US7447542B2 - Three-dimensional monitoring of myographic activity - Google Patents

Three-dimensional monitoring of myographic activity Download PDF

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Publication number
US7447542B2
US7447542B2 US10/616,995 US61699503A US7447542B2 US 7447542 B2 US7447542 B2 US 7447542B2 US 61699503 A US61699503 A US 61699503A US 7447542 B2 US7447542 B2 US 7447542B2
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Prior art keywords
emg
sensor
processor
activity
ctg
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Expired - Fee Related, expires
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US10/616,995
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English (en)
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US20050010127A1 (en
Inventor
Ilan Calderon
Gal Ben-David
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OBSTETRICIAN TOOLS Ltd
OB Tools Ltd
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OB Tools Ltd
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Assigned to OBSTETRICIAN TOOLS LTD. reassignment OBSTETRICIAN TOOLS LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BEN-DAVID, GAL, CALDERON, ILAN
Priority to US10/616,995 priority Critical patent/US7447542B2/en
Priority to AT04744961T priority patent/ATE424759T1/de
Priority to PCT/IL2004/000621 priority patent/WO2005004717A1/en
Priority to DE602004019924T priority patent/DE602004019924D1/de
Priority to ES04744961T priority patent/ES2323960T3/es
Priority to EP04744961A priority patent/EP1643900B1/de
Priority to CA2531650A priority patent/CA2531650C/en
Publication of US20050010127A1 publication Critical patent/US20050010127A1/en
Priority to US12/264,293 priority patent/US8682423B2/en
Publication of US7447542B2 publication Critical patent/US7447542B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/389—Electromyography [EMG]
    • A61B5/391—Electromyography [EMG] of genito-urinary organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4343—Pregnancy and labour monitoring, e.g. for labour onset detection
    • A61B5/4356—Assessing uterine contractions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
    • A61B5/283—Invasive
    • A61B5/288—Invasive for foetal cardiography, e.g. scalp electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A61B5/344—Foetal cardiography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/02—Measuring pulse or heart rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0866—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving foetal diagnosis; pre-natal or peri-natal diagnosis of the baby

Definitions

  • the present invention relates generally to three-dimensional monitoring (e.g., measuring, imaging and displaying) of myographic activity, such as that of the uterus.
  • a normal uterus does not contract vigorously throughout most of pregnancy and thus provides a tranquil environment for the growing fetus.
  • the myometrium muscle tissue of the uterus
  • Contractions of the uterus are directly proportional to the underlying electrical activity of the muscle.
  • the frequency, duration and magnitude of a uterine contraction are directly proportional respectively to the frequency, duration and propagation of action potentials in the myometrium and other muscle cells associated with movement of the uterus.
  • the present invention seeks to provide an improved system for three-dimensional monitoring (e.g., measuring, imaging and displaying) of myographic activity, e.g., uterine activity, as is described in detail hereinbelow.
  • myographic activity e.g., uterine activity
  • the invention is described as applied to uterine activity, but the invention is not limited to uterine muscular activity and may be applied to other muscles as well.
  • the invention may process electromyograms (EMG), position sensing signals and cardiotocograms (CTG) to form 3D images of muscle contraction, in particular uterine myographic activity.
  • EMG electromyograms
  • CCG cardiotocograms
  • the invention may have many applications, such as but not limited to, prevention of premature birth, measuring and monitoring effectiveness of labor contractions, and research in obstetrics and gynecology.
  • a system comprising an electromyogram (EMG) system operative to sense electromyographic activity generated in a muscle, at least one position sensor, and a processor in communication with the EMG system and the at least one position sensor, the processor operative to process data of the EMG system and three-dimensional position and orientation information from the at least one position sensor to provide an output that comprises electromyographic activity data as a function of the three-dimensional position and orientation of the at least one position sensor.
  • EMG electromyogram
  • the EMG system comprises at least one EMG sensor adapted to sense electromyographic activity generated in a muscle of interest and at least one reference EMG sensor adapted to sense electromyographic activity generated in a reference muscle.
  • a monitor may be coupled to the processor, adapted to display processed information from the processor.
  • a position sensing system is adapted to measure the three-dimensional position and orientation of the at least one position sensor with respect to a reference position fixed in space.
  • a cardiotocogram (CTG) monitor is in communication with the processor, the CTG monitor comprising a fetal beat-to-beat heart rate (FHR) sensor and a uterine labor activity (TOCO) sensor.
  • FHR fetal beat-to-beat heart rate
  • TOCO uterine labor activity
  • the processor is operative to process data from the CTG monitor in addition to the data of the EMG system and the three-dimensional position information from the at least one position sensor to provide an output that comprises electromyographic activity data and CTG data as a function of the three-dimensional position of the at least one position sensor.
  • a warning device is in communication with the processor, operative to issue a warning if processed data processed by the processor is above a predefined limit.
  • FIG. 1 is a simplified pictorial illustration of a system for three-dimensional monitoring of myographic activity, constructed and operative in accordance with an embodiment of the present invention.
  • FIG. 2 is a display of an electromyogram (EMG) and cardiotocogram (CTG) displayed with a 3D image of muscle contraction as sensed by a position sensing system, in accordance with an embodiment of the present invention.
  • EMG electromyogram
  • CCG cardiotocogram
  • FIG. 1 illustrates a system 10 for three-dimensional monitoring of myographic activity, constructed and operative in accordance with an embodiment of the present invention.
  • System 10 may comprise a CTG monitor 12 .
  • CTG monitor 12 may sense medical parameters that are important to assess the condition of a fetus, namely, fetal beat-to-beat heart rate (FHR) and uterine (or labor) activity (called TOCO), among others. Assessment of the FHR and TOCO may enable determination of the fetal condition.
  • FHR fetal beat-to-beat heart rate
  • TOCO uterine activity
  • CTG monitor 12 may comprise an FHR sensor 14 and a TOCO sensor 16 .
  • the FHR may be measured directly and internally, wherein FHR sensor 14 comprises a fetal scalp electrode applied to the fetal skin.
  • the FHR may be measured indirectly by ultrasound, e.g., by listening to the fetal heart sound or by measuring the Doppler shift of an ultrasound wave reflected by the moving parts of the fetal heart, particularly the heart walls and/or the heart valves.
  • the FHR may be recorded by an abdominal electrocardiogram, by means of electrocardiogram electrodes or an ultrasound transducer placed on the abdomen of the mother.
  • TOCO sensor 16 may comprise a toco transducer (tocodynamometer), for example, placed externally on the fundus uteri of the mother, such as about centrally on the abdomen.
  • a toco transducer may be a tension-measuring device, most commonly employing one or more resistive wire strains.
  • an intravaginal or intrauterine toco transducer may be used, which may comprise a hose connected with a direct pressure transducer and introduced into the uterus.
  • a non-limiting example of a suitable CTG monitor 12 is the “HP Series 50 XM Fetal/Maternal Monitor”, commercially available from Hewlett-Packard. It monitors maternal blood pressure non-invasively, pulse oximetry, pulse rate and maternal ECG.
  • the present invention is not limited by any particular technique or apparatus for sensing the FHR and TOCO.
  • CTG monitor 12 may be in communication with a processor 18 , such as but not limited to, by means of an RS232 connection.
  • Processor 18 may comprise, without limitation, a personal computer (PC), a dedicated processor chip or a remote processor on some website.
  • a monitor 20 may be coupled to processor 18 for displaying processed information and images.
  • System 10 may comprise a position sensing system 22 that senses the three-dimensional position and orientation of one or more position sensors 24 affixed on the mother's body or the fetus.
  • a non-limiting example of a suitable position sensing system 22 is the “PCI bird” model, commercially available from Ascension Technology Corporation, PO Box 527, Burlington, Vt. 05402, USA.
  • the “PCI bird” measures the position and orientation of one or more receiving antenna sensors 24 with respect to a transmitting antenna 26 fixed in space.
  • the transmitting antenna 26 may be driven by a pulsed DC signal, for example.
  • the receiving antenna (position sensor) 24 may measure not only the transmitted magnetic field pulse but also the earth's magnetic field.
  • Either processor 18 or a dedicated processor in position sensing system 22 may control and coordinate operation of the receiving antenna (position sensor) 24 and transmitting antenna 26 , and process the signals into position and orientation outputs.
  • System 10 may comprise an EMG system 28 that senses electrical activity generated in a muscle, that is, electromyographic activity (e.g., electromyometrial activity of the uterine muscles).
  • the electrical muscular activity may be sensed or monitored by one or more EMG sensors 30 , which may comprise, without limitation, surface and/or needle recording electrodes.
  • EMG system 28 may comprise, without limitation, an analog front end unit 32 in communication with an analog data acquisition unit 34 .
  • EMG system 28 is preferably in communication with processor 18 .
  • the EMG sensors 30 Prior to measuring the electromyographic activity, the EMG sensors 30 may be affixed to the mother's body.
  • a reference EMG sensor 36 e.g., reference voltage electrode
  • the other EMG sensors 30 may be affixed to different points on and/or around the uterus.
  • the position sensors 24 may be placed near the EMG sensors 30 and 36 , such that position sensing system 22 may measure the three-dimensional position of EMG sensors 30 and 36 .
  • Processor 18 may then process the electrical muscular activity signals (designated by reference numeral 42 in FIG. 2 ) as a function of their three-dimensional positions (designated by reference numeral 44 in FIG. 2 ) and as a function of the CTG monitor 12 readings (designated by reference numeral 46 in FIG. 2 ) at the same time.
  • the processed information may be displayed on monitor 20 .
  • System 10 may comprise a warning device 38 in communication with processor 18 that issues a warning (e.g., visual or audible) if the processed data processed by processor 18 is above a predefined limit. For example, system 10 may warn if the three-dimensional position of the EMG sensors 30 together with the TOCO information indicate the onset of premature birth. As another example, system 10 may warn if the three-dimensional position of the EMG sensors 30 together with the FHR and TOCO information indicate the fetus being in distress.
  • a warning e.g., visual or audible
  • FIG. 2 illustrates an example of a display of an EMG and CTG (FHR and TOCO) displayed with a 3D image of muscle cantraction as sensed by position sensing system 22 , in accordance with an embodiment of the present invention.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Burglar Alarm Systems (AREA)
US10/616,995 2003-07-11 2003-07-11 Three-dimensional monitoring of myographic activity Expired - Fee Related US7447542B2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US10/616,995 US7447542B2 (en) 2003-07-11 2003-07-11 Three-dimensional monitoring of myographic activity
ES04744961T ES2323960T3 (es) 2003-07-11 2004-07-11 Monitorizacion tridimensional de la actividad miografica.
PCT/IL2004/000621 WO2005004717A1 (en) 2003-07-11 2004-07-11 Three-dimensional monitoring of myographic activity
DE602004019924T DE602004019924D1 (de) 2003-07-11 2004-07-11 Dreidimensionale überwachung der myographischen aktivität
AT04744961T ATE424759T1 (de) 2003-07-11 2004-07-11 Dreidimensionale überwachung der myographischen aktivität
EP04744961A EP1643900B1 (de) 2003-07-11 2004-07-11 Dreidimensionale überwachung der myographischen aktivität
CA2531650A CA2531650C (en) 2003-07-11 2004-07-11 Three-dimensional monitoring of myographic activity
US12/264,293 US8682423B2 (en) 2003-07-11 2008-11-04 Three-dimensional monitoring of myographic activity

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Application Number Priority Date Filing Date Title
US10/616,995 US7447542B2 (en) 2003-07-11 2003-07-11 Three-dimensional monitoring of myographic activity

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US12/264,293 Continuation-In-Part US8682423B2 (en) 2003-07-11 2008-11-04 Three-dimensional monitoring of myographic activity

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US20050010127A1 US20050010127A1 (en) 2005-01-13
US7447542B2 true US7447542B2 (en) 2008-11-04

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US (1) US7447542B2 (de)
EP (1) EP1643900B1 (de)
AT (1) ATE424759T1 (de)
CA (1) CA2531650C (de)
DE (1) DE602004019924D1 (de)
ES (1) ES2323960T3 (de)
WO (1) WO2005004717A1 (de)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080167553A1 (en) * 2003-08-06 2008-07-10 Yoav Paltieli Method and Apparatus For Monitoring Labor Parameter
US20080275316A1 (en) * 2007-05-04 2008-11-06 Reproductive Research Technologies, Lp Skin impedance matching system and method for skin/electrode interface
US20090062683A1 (en) * 2003-07-11 2009-03-05 Ilan Calderon Three-dimensional monitoring of myographic activity
US20110190652A1 (en) * 2010-01-29 2011-08-04 Reproductive Research Technologies, Llp System and method for acquiring and displaying uterine emg signals
US20110237972A1 (en) * 2010-03-23 2011-09-29 Robert Garfield Noninvasive measurement of uterine emg propagation and power spectrum frequency to predict true preterm labor and delivery
WO2012106219A1 (en) 2011-01-31 2012-08-09 Obt Ltd. Monitoring of uterine contraction intensity and fetal heart rate
US8386026B2 (en) * 2010-04-12 2013-02-26 Reproductive Research Technologies, L.P. System and method for acquiring and displaying abdominal EMG signals
WO2014008224A1 (en) 2012-07-03 2014-01-09 Ob Tools Ltd. Regulating uterine muscular activity
WO2016189479A1 (en) 2015-05-27 2016-12-01 Ob Tools Ltd. Vaginal speculum with electromyographic sensors
US9585583B1 (en) 2014-03-04 2017-03-07 Mortara Instrument, Inc. Myogram determination from ECG signal

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ITFI20030298A1 (it) * 2003-11-25 2005-05-26 Pierfrancesco Belli Apparecchiatura automatica per la gestione del travaglio di parto.
TWI266217B (en) * 2004-12-28 2006-11-11 Ind Tech Res Inst Methods and devices of a multi-functional operating interface for a nursing machine
US8447704B2 (en) 2008-06-26 2013-05-21 Microsoft Corporation Recognizing gestures from forearm EMG signals
US9037530B2 (en) 2008-06-26 2015-05-19 Microsoft Technology Licensing, Llc Wearable electromyography-based human-computer interface

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US5373852A (en) * 1993-06-25 1994-12-20 The Regents Of The University Of California Monitoring uterine contractions by radiotelemetric transmission
US5747996A (en) * 1994-03-09 1998-05-05 U.S. Philips Corporation Device for determining the spatial position of a sensor element which is displacement relative to a reference element
US5991701A (en) * 1997-10-13 1999-11-23 Kinex Iha Corp. Method for improved instantaneous helical axis determination
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Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090062683A1 (en) * 2003-07-11 2009-03-05 Ilan Calderon Three-dimensional monitoring of myographic activity
US8682423B2 (en) * 2003-07-11 2014-03-25 Ob Tools Ltd. Three-dimensional monitoring of myographic activity
US7850625B2 (en) * 2003-08-06 2010-12-14 Trig Medical Ltd. Method and apparatus for monitoring labor parameter
US20080167553A1 (en) * 2003-08-06 2008-07-10 Yoav Paltieli Method and Apparatus For Monitoring Labor Parameter
US8444559B2 (en) 2007-05-04 2013-05-21 Reproductive Research Technologies, Lp Skin impedance matching system and method for skin/electrode interface
US20080275316A1 (en) * 2007-05-04 2008-11-06 Reproductive Research Technologies, Lp Skin impedance matching system and method for skin/electrode interface
US20110190652A1 (en) * 2010-01-29 2011-08-04 Reproductive Research Technologies, Llp System and method for acquiring and displaying uterine emg signals
US20110237972A1 (en) * 2010-03-23 2011-09-29 Robert Garfield Noninvasive measurement of uterine emg propagation and power spectrum frequency to predict true preterm labor and delivery
US8386026B2 (en) * 2010-04-12 2013-02-26 Reproductive Research Technologies, L.P. System and method for acquiring and displaying abdominal EMG signals
WO2012106219A1 (en) 2011-01-31 2012-08-09 Obt Ltd. Monitoring of uterine contraction intensity and fetal heart rate
WO2014008224A1 (en) 2012-07-03 2014-01-09 Ob Tools Ltd. Regulating uterine muscular activity
US8731651B2 (en) * 2012-07-03 2014-05-20 Ob Tools Ltd. Regulating uterine muscular activity
US9585583B1 (en) 2014-03-04 2017-03-07 Mortara Instrument, Inc. Myogram determination from ECG signal
US10722135B2 (en) 2014-03-04 2020-07-28 Welch Allyn, Inc. Myogram determination from ECG signal
WO2016189479A1 (en) 2015-05-27 2016-12-01 Ob Tools Ltd. Vaginal speculum with electromyographic sensors
DE212016000102U1 (de) 2015-05-27 2018-01-10 Ob Tools Ltd. Vaginalspekulum mit elektromyographischen Sensoren
US10966601B2 (en) * 2015-05-27 2021-04-06 Ob Tools Ltd. Vaginal speculum with electromyographic sensors

Also Published As

Publication number Publication date
ES2323960T3 (es) 2009-07-28
DE602004019924D1 (de) 2009-04-23
CA2531650C (en) 2012-04-24
EP1643900B1 (de) 2009-03-11
CA2531650A1 (en) 2005-01-20
EP1643900A1 (de) 2006-04-12
US20050010127A1 (en) 2005-01-13
WO2005004717A1 (en) 2005-01-20
ATE424759T1 (de) 2009-03-15

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Owner name: OBSTETRICIAN TOOLS LTD., ISRAEL

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