USRE38074E1 - Contrast medium delivery system and associated method - Google Patents

Contrast medium delivery system and associated method Download PDF

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Publication number
USRE38074E1
USRE38074E1 US10/116,486 US11648602A USRE38074E US RE38074 E1 USRE38074 E1 US RE38074E1 US 11648602 A US11648602 A US 11648602A US RE38074 E USRE38074 E US RE38074E
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check valve
inlet
outlet port
stopcock
fluid flow
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US10/116,486
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Daniel K. Recinella
Eamonn Hobbs
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AngioDynamics Inc
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AngioDynamics Inc
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Priority to US08/966,671 priority patent/US6315762B1/en
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Assigned to JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT reassignment JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT SECURITY AGREEMENT Assignors: ANGIODYNAMICS, INC.
Assigned to ANGIODYNAMICS, INC. reassignment ANGIODYNAMICS, INC. RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: JPMORGAN CHASE BANK N.A., AS ADMINISTRATIVE AGENT
Assigned to JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT reassignment JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ANGIODYNAMICS, INC.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/007Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media

Abstract

A device cooperating with a pump for guiding a contrast medium from a source thereof to a catheter for delivery to a patient's vascular system. The device comprises a dual check valve, a tubular member, an in-line check valve and a three-port stopcock. The dual check valve has an inlet port connectable to the source of contrast medium, an inlet-outlet port connectable to the pump, and an outlet port coupled to the tubular member. The in-line check valve is connected to the tubular member at a point spaced from the dual check valve for preventing fluid flow towards the dual check valve. The stopcock connected at a first port to the in-line check valve, a second port of the stopcock being operatively connectable to the catheter. Using this device, medical personnel infuses contrast medium into the patient from the source without having to disconnect any element from the device during the infusion process.

Description

CROSS-REFERENCE TO A RELATED APPLICATION

This application relies for priority purposes on U.S. provisional application No. 60/031,116 filed Nov. 14, 1996.

BACKGROUND OF THE INVENTION

This invention relates to a device and a system for delivering contrast medium to a patient. The device and system are especially effective for delivering carbon dioxide gas to the vascular system of a patient. This invention also relates to an associated method for delivering contrast medium such as carbon dioxide gas to a patient.

Delivery systems for contrast media have been used for many years in the medical field. Keeping the system a “closed system” so that no room air will be introduced is critical to the features of these delivery systems. With the advent of carbon dioxide gas or CO2 as a viable fluid for displacing blood in vessels for visualization under Digital Subtraction Angiography (DSA), the need to keep air out of the system is of even greater importance. Air and CO2 are invisible so introduction of air into a CO2 delivery system would pose a danger to a patient if it were inadvertently injected into the vasculature.

CO2 has been shown to be an excellent fluid to be used for displacing blood in vessels. This void that is created in the vessel can be visualized with DSA. But since CO2 is invisible introduction of room air into the system would pose a great danger to the patient. The air would go undetected and, once in the patient's vasculature, could cause a blockage or even an air embolism to the brain resulting in a stroke or death.

Because of this serious safety issue, it would make sense to use a closed system for the safe delivery of CO2. However, the conventional method used for delivering CO2 is connecting a syringe to a CO2 cylinder, filling the syringe with CO2, disconnecting the syringe from the cylinder and re-connecting to a catheter or tube set. If more CO2 is needed, the syringe is disconnected from the catheter and refilled of the cylinder. This method allows for introduction of air into the system at every disconnection.

One method that was developed to reduce the number of disconnections was to attach the CO2 cylinder directly to a stopcock with a syringe attached at on port and the catheter to the patient attached to the other port. When the syringe was to be filled, the stopcock would be opened to the syringe and the cylinder pressure would force CO2 into the syringe. For injection into the patient, the stopcock would be closed to the cylinder and the syringe plunger would be advanced forward pushing the CO2 gas into the catheter and, subsequently, into the patient.

The problem with this method is that the CO2 cylinder pressure is much higher than blood pressure (830 psi vs. 6 psi). If the stopcock is turned the wrong way, the cylinder is open to the catheter and liters of CO2 will be delivered into the patient in less than a minute. Accordingly, the cylinder must be isolated from the patient and the delivery system used must be closed without providing a chance for the introduction of air.

BRIEF DESCRIPTION

It is an object of the invention to provide an improved device or system for delivering contrast medium to a patient's vascular system.

Another object of the present invention is to provide such a device or system wherein air can be effectively eliminated prior to the feeding of the contrast medium to the patient.

It is a further object of the present invention to provide such a device or system wherein highly pressurized sources of contrast medium are isolated from the patient to prevent chance introduction of excessive amounts of contrast medium into the patient.

An additional object of the present invention is to provide such a device or system wherein explosive introduction of gaseous contrast medium (carbon dioxide) into the patient can be minimized or eliminated.

Yet another object of the present invention is to provide such a device or system which is inexpensive and made of essentially off-the-shelf components.

A related object of the present invention is to provide an associated method for infusing contrast medium into a patient's vascular system.

These and other objects of the present invention are attained in a device cooperating with a pump for guiding a contrast medium from a source thereof to a catheter for delivery to a patient's vascular system. The device comprises a dual check valve, a tubular member, an in-line check valve and a three-port stopcock. The dual check valve has an inlet port connectable to the source of contrast medium, an inlet-outlet port connectable to the pump, and an outlet port coupled to the tubular member. The in-line check valve is connected to the tubular member at a point spaced from the dual check valve for preventing fluid flow towards the dual check valve. The stopcock connected at a first port to the in-line check valve, a second port of the stopcock being operatively connectable to the catheter.

Using this device, medical personnel may infuse contrast medium into the patient from the source without having to disconnect any element from the device during the infusion process. The entire system, including the source, the device, the pump and the catheter, is purged of air prior to beginning the infusion and air cannot be reintroduced back into the system during the infusion. The dual check valve permits continued connection of the pump to the system. Thus, where the pump takes the form of a syringe, the pump need not be disconnected from the system between an intake stroke and an ejection stroke of the syringe plunger. The in-line check valve prevents flow of blood from the catheter into the tubular member. It is contemplated that the dual check valve, the syringe and the tubular member are first purged of air by directing contrast medium through those parts of the system and out a third port of the stopcock, and subsequently the catheter, which is connected to the second port of the stopcock, is purged of air by allowing the patient's blood to flow through the catheter and out the third port of the stopcock.

According to another feature of the present invention, the in-line check valve is a dual check valve having an additional inlet port connected to the tubular member, an additional outlet port connected to the stopcock, and an additional inlet-outlet port operatively connectable to an ancillary pump such as a syringe. An additional stopcock may be disposed between the ancillary pump and the additional inlet-outlet port.

This additional structure facilitates a clearing of the catheter of blood prior to infusion of the contrast medium into the patient. The ancillary syringe has a limited volume not significantly greater than the volume in a path extending through the in-line check valve, the stopcock and the catheter. The ancillary syringe is operated to draw contrast medium from the source through the first dual check valve and then to drive the contrast medium through the catheter but not substantially into the patient. The system is now ready for the controlled infusion of contrast medium.

Preferably, the dual check valve, the tubular member, the in-line check valve and the stopcock are all permanently bonded to one another. This prevents the air leakage into the system.

In accordance with another feature of the present invention, the source of contrast medium is a flexible bag. A method for supplying a contrast medium to a patient's vascular system thus comprises operatively connecting the flexible bag to the patient's vascular system via a gas transfer system, purging the gas transfer system of air, and thereafter delivering contrast medium from the flexible bag through the gas transfer system to the patient's vascular system.

The flexible bag contains contrast medium at ambient atmospheric pressure, thus preventing accidental infusion of contrast medium and particularly excessive amounts of contrast medium into the patient. Prior to connecting the flexible bag to the contrast-medium transfer device, the bag is filled multiple times with contrast medium and squeezed empty to clear the bag of air.

In a device or system in accordance with the present invention for delivering contrast medium to a patient's vascular system, air can be effectively eliminated prior to the feeding of the contrast medium to the patient. Highly pressurized sources of contrast medium are isolated from the patient, thereby preventing inadvertent introduction of excessive amounts of contrast medium into the patient. Also, explosive introduction of gaseous contrast medium (carbon dioxide) into the patient can be minimized or eliminated.

BRIEF DESCRIPTION OF THE DRAWING

FIG. 1 is a schematic elevational view of a system for controllably infusing carbon dioxide contrast medium into a patient's vascular system, in accordance with the present invention.

FIG. 2 is a schematic elevational view of a modified system in accordance with the present invention.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

As illustrated in FIG. 1, a system for controllably infusing carbon dioxide contrast medium into a patient's vasculature comprises a flexible reservoir bag 11, a one-way reservoir bag stopcock 12, a delivery syringe 13, a dual check valve 14, an in-line check valve 15, a distal one-way stopcock 16, a purge syringe 17, a connecting tube 22, and a patient stopcock 23. This system will remove the high-pressure CO2 cylinder from the vicinity of the patient and maintain a closed system that reduce or eliminate the chance introduction of air into the patient's vasculature.

Reservoir bag 11 is made of a soft elastomeric, non-porous material. When bag 11 is filled to its capacity or just under capacity (500-2000 ml), the bag is at ambient atmospheric pressure. Therefore, bag 11 will not have a tendency to deliver CO2 gas into the patient even if the bag is coupled directly to the patient's vasculature. The patient's blood pressure will be higher than the pressure of the bag. The use of flexible reservoir bag 11 acts as a safety feature for two reasons. First, there is no pressurized source of CO2 gas placed in communication with the patient. Second, bag 11 provides a large reservoir of CO2 so that numerous connections and disconnections are obviated.

Dual check valve 14 is permanently bonded to tube 22. Tube 22 is permanently bonded to in-line check valve 15. In-line check valve 15 is permanently bonded to patient stopcock 23 and distal stopcock 16. Every component in the system except syringes 13 and 17, including dual check valve 14, tube 22, in-line check valve 15, and stopcocks 16 and 23, can withstand pressures from ambient to 1200 psi. Therefore, this system could be used with high pressure injectors, as well as with bag 11.

The system of FIG. 1 is used as follows.

Reservoir bag 11 is coupled to a CO2 cylinder (not illustrated) via a connecting tube 35 and reservoir bag stopcock 12. The cylinder contains 99.7% pure medical grade carbon dioxide and is equipped with a two-stage gas regulator (not shown), a filter (not shown) to remove sub-micron particles, and a Luer-Lok fitting (not shown) to which reservoir bag 11 is coupled. Bag 11 is filled with CO2 gas, disconnected from the cylinder and squeezed until the bag is empty. Bag 11 is then connected to the CO2 cylinder again and re-filled. This process is repeated two to three times to ensure that all the air has been removed from reservoir bag 11. On the last filling, bag 11 is filled and reservoir stopcock 12 is closed. Bag 11 is then detached from the CO2 cylinder and connected to a side or inlet port 24 of dual check valve 14 via a Luer-Lok fitting 36. Inlet port 24 contains a one-way valve 19 which permits fluid to enter the dual check valve 14 through that port but prevents fluid from flowing out of check valve 14. Delivery syringe 13, a Luer-Lok syringe or mechanical injector syringe, is attached to a side or inlet-outlet port 25 of dual check valve 14 and purge syringe 17 is attached to distal stopcock 16.

With all components attached, reservoir stopcock 12 is opened. The plunger 26 of delivery syringe 13 is drawn back, aspirating CO2 gas into the syringe. When plunger 26 is drawn, a one-way valve element 18 in an outlet port 27 of dual check valve 14 closes and does not allow any flow from downstream into the check valve 14. One-way check valve 19 opens and permits fluid flow from reservoir bag 11 into delivery syringe 13.

When plunger 26 of delivery syringe 13 is advanced forward in a pressure stroke, one-way valve element 19 closes and one-way valve element 18 opens, thereby permitting CO2 gas to flow down the tube 22 and out an open port 28 of patient stopcock 13 at the end of the system. By executing this procedure two or three times, the user purges delivery syringe 13, dual check valve 14, tube 22 and in-line check valve 15 of all room air so that only CO2 gas is present in those components of the system.

Purge syringe 17 and distal stopcock 16 are purged next. Upon the opening of distal stopcock 16, purge syringe 17 can draw CO2 gas through check valve 15 and tube 22. A plunger 29 of purge syringe 17 is drawn back. With that action, one-way check valves 18 and 19 of dual check valve 14 and a one-way valve element 20 of in-line check valve 15 are open and allow gas from reservoir bag 11 to flow into purge syringe 17. Another one-way valve element 21 of in-line check valve 15 closes to keep air out of the system. When plunger 29 of purge syringe 17 is depressed in a pressure stroke, the CO2 gas moves forward. One-way valve element 20 closes and one-way valve element 21 opens, thereby permitting CO2 gas to flow out through port 28 at the end of the system. The performance of this action two or three times serves to remove any air contained in in-line check valve 15 and patient stopcock 23.

The above-described priming procedure takes only a few minutes. Once all the air has been removed from the system, a port 28 of patient stopcock 23 is attached to a catheter 32. Blood can be drawn through side port 30 of patient stopcock 23, assuring that all air has been removed from the catheter. When patient stopcock 23 is closed to side port 30, the system is totally closed and room air cannot enter. One-way valve element 21 of dual in-line check valve 15 keeps blood from flowing upstream along tube 22 towards dual check valve 14.

When a CO2 infusion procedure is being performed, it is important to reduce the resistance to gas flow in catheter 32 as much as possible. If the resistance is too high, the gas can build up pressure and exit the catheter explosively. This can result in pain for the patient and inconsistent imaging.

The best way to reduce the resistance is to remove the liquid (saline or blood) that is in catheter 32. This liquid will pose the most significant resistance problems to CO2 flow. To perform a liquid removal procedure, distal stopcock 16 is opened and a limited aliquot (e.g., 3-5 ml) of CO2 is drawn into purge syringe 17. Plunger 29 of purge syringe 17 is subsequently advanced in a pressure stroke. During this pressure stroke, one-way valve element 20 of in-line check valve 15 closes and one-way valve element 21 opens. CO2 gas flows through patient stopcock 23 into catheter 32. This small amount of CO2 displaces the blood or other liquid that is in catheter 32, thereby generating a gas path which is lower in resistance to flow than the patient's blood. One-way valve element 21 of in-line check valve 15 closes from the back pressure of the CO2 gas in catheter 32, thus making it difficult for blood to flow back into catheter 32.

To infuse carbon dioxide into a patient, plunger 26 of delivery syringe 13 is drawn back. One-way check valve element 18 closes and one-way check valve element 19 opens, allowing flow from reservoir bag 11 into delivery syringe 13. Distal stopcock 16 is closed. Plunger 26 of the delivery syringe 13 is advanced in a pressure stroke and the gas is injected into the patient through one-way check valve element 18, tube 22, in-line check valve 15, patient stopcock 23 and catheter 32. For another injection, the retraction and advancing of plunger 26 are repeated. The user can continue until all the CO2 in reservoir bag 11 is used, without having to disconnect any of the elements, e.g., syringe 13, from the system.

FIG. 2 shows a modified design in which in-line check valve 15 has been replaced with an in-line check valve in the form of a single one-way valve 34 and in which stopcock 16 and purge syringe 17 have been removed. The advantage to this design is that there is one less connection so the system becomes even more safe to use. The purge of the liquid from the catheter is done using delivery syringe 13.

While the invention has been described in connection with what is presently considered to be the most practical and preferred embodiments, it is to be understood that the invention is not to be limited to the disclosed embodiment, but on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims.

Claims (15)

What is claimed is:
1. A system for delivering contrast medium at low pressure to a catheter for delivery to a patient's vascular system comprising:
 a dual check valve adapted to be connected to a lower pressure source of contrast medium, said dual check valve having an inlet port, an outlet port and an inlet-outlet port,
said dual check valve containing a first one-way valve at said inlet port automatically responsive to the relatively low pressure at said inlet-outlet port to permit down-stream fluid flow and to prevent upstream fluid flow,
said dual check valve containing a second one-way valve at said outlet port automatically responsive to the relatively high pressure at said inlet-outlet port to permit downstream fluid flow and to prevent upstream fluid flow,
said inlet-outlet port in communication with said first and second one-way valves and adapted to be connected to
a pump,
a connecting tubular member having an upstream and a downstream end, said upstream end in communication with said outlet port of said dual check valve,
suction at said inlet-outlet port by a the pump causing flow of medium from whatever source is coupled to said inlet port through said first one-way valve into the pump, said second one-way valve preventing fluid flow upstream from said connecting tubular member into the pump,
positive pressure at said inlet-outlet port from a the pump causing fluid flow through said second one-way valve and said outlet port into said tubular member, said first one-way valve preventing upstream fluid flow to a the source, and
a third one-way valve in communication with said down-stream end of said tubular member to permit down-stream fluid flow from said tubular member and to prevent upstream fluid flow into said tubular member.
2. The system of claim 1 further comprising:
a first stopcock upstream of said inlet port of said dual check valve to turn flow from a the source on and off.
3. The system of claim 1 further comprising:
a second stopcock downstream of said third one-way valve to turn flow into a the catheter on and off.
4. The system of claim 2 further comprising:
a second stopcock downstream of said third one-way valve to turn flow into a the catheter on and off.
5. The system of claim 1 further comprising:
a second dual check valve downstream of said down-stream end of said tubular member and incorporating said third one-way valve,
said second dual check valve having a second inlet-outlet port adapted to be connected to an ancillary pump,
said second dual check valve having a fourth one-way valve in communication with said second inlet-outlet port to permit downstream fluid flow from an the ancillary pump, said third one-way valve preventing upstream fluid flow from an the ancillary pump.
6. The system of claim 5 further comprising:
a first stopcock upstream of said inlet port of said dual check valve to turn flow from a the source on and off.
7. The system of claim 5 further comprising:
a second stopcock downstream of said second dual check valve to turn flow into a the catheter on and off.
8. The system of claim 6 further comprising:
a second stopcock downstream of said second dual check valve to turn flow into a the catheter on and off.
9. An apparatus for delivering contrast medium at low pressure to a catheter for delivery to a patient's vascular system comprising:
a dual check valve adapted to be connected to a lower pressure source of contrast medium, said dual check valve having a first inlet port, a first outlet port and a first inlet-outlet port,
said dual check valve containing a first one-way valve at said first inlet port automatically responsive to the relatively low pressure at said first inlet-outlet port to permit downstream fluid flow and to prevent upstream fluid flow,
said dual check valve containing a second one-way valve at said first outlet port automatically responsive to the relatively high pressure at said first inlet-outlet port to permit downstream fluid flow and to prevent upstream fluid flow,
said first inlet-outlet port in communication with said first and second one-way valves and adapted to be connected to a pump,
a connecting tubular member having an upstream and a downstream end, said upstream end in communication with said first outlet port of said dual check valve,
suction at said first inlet-outlet port by the pump causing flow of medium from whatever source is coupled to said first inlet port through said first one-way valve into the pump, said second one-way valve preventing fluid flow upstream from said connecting tubular member into the pump, and
positive pressure at said first inlet-outlet port from the pump causing fluid flow through said second one-way valve and said first outlet port into said tubular member, said first one-way valve preventing upstream fluid flow to the source.
10. The apparatus of claim 11 further comprising:
a first stopcock upstream of said first inlet port of said dual check valve to turn flow from the source on and off.
11. The apparatus of claim 10 further comprising:
a second stopcock on said downstream end of said tubular member to turn flow into the catheter on and off.
12. The apparatus of claim 9 further comprising:
a stopcock on said downstream end of said tubular member to turn flow into the catheter on and off.
13. The apparatus of claim 9 further comprising:
an in-line check valve connected to said downstream end of said tubular member, wherein said in-line check valve has a second inlet port in which said tubular member is connected, a second inlet-outlet port adapted to be connected to an ancillary pump, and a second outlet port connected to a first stopcock which is connected to the catheter.
14. The apparatus of claim 13 further comprising:
a second stopcock upstream of said first inlet port of said dual check valve to turn flow from the source on and off.
15. The apparatus of claim 14 further comprising:
a third stopcock disposed between the ancillary pump and the second inlet-outlet port downstream said in-line check valve to turn flow into the catheter on and off.
US10/116,486 1996-11-14 2002-04-03 Contrast medium delivery system and associated method Expired - Lifetime USRE38074E1 (en)

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US08/966,671 US6315762B1 (en) 1996-11-14 1997-11-10 Contrast medium delivery system and associated method
US10/116,486 USRE38074E1 (en) 1996-11-14 2002-04-03 Contrast medium delivery system and associated method

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Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020143300A1 (en) * 1998-01-29 2002-10-03 Trombley Frederick W. Fluid delivery system and an aseptic connector for use therewith
US20050145258A1 (en) * 2004-01-05 2005-07-07 Yonghua Dong Composition, Method and Device for Blood Supply Fluctuation Therapy
US20060178632A1 (en) * 2000-10-18 2006-08-10 Trombley Frederick W Iii Injector system with a manual control device
US20070119508A1 (en) * 2005-11-29 2007-05-31 West Richard L Fluid Flow Diversion Valve and Blood Collection System Employing Same
US7513890B2 (en) 2003-05-06 2009-04-07 Navilyst Medical, Inc. Fluid manifold control device
US20090099552A1 (en) * 2007-10-12 2009-04-16 Maureen Levy Drug delivery route-based connector system and method
US20090143731A1 (en) * 2007-11-29 2009-06-04 Guzman Michael F Method and apparatus for charging pump with local anesthetic
WO2009073434A1 (en) * 2007-11-29 2009-06-11 Guzman Michael F Pain management methods and apparatus
US20090218535A1 (en) * 2008-02-27 2009-09-03 Andres Pasko Flow controllers for fluid circuits
US7766883B2 (en) 2007-10-30 2010-08-03 Medrad, Inc. System and method for proportional mixing and continuous delivery of fluids
US7785302B2 (en) 2005-03-04 2010-08-31 C. R. Bard, Inc. Access port identification systems and methods
US7947022B2 (en) 2005-03-04 2011-05-24 C. R. Bard, Inc. Access port identification systems and methods
US8025639B2 (en) 2005-04-27 2011-09-27 C. R. Bard, Inc. Methods of power injecting a fluid through an access port
US8029482B2 (en) 2005-03-04 2011-10-04 C. R. Bard, Inc. Systems and methods for radiographically identifying an access port
US8177762B2 (en) 1998-12-07 2012-05-15 C. R. Bard, Inc. Septum including at least one identifiable feature, access ports including same, and related methods
US8202259B2 (en) 2005-03-04 2012-06-19 C. R. Bard, Inc. Systems and methods for identifying an access port
US8257325B2 (en) 2007-06-20 2012-09-04 Medical Components, Inc. Venous access port with molded and/or radiopaque indicia
US8328787B2 (en) 2007-11-29 2012-12-11 Guzman Michael F Pain management methods and apparatus
USD676955S1 (en) 2010-12-30 2013-02-26 C. R. Bard, Inc. Implantable access port
USD682416S1 (en) 2010-12-30 2013-05-14 C. R. Bard, Inc. Implantable access port
US8641676B2 (en) 2005-04-27 2014-02-04 C. R. Bard, Inc. Infusion apparatuses and methods of use
US8715244B2 (en) 2009-07-07 2014-05-06 C. R. Bard, Inc. Extensible internal bolster for a medical device
US8932271B2 (en) 2008-11-13 2015-01-13 C. R. Bard, Inc. Implantable medical devices including septum-based indicators
US9011377B2 (en) 2008-11-05 2015-04-21 Bayer Medical Care Inc. Fluid mixing control device for a multi-fluid delivery system
US9079004B2 (en) 2009-11-17 2015-07-14 C. R. Bard, Inc. Overmolded access port including anchoring and identification features
US9265912B2 (en) 2006-11-08 2016-02-23 C. R. Bard, Inc. Indicia informative of characteristics of insertable medical devices
US9433730B2 (en) 2013-03-14 2016-09-06 Bayer Healthcare Llc Fluid mixing control device for a multi-fluid delivery system
US9474888B2 (en) 2005-03-04 2016-10-25 C. R. Bard, Inc. Implantable access port including a sandwiched radiopaque insert
US9517329B2 (en) 2007-07-19 2016-12-13 Medical Components, Inc. Venous access port assembly with X-ray discernable indicia
US9579496B2 (en) 2007-11-07 2017-02-28 C. R. Bard, Inc. Radiopaque and septum-based indicators for a multi-lumen implantable port
US9610432B2 (en) 2007-07-19 2017-04-04 Innovative Medical Devices, Llc Venous access port assembly with X-ray discernable indicia
US9642986B2 (en) 2006-11-08 2017-05-09 C. R. Bard, Inc. Resource information key for an insertable medical device
US9700672B2 (en) 2011-09-21 2017-07-11 Bayer Healthcare Llc Continuous multi-fluid pump device, drive and actuating system and method
US9956377B2 (en) 2002-09-20 2018-05-01 Angiodynamics, Inc. Method and apparatus for intra-aortic substance delivery to a branch vessel
US10279112B2 (en) 2012-09-24 2019-05-07 Angiodynamics, Inc. Power injector device and method of use
US10307581B2 (en) 2005-04-27 2019-06-04 C. R. Bard, Inc. Reinforced septum for an implantable medical device

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6315762B1 (en) * 1996-11-14 2001-11-13 Angiodynamics, Inc. Contrast medium delivery system and associated method
ES2162573B1 (en) * 1999-08-04 2002-08-01 Probitas Pharma Sa Angiografia apparatus co2 injection.
US6500156B1 (en) * 2000-10-03 2002-12-31 Mckinley Medical L.L.L.P Thumb-powered flushing device for catheters
JP2004065737A (en) * 2002-08-08 2004-03-04 Nemoto Kyorindo:Kk Liquid chemical injecting apparatus
US20060097013A1 (en) * 2003-04-28 2006-05-11 Bargh Adrian N Dispenser
US8048086B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US20080033366A1 (en) * 2006-01-30 2008-02-07 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
US10149935B2 (en) 2006-11-27 2018-12-11 Frank Levy Delivery system and method for the effective and reliable delivery of controlled amounts of a medical fluid
US9662435B2 (en) 2006-01-31 2017-05-30 Frank Levy System and method for the effective, reliable and foolproof delivery of controlled amounts of a medical fluid
US20070181157A1 (en) * 2006-02-07 2007-08-09 Dadourian Daniel G Apparatus and methods for flushing medical devices
US20070282297A1 (en) * 2006-06-01 2007-12-06 Knight Thomas F System and method for safely infusing toxins using extension set, connect set and cyto admin set
US10155093B2 (en) 2006-11-27 2018-12-18 Frank Levy Apparatus and method for producing CO2 enriched medical foam
US9427522B2 (en) 2006-11-27 2016-08-30 Frank Levy Delivery system for the effective and reliable delivery of controlled amounts of a medical fluid
US10350399B2 (en) 2006-11-27 2019-07-16 Frank Levy Apparatus and method for producing an enriched medical suspension of carbon dioxide
US10322271B2 (en) 2006-11-27 2019-06-18 Frank Levy Delivery system and method for the effective and reliable delivery of controlled amounts of a medical fluid
CA2602107A1 (en) * 2007-09-13 2009-03-13 Carsten Stevenson Method of injecting carbon dioxide into a vascular structure and system for practising the method
US9554826B2 (en) 2008-10-03 2017-01-31 Femasys, Inc. Contrast agent injection system for sonographic imaging
US10070888B2 (en) 2008-10-03 2018-09-11 Femasys, Inc. Methods and devices for sonographic imaging
IT1398604B1 (en) * 2009-11-23 2013-03-08 Spark S R L Device for dosing and regulating the flow of a contrast medium for the execution of angiograms
EP2506889B1 (en) 2009-12-03 2018-06-13 Jean-Pierre Peters Fluid interconnection set with particle filter
US9050401B2 (en) * 2010-05-19 2015-06-09 Angioadvancements, Llc System for controlled delivery of medical fluids
US9155831B2 (en) 2010-08-04 2015-10-13 University Of Florida Research Foundation, Inc. Apparatuses and methods for detecting gas contamination
WO2012106613A1 (en) * 2011-02-04 2012-08-09 Merit Medical Systems, Inc. Gas adaptor and method of use
JP6071880B2 (en) * 2011-07-14 2017-02-01 株式会社根本杏林堂 Medical liquid circuit kit and liquid circuit system using the same
FR2991881B1 (en) * 2012-06-13 2014-09-05 Medex Sa Device for injecting a liquid product comprising two mobile half-shells in rotation in relation to each other

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250034A (en) * 1990-09-17 1993-10-05 E-Z-Em, Inc. Pressure responsive valve catheter
US5267979A (en) * 1990-09-17 1993-12-07 E-Z-Em, Inc. Pressure responsive valve catheter
US5569208A (en) * 1995-08-01 1996-10-29 Merit Medical Systems, Inc. System for managing delivery of contrast media
US5575767A (en) * 1994-09-16 1996-11-19 Stevens; Robert C. Method and apparatus for high pressure one-way fluid valving in angiography
US5651776A (en) * 1995-03-22 1997-07-29 Angiodynamics, Inc. Luer-type connector

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5249579A (en) * 1990-03-09 1993-10-05 E-Z-Em, Inc. Contrast media injector
US5322070A (en) * 1992-08-21 1994-06-21 E-Z-Em, Inc. Barium enema insufflation system
US5533978A (en) * 1994-11-07 1996-07-09 Teirstein; Paul S. Method and apparatus for uninterrupted delivery of radiographic dye
US5575779A (en) * 1994-12-30 1996-11-19 Namic U.S.A. Corporation Liquid regulator and method of use
US6315762B1 (en) * 1996-11-14 2001-11-13 Angiodynamics, Inc. Contrast medium delivery system and associated method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250034A (en) * 1990-09-17 1993-10-05 E-Z-Em, Inc. Pressure responsive valve catheter
US5267979A (en) * 1990-09-17 1993-12-07 E-Z-Em, Inc. Pressure responsive valve catheter
US5575767A (en) * 1994-09-16 1996-11-19 Stevens; Robert C. Method and apparatus for high pressure one-way fluid valving in angiography
US5651776A (en) * 1995-03-22 1997-07-29 Angiodynamics, Inc. Luer-type connector
US5569208A (en) * 1995-08-01 1996-10-29 Merit Medical Systems, Inc. System for managing delivery of contrast media

Cited By (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020143300A1 (en) * 1998-01-29 2002-10-03 Trombley Frederick W. Fluid delivery system and an aseptic connector for use therewith
US8608713B2 (en) 1998-12-07 2013-12-17 C. R. Bard, Inc. Septum feature for identification of an access port
US8177762B2 (en) 1998-12-07 2012-05-15 C. R. Bard, Inc. Septum including at least one identifiable feature, access ports including same, and related methods
US20060178632A1 (en) * 2000-10-18 2006-08-10 Trombley Frederick W Iii Injector system with a manual control device
US8747358B2 (en) 2000-10-18 2014-06-10 Bayer Medical Care Inc. Injector system with a manual control device
US9833559B2 (en) 2000-10-18 2017-12-05 Bayer Healthcare Llc Pressure isolation mechanisms, method of use thereof and fluid delivery systems including pressure isolation mechanisms
US9764081B2 (en) 2000-10-18 2017-09-19 Bayer Healthcare Llc Fluid path containing a pressure isolation valve
US9956377B2 (en) 2002-09-20 2018-05-01 Angiodynamics, Inc. Method and apparatus for intra-aortic substance delivery to a branch vessel
US20090198209A1 (en) * 2003-05-06 2009-08-06 Kathryn Mary Usher Fluid manifold control device
US7513890B2 (en) 2003-05-06 2009-04-07 Navilyst Medical, Inc. Fluid manifold control device
US20050145258A1 (en) * 2004-01-05 2005-07-07 Yonghua Dong Composition, Method and Device for Blood Supply Fluctuation Therapy
US8585663B2 (en) 2005-03-04 2013-11-19 C. R. Bard, Inc. Access port identification systems and methods
US9474888B2 (en) 2005-03-04 2016-10-25 C. R. Bard, Inc. Implantable access port including a sandwiched radiopaque insert
US7947022B2 (en) 2005-03-04 2011-05-24 C. R. Bard, Inc. Access port identification systems and methods
US7959615B2 (en) 2005-03-04 2011-06-14 C. R. Bard, Inc. Access port identification systems and methods
US7785302B2 (en) 2005-03-04 2010-08-31 C. R. Bard, Inc. Access port identification systems and methods
US8029482B2 (en) 2005-03-04 2011-10-04 C. R. Bard, Inc. Systems and methods for radiographically identifying an access port
US10179230B2 (en) 2005-03-04 2019-01-15 Bard Peripheral Vascular, Inc. Systems and methods for radiographically identifying an access port
US8603052B2 (en) 2005-03-04 2013-12-10 C. R. Bard, Inc. Access port identification systems and methods
US8202259B2 (en) 2005-03-04 2012-06-19 C. R. Bard, Inc. Systems and methods for identifying an access port
US10238850B2 (en) 2005-03-04 2019-03-26 Bard Peripheral Vascular, Inc. Systems and methods for radiographically identifying an access port
US10265512B2 (en) 2005-03-04 2019-04-23 Bard Peripheral Vascular, Inc. Implantable access port including a sandwiched radiopaque insert
US9682186B2 (en) 2005-03-04 2017-06-20 C. R. Bard, Inc. Access port identification systems and methods
US8382723B2 (en) 2005-03-04 2013-02-26 C. R. Bard, Inc. Access port identification systems and methods
US9603992B2 (en) 2005-03-04 2017-03-28 C. R. Bard, Inc. Access port identification systems and methods
US8382724B2 (en) 2005-03-04 2013-02-26 C. R. Bard, Inc. Systems and methods for radiographically identifying an access port
US9603993B2 (en) 2005-03-04 2017-03-28 C. R. Bard, Inc. Access port identification systems and methods
US8998860B2 (en) 2005-03-04 2015-04-07 C. R. Bard, Inc. Systems and methods for identifying an access port
US8939947B2 (en) 2005-03-04 2015-01-27 C. R. Bard, Inc. Systems and methods for radiographically identifying an access port
US8545460B2 (en) 2005-04-27 2013-10-01 C. R. Bard, Inc. Infusion apparatuses and related methods
US8475417B2 (en) 2005-04-27 2013-07-02 C. R. Bard, Inc. Assemblies for identifying a power injectable access port
US9937337B2 (en) 2005-04-27 2018-04-10 C. R. Bard, Inc. Assemblies for identifying a power injectable access port
US8025639B2 (en) 2005-04-27 2011-09-27 C. R. Bard, Inc. Methods of power injecting a fluid through an access port
US8641688B2 (en) 2005-04-27 2014-02-04 C. R. Bard, Inc. Assemblies for identifying a power injectable access port
US10016585B2 (en) 2005-04-27 2018-07-10 Bard Peripheral Vascular, Inc. Assemblies for identifying a power injectable access port
US10052470B2 (en) 2005-04-27 2018-08-21 Bard Peripheral Vascular, Inc. Assemblies for identifying a power injectable access port
US8805478B2 (en) 2005-04-27 2014-08-12 C. R. Bard, Inc. Methods of performing a power injection procedure including identifying features of a subcutaneously implanted access port for delivery of contrast media
US9421352B2 (en) 2005-04-27 2016-08-23 C. R. Bard, Inc. Infusion apparatuses and methods of use
US10183157B2 (en) 2005-04-27 2019-01-22 Bard Peripheral Vascular, Inc. Assemblies for identifying a power injectable access port
US8641676B2 (en) 2005-04-27 2014-02-04 C. R. Bard, Inc. Infusion apparatuses and methods of use
US10307581B2 (en) 2005-04-27 2019-06-04 C. R. Bard, Inc. Reinforced septum for an implantable medical device
US20070119508A1 (en) * 2005-11-29 2007-05-31 West Richard L Fluid Flow Diversion Valve and Blood Collection System Employing Same
US9642986B2 (en) 2006-11-08 2017-05-09 C. R. Bard, Inc. Resource information key for an insertable medical device
US10092725B2 (en) 2006-11-08 2018-10-09 C. R. Bard, Inc. Resource information key for an insertable medical device
US9265912B2 (en) 2006-11-08 2016-02-23 C. R. Bard, Inc. Indicia informative of characteristics of insertable medical devices
US9533133B2 (en) 2007-06-20 2017-01-03 Medical Components, Inc. Venous access port with molded and/or radiopaque indicia
US8852160B2 (en) 2007-06-20 2014-10-07 Medical Components, Inc. Venous access port with molded and/or radiopaque indicia
US8257325B2 (en) 2007-06-20 2012-09-04 Medical Components, Inc. Venous access port with molded and/or radiopaque indicia
US9610432B2 (en) 2007-07-19 2017-04-04 Innovative Medical Devices, Llc Venous access port assembly with X-ray discernable indicia
US9517329B2 (en) 2007-07-19 2016-12-13 Medical Components, Inc. Venous access port assembly with X-ray discernable indicia
US20090099552A1 (en) * 2007-10-12 2009-04-16 Maureen Levy Drug delivery route-based connector system and method
USRE45717E1 (en) 2007-10-30 2015-10-06 Bayer Medical Care Inc. System and method for proportional mixing and continuous delivery of fluids
US20100298699A1 (en) * 2007-10-30 2010-11-25 Medrad Inc. System and Method for Proportional Mixing and Continuous Delivery of Fluids
US8162903B2 (en) 2007-10-30 2012-04-24 Medrad, Inc. System and method for proportional mixing and continuous delivery of fluids
US7766883B2 (en) 2007-10-30 2010-08-03 Medrad, Inc. System and method for proportional mixing and continuous delivery of fluids
US9579496B2 (en) 2007-11-07 2017-02-28 C. R. Bard, Inc. Radiopaque and septum-based indicators for a multi-lumen implantable port
US10086186B2 (en) 2007-11-07 2018-10-02 C. R. Bard, Inc. Radiopaque and septum-based indicators for a multi-lumen implantable port
US8328787B2 (en) 2007-11-29 2012-12-11 Guzman Michael F Pain management methods and apparatus
WO2009073434A1 (en) * 2007-11-29 2009-06-11 Guzman Michael F Pain management methods and apparatus
US8211091B2 (en) 2007-11-29 2012-07-03 Guzman Michael F Method and apparatus for charging pump with local anesthetic
US20090143731A1 (en) * 2007-11-29 2009-06-04 Guzman Michael F Method and apparatus for charging pump with local anesthetic
US20090218535A1 (en) * 2008-02-27 2009-09-03 Andres Pasko Flow controllers for fluid circuits
US9011377B2 (en) 2008-11-05 2015-04-21 Bayer Medical Care Inc. Fluid mixing control device for a multi-fluid delivery system
US9861742B2 (en) 2008-11-05 2018-01-09 Bayer Healthcare Llc Fluid mixing control device for a multi-fluid delivery system
US10052471B2 (en) 2008-11-13 2018-08-21 C. R. Bard, Inc. Implantable medical devices including septum-based indicators
US8932271B2 (en) 2008-11-13 2015-01-13 C. R. Bard, Inc. Implantable medical devices including septum-based indicators
US8715244B2 (en) 2009-07-07 2014-05-06 C. R. Bard, Inc. Extensible internal bolster for a medical device
US9248268B2 (en) 2009-11-17 2016-02-02 C. R. Bard, Inc. Overmolded access port including anchoring and identification features
US9079004B2 (en) 2009-11-17 2015-07-14 C. R. Bard, Inc. Overmolded access port including anchoring and identification features
US10155101B2 (en) 2009-11-17 2018-12-18 Bard Peripheral Vascular, Inc. Overmolded access port including anchoring and identification features
US9717895B2 (en) 2009-11-17 2017-08-01 C. R. Bard, Inc. Overmolded access port including anchoring and identification features
USD682416S1 (en) 2010-12-30 2013-05-14 C. R. Bard, Inc. Implantable access port
USD676955S1 (en) 2010-12-30 2013-02-26 C. R. Bard, Inc. Implantable access port
US9700672B2 (en) 2011-09-21 2017-07-11 Bayer Healthcare Llc Continuous multi-fluid pump device, drive and actuating system and method
US10279112B2 (en) 2012-09-24 2019-05-07 Angiodynamics, Inc. Power injector device and method of use
US9433730B2 (en) 2013-03-14 2016-09-06 Bayer Healthcare Llc Fluid mixing control device for a multi-fluid delivery system

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US6315762B1 (en) 2001-11-13

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