivary pH changes during 10% carbamide peroxide bleaching" Dental Research, 1994, vol. 25, No. 8, pp. 547-550. |
S.M. Newman, et al., "Tray-Forming Technique for Dentist-Supervised Home Bleaching", Quintessence International, 1995, pp. 447-453, vol. 26, No. 7. |
Sue Ellen Richardson, "Home bleaching: effectiveness, history, technique, bleaches, cost and safety" The Journal of the Greater Houston Dental Society, 1989, pp. 22-26. |
V.B. Haywood, "History, Safety, and Effectiveness of Current Bleaching Techniques and Applications of the Nightguard Vital Bleaching Technique", Quintessence International, 1992, vol. 23, No. 7, pp. 471-488. |
V.B. Haywood, "Nightguard Vital Bleaching", Dentistry Today, 1997, pp. 86-91. |
V.B. Haywood, et al., "Nightguard Vital Bleaching", Quintessence International, 1989, vol. 20, No. 3, pp. 173-176, 19th International Meeting on Dental Implants and Transplants, Bologna, Italy. |
Van B. Haywood, "Achieving, maintaining and recovering successful tooth bleaching", Journal of Esthetic Dentistry, 1996, vol. 8, No. 1, pp. 31-38. |
Van B. Haywood, "Bleaching of vital and notvital teeth", Periodontology and Restorative Dentistry, 1992, pp. 142-149. |
Van B. Haywood, "Commonly asked question about nightguard vital bleaching", The Dental Assistant, Mar./Apr. 1996, pp. 6-12. |
Van B. Haywood, "Commonly asked questions about nightguard vital bleaching", IDA Journal, 1993, pp. 28-33. |
Van B. Haywood, "Considerations and variations of dentist-prescribed,home-applied vital tooth-bleaching techniques", Compend Contin Educ Dent, 1994, Suppl.No. 17, pp. s616-s621. |
Van B. Haywood, "Effectiness, side effects and long-term status of nightguard vital bleaching", JADA, 1994, vol. 125, pp. 1219-1226. |
Van B. Haywood, "Efficacy of foam liner in 10% carbamide peroxide bleaching technique", Esthetic Dentistry, 1993, vol. 24, No. 9, pp. 663-666. |
Van B. Haywood, "Efficacy of six months of nightguard vital bleaching of tetracycline-stained teeth", Journal of Esthetic Dentistry, 1997, vol. 9, No. 1, pp. 13-19. |
Van B. Haywood, "Historical development of whiteners: clinical safety and efficacy", Aesthetics, 1997, April update, pp. 98-104. |
Van B. Haywood, "Historical development of whiteners: clinical safety and efficacy", Aesthetics, 1997, pp. 98-104. |
Van B. Haywood, "History, safety and effectiveness of current bleaching techniques and applications of the nightguard vital bleaching technique", Esthetic Dentistry, 1992, vol. 23, No. 7, pp. 471-488. |
Van B. Haywood, "Nightguard vital bleaching, a history and products update: Part 1", Esthetic Dentistry Update, 1991, vol. 2, No. 4, pp. 63-66. |
Van B. Haywood, "Nightguard vital bleaching, a history and products update: Part 2", Esthetic Dentistry Update, 1991, vol. 2, No. 5, pp. 82-85. |
Van B. Haywood, "Nightguard vital bleaching: current concepts and research", JADA, 1997, vol. 128, pp. 19s-25s. |
Van B. Haywood, "Nightguard vital bleaching: current information and research", Esthetic Dentistry Update, 1990, vol. 1, No. 2, pp. 20-25. |
Van B. Haywood, "Response of normal and tetracycline-stained teeth with pulp-size variation to nightguard vital bleaching", Journal of Esthetic Dentistry, 1994, vol. 6, No. 3, pp. 109-114. |
Van B. Haywood, "The food and drug administration and its influence on home bleaching", ADA, 1993, pp. 12-18. |
Van B. Haywood, et al, "Nightguard vital bleaching, how safe is it?", Esthetic Dentistry, 1991, vol. 22, No. 7, pp. 515-523. |
Van Benjamin Haywood, "Overview and Status of Mouthguard Bleaching" Journal of Esthetic Dentistry, 1991, vol. 3, No. 5, pp. 157-161. |
Wikepedia, entry for "Silicone Resin", http://en.wikipedia.org/wiki/Silicone_resin, retrieved Nov. 25, 2006. * |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9889046B2 (en) | 2003-05-29 | 2018-02-13 | The Board Of Trustees Of The Leland Stanford Junior University | Skin treatment devices and methods with pre-stressed configurations |
US11246763B2 (en) | 2006-08-03 | 2022-02-15 | The Board Of Trustees Of The Leland Stanford Junior University | Skin treatment devices and methods with pre-stressed configurations |
US10857037B2 (en) | 2007-08-03 | 2020-12-08 | Neodyne Biosciences, Inc. | Controlled strain skin treatment devices and methods |
US9649226B2 (en) | 2007-08-03 | 2017-05-16 | Neodyne Biosciences, Inc. | Skin treatment devices with tensioning features |
US10420557B2 (en) | 2007-08-03 | 2019-09-24 | Neodyne Biosciences, Inc. | Skin straining devices and methods |
US10517768B2 (en) | 2007-08-03 | 2019-12-31 | Neodyne Biosciences, Inc. | Skin treatment devices with locking mechanisms |
US8647314B2 (en) * | 2008-03-15 | 2014-02-11 | Lts Lohmann Therapie-Systeme Ag | Gingival wafer |
US20110009834A1 (en) * | 2008-03-15 | 2011-01-13 | Lts Lohmann Therapie-Systeme Ag | Gingival wafer |
US20130281904A1 (en) * | 2010-08-11 | 2013-10-24 | Neodyne Biosciences, Inc. | Wound or skin treatment devices and methods |
US9844470B2 (en) * | 2010-08-11 | 2017-12-19 | Neodyne Biosciences, Inc. | Wound or skin treatment devices and methods |
US11013638B2 (en) | 2010-08-11 | 2021-05-25 | Neodyne Biosciences, Inc. | Wound or skin treatment devices and methods |
US11701262B2 (en) | 2011-03-03 | 2023-07-18 | Neodyne Biosciences, Inc. | Devices and methods for skin tightening |
US9205089B2 (en) | 2011-04-29 | 2015-12-08 | Massachusetts Institute Of Technology | Layer processing for pharmaceuticals |
USD733302S1 (en) * | 2014-03-11 | 2015-06-30 | Mdt Micro Diamond Technologies Ltd | Dental articulating device |
US10703048B2 (en) | 2014-05-20 | 2020-07-07 | Massachusetts Institute Of Technology | Plasticity induced bonding |
US10213960B2 (en) | 2014-05-20 | 2019-02-26 | Massachusetts Institute Of Technology | Plasticity induced bonding |
US11980738B1 (en) | 2019-12-10 | 2024-05-14 | Neodyne Biosciences, Inc. | Injection and infusion site treatment devices and methods |
US20230027167A1 (en) * | 2019-12-19 | 2023-01-26 | Lg Household & Health Care Ltd. | Patch attachable to teeth |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6649147B1 (en) | Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip | |
USRE42126E1 (en) | Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip | |
US6685921B2 (en) | Dental care compositions | |
US6569408B1 (en) | Compositions comprising organosiloxane resins for delivering oral care substances | |
US20070166244A1 (en) | Compositions comprising silicone pressure sensitive adhesives for delivering oral care substances | |
US6589512B1 (en) | Compositions comprising organosiloxane resins for delivering oral care substances | |
EP1328245B1 (en) | Dental care compositions | |
EP1196135B1 (en) | Compositions comprising organosiloxane resins for delivering oral care substances | |
EP1196136B1 (en) | Compositions comprising organosiloxane resins for delivering oral care substances | |
US6692727B1 (en) | Systems comprising organosiloxane resins for delivering oral care substances and for prolonging such delivery | |
NZ516272A (en) | Compositions comprising organosiloxane resins for delivering oral care substances |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FEPP | Fee payment procedure |
Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
FPAY | Fee payment |
Year of fee payment: 8 |
|
REMI | Maintenance fee reminder mailed | ||
LAPS | Lapse for failure to pay maintenance fees |