USRE15127E - Compounds op cinchona alkaloids and z-phenyl-qtjinolin-x-carboxylic - Google Patents
Compounds op cinchona alkaloids and z-phenyl-qtjinolin-x-carboxylic Download PDFInfo
- Publication number
- USRE15127E USRE15127E US15127DE USRE15127E US RE15127 E USRE15127 E US RE15127E US 15127D E US15127D E US 15127DE US RE15127 E USRE15127 E US RE15127E
- Authority
- US
- United States
- Prior art keywords
- phenyl
- carboxylic
- compounds
- qtjinolin
- cinchona alkaloids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930013930 alkaloids Natural products 0.000 title description 4
- 241000157855 Cinchona Species 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 title description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000003797 alkaloid derivatives Chemical class 0.000 description 2
- QMQXAQUBDPFOSS-UHFFFAOYSA-N 2-phenyl-1H-quinoline-2-carboxylic acid Chemical compound N1C2=CC=CC=C2C=CC1(C(=O)O)C1=CC=CC=C1 QMQXAQUBDPFOSS-UHFFFAOYSA-N 0.000 description 1
- 240000000800 Allium ursinum Species 0.000 description 1
- YTRMTPPVNRALON-UHFFFAOYSA-N Cinchophen Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=CC=C1 YTRMTPPVNRALON-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- -1 quinin Chemical class 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
Definitions
- the invention relates to a combination of a cinchona alkaloid, particularly quinin,
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
UNITED STATES PATIENT OFFICE.
ALEX n. DAVIS, or CINCINNATI, OHIO, assmnon. 1'0 THE ELI LILLY AND corrimny,
OF INDIANAPOLIS, INDIANA, A. CORPORATION OF INDIANA.
COMPOUNDS or omcnolu ALKALOIDS AND B-PHENYL-QUINOLIN-4-CABBOXYLIC p ACID.
Specification of Reissued Iletters Patent. Reissued June 21, 1921. No Drawing. Original Nb. 1,213,464, dated January as, 1917, Serial no. 102,310, filed June 7, 1916.
Application for reissue-filed May 5, 1921. Serial No. 468,142.
To all whom it may concern Be it known that I, ALEX B. DAVIS, a citizen of the United States, residing at Gin cinnati, Hamilton county, and State of Ohio, (formerly a resident of Indianapolis, Indiana,) have invented and discovered certain new and useful Improvements in Comounds of Cinchona. Ailkaloids and Q-Phenyl- 5uinolin-4-Carboxylio Acid, of which the following is a specification.
The invention relates to a combination of a cinchona alkaloid, particularly quinin,
solution of 124.5 rams of 2-phenyl-quino- 1in-4-carboxylic acld in 800 c. c. of water and 'ust sufiicient caustic soda to neutralize it.
he uinin-compound quickly separates as a stic y mass which quickly solidifies to a mass of crystals. The. mass is broken up,
filtered from the water, washed with water and dried at a low temperature, when it appears as anearly tasteless white, crystalline powder, almost insoluble in water, decomposed byalkalis, soluble in hot acetone and alcohol.
What I claim is: 1
1. Acompound ofacinchona alkaloid and 2-phenyl-quinolin-4-carboxylic acid.
2. A compound of quininand 2-phenylquinolin--carboxylic acid.
In witness whereof, I have hereunto set my hand at Cincinnati, Ohio, this 14th. day
of April, 1921.
- ALEX B. DAVIS. Witnesses:
P. G. Gnome, EMILY F. Seam.
Publications (1)
Publication Number | Publication Date |
---|---|
USRE15127E true USRE15127E (en) | 1921-06-21 |
Family
ID=2075705
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15127D Expired USRE15127E (en) | Compounds op cinchona alkaloids and z-phenyl-qtjinolin-x-carboxylic |
Country Status (1)
Country | Link |
---|---|
US (1) | USRE15127E (en) |
-
0
- US US15127D patent/USRE15127E/en not_active Expired
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