US7772846B2 - B0 field drift correction in a temperature map generated by magnetic resonance tomography - Google Patents
B0 field drift correction in a temperature map generated by magnetic resonance tomography Download PDFInfo
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- US7772846B2 US7772846B2 US12/249,034 US24903408A US7772846B2 US 7772846 B2 US7772846 B2 US 7772846B2 US 24903408 A US24903408 A US 24903408A US 7772846 B2 US7772846 B2 US 7772846B2
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radiowaves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radiowaves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Detecting, measuring or recording for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
- A61B5/015—By temperature mapping of body part
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/4804—Spatially selective measurement of temperature or pH
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences, Generation or control of pulse sequences ; Operator Console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/565—Correction of image distortions, e.g. due to magnetic field inhomogeneities
- G01R33/56563—Correction of image distortions, e.g. due to magnetic field inhomogeneities caused by a distortion of the main magnetic field B0, e.g. temporal variation of the magnitude or spatial inhomogeneity of B0
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- G—PHYSICS
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- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/58—Calibration of imaging systems, e.g. using test probes, Phantoms; Calibration objects or fiducial markers such as active or passive RF coils surrounding an MR active material
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- G—PHYSICS
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- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/4808—Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
- G01R33/4814—MR combined with ultrasound
Abstract
Description
1. Field of the Invention
This invention concerns a method for correcting a B0 field drift in a temperature map exposure produced by means of magnetic resonance tomography. The invention furthermore concerns a device to implement such a method.
2. Description of the Prior Art
An image representation of an examination subject (in particular of a patient body) that graphically reproduces a spatial distribution of the temperature or of a temperature difference within the examination subject is designated as a temperature map. Such a temperature map can be acquired by magnetic resonance (MR) tomography by interaction of the patient with an MR scanner. The presentation of temperature maps that show the temporal change of the temperature distribution within a patient body is a central component of a successful implementation of a tumor ablation in interventional radiology. In order to kill the tumor tissue, the tumor to be removed is heated non-invasively by the application of focused ultrasound, or by the application of laser light or radio waves by means of a probe inserted into the patient body.
In order to be able to continuously monitor the temperature in the patient body during the intervention, the intervention typically occurs either directly in the MR scanner or in immediate proximity to the same. The temperature monitoring ensues by generating temperature maps of the patient body continuously or at regular intervals over a longer time span, typically of 30 to 120 minutes.
For the non-invasive temperature determination by means of magnetic resonance tomography, use is made of the physical effect that the nuclear magnetic resonance frequency of the hydrogen atoms (protons) in water molecules (in particular in the water molecules of the patient body) exhibits a characteristic temperature dependency. As a result of this temperature dependency, temperature differences in the patient body manifest themselves in a spatial variation of the phase of the magnetic resonance signal (represented in the form of complex numbers). Information about the temperature distribution in the patient body at the point in time of acquisition thus can be acquired from an image known as a phase image that reproduces this phase with spatial resolution. Phase images that were acquired at points in time to be compared are typically subtracted from one another on a pixel-by-pixel or voxel-by-voxel basis to determine the (spatially resolved) temperature difference in the patient body between different acquisition points in time. In interventional radiology, a “heated” phase image—i.e. a phase image acquired at a point in time during the intervention—is subtracted from an “unheated” phase image acquired before beginning the intervention. The temperature difference between the two acquisition points in time is then calculated for each pixel from the resulting difference image.
The precision of a temperature map generated in such a manner, in particular the precision with which the temperature difference between two acquisition points in time can be determined from such a temperature map at a specific location of the patient body, is typically impaired by a phenomenon known as the B0 field drift. This is a slow variation of the basic magnetic field (B0 field) of the MR scanner used to generate the temperature map.
A variation of the B0 field also disadvantageously leads to a change of the proton resonance frequency to which the acquisition of a temperature map is tied (in terms of measurement). Like temperature changes in the patient body, variations of the B0 field thus directly affect the phase images, so temperature-dependent phase changes and B0 field-dependent phase changes cannot be differentiated without further measures. An error in the resulting temperature map that normally grows with increasing distance between the acquisition points in time results due to the B0 drift.
The conventional approach to correct the influence of the B0 field drift in the temperature maps, is to select as correction regions spatial regions of the phase images to be compared in which no temperature change is expected between the acquisition points in time.
For B0 drift correction, the correction regions are calibrated to one another in the phase images to be compared. In other words, a phase image to be compared (normally the phase image acquired later) is corrected such that the correction region of the corrected phase image coincides in terms of the phase values with the correction region of the comparison image.
To achieve such a correction region, for the most part a magnetic resonance phantom filled with water that is placed in the image region of the phase image to be acquired has previously been used. Alternatively, a region of the patient body can also be defined as a correction region in which a heating (or also cooling) between the acquisition points in time can be precluded. The correction regions are in any case to be defined by the user.
Both methods for correcting the influence of the B0 field drift are relatively error-prone. In particular, a displacement of the phantom or—if the correction region was defined in the patient body—a change of the patient position between the acquisition points in time can then lead, as a result of then-incorrect B0 drift correction, to a large error of the resulting temperature map.
An error of the B0 drift correction can additionally result from the fact that nevertheless an unintended temperature change occurs in a correction region between the acquisition points in time. Such errors in particular occur when the correction region was selected in the patient body. The use of a phantom on the one hand often leads to a limited flexibility with regard to the slice selection and/or slice orientation, since the phantom must by necessity be contained in the selected image section.
An object of the invention is to provide a method for correction of a B0 field drift for a temperature map acquisition by means of magnetic resonance tomography, which method is simple to implement and relatively insensitive to errors. A further object of the invention is to provide a device suitable to implement the method.
The above object is achieved according to the invention by a method wherein a magnetic resonance phantom is placed at a stored, marked reference position relative to an acquisition coil of a magnetic resonance tomograph, and a first reference phase image of the phantom is automatically acquired in the acquisition of a first magnetic resonance tomography phase image of an examination subject is based on the stored reference position. Furthermore, a second reference phase image of the phantom is automatically acquired in the acquisition of a later, second phase image, again based on the stored reference position.
To correct a B0 field drift between the acquisition points in time of the first phase image and second phase image, these phase images are adapted to one another according to the requirements of a calibration of the associated reference phase images.
The invention is based on the recognition that the tendency of conventional correction methods toward error is primarily due to the fact that the aforementioned correction regions must be manually selected in the image section of the acquired phase images. Based on this realization is the insight that the tendency of such a correction method toward error can be significantly improved when this selection step is automated in a more reliable manner.
This is achieved by the magnetic resonance phantom being used for correction, the phantom being located outside of the examination subject and thus remains (with good certainty) unaffected by temperature variations in the examination subject. Moreover this automation is achieved by a stored and marked reference position for the phantom being produced that can be located by a device automatically implementing the correction, without requiring interaction with a human user for this purpose.
“Storage” of the reference position means that the location of the reference position is known to a device automatically implementing the method, without human interaction in connection with the method implementation. This storage in particular ensues by storing coordinates that characterize the location of the reference position relative to the acquisition coil in a manner accessible to the device.
In contrast to this, “marking” of the reference position some form of marker that marks the reference position in physical space is provided according to the method. In the simplest case, the maker a rough marking (for example formed by color symbols or the like) that enable a user to place the phantom precisely and reproducibly at the provided reference position. In a refined variant of the method, the marking of the reference position ensues by fixing structure that holds the phantom in the reference position. The fixing structure can be formed by a retainer that holds the phantom relative to the reference position such that the phantom still can be removed. As an alternative, the phantom is permanently fixed in the reference position by a suitable structure.
In a comparably simple embodiment of the invention, the acquisition coil relative to which the reference position is defined is the image acquisition coil that is provided to acquire the raw data of the examination subject. In this case, both the phase images of the examination subject and the respective reference phase images of the phantom are generated from raw data of one and the same acquisition coil. In an alternative embodiment of the invention, different acquisition coils—namely an image acquisition coil and a reference acquisition coil separate from this—are provided to acquire the phase images of the examination subject and to acquire the reference phase images of the phantom. In this case, the reference position of the phantom is defined relative to the reference coil. The acquisition coil associated with the phantom, in particular the possibly provided reference acquisition coil, is also used as a transmission coil, i.e. also used to excite the hydrogen atoms of the phantom.
The differentiated embodiment of the invention with two separate acquisition coils to acquire the phase images of the examination subject, or to acquire the reference phase images of the phantom in particular, has the advantage that the phantom for acquisition of the reference phase images can be placed in the MR scanner independent of the image acquisition coil. When the reference acquisition coil is also used as a transmission coil, the phantom and the reference acquisition coil can be arranged at an arbitrary location within the measurement region (field of view—FOV) of the magnetic resonance scanner. Given the use of a separate reference acquisition coil, it is not necessary to conduct a location selection in the acquisition of the reference phase images by the application of a suitable magnetic gradient field. Therefore, only very little measurement time is required for the acquisition of a reference phase image. The correction method thus can be implemented with a time saving.
Particularly with a shared acquisition coil for acquisition of phase images and reference phase images, the phantom is advantageously fashioned annularly, with the diameter of the phantom being advantageously adapted to the diameter of the acquisition coil. Such a phantom can be arranged particularly well in the acquisition region of the acquisition coil without hindering the positioning of the acquisition coil with regard to the patient.
The reference position is preferably defined such that the phantom is arranged directly at (i.e. in immediate proximity to) the acquisition coil.
In a further embodiment of the invention, containers filled with fat and/or oil are used as a phantom. The physical effect observed to detect the temperature change, namely the shift of the proton resonance frequency, visibly occurs only with water molecules. In contrast, temperature changes in fat or oil have no significant effect on the phase images. Given use of a fat/oil phantom, a precise correction of the B0 field drift is therefore possible even for the case that the temperature of the phantom changes between the acquisition points in time. The use of a fat/oil phantom for B0 drift correction is therefore inventive by itself.
The device according to the invention has a marker for marking a reference position for a magnetic resonance phantom relative to an acquisition coil. The device furthermore has a control unit that is fashioned to automatically prompt the acquisition of an associated reference phase image of the phantom given the acquisition of a phase image of an examination subject. The device also has a correction unit that is fashioned to adapt two phase images acquired at different times to one another according to the requirements of a calibration of two reference phase images respectively associated with the phase images.
In the simplest embodiment, the device is provided as a retrofit package for an existing conventional magnetic resonance tomography apparatus, and in this embodiment has only those items that are not already components of the magnetic resonance tomography apparatus. For example, the device to implement the method can normally resort to the acquisition coil of the magnetic resonance scanner that is conventionally present already, as long as placement of the phantom (possibly also already present) in the defined reference position relative to the acquisition coil is achieved by the marker. The acquisition coil and the phantom are therefore not necessarily components of the correction device. Nevertheless, a special acquisition coil and/or a special phantom could naturally be provided as additional components of the correction device. In the case of a retrofit package, the control unit and/or the correction unit preferably are software modules that modify, replace or supplement the conventional control software of the magnetic resonance tomography apparatus, in particular in the context of software update or plug-in.
As an alternative, the device according to the invention can already be integrated into a magnetic resonance tomography apparatus or its components (for example a head coil or breast coil).
If, as described above, the device includes a separate reference acquisition coil for acquisition of raw data for reference phase images, this reference acquisition coil is preferably combined with an image acquisition coil into a permanently connected module. In addition or as an alternative, the phantom is integrated with the associated acquisition coil (i.e. with the reference acquisition coil, in the event that one is present) or otherwise with the image acquisition coil into a permanently connected module. The integral combination of the phantom with the image acquisition coil, or the reference acquisition coil, is particularly user-friendly since the user does not necessarily have to come into contact with the B0 drift correction. This design of the device therefore also enables a particularly foolproof implementation of the correction method.
The magnetic resonance tomography apparatus 1 shown in
The scanner 2 contains (is not shown) magnetic coils with which a basic magnetic field B0 aligned parallel to a tunnel axis 6 is generated in the tunnel 3. The direction predetermined by the tunnel axis 6 is subsequently also designated as the z-direction (
The scanner 2 furthermore contains gradient coils by means of which one or more magnetic gradient fields can be superimposed on the constant basic magnetic field B0. The magnetic field strength of each gradient field decreases or increases in a defined manner in the z-direction and/or perpendicular thereto (x-direction, y-direction). A specific spatial region within the patient body 4 is able to be selected by means of these gradient fields.
The scanner 2 also has a transmission coil 7 (
The excitation of the hydrogen nuclei results in a fluctuating magnetization that can be measured in the form of an electrical signal by means of an (image) acquisition coil 8. Raw data R are derived from this signal.
A tomogram T, i.e. a three-dimensional image of the patient body 4 or of a part of said patient body 4, is derived from the raw data R by numerical-mathematical calculation by evaluation logic of the magnetic resonance tomography apparatus 1 that is implemented in a computerized control and evaluation system 9. The tomogram T can be presented on a monitor 10 of the magnetic resonance tomography apparatus 1 (for example in the form of two-dimensional slices).
The magnetic resonance tomography apparatus 1 also has typical input means (such as keyboard, mouse etc.) for control.
For the image data acquisition, the gradient coil and the transmission coil 7 of the magnetic resonance tomography apparatus 1 are suitably controlled by a control program implemented in the control and evaluation system 9 so that various spatial regions of the patient body 4 are selectively chosen and excited in the manner of a grid. The respectively generated magnetization is read out via the acquisition coil 8.
As described above, the generation of a temperature map TK of the patient body 4 is based on the acquisition of phase images P of the patient body 4. Such a phase image P contains the phase of the aliased magnetic resonance signal that is present with spatial resolution in the form of complex numbers. The magnetic resonance tomography apparatus 1 a phase image generation unit 11 (
The generate a temperature map TK from the phase images P of the patient body 4, the magnetic resonance tomography apparatus 1 furthermore has a temperature map generation unit 12 (
In addition to the components described above, the magnetic resonance tomography apparatus 1 according to
The control unit 21 is a software module that represents a component of the control program implemented in the control and evaluation system 9. The control unit 21 hereby suitably controls the transmission coil 7, the phase image generation unit 11, the correction unit 22, the temperature map generation unit 12 and, if applicable, the gradient coil, and thus effects the automatic implementation of the method described in detail below.
The correction unit 22 is an additional software module that forms a component of the evaluation logic of the control and evaluation system 9. The correction unit 22 implements the calculations required for the correction method (described in detail in the following) on the basis of the phase images P supplied by the phase image generation unit 11.
The magnetic resonance phantom 23 is a container (merely shown here as an example in the shape of a cube) that is filled with a fat or an oil.
The mount 24 is fashioned such that it permanently or removable holds the phantom 23 in a defined reference position r relative to the acquisition coil 8. The coordinates of the reference position r are stored in the control unit 21.
To acquire the temperature map TK (
The control unit 21 subsequently initiates the acquisition of a first phase image P1 of a region 25 of the patient body 4 to be acquired (
In order to enable the correction of the B0 field drift, the control unit 21 initiates the acquisition of an associated reference phase image RP1 (
In the embodiment of the device 20 according to
At a later point in time t1, a second phase image P2 of the same selected region 25 of the patient body 4 is generated analogous to the generation of the phase image P1, and a second reference phase image RP2 of the phantom 23 is generated analogous to the generation of the reference phase image RP1.
As schematically shown in
In the scheme according to
As can be seen from
Analogous to the reference phase image RP2, i.e. in the same manner, the phase values of the phase image P2 are also modified by the correction unit 22, whereby the phase difference of the phase images P1 and P2 that is caused by the B0 field drift is compensated (indicated by arrow 28 b in
The result of this B0 drift correction is shown in
For this purpose, in a final method step according to
In the embodiment according to
According to
According to
Deviating from the embodiments of the invention described in connection with
Although modifications and changes may be suggested by those skilled in the art, it is the intention of the inventor to embody within the patent warranted hereon all changes and modifications as reasonably and properly come within the scope of his contribution to the art.
Claims (19)
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DE200710048970 DE102007048970A1 (en) | 2007-10-12 | 2007-10-12 | B0 field drift correction in a magnetic resonance tomographic temperature chart |
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US20090238429A1 (en) * | 2008-03-19 | 2009-09-24 | Joerg Roland | Magnetic resonance tomography method and apparatus for correcting drift of the b0 field in a temperature map |
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