USRE18719E

USRE18719E - Assionob

Info

Publication number: USRE18719E
Authority: US
Publication date: 1933-01-24

Description

Reiuued Jan. 24, 1933 UNITED STATES PATENT orrrca BENJAMIN I. EIOHER, OI CH IGAGO, ILLINOIS, ABSIGNOB, BY MESNE ASSIGNMENTS, TO

THE DR. GROSS LABORATORIB, INC., DAYTON, OHIO, A CORPORATION 01 DELL- WARE PROCESS FOR MAKING GOD-LIYER-OII: TABLETS Il'o Drawing. Original No. 1,552,549, dated September 8, 1925, herial No. 712,555, filed Kay 12, 1924.

Application for reissue flled January 15, 1928. Serialll'o. 81 569.

This invention relates to the manufacture of pills, more particularly pills having an oily material as one of the principal'ingredients.

5 One of the difficulties hitherto encountered in connection with makin pills is the incorporation with the other mgredients-of oily materials such as cod liver oil extractives, i. e. the ethereal, alcoholic and other well known extractives of the active components of cod liver oil.

It is an object, therefore, of the present invention to rovide an improved process for making pill more particularly pills having 5 an oil material as one of the dients.

Other and further important objects of the invention will be apparent from the disclosures in the followin description, which sets forth the preferred orm of the invention.

According to the preferred form of the invention reduced iron, zinc phosphide, berberine sulphate and strychnine sulphate are mixed in a ball'mill with suflicient charcoal to get a thorough mixture. The balance of the charcoal desired is then added and uniformly incorporated in the mixture. Then principal ingrea solution of oleoresin of ginger in ether is added and the whole thorou hly mixed. The next step is to reduce t e material into anular form which may conveniently be one by passin it through a screen. The granules so ma e are dried and then again passed through the screen and compressed 5 mto three an compression step the pressure should not be greater than is retl uired to make a coherent mass since the pil s should be rous to absorb a solution of cod-liver o1l extractives in a volatile solvent.

The ills after compression are placed in a perco ator and a solution of cod-liver oil extractives in about twice their wei ht of ether is poured over the pills. The so ution flowing through the percolator is caught and reone-half grain tablets. In the passed through the pills until all has beenabsorbed. The pills are then dried at a suitable temperature to remove the volatile solvent when they are ready to coat.

The pills may conveniently be coated in a pan with simple syrup. Next a thin coating of dry powdered (granulated) acacia is applied. The pills are dried and the coating operations are repeated. After further drying they are sugar coated brown or any other desired color.

The proportion ,of the ingredients used is preferably kept'within the following limits:

I Per cent Cod liver oil extractives 7 to 30' Reduced iron 1 to 8 Zinc 'phosphide 0.5 to 3 Berberine sulphate r 0.1 to 0.6

Strychnine sulphate 0.01 to 0.06 Oleoresin of ginger 0.1 to. 0.6 Powdered charcoal 5O to Proportions which have been found especially suitable are the following:

Various of these ingredients may be omitted if desired without changing the proc ess in any way. Further, other absorbent materials than charcoal may in some cases be :employed. Also other volatile solvents than ether may be used in certain cases.

It will also be evident that several of the numerous steps in the process may be omitted or modified without changing the essential principles of the invention. Thus in place of a percolator the pills and solution of codliver oil extractives might be placed in a tumbling barrel to incorporate the latter in the ills. A percolator is preferred, however, as there is less tendency to break the pills.

I am aware that numerous details of this process may be varied through a wide range without departin from the principles oi this invention, and therefore do not purpose limiting the patent granted, otherwise than necessitated by the prior art.

Having now described my invention, I claim 1. A process for making pills comprising forming charcoal pills, then applying to the pills a solution of cod liver oil extractives in a volatile solvent and evaporating the solvent.

forming charcoal pills, then applying to the pills a solution of cod-liver oil extractives in ether and evaporating the ether.

3. A process for making pills comprising .mixing charcoal with a solution of oleoresin phide, berberine sulphate and strychnine sulphate, and a solution of oleoresin of ginger in ether, granulating and drying the mixture, forming the dry mixture into pills by pressure, then applying to the pills a solution of cod liver oil extractives in ether and evapor-' ating the ether.

5. A method of forming a dry medicinal agent containing active extracted ingredients of cod-liver oil, which consists in causing a solution of said active ingredients to come into contact with a porous inert carrier which is insoluble in water, and allowing the solvent in said solution to evaporate at a suitable temperature.

. 6. A method of forming a dry medicinal agent containing active extracted ingredients of cod-liver oil, which consists in causing a solution of said active ingredients in ether to come into contact with a porous inert carrier which is insoluble in water, and allowing the solvent in said solution to evaporate at a suitable temperature.

7. A method of forming a dry medicinal agent in coherent tablet form and containing active extracted ingredients of cod-liver oil, which consists in causing connected particles of a porous inert carrier which is insoluble in water to contactwith a solution of said active ingredients, allowingthe solvent in said solution to evaporate at a suitable temperature, and binding said particles by a suitable binder whose action is efiective at a suitable temperature.

2. A process for making pills comprising 8. A medicinal. ent comprising a porous inert carrier insold le in water and containing the absorbed residue from an evaporated sollution of the active ingredients of cod-liver o1 9. A medicinal agent comprising tablet' made of particles of a porous inert carrying material insoluble in water, said carrying material containing the absorbed residue gradients, forming the mixture into pill form,

applying to the pills thus formed a solution of cod liver oil extractives in ether, and evapo rating the ether.

12. The method of makin pills which comprises mixing together medicinal ingredients with a sufiicient volume of an inert absorbent material insoluble water to enable a thorough mixture, then addin more of said absorbent material and uni ormly incorporatin the same in the mixture, then adding a so ution of a binding ingredient in a volatile solvent and thoroughly mixing the whole, forming the final mixture into pill form with just enough pressure to produce a coherent mass for each pill, so as not to destroy its porosity, then treating the pills thus formed with a solution of cod liver oil extractives in a volatile solvent, and evaporating the solvent.

13. A method of making cod liver oil pills comprisin forming the pills from a mass 0 an inert a sorbent material insoluble in water, and in which a solution of cod liver oil extractives is absorbed. V

14. A medicinal agent in tablet form and composed of an inert and absorbent excipient which is insoluble in water, and an absorbed extractive of cod liver oil contained in said exc'ipient.

15. A process for makin mixing charcoal with mediclnal ingredients, forming the mixture into pill form, then applying to the pills a solution of an ingredient containing the therapeutic principles of cod liver oil in a volatile solvent, and evaporating the solvent.

16. A process for making pills comprising forming pill bodies of an inert absorbent material insoluble in water, then applying to the pills a solution of a medicinal ingredient containing extractives of cod liver oil in a volatile solvent, and evaporating the solvent.

ills comprising 17. The process of preparing cod liver oil in pill or tablet form comprisl 1provi a solution of there utic princi es of liver oil in a volati e solvent,- an absorbing 6 said solution in an inert absorbent exoipient insoluble in water and from which the pills or tablets are formed, and allowing the solvent to evaporate, so that said therapeutic principles are retained in the exci iient sub- 10 stance after evaporation of the v0 atile solvent.

In witnes whereof I hereunto subscribe my name to this specification. Y

15 "BENJAMIN L. EICHER. l