US6327329B1 - Methods and apparatus for monitoring detector image quality - Google Patents

Methods and apparatus for monitoring detector image quality Download PDF

Info

Publication number
US6327329B1
US6327329B1 US09/140,110 US14011098A US6327329B1 US 6327329 B1 US6327329 B1 US 6327329B1 US 14011098 A US14011098 A US 14011098A US 6327329 B1 US6327329 B1 US 6327329B1
Authority
US
United States
Prior art keywords
detector
cell
accordance
data
scan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US09/140,110
Inventor
Neil B. Bromberg
Hui David He
Mary Sue Kulpins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Electric Co
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Electric Co filed Critical General Electric Co
Priority to US09/140,110 priority Critical patent/US6327329B1/en
Assigned to GENERAL ELECTRIC COMPANY reassignment GENERAL ELECTRIC COMPANY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BROMBERG, NEIL B., HE, HUI DAVID, KULPINS, MARY SUE
Priority to IL13140299A priority patent/IL131402A/en
Priority to JP23222899A priority patent/JP4782905B2/en
Priority to EP99306635A priority patent/EP0982683A3/en
Application granted granted Critical
Publication of US6327329B1 publication Critical patent/US6327329B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/02Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material
    • G01N23/04Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material
    • G01N23/046Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material using tomography, e.g. computed tomography [CT]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00Investigating materials by wave or particle radiation
    • G01N2223/40Imaging
    • G01N2223/419Imaging computed tomograph

Definitions

  • This invention relates generally to imaging and, more particularly, to monitoring performance of a detector in an imaging system.
  • an x-ray source projects a fan-shaped beam which is collimated to lie within an X-Y plane of a Cartesian coordinate system and generally referred to as the “imaging plane”.
  • the x-ray beam passes through the object being imaged, such as a patient.
  • the beam after being attenuated by the object, impinges upon an array of radiation detectors.
  • the intensity of the attenuated beam radiation received at the detector array is dependent upon the attenuation of the x-ray beam by the object.
  • Each detector element of the array produces a separate electrical signal that is a measurement of the beam attenuation at the detector location.
  • the attenuation measurements from all the detectors are acquired separately to produce a transmission profile.
  • X-ray sources typically include x-ray tubes, which emit the x-ray beam at a focal spot.
  • X-ray detectors typically include a post patient collimator for collimating scattered x-ray beams received at the detector.
  • a scintillator is located adjacent the post patient collimator, and photodiodes are positioned adjacent the scintillator.
  • Multislice CT systems are used to obtain data for an increased number of slices during a scan.
  • Known multislice systems typically include detectors generally known as 3-D detectors. With such 3-D detectors, a plurality of detector elements form separate channels arranged in columns and rows. Each row of detectors forms a separate slice. For example, a two slice detector has two rows of detector elements, and a four slice detector has four rows of detector elements.
  • a multislice scan multiple rows of detector cells are simultaneously impinged by the x-ray beam, and therefore data for several slices is obtained.
  • the channels of the detector typically are ganged together to form the rows.
  • Channel to channel variation in the z-direction can result in generation of image artifacts.
  • the gain variation changes due to radiation damage. Corrections for such channel to channel variability are know, but the effectiveness of such corrections depend on the magnitude of the variability.
  • an algorithm which may be executed periodically by the imaging system, for detecting cell to cell variation to ensure that the maximum allowable channel to channel variation is not exceeded. More specifically, and in accordance with one aspect of the present invention, an algorithm is periodically executed to measure the relative gains in the channels.
  • the gains are measured, for example, by recording the signal from an air scan and normalizing to a common reference. Part of the normalization process includes accounting for the non uniformity of the x-ray beam, for example, the heel effect. It is assumed that the x-ray flux profile in z is slowly changing in the x-direction and is obtained by low pass filtering in x.
  • the normalized values are then compared to a predetermined specification. If any particular cell is not within the specification parameters, then the module in which such cell resides may be replaced.
  • a trending analysis In addition to measuring gain variation and comparing it to a specification, a trending analysis also may be performed.
  • the trending algorithm predicts the time at which the detector will fail the specification so that replacement of the detector may take place before failure occurs.
  • FIG. 1 is a pictorial view of a CT imaging system.
  • FIG. 2 is a block schematic diagram of the system illustrated in FIG. 1 .
  • FIG. 3 is a perspective view of a CT system detector array.
  • FIG. 4 is a perspective view of a detector module.
  • FIG. 5 is a schematic view of the CT imaging system shown in FIG. 1 .
  • the detector described below includes a plurality of modules and each module includes a plurality of detector cells.
  • a detector which has multiple modules with multiple elements along the x-axis and/or z-axis joined together in either direction to acquire multislice scan data simultaneously can be utilized.
  • the system is operable in a multislice mode to collect 1 or more slices of data.
  • Axial and helical scans can be performed with the system, and cross section images of a scanned object can be processed, reconstructed, displayed and/or archived.
  • a computed tomography (CT) imaging system 10 is shown as including a gantry 12 representative of a “third generation” CT scanner.
  • Gantry 12 has an x-ray source 14 that projects a beam of x-rays 16 toward a detector array 18 on the opposite side of gantry 12 .
  • Detector array 18 is formed by detector elements 20 which together sense the projected x-rays that pass through a medical patient 22 .
  • Each detector element 20 produces an electrical signal that represents the intensity of an impinging x-ray beam and hence the attenuation of the beam as it passes through patient 22 .
  • gantry 12 and the components mounted thereon rotate about a center of rotation 24 .
  • Control mechanism 26 includes an x-ray controller 28 that provides power and timing signals to x-ray source 14 and a gantry motor controller 30 that controls the rotational speed and position of gantry 12 .
  • a data acquisition system (DAS) 32 in control mechanism 26 samples analog data from detector elements 20 and converts the data to digital signals for subsequent processing.
  • An image reconstructor 34 receives sampled and digitized x-ray data from DAS 32 and performs high speed image reconstruction. The reconstructed image is applied as an input to a computer 36 which stores the image in a mass storage device 38 .
  • DAS data acquisition system
  • Computer 36 also receives and supplies signals via a user interface, or graphical user interface (GUI). Specifically, computer receives commands and scanning parameters from an operator via console 40 that has a keyboard and a mouse (not shown). An associated cathode ray tube display 42 allows the operator to observe the reconstructed image and other data from computer 36 . The operator supplied commands and parameters are used by computer 36 to provide control signals and information to x-ray controller 28 , gantry motor controller 30 , DAS 32 , and table motor controller 44 .
  • GUI graphical user interface
  • detector array 18 includes a plurality of detector modules 58 .
  • Each detector module 58 is secured to a detector housing 60 .
  • Each module 58 includes a multidimensional scintillator array 62 and a high density semiconductor array (not visible).
  • a post patient collimator (not shown) is positioned over and adjacent scintillator array 62 to collimate x-ray beams before such beams impinge upon scintillator array 62 .
  • Scintillator array 62 includes a plurality of scintillation elements arranged in an array, and the semiconductor array includes a plurality of photodiodes (not visible) arranged in an identical array. The photodiodes are deposited, or formed on a substrate 64 , and scintillator array 62 is positioned over and secured to substrate 64 .
  • Detector module 58 also includes a switch apparatus 66 electrically coupled to a decoder 68 .
  • Switch apparatus 66 is a multidimensional semiconductor switch array of similar size as the photodiode array.
  • switch apparatus 66 includes an array of field effect transistors (not shown) with each field effect transistor (FET) having an input, an output, and a control line (not shown).
  • Switch apparatus 66 is coupled between the photodiode array and DAS 32 .
  • each switch apparatus FET input is electrically connected to a photodiode array output and each switch apparatus FET output is electrically connected to DAS 32 , for example, using flexible electrical cable 70 .
  • Decoder 68 controls the operation of switch apparatus 66 to enable, disable, or combine the outputs of the photodiode array in accordance with a desired number of slices and slice resolutions for each slice.
  • Decoder 68 in one embodiment, is a decoder chip or a FET controller as known in the art. Decoder 68 includes a plurality of output and control lines coupled to switch apparatus 66 and computer 36 . Particularly, the decoder outputs are electrically connected to the switch apparatus control lines to enable switch apparatus 66 to transmit the proper data from the switch apparatus inputs to the switch apparatus outputs. The decoder control lines are electrically connected to the switch apparatus control lines and determine which of the decoder outputs will be enabled.
  • decoder 68 Utilizing decoder 68 , specific FETs within switch apparatus 66 are enabled, disabled, or combined so that specific outputs of the photodiode array are electrically connected to CT system DAS 32 .
  • decoder 68 enables switch apparatus 66 so that all rows of the photodiode array are electrically connected to DAS 32 , resulting in 16 separate, simultaneous slices of data being sent to DAS 32 .
  • many other slice combinations are possible.
  • detector 18 includes fifty-seven detector modules 58 .
  • the semiconductor array and scintillator array 62 each have an array size of 16 ⁇ 16.
  • detector 18 has 16 rows and 912 columns (16 ⁇ 57 modules), which enables 16 simultaneous slices of data to be collected with each rotation of gantry 12 .
  • the present invention is not limited to any specific array size, and it is contemplated that the array can be larger or smaller depending upon the specific operator needs.
  • detector 18 may be operated in many different slice thickness and number modes, e.g., one, two, and four slice modes.
  • the FETs can be configured in the four slice mode, so that data is collected for four slices from one or more rows of the photodiode array.
  • various combinations of outputs of the photodiode array can be enabled, disabled, or combined so that the slice thickness may, for example, be 1.25 mm, 2.5 mm, 3.75 mm, or 5 mm. Additional examples include a single slice mode including one slice with slices ranging from 1.25 mm thick to 20 mm thick, and a two slice mode including two slices with slices ranging from 1.25 mm thick to 10 mm thick. Additional modes beyond those described are possible.
  • FIG. 5 is a simplified schematic view of a “four (or quad) slice” system in that four rows 102 , 104 , 106 and 108 of detector cells are utilized to obtain projection data.
  • Detector cells 110 , 112 , 114 and 116 form rows 102 , 103 , 106 and 108 .
  • Each detector cell 110 , 112 , 114 , and 116 illustrated in FIG. 5 may actually be composed of a number of cells (e.g., four) ganged together to produce one output which is supplied to DAS 32 .
  • collimator 92 includes eccentric cams 120 A and 120 B.
  • the position of cams 120 A and 120 B are controlled by x-ray controller 28 .
  • Cams 120 A and 120 B are positioned on opposing sides of fan beam plane 94 and may be independently adjusted with respect to the spacing between cams 120 A and 120 B and their location relative to fan beam plane 94 .
  • Cams 120 A and 120 B may be positioned with a single cam drive, or alternatively, each cam may be positioned with a separate cam drive, for example a motor.
  • Cams 120 A and 120 B are fabricated from an x-ray absorbing material, for example, tungsten.
  • cams 120 A and 120 B alter the rotation of respective cams 120 A and 120 B alters the z-axis profile of x-ray beam 16 . More specifically, altering position of cams 120 A and 120 B alters the position and width of x-ray beam umbra. Particularly, as a result of the jointly stepping eccentric shape of cams 120 A and 120 B, the total width of x-ray beam umbra is altered. Altering the position, or stepping, cam 120 A, alone, alters the umbra width and position relative to one edge of detector array 18 . Altering the position of cam 120 B, alone, alters the umbra width and position relative to the other, or second edge, of detector array 18 so that the x-ray dosage received by patient 22 is reduced.
  • x-ray source 14 is fixed, or placed in a stationary position, and respective cams 120 A and 120 B are placed in nominal positions so that an x-ray beam 16 is radiated through collimator 92 toward detector array 18 .
  • Data is then collected from detector array 18 for a series of steps, or positions of respective cam 120 A and 120 B.
  • aperture of collimator 92 particularly adjusting cams 120 A and 120 B, an optimal x-ray beam is radiated onto detector array 18 to produce proper signal intensities from cells 110 , 112 , 114 and 116 .
  • an algorithm is periodically executed to measure the relative gains in the channels. These gains are measured by recording the signal from an air scan and normalizing to a common reference. Part of the normalization process includes accounting for the non uniformity of the x-ray beam, for example, the heel effect. It is assumed that the x-ray flux profile in z is slowly changing in the x-direction and is obtained by low pass filtering in x. The normalized values are then compared to a predetermined specification. If any particular cell is not within the specification parameters, then the module in which such cell resides may be replaced.
  • a z-slope correction on the collected data is performed. Specifically, and starting from individual cell measurements obtained via air-scan and view averaging, after offset subtraction and reference channel normalization:
  • Nominal gains are required in modeling slow “x” variations that by themselves do not lead to slope related artifacts in the image, but if not accounted for in the correction process, can lead to instabilities.
  • Three examples are (1) twin nominal gain profile, at the scintillator edge, (2) x-ray beam z-profile due to the heel effect, and (3) partial illumination condition, as induced by the use of the beam penumbra for a contemplated low dose mode of operation.
  • the elements of G fall within a range of numbers which are close to 1. The exact boundaries of the range are determined empirically.
  • a trending analysis In addition to measuring gain variation and comparing it to a specification, a trending analysis also may be performed.
  • the trending algorithm predicts the time at which the detector will fail the specification so that replacement of the detector may take place before failure occurs.
  • the trending algorithm assumes a pattern of usage which is constant in time and for the specific detector in use the aging of the detector elements occur in a linear fashion. A least squares fit to a linear model is made to each element of the gain matrix as a function of time. In general the nature of the trending algorithm depends on the aging characteristics of the detector material.
  • the data can be remotely retrieved and analyzed from the multislice scanner, e.g., from an automated support center.
  • the data may be retrieved using a PPP modem connection over the phone lines.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

Methods and apparatus for detecting cell to cell variation to ensure that the maximum allowable channel to channel variation is not exceeded are described. In one embodiment, an algorithm is periodically executed to measure the relative gains in the channels. The gains are measured, for example, by recording the signal from an air scan and normalizing to a common reference. Part of the normalization process includes accounting for the non uniformity of the x-ray beam, for example, the heel effect. It is assumed that the x-ray flux profile in z is slowly changing in the x-direction and is obtained by low pass filtering in x. The normalized values are then compared to a predetermined specification. If any particular cell is not within the specification parameters, then the module in which such cell resides may be replaced. In addition to measuring gain variation and comparing it to a specification, a trending analysis also may be performed. The trending algorithm predicts the time at which the detector will fail the specification so that replacement of the detector may take place before failure occurs.

Description

BACKGROUND OF THE INVENTION
This invention relates generally to imaging and, more particularly, to monitoring performance of a detector in an imaging system.
In at least some known medical imaging systems, such as a computed tomograph (CT) imaging system, an x-ray source projects a fan-shaped beam which is collimated to lie within an X-Y plane of a Cartesian coordinate system and generally referred to as the “imaging plane”. The x-ray beam passes through the object being imaged, such as a patient. The beam, after being attenuated by the object, impinges upon an array of radiation detectors. The intensity of the attenuated beam radiation received at the detector array is dependent upon the attenuation of the x-ray beam by the object. Each detector element of the array produces a separate electrical signal that is a measurement of the beam attenuation at the detector location. The attenuation measurements from all the detectors are acquired separately to produce a transmission profile.
In known third generation CT systems, the x-ray source and the detector array are rotated with a gantry within the imaging plane and around the object to be imaged so that the angle at which the x-ray beam intersects the object constantly changes. X-ray sources typically include x-ray tubes, which emit the x-ray beam at a focal spot. X-ray detectors typically include a post patient collimator for collimating scattered x-ray beams received at the detector. A scintillator is located adjacent the post patient collimator, and photodiodes are positioned adjacent the scintillator.
Multislice CT systems are used to obtain data for an increased number of slices during a scan. Known multislice systems typically include detectors generally known as 3-D detectors. With such 3-D detectors, a plurality of detector elements form separate channels arranged in columns and rows. Each row of detectors forms a separate slice. For example, a two slice detector has two rows of detector elements, and a four slice detector has four rows of detector elements. During a multislice scan, multiple rows of detector cells are simultaneously impinged by the x-ray beam, and therefore data for several slices is obtained.
The channels of the detector typically are ganged together to form the rows. Channel to channel variation in the z-direction can result in generation of image artifacts. As the detector ages the gain variation changes due to radiation damage. Corrections for such channel to channel variability are know, but the effectiveness of such corrections depend on the magnitude of the variability.
BRIEF SUMMARY OF THE INVENTION
These and other objects may be attained by an algorithm, which may be executed periodically by the imaging system, for detecting cell to cell variation to ensure that the maximum allowable channel to channel variation is not exceeded. More specifically, and in accordance with one aspect of the present invention, an algorithm is periodically executed to measure the relative gains in the channels. The gains are measured, for example, by recording the signal from an air scan and normalizing to a common reference. Part of the normalization process includes accounting for the non uniformity of the x-ray beam, for example, the heel effect. It is assumed that the x-ray flux profile in z is slowly changing in the x-direction and is obtained by low pass filtering in x. The normalized values are then compared to a predetermined specification. If any particular cell is not within the specification parameters, then the module in which such cell resides may be replaced.
In addition to measuring gain variation and comparing it to a specification, a trending analysis also may be performed. The trending algorithm predicts the time at which the detector will fail the specification so that replacement of the detector may take place before failure occurs.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a pictorial view of a CT imaging system.
FIG. 2 is a block schematic diagram of the system illustrated in FIG. 1.
FIG. 3 is a perspective view of a CT system detector array.
FIG. 4 is a perspective view of a detector module.
FIG. 5 is a schematic view of the CT imaging system shown in FIG. 1.
DETAILED DESCRIPTION OF THE INVENTION
Set forth below is a description of an exemplary multislice CT system in accordance with one embodiment of the present invention. Although one embodiment of the system is described in detail below, it should be understood that many alternative embodiments of the inventions are possible. For example, although one particular detector is described, the present invention could be utilized in connection with other detectors, and the present invention is not limited to practice with any one particular type of multislice detector. Specifically, the detector described below includes a plurality of modules and each module includes a plurality of detector cells. Rather than the specific detector described below, a detector which has multiple modules with multiple elements along the x-axis and/or z-axis joined together in either direction to acquire multislice scan data simultaneously, can be utilized. Generally, the system is operable in a multislice mode to collect 1 or more slices of data. Axial and helical scans can be performed with the system, and cross section images of a scanned object can be processed, reconstructed, displayed and/or archived.
Referring to FIGS. 1 and 2, a computed tomography (CT) imaging system 10 is shown as including a gantry 12 representative of a “third generation” CT scanner. Gantry 12 has an x-ray source 14 that projects a beam of x-rays 16 toward a detector array 18 on the opposite side of gantry 12. Detector array 18 is formed by detector elements 20 which together sense the projected x-rays that pass through a medical patient 22. Each detector element 20 produces an electrical signal that represents the intensity of an impinging x-ray beam and hence the attenuation of the beam as it passes through patient 22. During a scan to acquire x-ray projection data, gantry 12 and the components mounted thereon rotate about a center of rotation 24.
Rotation of gantry 12 and the operation of x-ray source 14 are governed by a control mechanism 26 of CT system 10. Control mechanism 26 includes an x-ray controller 28 that provides power and timing signals to x-ray source 14 and a gantry motor controller 30 that controls the rotational speed and position of gantry 12. A data acquisition system (DAS) 32 in control mechanism 26 samples analog data from detector elements 20 and converts the data to digital signals for subsequent processing. An image reconstructor 34 receives sampled and digitized x-ray data from DAS 32 and performs high speed image reconstruction. The reconstructed image is applied as an input to a computer 36 which stores the image in a mass storage device 38.
Computer 36 also receives and supplies signals via a user interface, or graphical user interface (GUI). Specifically, computer receives commands and scanning parameters from an operator via console 40 that has a keyboard and a mouse (not shown). An associated cathode ray tube display 42 allows the operator to observe the reconstructed image and other data from computer 36. The operator supplied commands and parameters are used by computer 36 to provide control signals and information to x-ray controller 28, gantry motor controller 30, DAS 32, and table motor controller 44.
As shown in FIGS. 3 and 4, detector array 18 includes a plurality of detector modules 58. Each detector module 58 is secured to a detector housing 60. Each module 58 includes a multidimensional scintillator array 62 and a high density semiconductor array (not visible). A post patient collimator (not shown) is positioned over and adjacent scintillator array 62 to collimate x-ray beams before such beams impinge upon scintillator array 62. Scintillator array 62 includes a plurality of scintillation elements arranged in an array, and the semiconductor array includes a plurality of photodiodes (not visible) arranged in an identical array. The photodiodes are deposited, or formed on a substrate 64, and scintillator array 62 is positioned over and secured to substrate 64.
Detector module 58 also includes a switch apparatus 66 electrically coupled to a decoder 68. Switch apparatus 66 is a multidimensional semiconductor switch array of similar size as the photodiode array. In one embodiment, switch apparatus 66 includes an array of field effect transistors (not shown) with each field effect transistor (FET) having an input, an output, and a control line (not shown). Switch apparatus 66 is coupled between the photodiode array and DAS 32. Particularly, each switch apparatus FET input is electrically connected to a photodiode array output and each switch apparatus FET output is electrically connected to DAS 32, for example, using flexible electrical cable 70.
Decoder 68 controls the operation of switch apparatus 66 to enable, disable, or combine the outputs of the photodiode array in accordance with a desired number of slices and slice resolutions for each slice. Decoder 68, in one embodiment, is a decoder chip or a FET controller as known in the art. Decoder 68 includes a plurality of output and control lines coupled to switch apparatus 66 and computer 36. Particularly, the decoder outputs are electrically connected to the switch apparatus control lines to enable switch apparatus 66 to transmit the proper data from the switch apparatus inputs to the switch apparatus outputs. The decoder control lines are electrically connected to the switch apparatus control lines and determine which of the decoder outputs will be enabled. Utilizing decoder 68, specific FETs within switch apparatus 66 are enabled, disabled, or combined so that specific outputs of the photodiode array are electrically connected to CT system DAS 32. In one embodiment defined as a 16 slice mode, decoder 68 enables switch apparatus 66 so that all rows of the photodiode array are electrically connected to DAS 32, resulting in 16 separate, simultaneous slices of data being sent to DAS 32. Of course, many other slice combinations are possible.
In one specific embodiment, detector 18 includes fifty-seven detector modules 58. The semiconductor array and scintillator array 62 each have an array size of 16×16. As a result, detector 18 has 16 rows and 912 columns (16×57 modules), which enables 16 simultaneous slices of data to be collected with each rotation of gantry 12. Of course, the present invention is not limited to any specific array size, and it is contemplated that the array can be larger or smaller depending upon the specific operator needs. Also, detector 18 may be operated in many different slice thickness and number modes, e.g., one, two, and four slice modes. For example, the FETs can be configured in the four slice mode, so that data is collected for four slices from one or more rows of the photodiode array. Depending upon the specific configuration of the FETs as defined by decoder control lines, various combinations of outputs of the photodiode array can be enabled, disabled, or combined so that the slice thickness may, for example, be 1.25 mm, 2.5 mm, 3.75 mm, or 5 mm. Additional examples include a single slice mode including one slice with slices ranging from 1.25 mm thick to 20 mm thick, and a two slice mode including two slices with slices ranging from 1.25 mm thick to 10 mm thick. Additional modes beyond those described are possible.
FIG. 5 is a simplified schematic view of a “four (or quad) slice” system in that four rows 102, 104, 106 and 108 of detector cells are utilized to obtain projection data. Detector cells 110, 112, 114 and 116 form rows 102, 103, 106 and 108. Each detector cell 110, 112, 114, and 116 illustrated in FIG. 5 may actually be composed of a number of cells (e.g., four) ganged together to produce one output which is supplied to DAS 32.
In one embodiment, collimator 92 includes eccentric cams 120A and 120B. The position of cams 120A and 120B are controlled by x-ray controller 28. Cams 120A and 120B are positioned on opposing sides of fan beam plane 94 and may be independently adjusted with respect to the spacing between cams 120A and 120B and their location relative to fan beam plane 94. Cams 120A and 120B may be positioned with a single cam drive, or alternatively, each cam may be positioned with a separate cam drive, for example a motor. Cams 120A and 120B are fabricated from an x-ray absorbing material, for example, tungsten.
As a result of the eccentric shape, the rotation of respective cams 120A and 120B alters the z-axis profile of x-ray beam 16. More specifically, altering position of cams 120A and 120B alters the position and width of x-ray beam umbra. Particularly, as a result of the jointly stepping eccentric shape of cams 120A and 120B, the total width of x-ray beam umbra is altered. Altering the position, or stepping, cam 120A, alone, alters the umbra width and position relative to one edge of detector array 18. Altering the position of cam 120B, alone, alters the umbra width and position relative to the other, or second edge, of detector array 18 so that the x-ray dosage received by patient 22 is reduced.
In operation, x-ray source 14 is fixed, or placed in a stationary position, and respective cams 120A and 120B are placed in nominal positions so that an x-ray beam 16 is radiated through collimator 92 toward detector array 18. Data is then collected from detector array 18 for a series of steps, or positions of respective cam 120A and 120B. By altering aperture of collimator 92, particularly adjusting cams 120A and 120B, an optimal x-ray beam is radiated onto detector array 18 to produce proper signal intensities from cells 110, 112, 114 and 116.
As explained above, as detector cells 110, 112, 114, and 116 age, the gain variation from channel to channel changes. In order to ensure that the maximum allowable channel to channel variation is not exceeded, and in accordance with one aspect of the present invention, an algorithm is periodically executed to measure the relative gains in the channels. These gains are measured by recording the signal from an air scan and normalizing to a common reference. Part of the normalization process includes accounting for the non uniformity of the x-ray beam, for example, the heel effect. It is assumed that the x-ray flux profile in z is slowly changing in the x-direction and is obtained by low pass filtering in x. The normalized values are then compared to a predetermined specification. If any particular cell is not within the specification parameters, then the module in which such cell resides may be replaced.
In one particular embodiment, a z-slope correction on the collected data is performed. Specifically, and starting from individual cell measurements obtained via air-scan and view averaging, after offset subtraction and reference channel normalization:
{Xl,i}1, . . . ,16; i=1, . . . ,Nchannel.
“x” averages are then defined for the gain: nominal gain profile definition, including normalization to the maximum in the column: where nave is the (odd) number of channels to be used for the nominal gain definition “x” moving bp l ( i ) = 1 nave k = i - ( nave - 1 ) / 2 k = i + ( nave - 1 ) / 2 [ X l , k max 1 l 16 X ; l ]
Figure US06327329-20011204-M00001
Normalization to the maximum in z then leads to the following expression: BP l ( i ) = bp l ( i ) max 1 l 16 bp l ( i )
Figure US06327329-20011204-M00002
The nominal gain can then be defined by: G i , l = G l ( i ) = ( X l , i max 1 l 16 X l , i ) BP l ( i )
Figure US06327329-20011204-M00003
These nominal gain are the inputs for the z-slope correction algorithm.
Nominal gains are required in modeling slow “x” variations that by themselves do not lead to slope related artifacts in the image, but if not accounted for in the correction process, can lead to instabilities. Three examples are (1) twin nominal gain profile, at the scintillator edge, (2) x-ray beam z-profile due to the heel effect, and (3) partial illumination condition, as induced by the use of the beam penumbra for a contemplated low dose mode of operation. The elements of G fall within a range of numbers which are close to 1. The exact boundaries of the range are determined empirically.
In addition to measuring gain variation and comparing it to a specification, a trending analysis also may be performed. The trending algorithm predicts the time at which the detector will fail the specification so that replacement of the detector may take place before failure occurs. The trending algorithm assumes a pattern of usage which is constant in time and for the specific detector in use the aging of the detector elements occur in a linear fashion. A least squares fit to a linear model is made to each element of the gain matrix as a function of time. In general the nature of the trending algorithm depends on the aging characteristics of the detector material.
The data can be remotely retrieved and analyzed from the multislice scanner, e.g., from an automated support center. For example, the data may be retrieved using a PPP modem connection over the phone lines.
From the preceding description of various embodiments of the present invention, it is evident that the objects of the invention are attained. Although the invention has been described and illustrated in detail, it is to be clearly understood that the same is intended by way of illustration and example only and is not to be taken by way of limitation. Accordingly, the spirit and scope of the invention are to be limited only by the terms of the appended claims.

Claims (27)

What is claimed is:
1. A method for monitoring cell to cell variation in a detector of a computed tomography system, the system including an x-ray source for producing an x-ray beam along an imaging plane, the detector including a plurality of detector cells extending in a z-axis and arranged in a plurality of dectector cell modules, said method comprising:
performing an air scan;
obtaining data from the detector cells from the air scan;
comparing the cell data to a specification to determine cells not within parameters of the specification; and
replacing a detector cell module in which a detector cell is not within the specification parameters.
2. A method in accordance with claim 1 wherein performing a scan comprises performing an air scan.
3. A method in accordance with claim 1 wherein prior to comparing the cell data to a specification, said method further comprises normalizing the cell data.
4. A method in accordance with claim 3 wherein normalizing the cell data includes compensating for non uniformity of the x-ray beam.
5. A method in accordance with claim 1 wherein the detector is a multislice detector.
6. A method for monitoring cell to cell variation in a detector of a computed tomography system, the system including an x-ray source for producing an x-ray beam along an imaging plane, the detector including a plurality of detector cells extending in a z-axis and arranged in a plurality of detector cell modules, said method comprising:
performing an air scan;
obtaining data from the detector cells;
performing a trending analysis to predict when a detector will fail the specification;
comparing the cell data to a specification to determine cells not within parameters of the specification; and
replacing a detector cell module in which a detector cell is not within the specification parameters.
7. An imaging system comprising an x-ray source and at least one multislice detector module, each detector module including a plurality of detector cells extending in a z-axis and arranged in a plurality of detector cell modules, said system configured to:
perform an air scan;
obtain data from the detector cells from the air scan; and
compare the cell data to a specification,
and further wherein said plurality of detector cell modules are configured to be replaceable when a cell within a module is determined to be outside of parameters of the specification.
8. A system in accordance with claim 7 wherein the scan is an air scan.
9. A system in accordance with claim 7 wherein said system is further configured to normalize the cell data.
10. A system in accordance with claim 9 wherein said system is further configured to compensate for non uniformity of the x-ray beam.
11. A system in accordance with claim 7 wherein said detector is a multislice detector.
12. An imaging system comprising an x-ray source and at least one multislice detector module, each detector module including a plurality of detector cells extending in a z-axis and arranged in a plurality of detector cell modules, said system configured to:
perform a scan;
obtain data from the detector cells;
compare the cell data to a specification; and
perform a trending analysis to predict when a detector will fail the specification;
said plurality of detector cell modules configured to be replaceable when a cell within a module is determined to be outside of parameters of the specification.
13. A system in accordance with claim 12 further comprising a remote support center for initiating performance of the air scan.
14. A multislice computed tomography system comprising an x-ray source for producing an x-ray beam along an imaging plane and a detector comprising a plurality of detector cells extending in a z-axis and arranged in a plurality of detector cell modules, said system configured to monitor cell to cell gain variations by:
performing an air scan;
obtaining data from the detector cells for the air scan;
comparing the cell data to a specification,
and further wherein said plurality of detector cell modules are configured to be replaceable when a cell within a module is determined to be outside of parameters of the specification.
15. A system in accordance with claim 14 wherein the scan is an air scan.
16. A system in accordance with claim 14 wherein said system is further configured to normalize the cell data.
17. A system in accordance with claim 16 further configured to compensate for non uniformity of the x-ray beam.
18. A multislice computed tomography system comprising an x-ray source for producing an x-ray beam along an imaging plane and a detector comprising a plurality of detector cells extending in a z-axis and arranged in a plurality of detector cell modules, said system configured to monitor cell to cell gain variations by:
performing an air scan;
obtaining data from the detector cells for the air scan;
comparing the cell data to a specification; and
performing a trending analysis to predict when a detector will fail the specification;
said plurality of detector cell modules configured to be replaceable when a cell within a module is determined to be outside of parameters of the specification.
19. A system in accordance with claim 18 further comprising a remote support center for initiating performance of the air scan.
20. A method for monitoring cell to cell variation in a detector of a computed tomography system, the system including an x-ray source for producing an x-ray beam along an imaging plane, the detector including a plurality of detector cells extending in a z-axis, said method comprising:
performing a scan;
obtaining data from the detector cells;
performing a trending analysis of the data obtained from the detector cells to predict when a detector will fail the specification.
21. A method in accordance with claim 20 further wherein the data is obtained and analyzed by an automated support center remote from the computed tomography system.
22. A method in accordance with claim 21 wherein performing a trending analysis comprises performing a least squares fit to a linear model of each element of a gain matrix as a function of time.
23. A method in accordance with claim 22 and further comprising utilizing results of the trending analysis to replace the detector prior to its failure.
24. An imaging system comprising an x-ray source and at least one multislice detector module, each detector module including a plurality of detector cells extending in a z-axis, said system configured to:
perform a scan;
obtain data from the detector cells; and
to perform a trending analysis to predict when a detector will fail the specification.
25. An imaging system in accordance with claim 24 wherein to perform said trending analysis, said imaging system is configured to perform a least squares fit to a linear model of each element of a gain matrix as a function of time.
26. A multislice computed tomography system comprising an x-ray source for producing an x-ray beam along an imaging plane and a detector comprising a plurality of detector cells extending in a z-axis, said system configured to monitor cell to cell gain variations by:
performing a scan;
obtaining data from the detector cells; and
perform a trending analysis to predict when a detector will fail the specification.
27. A system in accordance with claim 26 wherein to perform said trending analysis, said system is configured to perform a least squares fit to a linear model of each element of a gain matrix as a function of time.
US09/140,110 1998-08-25 1998-08-25 Methods and apparatus for monitoring detector image quality Expired - Lifetime US6327329B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US09/140,110 US6327329B1 (en) 1998-08-25 1998-08-25 Methods and apparatus for monitoring detector image quality
IL13140299A IL131402A (en) 1998-08-25 1999-08-15 Methods and apparatus for monitoring detector image quality
JP23222899A JP4782905B2 (en) 1998-08-25 1999-08-19 Method and computerized tomography system for monitoring variation between detector cells
EP99306635A EP0982683A3 (en) 1998-08-25 1999-08-20 Methods and apparatus for monitoring detector image quality

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/140,110 US6327329B1 (en) 1998-08-25 1998-08-25 Methods and apparatus for monitoring detector image quality

Publications (1)

Publication Number Publication Date
US6327329B1 true US6327329B1 (en) 2001-12-04

Family

ID=22489804

Family Applications (1)

Application Number Title Priority Date Filing Date
US09/140,110 Expired - Lifetime US6327329B1 (en) 1998-08-25 1998-08-25 Methods and apparatus for monitoring detector image quality

Country Status (4)

Country Link
US (1) US6327329B1 (en)
EP (1) EP0982683A3 (en)
JP (1) JP4782905B2 (en)
IL (1) IL131402A (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6535572B2 (en) * 2001-06-15 2003-03-18 Ge Medical Systems Global Technology Company, Llc Methods and apparatus for compensating computed tomographic channel ganging artifacts
US6652143B2 (en) * 2001-04-12 2003-11-25 Siemens Aktiengesellschaft Method and apparatus for measuring the position, shape, size and intensity distribution of the effective focal spot of an x-ray tube
DE10237546A1 (en) * 2002-08-16 2004-03-11 Siemens Ag X ray computer tomography unit has copper or aluminum wedge or step filter between anode and detector array
US20040174951A1 (en) * 2003-03-03 2004-09-09 Hoffman David M. Ct detector with integrated air gap
US6888946B2 (en) * 2000-05-23 2005-05-03 Harman Audio Electronic Systems Gmbh High frequency loudspeaker
US20050259784A1 (en) * 2004-05-20 2005-11-24 Xiaoye Wu Methods for spectrally calibrating CT imaging apparatus detectors
US7062011B1 (en) * 2002-12-10 2006-06-13 Analogic Corporation Cargo container tomography scanning system
US20060159222A1 (en) * 2003-02-20 2006-07-20 Amiaz Altman Asymmetric cone beam
US20060159223A1 (en) * 2005-01-14 2006-07-20 General Electric Company Method and apparatus for correcting for beam hardening in CT images
US20070235654A1 (en) * 2004-11-22 2007-10-11 Ge Medical Systems Global Technology Company, Llc X-ray radiation detector, x-ray imaging apparatus, x-ray ct apparatus and method of manufacturing x-ray detector
US20080123816A1 (en) * 2004-03-29 2008-05-29 National Institute Of Radiological Sciences Heel Effect Compensation Filter X-Ray Irradiator, X-Ray Ct Scanner and Method for X-Ray Ct Imaging

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100446638B1 (en) * 2001-10-04 2004-09-04 주식회사 팬택앤큐리텔 Packet terminal capable of supporting multiple packet calls and method for supporting multiple packet calls in the same
JP2005028114A (en) * 2003-06-18 2005-02-03 Canon Inc Radiation photographing apparatus and radiation photographing method
US7020243B2 (en) * 2003-12-05 2006-03-28 Ge Medical Systems Global Technology Company Llc Method and system for target angle heel effect compensation
JP2009538670A (en) * 2006-06-02 2009-11-12 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ X-ray imaging apparatus, and apparatus and method for calibrating X-ray imaging apparatus
JP5216680B2 (en) * 2009-04-23 2013-06-19 株式会社日立メディコ X-ray CT apparatus and data acquisition method using the same
JP5995491B2 (en) * 2012-04-06 2016-09-21 株式会社日立製作所 X-ray CT system

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430785A (en) * 1994-04-11 1995-07-04 General Electric Company Detector channel gain calibration using focal spot wobble
US5473663A (en) * 1994-09-12 1995-12-05 General Electric Company Method for evaluating the performance of detectors in a computed tomography system
US5521482A (en) * 1993-06-29 1996-05-28 Liberty Technologies, Inc. Method and apparatus for determining mechanical performance of polyphase electrical motor systems
US5734691A (en) * 1996-12-23 1998-03-31 General Electric Company Detector z-axis gain non-uniformity correction in a computed tomography system
US5845003A (en) 1995-01-23 1998-12-01 General Electric Company Detector z-axis gain correction for a CT system
US6115448A (en) 1997-11-26 2000-09-05 General Electric Company Photodiode array for a scalable multislice scanning computed tomography system
US6134292A (en) 1998-07-13 2000-10-17 General Electric Company Methods and apparatus for reducing z-axis non-uniformity artifacts

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0109205A3 (en) * 1982-11-15 1985-07-31 Picker International, Inc. Method and apparatus for computed tomography imaging
JPS6456036A (en) * 1987-08-26 1989-03-02 Hitachi Medical Corp X-ray ct apparatus
JP2882048B2 (en) * 1990-11-29 1999-04-12 松下電器産業株式会社 Sensing element sensitivity correction method and X-ray detector
US5301108A (en) * 1993-02-01 1994-04-05 General Electric Company Computed tomography system with z-axis correction
US5931780A (en) * 1993-11-29 1999-08-03 Arch Development Corporation Method and system for the computerized radiographic analysis of bone
US5450461A (en) * 1993-12-30 1995-09-12 General Electric Company Self-calibrating computed tomography imaging system
US5533081A (en) * 1995-01-17 1996-07-02 General Electric Company Guided ringfix algorithm for image reconstruction
JP3549169B2 (en) * 1995-03-10 2004-08-04 株式会社日立メディコ X-ray CT system
JPH09248301A (en) * 1996-03-15 1997-09-22 Ge Yokogawa Medical Syst Ltd Characteristic improving method for x-ray detector and x-ray ct system
JP3763611B2 (en) * 1996-07-12 2006-04-05 株式会社東芝 X-ray CT scanner

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521482A (en) * 1993-06-29 1996-05-28 Liberty Technologies, Inc. Method and apparatus for determining mechanical performance of polyphase electrical motor systems
US5430785A (en) * 1994-04-11 1995-07-04 General Electric Company Detector channel gain calibration using focal spot wobble
US5473663A (en) * 1994-09-12 1995-12-05 General Electric Company Method for evaluating the performance of detectors in a computed tomography system
US5845003A (en) 1995-01-23 1998-12-01 General Electric Company Detector z-axis gain correction for a CT system
US5734691A (en) * 1996-12-23 1998-03-31 General Electric Company Detector z-axis gain non-uniformity correction in a computed tomography system
US6115448A (en) 1997-11-26 2000-09-05 General Electric Company Photodiode array for a scalable multislice scanning computed tomography system
US6134292A (en) 1998-07-13 2000-10-17 General Electric Company Methods and apparatus for reducing z-axis non-uniformity artifacts

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6888946B2 (en) * 2000-05-23 2005-05-03 Harman Audio Electronic Systems Gmbh High frequency loudspeaker
US6652143B2 (en) * 2001-04-12 2003-11-25 Siemens Aktiengesellschaft Method and apparatus for measuring the position, shape, size and intensity distribution of the effective focal spot of an x-ray tube
US6535572B2 (en) * 2001-06-15 2003-03-18 Ge Medical Systems Global Technology Company, Llc Methods and apparatus for compensating computed tomographic channel ganging artifacts
DE10237546A1 (en) * 2002-08-16 2004-03-11 Siemens Ag X ray computer tomography unit has copper or aluminum wedge or step filter between anode and detector array
DE10237546B4 (en) * 2002-08-16 2007-11-29 Siemens Ag X-ray computed tomography device with filter
US7062011B1 (en) * 2002-12-10 2006-06-13 Analogic Corporation Cargo container tomography scanning system
US20060159222A1 (en) * 2003-02-20 2006-07-20 Amiaz Altman Asymmetric cone beam
US7340030B2 (en) 2003-02-20 2008-03-04 Koninklijke Philips Electronics N.V. Asymmetric cone beam
US6907101B2 (en) * 2003-03-03 2005-06-14 General Electric Company CT detector with integrated air gap
CN1303434C (en) * 2003-03-03 2007-03-07 Ge医药系统环球科技公司 CT detector with integral air gap
US20040174951A1 (en) * 2003-03-03 2004-09-09 Hoffman David M. Ct detector with integrated air gap
US20080123816A1 (en) * 2004-03-29 2008-05-29 National Institute Of Radiological Sciences Heel Effect Compensation Filter X-Ray Irradiator, X-Ray Ct Scanner and Method for X-Ray Ct Imaging
US7430282B2 (en) 2004-03-29 2008-09-30 National Institute Of Radiological Sciences Heel effect compensation filter X-ray irradiator, X-ray CT scanner and method for X-ray CT imaging
US20050259784A1 (en) * 2004-05-20 2005-11-24 Xiaoye Wu Methods for spectrally calibrating CT imaging apparatus detectors
US7086780B2 (en) 2004-05-20 2006-08-08 General Electric Company Methods for spectrally calibrating CT imaging apparatus detectors
US20070235654A1 (en) * 2004-11-22 2007-10-11 Ge Medical Systems Global Technology Company, Llc X-ray radiation detector, x-ray imaging apparatus, x-ray ct apparatus and method of manufacturing x-ray detector
US7291844B2 (en) 2004-11-22 2007-11-06 Ge Medical Systems Global Technology Company, Llc X-ray radiation detector, X-ray imaging apparatus, X-ray CT apparatus and method of manufacturing X-ray detector
US20060159223A1 (en) * 2005-01-14 2006-07-20 General Electric Company Method and apparatus for correcting for beam hardening in CT images
US7391844B2 (en) 2005-01-14 2008-06-24 General Electric Company Method and apparatus for correcting for beam hardening in CT images

Also Published As

Publication number Publication date
IL131402A (en) 2003-07-06
EP0982683A2 (en) 2000-03-01
IL131402A0 (en) 2001-01-28
EP0982683A3 (en) 2003-11-26
JP2000079114A (en) 2000-03-21
JP4782905B2 (en) 2011-09-28

Similar Documents

Publication Publication Date Title
US6327329B1 (en) Methods and apparatus for monitoring detector image quality
US6370218B1 (en) Methods and systems for determining x-ray beam position in multi-slice computed tomography scanners
US6056437A (en) Methods and apparatus for imaging system detector alignment
US5583903A (en) Computed tomography apparatus
US6256364B1 (en) Methods and apparatus for correcting for x-ray beam movement
US6295331B1 (en) Methods and apparatus for noise compensation in imaging systems
US5982846A (en) Methods and apparatus for dose reduction in a computed tomograph
US6421411B1 (en) Methods and apparatus for helical image artifact reduction
US6173039B1 (en) Variable aperture z-axis tracking collimator for computed tomograph system
US6061419A (en) Methods and apparatus for noise compensation in an imaging system
US6134292A (en) Methods and apparatus for reducing z-axis non-uniformity artifacts
JP2002200068A (en) System and method for radiation tomographic imaging
US6280084B1 (en) Methods and apparatus for indirect high voltage verification in an imaging system
KR20050028824A (en) Radiation computed tomography apparatus and tomographic image data generating method
US6325539B1 (en) Calibration simplification for a computed tomograph system
US6141402A (en) Methods and apparatus for dose verification in an imaging system
US6870898B1 (en) Computed tomography apparatus with automatic parameter modification to prevent impermissible operating states
US6343110B1 (en) Methods and apparatus for submillimeter CT slices with increased coverage
US6118840A (en) Methods and apparatus to desensitize incident angle errors on a multi-slice computed tomograph detector
US6937697B2 (en) X-ray data collecting apparatus and X-ray CT apparatus
US6304625B1 (en) Dose instrumentation methods and apparatus for collimated CT imaging systems
US6307912B1 (en) Methods and apparatus for optimizing CT image quality with optimized data acquisition
US7101078B1 (en) Methods and systems for imaging system radiation source alignment
US6075835A (en) Methods and apparatus for imaging system quality readiness check

Legal Events

Date Code Title Description
AS Assignment

Owner name: GENERAL ELECTRIC COMPANY, NEW YORK

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BROMBERG, NEIL B.;HE, HUI DAVID;KULPINS, MARY SUE;REEL/FRAME:009594/0772

Effective date: 19981001

STCF Information on status: patent grant

Free format text: PATENTED CASE

CC Certificate of correction
FPAY Fee payment

Year of fee payment: 4

FPAY Fee payment

Year of fee payment: 8

FPAY Fee payment

Year of fee payment: 12