US5569287A - Means for collecting and spotting small amount of blood - Google Patents

Means for collecting and spotting small amount of blood Download PDF

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Publication number
US5569287A
US5569287A US08/353,108 US35310894A US5569287A US 5569287 A US5569287 A US 5569287A US 35310894 A US35310894 A US 35310894A US 5569287 A US5569287 A US 5569287A
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United States
Prior art keywords
blood
piston
cylinder
needle
puncturing tip
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Expired - Fee Related
Application number
US08/353,108
Inventor
Shigeru Tezuka
Hikaru Tsuruta
Teruaki Koizumi
Masao Kitajima
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Fujifilm Holdings Corp
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Fuji Photo Film Co Ltd
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Assigned to FUJI PHOTO FILM CO., LTD. reassignment FUJI PHOTO FILM CO., LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KITAJIMA, MASAO, KOIZUMI, TERUAKI, TEZUKA, SHIGERU, TSURUTA, HIKARU
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
    • A61B5/15188—Constructional features of reusable driving devices
    • A61B5/15192—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for retracting the lancet unit into the driving device housing
    • A61B5/15194—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for retracting the lancet unit into the driving device housing fully automatically retracted, i.e. the retraction does not require a deliberate action by the user, e.g. by terminating the contact with the patient's skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • A61B5/150435—Specific design of proximal end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150664—Pivotable protective sleeves, i.e. sleeves connected to, or integrated in, the piercing or driving device, and which are pivoted for covering or uncovering the piercing element
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15107—Piercing being assisted by a triggering mechanism
    • A61B5/15111—Semi-automatically triggered, e.g. at the end of the cocking procedure, for instance by biasing the main drive spring or when reaching sufficient contact pressure, the piercing device is automatically triggered without any deliberate action by the user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
    • A61B5/15117—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap

Definitions

  • This invention relates to means for collecting and spotting a small amount of blood.
  • the blood is generally tested.
  • a small but certain amount of blood is required.
  • the blood is taken by an expert such as a medical doctor or a nurse through vein.
  • several drops of blood are taken by slightly injuring a finger tip or an earlobe.
  • multi-layered analytical elements which contain chemical reagents, biochemical reagents, or immunological reagents.
  • a small but predetermined amount of the blood should be spotted onto the analytical element for causing a color development in the element.
  • the developed color is then measured at a predetermined wavelength to quantitatively determine the analyte in the blood.
  • the procedure for collecting the blood is also performed by a patient per se, for checking blood sugar level or cholesterol level by himself.
  • the blood sugar level ought to be checked frequently (for instance, several times a day), though each check procedure requires only a small amount of the blood.
  • the blood is taken at a finger tip, because a great number of blood vessels are gathered at the finger tip.
  • the blood collection at the finger tip sometimes causes acute pain, because a great number of nerves are also gathered at the finger tip.
  • the blood collection at the finger tip is also sometimes troublesome, because the finger tip is frequently used for daily works. For these reasons, the blood collection at other portions is sometimes required.
  • Japanese Patent Provisional Publications No. 62-38140, No. H-1-185245, and No. H-5-95938 describe means for collecting a small amount of blood from a human body with simple operation. These means, however, are not designed for spotting a predetermined amount of the collected blood sample onto an analytical means.
  • the present invention has an object to provide a blood collecting and spotting means which is employable for taking a small amount of blood and spotting a predetermined amount of blood onto an analytical means with little pain and no complicated procedures.
  • the invention also has an object to provide a blood collecting and spotting means which is repeatedly employable with replacement of a needle tip.
  • the present invention resides in a means for collecting and spotting a small amount of blood which comprises a cylinder, a piston, and a puncturing tip, wherein:
  • the piston is inserted airtightly into the upper end of the cylinder;
  • the puncturing tip is airtightly and exchangeably fitted onto the lower end of the cylinder;
  • the puncturing tip comprises a blood conduit and a needle suspended by a spring within the blood conduit;
  • the blood conduit has a volume which is equal to a volume of blood to be spotted to analytical means
  • the needle is arranged to be pushed out from the puncturing tip by descent of the piston and then return back by ascent of the piston.
  • FIG. 1 illustrates an example of the means for collecting and spotting a small amount of blood according to the invention, by separating the cylinder portion and puncturing tip.
  • FIG. 2 illustrates the blood collecting and spotting means of FIG. 1 under the condition that the sliding means is pushed in and fixed and the puncturing tip is fitted to the cylinder.
  • FIG. 3 illustrates the blood collecting and spotting means of FIG. 2 under the condition that the piston is pushed down, the sliding means is slide down and then the needle is pushed down to be inserted into a part of human body through skin.
  • FIG. 4 illustrates the blood collecting and spotting means of FIG. 3 under the condition that the piston is returned to the original position, the sliding means is slide up, the needle is pushed up by the action of the spring, and then blood is taken out to fill up the blood conduit. An excess of the taken blood is received in a blood receiver of the puncturing tip.
  • FIG. 5 illustrates the blood collecting and spotting means of FIG. 4 under the condition that the piston is again pushed down, the sliding means is slide down, and then a blood is pushed down to be spotted onto an analytical means (not shown).
  • FIG. 6 illustrates another example of the puncturing tip to be attached to the blood collecting and spotting means of the invention.
  • FIG. 7 illustrates a top view of the spring means for suspending the needle shown in FIG. 6.
  • FIG. 8 illustrates a lower portion of the blood collecting and spotting means of FIG. 6 under the condition that the needle is inserted into a part of human body.
  • an example of the blood collecting and spotting means 1 comprises a main body 100 and a puncturing tip 200.
  • the main body 100 is composed of a cylinder 110, a piston 120, and a sliding means 130.
  • the cylinder 110 has a tapered cylinder portion 112 at the lower end of the cylindrical portion 111 and two flanges 113, 113' at the upper end.
  • the piston 120 is inserted into the cylinder 110 under such condition that the piston 120 is able to descend and ascend within the cylinder 110.
  • the puncturing tip 200 has a cylindrical body 201 whose opened upper end 202 is so tapered that the tip is airtightly and exchangeably fitted to the tapered cylinder portion 112 of the cylinder 110.
  • the puncturing tip 200 further has a lower portion 204 which is provided with a blood conduit 203 (which also serves to quantitatively receive the blood to be spotted) and an excess blood receiver 207.
  • a needle 205 is suspended by a coil spring 206 under engagement between the upper end 203a of the blood conduit 203 and the upper end 205a of the needle 205.
  • the puncturing tip 200 When the puncturing tip 200 is fitted to the main body 100, the lower end of the needle 205 is encased in the blood conduit 203. However, the needle 205 is pushed down (or protruded) from the lower end of the blood conduit 203 by descending action of the sliding means. Under the condition, the needle 205 is protruded by a length of 1 to 2 mm from the lower end of the blood conduit 203.
  • a space 114 having a diameter smaller than the diameter of that of the cylindrical portion is formed in the tapered cylinder portion 112.
  • the lower end of the tapered cylinder portion 112 is composed of a further smaller hole 115 and a bottom portion 116.
  • the outer surface of the tapered cylinder portion 112 is so processed as to be airtightly and exchangeably inserted into the upper end 202 of the puncturing tip 200.
  • the puncturing tip 200 is attached to the tapered cylinder portion 112 by friction. However, the puncturing tip can be screwed into the cylinder 110. Otherwise, other connecting means can be employed for keeping the cylinder and the puncturing tip from separation.
  • the piston 120 has a bottom 121 at the upper end, and the bottom 121 has a hole 122.
  • the piston 120 has a wall whose lower end 123 is shaped in the form of wedge.
  • a sealing means 124 is provided so as to seal the space between the inner surface of the cylinder 110 and the outer surface of the piston 120.
  • the sliding means 130 is composed of a cylindrical body 131, a spring supporting means 132, and a pushing means 133.
  • the sliding means 130 has a through-hole 134 which allows passage of air therethrough.
  • a portion 135 of the upper part of the cylindrical body 131 is cut off.
  • an indented portion 136 is formed.
  • the cylinder 110 has a protruded portion 117 on the inner surface of its wall in the portion above the cut-off portion 135 of the sliding means 130.
  • the lower end 133a of the pushing means 133 is located on the same level as that of the lower end of the tapered cylinder portion 112. Further, on the outer surface of the cylindrical body 131, a vertically extended groove 137 is formed. The groove 137 is engaged with a projecting portion 118 of the cylinder 110 so that the sliding means 130 can do up-and-down movement only.
  • a spring 141 is provided between the upper bottom 121 of the piston 120 and the top of the spring supporting means 132. Further, between the lower end of the cylindrical body 131 and the bottom portion 116 of the tapered cylinder portion 112, a spring 142 is provided. The sliding means 130 is pushed up by the spring 132 to keep the sliding means 130 under such condition that the upper end of the cylindrical body 131 is positioned in contact with the lower surface of the protruded portion 117.
  • Each of the cylinder, piston and sliding means can be preferably made of hard plastic material such as polystyrene, high density polyethylene, polypropylene, poly(vinyl chloride), polyacrylate resin or polycarbonate.
  • the sealing means can be in the form of a ring and can be made of rubber or soft plastic material such as soft poly(vinyl chloride) or low density polyethylene.
  • Each of the springs 141, 142 preferably is a coil spring.
  • the puncturing tip is preferably made of plastic material in one unit (except for the needle).
  • the plastic material preferably is transparent or semi-transparent so as to be easily check the blood received in the puncturing tip.
  • the plastic material can be hydrophilic or hydrophobic.
  • the puncturing tip made of hydrophilic plastic material is favorably employed because the blood can enter easily and smoothly into the blood conduit.
  • the hydrophilic plastic material include polyamide and ethylene-carboxylate copolymer, both of which are inherently hydrophilic.
  • hydrophobic plastic material which is made hydrophilic by compounding a hydrophilic plasticizer such as glycerol, ethylene glycol, polyethylene glycol, or glycerol fatty acid ester (e.g., glycerol laurate or glycerol stearate) also can be employed.
  • a hydrophilic plasticizer such as glycerol, ethylene glycol, polyethylene glycol, or glycerol fatty acid ester (e.g., glycerol laurate or glycerol stearate) also can be employed.
  • the puncturing tip is once made of hydrophobic plastic material and coated with a hydrophilic material at the inner surface of the blood conduit.
  • hydrophilic material include surface active agents (particularly, nonionic surfactants), hydrophilic polymer, and water-soluble organic compounds (e.g., glycerol ester, ethylene glycol, amino acid, and sugar).
  • the spring 206 can be any form of spring means.
  • a coil spring or leaf spring is preferred.
  • FIGS. 2 to 5 The procedures for collecting the blood by the use of the blood collecting and spotting means 1 of FIG. 1 according to the invention are described below by referring to FIGS. 2 to 5 in the drawings.
  • the pushing means 133 protruding from the tapered cylinder portion 112 of the main body at its lower end 133a is pushed up by a finger so that the cut-off upper end of the cylindrical body 131 of the sliding means 130 can be disengaged with the protruded portion 117 and can move upward to engage the indented portion 136 with the protruded portion 117, as is illustrated in FIG. 2.
  • the puncturing tip 200 is connected to the cylinder 110 by inserting the tapered cylinder portion 112 into the opened upper portion 202 airtightly.
  • FIG. 2 shows the condition in that the puncturing tip 200 is connected airtightly to the cylinder 110.
  • the numbers given in FIG. 2 indicate the same elements and portions as indicated in FIG. 1.
  • the lower end of the blood conduit 203 of the puncturing tip 200 is applied to a skin (S) of a human body, and the piston 120 is pushed down by pressing the upper end of the piston 120 by a finger (preferably, without closing the hole 122; other fingers are placed between the pair of flanges 113, 113').
  • the sliding means 130 is not moved because of the engagement with the protruded portion 117, and the spring 141 is contracted.
  • the wedge end 123 is inserted between the inner surface of the cylinder 110 and the cut-off upper end of the sliding means 130 to remove the engagement.
  • the sliding means 130 is instantly pushed down by the expanding action of the contracted spring 141.
  • the pushing means 133 quickly protrudes from the tapered cylinder portion 112.
  • the lower end of the pushing means 133 then pushes the upper end 205a of the needle 205 down, and the needle 205 protrudes slightly from the lower end of the puncturing tip 200 to enter into the skin.
  • the springs 142, 206 are contracted.
  • the pushing means 133 is ascended by action of the contracted spring 142 to the position where the cut-off portion 135 of the sliding means is brought into contact with the protruded portion 117 of the cylinder.
  • the spring 141 is then contracted.
  • the needle 205 is also ascended by action of the contacted spring 206, for instance, 5 to 30 seconds after the insertion into the skin.
  • the blood oozes through the hole formed by the insertion of the needle.
  • the pressure of the finger applied to the top of the piston 120 is slowly reduced, at this time, with closing the hole 122.
  • the piston 120 is slowly ascended by action of the contracted spring 141.
  • the pressure inside the cylinder 110 and puncturing tip 200 is reduced.
  • the blood is introduced into the blood conduit 203.
  • An excessive blood is received into the receiver 204. This condition is illustrated in FIG. 4.
  • the hole 122 of the piston is opened so that the pressure inside the cylinder 110 and puncturing tip 200 is returned to an atmospheric pressure.
  • the blood collecting and spotting means is removed from the skin. By the action of surface tension, the blood in the blood conduit 203 is kept without flowing down.
  • the blood collecting and spotting means is then moved onto an analytical means, and the piston 120 is pushed down with closing the hole 122 by the finger to push the blood out of the blood conduit 203.
  • the blood in the receiver 204 is not pushed out by this procedure.
  • FIG. 5 shows this spotting procedure. If the analytical means is made of blood absorbable material such as paper sheet, cloth, or porous sheet, the blood in the blood conduit automatically flows out when the lower end of the blood conduit is brought into contact with the analytical means, without applying the pressure on the piston.
  • the volume of blood to be applied to the analytical means is automatically made equivalent to the inner volume of the blood conduit (after reduction of the volume of the needle).
  • the volume of blood is kept at almost the same level in every blood collecting and spotting procedure, so long as the puncturing tip of the same size is employed in every procedure.
  • the needle and the blood conduit can be treated with an anticoagulant such as heparin or EDTA prior to initiating the blood collecting and spotting procedure, so that coagulation of the collected blood can be prevented.
  • an anticoagulant such as heparin or EDTA
  • the puncturing tip 200 is removed and disposed. Since the main body 100 having the cylinder, piston and pushing means is completely kept from the blood in the procedure, the main body 100 can be repeatedly employed by attaching a fresh puncturing tip.
  • the volume inside of the blood conduit 203 is optionally adjusted, generally, to a volume less than 100 ⁇ L, preferably in the range of 5 to 50 ⁇ L, more preferably in the range of 5 to 30 ⁇ L.
  • the hole 122 of the piston 120 can be omitted.
  • the volume of the blood introduced into the blood conduit can be adjusted by controlling the movement of the piston.
  • FIGS. 6 to 8 one of other structures of the puncturing tip according to the invention is described below, by referring to FIGS. 6 to 8 in the attached drawings.
  • a puncturing tip 300 comprises a housing 310 and a needle portion 320.
  • the housing 310 is has a cylindrical body 311 whose upper end portion 312 is formed to be airtightly and exchangeably attached to the tapered cylinder portion 112 of the cylinder 110 and whose lower end has a blood conduit 313, a bottom plate 314, and an excessive blood receiver 315.
  • the cylindrical body 311 further has a shelf 316 on its inner surface to fix thereon a needle supporting means 322 in the form of a disk (see FIG. 7).
  • the needle portion 320 comprises a needle 321 and a needle supporting means 322.
  • the needle supporting means 322 comprises an outer ring 323 and an inner ring 324 which are connected via a flexible connecting portion 325 with each other.
  • a cylindrical needle holder 326 is connected with the inner ring 324 with a flexible connecting portion 327.
  • the combination of the flexible connecting portions 325, 327 functions as leaf spring to ensure the up-and-down movement of the needle 321.
  • the housing 310 is preferably formed in one unit, using hard plastic material.
  • the needle supporting means 322 also is preferably formed in one unit which includes the outer ring 323, inner ring 324, connecting portions 325, 327, and cylindrical needle holder 326.
  • the united needle supporting means is preferably made of polyethylene, polypropylene, acrylate polymer, or other plastic material.
  • the needle 321 can be made of metal or plastic material.
  • the plastic needle can be formed in one unit with the needle supporting means 322, for instance, by injection molding.
  • the pushing means 133 is pushed into the cylinder 110, and the puncturing tip 300 is attached airtightly to the tapered cylinder portion 112.
  • the piston is initially pushed down in the same manner as described hereinbefore. Then, the needle 321 is quickly pushed down to insert into a human body through a skin (S).
  • the needle supporting means 322, particularly, the combination of the flexible connecting portions 325, 327 functions as leaf spring in the same manner as the coil spring 206. Accordingly, the same procedures as those for the blood collecting and spotting means of FIGS. 1 to 5 can be done using the blood collecting and spotting means which is formed of the main body 100 and the puncturing tip 300 to collect the blood and spot a predetermined volume of the blood onto an analytical means with simple operations.

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  • Molecular Biology (AREA)
  • Surgery (AREA)
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  • Engineering & Computer Science (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Pain & Pain Management (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Abstract

A means for collecting and spotting a small amount of blood which comprises a cylinder, a piston, and a puncturing tip, wherein: the piston is inserted airtightly into one end of the cylinder; the puncturing tip is airtightly and exchangeably fitted onto another end of the cylinder; the puncturing tip comprises a blood conduit and a needle suspended by a spring within the blood conduit; the blood conduit has a volume which is equal to a volume of blood to be spotted to analytical means; and the needle is arranged to be pushed out from the puncturing tip by descent of the piston and then return back by ascent of the piston.

Description

FIELD OF THE INVENTION
This invention relates to means for collecting and spotting a small amount of blood.
BACKGROUND OF THE INVENTION
In the medical and health examinations, the blood is generally tested. For performing the blood test, a small but certain amount of blood is required. Generally, the blood is taken by an expert such as a medical doctor or a nurse through vein. In some cases, several drops of blood are taken by slightly injuring a finger tip or an earlobe.
As means for testing the blood in clinical tests, there are known multi-layered analytical elements which contain chemical reagents, biochemical reagents, or immunological reagents. In the clinical tests using the multi-layered analytical elements (possibly, in the form of an analytical slide), a small but predetermined amount of the blood should be spotted onto the analytical element for causing a color development in the element. The developed color is then measured at a predetermined wavelength to quantitatively determine the analyte in the blood.
The procedure for collecting the blood is also performed by a patient per se, for checking blood sugar level or cholesterol level by himself. Particularly, in the case of diabetic, the blood sugar level ought to be checked frequently (for instance, several times a day), though each check procedure requires only a small amount of the blood. Generally, the blood is taken at a finger tip, because a great number of blood vessels are gathered at the finger tip. However, the blood collection at the finger tip sometimes causes acute pain, because a great number of nerves are also gathered at the finger tip. The blood collection at the finger tip is also sometimes troublesome, because the finger tip is frequently used for daily works. For these reasons, the blood collection at other portions is sometimes required.
Therefore, it is required to provide a blood collecting and spotting means which is employable for taking a small amount of blood and spotting a predetermined amount of blood onto an analytical means with little pain and no complicated procedures.
Japanese Patent Provisional Publications No. 62-38140, No. H-1-185245, and No. H-5-95938 describe means for collecting a small amount of blood from a human body with simple operation. These means, however, are not designed for spotting a predetermined amount of the collected blood sample onto an analytical means.
SUMMARY OF THE INVENTION
The present invention has an object to provide a blood collecting and spotting means which is employable for taking a small amount of blood and spotting a predetermined amount of blood onto an analytical means with little pain and no complicated procedures.
The invention also has an object to provide a blood collecting and spotting means which is repeatedly employable with replacement of a needle tip.
The present invention resides in a means for collecting and spotting a small amount of blood which comprises a cylinder, a piston, and a puncturing tip, wherein:
the piston is inserted airtightly into the upper end of the cylinder;
the puncturing tip is airtightly and exchangeably fitted onto the lower end of the cylinder;
the puncturing tip comprises a blood conduit and a needle suspended by a spring within the blood conduit;
the blood conduit has a volume which is equal to a volume of blood to be spotted to analytical means; and
the needle is arranged to be pushed out from the puncturing tip by descent of the piston and then return back by ascent of the piston.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 illustrates an example of the means for collecting and spotting a small amount of blood according to the invention, by separating the cylinder portion and puncturing tip.
FIG. 2 illustrates the blood collecting and spotting means of FIG. 1 under the condition that the sliding means is pushed in and fixed and the puncturing tip is fitted to the cylinder.
FIG. 3 illustrates the blood collecting and spotting means of FIG. 2 under the condition that the piston is pushed down, the sliding means is slide down and then the needle is pushed down to be inserted into a part of human body through skin.
FIG. 4 illustrates the blood collecting and spotting means of FIG. 3 under the condition that the piston is returned to the original position, the sliding means is slide up, the needle is pushed up by the action of the spring, and then blood is taken out to fill up the blood conduit. An excess of the taken blood is received in a blood receiver of the puncturing tip.
FIG. 5 illustrates the blood collecting and spotting means of FIG. 4 under the condition that the piston is again pushed down, the sliding means is slide down, and then a blood is pushed down to be spotted onto an analytical means (not shown).
FIG. 6 illustrates another example of the puncturing tip to be attached to the blood collecting and spotting means of the invention.
FIG. 7 illustrates a top view of the spring means for suspending the needle shown in FIG. 6.
FIG. 8 illustrates a lower portion of the blood collecting and spotting means of FIG. 6 under the condition that the needle is inserted into a part of human body.
DETAILED DESCRIPTION OF THE INVENTION
The present invention is described in more detail by referring to the attached drawings.
In FIG. 1, an example of the blood collecting and spotting means 1 comprises a main body 100 and a puncturing tip 200.
The main body 100 is composed of a cylinder 110, a piston 120, and a sliding means 130. The cylinder 110 has a tapered cylinder portion 112 at the lower end of the cylindrical portion 111 and two flanges 113, 113' at the upper end. The piston 120 is inserted into the cylinder 110 under such condition that the piston 120 is able to descend and ascend within the cylinder 110.
The puncturing tip 200 has a cylindrical body 201 whose opened upper end 202 is so tapered that the tip is airtightly and exchangeably fitted to the tapered cylinder portion 112 of the cylinder 110. The puncturing tip 200 further has a lower portion 204 which is provided with a blood conduit 203 (which also serves to quantitatively receive the blood to be spotted) and an excess blood receiver 207. Within the blood conduit, a needle 205 is suspended by a coil spring 206 under engagement between the upper end 203a of the blood conduit 203 and the upper end 205a of the needle 205.
When the puncturing tip 200 is fitted to the main body 100, the lower end of the needle 205 is encased in the blood conduit 203. However, the needle 205 is pushed down (or protruded) from the lower end of the blood conduit 203 by descending action of the sliding means. Under the condition, the needle 205 is protruded by a length of 1 to 2 mm from the lower end of the blood conduit 203.
In the tapered cylinder portion 112, a space 114 having a diameter smaller than the diameter of that of the cylindrical portion is formed. The lower end of the tapered cylinder portion 112 is composed of a further smaller hole 115 and a bottom portion 116. The outer surface of the tapered cylinder portion 112 is so processed as to be airtightly and exchangeably inserted into the upper end 202 of the puncturing tip 200. The puncturing tip 200 is attached to the tapered cylinder portion 112 by friction. However, the puncturing tip can be screwed into the cylinder 110. Otherwise, other connecting means can be employed for keeping the cylinder and the puncturing tip from separation.
The piston 120 has a bottom 121 at the upper end, and the bottom 121 has a hole 122. The piston 120 has a wall whose lower end 123 is shaped in the form of wedge. On the outer surface of the piston 120, a sealing means 124 is provided so as to seal the space between the inner surface of the cylinder 110 and the outer surface of the piston 120.
The sliding means 130 is composed of a cylindrical body 131, a spring supporting means 132, and a pushing means 133. The sliding means 130 has a through-hole 134 which allows passage of air therethrough. A portion 135 of the upper part of the cylindrical body 131 is cut off. Just under the cut-off portion 135, an indented portion 136 is formed. The cylinder 110 has a protruded portion 117 on the inner surface of its wall in the portion above the cut-off portion 135 of the sliding means 130. When the sliding means 130 is pushed up (details will be described hereinafter) to engage the indented portion 136 with the protruded portion 117, the lower end 133a of the pushing means 133 is located on the same level as that of the lower end of the tapered cylinder portion 112. Further, on the outer surface of the cylindrical body 131, a vertically extended groove 137 is formed. The groove 137 is engaged with a projecting portion 118 of the cylinder 110 so that the sliding means 130 can do up-and-down movement only.
Between the upper bottom 121 of the piston 120 and the top of the spring supporting means 132, a spring 141 is provided. Further, between the lower end of the cylindrical body 131 and the bottom portion 116 of the tapered cylinder portion 112, a spring 142 is provided. The sliding means 130 is pushed up by the spring 132 to keep the sliding means 130 under such condition that the upper end of the cylindrical body 131 is positioned in contact with the lower surface of the protruded portion 117.
Each of the cylinder, piston and sliding means can be preferably made of hard plastic material such as polystyrene, high density polyethylene, polypropylene, poly(vinyl chloride), polyacrylate resin or polycarbonate. The sealing means can be in the form of a ring and can be made of rubber or soft plastic material such as soft poly(vinyl chloride) or low density polyethylene. Each of the springs 141, 142 preferably is a coil spring.
The puncturing tip is preferably made of plastic material in one unit (except for the needle). The plastic material preferably is transparent or semi-transparent so as to be easily check the blood received in the puncturing tip. The plastic material can be hydrophilic or hydrophobic. However, the puncturing tip made of hydrophilic plastic material is favorably employed because the blood can enter easily and smoothly into the blood conduit. Examples of the hydrophilic plastic material include polyamide and ethylene-carboxylate copolymer, both of which are inherently hydrophilic. However, a hydrophobic plastic material which is made hydrophilic by compounding a hydrophilic plasticizer such as glycerol, ethylene glycol, polyethylene glycol, or glycerol fatty acid ester (e.g., glycerol laurate or glycerol stearate) also can be employed.
Otherwise, the puncturing tip is once made of hydrophobic plastic material and coated with a hydrophilic material at the inner surface of the blood conduit. Examples of the hydrophilic material include surface active agents (particularly, nonionic surfactants), hydrophilic polymer, and water-soluble organic compounds (e.g., glycerol ester, ethylene glycol, amino acid, and sugar).
The spring 206 can be any form of spring means. A coil spring or leaf spring is preferred.
The procedures for collecting the blood by the use of the blood collecting and spotting means 1 of FIG. 1 according to the invention are described below by referring to FIGS. 2 to 5 in the drawings.
First, the pushing means 133 protruding from the tapered cylinder portion 112 of the main body at its lower end 133a is pushed up by a finger so that the cut-off upper end of the cylindrical body 131 of the sliding means 130 can be disengaged with the protruded portion 117 and can move upward to engage the indented portion 136 with the protruded portion 117, as is illustrated in FIG. 2. Thereafter, the puncturing tip 200 is connected to the cylinder 110 by inserting the tapered cylinder portion 112 into the opened upper portion 202 airtightly. FIG. 2 shows the condition in that the puncturing tip 200 is connected airtightly to the cylinder 110. The numbers given in FIG. 2 indicate the same elements and portions as indicated in FIG. 1.
For collecting the blood, the lower end of the blood conduit 203 of the puncturing tip 200 is applied to a skin (S) of a human body, and the piston 120 is pushed down by pressing the upper end of the piston 120 by a finger (preferably, without closing the hole 122; other fingers are placed between the pair of flanges 113, 113'). Initially, the sliding means 130 is not moved because of the engagement with the protruded portion 117, and the spring 141 is contracted. When the piston 120 is further descended, the wedge end 123 is inserted between the inner surface of the cylinder 110 and the cut-off upper end of the sliding means 130 to remove the engagement. By the disengagement, the sliding means 130 is instantly pushed down by the expanding action of the contracted spring 141. Then, the pushing means 133 quickly protrudes from the tapered cylinder portion 112. The lower end of the pushing means 133 then pushes the upper end 205a of the needle 205 down, and the needle 205 protrudes slightly from the lower end of the puncturing tip 200 to enter into the skin. By this action, the springs 142, 206 are contracted.
After the needle 205 enters into the skin, the pushing means 133 is ascended by action of the contracted spring 142 to the position where the cut-off portion 135 of the sliding means is brought into contact with the protruded portion 117 of the cylinder. The spring 141 is then contracted. The needle 205 is also ascended by action of the contacted spring 206, for instance, 5 to 30 seconds after the insertion into the skin. In the course of the ascent of the needle 205, the blood oozes through the hole formed by the insertion of the needle. Then, the pressure of the finger applied to the top of the piston 120 is slowly reduced, at this time, with closing the hole 122. By the reduction of the pressure, the piston 120 is slowly ascended by action of the contracted spring 141. By the ascent of the piston 120, the pressure inside the cylinder 110 and puncturing tip 200 is reduced. As a result, the blood is introduced into the blood conduit 203. An excessive blood is received into the receiver 204. This condition is illustrated in FIG. 4.
Subsequently, the hole 122 of the piston is opened so that the pressure inside the cylinder 110 and puncturing tip 200 is returned to an atmospheric pressure. At the same time, the blood collecting and spotting means is removed from the skin. By the action of surface tension, the blood in the blood conduit 203 is kept without flowing down.
The blood collecting and spotting means is then moved onto an analytical means, and the piston 120 is pushed down with closing the hole 122 by the finger to push the blood out of the blood conduit 203. The blood in the receiver 204 is not pushed out by this procedure. FIG. 5 shows this spotting procedure. If the analytical means is made of blood absorbable material such as paper sheet, cloth, or porous sheet, the blood in the blood conduit automatically flows out when the lower end of the blood conduit is brought into contact with the analytical means, without applying the pressure on the piston.
Accordingly, the volume of blood to be applied to the analytical means is automatically made equivalent to the inner volume of the blood conduit (after reduction of the volume of the needle). The volume of blood is kept at almost the same level in every blood collecting and spotting procedure, so long as the puncturing tip of the same size is employed in every procedure.
The needle and the blood conduit can be treated with an anticoagulant such as heparin or EDTA prior to initiating the blood collecting and spotting procedure, so that coagulation of the collected blood can be prevented.
After the blood collecting and spotting procedure is complete, the puncturing tip 200 is removed and disposed. Since the main body 100 having the cylinder, piston and pushing means is completely kept from the blood in the procedure, the main body 100 can be repeatedly employed by attaching a fresh puncturing tip.
The volume inside of the blood conduit 203 is optionally adjusted, generally, to a volume less than 100 μL, preferably in the range of 5 to 50 μL, more preferably in the range of 5 to 30 μL.
The hole 122 of the piston 120 can be omitted. In this structure, the volume of the blood introduced into the blood conduit can be adjusted by controlling the movement of the piston.
Further, one of other structures of the puncturing tip according to the invention is described below, by referring to FIGS. 6 to 8 in the attached drawings.
In FIG. 6, a puncturing tip 300 comprises a housing 310 and a needle portion 320. The housing 310 is has a cylindrical body 311 whose upper end portion 312 is formed to be airtightly and exchangeably attached to the tapered cylinder portion 112 of the cylinder 110 and whose lower end has a blood conduit 313, a bottom plate 314, and an excessive blood receiver 315. The cylindrical body 311 further has a shelf 316 on its inner surface to fix thereon a needle supporting means 322 in the form of a disk (see FIG. 7).
The needle portion 320 comprises a needle 321 and a needle supporting means 322. The needle supporting means 322 comprises an outer ring 323 and an inner ring 324 which are connected via a flexible connecting portion 325 with each other. At the center of the needle supporting means 322, a cylindrical needle holder 326 is connected with the inner ring 324 with a flexible connecting portion 327. The combination of the flexible connecting portions 325, 327 functions as leaf spring to ensure the up-and-down movement of the needle 321.
The housing 310 is preferably formed in one unit, using hard plastic material. The needle supporting means 322 also is preferably formed in one unit which includes the outer ring 323, inner ring 324, connecting portions 325, 327, and cylindrical needle holder 326. The united needle supporting means is preferably made of polyethylene, polypropylene, acrylate polymer, or other plastic material. The needle 321 can be made of metal or plastic material. The plastic needle can be formed in one unit with the needle supporting means 322, for instance, by injection molding.
The procedures for collecting and spotting the blood using the puncturing tip 300 which is attached to the main body 100 are described below.
As is described before, initially the pushing means 133 is pushed into the cylinder 110, and the puncturing tip 300 is attached airtightly to the tapered cylinder portion 112.
In the blood collecting procedures, the piston is initially pushed down in the same manner as described hereinbefore. Then, the needle 321 is quickly pushed down to insert into a human body through a skin (S). In the puncturing tip 300, the needle supporting means 322, particularly, the combination of the flexible connecting portions 325, 327 functions as leaf spring in the same manner as the coil spring 206. Accordingly, the same procedures as those for the blood collecting and spotting means of FIGS. 1 to 5 can be done using the blood collecting and spotting means which is formed of the main body 100 and the puncturing tip 300 to collect the blood and spot a predetermined volume of the blood onto an analytical means with simple operations.

Claims (3)

We claim:
1. An apparatus for collecting and delivering a small amount of blood which comprises a cylinder, a piston, and a puncturing tip, wherein
the piston is inserted airtightly into the upper end of the cylinder;
the puncturing tip is airtightly and exchangeably fitted onto the lower end of the cylinder;
the puncturing tip comprises a blood conduit and a needle suspended by a spring within the blood conduit;
the blood conduit has a volume which is equal to a volume of blood to be delivered; and
the needle is arranged to be pushed out from the puncturing tip by descent of the piston and then returned back by ascent of the piston,
wherein
the cylinder contains in its lower end, a sliding means having a through-hole therein, the top the sliding means being connected with the piston via a spring, the lower end of the sliding means protruding from the lower end of the cylinder, the lower end of the sliding means being able to be so pushed into the cylinder that the sliding means is fixed in a predetermined position under engagement with the inner surface of the cylinder and being able to be pushed down rapidly by breakage of the engagement which is caused by the descent of the piston.
2. The means as defined in claim 1, wherein the puncturing tip has a receiver for receiving an excess amount of the collected blood.
3. The apparatus of claim 1, wherein the needle is suspended within the blood conduit by means of a leaf spring of plastic material.
US08/353,108 1993-12-09 1994-12-09 Means for collecting and spotting small amount of blood Expired - Fee Related US5569287A (en)

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JP34151093 1993-12-09
JP5-341510 1993-12-09
JP6-098130 1994-04-11
JP09813094A JP3393920B2 (en) 1993-12-09 1994-04-11 Wearing equipment for small-volume fixed-volume blood sampling points

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Cited By (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5741291A (en) * 1996-02-23 1998-04-21 Yoo; Tae Woo Acupuncture of the bleeding
US5871494A (en) * 1997-12-04 1999-02-16 Hewlett-Packard Company Reproducible lancing for sampling blood
US5984940A (en) * 1997-05-29 1999-11-16 Atrion Medical Products, Inc. Lancet device
US6022366A (en) * 1998-06-11 2000-02-08 Stat Medical Devices Inc. Lancet having adjustable penetration depth
WO2000040150A1 (en) * 1999-01-04 2000-07-13 Terumo Kabushiki Kaisha Assembly having lancet and means for collecting and detecting body fluid
US6283982B1 (en) 1999-10-19 2001-09-04 Facet Technologies, Inc. Lancing device and method of sample collection
US20020096317A1 (en) * 2001-01-23 2002-07-25 Colin Hargreaves Heat exchanger tube
US20020103499A1 (en) * 2001-01-22 2002-08-01 Perez Edward P. Lancet device having capillary action
US6530937B1 (en) 2000-01-28 2003-03-11 Stat Medical Devices, Inc. Adjustable tip for a lancet device and method
US20030144609A1 (en) * 2002-01-31 2003-07-31 Kennedy Gwenn E. Single use device for blood microsampling
US6613064B2 (en) * 2000-04-04 2003-09-02 P.Z. “Htl” S.A. Arrangement regulating depth of the puncture, used in the device for puncturing
US6616616B2 (en) * 2000-09-26 2003-09-09 Roche Diagnostics Corporation Lancet system
US20030225430A1 (en) * 1998-06-11 2003-12-04 Stat Medical Devices Inc. Lancet having adjustable penetration depth
US20040098008A1 (en) * 2002-05-31 2004-05-20 Taylor William C. Precisely guided lancet
US20040181249A1 (en) * 2003-03-10 2004-09-16 Pathway Medical Technologies, Inc. Bearing system to support a rotatable operating head in an intracorporeal device
US20040236362A1 (en) * 2003-05-20 2004-11-25 Stat Medical Devices, Inc. Adjustable lancet device and method
US20040243165A1 (en) * 2001-07-11 2004-12-02 Masufumi Koike Lancet and piercing device
US20040249406A1 (en) * 2003-03-20 2004-12-09 Griffin Carl E. Lancing device with decoupled lancet
US20040248312A1 (en) * 2003-06-06 2004-12-09 Bayer Healthcare, Llc Sensor with integrated lancet
US20040254599A1 (en) * 2003-03-25 2004-12-16 Lipoma Michael V. Method and apparatus for pre-lancing stimulation of puncture site
US20040260326A1 (en) * 2003-03-24 2004-12-23 Lipoma Michael V. Lancing device with floating lancet
US20050288699A1 (en) * 2004-06-29 2005-12-29 Stat Medical Devices, Inc. Adjustable disposable/single-use lancet device and method
WO2006030201A1 (en) 2004-09-13 2006-03-23 Microsample Ltd. Method and apparatus for sampling and analysis of fluids
US20060106411A1 (en) * 2004-11-16 2006-05-18 Stat Medical Devices Inc. Adjustable disposable/single-use blade lancet device and method
US7105006B2 (en) 2003-08-15 2006-09-12 Stat Medical Devices, Inc. Adjustable lancet device and method
US20070060937A1 (en) * 2005-08-30 2007-03-15 Liu Chen H Safety needle holder
WO2007104960A1 (en) 2006-03-13 2007-09-20 Microsample Ltd. Method and apparatus for piercing the skin and delivery or collection of liquids
US20070282362A1 (en) * 2004-03-30 2007-12-06 Bjorn Berg Sampler Device
US20090299224A1 (en) * 2005-06-08 2009-12-03 Jae Chern Yoo Lancet device and method for sampling and injecting blood using the lancet device
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7666149B2 (en) 1997-12-04 2010-02-23 Peliken Technologies, Inc. Cassette of lancet cartridges for sampling blood
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7682318B2 (en) 2001-06-12 2010-03-23 Pelikan Technologies, Inc. Blood sampling apparatus and method
US7699791B2 (en) 2001-06-12 2010-04-20 Pelikan Technologies, Inc. Method and apparatus for improving success rate of blood yield from a fingerstick
US7704265B2 (en) 2005-11-03 2010-04-27 Stat Medical Devices, Inc. Disposable/single-use blade lancet device and method
US7708701B2 (en) 2002-04-19 2010-05-04 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7731729B2 (en) 2002-04-19 2010-06-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7749174B2 (en) 2001-06-12 2010-07-06 Pelikan Technologies, Inc. Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge
WO2010086380A1 (en) 2009-01-30 2010-08-05 Pronota N.V. Biomarker for diagnosis, prediction and/or prognosis of acute heart failure and uses thereof
US7780631B2 (en) 1998-03-30 2010-08-24 Pelikan Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
US7833171B2 (en) 2002-04-19 2010-11-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7850622B2 (en) 2001-06-12 2010-12-14 Pelikan Technologies, Inc. Tissue penetration device
US7862520B2 (en) 2002-04-19 2011-01-04 Pelikan Technologies, Inc. Body fluid sampling module with a continuous compression tissue interface surface
US7874994B2 (en) 2002-04-19 2011-01-25 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7892185B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901365B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7905898B2 (en) 2003-08-15 2011-03-15 Stat Medical Devices, Inc. Adjustable lancet device and method
USD634426S1 (en) 2010-04-08 2011-03-15 Facet Technologies, Llc Lancing device
US7909777B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7914465B2 (en) 2002-04-19 2011-03-29 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
WO2011048173A1 (en) 2009-10-21 2011-04-28 Pronota N.V. Mcam as a biomarker for fluid homeostasis
US20110160759A1 (en) * 2007-02-09 2011-06-30 Stat Medical Devices, Inc. Multi-lancet unit, method and lancet device using the multi-lancet unit, and method of assembling and/or making the multi-lancet unit
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7988645B2 (en) 2001-06-12 2011-08-02 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US8007446B2 (en) 2002-04-19 2011-08-30 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
WO2011128357A2 (en) 2010-04-13 2011-10-20 Pronota N.V. Biomarkers for hypertensive disorders of pregnancy
US8043318B2 (en) 2007-02-08 2011-10-25 Stat Medical Devices, Inc. Push-button lance device and method
US8066728B2 (en) 2004-11-30 2011-11-29 Stat Medical Devices, Inc. Disposable or single-use lancet device and method
US8079960B2 (en) 2002-04-19 2011-12-20 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US8197421B2 (en) 2002-04-19 2012-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8262614B2 (en) 2003-05-30 2012-09-11 Pelikan Technologies, Inc. Method and apparatus for fluid injection
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
US8337421B2 (en) 2001-06-12 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8353924B2 (en) 1999-11-02 2013-01-15 Stat Medical Devices, Inc. Single use lancet assembly
US8360994B2 (en) 2005-09-30 2013-01-29 Intuity Medical, Inc. Arrangement for body fluid sample extraction
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8435190B2 (en) 2002-04-19 2013-05-07 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8556829B2 (en) 2002-04-19 2013-10-15 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US8668656B2 (en) 2003-12-31 2014-03-11 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US8715309B2 (en) 2002-04-29 2014-05-06 Steven Schraga Lancet device
US8721671B2 (en) 2001-06-12 2014-05-13 Sanofi-Aventis Deutschland Gmbh Electric lancet actuator
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US8814896B2 (en) 1999-11-02 2014-08-26 Stat Medical Devices, Inc. Single use lancet assembly
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
US8919605B2 (en) 2009-11-30 2014-12-30 Intuity Medical, Inc. Calibration material delivery devices and methods
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8969097B2 (en) 2005-06-13 2015-03-03 Intuity Medical, Inc. Analyte detection devices and methods with hematocrit-volume correction and feedback control
US9095292B2 (en) 2003-03-24 2015-08-04 Intuity Medical, Inc. Analyte concentration detection devices and methods
US9144401B2 (en) 2003-06-11 2015-09-29 Sanofi-Aventis Deutschland Gmbh Low pain penetrating member
EP2924439A1 (en) 2010-03-26 2015-09-30 Mycartis N.V. Ltbp2 as a biomarker for predicting or prognosticating mortality
US9179867B2 (en) 2007-06-19 2015-11-10 Stat Medical Devices, Inc. Lancet device with depth adjustment and lancet removal system and method
US9204833B2 (en) 2012-03-27 2015-12-08 Phlebotics, Inc. Cartridge for automated blood sampling system
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US9282918B2 (en) 2005-01-28 2016-03-15 Stat Medical Devices, Inc. Multi-lancet unit, method and lancet device using the multi-lancet unit, and method of assembling and/or making the multi-lancet unit
US9307939B2 (en) 2007-03-30 2016-04-12 Stat Medical Devices, Inc. Lancet device with combined trigger and cocking mechanism
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US9386944B2 (en) 2008-04-11 2016-07-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte detecting device
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9636051B2 (en) 2008-06-06 2017-05-02 Intuity Medical, Inc. Detection meter and mode of operation
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US9782114B2 (en) 2011-08-03 2017-10-10 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9820684B2 (en) 2004-06-03 2017-11-21 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US9833183B2 (en) 2008-05-30 2017-12-05 Intuity Medical, Inc. Body fluid sampling device—sampling site interface
USD806246S1 (en) 2016-02-25 2017-12-26 Steven Schraga Lancet cover
US20180242895A1 (en) * 2015-05-25 2018-08-30 Coyote Bioscience Yixing Co., Ltd. Device and method for sample collection
US10070811B2 (en) 2014-06-26 2018-09-11 Stat Medical Devices, Inc. Lancing device with depth adjustment and lancet removal system and method
CN109647559A (en) * 2019-01-21 2019-04-19 上海陶术生物科技有限公司 A kind of full-automatic liquid relief station with anti-drip structure
US10330667B2 (en) 2010-06-25 2019-06-25 Intuity Medical, Inc. Analyte monitoring methods and systems
US10383556B2 (en) 2008-06-06 2019-08-20 Intuity Medical, Inc. Medical diagnostic devices and methods
US10702199B2 (en) 2015-06-17 2020-07-07 Hitachi High-Tech Corporation Blood collecting device
US10729386B2 (en) 2013-06-21 2020-08-04 Intuity Medical, Inc. Analyte monitoring system with audible feedback
US10772550B2 (en) 2002-02-08 2020-09-15 Intuity Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US11395614B2 (en) 2012-01-25 2022-07-26 Tasso, Inc. Methods, systems, and devices relating to open microfluidic channels
US11510659B2 (en) * 2018-09-14 2022-11-29 Tasso, Inc. Bodily fluid collection devices and related methods
US11642057B2 (en) 2015-12-21 2023-05-09 Tasso, Inc. Devices, systems and methods for actuation and retraction in fluid collection
US11998334B2 (en) 2014-08-01 2024-06-04 Tasso, Inc. Devices, systems and methods for gravity-enhanced microfluidic collection, handling and transferring of fluids

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674236A (en) * 1996-04-30 1997-10-07 Medtronic, Inc. Lancet for capillary puncture blood samples
US7887494B2 (en) * 2005-09-30 2011-02-15 Intuity Medical, Inc. Fluid sample transport devices and methods
JP5002266B2 (en) * 2006-01-11 2012-08-15 キヤノン株式会社 Body fluid collection device
JP5028697B2 (en) * 2008-02-18 2012-09-19 富士フイルム株式会社 Suction syringe and endoscope suction syringe
JP5267399B2 (en) * 2009-02-03 2013-08-21 パナソニック株式会社 Sample collection device
CA3005826C (en) * 2013-04-15 2021-11-23 Becton, Dickinson And Company Biological fluid collection device and biological fluid separation and testing system
JP6339663B2 (en) * 2013-04-15 2018-06-06 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ Biological fluid collection device and biological fluid collection inspection system
KR20210066481A (en) * 2019-11-28 2021-06-07 가톨릭관동대학교산학협력단 Disposable blood collection device
CN112547144B (en) * 2020-11-13 2022-04-26 青岛大学附属医院 Capillary tube for storing and adding sample stabilizer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4553541A (en) * 1981-03-23 1985-11-19 Becton, Dickinson And Co. Automatic retractable lancet assembly
US5026388A (en) * 1989-09-26 1991-06-25 Ingalz Thomas J Single-use skin puncture device
US5318584A (en) * 1992-04-13 1994-06-07 Boehringer Mannheim Gmbh Blood lancet device for withdrawing blood for diagnostic purposes
US5356420A (en) * 1992-08-03 1994-10-18 Przedsiebiorstwo Zagraniczne Htl Device for puncturing

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4553541A (en) * 1981-03-23 1985-11-19 Becton, Dickinson And Co. Automatic retractable lancet assembly
US5026388A (en) * 1989-09-26 1991-06-25 Ingalz Thomas J Single-use skin puncture device
US5318584A (en) * 1992-04-13 1994-06-07 Boehringer Mannheim Gmbh Blood lancet device for withdrawing blood for diagnostic purposes
US5356420A (en) * 1992-08-03 1994-10-18 Przedsiebiorstwo Zagraniczne Htl Device for puncturing

Cited By (249)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5741291A (en) * 1996-02-23 1998-04-21 Yoo; Tae Woo Acupuncture of the bleeding
US5984940A (en) * 1997-05-29 1999-11-16 Atrion Medical Products, Inc. Lancet device
US6156050A (en) * 1997-05-29 2000-12-05 Atrion Medical Products, Inc. Lancet device
US5871494A (en) * 1997-12-04 1999-02-16 Hewlett-Packard Company Reproducible lancing for sampling blood
US7666149B2 (en) 1997-12-04 2010-02-23 Peliken Technologies, Inc. Cassette of lancet cartridges for sampling blood
US8439872B2 (en) 1998-03-30 2013-05-14 Sanofi-Aventis Deutschland Gmbh Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US7780631B2 (en) 1998-03-30 2010-08-24 Pelikan Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US7947057B2 (en) 1998-06-11 2011-05-24 Stat Medical Devices, Inc. Lancet having adjustable penetration depth
US8834503B2 (en) 1998-06-11 2014-09-16 Stat Medical Devices, Inc. Lancet having adjustable penetration depth
US7311718B2 (en) 1998-06-11 2007-12-25 Stat Medical Devices Inc. Lancet having adjustable penetration depth
US20080045992A1 (en) * 1998-06-11 2008-02-21 Stat Medical Devices, Inc., Of North Miami, Fl Lancet having adjustable penetration depth
US6156051A (en) * 1998-06-11 2000-12-05 Stat Medical Devices Inc. Lancet having adjustable penetration depth
US6022366A (en) * 1998-06-11 2000-02-08 Stat Medical Devices Inc. Lancet having adjustable penetration depth
US7175641B1 (en) 1998-06-11 2007-02-13 Stat Medical Devices, Inc. Lancet having adjustable penetration depth
US20030225430A1 (en) * 1998-06-11 2003-12-04 Stat Medical Devices Inc. Lancet having adjustable penetration depth
WO2000040150A1 (en) * 1999-01-04 2000-07-13 Terumo Kabushiki Kaisha Assembly having lancet and means for collecting and detecting body fluid
US6283982B1 (en) 1999-10-19 2001-09-04 Facet Technologies, Inc. Lancing device and method of sample collection
US6749618B2 (en) 1999-10-19 2004-06-15 Therasense, Inc. Lancing device and method of sample collection
US20040225311A1 (en) * 1999-10-19 2004-11-11 Therasense, Inc. Lancing device and method of sample collection
US8366729B2 (en) 1999-10-19 2013-02-05 Abbott Diabetes Care Inc. Lancing device and method of sample collection
US20080021493A1 (en) * 1999-10-19 2008-01-24 Therasense, Inc. Lancing Device and Method of Sample Collection
US8353924B2 (en) 1999-11-02 2013-01-15 Stat Medical Devices, Inc. Single use lancet assembly
US8814896B2 (en) 1999-11-02 2014-08-26 Stat Medical Devices, Inc. Single use lancet assembly
US20030088261A1 (en) * 2000-01-28 2003-05-08 Stat Medical Device Inc. Adjustable tip for a lancet device and method
US6530937B1 (en) 2000-01-28 2003-03-11 Stat Medical Devices, Inc. Adjustable tip for a lancet device and method
US8709032B2 (en) 2000-01-28 2014-04-29 Stat Medical Devices, Inc. Adjustable tip for a lancet device and method
US6613064B2 (en) * 2000-04-04 2003-09-02 P.Z. “Htl” S.A. Arrangement regulating depth of the puncture, used in the device for puncturing
US6616616B2 (en) * 2000-09-26 2003-09-09 Roche Diagnostics Corporation Lancet system
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US7803123B2 (en) 2001-01-22 2010-09-28 Roche Diagnostics Operations, Inc. Lancet device having capillary action
US6866675B2 (en) * 2001-01-22 2005-03-15 Roche Diagnostics Operations, Inc. Lancet device having capillary action
US8257276B2 (en) 2001-01-22 2012-09-04 Roche Diagnostics Operations, Inc. Lancet device having capillary action
US20020103499A1 (en) * 2001-01-22 2002-08-01 Perez Edward P. Lancet device having capillary action
US20020096317A1 (en) * 2001-01-23 2002-07-25 Colin Hargreaves Heat exchanger tube
US8679033B2 (en) 2001-06-12 2014-03-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7682318B2 (en) 2001-06-12 2010-03-23 Pelikan Technologies, Inc. Blood sampling apparatus and method
US8641643B2 (en) 2001-06-12 2014-02-04 Sanofi-Aventis Deutschland Gmbh Sampling module device and method
US7909775B2 (en) 2001-06-12 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US8721671B2 (en) 2001-06-12 2014-05-13 Sanofi-Aventis Deutschland Gmbh Electric lancet actuator
US8382683B2 (en) 2001-06-12 2013-02-26 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8845550B2 (en) 2001-06-12 2014-09-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7850622B2 (en) 2001-06-12 2010-12-14 Pelikan Technologies, Inc. Tissue penetration device
US7981055B2 (en) 2001-06-12 2011-07-19 Pelikan Technologies, Inc. Tissue penetration device
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7988645B2 (en) 2001-06-12 2011-08-02 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US8360991B2 (en) 2001-06-12 2013-01-29 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9694144B2 (en) 2001-06-12 2017-07-04 Sanofi-Aventis Deutschland Gmbh Sampling module device and method
US8337421B2 (en) 2001-06-12 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8282577B2 (en) 2001-06-12 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US9937298B2 (en) 2001-06-12 2018-04-10 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9802007B2 (en) 2001-06-12 2017-10-31 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US8622930B2 (en) 2001-06-12 2014-01-07 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7699791B2 (en) 2001-06-12 2010-04-20 Pelikan Technologies, Inc. Method and apparatus for improving success rate of blood yield from a fingerstick
US8216154B2 (en) 2001-06-12 2012-07-10 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8211037B2 (en) 2001-06-12 2012-07-03 Pelikan Technologies, Inc. Tissue penetration device
US8206319B2 (en) 2001-06-12 2012-06-26 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8206317B2 (en) 2001-06-12 2012-06-26 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8123700B2 (en) 2001-06-12 2012-02-28 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US8016774B2 (en) 2001-06-12 2011-09-13 Pelikan Technologies, Inc. Tissue penetration device
US7749174B2 (en) 2001-06-12 2010-07-06 Pelikan Technologies, Inc. Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge
US8016847B2 (en) * 2001-07-11 2011-09-13 Arkray, Inc. Lancet and lancing apparatus
US20040243165A1 (en) * 2001-07-11 2004-12-02 Masufumi Koike Lancet and piercing device
US9560993B2 (en) 2001-11-21 2017-02-07 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US7357808B2 (en) 2002-01-31 2008-04-15 Facet Technologies, Llc Single use device for blood microsampling
US20030144609A1 (en) * 2002-01-31 2003-07-31 Kennedy Gwenn E. Single use device for blood microsampling
US20080065133A1 (en) * 2002-01-31 2008-03-13 Kennedy Gwenn E Lancing device with reuse prevention mechanism
US10772550B2 (en) 2002-02-08 2020-09-15 Intuity Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9186468B2 (en) 2002-04-19 2015-11-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7875047B2 (en) 2002-04-19 2011-01-25 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7892185B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901365B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909777B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7862520B2 (en) 2002-04-19 2011-01-04 Pelikan Technologies, Inc. Body fluid sampling module with a continuous compression tissue interface surface
US7914465B2 (en) 2002-04-19 2011-03-29 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9907502B2 (en) 2002-04-19 2018-03-06 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9839386B2 (en) 2002-04-19 2017-12-12 Sanofi-Aventis Deustschland Gmbh Body fluid sampling device with capacitive sensor
US7938787B2 (en) 2002-04-19 2011-05-10 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7833171B2 (en) 2002-04-19 2010-11-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7988644B2 (en) 2002-04-19 2011-08-02 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US9724021B2 (en) 2002-04-19 2017-08-08 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8007446B2 (en) 2002-04-19 2011-08-30 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8636673B2 (en) 2002-04-19 2014-01-28 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8562545B2 (en) 2002-04-19 2013-10-22 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7731729B2 (en) 2002-04-19 2010-06-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9498160B2 (en) 2002-04-19 2016-11-22 Sanofi-Aventis Deutschland Gmbh Method for penetrating tissue
US8556829B2 (en) 2002-04-19 2013-10-15 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8062231B2 (en) 2002-04-19 2011-11-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9339612B2 (en) 2002-04-19 2016-05-17 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8079960B2 (en) 2002-04-19 2011-12-20 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US8496601B2 (en) 2002-04-19 2013-07-30 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US8157748B2 (en) 2002-04-19 2012-04-17 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US8197421B2 (en) 2002-04-19 2012-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8197423B2 (en) 2002-04-19 2012-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8202231B2 (en) 2002-04-19 2012-06-19 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US7708701B2 (en) 2002-04-19 2010-05-04 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device
US8690796B2 (en) 2002-04-19 2014-04-08 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8235915B2 (en) 2002-04-19 2012-08-07 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7874994B2 (en) 2002-04-19 2011-01-25 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8491500B2 (en) 2002-04-19 2013-07-23 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US8808201B2 (en) * 2002-04-19 2014-08-19 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US9089294B2 (en) 2002-04-19 2015-07-28 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US9089678B2 (en) 2002-04-19 2015-07-28 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9072842B2 (en) 2002-04-19 2015-07-07 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8435190B2 (en) 2002-04-19 2013-05-07 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8430828B2 (en) 2002-04-19 2013-04-30 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US8905945B2 (en) 2002-04-19 2014-12-09 Dominique M. Freeman Method and apparatus for penetrating tissue
US8414503B2 (en) 2002-04-19 2013-04-09 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US8403864B2 (en) 2002-04-19 2013-03-26 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8388551B2 (en) 2002-04-19 2013-03-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus for multi-use body fluid sampling device with sterility barrier release
US8366637B2 (en) 2002-04-19 2013-02-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US8845549B2 (en) 2002-04-19 2014-09-30 Sanofi-Aventis Deutschland Gmbh Method for penetrating tissue
US8382682B2 (en) 2002-04-19 2013-02-26 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8715309B2 (en) 2002-04-29 2014-05-06 Steven Schraga Lancet device
US7322996B2 (en) 2002-05-31 2008-01-29 Facet Technologies, Llc Precisely guided lancet
US20040098008A1 (en) * 2002-05-31 2004-05-20 Taylor William C. Precisely guided lancet
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US9034639B2 (en) 2002-12-30 2015-05-19 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US20040181249A1 (en) * 2003-03-10 2004-09-16 Pathway Medical Technologies, Inc. Bearing system to support a rotatable operating head in an intracorporeal device
US7288102B2 (en) * 2003-03-20 2007-10-30 Facet Technologies, Llc Lancing device with decoupled lancet
US20040249406A1 (en) * 2003-03-20 2004-12-09 Griffin Carl E. Lancing device with decoupled lancet
US7494498B2 (en) 2003-03-24 2009-02-24 Facet Technologies, Llc Lancing device with floating lancet
US20040260326A1 (en) * 2003-03-24 2004-12-23 Lipoma Michael V. Lancing device with floating lancet
US9095292B2 (en) 2003-03-24 2015-08-04 Intuity Medical, Inc. Analyte concentration detection devices and methods
US8142466B2 (en) 2003-03-24 2012-03-27 Facet Technologies, Llc Lancing device with floating lancet
US20090105741A1 (en) * 2003-03-24 2009-04-23 Facet Technologies, Llc Lancing device with floating lancet
US20040254599A1 (en) * 2003-03-25 2004-12-16 Lipoma Michael V. Method and apparatus for pre-lancing stimulation of puncture site
US20040236362A1 (en) * 2003-05-20 2004-11-25 Stat Medical Devices, Inc. Adjustable lancet device and method
US7621931B2 (en) 2003-05-20 2009-11-24 Stat Medical Devices, Inc. Adjustable lancet device and method
US8262614B2 (en) 2003-05-30 2012-09-11 Pelikan Technologies, Inc. Method and apparatus for fluid injection
US8251921B2 (en) 2003-06-06 2012-08-28 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US20040248312A1 (en) * 2003-06-06 2004-12-09 Bayer Healthcare, Llc Sensor with integrated lancet
US9144401B2 (en) 2003-06-11 2015-09-29 Sanofi-Aventis Deutschland Gmbh Low pain penetrating member
US10034628B2 (en) 2003-06-11 2018-07-31 Sanofi-Aventis Deutschland Gmbh Low pain penetrating member
US7905898B2 (en) 2003-08-15 2011-03-15 Stat Medical Devices, Inc. Adjustable lancet device and method
US8888804B2 (en) 2003-08-15 2014-11-18 Stat Medical Devices, Inc. Adjustable lancet device and method
US7105006B2 (en) 2003-08-15 2006-09-12 Stat Medical Devices, Inc. Adjustable lancet device and method
US8945910B2 (en) 2003-09-29 2015-02-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US9561000B2 (en) 2003-12-31 2017-02-07 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
US8296918B2 (en) 2003-12-31 2012-10-30 Sanofi-Aventis Deutschland Gmbh Method of manufacturing a fluid sampling device with improved analyte detecting member configuration
US8668656B2 (en) 2003-12-31 2014-03-11 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
US20070282362A1 (en) * 2004-03-30 2007-12-06 Bjorn Berg Sampler Device
US9261476B2 (en) 2004-05-20 2016-02-16 Sanofi Sa Printable hydrogel for biosensors
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
US9820684B2 (en) 2004-06-03 2017-11-21 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US20050288699A1 (en) * 2004-06-29 2005-12-29 Stat Medical Devices, Inc. Adjustable disposable/single-use lancet device and method
US8257380B2 (en) 2004-06-29 2012-09-04 Stat Medical Devices, Inc. Adjustabable disposable/single-use lancet device and method
US8092394B2 (en) * 2004-09-13 2012-01-10 Microsample Ltd. Method and apparatus for sampling and analysis of fluids
WO2006030201A1 (en) 2004-09-13 2006-03-23 Microsample Ltd. Method and apparatus for sampling and analysis of fluids
US20070232956A1 (en) * 2004-09-13 2007-10-04 Microsample Ltd. Method and Apparatus for Sampling and Analysis of Fluids
US8105347B2 (en) 2004-11-16 2012-01-31 Stat Medical Devices, Inc. Adjustable disposable/single-use blade lancet device and method
US20060106411A1 (en) * 2004-11-16 2006-05-18 Stat Medical Devices Inc. Adjustable disposable/single-use blade lancet device and method
US8066728B2 (en) 2004-11-30 2011-11-29 Stat Medical Devices, Inc. Disposable or single-use lancet device and method
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
US9282918B2 (en) 2005-01-28 2016-03-15 Stat Medical Devices, Inc. Multi-lancet unit, method and lancet device using the multi-lancet unit, and method of assembling and/or making the multi-lancet unit
US9289161B2 (en) 2005-01-28 2016-03-22 Stat Medical Divices, Inc. Multi-lancet unit, method and lancet device using the multi-lancet unit, and method of assembling and/or making the multi-lancet unit
US20090299224A1 (en) * 2005-06-08 2009-12-03 Jae Chern Yoo Lancet device and method for sampling and injecting blood using the lancet device
CN101203177B (en) * 2005-06-08 2010-05-19 三星电子股份有限公司 Lancet device
US8969097B2 (en) 2005-06-13 2015-03-03 Intuity Medical, Inc. Analyte detection devices and methods with hematocrit-volume correction and feedback control
US9366636B2 (en) 2005-06-13 2016-06-14 Intuity Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
US10226208B2 (en) 2005-06-13 2019-03-12 Intuity Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
US11419532B2 (en) 2005-06-13 2022-08-23 Intuity Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
US20070060937A1 (en) * 2005-08-30 2007-03-15 Liu Chen H Safety needle holder
US10433780B2 (en) 2005-09-30 2019-10-08 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US8382681B2 (en) 2005-09-30 2013-02-26 Intuity Medical, Inc. Fully integrated wearable or handheld monitor
US11986298B2 (en) 2005-09-30 2024-05-21 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US10441205B2 (en) 2005-09-30 2019-10-15 Intuity Medical, Inc. Multi-site body fluid sampling and analysis cartridge
US10842427B2 (en) 2005-09-30 2020-11-24 Intuity Medical, Inc. Body fluid sampling arrangements
US8360993B2 (en) 2005-09-30 2013-01-29 Intuity Medical, Inc. Method for body fluid sample extraction
US9060723B2 (en) 2005-09-30 2015-06-23 Intuity Medical, Inc. Body fluid sampling arrangements
US8795201B2 (en) 2005-09-30 2014-08-05 Intuity Medical, Inc. Catalysts for body fluid sample extraction
US8360994B2 (en) 2005-09-30 2013-01-29 Intuity Medical, Inc. Arrangement for body fluid sample extraction
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US9380974B2 (en) 2005-09-30 2016-07-05 Intuity Medical, Inc. Multi-site body fluid sampling and analysis cartridge
US9839384B2 (en) 2005-09-30 2017-12-12 Intuity Medical, Inc. Body fluid sampling arrangements
US7704265B2 (en) 2005-11-03 2010-04-27 Stat Medical Devices, Inc. Disposable/single-use blade lancet device and method
US8454642B2 (en) 2005-11-03 2013-06-04 Stat Medical Devices, Inc. Disposable/single-use blade lancet device and method
US8876846B2 (en) 2005-11-03 2014-11-04 Stat Medical Devices, Inc. Disposable/single-use blade lancet device and method
US20090099478A1 (en) * 2006-03-13 2009-04-16 Microsample Ltd Method and apparatus for piercing the skin and delivery or collection of liquids
WO2007104960A1 (en) 2006-03-13 2007-09-20 Microsample Ltd. Method and apparatus for piercing the skin and delivery or collection of liquids
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US8043318B2 (en) 2007-02-08 2011-10-25 Stat Medical Devices, Inc. Push-button lance device and method
US9017356B2 (en) 2007-02-09 2015-04-28 Stat Medical Devices, Inc. Multi-lancet unit, method and lancet device using the multi-lancet unit, and method of assembling and/or making the multi-lancet unit
US20110160759A1 (en) * 2007-02-09 2011-06-30 Stat Medical Devices, Inc. Multi-lancet unit, method and lancet device using the multi-lancet unit, and method of assembling and/or making the multi-lancet unit
US9307939B2 (en) 2007-03-30 2016-04-12 Stat Medical Devices, Inc. Lancet device with combined trigger and cocking mechanism
US9179867B2 (en) 2007-06-19 2015-11-10 Stat Medical Devices, Inc. Lancet device with depth adjustment and lancet removal system and method
US10307095B2 (en) 2007-06-19 2019-06-04 Stat Medical Devices, Inc. Lancet device with depth adjustment and lancet removal system and method
US9386944B2 (en) 2008-04-11 2016-07-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte detecting device
US11045125B2 (en) 2008-05-30 2021-06-29 Intuity Medical, Inc. Body fluid sampling device-sampling site interface
US9833183B2 (en) 2008-05-30 2017-12-05 Intuity Medical, Inc. Body fluid sampling device—sampling site interface
US11399744B2 (en) 2008-06-06 2022-08-02 Intuity Medical, Inc. Detection meter and mode of operation
US9636051B2 (en) 2008-06-06 2017-05-02 Intuity Medical, Inc. Detection meter and mode of operation
US11986293B2 (en) 2008-06-06 2024-05-21 Intuity Medical, Inc. Medical diagnostic devices and methods
US11553860B2 (en) 2008-06-06 2023-01-17 Intuity Medical, Inc. Medical diagnostic devices and methods
US10383556B2 (en) 2008-06-06 2019-08-20 Intuity Medical, Inc. Medical diagnostic devices and methods
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
WO2010086380A1 (en) 2009-01-30 2010-08-05 Pronota N.V. Biomarker for diagnosis, prediction and/or prognosis of acute heart failure and uses thereof
WO2011048173A1 (en) 2009-10-21 2011-04-28 Pronota N.V. Mcam as a biomarker for fluid homeostasis
WO2011048168A1 (en) 2009-10-21 2011-04-28 Pronota N.V. Biomarker for diagnosis, prediction and/or prognosis of acute heart failure and uses thereof
US9897610B2 (en) 2009-11-30 2018-02-20 Intuity Medical, Inc. Calibration material delivery devices and methods
US8919605B2 (en) 2009-11-30 2014-12-30 Intuity Medical, Inc. Calibration material delivery devices and methods
US11933789B2 (en) 2009-11-30 2024-03-19 Intuity Medical, Inc. Calibration material delivery devices and methods
US11002743B2 (en) 2009-11-30 2021-05-11 Intuity Medical, Inc. Calibration material delivery devices and methods
EP2924439A1 (en) 2010-03-26 2015-09-30 Mycartis N.V. Ltbp2 as a biomarker for predicting or prognosticating mortality
USD634426S1 (en) 2010-04-08 2011-03-15 Facet Technologies, Llc Lancing device
WO2011128357A2 (en) 2010-04-13 2011-10-20 Pronota N.V. Biomarkers for hypertensive disorders of pregnancy
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US10330667B2 (en) 2010-06-25 2019-06-25 Intuity Medical, Inc. Analyte monitoring methods and systems
US11382544B2 (en) 2011-08-03 2022-07-12 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
US11672452B2 (en) 2011-08-03 2023-06-13 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
US9782114B2 (en) 2011-08-03 2017-10-10 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
US11051734B2 (en) 2011-08-03 2021-07-06 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
US11395614B2 (en) 2012-01-25 2022-07-26 Tasso, Inc. Methods, systems, and devices relating to open microfluidic channels
US9204833B2 (en) 2012-03-27 2015-12-08 Phlebotics, Inc. Cartridge for automated blood sampling system
US10729386B2 (en) 2013-06-21 2020-08-04 Intuity Medical, Inc. Analyte monitoring system with audible feedback
US11071482B2 (en) 2014-06-26 2021-07-27 Stat Medical Devices, Inc. Lancet device with depth adjustment and lancet removal system and method
US10070811B2 (en) 2014-06-26 2018-09-11 Stat Medical Devices, Inc. Lancing device with depth adjustment and lancet removal system and method
US11998334B2 (en) 2014-08-01 2024-06-04 Tasso, Inc. Devices, systems and methods for gravity-enhanced microfluidic collection, handling and transferring of fluids
US12127837B2 (en) 2014-08-01 2024-10-29 Tasso, Inc. Devices, systems and methods for gravity-enhanced microfluidic collection, handling and transferring of fluids
US20180242895A1 (en) * 2015-05-25 2018-08-30 Coyote Bioscience Yixing Co., Ltd. Device and method for sample collection
US10702199B2 (en) 2015-06-17 2020-07-07 Hitachi High-Tech Corporation Blood collecting device
US11642057B2 (en) 2015-12-21 2023-05-09 Tasso, Inc. Devices, systems and methods for actuation and retraction in fluid collection
USD806246S1 (en) 2016-02-25 2017-12-26 Steven Schraga Lancet cover
US11510659B2 (en) * 2018-09-14 2022-11-29 Tasso, Inc. Bodily fluid collection devices and related methods
CN109647559A (en) * 2019-01-21 2019-04-19 上海陶术生物科技有限公司 A kind of full-automatic liquid relief station with anti-drip structure

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