Connect public, paid and private patent data with Google Patents Public Datasets

Detachable endovascular occlusion device activated by alternating electric current

Download PDF

Info

Publication number
US5976131A
US5976131A US08666804 US66680496A US5976131A US 5976131 A US5976131 A US 5976131A US 08666804 US08666804 US 08666804 US 66680496 A US66680496 A US 66680496A US 5976131 A US5976131 A US 5976131A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
coil
current
occlusion
alternating
detachable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US08666804
Inventor
Guido Guglielmi
Cheng Ji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205Introduction devices
    • A61B2017/12054Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12063Details concerning the detachment of the occluding device from the introduction device electrolytically detachable

Abstract

An apparatus is provided for electrocoagulating blood and tissue at an occlusion site by means of application of an alternating signal or current through a detachable partially insulated coil on the end of a microcatheter. A Guglielmi Detachable Coil (GDC) is preferably used in the combination with damped radio frequency energy to cause local heating at the location of the coil but without local ohmicly heated tissue damage or hot spots. Damping of the radio frequency energy facilitates the avoidance of hot spots. Once carbonization of blood at the detachment zone of the GDC coil occurs, the impedance of the entire system increases. The impedance increase is detected to automatically turn off the alternating current and then to apply a direct current to electrolytically detach the GDC coil from the microcatheter.

Description

This application is a continuation-in-part of U.S. patent application Ser. No. 08/323,662, entitled DETACHABLE ENDOVASCULAR OCCLUSION DEVICE ACTIVATED BY ALTERNATING ELECTRIC CURRENT, filed Oct. 17,1994 which issued as U.S. Pat. No. 5,569,245, which was a continuation-in-part of application Ser. No. 08/311,508 filed Sep. 23, 1994, now U.S. Pat. No. 5,540,680, which in turn was a continuation of application of Ser. No. 07/840,211 filed Feb. 24, 1992 and issued as U.S. Pat. No. 5,354,295, which in turn was a continuation in part of 07/492,717 filed Mar. 13, 1990 which issued as U.S. Pat. No. 5,122,136.

BACKGROUND OF THE INVENTION

1. Field of the Invention

The invention relates to the field of electrocoagulation, and in particular to the use of alternating currents to form endovascular occlusions.

2. Description of the Prior Art

Occlusion of vascular structures by endovascular catheters is currently realized though the use of detachable balloons, injectable glue, detachable or pushable coils, and injectable particles. Detachable balloons are of such a nature that they can only be practically used in large vessels. The use of injectable glue is limited by the difficulty of controllable delivery to the desired occlusion site. Detachable and pushable coils are effective, but in some cases are not sufficiently thrombogenic. The use of injectable particles suffers from their relative invisibility in fluoroscopy and the difficulty in controlling their ultimate disposition at the desired occlusion site. In many prior art technologies the coagulation wire must be ripped out of the clot, usually causing considerable disruption or even reopening the occlusion.

The use of both alternating and direct current for creating electrocoagulation is well known. See, Gold et al., "Transarterial Electrocoagulation Therapy of a Pseudoaneurysm in the Head of the Pancreas, " American Journal of Roentgenology, Volume 125, No. 2, at 422 (1975); Thompson et al., "Vessel Occlusion with Transcatheter Electrocoagulation: Initial Clinical Experience, " Diagnostic Radiology at 335 (November 1979); Thompson et al., "Transcatheter Electrocoagulation: A Therapeutic Angiographic Technique for Vessel Occlusion, " Investigative Radiology at 146 (March-April 1977); Phillips, "Transcatheter Electrocoagulation of Blood Vessels, " Investigative Radiology at 295 (September-October 1973); and Phillips et al., "Experimental Closure of Ateriovenous Fistula by Transcatheter Electrocoagulation," Diagnostic Radiology 115:319 (May 1975). However, each of these experimental investigations were generally performed in larger vessels and did not establish controllability, nor efficacy for use in smaller vessels.

Therefore, what is needed is a clinical occlusive device which is visible, biocompatible, controllable in that it can be detached at will at a desired site even distal to the delivery microcatheter, which is directable, efficacious in coagulating blood and vessel and usable in small vessels without the risk of causing disruption or reopening the occlusion at the end of the treatment.

BRIEF SUMMARY OF THE INVENTION

The invention is an apparatus for selectively providing endovascular occlusion in a patient comprising a delivery wire guidable to or near an endovascular occlusion site. A detachable coil is temporarily and selectively coupled to the delivery wire. An alternating current generator is selectively coupled to the detachable coil for delivering damped RF power signals to the occlusion site. As a result, a controllable occlusive apparatus efficacious and usable in small vessels is provided.

The apparatus further comprises a direct current generator selectively coupled to the detachable coil, and a switch for selectively coupling the alternating current generator and direct current generator to the detachable coil.

The coil is at least partially insulated. The coil has a distal tip and is partially insulated at the distal tip to reduce nonuniform ohmic heating arising from direct contact of the distal tip with tissue at the occlusion site. The coil is selectively insulated to reduce nonuniform ohmic heating arising from direct contact of between the coil and tissue at the occlusion site.

The alternating current and the direct current generators are variably controllable, in addition to which the controllable alternating current generator is frequency controllable.

The apparatus further comprises a sensing circuit for determining when a predetermined state of electrocoagulation is achieved at or near the detachable coil. The sensing circuit senses impedance of the detachable coil within the patient.

The apparatus further comprises a control circuit for selectively initiating detachment of the coil when the sensing circuit determines the predetermined state of electrocoagulation has been achieved.

The alternating current generator serves to ohmicly heat the detachable coil and surrounding blood and tissues,. but local overheating is at least reduced by disposition of an insulator on at least a portion of the coil where the coil directly contacts the tissues. In addition in one embodiment, the alternating current generator serves to dielectricly heat the detachable coil and surrounding blood at a radio frequency.

The invention is also a method of forming a vascular occlusion comprising the steps of providing a conductive delivery wire, disposing a conductive coil coupled to the delivery wire at or near a selected occlusion site, and applying an alternating current to the coil to coagulate the occlusion site without substantial local ohmic heating between contact points between the coil and the occlusion site. A determination is made whether a predetermined amount of electrocoagulation has occurred at the occlusion site. The alternating current through the coil is terminated when the step of determining establishes that the predetermined electrocoagulation has occurred. The coil is detached from the delivery wire to leave the coil at the occlusion site. As a result, an occlusion is efficaciously provided in a small vessel.

In the illustrated embodiment the coil is at least partially insulated to define insulated and noninsulated portions of the coil so that application of the alternating current to the coil is through only the noninsulated portions of the coil. the insulated portions selected to include at least one of the contact points.

Similarly, the invention is defined as a method of forming a vascular occlusion comprising the steps of providing a conductive delivery wire and disposing a conductive coil coupled to the delivery wire at or near a selected occlusion site. A damped alternating current is applied to the coil to coagulate the occlusion site. A determination is made whether a predetermined amount of electrocoagulation has occurred at the occlusion site. The alternating current through the coil is terminated when the step of determining establishes that the predetermined electrocoagulation has occurred. The coil is detached from the delivery wire to leave the coil at the occlusion site. As a result, an occlusion is efficaciously provided in a small vessel. The damped alternating current is applied to the coil to coagulate the occlusion site in a manner to reduce ohmic heating damage to or hot spots at the occlusion site.

The invention is still further defined as an occluding device comprising an elongated body member having a proximal end, a distal end, and a body length between the proximal and distal ends. A detachable joint is attached to the proximal end of the body member. The joint is capable of conducting an electrical current to the body member. The body member is comprised of at least a proximal conductive region comprising a conductive material and a distal insulated region having a length between about 5 and 25% of the body length.

The body member may take the form of a helically wound coil. The insulated distal end or the distal insulated region may be comprised of an insulator, or the insulated region may be comprised of a core of a conductive material and an insulated covering.

The invention may be better visualized by now turning to the following drawings wherein like elements are referenced by like numerals.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is an idealized diagram of the apparatus of the invention.

FIG. 2 is an enlarged view of one embodiment of the catheter for use in connection with the apparatus of FIG. 1.

FIG. 3 is a second embodiment of the catheter tip used in connection with the apparatus of FIG. 1.

FIG. 4 is a waveform diagram of damped RF excitation applied to the coil of the invention.

The invention and its various embodiments may now be better understood by turning to the following detailed description.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

An apparatus is provided for electrocoagulating blood and tissue at an occlusion site by means of application of an alternating signal or current through a detachable partially insulated coil on the end of a microcatheter. A Guglielmi Detachable Coil (GDC) is preferably used in the combination with damped radio frequency energy to cause local heating at the location of the coil but without local ohmicly heated tissue damage or hot spots. Damping of the radio frequency energy facilitates the avoidance of hot spots. Once carbonization of blood at the detachment zone of the GDC coil occurs, the impedance of the entire system increases. The impedance increase is detected to automatically turn off the alternating current and then to apply a direct current to electrolytically detach the GDC coil from the microcatheter.

The apparatus of the invention uses a detachable microcatheter coil system and a source of alternating and direct electric current. The electrolytically detachable coil system is commercialized by Target Therapeutics of California as the Guglielmi Detachable Coil System (hereinafter defined as the GDC coil or system) and includes a source of direct current coupled to a microcatheter-guided wire with an electrolytically detachable distal coil. Any one of the embodiments described in U.S. Pat. Nos. 5,122,136; 5,226,911; and/or 5,354,295 may be used in the present apparatus. All of the U.S. Pat. Nos. 5,122,136; 5,226,911; and 5,354,295 are incorporated herein by reference as if set forth in their entirety. Mechanical means for detachment of the coil from the catheter is disclosed in U.S. Pat. Nos. 5,234,437 and 5,261,916 also incorporated herein by reference. The invention includes the use of not only GDC coils, but any type of detachable coil including those detachable by mechanical, thermal, optical, electrical, electromagnetic means or combinations of these various means.

FIG. 1 is a highly diagrammatic depiction of the apparatus as applied to form an endovascular occlusion. The GDC system, generally denoted by reference numeral 10, includes a guidable microcatheter 12, which in the illustrated embodiment is a tracker endovascular catheter as manufactured by Target Therapeutics, Inc. of Fremont, Calif. A GDC coil 14 is positioned at or proximate to a selected occlusion site 16, which is typically in a small vessel. GDC coil 14 is generally fabricated from platinum and may assume any physical shape, form or composition described in the foregoing incorporated patent references or known in the art. For example, GDC coil 14 may be straight, curved, circular, spiral, biased to form a preferred shaped, or completely limp and pliable, and may incorporate fibers or other equivalent micro-obstructive structures. The apparatus of FIG. 1 is particularly useful for arterial feeder occlusion of arteriovenous malformations, arteriovenous fistulae and vascular tumors.

For example, in the embodiment of FIG. 2, microcatheter 12 is shown as carrying an insulated guidewire 18 extending from catheter tip 20. At a predetermined position, insulated guidewire 18 is stripped of its insulation to provide a bare wire 22 connected at junction 24 to GDC coil 14.

GDC coil 14 is positioned at or near site 16 and an alternating signal generator 26 is connected through switching circuit 28 to a proximal end of delivery wire 22. As is conventional in the art, the alternating current is applied at a frequency, voltage, current repetition time, wave shape and other signal characteristic as may be desired to induce electrocoagulation of blood and body tissue in contact with and in the immediate vicinity of the noninsulated exposed portion of GDC coil 14 and wire 22 at the distal end of microcatheter 12. No electrocoagulation occurs in contact with or in the immediate vicinity of the insulated portion 18 of delivery wire 22.

A ground electrode 30 is provided to the patient through means of a conductive dermal adhesive pad, symbolically shown in FIG. 1 schematically as an electrical ground 30. The alternating signal or current applied through GDC coil 14 induces heating in the proximity of the noninsulated platinum portion of the GDC coil and/or the tissue such as the arterial or vessel wall and blood surrounding GDC coil 14. The insulated portion of the delivery wire should extend to almost 0.5 mm of the solder joint 24 holding coil 14, so that when alternating current or RF is applied, a clot will form substantially only around the detachable coil 14 and not the delivery wire. The frequency which is contemplated as being used and the present apparatus includes very low frequencies just above direct current to radio frequencies spanning the spectrum from less than 1 Hertz to many Gigahertz. For example, a frequency can be chosen to match a radio frequency absorption peak for any of the constituents at occlusion site 16, such as water. The proteins of the vascular structure or the blood are denatured by the heat and the shrinkage of the vascular wall and/or clotting of blood will occur. For example, it is well known that collagen fibers in the vascular wall are shrinkable at temperatures above 60 degrees centigrade.

An alternative embodiment is illustrated in FIG. 3 which is identical to that of FIG. 2 except that coil 14 is all or partially insulated. In the illustration of FIG. 3 the distal tip portion 42 is insulated by a plastic encapsulation 40. Alternatively, tip portion 42 may be provided with a thin film insulation conforming to the helical shape of coil 14 to leave tip portion 42 in substantially the same condition with respect to flexibility or stiffness as the remaining noninsulated portion of coil 14. The purpose of insulation 40 in whatever form it takes is to provide electrical insulation between coil 14 and the body tissues. In some cases depending on frequency and power levels, the possibility for tissue damage may occur if significant ohmic heating is established in the tissue through current delivered to the tissue through a contacting portion of coil 14. Typically, the distal tip portion 42 of coil 14 may physically contact the surrounding tissue making a path of least resistance of the current into the tissue and therefore concentrating current flow at that point. The ohmic heating then in the tissue can in some cases become concentrated at this point with the potential for tissue damage or at least nonuniform coagulation. Therefore, it is within the scope of contemplation of the invention that more than just the tip portion 42 of coil 14 may be insulated or partially insulated. For example, tip portion 42 may have a coating of very high resistivity while the remaining portion of coil 14 may have a coating of substantially lower resistivity. Striated insulation may also be employed to selectively control the size of the direct electrical contact area of coil 14 at different longitudinal points on coil 14 with the surrounding tissue, fluid or blood.

The power provided by alternating signal generator 26 is variable by the operator through an interface unit 32 coupled thereto either directly or through switching circuit 28. Variability of the power, the voltage, current and repetition rate through interface 32 of the output of alternating current generator 26 is used to achieve vascular occlusion without damaging the vessel wall, and to minimize or even substantially avoid unintended or unwanted heating of the surrounding tissues. Alternating signal generator 26 is a variable alternating current generator with a voltage in the range of 0 to 3000 volts. The generator is battery operated with rechargeable batteries or operated off line voltage. The waveform shape is selectable through interface 32 and typically may be sine wave, square wave, triangular wave or customized shapes with a variable frequency or pulse rate.

The RF waveform applied to coil 14 may be modulated in any manner now known or later devised to selectively control the power or rate of change at which power is delivered by coil 14 into the tissue. For example, the RF waveform may be controllably damped as shown in FIG. 4 so that the energy input by each pulse into the tissue is delivered at an instantaneous rate which allows for heat dissipation to avoid or lessen tissue damage to ohmic heating. While thermal dissipation time constants in tissue are generally much slower than any of the time parameters of the RF envelope, and while it is not completely understood why damped RF waveforms are less likely to damage tissue in the context of an endovascular heating coil, the fact has been observed.

The waveform of the alternating current signal is continuously monitored through interface 32 and vessel occlusion is instantly detected by changes in the shape of the waveform due to carbonization of the blood on the detachment zone in the proximity of junction 24 on GDC coil 14. This waveform change due to blood carbonization is determined by a change in the impedance of the system shown in FIG. 1. Therefore, interface 32 is contemplated as included an impedance detector which will automatically sound an audible signal to the operator or trigger an automatic turn off of the alternating current generator 26. Once sufficient coagulation has been determined to have occurred, GDC coil 14 is detached as described in the incorporated patent references by means of a direct current generated by direct current generator 34 and coupled through switching circuit 28 to delivery wire 22. Switching circuit 28 may be manually activated by the operator, or automatically programmed to switch over to deliver the proper direct current separating current at the completion of alternating current electrocoagulation.

GDC coils 14 are particularly effective in the apparatus of FIG. 1. In contrast to other types of endovascular coils, GDC coils 14 are detachable in place and distal from delivery catheter 12 after vessel occlusion has been achieved. Coils of various sizes, ranging from 0.005 to 0.2 inch in diameter, various shapes and configurations and softness utilizing metallic or conductive wire diameters in the range of 0.001 to 0.004 or more inch can be used as desired for coil 14. Conductive wires with different electrical resistances may be utilized. Platinum wire is preferred, but any conductor, including nonmetallic conductors can be substituted.

Although the embodiment of FIG. 1 has been shown with alternating current generator 26 and direct current generator 34 as separate units, it is expressly contemplated that both units, as well as interface 32 together with an impedance detection circuit as described above, will be integrally incorporated within a single circuit. The impedance detector subcircuit thus automatically will turn off the alternating current signal and activate the direct current signal to detach the GDC coil 14. In this embodiment, the operator, after setting the initial parameters, need only then to turn on a single activate switch to cycle through a complete procedure. Acoustic or audio visual feedback can be provided to display both alternating current vessel occlusion and detachment of GDC coil 14. For example, both the direct current and alternating current components of the signal may be digitally generated through a personal computer software controlled interface. Power levels are low, being typically in the range of 0.1 to 20 watts so that the use of broadband generators is feasible. Alternatively, interface 32 may be used to selectively couple two or more separate generators to catheter 12 to completely cover the desire frequency bands discussed above.

While a conventional guidewire 22 is adequate for transmission of direct current to MHz signals, it is conceivable that power losses at higher frequencies in the GHz bands may become unacceptable. Therefore, guidewire 22 in these cases may be alternatively fabricated in the form of a flexible micro-coaxial cable, microwave transmission stripline or other transmission means now known or later devised as may be appropriate for carrying the power levels and frequencies disclosed.

Many alterations and modifications may be made by those having ordinary skill in the art without departing from the spirit and scope of the invention. Therefore, it must be understood that the illustrated embodiment has been set forth only for the purposes of example and that it should not be taken as limiting the invention as defined by the following claims.

The words used in this specification to describe the invention and its various embodiments are to be understood not only in the sense of their commonly defined meanings, but to include by special definition structure, material or acts beyond the scope of the commonly defined meanings. The definitions of the words or elements of the following claims are, therefore, defined in this specification to include not only the combination of elements which are literally set forth, but all equivalent structure, material or acts for performing substantially the same function in substantially the same way to obtain substantially the same result.

In addition to the equivalents of the claimed elements, obvious substitutions now or later known to one with ordinary skill in the art are defined to be within the scope of the defined elements.

The claims are thus to be understood to include what is specifically illustrated and described above, what is conceptionally equivalent, what can be obviously substituted and also what essentially incorporates the essential idea of the invention.

Claims (26)

We claim:
1. An apparatus for selectively providing endovascular occlusion in a patient comprising:
a delivery wire guidable to or near an endovascular occlusion site;
a detachable conductive coil temporarily and selectively coupled to said delivery wire; and
an alternating current generator selectively coupled to said detachable coil for delivering damped RF power signals to said occlusion site,
whereby a controllable occlusive apparatus efficacious and usable in small vessels is provided.
2. The apparatus of claim 1 further comprising:
a direct current generator selectively coupled to said detachable coil; and
a switch for selectively coupling said alternating current generator and direct current generator to said detachable coil.
3. The apparatus of claim 2 wherein said coil has a distal tip and is partially insulated at said distal tip to reduce nonuniform ohmic heating arising from direct contact of said distal tip with tissue at said occlusion site.
4. The apparatus of claim 2 wherein said direct current generator is variably controllable.
5. The apparatus of claim 2 wherein said alternating and direct current generators are variably controllable.
6. The apparatus of claim 1 wherein said coil is at least partially insulated.
7. The apparatus of claim 1 wherein said coil is selectively insulated to reduce nonuniform ohmic heating arising from direct contact between said coil and tissue at said occlusion site.
8. The apparatus of claim 1 wherein said alternating current generator is variably controllable.
9. The apparatus of claim 6 wherein said controllable alternating current generator is frequency controllable.
10. The apparatus of claim 1 further comprising a sensing circuit for determining when a predetermined state of electrocoagulation is achieved at or near said detachable coil.
11. The apparatus of claim 10 wherein said sensing circuit senses impedance of said detachable coil within said patient.
12. The apparatus of claim 10 further comprising a control circuit for selectively initiating detachment of said coil when said sensing circuit determines said predetermined state of electrocoagulation has been achieved.
13. The apparatus of claim 1 further comprising an insulator and wherein said alternating current generator serves to ohmicly heat said detachable coil and surrounding blood and tissues, but wherein local overheating is at least reduced by disposition of said insulator on at least a portion of said coil where said coil directly contacts said tissues.
14. The apparatus of claim 1 wherein said alternating current generator serves to dielectricly heat said detachable coil and surrounding blood at a radio frequency.
15. The device of claim 1 where said detachable conductive coil includes a mechanical coupling with said delivery wire and is mechanically temporarily and selectively decoupled from said delivery wire.
16. The device of claim 1 where said detachable conductive coil includes a thermally responsive coupling with said delivery wire and is temporarily and selectively decoupled from said delivery wire by use of thermal energy.
17. The device of claim 1 where said detachable conductive coil includes a optically responsive coupling with said delivery wire and is temporarily and selectively decoupled from said delivery wire by use of optical energy.
18. The device of claim 1 where said detachable conductive coil includes an electrically responsive coupling with said delivery wire and is temporarily and selectively decoupled from said delivery wire by use of electrical energy.
19. The device of claim 1 where said detachable conductive coil includes an electromagnetically responsive coupling with said delivery wire and is temporarily and selectively decoupled from said delivery wire by use of electromagnetic energy.
20. An apparatus for selectively providing endovascular occlusion in a patient comprising:
a delivery wire guidable to or near an endovascular occlusion site;
a detachable conductive coil temporarily and selectively coupled to said delivery wire, said coil being at least partially insulated to at least reduce local ohmic heating at points of contact between said coil and surrounding tissue at said occlusion site; and
an alternating current generator selectively coupled to said detachable coil for delivering RF power signals to said occlusion site, wherein said alternating current generator is a radio frequency generator which generates damped radio frequency power signals,
whereby a controllable occlusive apparatus efficacious and usable in small vessels is provided.
21. The apparatus of claim 20 further comprising a control circuit for determining when a predetermined degree of electrocoagulation has occurred at said coil and then for detaching said coil from said delivery wire.
22. An apparatus for selectively providing endovascular occlusion in a patient comprising:
a delivery wire guidable to or near an endovascular occlusion site;
a detachable conductive coil temporarily and selectively coupled to said delivery wire, said coil being at least partially insulated to at least reduce local ohmic heating at points of contact between said coil and surrounding tissue at said occlusion site; and
an alternating current generator selectively coupled to said detachable coil for delivering RF power signals to said occlusion site,
a direct current signal source electrically coupled to said detachable coil and wherein said control circuit turns said alternating current generator off when said predetermined degree of electrocoagulation has occurred and turns said direct current signal source on to detach said coil from said delivery wire,
whereby a controllable occlusive apparatus efficacious and usable in small vessels is provided.
23. A method of forming a vascular occlusion comprising:
providing a conductive delivery wire;
disposing a conductive coil coupled to said delivery wire at or near a selected occlusion site;
applying an alternating current to said coil to coagulate said occlusion site without substantial local ohmic heating between contact points between said coil and said occlusion site;
determining whether a predetermined amount of electrocoagulation has occurred at said occlusion site;
terminating said alternating current through said coil when said predetermined amount of electrocoagulation has occurred; and
detaching said coil from said delivery wire to leave said coil at said occlusion site,
whereby an occlusion is efficaciously provided in a small vessel.
24. The method of claim 23 where said coil is at least partially insulated to define insulated and noninsulated portions of said coil so that application of said alternating current to said coil is through only said noninsulated portions of said coil, said insulated portions selected to include at least one of said contact points.
25. A method of forming a vascular occlusion comprising:
providing a conductive delivery wire;
disposing a conductive coil coupled to said delivery wire at or near a selected occlusion site;
applying a damped alternating current to said coil to coagulate said occlusion site;
determining whether a predetermined amount of electrocoagulation has occurred at said occlusion site;
terminating said alternating current through said coil when said step of determining establishes that said predetermined electrocoagulation has occurred; and
detaching said coil from said delivery wire to leave said coil at said occlusion site,
whereby an occlusion is efficaciously provided in a small vessel.
26. The method of claim 25 where said damped alternating current is applied to said coil to coagulate said occlusion site in a manner to reduce ohmic heating damage to said occlusion site.
US08666804 1990-03-13 1996-06-18 Detachable endovascular occlusion device activated by alternating electric current Expired - Lifetime US5976131A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US07492717 US5122136A (en) 1990-03-13 1990-03-13 Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US07840211 US5354295A (en) 1990-03-13 1992-02-24 In an endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US08311508 US5540680A (en) 1990-03-13 1994-09-23 Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US08323662 US5569245A (en) 1990-03-13 1994-10-17 Detachable endovascular occlusion device activated by alternating electric current
US08666804 US5976131A (en) 1990-03-13 1996-06-18 Detachable endovascular occlusion device activated by alternating electric current

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08666804 US5976131A (en) 1990-03-13 1996-06-18 Detachable endovascular occlusion device activated by alternating electric current

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US08323662 Continuation-In-Part US5569245A (en) 1990-03-13 1994-10-17 Detachable endovascular occlusion device activated by alternating electric current

Publications (1)

Publication Number Publication Date
US5976131A true US5976131A (en) 1999-11-02

Family

ID=27502011

Family Applications (1)

Application Number Title Priority Date Filing Date
US08666804 Expired - Lifetime US5976131A (en) 1990-03-13 1996-06-18 Detachable endovascular occlusion device activated by alternating electric current

Country Status (1)

Country Link
US (1) US5976131A (en)

Cited By (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159206A (en) * 1997-10-30 2000-12-12 Kaneka Medix Corporation Medical implement for depositing implanted device and method of depositing implanted device
US6224610B1 (en) 1998-08-31 2001-05-01 Micrus Corporation Shape memory polymer intravascular delivery system with heat transfer medium
US6500149B2 (en) 1998-08-31 2002-12-31 Deepak Gandhi Apparatus for deployment of micro-coil using a catheter
US6527790B2 (en) 2000-12-07 2003-03-04 Scimed Life Systems, Inc. Intravascular balloon catheter for embolic coil delivery
US20050149108A1 (en) * 2003-12-17 2005-07-07 Microvention, Inc. Implant delivery and detachment system and method
US20060030849A1 (en) * 2004-08-05 2006-02-09 Vnus Medical Technologies, Inc. Methods and apparatus for coagulating and/or constricting hollow anatomical structures
US20060052815A1 (en) * 2004-08-25 2006-03-09 Microvention, Inc. Thermal detachment system for implantable devices
US20060189979A1 (en) * 2005-02-23 2006-08-24 Esch Brady D Methods and apparatus for coagulating and/or constricting hollow anatomical structures
US20060271086A1 (en) * 2005-05-31 2006-11-30 Kamal Ramzipoor Stretch-resistant vaso-occlusive devices with flexible detachment junctions
US20060271097A1 (en) * 2005-05-31 2006-11-30 Kamal Ramzipoor Electrolytically detachable implantable devices
US20070239193A1 (en) * 2006-04-05 2007-10-11 Boston Scientific Scimed, Inc. Stretch-resistant vaso-occlusive devices with distal anchor link
US20080287982A1 (en) * 2007-05-16 2008-11-20 Boston Scientific Scimed, Inc. Catheters for electrolytically detachable embolic devices
US20090177261A1 (en) * 2008-01-04 2009-07-09 Boston Scientific Scimed, Inc. Detachment mechanisms for implantable devices
US20090182332A1 (en) * 2008-01-15 2009-07-16 Ethicon Endo-Surgery, Inc. In-line electrosurgical forceps
US20090306701A1 (en) * 2008-06-10 2009-12-10 Boston Scientific Scimed, Inc. Vascular access sheath with integrated return electrode
US20090318990A1 (en) * 2008-06-19 2009-12-24 Tomaschko Daniel K Pacing catheter with expandable distal end
US20100063572A1 (en) * 2008-09-09 2010-03-11 Boston Scientific Scimed, Inc. Composite detachment mechanisms
US20100121350A1 (en) * 2007-04-12 2010-05-13 Greg Mirigian Instantaneous mechanical detachment mechanism for vaso-occlusive devices
US20100137898A1 (en) * 2008-12-02 2010-06-03 Boston Scientific Scimed, Inc. Vaso-occlusive devices with attachment assemblies for stretch-resistant members
US20100249774A1 (en) * 2003-06-05 2010-09-30 Dfine, Inc. Polymer composites for biomedical applications and methods of making
US7828793B2 (en) 2005-07-21 2010-11-09 Tyco Healthcare Group, Lp Methods for treating a hollow anatomical structure
WO2011047168A1 (en) 2009-10-14 2011-04-21 Cardiovascular Technologies, Llc Percutaneous transvalvular intraannular band for mitral valve repair
USRE42625E1 (en) 1990-03-13 2011-08-16 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
USRE42662E1 (en) 1990-03-13 2011-08-30 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
USRE42756E1 (en) 1990-03-13 2011-09-27 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US8029504B2 (en) 2007-02-15 2011-10-04 Ethicon Endo-Surgery, Inc. Electroporation ablation apparatus, system, and method
US8037591B2 (en) 2009-02-02 2011-10-18 Ethicon Endo-Surgery, Inc. Surgical scissors
US8070759B2 (en) 2008-05-30 2011-12-06 Ethicon Endo-Surgery, Inc. Surgical fastening device
US8075572B2 (en) 2007-04-26 2011-12-13 Ethicon Endo-Surgery, Inc. Surgical suturing apparatus
US8100922B2 (en) 2007-04-27 2012-01-24 Ethicon Endo-Surgery, Inc. Curved needle suturing tool
US8114072B2 (en) 2008-05-30 2012-02-14 Ethicon Endo-Surgery, Inc. Electrical ablation device
US8114119B2 (en) 2008-09-09 2012-02-14 Ethicon Endo-Surgery, Inc. Surgical grasping device
USRE43311E1 (en) * 1997-08-29 2012-04-10 Stryker Corporation Fast-detaching electrically insulated implant
US8157834B2 (en) 2008-11-25 2012-04-17 Ethicon Endo-Surgery, Inc. Rotational coupling device for surgical instrument with flexible actuators
US8172772B2 (en) 2008-12-11 2012-05-08 Ethicon Endo-Surgery, Inc. Specimen retrieval device
US8192480B2 (en) 2007-12-21 2012-06-05 Microvention, Inc. System and method of detecting implant detachment
US8211125B2 (en) 2008-08-15 2012-07-03 Ethicon Endo-Surgery, Inc. Sterile appliance delivery device for endoscopic procedures
US8241204B2 (en) 2008-08-29 2012-08-14 Ethicon Endo-Surgery, Inc. Articulating end cap
US8252057B2 (en) 2009-01-30 2012-08-28 Ethicon Endo-Surgery, Inc. Surgical access device
US8262680B2 (en) 2008-03-10 2012-09-11 Ethicon Endo-Surgery, Inc. Anastomotic device
US8262655B2 (en) 2007-11-21 2012-09-11 Ethicon Endo-Surgery, Inc. Bipolar forceps
US8262563B2 (en) 2008-07-14 2012-09-11 Ethicon Endo-Surgery, Inc. Endoscopic translumenal articulatable steerable overtube
US20120239022A1 (en) * 2009-10-21 2012-09-20 Wolfe Thomas J Electromagnetic pathologic lesion treatment system and method
US8298244B2 (en) 2006-10-26 2012-10-30 Tyco Healtcare Group Lp Intracorporeal grasping device
US8317806B2 (en) 2008-05-30 2012-11-27 Ethicon Endo-Surgery, Inc. Endoscopic suturing tension controlling and indication devices
US8328860B2 (en) 2007-03-13 2012-12-11 Covidien Lp Implant including a coil and a stretch-resistant member
US8337394B2 (en) 2008-10-01 2012-12-25 Ethicon Endo-Surgery, Inc. Overtube with expandable tip
US8353487B2 (en) 2009-12-17 2013-01-15 Ethicon Endo-Surgery, Inc. User interface support devices for endoscopic surgical instruments
US8361112B2 (en) 2008-06-27 2013-01-29 Ethicon Endo-Surgery, Inc. Surgical suture arrangement
US8403926B2 (en) 2008-06-05 2013-03-26 Ethicon Endo-Surgery, Inc. Manually articulating devices
US8409200B2 (en) 2008-09-03 2013-04-02 Ethicon Endo-Surgery, Inc. Surgical grasping device
US8457738B2 (en) 2008-06-19 2013-06-04 Cardiac Pacemakers, Inc. Pacing catheter for access to multiple vessels
US8480689B2 (en) 2008-09-02 2013-07-09 Ethicon Endo-Surgery, Inc. Suturing device
US8480657B2 (en) 2007-10-31 2013-07-09 Ethicon Endo-Surgery, Inc. Detachable distal overtube section and methods for forming a sealable opening in the wall of an organ
US8496574B2 (en) 2009-12-17 2013-07-30 Ethicon Endo-Surgery, Inc. Selectively positionable camera for surgical guide tube assembly
US8506564B2 (en) 2009-12-18 2013-08-13 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US8529563B2 (en) 2008-08-25 2013-09-10 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US8568410B2 (en) 2007-08-31 2013-10-29 Ethicon Endo-Surgery, Inc. Electrical ablation surgical instruments
US8579897B2 (en) 2007-11-21 2013-11-12 Ethicon Endo-Surgery, Inc. Bipolar forceps
US8608652B2 (en) 2009-11-05 2013-12-17 Ethicon Endo-Surgery, Inc. Vaginal entry surgical devices, kit, system, and method
US8632584B2 (en) 2002-07-19 2014-01-21 Dendron Gmbh Medical implant having a curlable matrix structure and method of use
US8652150B2 (en) 2008-05-30 2014-02-18 Ethicon Endo-Surgery, Inc. Multifunction surgical device
US8679142B2 (en) 2008-02-22 2014-03-25 Covidien Lp Methods and apparatus for flow restoration
US8679003B2 (en) 2008-05-30 2014-03-25 Ethicon Endo-Surgery, Inc. Surgical device and endoscope including same
US8771260B2 (en) 2008-05-30 2014-07-08 Ethicon Endo-Surgery, Inc. Actuating and articulating surgical device
US8777979B2 (en) 2006-04-17 2014-07-15 Covidien Lp System and method for mechanically positioning intravascular implants
US8777978B2 (en) 2006-04-17 2014-07-15 Covidien Lp System and method for mechanically positioning intravascular implants
US8801747B2 (en) 2007-03-13 2014-08-12 Covidien Lp Implant, a mandrel, and a method of forming an implant
US8828031B2 (en) 2009-01-12 2014-09-09 Ethicon Endo-Surgery, Inc. Apparatus for forming an anastomosis
US8888792B2 (en) 2008-07-14 2014-11-18 Ethicon Endo-Surgery, Inc. Tissue apposition clip application devices and methods
US8906035B2 (en) 2008-06-04 2014-12-09 Ethicon Endo-Surgery, Inc. Endoscopic drop off bag
US8932317B2 (en) 1999-06-02 2015-01-13 Microvention, Inc. Intracorporeal occlusive device and method
US8936631B2 (en) 2010-01-04 2015-01-20 Covidien Lp Apparatus and methods for treating hollow anatomical structures
US8939897B2 (en) 2007-10-31 2015-01-27 Ethicon Endo-Surgery, Inc. Methods for closing a gastrotomy
US8986199B2 (en) 2012-02-17 2015-03-24 Ethicon Endo-Surgery, Inc. Apparatus and methods for cleaning the lens of an endoscope
US9005198B2 (en) 2010-01-29 2015-04-14 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US9011480B2 (en) 2012-01-20 2015-04-21 Covidien Lp Aneurysm treatment coils
US9011431B2 (en) 2009-01-12 2015-04-21 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US9028483B2 (en) 2009-12-18 2015-05-12 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US9039749B2 (en) 2010-10-01 2015-05-26 Covidien Lp Methods and apparatuses for flow restoration and implanting members in the human body
US9050095B2 (en) 2004-09-22 2015-06-09 Covidien Lp Medical implant
US9049987B2 (en) 2011-03-17 2015-06-09 Ethicon Endo-Surgery, Inc. Hand held surgical device for manipulating an internal magnet assembly within a patient
US20150174370A1 (en) * 2013-12-20 2015-06-25 Microvention, Inc. Electrically-Responsive Hydrogels
US9078662B2 (en) 2012-07-03 2015-07-14 Ethicon Endo-Surgery, Inc. Endoscopic cap electrode and method for using the same
US9198665B2 (en) 2004-09-22 2015-12-01 Covidien Lp Micro-spiral implantation device
US9226772B2 (en) 2009-01-30 2016-01-05 Ethicon Endo-Surgery, Inc. Surgical device
US9233241B2 (en) 2011-02-28 2016-01-12 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9242070B2 (en) 2007-12-21 2016-01-26 MicronVention, Inc. System and method for locating detachment zone of a detachable implant
US9254169B2 (en) 2011-02-28 2016-02-09 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9277957B2 (en) 2012-08-15 2016-03-08 Ethicon Endo-Surgery, Inc. Electrosurgical devices and methods
US9314620B2 (en) 2011-02-28 2016-04-19 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
WO2016070147A1 (en) 2014-10-31 2016-05-06 Cerevasc, Llc Methods and systems for treating hydrocephalus
US9427255B2 (en) 2012-05-14 2016-08-30 Ethicon Endo-Surgery, Inc. Apparatus for introducing a steerable camera assembly into a patient
US9545290B2 (en) 2012-07-30 2017-01-17 Ethicon Endo-Surgery, Inc. Needle probe guide
US9561125B2 (en) 2010-04-14 2017-02-07 Microvention, Inc. Implant delivery device
US9572623B2 (en) 2012-08-02 2017-02-21 Ethicon Endo-Surgery, Inc. Reusable electrode and disposable sheath
US9579104B2 (en) 2011-11-30 2017-02-28 Covidien Lp Positioning and detaching implants
US9687245B2 (en) 2012-03-23 2017-06-27 Covidien Lp Occlusive devices and methods of use
US9713475B2 (en) 2014-04-18 2017-07-25 Covidien Lp Embolic medical devices
US9737696B2 (en) 2014-01-15 2017-08-22 Tufts Medical Center, Inc. Endovascular cerebrospinal fluid shunt
US9737697B2 (en) 2009-01-29 2017-08-22 Tufts Medical Center, Inc. Endovascular cerebrospinal fluid shunt
US9808599B2 (en) 2013-12-20 2017-11-07 Microvention, Inc. Device delivery system
US9867622B2 (en) 2014-04-11 2018-01-16 Microvention, Inc. Implant delivery system
US9883910B2 (en) 2015-05-14 2018-02-06 Eticon Endo-Surgery, Inc. Hand held surgical device for manipulating an internal magnet assembly within a patient

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5122136A (en) * 1990-03-13 1992-06-16 The Regents Of The University Of California Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5354295A (en) * 1990-03-13 1994-10-11 Target Therapeutics, Inc. In an endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5743905A (en) * 1995-07-07 1998-04-28 Target Therapeutics, Inc. Partially insulated occlusion device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5122136A (en) * 1990-03-13 1992-06-16 The Regents Of The University Of California Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5354295A (en) * 1990-03-13 1994-10-11 Target Therapeutics, Inc. In an endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
US5743905A (en) * 1995-07-07 1998-04-28 Target Therapeutics, Inc. Partially insulated occlusion device

Cited By (151)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE42625E1 (en) 1990-03-13 2011-08-16 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
USRE42756E1 (en) 1990-03-13 2011-09-27 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
USRE42662E1 (en) 1990-03-13 2011-08-30 The Regents Of The University Of California Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas
USRE43311E1 (en) * 1997-08-29 2012-04-10 Stryker Corporation Fast-detaching electrically insulated implant
US6159206A (en) * 1997-10-30 2000-12-12 Kaneka Medix Corporation Medical implement for depositing implanted device and method of depositing implanted device
US6500149B2 (en) 1998-08-31 2002-12-31 Deepak Gandhi Apparatus for deployment of micro-coil using a catheter
US6224610B1 (en) 1998-08-31 2001-05-01 Micrus Corporation Shape memory polymer intravascular delivery system with heat transfer medium
US8932317B2 (en) 1999-06-02 2015-01-13 Microvention, Inc. Intracorporeal occlusive device and method
US9526505B2 (en) 1999-06-02 2016-12-27 Microvention, Inc. Intracorporeal occlusive device and method
US9788840B2 (en) 1999-06-02 2017-10-17 Michael P. Marks Intracorporeal occlusive device and method
US6527790B2 (en) 2000-12-07 2003-03-04 Scimed Life Systems, Inc. Intravascular balloon catheter for embolic coil delivery
US8632584B2 (en) 2002-07-19 2014-01-21 Dendron Gmbh Medical implant having a curlable matrix structure and method of use
US8657816B2 (en) 2003-06-05 2014-02-25 Dfine, Inc. Polymer composites for biomedical applications and methods of making
US20100249774A1 (en) * 2003-06-05 2010-09-30 Dfine, Inc. Polymer composites for biomedical applications and methods of making
US8771265B2 (en) 2003-06-05 2014-07-08 Dfine, Inc. Polymer composites for biomedical applications and methods of making
US20100249767A1 (en) * 2003-06-05 2010-09-30 Dfine, Inc. Polymer composites for biomedical applications and methods of making
US20050149108A1 (en) * 2003-12-17 2005-07-07 Microvention, Inc. Implant delivery and detachment system and method
US8357157B2 (en) 2004-08-05 2013-01-22 Covidien Lp Methods and apparatus for coagulating and/or constricting hollow anatomical structures
US7824408B2 (en) 2004-08-05 2010-11-02 Tyco Healthcare Group, Lp Methods and apparatus for coagulating and/or constricting hollow anatomical structures
US8083738B2 (en) 2004-08-05 2011-12-27 Tyco Healthcare Group Lp Method and apparatus for coagulating and/or constricting hollow anatomical structures
US8721639B2 (en) 2004-08-05 2014-05-13 Covidien Lp Methods and apparatus for coagulating and/or constricting hollow anatomical structures
US20060030849A1 (en) * 2004-08-05 2006-02-09 Vnus Medical Technologies, Inc. Methods and apparatus for coagulating and/or constricting hollow anatomical structures
US8182506B2 (en) 2004-08-25 2012-05-22 Microvention, Inc. Thermal detachment system for implantable devices
US20060052815A1 (en) * 2004-08-25 2006-03-09 Microvention, Inc. Thermal detachment system for implantable devices
WO2006024040A3 (en) * 2004-08-25 2009-04-09 Microvention Inc Thermal detachment system for implantable devices
US9198665B2 (en) 2004-09-22 2015-12-01 Covidien Lp Micro-spiral implantation device
US9050095B2 (en) 2004-09-22 2015-06-09 Covidien Lp Medical implant
US8795266B2 (en) 2005-02-23 2014-08-05 Covidien Lp Methods and apparatus for coagulating and/or constricting hollow anatomical structures
US7625372B2 (en) 2005-02-23 2009-12-01 Vnus Medical Technologies, Inc. Methods and apparatus for coagulating and/or constricting hollow anatomical structures
US8361061B2 (en) 2005-02-23 2013-01-29 Covidien Lp Methods and apparatus for coagulating and/or constricting hollow anatomical structures
US20060189979A1 (en) * 2005-02-23 2006-08-24 Esch Brady D Methods and apparatus for coagulating and/or constricting hollow anatomical structures
US20060271086A1 (en) * 2005-05-31 2006-11-30 Kamal Ramzipoor Stretch-resistant vaso-occlusive devices with flexible detachment junctions
US8002789B2 (en) 2005-05-31 2011-08-23 Stryker Corporation Stretch-resistant vaso-occlusive devices with flexible detachment junctions
US20060271097A1 (en) * 2005-05-31 2006-11-30 Kamal Ramzipoor Electrolytically detachable implantable devices
US7963961B2 (en) 2005-07-21 2011-06-21 Tyco Healthcare Group Lp Systems for treating a hollow anatomical structure
US8721634B2 (en) 2005-07-21 2014-05-13 Covidien Lp Apparatus and method for ensuring thermal treatment of a hollow anatomical structure
US8321019B2 (en) 2005-07-21 2012-11-27 Covidien Lp Apparatus and method for ensuring safe operation of a thermal treatment catheter
US7837678B2 (en) 2005-07-21 2010-11-23 Tyco Healthcare Group, Lp Systems for treating a hollow anatomical structure
US8852178B2 (en) 2005-07-21 2014-10-07 Covidien Lp Systems for treating a hollow anatomical structure
US7963962B2 (en) 2005-07-21 2011-06-21 Tyco Healthcare Group Lp Methods for treating a hollow anatomical structure
US7837677B2 (en) 2005-07-21 2010-11-23 Tyco Healthcare Group, Lp Systems for treating a hollow anatomical structure
US8636729B2 (en) 2005-07-21 2014-01-28 Covidien Lp Therapeutic system with energy application device and programmed power delivery
US7828793B2 (en) 2005-07-21 2010-11-09 Tyco Healthcare Group, Lp Methods for treating a hollow anatomical structure
US8043285B2 (en) 2005-07-21 2011-10-25 Tyco Healthcare Group Lp Systems for treating a hollow anatomical structure
US20070239193A1 (en) * 2006-04-05 2007-10-11 Boston Scientific Scimed, Inc. Stretch-resistant vaso-occlusive devices with distal anchor link
US8864790B2 (en) 2006-04-17 2014-10-21 Covidien Lp System and method for mechanically positioning intravascular implants
US8795321B2 (en) 2006-04-17 2014-08-05 Covidien Lp System and method for mechanically positioning intravascular implants
US8777978B2 (en) 2006-04-17 2014-07-15 Covidien Lp System and method for mechanically positioning intravascular implants
US8777979B2 (en) 2006-04-17 2014-07-15 Covidien Lp System and method for mechanically positioning intravascular implants
US8795320B2 (en) 2006-04-17 2014-08-05 Covidien Lp System and method for mechanically positioning intravascular implants
US8298244B2 (en) 2006-10-26 2012-10-30 Tyco Healtcare Group Lp Intracorporeal grasping device
US8029504B2 (en) 2007-02-15 2011-10-04 Ethicon Endo-Surgery, Inc. Electroporation ablation apparatus, system, and method
US9375268B2 (en) 2007-02-15 2016-06-28 Ethicon Endo-Surgery, Inc. Electroporation ablation apparatus, system, and method
US8425505B2 (en) 2007-02-15 2013-04-23 Ethicon Endo-Surgery, Inc. Electroporation ablation apparatus, system, and method
US8449538B2 (en) 2007-02-15 2013-05-28 Ethicon Endo-Surgery, Inc. Electroporation ablation apparatus, system, and method
US8801747B2 (en) 2007-03-13 2014-08-12 Covidien Lp Implant, a mandrel, and a method of forming an implant
US8328860B2 (en) 2007-03-13 2012-12-11 Covidien Lp Implant including a coil and a stretch-resistant member
US9289215B2 (en) 2007-03-13 2016-03-22 Covidien Lp Implant including a coil and a stretch-resistant member
US20100121350A1 (en) * 2007-04-12 2010-05-13 Greg Mirigian Instantaneous mechanical detachment mechanism for vaso-occlusive devices
US8075572B2 (en) 2007-04-26 2011-12-13 Ethicon Endo-Surgery, Inc. Surgical suturing apparatus
US8100922B2 (en) 2007-04-27 2012-01-24 Ethicon Endo-Surgery, Inc. Curved needle suturing tool
US20080287982A1 (en) * 2007-05-16 2008-11-20 Boston Scientific Scimed, Inc. Catheters for electrolytically detachable embolic devices
US8568410B2 (en) 2007-08-31 2013-10-29 Ethicon Endo-Surgery, Inc. Electrical ablation surgical instruments
US8939897B2 (en) 2007-10-31 2015-01-27 Ethicon Endo-Surgery, Inc. Methods for closing a gastrotomy
US8480657B2 (en) 2007-10-31 2013-07-09 Ethicon Endo-Surgery, Inc. Detachable distal overtube section and methods for forming a sealable opening in the wall of an organ
US8579897B2 (en) 2007-11-21 2013-11-12 Ethicon Endo-Surgery, Inc. Bipolar forceps
US8262655B2 (en) 2007-11-21 2012-09-11 Ethicon Endo-Surgery, Inc. Bipolar forceps
US9242070B2 (en) 2007-12-21 2016-01-26 MicronVention, Inc. System and method for locating detachment zone of a detachable implant
US8460332B2 (en) 2007-12-21 2013-06-11 Microvention, Inc. System and method of detecting implant detachment
US8192480B2 (en) 2007-12-21 2012-06-05 Microvention, Inc. System and method of detecting implant detachment
US20090177261A1 (en) * 2008-01-04 2009-07-09 Boston Scientific Scimed, Inc. Detachment mechanisms for implantable devices
US20090182332A1 (en) * 2008-01-15 2009-07-16 Ethicon Endo-Surgery, Inc. In-line electrosurgical forceps
US8679142B2 (en) 2008-02-22 2014-03-25 Covidien Lp Methods and apparatus for flow restoration
US8940003B2 (en) 2008-02-22 2015-01-27 Covidien Lp Methods and apparatus for flow restoration
US9161766B2 (en) 2008-02-22 2015-10-20 Covidien Lp Methods and apparatus for flow restoration
US8262680B2 (en) 2008-03-10 2012-09-11 Ethicon Endo-Surgery, Inc. Anastomotic device
US8652150B2 (en) 2008-05-30 2014-02-18 Ethicon Endo-Surgery, Inc. Multifunction surgical device
US8070759B2 (en) 2008-05-30 2011-12-06 Ethicon Endo-Surgery, Inc. Surgical fastening device
US8771260B2 (en) 2008-05-30 2014-07-08 Ethicon Endo-Surgery, Inc. Actuating and articulating surgical device
US8679003B2 (en) 2008-05-30 2014-03-25 Ethicon Endo-Surgery, Inc. Surgical device and endoscope including same
US8114072B2 (en) 2008-05-30 2012-02-14 Ethicon Endo-Surgery, Inc. Electrical ablation device
US8317806B2 (en) 2008-05-30 2012-11-27 Ethicon Endo-Surgery, Inc. Endoscopic suturing tension controlling and indication devices
US8906035B2 (en) 2008-06-04 2014-12-09 Ethicon Endo-Surgery, Inc. Endoscopic drop off bag
US8403926B2 (en) 2008-06-05 2013-03-26 Ethicon Endo-Surgery, Inc. Manually articulating devices
US20090306701A1 (en) * 2008-06-10 2009-12-10 Boston Scientific Scimed, Inc. Vascular access sheath with integrated return electrode
US9037235B2 (en) * 2008-06-19 2015-05-19 Cardiac Pacemakers, Inc. Pacing catheter with expandable distal end
US8457738B2 (en) 2008-06-19 2013-06-04 Cardiac Pacemakers, Inc. Pacing catheter for access to multiple vessels
US20090318990A1 (en) * 2008-06-19 2009-12-24 Tomaschko Daniel K Pacing catheter with expandable distal end
US8361112B2 (en) 2008-06-27 2013-01-29 Ethicon Endo-Surgery, Inc. Surgical suture arrangement
US8262563B2 (en) 2008-07-14 2012-09-11 Ethicon Endo-Surgery, Inc. Endoscopic translumenal articulatable steerable overtube
US8888792B2 (en) 2008-07-14 2014-11-18 Ethicon Endo-Surgery, Inc. Tissue apposition clip application devices and methods
US8211125B2 (en) 2008-08-15 2012-07-03 Ethicon Endo-Surgery, Inc. Sterile appliance delivery device for endoscopic procedures
US8529563B2 (en) 2008-08-25 2013-09-10 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US8241204B2 (en) 2008-08-29 2012-08-14 Ethicon Endo-Surgery, Inc. Articulating end cap
US8480689B2 (en) 2008-09-02 2013-07-09 Ethicon Endo-Surgery, Inc. Suturing device
US8409200B2 (en) 2008-09-03 2013-04-02 Ethicon Endo-Surgery, Inc. Surgical grasping device
US8940011B2 (en) 2008-09-09 2015-01-27 Boston Scientific Scimed, Inc. Composite detachment mechanisms
EP2859854A1 (en) 2008-09-09 2015-04-15 Boston Scientific Scimed, Inc. Composite detachment mechanism
US20100063572A1 (en) * 2008-09-09 2010-03-11 Boston Scientific Scimed, Inc. Composite detachment mechanisms
US8114119B2 (en) 2008-09-09 2012-02-14 Ethicon Endo-Surgery, Inc. Surgical grasping device
US8337394B2 (en) 2008-10-01 2012-12-25 Ethicon Endo-Surgery, Inc. Overtube with expandable tip
US9220526B2 (en) 2008-11-25 2015-12-29 Ethicon Endo-Surgery, Inc. Rotational coupling device for surgical instrument with flexible actuators
US8157834B2 (en) 2008-11-25 2012-04-17 Ethicon Endo-Surgery, Inc. Rotational coupling device for surgical instrument with flexible actuators
US20100137898A1 (en) * 2008-12-02 2010-06-03 Boston Scientific Scimed, Inc. Vaso-occlusive devices with attachment assemblies for stretch-resistant members
US8172772B2 (en) 2008-12-11 2012-05-08 Ethicon Endo-Surgery, Inc. Specimen retrieval device
US9011431B2 (en) 2009-01-12 2015-04-21 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US8828031B2 (en) 2009-01-12 2014-09-09 Ethicon Endo-Surgery, Inc. Apparatus for forming an anastomosis
US9737697B2 (en) 2009-01-29 2017-08-22 Tufts Medical Center, Inc. Endovascular cerebrospinal fluid shunt
US9226772B2 (en) 2009-01-30 2016-01-05 Ethicon Endo-Surgery, Inc. Surgical device
US8252057B2 (en) 2009-01-30 2012-08-28 Ethicon Endo-Surgery, Inc. Surgical access device
US8037591B2 (en) 2009-02-02 2011-10-18 Ethicon Endo-Surgery, Inc. Surgical scissors
WO2011047168A1 (en) 2009-10-14 2011-04-21 Cardiovascular Technologies, Llc Percutaneous transvalvular intraannular band for mitral valve repair
US20120239022A1 (en) * 2009-10-21 2012-09-20 Wolfe Thomas J Electromagnetic pathologic lesion treatment system and method
US9216299B2 (en) * 2009-10-21 2015-12-22 Thomas J. Wolfe Electromagnetic pathologic lesion treatment system and method
US8608652B2 (en) 2009-11-05 2013-12-17 Ethicon Endo-Surgery, Inc. Vaginal entry surgical devices, kit, system, and method
US8496574B2 (en) 2009-12-17 2013-07-30 Ethicon Endo-Surgery, Inc. Selectively positionable camera for surgical guide tube assembly
US8353487B2 (en) 2009-12-17 2013-01-15 Ethicon Endo-Surgery, Inc. User interface support devices for endoscopic surgical instruments
US9028483B2 (en) 2009-12-18 2015-05-12 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US8506564B2 (en) 2009-12-18 2013-08-13 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US8936631B2 (en) 2010-01-04 2015-01-20 Covidien Lp Apparatus and methods for treating hollow anatomical structures
US9616246B2 (en) 2010-01-04 2017-04-11 Covidien Lp Apparatus and methods for treating hollow anatomical structures
US9005198B2 (en) 2010-01-29 2015-04-14 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US9561125B2 (en) 2010-04-14 2017-02-07 Microvention, Inc. Implant delivery device
US9039749B2 (en) 2010-10-01 2015-05-26 Covidien Lp Methods and apparatuses for flow restoration and implanting members in the human body
US9233241B2 (en) 2011-02-28 2016-01-12 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9254169B2 (en) 2011-02-28 2016-02-09 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9314620B2 (en) 2011-02-28 2016-04-19 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9049987B2 (en) 2011-03-17 2015-06-09 Ethicon Endo-Surgery, Inc. Hand held surgical device for manipulating an internal magnet assembly within a patient
US9579104B2 (en) 2011-11-30 2017-02-28 Covidien Lp Positioning and detaching implants
US9011480B2 (en) 2012-01-20 2015-04-21 Covidien Lp Aneurysm treatment coils
US8986199B2 (en) 2012-02-17 2015-03-24 Ethicon Endo-Surgery, Inc. Apparatus and methods for cleaning the lens of an endoscope
US9687245B2 (en) 2012-03-23 2017-06-27 Covidien Lp Occlusive devices and methods of use
US9427255B2 (en) 2012-05-14 2016-08-30 Ethicon Endo-Surgery, Inc. Apparatus for introducing a steerable camera assembly into a patient
US9078662B2 (en) 2012-07-03 2015-07-14 Ethicon Endo-Surgery, Inc. Endoscopic cap electrode and method for using the same
US9788888B2 (en) 2012-07-03 2017-10-17 Ethicon Endo-Surgery, Inc. Endoscopic cap electrode and method for using the same
US9545290B2 (en) 2012-07-30 2017-01-17 Ethicon Endo-Surgery, Inc. Needle probe guide
US9572623B2 (en) 2012-08-02 2017-02-21 Ethicon Endo-Surgery, Inc. Reusable electrode and disposable sheath
US9277957B2 (en) 2012-08-15 2016-03-08 Ethicon Endo-Surgery, Inc. Electrosurgical devices and methods
US9788885B2 (en) 2012-08-15 2017-10-17 Ethicon Endo-Surgery, Inc. Electrosurgical system energy source
US20150174370A1 (en) * 2013-12-20 2015-06-25 Microvention, Inc. Electrically-Responsive Hydrogels
US9808599B2 (en) 2013-12-20 2017-11-07 Microvention, Inc. Device delivery system
US9737696B2 (en) 2014-01-15 2017-08-22 Tufts Medical Center, Inc. Endovascular cerebrospinal fluid shunt
US9867622B2 (en) 2014-04-11 2018-01-16 Microvention, Inc. Implant delivery system
US9713475B2 (en) 2014-04-18 2017-07-25 Covidien Lp Embolic medical devices
US9669195B2 (en) 2014-10-31 2017-06-06 Cerevasc, Llc Methods and systems for treating hydrocephalus
US9724501B2 (en) 2014-10-31 2017-08-08 Cerevasc, Llc Methods and systems for treating hydrocephalus
US9662479B2 (en) 2014-10-31 2017-05-30 Cerevasc, Llc Methods and systems for treating hydrocephalus
US9387311B1 (en) 2014-10-31 2016-07-12 Cerevasc, Llc Methods and systems for treating hydrocephalus
US9545505B2 (en) 2014-10-31 2017-01-17 Cerevasc, Llc Methods and systems for treating hydrocephalus
WO2016070147A1 (en) 2014-10-31 2016-05-06 Cerevasc, Llc Methods and systems for treating hydrocephalus
US9883910B2 (en) 2015-05-14 2018-02-06 Eticon Endo-Surgery, Inc. Hand held surgical device for manipulating an internal magnet assembly within a patient

Similar Documents

Publication Publication Date Title
US6032077A (en) Ablation catheter with electrical coupling via foam drenched with a conductive fluid
US4492231A (en) Non-sticking electrocautery system and forceps
US5290286A (en) Bipolar instrument utilizing one stationary electrode and one movable electrode
US5249585A (en) Urethral inserted applicator for prostate hyperthermia
US6398780B1 (en) Expandable vein ligator catheter and method of use
US6502575B1 (en) Instrument for interrupting conduction paths within the heart
US7122033B2 (en) Endoluminal radiofrequency cauterization system
US5275597A (en) Percutaneous transluminal catheter and transmitter therefor
US5669907A (en) Plasma enhanced bipolar electrosurgical system
US7048733B2 (en) Surgical perforation device with curve
US5964759A (en) Electroconvergent cautery system
US5643254A (en) Endovascular embolic device detachment detection method
US7407502B2 (en) Radio-frequency generator for powering an ablation device
US5507743A (en) Coiled RF electrode treatment apparatus
US6165172A (en) Expandable vein ligator catheter and method of use
US6033397A (en) Method and apparatus for treating esophageal varices
US6190386B1 (en) Electrosurgical forceps with needle electrodes
US6319251B1 (en) Medical device and methods for treating intravascular restenosis
US20030216729A1 (en) Device and method for wound healing and uses therefor
US5967984A (en) Ultrasound imaging catheter with a cutting element
US4691703A (en) Thermal cautery system
US5540679A (en) Device and method for heating tissue in a patient's body
US5007908A (en) Electrosurgical instrument having needle cutting electrode and spot-coag electrode
US6077261A (en) Device for permanent vessel occlusion
US6063078A (en) Method and apparatus for tissue ablation

Legal Events

Date Code Title Description
AS Assignment

Owner name: REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE, CALI

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GUGLIELMI, GUIDO;JI, CHEN;REEL/FRAME:008068/0296

Effective date: 19960516

FPAY Fee payment

Year of fee payment: 4

REMI Maintenance fee reminder mailed
FPAY Fee payment

Year of fee payment: 8

FPAY Fee payment

Year of fee payment: 12

SULP Surcharge for late payment

Year of fee payment: 11