USRE24573E - Acid neutralizing abrasive chlorophyll - Google Patents
Acid neutralizing abrasive chlorophyll Download PDFInfo
- Publication number
- USRE24573E USRE24573E US24573DE USRE24573E US RE24573 E USRE24573 E US RE24573E US 24573D E US24573D E US 24573DE US RE24573 E USRE24573 E US RE24573E
- Authority
- US
- United States
- Prior art keywords
- chlorophyll
- abrasive
- water
- therapeutic
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 title description 29
- 235000019804 chlorophyll Nutrition 0.000 title description 27
- 229930002875 chlorophylls Natural products 0.000 title description 27
- 238000005296 abrasive Methods 0.000 title description 18
- 239000002253 acid Substances 0.000 title description 10
- 230000003472 neutralizing Effects 0.000 title description 8
- 239000000203 mixture Substances 0.000 description 18
- 230000001225 therapeutic Effects 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 239000000551 dentifrice Substances 0.000 description 16
- 239000000606 toothpaste Substances 0.000 description 16
- 229940034610 Toothpaste Drugs 0.000 description 15
- 150000003839 salts Chemical class 0.000 description 12
- 239000011780 sodium chloride Substances 0.000 description 12
- UVOXKYYHMDAWNK-UHFFFAOYSA-L magnesium;3-[20-(carboxylatomethyl)-18-(dioxidomethylidene)-8-ethenyl-13-ethyl-3,7,12,17-tetramethyl-2,3-dihydroporphyrin-23-id-2-yl]propanoate;hydron Chemical class [H+].[H+].[H+].[Mg+2].C1=C([N-]2)C(CC)=C(C)C2=CC(C(=C2C)C=C)=NC2=CC(C(C2CCC([O-])=O)C)=NC2=C(CC([O-])=O)C2=NC1=C(C)C2=C([O-])[O-] UVOXKYYHMDAWNK-UHFFFAOYSA-L 0.000 description 11
- 239000004615 ingredient Substances 0.000 description 8
- 229940099898 chlorophyllin Drugs 0.000 description 7
- 235000019805 chlorophyllin Nutrition 0.000 description 7
- -1 potassium copper Chemical compound 0.000 description 7
- 239000003599 detergent Substances 0.000 description 6
- 239000006072 paste Substances 0.000 description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 5
- 208000007565 Gingivitis Diseases 0.000 description 4
- 210000000214 Mouth Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 229940079841 SODIUM COPPER CHLOROPHYLLIN Drugs 0.000 description 3
- AQMNWCRSESPIJM-UHFFFAOYSA-M Sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 3
- KYLOFEQLMQEHBO-JOKPRTCASA-I copper;trisodium;(8Z,17S,18S)-18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,13,17-trimethyl-8-(oxidomethylidene)-17,18-dihydroporphyrin-21-ide-2-carboxylate Chemical compound [Na+].[Na+].[Na+].[Cu+2].C1=C([N-]2)C(C)=C(C([O-])=O)C2=C(CC([O-])=O)C([C@H]([C@@H]2C)CCC([O-])=O)=NC2=CC(C(=C2C=C)C)=NC2=CC\2=NC1=C(CC)C/2=C\[O-] KYLOFEQLMQEHBO-JOKPRTCASA-I 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 229920000591 gum Polymers 0.000 description 3
- 150000007522 mineralic acids Chemical class 0.000 description 3
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 235000013758 sodium copper chlorophyllin Nutrition 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 241000416162 Astragalus gummifer Species 0.000 description 2
- 229960003563 Calcium Carbonate Drugs 0.000 description 2
- 206010018987 Haemorrhage Diseases 0.000 description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L Magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 2
- 210000003097 Mucus Anatomy 0.000 description 2
- 229920001615 Tragacanth Polymers 0.000 description 2
- 230000000740 bleeding Effects 0.000 description 2
- 231100000319 bleeding Toxicity 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 201000009910 diseases by infectious agent Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000001095 magnesium carbonate Substances 0.000 description 2
- 239000011776 magnesium carbonate Substances 0.000 description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 241000554155 Andes Species 0.000 description 1
- 229940064004 Antiseptic throat preparations Drugs 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000002925 Dental Caries Diseases 0.000 description 1
- 102000014961 Protein Precursors Human genes 0.000 description 1
- 108010078762 Protein Precursors Proteins 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N Saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 210000003296 Saliva Anatomy 0.000 description 1
- 210000000515 Tooth Anatomy 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 230000001458 anti-acid Effects 0.000 description 1
- 230000002421 anti-septic Effects 0.000 description 1
- 230000001488 breeding Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000037123 dental health Effects 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 230000001877 deodorizing Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 235000019645 odor Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- OZAIFHULBGXAKX-UHFFFAOYSA-N precursor Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissues Anatomy 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/58—Metal complex; Coordination compounds
Definitions
- This invention relates to a therapeutic dentifrice; and more particularly to a therapeutic dentifrice containing water soluble chlorophyll, an abrasive constituent, a suitable detergent and an acid neutralizing substance which may either be the abrasive or may be in addition 'to the abrasive.
- a common dental ailment is gingivitis in its various forms, commonly indicated by red, swollen and bleeding gums. It has been estimated that from 80 to 95% of the population have this disease at one time or another.
- the present invention provides a therapeutic toothpaste which is particularly advantageous in the treatment of gingivitis, while also having general utility as a toothpaste.
- the therapeutic toothpaste of the present invention includes water-soluble chlorophyll in amounts ranging from 0.02% to 3%.
- the water-soluble chlorophyll is combined with other ingredients in the toothpaste, including an elfective detergent and an abrasive, and the paste includes antacid or acid-neutralizing ingredients, which may be the abrasive or which may be in. addition to the abrasive, and which maintain the paste at a relatively high pH.
- the usual hygroscopic materials such as glycerin and thickening materials such as a gum and flavoring material may also be advantageously used.
- the detergent used in the dentifrice may be-soap or a detergent such as the salts of the sulfonated alcohols
- the abrasive is advantageously an alkaline or acid neucarbonate, [insoluble sodium meta-phosphate,] or other acid neutralizing abrasives.
- Hygroscopic materials such as glycerin and a thickening agent such as a gum are also
- the water-soluble chlorophyll used'is advantageously a chlorophyllin salt such as sodium or potassium magnesiu'm chlorophyllin, sodium or potassium copper chlorophyllin, sodium or potassium iron chlorophyllin, or combinations of the sodium and potassium salts.
- chlorophyllin salts are water-soluble derivatives of chlorophyll a (C H O N Mg). These chlorophyllin salts are soluble in water but are precipitated from their solutions by acid if the pH falls sufficiently low, e. g., below about pH 5. These water-soluble chlorophyll compounds are used in the dentifrice which is adjusted to maintain a sufliciently high pH, above that at which the chlorophyll is precipitated.
- the chlorophyllin salt e. g. sodium magnesium chlorophyllin or sodium copper chlorophyllin
- the chlorophyllin salt is advantageously used in a relatively high state of purity, e. g. having a been found to have important advantages.
- the relative proportions of the various ingredients of the dentifrice may vary considerably, so long as a substantial amount of water-soluble chlorophyll is present.
- amounts of chlorophyll as small as 0.02% have been found sufficient to contribute therapeutic and cellstimulating properties.
- the amount of water-soluble chlorophyll included in the dentifrice is of the order of 0.1% or 0.2% based on the total weight of the toothpaste.
- improved results are obtained where the quantity of chlorophyll is increased to an amount of the order of 3%.
- the use of large amounts does not greatly increase the therapeutic effect as compared with quantities of the order of from about 0.2% to about 3%, based on the weight of the oral preparation.
- the therapeutic toothpaste of the present invention has It is particularly effective as a mouth deodorant, effectively deodorizing the oral cavity.
- the new therapeutic tooth paste is also particularly eifective in the treatment of gingival conditions, such as tenderness, bleeding and engorgement of gum tissues, and effectively clears up the odors arising from gingivalconditions.
- gingival conditions such as tenderness, bleeding and engorgement of gum tissues
- odors arising from gingivalconditions are the precursors of pyorrhea, to which a far greater loss of v teeth is attributed than to tooth decay.
- dental surgery may be required; but the new toothpaste is a valuable adjunct to such dental surgery.
- the continual flow of saliva deposits a coating of mucus which prevents therapeutic agents from reaching the areas in which its effects are required. It is necessary to reach and exert an effect on all the spaces which lie beneath the mucus coating to accomplish a therapeutic result.
- the new therapeutic toothpaste is eifective in removing such coatings and in accomplishing the desired therapeutic result.
- the new therapeutic toothpaste is efiectivein that it is carried by the brush to all sections of the gingivae and to cracks or crevices and localized areas, interproximal' spaces and pockets, subjecting such areas to the combined action of the chlorophyll, detergent, abrasive, and acid conditions.
- composition as defined in claim in which the inorganic salt is magnesium carbonate.
- EXAMPLE II Another paste dentifrice was made exactly as described in Example I, except that in place of the five tenths of a gram of gum tragacanth,'five tenths of a gram of pectin was used.
- EXAMPLE III Another paste dentifrice was made as described in Example -I, except that in place of the sodium magnesium chlorophyllin 0.1 to 0.2% of sodium copper chlorophyllin was used.
- An acid-stabilized dentifrice composition substantially free of water-insoluble precipitated chlorophyll both in storage and'in use, therapeutically effective in the treatment of gingival conditions containing as essential ingredients an inorganic acid neutralizing salt of relatively low solubility 'in water and 0.02 to 3% by weight of a water solublechlorophyll, said salt being in an amount sufficient to impart an abrasive action to said composition and at the same time tornaintain the pH of said composition sufficiently high to maintain said water soluble chlorophyll in its water soluble and therapeutically effective form.
- composition as defined in claim 1 in which the inorganic [acid] salt is selected from the group consisting of calcium carbonate [,1 and magnesium carbonate' [and insoluble sodium metaphosph-ate].'
- a composition as defined in claim 5 in which the inorganic salt is insoluble sodium metaphosphate 9.
- An acid-stabilized dentifrice composition substantially free of water-insoluble precipitated chlorophyll both in storageand in use, therapeutically effective in the treatment of gingival conditions containing as essential ingredients an inorganic acid neutralizing abrasive salt of relatively low solubility in water and 0.02 to 3% by weight of a water soluble chlorophyll, said salt being in an amount sufficient to impart an abrasive action to said composition and at the same time to maintain the pH of said composition sufficiently high to maintain said water soluble chlorophyll in its water soluble and therapeutically effective form, the abrasive salt being coated with or having an absorbed layer of the water soluble chlorophyll.
- An acid-stabilized dentifrice composition substantially free of water-insoluble precipitated chlorophyll both instorage and in use, therapeutically effective.
- an inorganic acid neutralizing abrasive salt of relatively low solubility in water and from about 0.1% to 0.2% by weightof a water soluble chlorophyll said salt being in an amount sufficient to impart an abrasive action to said composition and at the same time to maintain the pH of said composition sufiiciently high to .maintain said water soluble chlorophyll in its water soluble and therapeutically effective form, the abrasive salt being. coated with or having an absorbed layer of the .water soluble chlorophyll.
- Bennett The Cosmetic Formulary, N. Y., 1937, p. 211.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Description
advantageously used.
United States Patent Ofi Re.24,573 Reissued Dec. 9, 1958 ice ACID NEUTRALIZIN G ABRASIVE CHLOROPHYLL DEN TIF RICE Benjamin Gruskin, Atlantic City, N. J., deceased, by Rystan Company, Mount Vernon, N. Y., assignee No Drawing. Original No. 2,773,802, dated Decemb r 11, 1956, Serial No. 214,628, March 8, 1951. Application for reissue August 29, 1957, Serial No. 682,561
9 Claims. (Cl. 167-93) Matter enclosed in heavy brackets [II appears in the original patent but forms no part of this reissue specification; matter printed in italics indicates the additions made by reissue.
This invention relates to a therapeutic dentifrice; and more particularly to a therapeutic dentifrice containing water soluble chlorophyll, an abrasive constituent, a suitable detergent and an acid neutralizing substance which may either be the abrasive or may be in addition 'to the abrasive.
A common dental ailment is gingivitis in its various forms, commonly indicated by red, swollen and bleeding gums. It has been estimated that from 80 to 95% of the population have this disease at one time or another.
The present invention provides a therapeutic toothpaste which is particularly advantageous in the treatment of gingivitis, while also having general utility as a toothpaste.
The therapeutic toothpaste of the present invention includes water-soluble chlorophyll in amounts ranging from 0.02% to 3%. The water-soluble chlorophyll is combined with other ingredients in the toothpaste, including an elfective detergent and an abrasive, and the paste includes antacid or acid-neutralizing ingredients, which may be the abrasive or which may be in. addition to the abrasive, and which maintain the paste at a relatively high pH. The usual hygroscopic materials such as glycerin and thickening materials such as a gum and flavoring material may also be advantageously used.
The'presence of an effective detergent and abrasive is important, and the presence of an effective acid neutralizing ingredient is also important, making the resulting chlorophyll-containing dentifrice a particularly effective therapeutic dentifrice.
The detergent used in the dentifrice may be-soap or a detergent such as the salts of the sulfonated alcohols The abrasive is advantageously an alkaline or acid neucarbonate, [insoluble sodium meta-phosphate,] or other acid neutralizing abrasives. Hygroscopic materials such as glycerin and a thickening agent such as a gum are also The water-soluble chlorophyll used'is advantageously a chlorophyllin salt such as sodium or potassium magnesiu'm chlorophyllin, sodium or potassium copper chlorophyllin, sodium or potassium iron chlorophyllin, or combinations of the sodium and potassium salts. These chlorophyllin salts are water-soluble derivatives of chlorophyll a (C H O N Mg). These chlorophyllin salts are soluble in water but are precipitated from their solutions by acid if the pH falls sufficiently low, e. g., below about pH 5. These water-soluble chlorophyll compounds are used in the dentifrice which is adjusted to maintain a sufliciently high pH, above that at which the chlorophyll is precipitated.
The chlorophyllin salt, e. g. sodium magnesium chlorophyllin or sodium copper chlorophyllin, is advantageously used in a relatively high state of purity, e. g. having a been found to have important advantages.
purity around to or greater. If relatively less containing 15% water soluble chlorophyllin salt, a correspondingly greater amount will be required to supply suificient water-soluble chlorophyll to the dentrifrice.
The relative proportions of the various ingredients of the dentifrice may vary considerably, so long as a substantial amount of water-soluble chlorophyll is present. Thus, amounts of chlorophyll as small as 0.02% have been found sufficient to contribute therapeutic and cellstimulating properties. Advantageously, however, the amount of water-soluble chlorophyll included in the dentifrice is of the order of 0.1% or 0.2% based on the total weight of the toothpaste. In some cases, improved results are obtained where the quantity of chlorophyll is increased to an amount of the order of 3%. On the other hand, the use of large amounts does not greatly increase the therapeutic effect as compared with quantities of the order of from about 0.2% to about 3%, based on the weight of the oral preparation. The therapeutic toothpaste of the present invention has It is particularly effective as a mouth deodorant, effectively deodorizing the oral cavity.
The new therapeutic tooth paste is also particularly eifective in the treatment of gingival conditions, such as tenderness, bleeding and engorgement of gum tissues, and effectively clears up the odors arising from gingivalconditions. These gingival conditions, if uncontrolled, are the precursors of pyorrhea, to which a far greater loss of v teeth is attributed than to tooth decay. In serious cases of gingivitis, dental surgery may be required; but the new toothpaste is a valuable adjunct to such dental surgery.
In many cases of gingivitis, use of the new toothpaste and acid neutralizing ingredients, accomplishes over-all I therapeutic effects in the oral cavity in a particularly effective manner. Thus, there are numerous small pockets and interproximal spaces which harbor debris and bacteria and provide localized sources for the breeding of infection which must be cleared up if overall dental health is to be accomplished. The new toothpaste is effective in the treatment of such pockets and spaces and in clearing up the sources of such infection.
Likewise, in the oral cavity, the continual flow of saliva deposits a coating of mucus which prevents therapeutic agents from reaching the areas in which its effects are required. It is necessary to reach and exert an effect on all the spaces which lie beneath the mucus coating to accomplish a therapeutic result. The new therapeutic toothpaste is eifective in removing such coatings and in accomplishing the desired therapeutic result.
The new therapeutic toothpaste is efiectivein that it is carried by the brush to all sections of the gingivae and to cracks or crevices and localized areas, interproximal' spaces and pockets, subjecting such areas to the combined action of the chlorophyll, detergent, abrasive, and acid conditions.
7. A composition as defined in claim in which the inorganic saltis magnesium carbonate.
The invention will be further illustrated by the following examples, but it will be understood thatthe'invention is not limited thereto.
EXAMPLE I Five tenths of a gram of gum tragacanth and five grams.
of castile soap powder were carefully ground together into 20 cc. of distilled water. A quantity of a finely ground chlorophyll composition containing 2 grams of sodium magnesium chlorophyllin was then carefully mixed in. Finally 20 cc. of glycerin, 5 3 grams of precipitated chalk and 1.5 grams of flavoring oils (oil of wintergreen and saccharine totaste) were added and evenly distributed in the mixture to provide a uniform composition. This composition is a paste dentifrice adapted to be applied in the usual manner of using paste dentifrices.
EXAMPLE II Another paste dentifrice was made exactly as described in Example I, except that in place of the five tenths of a gram of gum tragacanth,'five tenths of a gram of pectin was used.
EXAMPLE III Another paste dentifrice was made as described in Example -I, except that in place of the sodium magnesium chlorophyllin 0.1 to 0.2% of sodium copper chlorophyllin was used.
This application is a continuation-in-part of application Serial No. 466,299, filed November 20, 1942, which application was a continuation-in-part of application Serial No.- 367,676,filed November 28, 1940, both now abandoned.
What is claimed is:
' 1. An acid-stabilized dentifrice composition, substantially free of water-insoluble precipitated chlorophyll both in storage and'in use, therapeutically effective in the treatment of gingival conditions containing as essential ingredients an inorganic acid neutralizing salt of relatively low solubility 'in water and 0.02 to 3% by weight of a water solublechlorophyll, said salt being in an amount sufficient to impart an abrasive action to said composition and at the same time tornaintain the pH of said composition sufficiently high to maintain said water soluble chlorophyll in its water soluble and therapeutically effective form.
2. A therapeutic toothpaste as defined in claim 1, containing about 0.1 to 0.2% of a soluble alkali metal chlorophyllin salt.
3. A therapeutic toothpaste as defined in claim 1, containing about 0.1 to 0.2% of sodium magnesium chlorophyllin.
4. A therapeutic toothpaste as defined in claim 1, containing about 0.1 to 0.2% sodium copper chlorophyllin.
5. A composition as defined in claim 1 in which the inorganic [acid] salt is selected from the group consisting of calcium carbonate [,1 and magnesium carbonate' [and insoluble sodium metaphosph-ate].'
6. A composition as defined in claim 5 in which the I inorganic salt is calcium carbonate.
[8. A composition as defined in claim 5 in which the inorganic salt is insoluble sodium metaphosphate] 9. An acid-stabilized dentifrice composition, substantially free of water-insoluble precipitated chlorophyll both in storageand in use, therapeutically effective in the treatment of gingival conditions containing as essential ingredients an inorganic acid neutralizing abrasive salt of relatively low solubility in water and 0.02 to 3% by weight of a water soluble chlorophyll, said salt being in an amount sufficient to impart an abrasive action to said composition and at the same time to maintain the pH of said composition sufficiently high to maintain said water soluble chlorophyll in its water soluble and therapeutically effective form, the abrasive salt being coated with or having an absorbed layer of the water soluble chlorophyll.
10. An acid-stabilized dentifrice composition, substantially free of water-insoluble precipitated chlorophyll both instorage and in use, therapeutically effective. in the treatment of gingival conditions containing as essential ingredients an inorganic acid neutralizing abrasive salt of relatively low solubility in water and from about 0.1% to 0.2% by weightof a water soluble chlorophyll, said salt being in an amount sufficient to impart an abrasive action to said composition and at the same time to maintain the pH of said composition sufiiciently high to .maintain said water soluble chlorophyll in its water soluble and therapeutically effective form, the abrasive salt being. coated with or having an absorbed layer of the .water soluble chlorophyll.
References Cited in the file of this patent Welwart: Antiseptics for Tooth Pastes, The Mfg. Chemist, February 1933, pp. and 48.
Bennett: The Cosmetic Formulary, N. Y., 1937, p. 211.
Amer. Jour. of Surgery, July 1940, pp. 54, (Gruskin: Chlorophyll).
Amer. Perf. andEss. Oil Review, October 1949, p. 281.
The N. Y. J our. of Dentristry, January 1950, pp. 3 to 5.
The Military Surgeon, May 1950, pp. 352-354.
Iour. Amer. Dent. Assn, vol, 40, May, 1950, p. 625' Consumer Rpts, October ,1950, Chlorophyll, the Latest Drug Fadif p. 458. I v a
Publications (1)
| Publication Number | Publication Date |
|---|---|
| USRE24573E true USRE24573E (en) | 1958-12-09 |
Family
ID=2092784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US24573D Expired USRE24573E (en) | Acid neutralizing abrasive chlorophyll |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | USRE24573E (en) |
-
0
- US US24573D patent/USRE24573E/en not_active Expired
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