US9222470B2 - Micropump - Google Patents

Micropump Download PDF

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Publication number
US9222470B2
US9222470B2 US13/635,010 US201113635010A US9222470B2 US 9222470 B2 US9222470 B2 US 9222470B2 US 201113635010 A US201113635010 A US 201113635010A US 9222470 B2 US9222470 B2 US 9222470B2
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Prior art keywords
rotor
cam
inlet
pump
outlet
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US13/635,010
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US20130017099A1 (en
Inventor
Dominique GENOUD
Peter Christen
Franck Robin
Helmut Thiemer
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Sensile Medical AG
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Sensile Pat AG
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Assigned to SENSILE MEDICAL AG reassignment SENSILE MEDICAL AG CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: SENSILE PAT AG
Assigned to SENSILE MEDICAL AG reassignment SENSILE MEDICAL AG CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: SENSILE PAT AG
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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B7/00—Piston machines or pumps characterised by having positively-driven valving
    • F04B7/04—Piston machines or pumps characterised by having positively-driven valving in which the valving is performed by pistons and cylinders coacting to open and close intake or outlet ports
    • F04B7/06—Piston machines or pumps characterised by having positively-driven valving in which the valving is performed by pistons and cylinders coacting to open and close intake or outlet ports the pistons and cylinders being relatively reciprocated and rotated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/14216—Reciprocating piston type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B7/00—Piston machines or pumps characterised by having positively-driven valving
    • F04B7/04—Piston machines or pumps characterised by having positively-driven valving in which the valving is performed by pistons and cylinders coacting to open and close intake or outlet ports
    • F04B7/045—Two pistons coacting within one cylinder
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B9/00—Piston machines or pumps characterised by the driving or driven means to or from their working members
    • F04B9/02—Piston machines or pumps characterised by the driving or driven means to or from their working members the means being mechanical
    • F04B9/04—Piston machines or pumps characterised by the driving or driven means to or from their working members the means being mechanical the means being cams, eccentrics or pin-and-slot mechanisms
    • F04B9/042—Piston machines or pumps characterised by the driving or driven means to or from their working members the means being mechanical the means being cams, eccentrics or pin-and-slot mechanisms the means being cams
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B9/00—Piston machines or pumps characterised by the driving or driven means to or from their working members
    • F04B9/02—Piston machines or pumps characterised by the driving or driven means to or from their working members the means being mechanical
    • F04B9/04—Piston machines or pumps characterised by the driving or driven means to or from their working members the means being mechanical the means being cams, eccentrics or pin-and-slot mechanisms
    • F04B9/047—Piston machines or pumps characterised by the driving or driven means to or from their working members the means being mechanical the means being cams, eccentrics or pin-and-slot mechanisms the means being pin-and-slot mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M2005/16863—Occlusion detection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/36—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body

Definitions

  • micropump that is particularly cost effective to manufacture, such that it could be provided as a disposable system.
  • a pump comprising a housing, comprising a rotor chamber, inlet and outlet channels opening into the rotor chamber, and inlet and outlet seals mounted on a surface of the chamber, and a rotor rotatably and axially slidably received in the chamber and comprising a first axial extension comprising a liquid supply channel and a second axial extension comprising a liquid supply channel, the first and second axial extensions having different diameters.
  • the inlet and outlet seals engage a surface of the rotor, whereby the liquid supply channel of each axial extension in conjunction with a corresponding seal forms a valve that opens and closes as a function of the angular and axial displacement of the rotor.
  • At least one of the inlet and outlet channels opens transversely or radially into the rotor chamber and at least one of the inlet and outlet seals forms a closed circuit circumscribing said at least one of the inlet and outlet channels.
  • both inlet and outlet channels open transversely into the rotor chamber and both inlet and outlet seals each forms a closed circuit circumscribing respective inlet and outlet channels.
  • the surface circumscribed by either the inlet or the outlet seal preferably wraps around the corresponding rotor extension over an angle ( ⁇ , ⁇ ) less than 180°.
  • the rotor is configured to oscillate over a rotation angle less than 360°, a back and forth movement constituting a pumping cycle.
  • the rotor is configured to rotate in a single direction, a rotation angle of 360° constituting a pumping cycle.
  • the rotor and housing may comprise inter-engaging cam elements to effect the rotor axial displacement as a function of the rotation angle.
  • said cam elements comprising a double sided cam slot.
  • the double sided cam slot may have a varying width in a variant configured to enable leakage or occlusion detection.
  • the axial displacement during pump filling may be defined by a cam section on one side of the cam slot, and the axial displacement during pump expelling defined by a cam section on an opposite side of the cam slot, the opposing cam surfaces acting as reference surfaces that accurately define the volume of pumped liquid at each cycle.
  • the cam slot comprises a first portion defining the axial displacement in one rotation direction, and a second portion defining the axial displacement in an opposite rotation direction.
  • the cam slot may advantageously comprises a step down or a point of no return configured to ensure that a complementary cam finger progresses from one cam slot portion to the other cam slot portion.
  • the rotor Before the cam profile setting, the rotor may be rotated in a reverse direction until a cam shoulder abuts a complementary cam finger, thus setting a defined reference starting position.
  • Also disclosed herein is a method of removing gas bubbles or detecting leakage in a pump comprising a housing portion and an axially and rotatably movable rotor portion mounted in the housing portion and having an inlet valve (V 1 ) and an outlet valve (V 2 ), the method including applying a back and forth displacement of the rotor over an angle less than 180° while applying an axial force on the rotor.
  • the back and forth displacement of the rotor occurs when both valves (V 1 , V 2 ) are closed, preferably over an angle less than 90°.
  • a pump disclosed herein may in particular be adapted for medical applications, including for the administration of liquid medicaments.
  • FIG. 1 a is a cross-sectional view of a pump module according to an embodiment of the invention.
  • FIGS. 1 b and 1 c are exploded perspective views of the module of FIG. 1 a with the housing illustrated as partially transparent to better view the rotor therein;
  • FIG. 1 d is a cross-sectional view through line 1 d - 1 d of FIG. 1 a and FIG. 1 e is a cross-sectional view through line 1 e - 1 e of FIG. 1 a;
  • FIGS. 2 and 3 are perspective views of a rotor pump module according the variants of the invention.
  • FIGS. 4 a to 4 f are perspective views of a rotor and housing of a pump module according to an embodiment of the invention, the housing being shown as partially transparent in order to better view the rotor therein, the different views 4 a to 4 f illustrating different rotational and axial position of the rotor relative to the housing to illustrate the pumping function of this embodiment, which relates to a rotor that rotates less than a full 360° in one direction or the other in an oscillating movement;
  • FIGS. 5 a to 5 f are illustrations similar to FIGS. 4 a to 4 f but of another embodiment of the invention corresponding to a rotor rotating a full 360° in one direction to perform a pumping cycle;
  • FIG. 6 is a perspective view of a pump module according to a variant with a single sided cam defining the rotor axial movement
  • FIG. 7 is a detailed perspective partial view of a double sided cam variant
  • FIG. 8 is a perspective view of a rotor with a double sided cam according to a variant of the invention.
  • FIG. 9 a is a graph illustrating the axial displacement (stroke) of the pump rotor as a function of the angular displacement of the rotor for a normal operating condition
  • FIG. 9 b is a graph similar to FIG. 9 a illustrating a leakage condition of the pump
  • FIG. 9 c is a graph similar to FIG. 9 a illustrating a leakage condition downstream of the pump
  • FIG. 9 d is a graph similar to FIG. 9 a illustrating a partial occlusion condition
  • FIG. 9 e is graph similar to FIG. 9 a illustrating a complete occlusion condition
  • FIG. 9 f is a graph similar to FIG. 9 a illustrating a leakage condition of the pump detected by performing a wobbling movement of the rotor;
  • FIG. 10 is a graph illustrating the axial displacement (stroke) of the pump rotor as a function of the angular displacement of the rotor for a variant with a double sided cam and a rotor displacement of 360° in one direction (embodiment of FIGS. 5 a to 5 f );
  • FIG. 11 is a graph illustrating the axial displacement of an oscillating pump rotor with a double sided cam according to an embodiment as a function of the angular displacement of the rotor.
  • FIGS. 12 a - 12 e are graphs illustrating the axial displacement of an oscillating pump rotor with a double sided variable slot width cam according to an embodiment of the invention that allows detection of leakage or occlusion, where FIG. 12 a illustrates a normal condition, FIG. 12 b illustrates a leakage condition in the pump, FIG. 12 c illustrates a leakage condition downstream of the pump, FIG. 12 d illustrates an occlusion condition, and FIG. 12 e illustrates a leakage condition of the pump detected by performing a wobbling movement of the rotor.
  • an embodiment of a pump module 2 comprises a housing 4 and a rotor 6 rotatably mounted in the housing.
  • the rotor comprises a first axial extension 14 having a generally cylindrical shape and a second axial extension 16 also having a generally cylindrical shape.
  • the first axial extension has a diameter D 1 that is greater than a diameter D 2 of the second axial extension.
  • the housing 4 comprises a rotor housing portion 8 comprising a chamber 10 , 12 , within which the rotor is mounted, the rotor chamber comprising a first portion 10 for housing the first axial extension 14 and a second portion 12 for housing the second axial extension 16 of the rotor, the first portion having a larger diameter than the second portion.
  • the housing further comprises an inlet channel 26 opening into the second chamber portion, configured to be connected to a liquid supply conduit or reservoir, and an outlet channel 28 for the pumped liquid to exit, opening into the first chamber portion.
  • both the inlet and outlet channels open transversely or radially into the chamber 10 , 12 (as opposed to extending from axial ends of the chamber).
  • one of either the inlet channel or the outlet channel may extend from an axial end of the chamber.
  • the pump may be configured such that the inlet and outlet channels described herein are inversed, namely that the inlet opens into the larger diameter first chamber portion and the outlet opens into the smaller diameter second chamber portion.
  • the pump may be configured to pump liquid from the large diameter portion towards the small diameter portion, or inversely may be configured to pump liquid from the small diameter portion towards the large diameter portion.
  • the pump may be configured according to the other variant.
  • the housing further comprises an inlet seal 20 surrounding the inlet channel 26 and mounted on a surface 29 of the chamber portion into which the inlet channel opens, and an outlet seal 18 surrounding the outlet channel 28 and mounted on a surface 27 of the chamber portion into which the outlet channel opens.
  • the inlet seal 20 forms a closed circuit circumscribing the inlet 26 and the outlet seal 18 forms a closed circuit circumscribing the outlet 28 .
  • the outlet and inlet seals are configured to sealingly engage respective surfaces 31 , 33 of corresponding first and second axial extensions of the rotor.
  • the surface circumscribed by either the inlet or the outlet seal wraps around the corresponding rotor extension over an angle ( ⁇ , ⁇ ) that is preferably less than 180°.
  • Liquid supply channels 22 , 24 are provided in the first and second axial extensions of the rotor.
  • the liquid supply channels 22 , 24 may be in the form of depressions on the surface of the respective extensions, the depressions extending generally axially but at a slightly oblique angle with respect to the axial direction as defined by the direction of the axis of rotation of the rotor.
  • the liquid supply channels may thus each wrap slightly around the respective rotor extension 14 , 16 in a helical manner as illustrated.
  • the liquid supply channels may be embedded within the rotor and have orifices (inlet, outlet) 22 ′, 24 ′ on the surfaces of the extensions.
  • the liquid supply channels may be in the form of axially extending grooves 22 ′′, 24 ′′ at the rotor surface. It is also possible to combine the features of the above two variants such that one of the liquid supply channels on one rotor extension is a depression or groove on the surface of the rotor and the other liquid supply channel on the other rotor extension is embedded within the rotor and has an outlet and an inlet opening onto the rotor surface.
  • the liquid supply channels 22 , 24 and seals 18 , 20 are configured to form an outlet valve V 2 and an inlet valve V 1 that open and close the outlet and inlet channels as a function of the rotor axial and angular position relative the housing.
  • the inlet and outlet channels in the housing do not need to be aligned as illustrated but may be positioned relative to each other at any angle around the rotor, the liquid supply channels in the rotor extensions being positioned accordingly. It is understood that the shape, position and size of the seals and the shape, position and size of the liquid supply channels may vary considerably without departing from the scope of the invention, the essential function being to open and close the valves and to avoid both valves being open simultaneously.
  • the inlet and outlet seals 20 , 18 may be formed as separate elements assembled in the housing, or as elements formed integrally with the housing, for instance injection molded in the housing.
  • the seals may for instance be injected from silicone-based or thermoplastic elastomers or rubber in a two-component single injection molding process with the housing.
  • Sealing rings 41 , 43 may be provided around first and second extensions of the rotor on outer sides of the inlet and outlet valves in order to seal the liquid filling part of the rotor chamber 23 .
  • These sealing rings may be in the form of O-ring seals or other seals mounted or injected in the housing or on the rotor.
  • the rotor 6 may be driven by any appropriate motor (not shown).
  • the rotor may comprise a motor portion (not shown) with one or more permanent magnets providing one or more magnetic poles, driven in rotation by electromagnets in a motor stator portion (not shown).
  • the motor stator portion may either be part of the pump, or part of a separate base unit into which the pump module is removably mounted.
  • the base unit can be provided with electronics for controlling and operating the pump and/or for transmitting signals to a control unit via a wireless or wired link.
  • the base unit may be configured as a reusable unit to which the pump module is removably mounted such that the pump module may be disposed of and replaced.
  • the axial displacement of the rotor may be performed by a magnetic or electromagnetic drive, or by a magnetic or spring biasing force combined with a cam system.
  • a single sided cam system 35 , 37 on the rotor 6 and housing 4 in conjunction with a spring or a magnetic biasing force BF is known per se in the prior art and illustrated in FIG. 6 .
  • the axial displacement of the rotor may also be effected by means of a double-sided cam, according to an advantageous aspect of an embodiment of the invention, as illustrated in FIGS. 1 a to 1 c , 7 , 8 and 10 to 12 .
  • the rotor may be provided with a cam slot or grove 38 , 38 ′, 38 ′′ defining opposing cam surfaces 40 a , 40 b , 40 a ′, 40 b ′, 40 a ′′, 40 b ′′.
  • a complementary cam finger 36 engaging in the cam slot or grove 38 , 38 ′, 38 ′′ is provided on the housing.
  • the cam finger 36 may be rigidly attached to the housing, either integrally formed therewith or as a separate part assembled to the housing.
  • the cam finger may be elastically mounted in the housing such that it presses down into the rotor cam slot.
  • An alternative variant (not shown) may comprise a cam finger on the rotor engaging in a cam slot provided in the housing to impart an axial movement on the rotor relative to the housing as a function of the angular movement of the rotor relative to the housing.
  • a cam finger mounted on the housing engaging in a cam slot of the rotor will be described herein on the understanding that the cam elements may be inversed.
  • the cam slot may comprise a single slot extending fully around the rotor for the embodiment where the rotor rotates 360° for the pumping action (embodiment of FIGS. 4 a to 4 f and FIG. 10 ), or a two-portion slot extending only partially around the rotor for an oscillating rotational movement (embodiment of FIGS. 1 a - 1 c , 8 , 10 - 12 ).
  • the opposing cam surfaces 40 a , 40 b , 40 a ′, 40 b ′, 40 a ′′, 40 b ′′ of the cam slot 38 , 38 ′, 38 ′′ may either define a slot of essentially constant width ( FIG. 1 a - 1 c , 11 ), or may define a cam slot of varying width ( FIGS. 8 , 10 and 12 ).
  • the cam slot may thus either have opposing cam surfaces that conform to the cam finger as illustrated in FIG.
  • the cam slot may have opposed cam surfaces 40 a , 40 b , 40 a ′′, 40 b ′′, that are separated by a varying spacing that is configured to enable leakage or occlusion detection as will be described in more details further on in relation to FIGS. 9 a - 9 f , 10 and 12 .
  • the cam slot may comprise a first portion 39 a corresponding to a first rotation direction, and a second portion 39 b corresponding to a second rotation direction opposite to the first.
  • FIGS. 5 a to 5 f an embodiment of a pump module with a 360° rotating rotor is illustrated.
  • the rotor rotates in a single direction R+ for the pumping action.
  • the rotor may also rotate in the reverse direction in order to perform a reverse pumping operation, whereby in such a variant the axial displacement cam is configured to allow rotation in both directions.
  • the rotor is in a position corresponding to the valves V 1 and V 2 both in a closed position.
  • the outlet valve V 2 is formed by the outlet seal 18 , outlet canal 28 , first axial extension 14 and first liquid supply channel 22
  • the inlet valve V 1 is defined by the cooperation of the inlet seal 20 , inlet canal 26 , second axial extension 16 and second liquid supply channel 24 .
  • the rotor is angularly and axially positioned such that neither of the liquid supply channels 22 , 24 are found within the surface area 19 , 21 circumscribed by the respective seals (hereinafter referred to as the “in-seal zones”).
  • the rotor shown is rotating in the clockwise direction, with the FIGS. 5 a to 5 f showing successive positions in a 360° pump cycle.
  • the inlet valve V 1 opens when the liquid supply channel 24 enters into the inlet in-seal zone 21 circumscribed by the inlet seal 20 .
  • the rotor turns and the inlet valve V 1 opens, the rotor is also axially displaced such that the free volume 23 in the chamber increases and draws liquid Fi in through the inlet valve V 2 to fill the chamber free volume 23 .
  • Outlet valve V 2 is closed during the chamber filling process that continues as illustrated in FIG. 5 c until the inlet valve V 1 closes as illustrated in FIG. 5 d , the outlet valve V 2 being closed throughout the chamber filling process.
  • the outlet valve V 2 opens when the liquid supply channel 22 engages in the outlet in-seal zone 19 circumscribed by the outlet seal 18 .
  • the outlet valve V 2 When the outlet valve V 2 is open, the rotor axially displaces in the direction that reduces the chamber free volume 23 thus expelling liquid Em through the outlet canal 28 , as also shown in FIG. 5 f .
  • the inlet valve V 1 is closed throughout the chamber emptying process.
  • the outlet valve V 2 then closes as the rotor completes a 360° cycle to the position shown in FIG. 5 a.
  • the rotor may be rotated in the reverse direction to pump liquid in the reverse direction (the inlet becomes the outlet and vice versa), the axial displacement cam being configured accordingly to allow rotation in both directions.
  • FIGS. 4 a to 4 f an oscillating rotor is illustrated.
  • both valves V 1 are V 2 are closed.
  • the outlet valve V 2 is formed by the outlet seal 18 , outlet canal 28 , first axial extension 14 and first liquid supply channel 22
  • the inlet valve V 1 is defined by the cooperation of the inlet seal 20 , inlet canal 26 , second axial extension 16 and second liquid supply channel 24 .
  • the rotor is angularly and axially positioned such that neither of the liquid supply channels 22 , 24 are found within the surface area 19 , 21 circumscribed by the respective seals.
  • FIG. 4 b after a certain rotation from the closed valves position of FIG. 4 a , the inlet valve V 1 opens because the liquid supply channel 24 enters into the inlet in-seal zone 21 circumscribed by the inlet seal 20 . As the rotor turns and the inlet valve V 1 opens, the rotor is also axially displaced such that the free volume 23 in the chamber increases and draws liquid Fi in through the inlet valve V 2 to fill the chamber free volume 23 .
  • Outlet valve V 2 is closed during the chamber filling process that continues as illustrated in FIG. 4 c until the inlet valve V 1 closes as illustrated in FIG. 4 d , the outlet valve V 2 being closed throughout the chamber filling process.
  • the rotor stops and then rotates in the opposite direction R ⁇ (counterclockwise in this example) until the outlet valve V 2 opens as illustrated in FIG. 4 e , when the liquid supply channel 22 engages in the outlet in-seal zone 19 circumscribed by the outlet seal 18 .
  • the outlet valve V 2 is open, the rotor axially displaces in the direction that reduces the chamber free volume 23 thus expelling liquid Em through the outlet canal 28 , as also shown in FIG. 4 f .
  • the inlet valve V 1 is closed throughout the chamber emptying process up to the start position illustrated in FIG. 4 a representing a full pumping cycle.
  • the axial movement of the oscillating pump illustrated in FIGS. 4 a - 4 f is illustrated in the graphs of FIGS. 11 and 12 .
  • the cam path has a filling stage PF represented by half of the cam path and an emptying stage PE represented by the other half-section of cam path, the rotor positions shown in FIGS. 4 a to 4 f corresponding to the respective positions A to F indicated on the cam path.
  • the cam slot 38 ′, 38 ′′ may comprise a step down 41 to define a point of no return ensure that the cam finger passes from one cam slot portion 39 a to the next 39 b , preventing the cam finger from returning along the same cam slot.
  • the cam finger 36 is movably mounted to the housing and biased against the rotor by a spring force or a magnetic force so that it tracks the bottom of the cam slot.
  • the change in cam path from portion 39 a to portion 39 b and back to portion to 39 a to commence a new oscillation pump cycle may also be effected without a step in the cam slot by application of an axial biasing force on the rotor at the rotor stop and change of direction positions, the biasing force at one position opposite the biasing force at the other position.
  • the axial biasing force may be effected by an electromagnet or by an alternating spring system between the rotor and housing.
  • Other means to ensure transition of the cam finger in the correct slot portion at the transition position may be employed within the scope of this invention, such as a pivoting or elastic arm in the slot that prevents return of the cam finger and ensures movement in only one sense.
  • the occlusion or leakage detection may be implemented in a variant with a single sided cam (as shown in FIG. 6 ) or a double sided cam with varying cam slot width as shown in FIG. 10 .
  • the axial displacement of the rotor depends on the profile of the cam and the opened and closed positions of the pump inlet and outlet valves V 1 , V 2 as best illustrated in FIG. 9 a where the profile of displacement of the rotor is in the present embodiment split into six sections S 1 , S 2 , S 3 a , S 3 b , S 4 and S 5 .
  • the rotor axial displacement may be detected or measured by a position sensor (not shown) such as a Hall effect sensor or optical sensor on the housing and/or rotor.
  • cam ramp dropdown (CP 4 to CP 5 ) is essentially simultaneous with the valve V 2 opening, occlusion detection is possible, however leakage detection is limited.
  • an axial biasing force is applied on the rotor relative to the housing.
  • the axial biasing force may be applied magnetically and/or by means of a preloaded spring (not shown).
  • the rotor displacement may be detected since the rotor will displace axially in the zone Z 1 before the outlet valve is opened and the ramp S 4 ′ as illustrated in FIG. 9 b may be detected.
  • Leakage in the pump chamber may also be detected by effecting a back and forth displacement of the rotor after the ramp dropdown section CP 4 in the section (zone Z 1 ) where both valves V 1 and V 2 are closed as illustrated in FIG. 9 f .
  • the back and forth rotation of the rotor also named herein “wobbling” while an axial force is applied to the rotor, over an angle of less than 180°, for instance between 10° to 60°, for instance 20° to 30°, causes the rotor shaft to effect an axial displacement S 4 in a leakage condition of greater overall amplitude in the section where the valves are closed, compared to a configuration without wobbling (shown in FIG. 9 b ).
  • the wobbling operation may be performed at the beginning, end or middle of an operation of the pump or even at every cycle of the rotor, depending on the pumping application.
  • the wobbling operation is similar to a unidirectional rotational movement over a large angle (e.g. greater than 180°) to detect small amounts of leakage and a corresponding small axial displacement (e.g., less than 1/10 th of the total stroke). It can however be performed over a smaller angular region where both valves are closed and thus leave more angular space for the other functions, e.g. when open valves are required for intake or expel operations.
  • a back and forth rotation of the rotor while an axial force is applied to the rotor may also be effected to dislodge gas bubbles in the pump chamber, especially during the priming operation.
  • the wobbling is performed at a position where the cam finger is over the ramp section CP 2 , such that the rotor performs a rotational and axial back and forth movement to dislodge bubbles stuck to the pump chamber walls.
  • gas bubbles may be dislodged by rotating the rotor in a reverse direction until the cam finger hits the stop CP 4 to create a mechanical shock (deceleration).
  • a back and forth rotation may be effected two or more times with the housing cam hitting the stop CP 4 at each reverse rotation to create a plurality of successive shocks to dislodge gas bubbles.
  • the rotor may then effect one, two or more turns to evacuate the gas bubbles after the wobbling operation.
  • the bubble dislodging operation may be effected in the priming operation, but may also be effected at any time during the operation of the pump, at regular intervals or for example after a malfunction detection, in particular to distinguish between a malfunction due to leakage or the presence of gas in the pump.
  • a rotor displacement according to FIG. 9 b or 9 f could represent gas in the pump chamber instead of leakage.
  • a bubble dislodging and evacuation operation is effected as described above, and thereafter a further leakage detection operation is effected.
  • the initial malfunction alarm was due to the presence of bubbles, then the bubbles will be evacuated during the bubble dislodging operation and the subsequent leakage detection test will signal normal operation. If the initial alarm was not due to the presence of gas in the pump, then the subsequent test should confirm the leakage malfunction.
  • a 360° cycle double sided cam is illustrated.
  • the slot profile has a section that allows occlusion or leakage detection as described above.
  • the axial displacement during pump filling is defined by the cam section CP 3 .
  • the opposite cam side 40 b engages the cam finger 36 and the axial displacement during pump expelling is thus defined by the position of the cam section CP 5 ′.
  • the cam surfaces CP 3 and CP 5 ′ thus act as reference surfaces that define an accurate amount of pumped liquid at each cycle, without depending on a high biasing force acting on the rotor as in the prior art systems.

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US10272196B2 (en) 2010-09-24 2019-04-30 Perqflo, Llc Infusion pumps
US10967124B2 (en) 2010-11-20 2021-04-06 Medtronic Minimed, Inc. Infusion pumps
US12097353B2 (en) 2010-11-20 2024-09-24 Medtronic Minimed, Inc. Infusion pumps
US10159786B2 (en) 2014-09-30 2018-12-25 Perqflo, Llc Hybrid ambulatory infusion pumps
US12070576B2 (en) 2014-09-30 2024-08-27 Medtronic Minimed, Inc. Hybrid ambulatory infusion pumps
US10946137B2 (en) 2014-09-30 2021-03-16 Medtronic Minimed, Inc. Hybrid ambulatory infusion pumps
US10288050B2 (en) * 2014-12-05 2019-05-14 Boe Technology Group Co., Ltd. Liquid crystal pump and method for ejecting liquid crystal using the same
US20160161773A1 (en) * 2014-12-05 2016-06-09 Beijing Boe Display Technology Co., Ltd. Liquid crystal pump and method for ejecting liquid crystal using the same
US11684712B2 (en) 2015-02-18 2023-06-27 Medtronic Minimed, Inc. Ambulatory infusion pumps and reservoir assemblies for use with same
US10737016B2 (en) 2015-02-18 2020-08-11 Medtronic Minimed, Inc. Ambulatory infusion pumps and reservoir assemblies for use with same
US11672909B2 (en) 2016-02-12 2023-06-13 Medtronic Minimed, Inc. Ambulatory infusion pumps and assemblies for use with same
US11779697B2 (en) 2017-07-07 2023-10-10 Neuroderm, Ltd. Device for subcutaneous delivery of fluid medicament
US10463572B2 (en) 2017-07-07 2019-11-05 Neuroderm, Ltd. Device for subcutaneous delivery of fluid medicament
US10463787B2 (en) 2017-07-07 2019-11-05 Neuroderm, Ltd. Device for subcutaneous delivery of fluid medicament
US10603430B2 (en) 2017-07-07 2020-03-31 Neuroderm, Ltd. Device for subcutaneous delivery of fluid medicament
US11554210B2 (en) 2017-07-07 2023-01-17 Neuroderm, Ltd. Device for subcutaneous delivery of fluid medicament
US11009026B2 (en) * 2017-12-06 2021-05-18 Sensile Medical Ag Micropump
US11022107B2 (en) 2017-12-12 2021-06-01 Sensile Medical Ag Micropump with cam mechanism for axial displacement of rotor
US10954928B2 (en) * 2017-12-20 2021-03-23 Sensile Medical Ag Micropump
US11009018B2 (en) 2017-12-28 2021-05-18 Sensile Medical Ag Micropump
US11980746B2 (en) * 2018-04-19 2024-05-14 Becton, Dickinson And Company Self-pumping syringe
US20190321556A1 (en) * 2018-04-19 2019-10-24 Becton, Dickinson And Company Self-Pumping Syringe
US11174852B2 (en) 2018-07-20 2021-11-16 Becton, Dickinson And Company Reciprocating pump
US12083315B2 (en) 2018-11-30 2024-09-10 Sensile Medical Ag Drug delivery device
US11344669B2 (en) * 2019-08-26 2022-05-31 Eli Lilly And Company Rotary plunger pump subsystems
AU2020340265B2 (en) * 2019-08-26 2023-06-15 Eli Lilly And Company Rotary plunger pump subsystems
US12059549B2 (en) 2021-03-15 2024-08-13 Sensile Medical Ag Drug delivery device
US12115345B2 (en) 2021-03-15 2024-10-15 Sensile Medical Ag Drug delivery device

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US20130017099A1 (en) 2013-01-17
WO2011114285A2 (en) 2011-09-22
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EP2547908A2 (en) 2013-01-23
CN102803725A (zh) 2012-11-28
EP2547908B1 (en) 2019-10-16

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