US6386706B1 - Visual function testing with virtual retinal display - Google Patents
Visual function testing with virtual retinal display Download PDFInfo
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- US6386706B1 US6386706B1 US09/467,360 US46736099A US6386706B1 US 6386706 B1 US6386706 B1 US 6386706B1 US 46736099 A US46736099 A US 46736099A US 6386706 B1 US6386706 B1 US 6386706B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/02—Subjective types, i.e. testing apparatus requiring the active assistance of the patient
- A61B3/024—Subjective types, i.e. testing apparatus requiring the active assistance of the patient for determining the visual field, e.g. perimeter types
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/01—Head-up displays
- G02B27/017—Head mounted
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/01—Head-up displays
- G02B27/017—Head mounted
- G02B27/0172—Head mounted characterised by optical features
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F3/00—Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
- G06F3/01—Input arrangements or combined input and output arrangements for interaction between user and computer
- G06F3/011—Arrangements for interaction with the human body, e.g. for user immersion in virtual reality
- G06F3/013—Eye tracking input arrangements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/113—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining or recording eye movement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
- A61B5/0022—Monitoring a patient using a global network, e.g. telephone networks, internet
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
- A61B5/7267—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems involving training the classification device
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/01—Head-up displays
- G02B27/0101—Head-up displays characterised by optical features
- G02B2027/0132—Head-up displays characterised by optical features comprising binocular systems
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/01—Head-up displays
- G02B27/0101—Head-up displays characterised by optical features
- G02B2027/0132—Head-up displays characterised by optical features comprising binocular systems
- G02B2027/0136—Head-up displays characterised by optical features comprising binocular systems with a single image source for both eyes
Definitions
- This invention is in the field of optical testing of the sensitivity of the eye to light, in particular, visual field evaluation.
- glaucoma is one of the leading causes of blindness. Unlike cataract blindness, which is correctable with modern surgical techniques, blindness from glaucoma is permanent.
- the target organ of glaucoma is the optic nerve, which transmit signals of light from the retina to the brain. No known method is available for repairing, or transplanting, an injured optic nerve.
- a major diagnostic problem is that visual loss from glaucoma is almost without exception painless.
- the patient is not aware of the ravages of glaucoma until it is too late.
- the intraocular pressure in glaucoma is often not elevated (termed “low-tension” glaucoma), and therefore reliance upon tonometry to measure the patient's intraocular pressure frequently leads to a blatantly false sense of security.
- the patient is told that glaucoma is not present, when, in reality, the disease is insidiously attacking the patient's optic nerve, causing irreversible neurological damage to the visual system.
- Visual field testing is mandatory for glaucoma diagnosis and treatment.
- the current gold standard of measurement of optic nerve function is visual field testing, called “perimetry.”
- a problem with this technology is that far too many of the examiners performing visual field testing are inadequately trained to recognize subtle patterns in the patient's visual field indicative of glaucoma (or other neurological disease). Such misdiagnosis, which is unfortunately frequent, again gives the patient a false sense of security.
- the particularly sad aspect of glaucoma blindness is that it is generally preventable with proper diagnosis and treatment.
- the proposed invention which incorporates the use of telemedicine for real-time feedback and for autointerpretation of visual field performance, along with a Virtual Retinal Display, will play a major role in eliminating the all-too-common errors in visual field interpretation and the unnecessary blindness which accompanies such ignorance.
- glaucoma treatment can be instituted. Millions of patients will be spared the ravages of glaucoma.
- visual field testing is also used to test for a variety of neurological disorders, including cerebrovascular accidents (“strokes”), trauma, brain tumors, and other diseases.
- strokes cerebrovascular accidents
- the proposed invention which incorporates real-time feedback to monitor the patient's performance, and accurate, instantaneous diagnosis available through autointerpretation on a world-wide telemetric basis, addresses a major medical need.
- Visual field testing is mandatory for glaucoma diagnosis and treatment, as well as for confirmatory diagnosis of many neurological disorders affecting the optic pathways and the brain.
- Conventional visual field testing is performed utilizing a cupola-like globe, into which the patient fixates gaze during the testing process, attempting to respond to light stimuli which appear momentarily in the field of view.
- Major obstacles to patient friendliness are found with conventional visual field testers, and patients consider these methods of visual field analysis troublesome. More common are expressions of frustration, helplessness, boredom, claustrophobia, and, occasionally, anger.
- a head-mounted Virtual Retinal Display (VRD) system is utilized to present to a patient computer-controlled and sequenced test stimuli, thus measuring the patient's field of view (the “visual field”) and abnormalities thereof.
- the virtual retinal display projects a sequentially scanned train of light pulses in such a way as to “paint” an image onto the retina, much as a television raster method generates a television picture.
- the brain integrates the sequential signals received by the retina, to perceive the “picture” as a whole, which may be updated as frequently as desired by the associated computer, to carry on the visual field test, or tests of other visual functions.
- a gaze sensor which may be multi-element, is incorporated so as to allow the gaze to be detected in a small solid angular range and, within this range, the effective fixation is deemed to be maintained.
- the software in the associated computer provides the generation, via the virtual retinal display, of an interest-fixation icon which encourages the gaze to trace its motion within the allowed solid angle, thus avoiding fixation fatigue.
- the software keeps track of the location of the test point frame of reference within that solid angle of displacement, so as to provide accurate mapping of test data on the field of view presented to the retina.
- a significant advantage of the present system is that it provides relief from the stress of being required to concentrate one's gaze at a fixed location, without head movement. Freedom of movement of the head and body in this system reduces the stress and tedium of visual function testing, thereby enhancing test performance.
- the present invention can be used for performing quantitative visual field, and other visual function testing, on patients of ophthalmologists, optometrists, neurologists, and other medical practitioners.
- this new testing system achieves greatly increased brightness in daylight, and greatly enhanced image resolution. Also, since the head-gear can exclude light, ambient light may not be of concern, allowing visual function testing in any room, even allowing the testing of several subjects in the same room.
- the present invention can be employed with a neural network, or other autointerpretation system. Further, the present invention can also be employed with global network linkage via the Internet, or other suitable transmission method, for purposes of interpretation.
- the presently-described invention uses a data processing system to provide automatic interpretation of visual field and other test data received from testing apparatus in a system which can feature a virtual retinal display system.
- Using virtual reality and associated head-gear configuration in an interactive computerized system allows unprecedented freedom of movement of the head and body, thus minimizing or even eliminating the stress and fatigue common with conventional non-virtual reality visual field testing systems.
- the combination of automatic visual field interpretation with a head-mounted virtual retinal display system is unique and novel.
- the use of telemedicine for centralized interpretation of visual field testing at remote locations, and interactively modulating the performance of the patient is likewise unique and novel.
- Audio feedback stimuli such as voice, or a tone or series of tones, or tactile feedback stimuli, such as a vibration, monitor the test performance in real-time.
- These stimuli are generated and controlled by software in an associated computer, which receives interactive feedback stimuli from the patient.
- the content of the software is dictated by the need to provide technically acceptable protocols, such as for examining wide and narrow fields of view, selected areas, such as the blind spot or the fovea, and measurements of thresholds for sensitivity to light intensity, or, if desired, color.
- Active feedback sensing alerts the system to patient loss of attention in general, or loss of fixation in particular, for notation and reiteration of test stimuli.
- the system is configured to allow test stimuli to be presented to one eye at a time, or to both eyes simultaneously. Individual test points are reiterated when a result is found to be inconsistent with a predetermined norm.
- FIG. 1 is a schematic illustration of the apparatus of the present invention
- FIG. 2A is a schematic illustration of the apparatus shown in FIG. 1, with a curved Fresnel mirror redirection element;
- FIG. 2B is a schematic illustration of the apparatus shown in FIG. 1, with a flat Fresnel mirror redirection element;
- FIG. 2C is a schematic illustration of the apparatus shown in FIG. 1, with a dual mirror/Fresnel lens redirection element;
- FIG. 3A is a schematic illustration of the apparatus shown in FIG. 1, with a beam splitter;
- FIG. 3B is a schematic illustration of the apparatus shown in FIG. 1, with dual virtual retinal displays;
- FIG. 4A is an illustration of the vertical field of view
- FIG. 4B is an illustration of the horizontal field of view
- FIG. 5 is a schematic diagram of the information flow in the system of the present invention.
- FIG. 6 is a schematic diagram of the automatic interpretation portion of the system of the present invention.
- the present invention for performing visual function testing incorporates a technology called virtual retinal display, as disclosed in U.S. Pat. No. 5,467,104, and in U.S. Pat. No. 5,596,339, which are incorporated herein by reference.
- Virtual retinal display technology utilizes a photon generator and scanners to create a raster-type pattern consisting of pixels containing signal information. Horizontal and vertical scanners are used to direct the photon stream, and optical elements are employed to project the scanning beam of light through the patient's pupil onto the retina to form an image. Either coherent or non-coherent light may be used. Images are created by the system's computer software, and full-color images are possible.
- red, green, and blue light sources are used, and the desired color is obtained by modulation and mixing of the three light sources.
- the virtual retinal display projects the image directly onto the human retina, allowing the user to ‘see’ the image without viewing it on a secondary surface.
- Currently known applications for VRD technology are heads-up-displays, color projection systems for entertainment, or flight training simulators.
- the present invention incorporates a virtual retinal display to create an environment of virtual reality, resulting in a visual function testing system of greatly increased capability.
- Virtual reality is a term applied loosely to the experience of an individual when exposed to the appearance of surroundings which are presented by interactive apparatus for stimulation of the senses.
- the primary cues are usually visual, supplemented by audio, and the feedback to the apparatus is generally by physical movements of the individual experiencing the virtual reality, such as pressing a button or a switch, or speaking into a microphone.
- the virtual reality visual field measuring method and apparatus of the present invention uses a head-mounted apparatus for the presentation of visual and audio stimuli to a patient.
- the head-gear apparatus configured as goggles, a facemask, or other suitable head-gear, which remains in a fixed spatial relationship to the patient's head during testing of the visual field, is adjustable to suit the individual patient, and is mounted on the patient's head by conventional means.
- a virtual retinal display is incorporated into the head-gear, so as to project through the pupil of the patient, via scanners, a light signal consisting of pixels, with color, if desired, so as to provide a full field of view for each eye.
- the virtual retinal display in essence, “paints” the desired symbol, icon, dot of light, or other imagery, directly onto the patient's retina.
- the visual image which is projected onto the retina of the patient by the virtual retinal display can have both relatively fixed image information, and superimposed visual stimuli, which may vary in time, place, size, shape, color, and intensity. These stimuli are generated and controlled by software in an associated computer, which receives interactive feedback from the patient. Such feedback includes, but is not limited to, direction of gaze sensing, eyelid movement and blinking, and audio and hand pressure signals as the patient responds to visual stimuli presentations.
- the head-gear is provided with an integral microphone and speaker, for audio communication and feedback, and a multi-element gaze-aim sensor array.
- This ensemble is connected, by appropriate means, to a computer which provides the necessary visual and audio stimuli for the patient, and which receives the feedback responses to enable interactive functioning of the system.
- a hand-operated switch is incorporated.
- Protocols provide for examining wide and narrow fields of view, selected areas, such as the blind spot or the fovea, and measurements of thresholds for sensitivity to light intensity, or, if desired, color, such as blue-on-yellow, or yellow-on-blue, or other color combinations. Measurements are usually made for one eye at a time, each looking at the same, or similar, fields of view.
- Any desired imagery can be provided in the “background,” or a conventional, uniform featureless field can be used.
- the background in various quadrants/areas may include patterns, or low-contrast images, and if present, these images may move quickly or slowly. Further, the intensity or color of the background may be changed, and any image, color, or brightness can be modulated over time. The shape, intensity, color, location, and duration of the superimposed test points also may be changed, and these characteristics can be modulated over time.
- the foveal region of the retina contains a high density of cones, the color sensitive receptors, and the rest of the retina is populated mainly by rods, which are relatively insensitive to color. Therefore, the use of a test stimulus of a first color superimposed on a background of a second color is a beneficial practice to be incorporated in some visual field testing, especially in peripheral visual field testing. This practice is known to improve the sensitivity of visual field testing, resulting in earlier detection of glaucomatous damage. This advantage can be employed by using various combinations of colors. It has been determined that a particularly beneficial combination of colors is the use of a blue test stimulus on a yellow background.
- a test stimulus of a first color preferably blue
- a background of a second color preferably yellow
- the second eye can be presented with only a background of the second color. Presenting the color-on-color image for only one eye can be useful in preventing retinal rivalry, thereby reducing the stress imposed upon the patient during testing.
- Active feedback sensing alerts the system to patient loss of attention in general, or loss of fixation in particular, for notation and reiteration of test stimuli.
- the software allows optional restful imagery to be provided in the “background,” in addition to a conventional, uniform featureless field.
- the imagery in various quadrants or areas may be patterns, or low-contrast images, and may move quickly or slowly, and may have intensity, color, or temporal modulation.
- a hard-copy printout documenting patient responses is provided for the physician's records.
- An element of this virtual retinal display testing system is that it allows the patient the freedom to shift his or her gaze, while in the test mode, without disruption of the process, thus relieving one of the causes of patient stress.
- Another feature provided is the ability to modulate the background scene brightness, contrast, color, optical stimulus size and detail, and duration of the test stimuli, all of which serve to relieve fatigue of the patient.
- the patient may move around bodily, since the head-gear is portable and, in addition, electrical interface to the computer may be wireless.
- both eyes can receive virtual retinal display images simultaneously, or separately and independently, provision is made to supply test stimuli to the specific eye being measured.
- the non-testing portion of the formed image can be generated separately for each eye by means of individual virtual retinal displays, or may be provided by a common VRD source and directed to both eyes simultaneously via a beam splitter.
- One embodiment employs a single virtual retinal display apparatus and a beam splitter.
- non-varying background imagery is created equally in both eyes.
- odd images can correspond to the left eye
- even images can correspond to the right eye.
- test stimuli would be non-simultaneously added to the odd images to test the left eye, or to the even images to test the right eye, thus eliminating the need to occlude either eye while the fellow eye is being tested.
- two virtual retinal displays are utilized, with one VRD projecting onto the retina of one eye, and the second VRD projecting onto the retina of the fellow eye.
- Appropriate software controls the testing in such a way that each eye receives test stimuli independently and non-simultaneously, eliminating the need for ocular occlusion.
- the test stimuli are directed to the specific eye undergoing testing from a separate VRD source.
- the virtual retinal display system which is used for forming the wide angle virtual image has a demanding entrance angle requirement.
- This requirement can be met by trading image resolution for wider angle, for example, by reducing the numerical aperture.
- optical imaging elements such as a Fresnel lens, or mirror, in which the large curvatures needed are obtained in a thin element, without the penalty of a bulky conventional lens.
- high resolution image formation is not a necessity, since the objective is to examine extramacular retinal regions and assess function thereof.
- the central region of a Fresnel lens can provide sufficient resolution to accomplish the task.
- FIG. 1 shows the preferred embodiment, in which a head-mounted apparatus 12 , such as goggles, facemask or other suitable head-gear, is connected to a computer 13 .
- Software on the computer 13 is written to cause the computer 13 to generate a signal for the ultimate display of dots, symbols, or other imagery, through the pupillary aperture onto the patient's retinae.
- These computerized image signals are transmitted to the virtual retinal display 3 , which generates the visual images.
- the visual images are transmitted via a system of deflection and directing optics 23 , a redirection mirror 33 , and then to a curved Fresnel redirection mirror 33 a , and thence into the eye through the pupil.
- the system of deflection and directing optics 23 provides angular deflection of the image beam in vertical and horizontal axes to direct the photon beam to the desired location upon the retina.
- a beam splitter 53 as depicted in FIG. 3A, can be used to split the image beam into two separate beams for projection onto the two retinae.
- the computer 13 also generates and transmits an audio signal to a head-mounted earphone 14 .
- a microphone 15 provides a feedback audio response from the patient to the computer 13 .
- a hand-actuated switch 16 provides manual feedback from the patient to the computer 13 .
- An optical sensor 17 mounted in the direction of gaze, provides gaze direction feedback to the computer 13 .
- FIGS. 2A, 2 B, and 2 C depict alternate Fresnel optical element configurations for redirecting the image beam.
- the preferred embodiment is depicted in FIG. 2A, in which the final redirecting optical element is a curved Fresnel mirror 33 a .
- An alternate embodiment is shown in FIG. 2B, in which a flat Fresnel mirror 33 b , is incorporated.
- a further alternate embodiment is illustrated in FIG. 2C, showing dual redirecting mirrors 33 , from which the stimulus passes through a curved Fresnel lens 43 , en route to the eye.
- FIGS. 2A, 2 B, and 2 C are intended to be merely a few examples of possible redirecting element configurations.
- FIG. 3A depicts a schematic view of the preferred embodiment, shown from the top to illustrate the projection of separate beams into the two eyes of the patient.
- This embodiment utilizes a single virtual retinal display 3 , and a single system of deflection and direction optics 23 , with the image passing through a beam splitter 53 , which splits the beam into two image beams for further transmission to both eyes.
- the image beam Under the control of the computer 13 , the image beam can be projected onto only one eye at a time, if desired.
- both eyes receive computer-directed, sequenced stimuli from a single virtual retinal display 3 , and from a single system of deflection and directing optics 23 . This is more economical, lighter, and much more patient-friendly.
- FIG. 3B shows an alternate embodiment incorporating dual virtual retinal displays 3 , dual deflection and directing optics systems 23 , and an absence of a beam splitter.
- FIG. 4A illustrates a vertical angular field of view 7 , over which the image can be displayed.
- FIG. 4B shows a horizontal angular field of view 11 , over which the image can be displayed.
- the system of the present invention includes a local visual field test apparatus 5 , which can include a head mounted virtual retinal display apparatus 12 , and a local processing system 13 which can form an integral part of the head-mounted diagnostic apparatus 12 .
- the expert supervision of the testing process and interpretation of the results can be performed via long-distance transmission vehicles, such as the Internet, thus providing, telemetrically, not only essentially instantaneous autointerpretation, but also telemetric monitoring of the patient's performance of the test in real time.
- a central world-wide processing/data collection system 18 (consisting of a single station or a series of stations, such as one for the United States, one for Japan, one for France, etc.) can be linked via the Internet to a multitude of local test stations 5 and provide multiweb-like integration.
- the data processing portion of the system incorporates the local processing system 13 and the central processing system and data repository 18 , to provide the classification of the visual field test data in terms of presence or absence of all diseases, or any particular disease (e.g., glaucoma).
- the data processing portion of the system also may assign a probability of detection and/or a numerical value indicating the severity of the disease. This provides a tool for monitoring disease progression.
- Functions of the local processing system include the following:
- pre-processing of the patient response data such as elimination of those measurement points (patient's responses) that are deemed inadequate, normalization to a pre-defined standard, and formatting for transmission to the remote processing system.
- Functions of the remote processing system include the following:
- the central processing/data collection system 18 includes an automated interpretation system, incorporating a neural network, which functions as shown in FIG. 6 . Integration of a multitude of local testing stations 5 into a world-wide system results in a telemedicine system which is “intelligent” in that ongoing data accumulation and analyses thereof improve the computational model and provide, over time, increasingly more accurate identification of very subtle disease processes.
- a database of empirical, semi-empirical, or simulated visual field test data is used to build a neural network model of the visual field test data.
- This model when applied to previously unseen test results, is capable of automatically interpreting and classifying the test data in terms of the presence and/or severity of abnormal (diseased) regions and states.
- the auto-interpretation system utilizes the results of visual stimuli (consisting of dots, symbols, shapes, or patterns, with or without color, etc.) presented to the patient, which are converted into numerical representation for data processing, such as in the standard automated perimetry schemes (cf. Humphrey Field Analyzer).
- Other inputs, resulting from standard pre-processing of the test data, such as visual field indices, can also be employed by the neural network. Inclusion of all available individual components of perimetric examination is useful for proper clinical interpretation of the visual test examination.
- the information provided to the neural network may include:
- ancillary data such as pupil size during testing, the patient's age, and visual acuity
- visual field indices such as average deviation of sensitivity at each test location from age-adjusted normal population values, the index of the degree of irregularity of visual field sensitivity about the normal slope, and sensitivity analysis of clusters of points;
- the preferred embodiment of the neural network based auto-interpretation system is shown in FIG. 6 .
- the system consists of some or all of the modules described below.
- the data reduction module 22 is employed to reduce the size of the data vector presented to the neural network classifier.
- This module employs singular value decomposition, principal component analysis (PCA), learning vector quantization, or other clustering and data size reduction methods. Typically, application of any of these methods results in at least a two-fold decrease in the size of the data vector. Such a reduction increases the ability of the neural network to generalize the data contained in the training set.
- the clustering and linear decomposition methods (such as PCA) are also useful for ‘novelty detection’, i.e., for establishing if the current data vector is outside the region encompassed by the training data set.
- the neural network model is likely to fail for such data and thus, the ability to detect novelty is crucial for minimizing the number of erroneous interpretations.
- the data normalization module 24 performs amplitude normalization of the data presented to the neural network.
- the neural network classifier module 26 performs pattern recognition and classification of the visual field test data.
- the probability of classification (or, degree of membership) is quantified for each of the classes considered in the model.
- a non-linear classification scheme exemplified by the multilayer perceptron or the radial/ellipsoidal basis function neural network is used.
- other classification schemes such as multivariate analysis, linear regression, statistical classifiers or discriminators (such as Bayesian classifiers) may also be employed.
- the neural networks are especially useful for the automatic application scheme because they provide a non-parametric, empirical model of the visual field test data and are computationally non-intensive, i.e., the classification computations can be performed quickly on inexpensive computers.
- the neural network may be a binary classification system, which will indicate the presence or absence of a particular disease, such as glaucoma, or a multi-class system, which provides recognition and classification of a large variety of possible visual field disorders, including, but not limited to, neurological tumors, cerebrovascular accidents and strokes, optic nerve disorders, compression syndromes of the optic nerve or optic chiasm, demyelinating diseases, and diseases of the retina.
- a binary classification system which will indicate the presence or absence of a particular disease, such as glaucoma
- a multi-class system which provides recognition and classification of a large variety of possible visual field disorders, including, but not limited to, neurological tumors, cerebrovascular accidents and strokes, optic nerve disorders, compression syndromes of the optic nerve or optic chiasm, demyelinating diseases, and diseases of the retina.
- the implementation may be in the form of a single-level neural network system or a hierarchical system.
- the single-level system all the input data, which are deemed relevant for the interpretation task, are inputted and processed simultaneously.
- the hierarchical system different input data types are modeled by dedicated separate sub-systems, and these outputs are subsequently fused through a suitable computational architecture, to produce the final classification result.
- the output module 28 creates a graphical representation of the visual field test data, such as isopter/scotoma plots, or gray scale or color-coded plots, with superimposed identification of the regions that the system classified as abnormal.
- the automatic interpretation system is an expert system trained on a set of empirical, semi-empirical, and/or simulated data.
- the construction of a proper training database is essential for achieving good performance of the interpretation system (good sensitivity and specificity).
- the training database may contain all, or any, of the following types of visual field data:
- simulated data i.e., data that are constructed to simulate the real-world results of a visual field test for both normal and abnormal visual fields.
- Training of the classification system is performed off-line with active participation of a human expert. That is, all visual field test data in the training database are examined by an expert and the medical diagnosis is verified and validated before the data is used to build the neural network model.
- the centralized processing enables collection of a large number of diverse examples of normal and abnormal visual field test data.
- the novelty detection capability of the system alerts the system custodian to the necessity for expert examination of the novel data. After completion of such examination, the data may be included in the model by including the new data in the training database and re-training the system.
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Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/467,360 US6386706B1 (en) | 1996-07-31 | 1999-12-20 | Visual function testing with virtual retinal display |
PCT/US2000/014685 WO2000072745A1 (en) | 1999-05-27 | 2000-05-26 | Visual function testing with virtual retinal display |
CA002338417A CA2338417A1 (en) | 1999-05-27 | 2000-05-26 | Visual function testing with virtual retinal display |
US09/900,764 US6592222B2 (en) | 1996-07-31 | 2001-07-02 | Flicker and frequency doubling in virtual reality |
Applications Claiming Priority (8)
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Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5461436A (en) | 1993-10-29 | 1995-10-24 | Humphrey Instruments, Inc. | Color field test with occlusion of non-tested eye |
US5467104A (en) | 1992-10-22 | 1995-11-14 | Board Of Regents Of The University Of Washington | Virtual retinal display |
US5589897A (en) | 1995-05-01 | 1996-12-31 | Stephen H. Sinclair | Method and apparatus for central visual field mapping and optimization of image presentation based upon mapped parameters |
US5596339A (en) | 1992-10-22 | 1997-01-21 | University Of Washington | Virtual retinal display with fiber optic point source |
DE19540802A1 (en) | 1995-11-02 | 1997-05-07 | Johannes Braeuning | Device for testing at least one visual function in eye of patient |
US5701132A (en) | 1996-03-29 | 1997-12-23 | University Of Washington | Virtual retinal display with expanded exit pupil |
US5751465A (en) | 1994-10-26 | 1998-05-12 | University Of Washington | Miniature optical scanner for a two axis scanning system |
US5894339A (en) | 1997-03-31 | 1999-04-13 | Nidek Co., Ltd. | Apparatus for presenting a test chart |
US5903397A (en) | 1998-05-04 | 1999-05-11 | University Of Washington | Display with multi-surface eyepiece |
US6045227A (en) * | 1998-09-03 | 2000-04-04 | Visionrx.Com, Inc. | Multi-functional visual testing instrument |
US6139152A (en) * | 2000-02-28 | 2000-10-31 | Ghahramani; Bahador | Electronic depth perception testing system and apparatus for conducting depth perception tests |
US6290357B1 (en) * | 1999-03-31 | 2001-09-18 | Virtual-Eye.Com, Inc. | Kinetic visual field apparatus and method |
-
1999
- 1999-12-20 US US09/467,360 patent/US6386706B1/en not_active Expired - Fee Related
-
2000
- 2000-05-26 CA CA002338417A patent/CA2338417A1/en not_active Abandoned
- 2000-05-26 WO PCT/US2000/014685 patent/WO2000072745A1/en active Application Filing
Patent Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5467104A (en) | 1992-10-22 | 1995-11-14 | Board Of Regents Of The University Of Washington | Virtual retinal display |
US5596339A (en) | 1992-10-22 | 1997-01-21 | University Of Washington | Virtual retinal display with fiber optic point source |
US5659327A (en) | 1992-10-22 | 1997-08-19 | Board Of Regents Of The University Of Washington | Virtual retinal display |
US5461436A (en) | 1993-10-29 | 1995-10-24 | Humphrey Instruments, Inc. | Color field test with occlusion of non-tested eye |
US5751465A (en) | 1994-10-26 | 1998-05-12 | University Of Washington | Miniature optical scanner for a two axis scanning system |
US5589897A (en) | 1995-05-01 | 1996-12-31 | Stephen H. Sinclair | Method and apparatus for central visual field mapping and optimization of image presentation based upon mapped parameters |
DE19540802A1 (en) | 1995-11-02 | 1997-05-07 | Johannes Braeuning | Device for testing at least one visual function in eye of patient |
US5701132A (en) | 1996-03-29 | 1997-12-23 | University Of Washington | Virtual retinal display with expanded exit pupil |
US5969871A (en) | 1996-03-29 | 1999-10-19 | University Of Washington | Virtual retinal display with lens array for expanding exit pupil |
US5894339A (en) | 1997-03-31 | 1999-04-13 | Nidek Co., Ltd. | Apparatus for presenting a test chart |
US5903397A (en) | 1998-05-04 | 1999-05-11 | University Of Washington | Display with multi-surface eyepiece |
US6045227A (en) * | 1998-09-03 | 2000-04-04 | Visionrx.Com, Inc. | Multi-functional visual testing instrument |
US6290357B1 (en) * | 1999-03-31 | 2001-09-18 | Virtual-Eye.Com, Inc. | Kinetic visual field apparatus and method |
US6139152A (en) * | 2000-02-28 | 2000-10-31 | Ghahramani; Bahador | Electronic depth perception testing system and apparatus for conducting depth perception tests |
Non-Patent Citations (63)
Title |
---|
Adams, A.; Clinical Measures of Central Vision Function in Glaucoma and Ocular Hypertension; Jun., 1987; Arch Ophthalmol, vol. 105; pp. 782-787. |
Adams, A.; Spectral Sensitivity and Color Discrimination Changes in Glaucoma and Glaucoma-suspect Patients; Oct., 1982; Invest. Ophthalmol. Vis. Sci.; vol. 23, No. 4; pp. 516-524. |
Airaksinen, P.; Color Vision and Retinal Nerve Fiber Layer in Early Glaucoma; Feb., 1986; American Journal of Ophthalmalogy vol. 101; pp. 208-213. |
Applegate, R.; Entoptic Evaluation of Diabetic Retinopathy; Apr., 1997; Investigative Ophthalmology & Visual Science, vol. 38, No. 5; pp. 783-791. |
Applegate, R.; Entoptic Visualization of the Retinal Vasculature Near Fixation; Oct., 1990; Investigative Ophthalmology, vol. 31, No. 10; pp. 2088-2098. |
Bartley, S.; Vision A Study of its Basis; 1963; pp. 57-71. |
Bethke, W.; The Power of Second Sight; Jan., 1997; Review of Ophthalmology; p. 21. |
Bottari, J.; Blue Field Entoptic Study: Diurnal and Long Term Fluctuation of Leukocyte Characteristics; www.cs.tufts.ecu/~vanvo/ARVO96B.html; 1 p. |
Bottari, J.; Blue Field Entoptic Study: Diurnal and Long Term Fluctuation of Leukocyte Characteristics; www.cs.tufts.ecu/˜vanvo/ARVO96B.html; 1 p. |
Breton, M.; Age Covariance Between 100-Hue Color Scores and Quantitative Perimetry in Primary Open Angle Glaucoma; May, 1987; Arch Ophthalmol, vol. 105; pp642-645. |
Burstein, R.; Virtual Retinal Display; 1997; HITLab Review, No. 10; 2 pages. |
Business Communications Co.; Display Detects Retinal Diseases; Jun., 1999; Microtechnology NewsVvol. 5, No. 7; 2 pages. |
Caprioli, J.; Early Diagnosis of functional Damage in Patients With Glaucoma; Jan., 1997; Arch Ophythalmol vol. 115; pp. 113-114. |
CMP Media Inc.; Two Eye Virtual Retinal Display Tech;Jun., 1997; EE Times Issue 957; 1 page. |
Davies, E.; Macular Blood Flow Response to Acute Reduction of Plasma Glucoses in Diabetic Patients Measured by the Blue Light Entoptic Technique; Mar., 1989; Ophthalmalogy vol. 97 No. 2; pp. 160-164. |
Donnelly, J.; Here's Light in Your Eye, Kid; Mar., 1999; Military Training Technology, vol. 4, Issue 1; 3 pages. |
Drance, S.; Acquired Color Vision Changes in Glaucoma; Jul. 1980/Arch Ophthalmol vol. 99; pp. 829-831. |
Falcao-Reis, F.M.; Mar., 1991; Macular Colour Sensitivity in Ocular Hypertension and Glaucoma; British Journal of Ophthalmology; 1991, 75; pp. 598-602. |
Fellius, J.; Functional Characteristics of Blue-on-Yellow Perimetric Thresholds in Glaucoma; Feb. 8, 1995; Investigative Ophthalmology & Visual Science, vol. 36, No. 8; pp. 1665-1674. |
Flammer, J.; Correlation Between Color Vision Scores and Quantitative Perimetry in Suspected Glaucoma; Jan., 1983; Arch Ophthalmol, vol. 102; pp. 38-39. |
Geddes, J.; New Personal Display Technology; May, 1999; Image Society Feature Articles; www.public.asu.edu/~image/NEWS/NewsFeatureA.html; 2 pages. |
Geddes, J.; New Personal Display Technology; May, 1999; Image Society Feature Articles; www.public.asu.edu/˜image/NEWS/NewsFeatureA.html; 2 pages. |
Gunduz, K.; Color Vision Defects in Ocular Hypertension and Glaucoma; Jan., 1988; Arch Ophthalmol vol. 106; pp. 929-935. |
Hamill, T.; Correlation of Color Vision Deficits and Observable Changes in the Optic Disc in a Population of Ocular Hypertensives; Jun., 1984; Arch Ophthalmol vol. 102; pp. 1637-1639. |
Hart, W.; Color Contrast Perimetry; Jan. 1983; Investigative Ophthalmology & Visual Science vol. 25; pp400-413. |
Hart, W.; Color Contrast Perimetry; Nov., 1984; Ophthalmology vol. 92, No. 6; pp. 768-776. |
Hart, W.; Color Perimetry of Glaucomatous Visual Field Defects; Oct., 1983; Ophthalmalogy vol. 91, No. 4; pp. 338-346. |
Hart, W.; Glaucomatous Visual Field Damage; Feb. 1989; Investigative Ophthalmology & Visual Science, vol. 31, No. 2, pp. 359-367. |
Heron, G., Central Visual Fields For Short Wavelength Sensitive Pathways in Glaucoma and Ocular Hypertension;Jul. 1987; Investigative Ophthalmology & Visual Science vol. 29 No. 1; pp 64-72. |
Humphrey Instruments; Humphrey Blue-Yellow Perimetry; advertisement; date unknown; 1 page. |
Humphrey Instruments; Humphrey Field Analyzer II; date unknown; www.humphrey.com; 1 page. |
Interzeag AG; Blue/Yellow Perimetry; Jun., 1997; Ocular Surgery News; 1 page. |
Interzeag AG; Clairvoyant Octopus; Jul. 1997; Ocular Surgery News; 2 pages. |
Johnson, C.; Blue-on-Yellow Perimetry Can Predict the Development of Glaucomatous Visual Field Loss; Jan. 1993; Arch Ophthalmol vol. 111; pp. 645-650. |
Johnson, C.; Progression of Early Glaucomatous Visual Field Loss as Detected by Blue-on-Yellow and Standard White-on-WhiteAutomated Perimetry;Jan. 1993; Arch Ophthalmol vol. 111; pp. 651-656. |
Johnson, C.; Short-Wavelength Automated Perimetry in Low-,Medium-. and Hight-risk Ocular Hypertensive Eyes; Jan. 1995;Arch Ophthalmol vol. 113; pp. 70-76. |
Kollin, J.; Optical Engineering Challenges of the Virtual Retinal Display; 1995; Published by Society of Photo-Optical Instrumentation Engineers; 12 pages. |
Lewis R.; Automated Perimetry and Short Wavelength Sensitivity in Patients with Asymmetric Intraocular Pressures; Nov. 1992; Graefe's Archive for Clinical and Experimental Ophthalmology; pp. 274-278. |
Logan, N.; Detecting Early Glaucomatous Visual Field Changes With A blue Stimulus; Jan. 1983; American Journal of Ophthalmology vol. 95; pp. 432-434. |
Massengill, R., GlobalMed VF-2400 Telemedicine/Autointerpretation System for Visual Function Testing; Nov. 1998; Press release for the American Academy of Ophthalmology Meeting; 7 pages. |
Microvision; Microvision and Boeing Collaborate to Develop Cockpit of the Future; Mar. 1999; www.mvis.com; 2 pages. |
Microvision; Microvision Announces Breakthrough with Super-Bright Light-Emitting Diodes; Nov. 1999; www.mvis.com; 2 pages. |
Microvision; Microvision Chosen by Wallace-Kettering Neuroscience Institute; Au. 1998; www.mvis.com; 4 pages. |
Microvision; Microvision Delivers Groundbreaking Helmet-Mounted Display; Mar. 1999; www.mvis.com; 2 pages. |
Microvision; Virtual Retinal Display; May 1999; www.mvis.com; 9 pages. |
Microvision; Web Site and Related Press Releases; Nov. 1999; www.mvis.com; Entire volume. |
Mindel, J.; Visual Field Testing With Red Targets; Jul. 1982; Arch Ophthalmol vol. 101; pp. 927-929. |
Moses, R.; Entoptic and Allied Phenomena; 1981; Adler's Physiology of the Eye; pp. 562-574. |
Moss, I.; The Influence of Age-Related Cataract on Blue-onYellow Perimetry; Nov. 1994; Investigative Ophthalmology & Visual Science vol. 36, No. 5; pp. 764-773. |
Motolko, M.; The Early Psychophysical Disturbances in Chronic Open-angle Glaucoma; Nov. 1981; Arch Ophthalmol vol. 100; pp. 1632-1634. |
Ocular Surgery News; Beta Sites; Apr. 1999; 1 page. |
Plummer, D.; The Utility of Entoptic Perimetry as a Screening Test for Cytomegalovirus Retinitis; Feb. 1999; Arch Ophthalmol vol. 117; pp. 202-207. |
Quigley, H.; Chronic Glaucoma Selectively Damages Large Optic Nerve Fibers; Oct. 1986; Investigative Oophthalmology & Visual Science vol. 28 No. 6; pp. 913-920. |
Sample, P.; Color Perimetry for Assessment of Primary Open-Angle Glaucoma; Sep. 1990; Investigative Ophthalmology & Visual Science vol. 31 No. 9; pp. 1869-1875. |
Sample, P.; Isolating the Color Vision Loss in Primary Open-angle Glaucoma; Sep. 1988; American Journal of Ophthalmology vol. 106 No. 6; pp. 686-691. |
Sample, P.; Progressive Color Visual Field Loss in Glaucoma; Dec. 1991; Investigative Ophthalmology & Visual Science vol. 33 No. 6; pp. 2068-2071. |
Sample, P.; Short-wavelength Automated Perimetry Without Lens Density Testing; May 1994; American Journal of Ophthalmology vol. 118 No. 5; pp. 632-641. |
Sample, P.; Short-wavelength Color Visual Fields in Glaucoma Suspects at Risk; Oct. 1992; American Journal of Ophthalmology vol. 115 No. 2; pp. 225-233. |
Stoll, D.; Retinal Scanning Leads HMD Race; Dec. 1998; Photonics Online; 7 pages. |
Wild, J.; The Statistical Interpretation of Blue-on-Yellow Visual Field Loss; Jul. 1994; Investigative Ophthalmology & Visual Science vol. 36 No. 7; pp. 1398-1410. |
Yamazaki, Y.; A Comparison of the Blue Color Mechanism in High-and Low-tension Glaucoma; Jun. 1988; Ophthalmology vol. 96 No. 1; pp. 12-15. |
Yamazaki, Y.; Correlation Between Color Vision and Highest Intraocular Pressure in Glaucoma Patients; Jul. 1988; American Journal of Ophthalmology Vo. 106 No. 4; pp 397-399. |
Yu, T.; Peripheral Color Contrast; Apr. 1991; Investigative Ophthalmology & Visual Science vol. 32 No. 10; pp. 2779-2789. |
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US20030071970A1 (en) * | 2001-10-17 | 2003-04-17 | Carl Zeiss Meditec Ag | Ophthalmologic examination instrument |
US7753524B2 (en) | 2002-02-08 | 2010-07-13 | Novavision, Inc. | Process and device for treating blind regions of the visual field |
US7682021B2 (en) | 2002-02-08 | 2010-03-23 | Novavision, Inc. | System and methods for the treatment of retinal diseases |
US7367671B2 (en) | 2002-02-08 | 2008-05-06 | Novavision, Inc. | Process and device for the training of human vision |
US20060283466A1 (en) * | 2002-02-08 | 2006-12-21 | Bernhard Sabel | System and methods for the treatment of retinal diseases |
US20070216865A1 (en) * | 2002-02-08 | 2007-09-20 | Novavision, Inc. | Process and Device for Apportioning Therapeutic Vision Stimuli |
US20070182928A1 (en) * | 2002-02-08 | 2007-08-09 | Novavision, Inc. | Process and Device for Treating Blind Regions of the Visual Field |
US7404641B2 (en) | 2002-03-28 | 2008-07-29 | Heidelberg Engineering Optische Gmbh | Method for examining the ocular fundus |
DE10313975B4 (en) * | 2002-03-28 | 2007-08-23 | Heidelberg Engineering Gmbh | Procedure for examining the fundus |
US20040193070A1 (en) * | 2003-03-28 | 2004-09-30 | Meyer Schilder | Systems and methods for detecting and mapping disorders of the macular portion of the retina |
US20060092377A1 (en) * | 2004-06-15 | 2006-05-04 | Todd David P | Method and device for guiding a user's head during vision training |
US7642990B2 (en) | 2004-06-15 | 2010-01-05 | Novavision, Inc. | Method and device for guiding a user's head during vision training |
US20060033879A1 (en) * | 2004-07-01 | 2006-02-16 | Eastman Kodak Company | Scanless virtual retinal display system |
US7375701B2 (en) | 2004-07-01 | 2008-05-20 | Carestream Health, Inc. | Scanless virtual retinal display system |
US7639146B2 (en) * | 2004-09-29 | 2009-12-29 | Baura Gail D | Blink monitor for detecting blink occurrence in a living subject |
US20060077064A1 (en) * | 2004-09-29 | 2006-04-13 | Baura Gail D | Blink monitor for detecting blink occurrence in a living subject |
WO2006074434A2 (en) * | 2005-01-06 | 2006-07-13 | University Of Rochester | Systems and methods for improving visual discrimination |
US7549743B2 (en) | 2005-01-06 | 2009-06-23 | University Of Rochester | Systems and methods for improving visual discrimination |
WO2006074434A3 (en) * | 2005-01-06 | 2006-12-07 | Univ Rochester | Systems and methods for improving visual discrimination |
US20080278682A1 (en) * | 2005-01-06 | 2008-11-13 | University Of Rochester | Systems and methods For Improving Visual Discrimination |
US20070038142A1 (en) * | 2005-03-30 | 2007-02-15 | Todd David P | Method and device for delivering visual stimuli with head mounted display during vision training |
WO2006105358A1 (en) * | 2005-03-30 | 2006-10-05 | Novavision, Inc. | Method and device for delivering visual stimuli with head mounted display during vision training |
US9050409B2 (en) * | 2005-12-12 | 2015-06-09 | Roche Diagnostics International Ag | Patient device with separate user interface |
US20070165020A1 (en) * | 2005-12-12 | 2007-07-19 | Ulrich Haueter | Patient Device with Separate User Interface |
US20070171372A1 (en) * | 2005-12-16 | 2007-07-26 | Nonavision, Inc. | Adjustable device for vision testing and therapy |
US7594728B2 (en) | 2005-12-16 | 2009-09-29 | Novavision, Inc. | Adjustable device for vision testing and therapy |
US20080013047A1 (en) * | 2006-06-30 | 2008-01-17 | Novavision, Inc. | Diagnostic and Therapeutic System for Eccentric Viewing |
US7748846B2 (en) | 2006-07-25 | 2010-07-06 | Novavision, Inc. | Dynamic fixation stimuli for visual field testing and therapy |
US20080077437A1 (en) * | 2006-07-25 | 2008-03-27 | Novavision, Inc. | Process and Method for Providing Incentives to Increase Vision-Therapy Performance |
US20080043201A1 (en) * | 2006-07-25 | 2008-02-21 | Novavision, Inc. | Dynamic fixation stimuli for visual field testing and therapy |
US7753526B2 (en) | 2006-07-25 | 2010-07-13 | Novavision, Inc. | Frequency doubling fixation stimuli for visual field testing and therapy |
US20100292999A1 (en) * | 2006-08-15 | 2010-11-18 | Dinesh Verma | Ophthalmic diagnostic apparatus |
US8764192B2 (en) | 2006-11-17 | 2014-07-01 | Carl Zeiss Meditec Ag | Ophthalmological examination device |
DE102006054774A1 (en) * | 2006-11-17 | 2008-05-21 | Carl Zeiss Meditec Ag | Ophthalmological examination device |
US20080177352A1 (en) * | 2007-01-22 | 2008-07-24 | Novavision, Inc. | Device for Treating Human Vision Using Combined Optical and Electrical Stimulation |
US20100216104A1 (en) * | 2007-04-13 | 2010-08-26 | Reichow Alan W | Vision Cognition And Coordination Testing And Training |
US10226171B2 (en) * | 2007-04-13 | 2019-03-12 | Nike, Inc. | Vision cognition and coordination testing and training |
US20110205167A1 (en) * | 2007-06-13 | 2011-08-25 | Massengill Family Trust | Brain concussion screening method & apparatus |
US20080309616A1 (en) * | 2007-06-13 | 2008-12-18 | Massengill R Kemp | Alertness testing method and apparatus |
US10155148B2 (en) | 2008-05-08 | 2018-12-18 | Nike, Inc. | Vision and cognition testing and/or training under stress conditions |
US20110261049A1 (en) * | 2008-06-20 | 2011-10-27 | Business Intelligence Solutions Safe B.V. | Methods, apparatus and systems for data visualization and related applications |
US9870629B2 (en) * | 2008-06-20 | 2018-01-16 | New Bis Safe Luxco S.À R.L | Methods, apparatus and systems for data visualization and related applications |
US20100156408A1 (en) * | 2008-12-22 | 2010-06-24 | Intercept Logic, Inc. | DC magnetic field interceptor apparatus and method |
US20120092618A1 (en) * | 2009-07-09 | 2012-04-19 | Nike, Inc. | Eye And Body Movement Tracking For Testing And/Or Training |
US20110007275A1 (en) * | 2009-07-09 | 2011-01-13 | Nike, Inc. | Eye and body movement tracking for testing and/or training |
US8100532B2 (en) * | 2009-07-09 | 2012-01-24 | Nike, Inc. | Eye and body movement tracking for testing and/or training |
US8696126B2 (en) * | 2009-07-09 | 2014-04-15 | Nike, Inc. | Eye and body movement tracking for testing and/or training |
EP2371269A1 (en) * | 2010-03-29 | 2011-10-05 | Kowa Co. Ltd. | Perimeter and method of controlling perimeter |
WO2011123312A1 (en) * | 2010-03-31 | 2011-10-06 | Reichert, Inc. | Ophthalmic diagnostic instrument and method |
US9320430B2 (en) | 2010-03-31 | 2016-04-26 | Reichert, Inc. | Ophthalmic diagnostic instrument and method |
US20130027665A1 (en) * | 2010-04-09 | 2013-01-31 | E(Ye) Brain | Optical system for following ocular movements and associated support device |
US9089286B2 (en) * | 2010-04-09 | 2015-07-28 | E(Ye)Brain | Optical system for following ocular movements and associated support device |
FR2964755A1 (en) * | 2010-09-13 | 2012-03-16 | Daniel Ait-Yahiathene | Device for improving vision of eye of human being, has projecting units projecting image in form of image light beam, optical units forming image of scene, and connecting units that connect optical deflector to orbit of eye |
US10463248B2 (en) | 2011-03-02 | 2019-11-05 | Brien Holden Vision Institute Limited | Systems, methods, and devices for measuring eye movement and pupil response |
WO2012120164A1 (en) * | 2011-03-04 | 2012-09-13 | Davalor Consultoria Estrategica Y Tecnológia, S.L. | Device and method for investigating, diagnosing, or helping to diagnose, and treating functional vision problems |
ES2387782A1 (en) * | 2011-03-04 | 2012-10-01 | Davalor Consultoria Estrategica Y Tecnologica S.L. | Equipment and method for examining, diagnosing or aiding the diagnosis, and therapy of functional vision problems |
US8385685B2 (en) * | 2011-06-08 | 2013-02-26 | Honeywell International Inc. | System and method for ocular recognition |
US9076368B2 (en) | 2012-02-06 | 2015-07-07 | Battelle Memorial Institute | Image generation systems and image generation methods |
US8982014B2 (en) | 2012-02-06 | 2015-03-17 | Battelle Memorial Institute | Image generation systems and image generation methods |
US20130209977A1 (en) * | 2012-02-09 | 2013-08-15 | Anthrotronix, Inc. | Performance Assessment Tool |
CN103300966A (en) * | 2012-03-12 | 2013-09-18 | 丹尼尔·阿塔 | Instrument for improving eyesight of patient with age-related macular degeneration |
CN103300966B (en) * | 2012-03-12 | 2015-09-23 | 丹尼尔·阿塔 | A kind of apparatus improving senile degeneration of macula patient vision |
US20130314669A1 (en) * | 2012-05-24 | 2013-11-28 | Hadasit Medical Research Services And Development Ltd. | Method and system for assessing visual disorder |
US8950864B1 (en) | 2013-08-30 | 2015-02-10 | Mednovus, Inc. | Brain dysfunction testing |
US10409079B2 (en) | 2014-01-06 | 2019-09-10 | Avegant Corp. | Apparatus, system, and method for displaying an image using a plate |
US10303242B2 (en) | 2014-01-06 | 2019-05-28 | Avegant Corp. | Media chair apparatus, system, and method |
WO2015120438A1 (en) * | 2014-02-10 | 2015-08-13 | Brien Holden Vision Diagnostics | Systems, methods, and devices for measuring eye movement and pupil response |
US9895057B2 (en) | 2014-04-24 | 2018-02-20 | Carl Zeiss Meditec, Inc. | Functional vision testing using light field displays |
US10299674B2 (en) | 2014-09-22 | 2019-05-28 | Carl Zeiss Meditec Ag | Visual field measuring device and system |
US10527850B2 (en) | 2015-03-16 | 2020-01-07 | Magic Leap, Inc. | Augmented and virtual reality display systems and methods for determining optical prescriptions by imaging retina |
US10379351B2 (en) | 2015-03-16 | 2019-08-13 | Magic Leap, Inc. | Methods and systems for diagnosing and treating eyes using light therapy |
US11747627B2 (en) | 2015-03-16 | 2023-09-05 | Magic Leap, Inc. | Augmented and virtual reality display systems and methods for diagnosing health conditions based on visual fields |
US11474359B2 (en) | 2015-03-16 | 2022-10-18 | Magic Leap, Inc. | Augmented and virtual reality display systems and methods for diagnosing health conditions based on visual fields |
US11256096B2 (en) | 2015-03-16 | 2022-02-22 | Magic Leap, Inc. | Methods and systems for diagnosing and treating presbyopia |
US20170007450A1 (en) | 2015-03-16 | 2017-01-12 | Magic Leap, Inc. | Augmented and virtual reality display systems and methods for delivery of medication to eyes |
US20170007843A1 (en) | 2015-03-16 | 2017-01-12 | Magic Leap, Inc. | Methods and systems for diagnosing and treating eyes using laser therapy |
US10345590B2 (en) | 2015-03-16 | 2019-07-09 | Magic Leap, Inc. | Augmented and virtual reality display systems and methods for determining optical prescriptions |
US10345592B2 (en) | 2015-03-16 | 2019-07-09 | Magic Leap, Inc. | Augmented and virtual reality display systems and methods for diagnosing a user using electrical potentials |
US10345591B2 (en) | 2015-03-16 | 2019-07-09 | Magic Leap, Inc. | Methods and systems for performing retinoscopy |
US10345593B2 (en) | 2015-03-16 | 2019-07-09 | Magic Leap, Inc. | Methods and systems for providing augmented reality content for treating color blindness |
US10359631B2 (en) | 2015-03-16 | 2019-07-23 | Magic Leap, Inc. | Augmented reality display systems and methods for re-rendering the world |
US10365488B2 (en) | 2015-03-16 | 2019-07-30 | Magic Leap, Inc. | Methods and systems for diagnosing eyes using aberrometer |
US10371949B2 (en) | 2015-03-16 | 2019-08-06 | Magic Leap, Inc. | Methods and systems for performing confocal microscopy |
US10371946B2 (en) | 2015-03-16 | 2019-08-06 | Magic Leap, Inc. | Methods and systems for diagnosing binocular vision conditions |
US10371947B2 (en) | 2015-03-16 | 2019-08-06 | Magic Leap, Inc. | Methods and systems for modifying eye convergence for diagnosing and treating conditions including strabismus and/or amblyopia |
US10371948B2 (en) * | 2015-03-16 | 2019-08-06 | Magic Leap, Inc. | Methods and systems for diagnosing color blindness |
US10371945B2 (en) | 2015-03-16 | 2019-08-06 | Magic Leap, Inc. | Methods and systems for diagnosing and treating higher order refractive aberrations of an eye |
US10379353B2 (en) | 2015-03-16 | 2019-08-13 | Magic Leap, Inc. | Augmented and virtual reality display systems and methods for diagnosing health conditions based on visual fields |
US10379354B2 (en) | 2015-03-16 | 2019-08-13 | Magic Leap, Inc. | Methods and systems for diagnosing contrast sensitivity |
US10379350B2 (en) | 2015-03-16 | 2019-08-13 | Magic Leap, Inc. | Methods and systems for diagnosing eyes using ultrasound |
US10775628B2 (en) | 2015-03-16 | 2020-09-15 | Magic Leap, Inc. | Methods and systems for diagnosing and treating presbyopia |
US10386641B2 (en) | 2015-03-16 | 2019-08-20 | Magic Leap, Inc. | Methods and systems for providing augmented reality content for treatment of macular degeneration |
US10386639B2 (en) | 2015-03-16 | 2019-08-20 | Magic Leap, Inc. | Methods and systems for diagnosing eye conditions such as red reflex using light reflected from the eyes |
US10386640B2 (en) | 2015-03-16 | 2019-08-20 | Magic Leap, Inc. | Methods and systems for determining intraocular pressure |
US20170000330A1 (en) * | 2015-03-16 | 2017-01-05 | Magic Leap, Inc. | Methods and systems for diagnosing color blindness |
US10429649B2 (en) | 2015-03-16 | 2019-10-01 | Magic Leap, Inc. | Augmented and virtual reality display systems and methods for diagnosing using occluder |
US10437062B2 (en) | 2015-03-16 | 2019-10-08 | Magic Leap, Inc. | Augmented and virtual reality display platforms and methods for delivering health treatments to a user |
US10444504B2 (en) | 2015-03-16 | 2019-10-15 | Magic Leap, Inc. | Methods and systems for performing optical coherence tomography |
US10451877B2 (en) | 2015-03-16 | 2019-10-22 | Magic Leap, Inc. | Methods and systems for diagnosing and treating presbyopia |
US10459229B2 (en) | 2015-03-16 | 2019-10-29 | Magic Leap, Inc. | Methods and systems for performing two-photon microscopy |
US11156835B2 (en) | 2015-03-16 | 2021-10-26 | Magic Leap, Inc. | Methods and systems for diagnosing and treating health ailments |
US20170000342A1 (en) | 2015-03-16 | 2017-01-05 | Magic Leap, Inc. | Methods and systems for detecting health conditions by imaging portions of the eye, including the fundus |
US10466477B2 (en) | 2015-03-16 | 2019-11-05 | Magic Leap, Inc. | Methods and systems for providing wavefront corrections for treating conditions including myopia, hyperopia, and/or astigmatism |
US10473934B2 (en) | 2015-03-16 | 2019-11-12 | Magic Leap, Inc. | Methods and systems for performing slit lamp examination |
US10983351B2 (en) | 2015-03-16 | 2021-04-20 | Magic Leap, Inc. | Augmented and virtual reality display systems and methods for diagnosing health conditions based on visual fields |
US10969588B2 (en) | 2015-03-16 | 2021-04-06 | Magic Leap, Inc. | Methods and systems for diagnosing contrast sensitivity |
US10788675B2 (en) | 2015-03-16 | 2020-09-29 | Magic Leap, Inc. | Methods and systems for diagnosing and treating eyes using light therapy |
US10539795B2 (en) | 2015-03-16 | 2020-01-21 | Magic Leap, Inc. | Methods and systems for diagnosing and treating eyes using laser therapy |
US10539794B2 (en) | 2015-03-16 | 2020-01-21 | Magic Leap, Inc. | Methods and systems for detecting health conditions by imaging portions of the eye, including the fundus |
US10545341B2 (en) | 2015-03-16 | 2020-01-28 | Magic Leap, Inc. | Methods and systems for diagnosing eye conditions, including macular degeneration |
US10564423B2 (en) | 2015-03-16 | 2020-02-18 | Magic Leap, Inc. | Augmented and virtual reality display systems and methods for delivery of medication to eyes |
US20160291326A1 (en) * | 2015-04-02 | 2016-10-06 | Avegant Corporation | System, apparatus, and method for displaying an image with a wider field of view |
US9823474B2 (en) * | 2015-04-02 | 2017-11-21 | Avegant Corp. | System, apparatus, and method for displaying an image with a wider field of view |
US9995857B2 (en) | 2015-04-03 | 2018-06-12 | Avegant Corp. | System, apparatus, and method for displaying an image using focal modulation |
US10514553B2 (en) | 2015-06-30 | 2019-12-24 | 3M Innovative Properties Company | Polarizing beam splitting system |
US11693243B2 (en) | 2015-06-30 | 2023-07-04 | 3M Innovative Properties Company | Polarizing beam splitting system |
US11061233B2 (en) | 2015-06-30 | 2021-07-13 | 3M Innovative Properties Company | Polarizing beam splitter and illuminator including same |
US10568502B2 (en) | 2016-03-23 | 2020-02-25 | The Chinese University Of Hong Kong | Visual disability detection system using virtual reality |
US10459231B2 (en) | 2016-04-08 | 2019-10-29 | Magic Leap, Inc. | Augmented reality systems and methods with variable focus lens elements |
US11106041B2 (en) | 2016-04-08 | 2021-08-31 | Magic Leap, Inc. | Augmented reality systems and methods with variable focus lens elements |
US11614626B2 (en) | 2016-04-08 | 2023-03-28 | Magic Leap, Inc. | Augmented reality systems and methods with variable focus lens elements |
US10888222B2 (en) | 2016-04-22 | 2021-01-12 | Carl Zeiss Meditec, Inc. | System and method for visual field testing |
US11129527B2 (en) | 2016-06-09 | 2021-09-28 | Qd Laser, Inc. | Visual field/visual acuity examination system, visual field/visual acuity examination device, visual field/visual acuity examination method, visual field/visual acuity examination program, and server device |
CN109310315A (en) * | 2016-06-09 | 2019-02-05 | Qd激光公司 | Visual field visual acuity test system, visual field equipment for examining vision, visual field eyesight exam method, visual field eye test program and server unit |
CN109310315B (en) * | 2016-06-09 | 2022-02-22 | Qd激光公司 | Visual field visual acuity test system, visual field visual acuity test device, visual field visual acuity test method, storage medium, and server device |
WO2018025125A1 (en) * | 2016-07-31 | 2018-02-08 | Ic Inside Ltd. | Method of retinal sensitivity mapping using near-eye display |
US11931103B2 (en) | 2017-01-05 | 2024-03-19 | Heidelberg Engineering Gmbh | Method and device for carrying out the method in a vehicle |
US10962855B2 (en) | 2017-02-23 | 2021-03-30 | Magic Leap, Inc. | Display system with variable power reflector |
US11774823B2 (en) | 2017-02-23 | 2023-10-03 | Magic Leap, Inc. | Display system with variable power reflector |
US11300844B2 (en) | 2017-02-23 | 2022-04-12 | Magic Leap, Inc. | Display system with variable power reflector |
WO2020010008A1 (en) * | 2018-07-03 | 2020-01-09 | Tarseer, Inc. | Methods and systems for vision monitoring |
US11478143B2 (en) | 2018-09-21 | 2022-10-25 | MacuLogix, Inc. | Methods, apparatus, and systems for ophthalmic testing and measurement |
US11471044B2 (en) | 2018-09-21 | 2022-10-18 | MacuLogix, Inc. | Methods, apparatus, and systems for ophthalmic testing and measurement |
US10667683B2 (en) | 2018-09-21 | 2020-06-02 | MacuLogix, Inc. | Methods, apparatus, and systems for ophthalmic testing and measurement |
US11478142B2 (en) | 2018-09-21 | 2022-10-25 | MacuLogix, Inc. | Methods, apparatus, and systems for ophthalmic testing and measurement |
US11457805B2 (en) | 2018-09-21 | 2022-10-04 | MacuLogix, Inc. | Methods, apparatus, and systems for ophthalmic testing and measurement |
US11344194B2 (en) | 2018-09-21 | 2022-05-31 | MacuLogix, Inc. | Methods, apparatus, and systems for ophthalmic testing and measurement |
US11089954B2 (en) | 2018-09-21 | 2021-08-17 | MacuLogix, Inc. | Method and apparatus for guiding a test subject through an ophthalmic test |
US11768594B2 (en) | 2019-11-29 | 2023-09-26 | Electric Puppets Incorporated | System and method for virtual reality based human biological metrics collection and stimulus presentation |
WO2021102577A1 (en) * | 2019-11-29 | 2021-06-03 | Electric Puppets Incorporated | System and method for virtual reality based human biological metrics collection and stimulus presentation |
US20210378504A1 (en) * | 2020-06-04 | 2021-12-09 | Sony Interactive Entertainment Inc. | Gaze tracking apparatus and systems |
US11925412B2 (en) * | 2020-06-04 | 2024-03-12 | Sony Interactive Entertainment Inc. | Gaze tracking apparatus and systems |
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