US6287549B1 - Method for removing superfluous hairs - Google Patents
Method for removing superfluous hairs Download PDFInfo
- Publication number
- US6287549B1 US6287549B1 US09/402,351 US40235199A US6287549B1 US 6287549 B1 US6287549 B1 US 6287549B1 US 40235199 A US40235199 A US 40235199A US 6287549 B1 US6287549 B1 US 6287549B1
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- US
- United States
- Prior art keywords
- microparticles
- chromophores
- skin
- composition
- laser
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
- A61Q7/02—Preparations for inhibiting or slowing hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/18—Working by laser beam, e.g. welding, cutting or boring using absorbing layers on the workpiece, e.g. for marking or protecting purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
- A61B2017/22085—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance light-absorbing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/00476—Hair follicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
Definitions
- the invention relates to a method for preventing the regrowth of hairs and/or for eliminating hairs using a composition which is intended to be applied to the skin before a laser treatment and comprises microparticles of specific size comprising at least one chromophore.
- U.S. Pat. Nos. 3,538,919 and 4,617,926 describe depilation methods using the light energy which is emitted by a laser and is transmitted by an optical fibre, which targets and eliminates the hairs one by one.
- U.S. Pat. No. 5,059,919 describes a depilation method using a laser placed at the orifice of the pilosebaceous unit whose light energy is absorbed by the melanin situated in the dermic papilla.
- U.S. Pat. No. 5,425,728 proposed irradiating a large area of the skin with a laser after application to this part of the skin of a composition comprising a chromophore exhibiting significant absorbence at the wavelength of the light emitted by the laser.
- This chromophore is more particularly carbon particles of average size between 10 and 20 nm.
- this method has certain drawbacks: the small size of these particles does not allow the pilosebaceous units to be penetrated deeply and selectively. This is because these particles may end up in the pores of the skins or alternatively in wrinkles, which causes an undesired lesion of parts of the skin during the irradiation.
- the object of the present invention is therefore to provide a depilation method which overcomes the drawbacks described above.
- Its object is to provide a depilation method which makes it possible to target the pilosebaceous unit with particles:
- the light energy of the laser radiation into heat energy, in the case of using a laser radiation of emission time longer than 50 ⁇ s, which reduces the risks of irreversible lesions of the perifollicular tissues, that is to say those surrounding the follicle, while making it possible to damage and/or kill the cells responsible for the growth of the hair.
- the present invention relates to a method for preventing the regrowth of hairs and/or of eliminating hairs, characterized in that it comprises the following steps:
- composition comprising, in a physiologically acceptable medium, microparticles of which at least 80% by weight have a diameter of between 3 ⁇ m and 10 ⁇ m, comprising chromophores, is applied to a surface of the skin, where the hairs are situated,
- a composition comprising a solvent which dissolves the chromophores used in step (1) is applied to the said surface of the skin,
- At least one laser radiation is applied to the said surface of the skin in one or more shots, the emitted wavelength of which is absorbed by the chromophores of the composition applied in step (1) and the light energy and the emission duration of which are sufficient to damage and/or kill the cells responsible for the growth of the hair.
- the diameter of the microparticles can be measured by scattering of light (Coulter counter) or by microscopy followed by image analysis.
- microparticles of determined diameters thus penetrate into the hair follicle but little through the corneal layer. This phenomenon is described in Patent EP 0375520.
- the microparticles selectively and progressively reach the follicular channel where the chromophores contained in these microparticles are ready to absorb the light emitted by the laser.
- microparticles may be of any kind and obtained by any known method.
- the synthetic polymers that can be used may advantageously be selected from: polymers based on styrene, polyamides, polymers based on ⁇ -alanine, polymers derived from acrylic or methacrylic acid, polyesters derived from lactic and/or glycolic acid.
- the natural polymers may be selected from proteins (gelatin, albumin, casein, etc.) and polysaccharides (alginates, chitosan, etc.).
- the microparticles used for the present invention may be formed by fatty substances.
- the fatty substances that can be used may advantageously be selected from derivatives of alcohols and of fatty acids, such as tristearin, semi-synthetic triglycerides or glycerol monostearate, and fatty alcohols such as cetyl alcohol. They preferably have a melting point above or equal to 50° C.
- Vesicular microparticles may also be used as liposomes and, preferably, polymerized liposomes whether reverse or forward.
- microparticles emulsifying, atomizing, microionizing in the case of chromophore particles etc.
- the methods for obtaining these microparticles may be adapted in order to obtain the desired particle size distribution by appropriately controlling their manufacturing process or by carrying out screening when the size distribution is broad. It is, for example, possible to adjust the size of the microparticles by selecting the polymerization solvent, the crosslinking agent or by modifying the stirring speed or time of the reaction medium.
- the chromophores contained in the microparticles may be on the inside and/or on the surface of the microparticles, so long as their presence does not generate microparticles with a particle size distribution departing from the scope of the invention. These chromophores may form an integral part of the microparticle or alternatively be the microparticle itself. When the chromophores are the microparticle, these chromophores are preferably of density strictly less than 2.25 g/cm 3 (density of graphite particles).
- the chromophores are preferably on the inside of the microparticles.
- the chromophore or chromophores may be combined with the microparticles by any known means.
- This combination may be carried out simultaneously with the formation of the microparticle, or after its formation.
- the chromophores and the polymer are dissolved in an organic solvent that is immiscible with water.
- the solution is then emulsified in an aqueous phase with a surfactant.
- the procedure adopted may be to impregnate the microparticles with the aid of a solution containing the chromophores, such as may be the case with impregnating the Orgasol (Atochem) polyamide microparticles.
- the chromophores may be any chemical entity which absorbs sufficiently at the wavelength in question, that is to say any chemical entity which, when it is contained in the composition applied according to the invention, makes it possible to convert the light energy which it absorbs into sufficient energy to damage and/or kill the cells responsible for the growth of the hair. More particularly, they may be of mineral origin, such as carbon black, graphite, red and black iron oxide, or of organic origin, such as melanin, indocyanine green, phthalocyanines and their metal complexes.
- the microparticles comprising the chromophores may be dispersed in any medium which is physiologically acceptable and does not lead to the release of the said chromophores.
- the dispersing phase may be a hydrophilic or hydrophobic composition or an emulsion.
- the dispersing phase may thus, in particular, be in the form of a gel, milk, lotion, ointment, cream or salve.
- a hydrophilic composition may be an aqueous gel or an aqueous-alcoholic gel. This may be obtained with the aid of a gelling agent, such as the crosslinked polyacrylic acid marketed under the brand name Carbopol® by the company Goodrich® or the cellulose derivatives marketed under the brand name Klucel® by the company Hercules®.
- a gelling agent such as the crosslinked polyacrylic acid marketed under the brand name Carbopol® by the company Goodrich® or the cellulose derivatives marketed under the brand name Klucel® by the company Hercules®.
- a hydrophobic composition may consist of oils such as acid esters, like fatty acid triglycerides, fatty alcohol esters, or their mixtures, alkanes, like liquid petroleum jelly, or else silicones.
- the composition according to the present invention comprises less than 40% by weight, and preferably contains from 10 ⁇ 4 % to 40% by weight, of microparticles, at least 80% of which have a diameter of between 3 and 10 ⁇ m.
- At least 80% of the microparticles comprising at least one chromophore have a diameter of between 4 and 7 ⁇ m.
- step (1) The application of the composition described in step (1) may be carried out by simple deposition or by a massage. Before step (1), depilation or shaving of the surface of the skin to be treated may be envisaged, in particular in order to make the hair follicles more accessible.
- Step (2) of removing the composition applied in (1) which is still on the surface of the skin generally consists in a simple cleaning of the surface of the skin, and this cleaning is more particularly carried out with the vehicle (the medium) used for the composition used in (1).
- the cleaning (2) makes it possible to take away the majority of the composition applied in (1) which has not penetrated into the pilosebaceous units (in particular inside creases and wrinkles).
- the optional step (3) makes it possible to free the chromophores from the microparticles by dissolving and to make them penetrate more deeply into the hair follicle and/or be further dispersed in the hair follicle. This is particularly beneficial in the case of chromophores which are not in a particulate form, like in particular organic chromophores.
- the solvents may, for example, be water, C 1 to C 4 alcohols, such as ethanol, propanol, isopropanol, 1-butanol, and esters such as ethyl acetate or butyl acetate.
- any type of laser may be used, although a laser emitting light at a wavelength of between 350 nm and 2.5 ⁇ m is preferably used.
- lasers examples include Nd:YAG lasers (1064 nm or 532 nm), Ho:YAG lasers (2.12 ⁇ m), ruby lasers (694 nm) and dye lasers (585 nm) and diode lasers such as, for example, a diode laser (800 nm).
- the light energy and the emission time which are sufficient to damage and/or kill the cells responsible for the growth of the hair can vary in a large extent as a function of the type of laser, chromophores selected and the composition comprising them.
- the light energy applied is such that the chromophores are ionized, which generates shock waves that propagate in the tissues as far as the dermic papilla in order to damage and/or kill the cells responsible for the growth of the hair.
- one of the advantages of the invention is that it is not necessary to fraction the chromophores, as was the case in the prior art.
- the number of shots needed to ionize the chromophores is thus smaller, and this makes it possible to reduce the risks of irreversible lesions of the perifollicular tissues, that is to say the tissues which surround the hair follicle.
- This number of shots is preferably less than 5. This is the case, for example, for nanometric carbon particles.
- the light energy applied is such that the chromophores convert the light energy emitted by the laser into heat energy, this heat energy then being transmitted by conduction as far as the dermic papilla in order to damage and/or kill the cells responsible for the growth of the hair.
- a laser having an emission time less than or equal to 50 ⁇ s is used.
- the wavelength, the emission time and the light energy of the radiation of the laser are chosen as a function of the absorbence of the composition used comprising the chromophores. More particularly, as a function of the composition used comprising the chromophores, these parameters correspond to those allowing weak, or even zero absorption, of the light by the various constituents of the first layers of the skin, and significant absorption by the chromophore used, the aim of this being to avoid any irreversible lesion of the skin.
- This significant absorption corresponds to that which is sufficient to damage and/or kill the cells responsible for the growth of the hair.
- the undesired irreversible lesions of the skin correspond, in particular, to impairment of the capillary vessels lying in the dermis by coagulation of haemoglobin or irreversible destruction of melanocytes, Langerhans cells, keratinocytes or fibroblasts, in particular by volatilization of the endogenous chromophores contained in these cells or their precursors, such as water, melanin or proteins.
- FIGS. 1 to 5 on sheets 1 / 3 to 3 / 3 allow the invention to be better illustrated, but without limiting its scope. These figures correspond to a diagrammatic representation of a pilosebaceous unit.
- FIG. 1 summarizes the structure of the pilosebaceous unit, the hairs being produced by the hair follicles A, cylindrical invaginations of the basal layer of the epithelium with surface surrounded by connective tissue.
- the hair grows inside the hair bulb B situated at the base of the follicles.
- the hair follicle is a tubular structure consisting of five concentric layers of epithelial cells.
- the epithelial cells surrounding the dermic papilla proliferate to form the inner four layers of the follicle.
- the bulb consists of epithelial cells with high mitotic power. At the bulb, all the layers fuse. During the growth of the hair, the epithelial cells surrounding the dermic papilla proliferate to form the inner four layers of the follicle.
- the inner three layers undergo keratinization to form the hair proper.
- the outer two layers form the outer epithelial sheath 1 .
- the cells of the innermost layer of the follicle undergo moderate keratinization leading to the formation of the medulla 2 at the heart of the hair.
- the medulla is surrounded by a thick layer, highly keratinzed, the cortex 3 which forms the most important part of the hair.
- the third layer forms the cuticle 4 , a thin hard layer coating surface of the hair.
- the cells of the fourth layer of the follicle are only minorly keratinized. It disappears at the channels of the sebaceous glands 5 leaving a space, the ostium 6 .
- composition described in this example is applied to the surface of the skin in excess (FIG. 2 ). After gentle massage for a few minutes, some of the microparticles 8 of calibrated size contained in the formulation will descend along the hair shaft into the ostium 9 to the level of the sebaceous glands.
- FIG. 3 After having cleaned the surface of the skin with the vehicle of the formulation, FIG. 3, the microparticles loaded with exogenous chromophores 10 only remain in the ostium.
- the laser used in this example is an Nd:YAG laser emitting a radiation of wavelength 1064 nm and having an emission time of 7-12 ns. At this wavelength, the radiation is absorbed very little by the various constituents of the first layers of the skin and is principally absorbed by the exogenous chromophore contained in the microparticles.
- FIG. 4 shows the irradiation of the pilosebaceous unit where a small fraction of the energy delivered 11 is reflected 12 (5%) by the surface of the skin and another fraction transmitted. The photons transmitted into the skin are either scattered 13 (10%) or absorbed by the exogenous chromophore 14 .
- FIGS. 5A, 5 B, 5 C describe the interaction between the photons transmitted into the skin and a microparticle.
- FIG. 5A shows a microparticle 15 placed in the ostium 16 situated around the hair shaft 17 .
- the microparticles used when they are not loaded with exogenous chromophores, absorb the employed wavelength little.
- the incorporation of carbon black particles 18 of particle size distribution centred around 13 nm in the microparticles of particle size distribution centred on 5 ⁇ m ( ⁇ 1.5 ⁇ m) makes it possible for fine particles absorbing strongly the wavelength used to be placed selectively in the pilosebaceous unit.
- FIG. 5B describes the absorption of the photons transmitted into the skin by the carbon particles. Because of their small particle size distribution, the carbon particles sublime and form a plasma 19 in one to two laser shots. At the boundary between the plasma and the external medium (the ostium), FIG. 5C, a pressure gradient appears which induces the formation of a shockwave 20 that propagates in the adjacent tissues as far as the hair bulb in order to damage/eliminate the cells responsible for the growth of the hair.
- Composition example % by mass Part A FW1 gas black (Degussa) 0.2 Parleam oil 1.55 Solsperse 21000 (ICI) 0.05 Orgasol 2002 UD Nat Cos (Elf Atochem) 7.3
- Part B aqueous gel Carbopol 980 (BF Goodrich) 0.9 5% strength sodium hydroxide 7.3 Water 82.7
- the pigment is dispersed in the oily mixture, then the Orgasol microparticles are impregnated with the lipophilic dispersion, this constituting part A.
- the Orgasol microparticles thus loaded are then dispersed in the aqueous gel (corresponding to part B).
Abstract
Description
Composition example | % by mass | ||
Part A: | |||
FW1 gas black (Degussa) | 0.2 | ||
Parleam oil | 1.55 | ||
Solsperse 21000 (ICI) | 0.05 | ||
Orgasol 2002 UD Nat Cos (Elf Atochem) | 7.3 | ||
Part B: aqueous gel | |||
Carbopol 980 (BF Goodrich) | 0.9 | ||
5% strength sodium hydroxide | 7.3 | ||
Water | 82.7 | ||
Claims (21)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9705297 | 1997-04-29 | ||
FR9705297A FR2762504B1 (en) | 1997-04-29 | 1997-04-29 | HAIR REMOVAL PROCESS |
PCT/FR1998/000850 WO1998048716A1 (en) | 1997-04-29 | 1998-04-28 | Method for removing superfluous hairs |
Publications (1)
Publication Number | Publication Date |
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US6287549B1 true US6287549B1 (en) | 2001-09-11 |
Family
ID=9506428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/402,351 Expired - Lifetime US6287549B1 (en) | 1997-04-29 | 1998-04-28 | Method for removing superfluous hairs |
Country Status (15)
Country | Link |
---|---|
US (1) | US6287549B1 (en) |
EP (1) | EP1014876A1 (en) |
JP (1) | JP2001500529A (en) |
CN (1) | CN1253486A (en) |
AU (1) | AU728499B2 (en) |
BR (1) | BR9808107A (en) |
CA (1) | CA2285678A1 (en) |
FR (1) | FR2762504B1 (en) |
HU (1) | HUP0002344A2 (en) |
IL (1) | IL131961A0 (en) |
NO (1) | NO995246L (en) |
NZ (1) | NZ337292A (en) |
PL (1) | PL336631A1 (en) |
RU (1) | RU2192295C2 (en) |
WO (1) | WO1998048716A1 (en) |
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US6685927B2 (en) | 2001-09-27 | 2004-02-03 | Ceramoptec Industries, Inc. | Topical application of chromophores for hair removal |
FR2856594A1 (en) * | 2003-06-26 | 2004-12-31 | Oreal | POROUS PARTICLES LOADED WITH COSMETIC (S) OR PHARMACEUTICAL (S) ACTIVE COMPOUND (S) |
US20050031699A1 (en) * | 2003-06-26 | 2005-02-10 | L'oreal | Porous particles loaded with cosmetically or pharmaceutically active compounds |
US20070060819A1 (en) * | 2005-09-15 | 2007-03-15 | Palomar Medical Technologies, Inc. | Skin optical characterization device |
US20070154536A1 (en) * | 2000-07-21 | 2007-07-05 | Ceramoptec Industries Inc. | Drug delivery method by enhanced topical application |
WO2008080038A2 (en) * | 2006-12-22 | 2008-07-03 | Mcneil-Ppc, Inc. | Epilation compositions having high temperature-sensitivity |
US7837675B2 (en) | 2004-07-22 | 2010-11-23 | Shaser, Inc. | Method and device for skin treatment with replaceable photosensitive window |
US7955234B1 (en) | 2007-02-28 | 2011-06-07 | Pursley Michael G | Exercise device and method |
US20110172651A1 (en) * | 1997-05-15 | 2011-07-14 | Palomar Medical Technolgies, Inc. | Heads For Dermatology Treatment |
US8182473B2 (en) | 1999-01-08 | 2012-05-22 | Palomar Medical Technologies | Cooling system for a photocosmetic device |
US8328796B2 (en) | 1997-05-15 | 2012-12-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
WO2013079105A1 (en) | 2011-11-30 | 2013-06-06 | Fundació Institut De Ciències Fotòniques | Method for enhanced photoepilation based on metallic nano-complexes |
US8915948B2 (en) | 2002-06-19 | 2014-12-23 | Palomar Medical Technologies, Llc | Method and apparatus for photothermal treatment of tissue at depth |
US9028536B2 (en) | 2006-08-02 | 2015-05-12 | Cynosure, Inc. | Picosecond laser apparatus and methods for its operation and use |
US9061056B2 (en) | 2010-08-27 | 2015-06-23 | Sienna Labs, Inc. | Compositions and methods for targeted thermomodulation |
US9212294B2 (en) | 2012-10-11 | 2015-12-15 | Nanocomposix, Inc. | Silver nanoplate compositions and methods |
US9572880B2 (en) | 2010-08-27 | 2017-02-21 | Sienna Biopharmaceuticals, Inc. | Ultrasound delivery of nanoparticles |
US9780518B2 (en) | 2012-04-18 | 2017-10-03 | Cynosure, Inc. | Picosecond laser apparatus and methods for treating target tissues with same |
US9919168B2 (en) | 2009-07-23 | 2018-03-20 | Palomar Medical Technologies, Inc. | Method for improvement of cellulite appearance |
US10245107B2 (en) | 2013-03-15 | 2019-04-02 | Cynosure, Inc. | Picosecond optical radiation systems and methods of use |
US10434324B2 (en) | 2005-04-22 | 2019-10-08 | Cynosure, Llc | Methods and systems for laser treatment using non-uniform output beam |
US20190388134A1 (en) * | 2018-06-22 | 2019-12-26 | Avava, Inc. | Apparatus for selective treatment of tissue |
US11039887B2 (en) | 2013-08-09 | 2021-06-22 | The General Hospital Corporation | Method and apparatus for treating dermal melasma |
US11418000B2 (en) | 2018-02-26 | 2022-08-16 | Cynosure, Llc | Q-switched cavity dumped sub-nanosecond laser |
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MY131835A (en) | 1998-11-20 | 2007-09-28 | Gen Hospital Corp | Permanent, removable tissue markings |
AUPQ044499A0 (en) * | 1999-05-19 | 1999-06-10 | Commonwealth Scientific And Industrial Research Organisation | Control of wool growth |
GB0002719D0 (en) * | 2000-02-08 | 2000-03-29 | Tissuemed Ltd | Thermal ablation of tissue |
WO2002060531A1 (en) | 2001-01-29 | 2002-08-08 | Ya-Man Ltd. | Laser depilating method and laser depilating apparatus |
MX2007007623A (en) * | 2004-12-22 | 2007-08-03 | Gillette Co | Reduction of hair growth. |
KR100918215B1 (en) * | 2004-12-22 | 2009-09-21 | 더 질레트 컴퍼니 | Reduction of hair growth |
JP6185990B2 (en) * | 2012-07-10 | 2017-08-23 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | Release of molecules from containers by selective heating of hair |
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EP0375520A1 (en) | 1988-12-20 | 1990-06-27 | Centre International De Recherches Dermatologiques Galderma - Cird Galderma | Cosmetic or pharmaceutical composition containing microspheres of polymers or lipids charged with at least one active substance |
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CA2131750A1 (en) | 1994-07-26 | 1996-01-27 | Nikolai I. Tankovich | Improved hair removal method |
US5817089A (en) * | 1991-10-29 | 1998-10-06 | Thermolase Corporation | Skin treatment process using laser |
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- 1998-04-28 CN CN98804566A patent/CN1253486A/en active Pending
- 1998-04-28 RU RU99125123/14A patent/RU2192295C2/en not_active IP Right Cessation
- 1998-04-28 EP EP98922884A patent/EP1014876A1/en not_active Withdrawn
- 1998-04-28 BR BR9808107-1A patent/BR9808107A/en not_active IP Right Cessation
- 1998-04-28 IL IL13196198A patent/IL131961A0/en unknown
- 1998-04-28 WO PCT/FR1998/000850 patent/WO1998048716A1/en not_active Application Discontinuation
- 1998-04-28 HU HU0002344A patent/HUP0002344A2/en unknown
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- 1998-04-28 JP JP10546673A patent/JP2001500529A/en active Pending
- 1998-04-28 AU AU75366/98A patent/AU728499B2/en not_active Ceased
- 1998-04-28 PL PL98336631A patent/PL336631A1/en unknown
- 1998-04-28 US US09/402,351 patent/US6287549B1/en not_active Expired - Lifetime
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Also Published As
Publication number | Publication date |
---|---|
AU7536698A (en) | 1998-11-24 |
NZ337292A (en) | 2001-04-27 |
CA2285678A1 (en) | 1998-11-05 |
EP1014876A1 (en) | 2000-07-05 |
FR2762504B1 (en) | 1999-09-10 |
WO1998048716A1 (en) | 1998-11-05 |
NO995246L (en) | 1999-12-28 |
NO995246D0 (en) | 1999-10-27 |
RU2192295C2 (en) | 2002-11-10 |
BR9808107A (en) | 2000-03-08 |
JP2001500529A (en) | 2001-01-16 |
HUP0002344A2 (en) | 2000-12-28 |
PL336631A1 (en) | 2000-07-03 |
FR2762504A1 (en) | 1998-10-30 |
IL131961A0 (en) | 2001-03-19 |
AU728499B2 (en) | 2001-01-11 |
CN1253486A (en) | 2000-05-17 |
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