US6517768B1 - Hermetically sealed container including a nozzle with a sealing bead - Google Patents

Hermetically sealed container including a nozzle with a sealing bead Download PDF

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Publication number
US6517768B1
US6517768B1 US09/569,274 US56927400A US6517768B1 US 6517768 B1 US6517768 B1 US 6517768B1 US 56927400 A US56927400 A US 56927400A US 6517768 B1 US6517768 B1 US 6517768B1
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United States
Prior art keywords
nozzle
bead
groove
molds
seal
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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US09/569,274
Inventor
Gerhard H. Weiler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Automatic Liquid Packaging Inc
Catalent Pharma Solutions LLC
Catalent Pharma Solutions Inc
Catalent USA Woodstock Inc
Catalent USA Paintball Inc
Catalent USA Packaging LLC
Original Assignee
Automatic Liquid Packaging Inc
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Filing date
Publication date
Family has litigation
Priority to US09/084,804 priority Critical patent/US6068148A/en
Application filed by Automatic Liquid Packaging Inc filed Critical Automatic Liquid Packaging Inc
Priority to US09/569,274 priority patent/US6517768B1/en
Application granted granted Critical
Publication of US6517768B1 publication Critical patent/US6517768B1/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22187309&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US6517768(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Assigned to MORGAN STANLEY SENIOR FUNDING, INC. reassignment MORGAN STANLEY SENIOR FUNDING, INC. SECURITY AGREEMENT Assignors: CARDINAL HEALTH 400, INC., CARDINAL HEALTH 406, LLC, CARDINAL HEALTH 409, INC., CARDINAL HEALTH 421, INC., CARDINAL HEALTH PTS, LLC, GLACIER CORPORATION, PTS ACQUISITION CORP., PTS INTERMEDIATE HOLDINGS LLC, R.P. SCHERER TECHNOLOGIES, INC.
Assigned to CATALENT USA WOODSTOCK, INC., CATALENT USA PACKAGING, LLC, CATALENT PHARMA SOLUTIONS, INC., CATALENT PHARMA SOLUTIONS, LLC, CATALENT USA PAINTBALL, INC. reassignment CATALENT USA WOODSTOCK, INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: CARDINAL HEALTH 400, INC., CARDINAL HEALTH 406, LLC, CARDINAL HEALTH 409, INC., CARDINAL HEALTH 421, INC., CARDINAL HEALTH PTS, LLC
Anticipated expiration legal-status Critical
Application status is Expired - Fee Related legal-status Critical

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/02Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0223Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
    • B65D1/023Neck construction
    • B65D1/0238Integral frangible closures
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06Ampoules or carpules
    • A61J1/067Flexible ampoules, the contents of which are expelled by squeezing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048Connecting means
    • A61J1/2055Connecting means having gripping means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096Combination of a vial and a syringe for transferring or mixing their contents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00Bottles and jars
    • Y10S215/03Medical
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S604/00Surgery
    • Y10S604/905Aseptic connectors or couplings, e.g. frangible, piercable

Abstract

A hermetically sealed, molded thermoplastic dispensing container is provided which includes a nozzle having a resilient and unitary annular bead about the periphery thereof. The nozzle is sized to receive the hub of a dispensing assembly in a mating relationship and the bead provides a secure friction fit and liquid seal between the hub and the nozzle. The method of forming a container with a nozzle having such a bead includes the use of seal molds having a groove conforming to the shape of the bead and a vacuum passage in communication with such groove and the step of creating a vacuum through the passage and the groove to pull a portion of a parison into the groove to form the bead.

Description

This application is a division of application Ser. No. 09/084,804, filed May 26, 1998 now U.S. Pat. No. 6,068,148.

FIELD OF THE INVENTION

This invention relates to hermetically sealed containers and, more particularly, to a dispensing container with a nozzle that includes a sealing bead.

BACKGROUND OF THE INVENTION

Hermetically sealed containers with luer tapered dispensing nozzles adapted to receive the hub of a hyperdermic needle assembly are known in the art. See, for example, FIG. 11 of U.S. Pat. No. 5,595,314 to Weiler which discloses a male luer connector adapted to receive the female hub of a hyperdermic needle. Internal threads in the connector engage lugs on the hub of the needle for securing the needle to the nozzle.

Although the connector shown in U.S. Pat. No. 5,595,314 has proven useful, a separate insert is required to provide the connector feature.

Hermetically sealed containers produced by the so-called blow/fill/seal techniques such as, for example, the blow/fill/seal techniques shown and disclosed in U.S. Pat. No. 4,671,763 to Weiler have gained widespread acceptance in the pharmaceutical field. Such containers are formed between cooperating molds that are closed around an extended length of a parison. This fabrication process, while efficient, necessarily results in a finished container with a mold seam or parting line.

The presence of such a seam on a dispensing nozzle is disadvantageous in applications where it is desired to mount a dispensing needle or spike on the nozzle because the seam may create a gap between mating surfaces through which liquid contents of the container can leak during the dispensing operation. It would thus also be desirable to provide a container with an improved nozzle that provides a liquid seal in the region of the mold seam. The present invention provides such an improved nozzle on a dispensing container.

SUMMARY OF THE INVENTION

A hermetically sealed, molded thermoplastic dispensing container embodying the present invention includes a nozzle unitary with the container, which nozzle defines a dispensing aperture. A removable closure unitary with the nozzle occludes the aperture, and a resilient annular bead about the periphery of the nozzle, unitary therewith and spaced from the aperture, provides a liquid seal for a dispensing needle or spike mounted thereto.

The nozzle is sized to receive a hub of a dispensing assembly such as, for example, a hypodermic needle assembly, in a mating relationship therewith. The annular bead provides a liquid seal between the hub and the nozzle.

In one embodiment of the present invention, the resilient bead has substantially a fin-like or triangular cross-section and includes spaced-apart upper and lower surfaces which extend radially outwardly from the outer surface of the nozzle at an obtuse angle and converge to an edge.

In one embodiment, the obtuse angle between the outer surface of the nozzle and the upper surface of the bead is approximately 120 degrees while the obtuse angle between the outer surface of the nozzle and the lower surface of the bead is approximately 135 degrees.

Other suitable bead embodiments are, for example, a bead where the lower surface of the bead extends radially outwardly from the outer surface of the nozzle substantially normal to the nozzle surface and the upper surface of the bead extends radially outwardly from the outer surface of the nozzle at an obtuse angle. The present invention also contemplates embodiments where the bead is syncline or rounded.

A container including the present features can be made by a method which includes the steps of extending a parison segment between main molds and seal molds, respectively, where the seal molds include a groove conforming to the shape of the bead and a vacuum passage which extends from the groove through the seal molds and closing the main molds to form a body portion of the container and then filling the body portion with a liquid. Next, the seal molds are closed to form the nozzle and seal the container. A vacuum is created through the passage and the groove in the seal molds to pull a portion of the parison into the groove and form the bead during the sealing operation.

Numerous other advantages and features of the present invention will become readily apparent from the following detailed description of the invention, from the claims, and from the accompanying drawings.

BRIEF DESCRIPTION OF THE DRAWINGS

In the accompanying drawings forming part of the specification, in which like numerals are employed to designate like parts throughout the same,

FIG. 1 is a perspective view of one embodiment of a container of the present invention in its blow molded, filled and sealed configuration;

FIG. 2 is an enlarged fragmentary part sectional view of the nozzle and cap portion of the container of FIG. 1 in elevation;

FIG. 3 is an enlarged fragmentary part sectional view of another nozzle embodiment in elevation;

FIG. 4 is an enlarged fragmentary part sectional view of another nozzle embodiment in elevation;

FIG. 5 is an enlarged fragmentary part sectional view of the container of FIG. 1 in elevation with the cap removed therefrom and a dispensing needle fitted over the nozzle;

FIG. 6 is a fragmentary elevational view, partly in section, of the molds for forming the container of FIG. 1, the main molds being shown in their closed position for forming the container body portion and the seal molds in their open position;

FIG. 7 is a fragmentary elevational view, partly in section, similar to that of FIG. 6 but showing the seal molds closed for forming the neck, nozzle and cap portions of the container; and

FIG. 8 is a fragmentary elevational view, partly in section, similar to FIG. 7 but additionally showing the parison in the groove in the seal molds for forming the bead on the nozzle.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

Referring to FIGS. 1 and 2, a hermetically sealed, molded thermoplastic container 10 embodying the present invention includes a body portion 12, a neck portion 14 unitary with the body portion 12, a unitary stem or nozzle 16 extending in a direction away from the neck portion 14 and including an upper end defining a dispensing or draining aperture 18, and a removable twist-off overcap or closure 20 which occludes the aperture 18 and is unitary with the nozzle 16. The closure 20 is delineated by a frangible web 22.

Because the container 10 is fabricated by the so-called blow/fill/seal techniques such as, for example, the techniques shown and disclosed in U.S. Pat. No. 4,671,763 to Weiler which includes the use of cooperating molds, the container 10 includes a central peripheral mold seam or parting line 23.

The molded thermoplastic material can be a conventional molding material such as high density polyethylene, low density polyethylene, polypropylene, and the like, compatible with the contemplated container contents. Containers embodying the present invention can have a wide variety of shapes and capacities.

The invention disclosed herein is, of course, susceptible of embodiment in many different forms. Shown in the drawings and described hereinbelow in detail are preferred embodiments of the invention. It is to be understood, however, that the present disclosure is an exemplification of the principles of the invention and does not limit the invention to the illustrated embodiments.

For ease of description, the container 10 embodying the present invention is described hereinbelow in its usual assembled positions as shown in the accompanying drawings and terms such as upper, lower, horizontal, etc., will be used herein with reference to this usual position. However, the container may be manufactured, stored, transported, sold, or used in orientations other than those described and shown herein.

As shown in FIGS. 1 and 2, the nozzle 16 includes an outer peripheral surface 24 and a resilient, unitary annular bead 26 extending circumferentially and radially outwardly about the outer peripheral surface 24. The bead 26 is spaced from, and lies in a plane generally parallel to, the aperture 18 of the nozzle 16.

In the preferred embodiment of the present invention, the bead 26 has a substantially triangular or fin-shaped cross-section and includes spaced-apart lower and upper flat surfaces 28 and 30 respectively which converge radially outwardly at an obtuse angle from the nozzle outer surface 24 and include distal ends which terminate into an annular edge or tip 32. Particularly, the lower surface 28 extends unitarily outwardly from the outer nozzle surface 24 at an obtuse angle which is greater than the obtuse angle between the upper surface 30 and the outer nozzle surface 24. Preferably, the lower surface 28 extends away from the outer nozzle surface 24 at an angle A which is approximately 135 degrees while the upper surface 30 extends away from the outer nozzle surface 24 at an angle B which is approximately 120 degrees.

The present invention is not limited to the particular triangular orientation of FIG. 2, of course, but rather encompasses all other suitable and desirable configurations such as, for example, a syncline configuration or the embodiment of FIG. 3 which shows a nozzle 116 including an outer nozzle surface 124 having a substantially triangularly shaped annular bead 126 extending circumferentially and radially outwardly therefrom. The bead 126 includes a lower flat surface 128 which extends unitarily generally normally outwardly from the outer surface 124 and a spaced-apart upper flat surface 130 which extends unitarily radially outwardly from the outer nozzle surface 124 at an obtuse angle C of approximately 160 degrees. The distal ends of the two surfaces 128 and 130 terminate in an annular edge 132.

FIG. 4 shows yet another nozzle embodiment 216 which includes an outer nozzle surface 224 having an annular bead 226 with a rounded surface 228.

As shown in FIG. 5, the container 10 of the present invention is adapted to be used together with a dispensing assembly 34, such as hypodermic needle assembly, including a female hub 36 with a luer tapered inner surface 38 which defines an interior hub cavity 40 and terminates in a dispensing or draining aperture 42. A dispensing needle 44 is mounted to the hub 36 and extends outwardly from the apertured end of the hub 36. According to the invention, the hub cavity 40 and the nozzle 16 are sized to allow the hub 36 to be fitted over the nozzle 16 as described below. The resilient bead 26 is sized such that its diameter, combined with the diameter of the nozzle 16, is slightly greater than the diameter of the hub cavity 40 in the region of engagement.

The container/dispensing assembly combination of FIG. 5 is particularly useful in medical applications which require the transfer or mixing of the contents of the container 10 with the contents of another container such as, for example, an intravenous bag. The needle assembly 34 provides for the quick and efficient transfer of liquid contents in such applications.

The transfer procedure, of course, initially includes the step of opening the container 10 by twisting off the overcap 20 about the frangible web 22 so as to expose draining aperture 18.

The needle assembly 34 is then securely fitted to the container 10. Particularly, the hub 36 thereof is received and fitted over the nozzle 16 in a mating relationship where a portion of the inner surface 38 of the hub 36 is in abutting and contiguous relationship with the outer surface 24 of the nozzle 16 and a portion of the inner surface 38 of the hub 36 is in abutting and contiguous relationship with the compressed annular edge 32 and surfaces 28 and 30 of the bead 26.

The resiliency and compressibility of the bead 26 and, more particularly, the resiliency and compressibility of the molded thermoplastic material comprising the same, allows the hub 36 to be pressed over the bead 26 which, in turn, compresses the bead 26 and allows the bead 26 to exert a sealing force against the inner surface 38 of the hub 36 to provide both a secured friction fit and liquid seal between the hub 36 and the nozzle 16.

The apparatus and method for fabricating a container with a beaded nozzle according to the present invention is shown in FIGS. 6-8. As shown in FIG. 7, a parison segment 46 is extruded as generally described in U.S. Pat. Nos. 4,671,763 and 4,707,966 to Weiler between main molds 48 and 50 and seal molds 52 and 54.

The main molds include complementary inner surfaces conforming to the exterior shape of the body portion 12 of the container 10 and the seal molds include complementary inner surfaces 56 conforming to the exterior shape of the neck portion 14, the nozzle 16, and the overcap 20 of the container 10. Additionally, each of the seal molds 52 and 54 include a groove 58 conforming to the exterior shape of the bead 26 on the nozzle 16 and a passage 60 extending from the groove 58 and through the body of the respective seal molds. Although not shown, it is understood that the mold apparatus further includes an operatively associated assembly for creating a vacuum in the passages 60.

The body portion 12 of the container 10 is formed and filled as shown in FIG. 6 in a known manner, for example, as also described in U.S. Pat. Nos. 4,671,763 and 4,707,966 to Weiler, the disclosures of which are incorporated herein by reference to the extent relevant and not inconsistent herewith.

Next, the seal molds 52 and 54 are closed as shown in FIG. 7 to form and seal the nozzle 16 and the overcap 20 in a known manner, for example, as also described in U.S. Pat. Nos. 4,671,763 and 4,707,966 to Weiler.

As shown in FIG. 8, however, the size and the width of the groove 58 in the seal molds 52 and 54 coupled with the thickness of the parison 46 is such that the closing of the seal molds 52 and 54 is not sufficient to cause the parison 46 to fill the groove 58 to form the bead 26. As a result, it is necessary to create a vacuum in the passages 60 and the groove 58 to pull a portion of the parison 46 into the groove 58 as shown in FIG. 8 to form the bead 26 as the container 10 is sealed.

The formed, filled and sealed container 10 is subsequently removed from the apparatus as also described in U.S. Pat. Nos. 4,671,763 and 4,707,966 to Weiler.

The foregoing specification and the drawings are to be taken as illustrative but not limiting of the present invention. Still other nozzle and bead configurations and other apparatus and methods utilizing the spirit and scope of the present invention are possible, and will readily present themselves to those skilled in the art.

Claims (1)

I claim:
1. A method of forming a hermetically sealed thermoplastic dispensing container including a body filled with a liquid and a dispensing nozzle adapted to receive the hub of a dispensing assembly in a sealing relationship and having a unitary resilient annular bead about the periphery thereof and adapted to be compressed when the hub is received over said bead and said bead exerts a sealing force against the hub to provide a liquid seal between the hub and the nozzle, the method comprising the steps of:
extending a parison segment between main molds and seal molds respectively, said seal molds including a groove having a size and width conforming to the size and width of said bead on said nozzle and a vacuum passage extending from said groove through said seal molds;
closing the main molds and forming said body of said container;
filling said body with the liquid;
closing the seal molds and forming said nozzle and the size and width of the groove being such that the closing of the seal molds is not sufficient to cause the parison segment to fill the groove to form the bead; and
creating a vacuum through said passage in said seal molds for pulling said parison into said groove and forming said bead.
US09/569,274 1998-05-26 2000-05-11 Hermetically sealed container including a nozzle with a sealing bead Expired - Fee Related US6517768B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US09/084,804 US6068148A (en) 1998-05-26 1998-05-26 Hermetically sealed container including a nozzle with a sealing bead
US09/569,274 US6517768B1 (en) 1998-05-26 2000-05-11 Hermetically sealed container including a nozzle with a sealing bead

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/569,274 US6517768B1 (en) 1998-05-26 2000-05-11 Hermetically sealed container including a nozzle with a sealing bead

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/084,804 Division US6068148A (en) 1998-05-26 1998-05-26 Hermetically sealed container including a nozzle with a sealing bead

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US6517768B1 true US6517768B1 (en) 2003-02-11

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US09/569,274 Expired - Fee Related US6517768B1 (en) 1998-05-26 2000-05-11 Hermetically sealed container including a nozzle with a sealing bead

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US (2) US6068148A (en)
EP (1) EP0960820B1 (en)
JP (1) JPH11347101A (en)
AU (1) AU749384B2 (en)
DE (1) DE69915165T2 (en)

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Also Published As

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US6068148A (en) 2000-05-30
JPH11347101A (en) 1999-12-21
EP0960820A1 (en) 1999-12-01
DE69915165D1 (en) 2004-04-08
EP0960820B1 (en) 2004-03-03
AU749384B2 (en) 2002-06-27
DE69915165T2 (en) 2004-09-16
AU3225199A (en) 1999-12-02

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