USRE23404E - Reaction of organic compounds with - Google Patents
Reaction of organic compounds with Download PDFInfo
- Publication number
- USRE23404E USRE23404E US23404DE USRE23404E US RE23404 E USRE23404 E US RE23404E US 23404D E US23404D E US 23404DE US RE23404 E USRE23404 E US RE23404E
- Authority
- US
- United States
- Prior art keywords
- sulphur dioxide
- hydrogen
- liquid
- solution
- liquid sulphur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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- 150000002894 organic compounds Chemical class 0.000 title description 26
- 238000006243 chemical reaction Methods 0.000 title description 16
- RAHZWNYVWXNFOC-UHFFFAOYSA-N sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 148
- 239000004291 sulphur dioxide Substances 0.000 description 74
- 235000010269 sulphur dioxide Nutrition 0.000 description 74
- CPELXLSAUQHCOX-UHFFFAOYSA-N hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 60
- 239000007788 liquid Substances 0.000 description 49
- PPBRXRYQALVLMV-UHFFFAOYSA-N styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 34
- 229910000039 hydrogen halide Inorganic materials 0.000 description 28
- 239000012433 hydrogen halide Substances 0.000 description 28
- 229910000042 hydrogen bromide Inorganic materials 0.000 description 27
- 238000000034 method Methods 0.000 description 24
- 239000000203 mixture Substances 0.000 description 22
- 239000000047 product Substances 0.000 description 17
- 150000001875 compounds Chemical class 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 239000000376 reactant Substances 0.000 description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 8
- 238000007792 addition Methods 0.000 description 8
- 239000011541 reaction mixture Substances 0.000 description 8
- 239000001117 sulphuric acid Substances 0.000 description 8
- 235000011149 sulphuric acid Nutrition 0.000 description 8
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 7
- WKBOTKDWSSQWDR-UHFFFAOYSA-N bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- VZGDMQKNWNREIO-UHFFFAOYSA-N Carbon tetrachloride Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 6
- -1 HYDROGEN HALIDES Chemical class 0.000 description 6
- 125000001931 aliphatic group Chemical group 0.000 description 6
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 6
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 238000005647 hydrohalogenation reaction Methods 0.000 description 5
- 239000000460 chlorine Substances 0.000 description 4
- 229910052801 chlorine Inorganic materials 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000003208 petroleum Substances 0.000 description 4
- BHELZAPQIKSEDF-UHFFFAOYSA-N Allyl bromide Chemical compound BrCC=C BHELZAPQIKSEDF-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 239000001569 carbon dioxide Substances 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
- 239000005457 ice water Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- 150000002978 peroxides Chemical class 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 2
- CRRUGYDDEMGVDY-UHFFFAOYSA-N 1-bromoethylbenzene Chemical compound CC(Br)C1=CC=CC=C1 CRRUGYDDEMGVDY-UHFFFAOYSA-N 0.000 description 2
- RDHPKYGYEGBMSE-UHFFFAOYSA-N Bromoethane Chemical compound CCBr RDHPKYGYEGBMSE-UHFFFAOYSA-N 0.000 description 2
- KRVSOGSZCMJSLX-UHFFFAOYSA-L Chromic acid Chemical compound O[Cr](O)(=O)=O KRVSOGSZCMJSLX-UHFFFAOYSA-L 0.000 description 2
- NNBZCPXTIHJBJL-UHFFFAOYSA-N Decalin Chemical compound C1CCCC2CCCCC21 NNBZCPXTIHJBJL-UHFFFAOYSA-N 0.000 description 2
- DIOQZVSQGTUSAI-UHFFFAOYSA-N Decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- YBYIRNPNPLQARY-UHFFFAOYSA-N Indene Chemical compound C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 description 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N Linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 2
- LQNUZADURLCDLV-UHFFFAOYSA-N Nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 description 2
- 239000005864 Sulphur Substances 0.000 description 2
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N Tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 2
- HGINCPLSRVDWNT-UHFFFAOYSA-N acrylaldehyde Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 description 2
- 230000000111 anti-oxidant Effects 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N benzohydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 230000002939 deleterious Effects 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 150000004820 halides Chemical class 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 238000005658 halogenation reaction Methods 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 239000012442 inert solvent Substances 0.000 description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- KWOLFJPFCHCOCG-UHFFFAOYSA-N methylphenylketone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 238000007086 side reaction Methods 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- YXFVVABEGXRONW-UHFFFAOYSA-N toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- OZXIZRZFGJZWBF-UHFFFAOYSA-N 1,3,5-trimethyl-2-(2,4,6-trimethylphenoxy)benzene Chemical compound CC1=CC(C)=CC(C)=C1OC1=C(C)C=C(C)C=C1C OZXIZRZFGJZWBF-UHFFFAOYSA-N 0.000 description 1
- WLJXUWKOEVKMGD-UHFFFAOYSA-N 1-chloro-2,3-dihydro-1H-indene Chemical compound C1=CC=C2C(Cl)CCC2=C1 WLJXUWKOEVKMGD-UHFFFAOYSA-N 0.000 description 1
- WAPNOHKVXSQRPX-UHFFFAOYSA-N 1-phenylethanol Chemical compound CC(O)C1=CC=CC=C1 WAPNOHKVXSQRPX-UHFFFAOYSA-N 0.000 description 1
- WMPPDTMATNBGJN-UHFFFAOYSA-N 2-Phenylethylbromide Chemical compound BrCCC1=CC=CC=C1 WMPPDTMATNBGJN-UHFFFAOYSA-N 0.000 description 1
- FNIBRUOFKCBDGB-UHFFFAOYSA-N 2-bromo-2-phenylpropanoic acid Chemical compound OC(=O)C(Br)(C)C1=CC=CC=C1 FNIBRUOFKCBDGB-UHFFFAOYSA-N 0.000 description 1
- LDLCZOVUSADOIV-UHFFFAOYSA-N 2-bromoethanol Chemical compound OCCBr LDLCZOVUSADOIV-UHFFFAOYSA-N 0.000 description 1
- VYWYYJYRVSBHJQ-UHFFFAOYSA-M 3,5-dinitrobenzoate Chemical compound [O-]C(=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1 VYWYYJYRVSBHJQ-UHFFFAOYSA-M 0.000 description 1
- ZSPTYLOMNJNZNG-UHFFFAOYSA-N 3-Buten-1-ol Chemical compound OCCC=C ZSPTYLOMNJNZNG-UHFFFAOYSA-N 0.000 description 1
- CLRSZXHOSMKUIB-UHFFFAOYSA-M Benzenediazonium chloride Chemical compound [Cl-].N#[N+]C1=CC=CC=C1 CLRSZXHOSMKUIB-UHFFFAOYSA-M 0.000 description 1
- KVNRLNFWIYMESJ-UHFFFAOYSA-N Butyronitrile Chemical compound CCCC#N KVNRLNFWIYMESJ-UHFFFAOYSA-N 0.000 description 1
- JGLCJSXGAJFNGS-UHFFFAOYSA-N C(CC)N(Br)Br Chemical compound C(CC)N(Br)Br JGLCJSXGAJFNGS-UHFFFAOYSA-N 0.000 description 1
- YCIMNLLNPGFGHC-UHFFFAOYSA-N Catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 1
- 101700057010 Cont Proteins 0.000 description 1
- NKNDPYCGAZPOFS-UHFFFAOYSA-M Copper(I) bromide Chemical compound Br[Cu] NKNDPYCGAZPOFS-UHFFFAOYSA-M 0.000 description 1
- ZSWFCLXCOIISFI-UHFFFAOYSA-N Cyclopentadiene Chemical compound C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 description 1
- PXBRQCKWGAHEHS-UHFFFAOYSA-N Dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
- 239000004338 Dichlorodifluoromethane Substances 0.000 description 1
- 241000152160 Ira Species 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N Maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- MTZWHHIREPJPTG-UHFFFAOYSA-N Phorone Chemical compound CC(C)=CC(=O)C=C(C)C MTZWHHIREPJPTG-UHFFFAOYSA-N 0.000 description 1
- TVDSBUOJIPERQY-UHFFFAOYSA-N Propargyl alcohol Chemical compound OCC#C TVDSBUOJIPERQY-UHFFFAOYSA-N 0.000 description 1
- 229940075582 Sorbic Acid Drugs 0.000 description 1
- 229940035295 Ting Drugs 0.000 description 1
- WFYPICNXBKQZGB-UHFFFAOYSA-N Vinylacetylene Chemical group C=CC#C WFYPICNXBKQZGB-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000001350 alkyl halides Chemical class 0.000 description 1
- 230000003078 antioxidant Effects 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 150000001502 aryl halides Chemical class 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 125000006267 biphenyl group Chemical group 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 229930004021 citronellol Natural products 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 231100000078 corrosive Toxicity 0.000 description 1
- 231100001010 corrosive Toxicity 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 229940042935 dichlorodifluoromethane Drugs 0.000 description 1
- 235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001640 fractional crystallisation Methods 0.000 description 1
- 238000004508 fractional distillation Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011491 glass wool Substances 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- PYGSKMBEVAICCR-UHFFFAOYSA-N hexa-1,5-diene Chemical group C=CCCC=C PYGSKMBEVAICCR-UHFFFAOYSA-N 0.000 description 1
- 239000008079 hexane Substances 0.000 description 1
- 125000001145 hydrido group Chemical group *[H] 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006011 modification reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N oxane Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 150000007659 semicarbazones Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- WSWCOQWTEOXDQX-UHFFFAOYSA-N sorbic acid Chemical compound CC=CC=CC(O)=O WSWCOQWTEOXDQX-UHFFFAOYSA-N 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000001119 stannous chloride Substances 0.000 description 1
- 229940013123 stannous chloride Drugs 0.000 description 1
- 235000011150 stannous chloride Nutrition 0.000 description 1
- 150000003440 styrenes Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 125000001174 sulfone group Chemical group 0.000 description 1
- 101700082413 tant Proteins 0.000 description 1
- FWPIDFUJEMBDLS-UHFFFAOYSA-L tin dichloride dihydrate Chemical compound O.O.Cl[Sn]Cl FWPIDFUJEMBDLS-UHFFFAOYSA-L 0.000 description 1
- YIYBQIKDCADOSF-ONEGZZNKSA-N trans-pent-2-enoic acid Chemical compound CC\C=C\C(O)=O YIYBQIKDCADOSF-ONEGZZNKSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 150000003738 xylenes Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/07—Preparation of halogenated hydrocarbons by addition of hydrogen halides
- C07C17/08—Preparation of halogenated hydrocarbons by addition of hydrogen halides to unsaturated hydrocarbons
Definitions
- the present invention relates to a novel process [for preparing halogenated organic compounds and, more particularly, to a new method of hydrohalogenating unsaturated organic bodies] of hydrohalogenating styrene and the like.
- anhydrous hydrogen halide is contacted for a relatively short time with the styrene [an unsaturated organic compound; to be hydrohalogenated.
- Contact is advantageously effectuated in an inert, non-aqueous, polar medium, such as liquid sulphur dioxide, and the hydrogen halide, say hydrogen chloride or hydrogen bromide, is preferably formed in situ in the medium before contact with the organic compound.
- the hydrogen halide say hydrogen chloride or hydrogen bromide
- the hydrogen halide e. g., hydrogen bromide
- the hydrogen halide is preferably employed in substantially anhydrous condition.
- This method comprises contacting a halogen (e. g., bromine) dissolved in liquid sulphur dioxide with water to produce the hydrogen halide (e. g., hydrogen bromide) and sulphuric acid.
- a halogen e. g., bromine
- the hydrogen halide e. g., hydrogen bromide
- sulphuric acid e.g., a considerable excess of sulphur dioxide is advantageously used, the liquid sulphur dioxide preferably serving as a solvent for the bromine and for the hydrogen bromide formed.
- Chlorine may be similarly reacted to form anhydrous hydrogen chloride.
- the process of the invention is applicable for hydrohalogenation, and especially for hydrobromination, of organic unsaturated compounds, particularly those of the olenfinic and acetylenic types. These include unsaturated aliphatic hydrocarbons, acids, alcohols, aldehydes, others, ketones and the like, as well as derivatives of these compounds, including sulphonated, nitrated, halogenated, 0r aryl-substituted bodies, etc., and the like.
- Compounds satisfactory for hydrohalogenation by the present process include propylene, decene-l, 5-chlorpentene-2, crotcnylene, isoprene, diallyl (hexadiene-l,5) allyl bromide, heptyne-l, styrene, vinyl acetylene, dehydro-undecylenic acid, beta-ethyl-acrylic acid, sorbic acid, linoleic acid, maleic anhydride, sinnamic acid, cyclopentadiene, allyl carbinol, citronellol, l-nitroisobutylene-Z, acrolein, propargylic aldehyde, crotyl ethyl ether, vinyl prODYl ketone, mesityl oxide, phorone, indene, etc.
- the organic compound if solid, may be added directly to the liquid sulphur dioxide solution and may be dissolved or suspended therein, or it may be liquefied prior to admixture by the use of heat and/or of solvents]
- the mixture may also b made by running the sulphur dioxide solution of hydrogen halide into the styrene [organic compound] to be hydrohalogenated or the two bodies may be passed in countercurrent to eachother in continuous operation].
- the or anic reactants may advantageously be dissolved in-another inert solvent for admixture the hydrogen halide especially where the reactant is insoluble or only slightly soluble in liquid sulphur dioxide].
- the reaction mixture may thus be of either one or two liquid phases, and it is preferred that the solvent selected be at least partly miscible with liquid sulphur dioxide.
- Suitablesolvents or suspending media for the unsaturated organic reac'tant include [butane, pentane, hexane, decane and other alkanes; carbon tetrachloride, chloroform, ethylene dichloride, ethyl bromide, dichloro-difluoromethane, and other halogenated hydrocarbons; cyclohexane; decalin, tetralin and other cycloaliphatics; benzene, toluene, the xylenes, naphthalene, diphenyl, nitrobenzene and other aromatic hydrocarbons together with their n-itro-, halogeno-, and other derivatives; petroleum etherand gasoline; liquid-carbon dioxide; liquidsulphur dioxide;] ethyl ether, dioxaneand other ethers; [carbon disulphidefl and the like,
- the contact of the styrene [organic reactant] with the liquid sulphur dioxide solution of the hydrogen halide is preferably aided by agitation, especially where more than one phase is present.
- the time of contact varies appreciably, [depend ing upon the compound to be hydrohalogenated,] but it has-been observed that high yields are obtainable with most reactants after about fifteen to about thirty minutes, and in some cases in even shorter time.
- the proportions of the styreneIorganic reactant] to the hydrogen halide may vary widely, [especially for different degrees of hydrohalogenation where poly-unsaturated or acetylenic groups are reacted].
- reaction temperatures and pressures may also be varied within wide limits again depending upon the compound to be reacted and the product to be formed]. In general, it is preferred to carry out the reaction at temperatures around -10 C.
- the sulphur dioxide is removed from the reaction mixture. This may be accomplished by bubbling an inert gas, such as carbon dioxide, nitrogen, stack gases, etc., through the mixture, and/or by gradually pouring the mixture into ice water or'upon ice, during which operation mostof the liquidsulphur dioxide volatilizes, and/or by other means.
- Suitable equipment may be provided for carrying out these operations, whereby the volatility of the sulphur dioxide may be increased, as by reducing the pressure'in the system.
- Such equipment may also be provided with condensers, whereby'the volatilized sulphur dioxide and/or other solvent employed may be recovered for reuse.
- the nature of the product formed is such that its temperature may be increased. without deleterious effect, so that most or all of the remaining solvent may be removed from the reaction mixture by heating or the like.
- Known methods including fractional distillation, fractional crystallization, extraction, and other separation procedures or any combination of these, may be employed for separating the product from the aqueous mass and/or from unreacted materials.
- Example [I] About 250 cc. of liquid sulphur dioxide is tapped from an inverted cylinder of sulphur dioxide into a cylindrical, unsilveredDewar flask of about 1 liter capacity, open at the top, and provided with an electric stirrer and with a stop cock at its lower end. About grams of bromine are added to the liquid sulphur dioxide and are dissolved therein, the sulphur dioxide vapors acting as a blanket to keep atmospheric oxygen and moisture out of the vessel. About 16 grams of water are then slowly added with stirring until the reddish brown color of the bromine is discharged. A lower layer of sulphuric acid collects at the bottom of the Dewar flask upon standing and is permitted to remain there.
- the petroleum ether is then evaporated to yield about 39.4 grams of alpha-bromoethylene as a colorless, harsh-smelling liquid.
- the produce obtained distills at about 64 C. to about 66 C. at a pressure of 8 mm. of mercury, and the amount obtained is equivalent to about 86.5% of the calculated theoretical yield.
- the structure of the product is confirmed by reacting a portion thereof with sodium acetate in acetic acid to form an acetate which, after saponification, yields an alcohol boiling at about 201 C.
- the alcohol by conversion to the 3,5- dinitrobenzoate melting at about 92 C. to 95 C., is proven to be alpha-phenylethyl alcohol.
- a portion of this alcohol is oxidized with chromic acid to obtain acetophenone, recognized by the semicarbazone melting at about 196 C. It thus appears that hydrogen bromide can be added to styrene, in accordance with the procedure of the present invention, and follows the Markownikofi rule to give alpha-bromoethylbenzene.
- Example II to evaporate sulphur dioxide, and the product is extracted with petroleum ether, dried and distilled.
- the product comprises bromophenylpropionic acid.
- Example III [To a solution of about grams of hydrogen bromide in about 250 cc. of sulphur dioxide at for about thirty minutes.
- Example V [About 20 grams of chlorine are dissolved in about 250 cc. of liquid sulphur dioxide, and water is slowly added to form hydrogen chloride in situ.
- Example VI [About 23 grams of freshly distilled propargyl alcohol are slowly added to an anhydrous solution of about 40 grams of hydrogen bromide in about 250 cc. of liquid sulphur dioxide. The mixture is stirred for about fifteen minutes, and the mixture is then poured into ice water.
- Example VII Anhydrous solution of about 90 parts by weight of hydrogen bromide per hour dissolved in about 600 parts of liquid sulphur dioxide per hour are run slowly downward through a column. At a point above the lowest portion of the column, about 30 parts of ethylene per hour are passed into the column and are bubbled through the downwardly flowing solution. The reaction product is removed at the bottom of the column together with liquid sulphur dioxide, from which it is separated and recovered. The unreacted ethylene and volatilized sulphur dioxide are withdrawn at the top of the column.
- the product comprises ethyl bromide] [Example VIII] [About 42 grams of freshly distilled ethylene oxide are mixed into an anhydrous solution of about 80 grams of hydrogen bromide in liquid sulphur dioxide. Following the procedure as set forth in Example I, ethylene bromohydrin is obtained as a product] stituted acids.
- Example IX [About 50 grams of freshly distilled propyl cyanide are slowly added with stirring to an anhydrous solution of about .80 grams of hydrogen bromide in liquid sulphur dioxide. The procedure of Example I is followed, and a product comprised propyl imino-bromide is obtained]
- the use of anhydrous hydrogen halide for these reactions is of considerable advantage in obtaining high yields and high quality of product.
- Liquid sulphur dioxide has many advantages as a solvent for the reactants, being inexpensive, easily removable, non-corrosive and noninfiammable and having a, low boiling-point. Close controlv of reaction temperatures, ordinarily unattainable or attainable only with great difliculty, can be easily maintained in liquid sulphur dioxide, especially with regulation of pressure.
- hydrogen bromide in liquid sulphur dioxide may be employed in double decomposition and substitution reactions.
- Alkyl halides may be formed by contacting alcohols with a hydrogen halide in liquid sulphur dioxide.
- hydroxyl substituted aliphatic acids may be added to solutions of a hydrogen halide in sulphur dioxide to form the correspondin halogen-sub- Hydrogen bromide in liquid sulphur dioxide can also be used as an esterification catalyst for influencing the reaction of an organic carboxylic acid with an alcohol to form an ester.
- aryl halides can be formed by reaction of a hydrogen halide in liquid sulphur dioxide with aryl diazonium halides in the presence of a suitable catalyst; thus, benzene diazonium chloride, when mixed with hydrogen bromide inthe presence of liquid sulphur dioxide and cuprous bromide as 'a, catalyst, gives a product comprising brombenzene]
- the process of reacting unsaturated organic compounds with hydrogen bromide which comprises mixing a solution of anhydrous hydrogen bromide in liquid sulphur dioxide with an unsaturated organic compound capable of adding the inven- '8 hydrogen bromide, "and removing sulphur "dioxide from said mixture] [4.
- the process of reacting organic compounds with hydrogen bromide which comprises preparing a solution of anhydrous hydrogen bromide in liquid sulphur dioxide, -intimately contacting said solution with an organic compound having an unsaturated aliphatic group capable .of ad'ding hydrogen bromide, and removing sulphur dioxide from said mixture] [5.
- the improvement which'comprises intimately contacting said compound with anhydrous hydrogen bromide while at least one of said reactants is dissolved 'in'liquid sulphurdioxide] [6.
- the improvement which comprises preparing a solution of anhydrous hydrogen bromide in liquid sulphur dioxide, mixing said solution with said organic compound, removin sulphur dioxide from said mixture to leave a residue,,and recovering the addition product from said residue] [9.
- the improvement which comprises ,preparing a solution of anhydrous hydrogen chloride in liquid sulphur dioxide, mixing said solution withsaid organic compound, removing sulphur dioxide from said mixture to leave a residue, and recovering the addition product from said residue] [10.
- the improvement which comprises preparing a solution of anhydrous hydrogen bromide in liquid sulphur dioxide, dissolving said organic compound in-a substantially inert solvent at least partially miscible with liquid sulphur dioxide to form a second solution, intimatelymixing said solutions, removing sulphur dioxide from said mixture to leave a residue, and recovering the addition product from said residue] .11.
Description
Reiasued Sept. 4, 1951 REACTION OF ORGANIC COMPOUNDS WITH HYDROGEN HALIDES ArthurIra Gebhart, Union, N. J assignor to C01- gate-Palmolive-Peet Company, Jersey City, N. J a corporation of Delaware No Drawing. Original No. 2,459,423, dated J anuary 18, 1949, Serial No. 510,219, November 13.
1950, Serial No. 202,582
2 Claims.
Application for reissue December 23,
Matter enclosed in heavy brackets appears in the original patent but forms no part of this reissue specification; matter printed in italics indicates the additions made The present invention relates to a novel process [for preparing halogenated organic compounds and, more particularly, to a new method of hydrohalogenating unsaturated organic bodies] of hydrohalogenating styrene and the like.
Hydrohalogenation of organic compounds has always presented considerable difliculties to .prior art investigators, and hydrobromination has been especially troublesome, both in the preparation of the hydrogen bromide and in its addition to unsaturated bonds. Thus, a common method of preparing hydrogen bromide has been to drop bromine upon a mixture of red phosphorus, water and sand and to pass the resulting vapors over moist red phosphorus spread over glass wool in a 1 U-tube, a procedure which is both long and troublesome. The hydrogen bromide is then added directly or in solution in an organic solvent to an unsaturated compound, and the mixture frequently takes several hours in order to form the addition product. This addition rocedure, besides being a tedious one, is generally unproductive either of good yields or of good quality of the product.
It is an object of the present invention to provide a new method for rapidly preparing good yields of halogenated styrene [organic compounds] of high purity.
It is also an object of this invention to provide a novel process for adding anhydrous hydrogen halide, particularly anhydrous hydrogen bromide, to styrene [unsaturated organic aliphatic groups].
Other objects and advantages of the invention will be apparent from the following description.
According to the present invention, anhydrous hydrogen halide is contacted for a relatively short time with the styrene [an unsaturated organic compound; to be hydrohalogenated. Contact is advantageously effectuated in an inert, non-aqueous, polar medium, such as liquid sulphur dioxide, and the hydrogen halide, say hydrogen chloride or hydrogen bromide, is preferably formed in situ in the medium before contact with the organic compound. After hydrohalogenatio-n, the liquid sulphur dioxide is removed, and the halogenated product is recovered.
The hydrogen halide (e. g., hydrogen bromide) is preferably employed in substantially anhydrous condition. A suitable method for preparby reissue.
ing substantially anhydrous hydrogen halide has been described in the application (Serial No.
438,075 new Patent No. 2,339,330, issued January 18, 1944) of which the present case is a division. This method comprises contacting a halogen (e. g., bromine) dissolved in liquid sulphur dioxide with water to produce the hydrogen halide (e. g., hydrogen bromide) and sulphuric acid. In practice, a considerable excess of sulphur dioxide is advantageously used, the liquid sulphur dioxide preferably serving as a solvent for the bromine and for the hydrogen bromide formed. Chlorine may be similarly reacted to form anhydrous hydrogen chloride. It is preferred, especially when preparing hydrogen chloride by this method, that an amount of water be added at least sufficient to react with all free halogen present, as the presence of free chlorine in subsequent halogenations may give undesired side reactions. Sulphuric acid of concentration up to has low solubility in liquid sulphur dioxide at 0C. and lower and forms a separate lower layer which is advantageous [may be withdrawn, if desired, although the presence of sulphuric acid in the subsequent halogenation is frequently not disadvantageous. Indeed, in certain reactions, such as the esterificatio-n of an alcohol with hydrogen halide, the sulphuric acid may serve to remove water, thus assisting in completion of the reaction].
[The process of the invention is applicable for hydrohalogenation, and especially for hydrobromination, of organic unsaturated compounds, particularly those of the olenfinic and acetylenic types. These include unsaturated aliphatic hydrocarbons, acids, alcohols, aldehydes, others, ketones and the like, as well as derivatives of these compounds, including sulphonated, nitrated, halogenated, 0r aryl-substituted bodies, etc., and the like. Compounds satisfactory for hydrohalogenation by the present process include propylene, decene-l, 5-chlorpentene-2, crotcnylene, isoprene, diallyl (hexadiene-l,5) allyl bromide, heptyne-l, styrene, vinyl acetylene, dehydro-undecylenic acid, beta-ethyl-acrylic acid, sorbic acid, linoleic acid, maleic anhydride, sinnamic acid, cyclopentadiene, allyl carbinol, citronellol, l-nitroisobutylene-Z, acrolein, propargylic aldehyde, crotyl ethyl ether, vinyl prODYl ketone, mesityl oxide, phorone, indene, etc. The process .with the sulphur dioxide solution of 3 of this invention is thus applicable for reacting a hydrogen halide with any organic compound capable of reacting with said hydrogen halide at similar temperatures] In contacting the styrene [unsaturated organic compound] with the liquid sulphur dioxide solution of hydrogen halide, it has been found convenient to run the liquid styrene [organic compound, if liquid,] into the sulphur dioxide solution while agitating, [or, if the organic compound is gaSeOus, to bubble it through the sulphur dioxide solution]. [The organic compound, if solid, may be added directly to the liquid sulphur dioxide solution and may be dissolved or suspended therein, or it may be liquefied prior to admixture by the use of heat and/or of solvents] However, it will be understood from the foregoing that the mixture may also b made by running the sulphur dioxide solution of hydrogen halide into the styrene [organic compound] to be hydrohalogenated or the two bodies may be passed in countercurrent to eachother in continuous operation]. [Such countercurrent contact is of particular convenience where the or ganic compound is gaseous and can be bubbled upward througha downwardly moving columnof the sulphur dioxidesolution of hydrogen halide} Similarly, although it ispreferred to prepare the hydrogen halide in the manner disclosed, it is also contemplated'that the styrene [unsaturated organic reactant] may be dissolved' in liquid sulphur dioxide and that the hydrogen halide may thereafter be added to the liquid sulphur dioxide solution thus formed. The hydrogen halide may be passed in the gaseous state into said solution or may be run into the solution in liquefied form or dissolved in liquid sulphur dioxide or in an organic solvent.
The or anic reactants may advantageously be dissolved in-another inert solvent for admixture the hydrogen halide especially where the reactant is insoluble or only slightly soluble in liquid sulphur dioxide]. The reaction mixture may thus be of either one or two liquid phases, and it is preferred that the solvent selected be at least partly miscible with liquid sulphur dioxide. Suitablesolvents or suspending media for the unsaturated organic reac'tant include [butane, pentane, hexane, decane and other alkanes; carbon tetrachloride, chloroform, ethylene dichloride, ethyl bromide, dichloro-difluoromethane, and other halogenated hydrocarbons; cyclohexane; decalin, tetralin and other cycloaliphatics; benzene, toluene, the xylenes, naphthalene, diphenyl, nitrobenzene and other aromatic hydrocarbons together with their n-itro-, halogeno-, and other derivatives; petroleum etherand gasoline; liquid-carbon dioxide; liquidsulphur dioxide;] ethyl ether, dioxaneand other ethers; [carbon disulphidefl and the like,
and mixtures thereof.
The contact of the styrene [organic reactant] with the liquid sulphur dioxide solution of the hydrogen halide is preferably aided by agitation, especially where more than one phase is present. The time of contact varies appreciably, [depend ing upon the compound to be hydrohalogenated,] but it has-been observed that high yields are obtainable with most reactants after about fifteen to about thirty minutes, and in some cases in even shorter time. Similarly, the proportions of the styreneIorganic reactant] to the hydrogen halide may vary widely, [especially for different degrees of hydrohalogenation where poly-unsaturated or acetylenic groups are reacted]. The
reaction temperatures and pressures may also be varied within wide limits again depending upon the compound to be reacted and the product to be formed]. In general, it is preferred to carry out the reaction at temperatures around -10 C.
i keep, the sulphur dioxide in the liquid state.
When the operation is carried out at tempera tures and pressures and/or under other conditions which remove substantial amounts of the sulphur dioxide through volatilization or otherwise, it is desirable to provide for the addition of sufficient liquid. sulphur dioxide to the reaction mixture in order that the volume may be appropriately adjusted. In this manner, by regulation of the pressure, control oftemperatures can be obtained.
After-the reaction has pro-gressedto the desired degree, the sulphur dioxide is removed from the reaction mixture. This may be accomplished by bubbling an inert gas, such as carbon dioxide, nitrogen, stack gases, etc., through the mixture, and/or by gradually pouring the mixture into ice water or'upon ice, during which operation mostof the liquidsulphur dioxide volatilizes, and/or by other means. Suitable equipment may be provided for carrying out these operations, whereby the volatility of the sulphur dioxide may be increased, as by reducing the pressure'in the system. Such equipment may also be provided with condensers, whereby'the volatilized sulphur dioxide and/or other solvent employed may be recovered for reuse. In many cases, the nature of the product formed is such that its temperature may be increased. without deleterious effect, so that most or all of the remaining solvent may be removed from the reaction mixture by heating or the like. Known methods, including fractional distillation, fractional crystallization, extraction, and other separation procedures or any combination of these, may be employed for separating the product from the aqueous mass and/or from unreacted materials.
The eifect of oxidation upon styrene [olefines and other unsaturated bodies] is a deleterious one for the present purpose since, in the presence of peroxides, olefines and substituted olefines give polymeric sulphones with sulphur dioxide]. It has therefore been found to be of advantage to use freshly prepared and/or freshly distilled styrene [olefinic and acetylenic compounds] substantially free from peroxides and/or to add antioxidants to the mixtures before hydrohalogenating. Suitable anti-oxidants include [stannous chloride,] hydroquinone, pyrocatechin, [decahydronaphthalene,] etc. By excluding substantially all peroxides and other oxidizing agents, it is possible to obtain a substantially homogeneous reaction product, as, when operating at the normally low temperatures of the present process, the addition of hydrogen bromide (or hydrogen chloride) generally follows Markownikoifs rule almost quantitatively, the negative radicle (Cl or Br) being attached to the carbon having fewer hydrogen atoms or the greater number of alkyl groups. [Where, in certain cases, the reverse is desired, higher temperatures at increased pressures may be employed] The following example is are] is given to illustrate the present invention and it will be apparent that the invention'is not limited thereto].
Example [I] About 250 cc. of liquid sulphur dioxide is tapped from an inverted cylinder of sulphur dioxide into a cylindrical, unsilveredDewar flask of about 1 liter capacity, open at the top, and provided with an electric stirrer and with a stop cock at its lower end. About grams of bromine are added to the liquid sulphur dioxide and are dissolved therein, the sulphur dioxide vapors acting as a blanket to keep atmospheric oxygen and moisture out of the vessel. About 16 grams of water are then slowly added with stirring until the reddish brown color of the bromine is discharged. A lower layer of sulphuric acid collects at the bottom of the Dewar flask upon standing and is permitted to remain there.
About grams of freshly distilled styrene is then run into the sulphur dioxide solution in the flask, and the mixture is stirred for about thirty minutes at about 8 C. At the end of this period, substantially none of the hydrogen bromide remains in the sulphur dioxide solution. A current of carbon dioxide is then passed through the reaction mixture to evaporate a major portion of the liquid sulphur dioxide, and the mixture is thereafter run into cracked i e and water. When most of the sulphur dioxide has volatilized, the residue is extracted with petroleum ether and is washed free of acids with water, the first portions of wash water used containing a small amount of sodium hydroxide. The petroleum ether is then evaporated to yield about 39.4 grams of alpha-bromoethylene as a colorless, harsh-smelling liquid. The produce obtained distills at about 64 C. to about 66 C. at a pressure of 8 mm. of mercury, and the amount obtained is equivalent to about 86.5% of the calculated theoretical yield.
The structure of the product is confirmed by reacting a portion thereof with sodium acetate in acetic acid to form an acetate which, after saponification, yields an alcohol boiling at about 201 C. The alcohol, by conversion to the 3,5- dinitrobenzoate melting at about 92 C. to 95 C., is proven to be alpha-phenylethyl alcohol. A portion of this alcohol is oxidized with chromic acid to obtain acetophenone, recognized by the semicarbazone melting at about 196 C. It thus appears that hydrogen bromide can be added to styrene, in accordance with the procedure of the present invention, and follows the Markownikofi rule to give alpha-bromoethylbenzene.
[Example II] to evaporate sulphur dioxide, and the product is extracted with petroleum ether, dried and distilled. The product comprises bromophenylpropionic acid.]
[Example III] [To a solution of about grams of hydrogen bromide in about 250 cc. of sulphur dioxide at for about thirty minutes.
about 20 C. and at a pressure of about 4 atmospheres, about 55 grams of freshly distilled allyl bromide at about 20 C. is slowly added. The reaction mixture is agitated for about fifteen minutes. Nitrogen gas is then bubbled through the reaction mixture, which is then poured into ice water to volatilize the major portion of the sulphur dioxide, and thereafter the entire mass is distilled to remove residual sulphur dioxide, unreacted allyl bromide and water. The residue, boiling at about C. to 142 C., comprises 1,2- dibrompropane] [Example IV] [About 14 grams of freshly distilled acrolein are slowly added to a solution of about 25 grams of anhydrous hydrogen bromide in about cc. of liquid sulphur dioxide in a Dewar flask. After about twenty minutes of stirring, the reaction is completed. The sulphur dioxide is removed from the reaction mixture, following the procedure set forth in Example I, and alpha-bromopropiorialdehyde is recovered. A high yield is obtained, which is apparently ascribable to being able to maintain the reaction temperature at the low temperature of liquid sulphur dioxide and thus substantially to eliminate side reactions] [Example V] [About 20 grams of chlorine are dissolved in about 250 cc. of liquid sulphur dioxide, and water is slowly added to form hydrogen chloride in situ. About 50 grams of indene are run into this solution, and the mixture is 'mechanically agitated At the end of this time, the temperature is gradually increased, and the sulphur dioxide is distilled off. The reaction mass is then extracted with carbon tetrachloride and is further distilled, alpha-chlorindane being obtained therefrom] [Example VI] [About 23 grams of freshly distilled propargyl alcohol are slowly added to an anhydrous solution of about 40 grams of hydrogen bromide in about 250 cc. of liquid sulphur dioxide. The mixture is stirred for about fifteen minutes, and the mixture is then poured into ice water. The aqueous mass is extracted with carbon tetrachloride and is distilled, bromo-allyl alcohol being obtained] [Example VII] [An anhydrous solution of about 90 parts by weight of hydrogen bromide per hour dissolved in about 600 parts of liquid sulphur dioxide per hour are run slowly downward through a column. At a point above the lowest portion of the column, about 30 parts of ethylene per hour are passed into the column and are bubbled through the downwardly flowing solution. The reaction product is removed at the bottom of the column together with liquid sulphur dioxide, from which it is separated and recovered. The unreacted ethylene and volatilized sulphur dioxide are withdrawn at the top of the column. The product comprises ethyl bromide] [Example VIII] [About 42 grams of freshly distilled ethylene oxide are mixed into an anhydrous solution of about 80 grams of hydrogen bromide in liquid sulphur dioxide. Following the procedure as set forth in Example I, ethylene bromohydrin is obtained as a product] stituted acids.
7 [Example IX] [About 50 grams of freshly distilled propyl cyanide are slowly added with stirring to an anhydrous solution of about .80 grams of hydrogen bromide in liquid sulphur dioxide. The procedure of Example I is followed, and a product comprised propyl imino-bromide is obtained] The use of anhydrous hydrogen halide for these reactions is of considerable advantage in obtaining high yields and high quality of product. Liquid sulphur dioxide has many advantages as a solvent for the reactants, being inexpensive, easily removable, non-corrosive and noninfiammable and having a, low boiling-point. Close controlv of reaction temperatures, ordinarily unattainable or attainable only with great difliculty, can be easily maintained in liquid sulphur dioxide, especially with regulation of pressure.
[Other reactions utilizing'a hydrogen halide in liquid sulphur dioxide, and preferably anhydrous hydrogen halide prepared in the manner disclosed herein, may also be carried out. The same procedure as shown here for hydrohalogenation of various organic compounds can be followed, or such procedure may be modified, depending upon conditions to be met and operative expediency.
7, Thus, hydrogen bromide in liquid sulphur dioxide may be employed in double decomposition and substitution reactions. Alkyl halides may be formed by contacting alcohols with a hydrogen halide in liquid sulphur dioxide. In like manner, hydroxyl substituted aliphatic acids may be added to solutions of a hydrogen halide in sulphur dioxide to form the correspondin halogen-sub- Hydrogen bromide in liquid sulphur dioxide can also be used as an esterification catalyst for influencing the reaction of an organic carboxylic acid with an alcohol to form an ester. Similarly, aryl halides can be formed by reaction of a hydrogen halide in liquid sulphur dioxide with aryl diazonium halides in the presence of a suitable catalyst; thus, benzene diazonium chloride, when mixed with hydrogen bromide inthe presence of liquid sulphur dioxide and cuprous bromide as 'a, catalyst, gives a product comprising brombenzene] Although the present invention has been described with reference to particular embodiments and examples, it will be apparent to those skilled in the art that variations and modifications of this invention can be made and that equivalents can be substituted therefor without departing from the principles and true spirit of tion.
I claim:
[1. The process of reacting organic compounds with a hydrogen halide which comprises intimately contacting a hydrogen halide from the group consisting of hydrogen chloride and hydrogen bromide With an organic reactant While at least one of said halide and said reactant is dissolved in liquid sulphur dioxide] [2. The process of reacting organic compounds with a hydrogen halide which comprises reacting a hydrogen halide from the group consisting of hydrogen chloride and hydrogen bromide with an unsaturated organic compound in liquid sulphur dioxide medium] [3. The process of reacting unsaturated organic compounds with hydrogen bromide which comprises mixing a solution of anhydrous hydrogen bromide in liquid sulphur dioxide with an unsaturated organic compound capable of adding the inven- '8 hydrogen bromide, "and removing sulphur "dioxide from said mixture] [4. The process of reacting organic compounds with hydrogen bromide which comprises preparing a solution of anhydrous hydrogen bromide in liquid sulphur dioxide, -intimately contacting said solution with an organic compound having an unsaturated aliphatic group capable .of ad'ding hydrogen bromide, and removing sulphur dioxide from said mixture] [5. In the process of hydrobrominatingzan unsaturated organic "compound, the improvement which'comprises intimately contacting said compound with anhydrous hydrogen bromide while at least one of said reactants is dissolved 'in'liquid sulphurdioxide] [6. The improvement set forth in claim 5 wherein the unsaturated organic compound is freshly distilled] [7. The improvement set forth 'in claim 5 wherein the reactants are contacted in the pres- .ence of an anti-oxidant] [8. In the process of hydrobrominating anorganic compound having an unsaturated aliphatic group, the improvement which comprises preparing a solution of anhydrous hydrogen bromide in liquid sulphur dioxide, mixing said solution with said organic compound, removin sulphur dioxide from said mixture to leave a residue,,and recovering the addition product from said residue] [9. In the process of hydro'chlorinating an organic compound havin an unsaturated aliphatic group, the improvement which comprises ,preparing a solution of anhydrous hydrogen chloride in liquid sulphur dioxide, mixing said solution withsaid organic compound, removing sulphur dioxide from said mixture to leave a residue, and recovering the addition product from said residue] [10. In .the process of hydrobrominating anorganic compound having an unsaturated aliphatic group, the improvement which comprises preparing a solution of anhydrous hydrogen bromide in liquid sulphur dioxide, dissolving said organic compound in-a substantially inert solvent at least partially miscible with liquid sulphur dioxide to form a second solution, intimatelymixing said solutions, removing sulphur dioxide from said mixture to leave a residue, and recovering the addition product from said residue] .11. The process of reacting styrene with hy'drogen bromidewhich comprises contacting bromine in liquid sulphur dioxide medium with water'to produce hydrogen bromide and sulphuric acid, intimately contactin the resulting mixture of hydrogen bmmidasulphuric acid and-liquidsulphurdioxide with styrene, removing sulphur dioxide from said mixture, and recovering bromoethylbenzene from th 'residu'e.
12. The process of hydrobrominating styrene which comprises contacting bromine with water to produce hydrogen bromide and sulphuricacid in the presence of liquid sulphur dioxide medium, intimately contacting the resulting mixture of hydrogen bromide, sulphuric acid and liquid sulphur dioxide with styrene, "volatilizingsulphur dioxide from thereaction mixture, and recovering alpha-bromoethylbenzene from the residue.
. vZ-kR/I'IITJ'IR IRA GEBHART.
(References on followin'g page) 9 '10 2 REFERENCES CITED Number Name Date The following references are of record in the gi ggz gi ii g file of this intent or the orlgmal patent: 2:284:467 Ballard May 26, 1942 UNITED STATES PATENTS 5 2,339,330 Gebhart Jan. 18, 1944 Number Name Date 1,087,961 Masland Feb. 24, 1914 OTHER REFERENCES 1,518,182 Curms Dec. 9, 1924 Chemical Abstracts, vol. 17, page 748 (1923); 1,637,972 Suida, Aug. 2, 1927 abst, of article by Meerwein et a1.; ibid., vol. 29, ,4 u ting etal Dec. 25, 1934 19 001. 2465 (1935) abst. of article by Cornog et al. 2,031,228 Reilly Feb. 18, 1936 Smyth: Dielectric Constant and Molecular 2,099,480 Hjerpe Nov. 16, 1937 structure" (A. C. S. Monograph No. 55), pages 2,125,284 Chamberlain et a1. Aug. 2, 1938 13. 191-3.
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