US5441536A - Method for the production of an implant having an apatite coating layer using a hydrothermal treatment - Google Patents
Method for the production of an implant having an apatite coating layer using a hydrothermal treatment Download PDFInfo
- Publication number
- US5441536A US5441536A US07/969,227 US96922793A US5441536A US 5441536 A US5441536 A US 5441536A US 96922793 A US96922793 A US 96922793A US 5441536 A US5441536 A US 5441536A
- Authority
- US
- United States
- Prior art keywords
- hydrothermal treatment
- coating layer
- layer
- implant
- calcium phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/32—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/92—Method or apparatus for preparing or treating prosthetic
- Y10S623/923—Bone
Definitions
- the present invention relates to a method for the production of an implant.
- a plasma spraying method using hydroxyapatite as a starting material see, for example, KOKAI (Japanese Unexamined Patent Publication) No. 58-39533, KOKAI No. 62-34566).
- a method comprising the steps of preparing a powder formed mainly of a calcium salt and a phosphorus salt as a starting material, applying a coating film of the powder onto a metallic substrate by the plasma spraying technique, and immersing the coated metallic substrate in an atmosphere of steam or in water thereby converting the powder film into hydroxyapatite (see, for example, KOKAI No. 63-93851).
- thermo decomposition method (see, for example, KOKAI No. 64-86975).
- the method (1) mentioned above which uses hydroxyapatite as the starting material for plasma spraying proceeds through the steps of heating and cooling because of the operating principle of plasma flame spraying and tends to submit the hydroxyapatite to decomposition and, therefore, entails the following problems.
- Alkali components such as calcium oxide and tetracalcium phosphate persist as residues in the coating film.
- the method (2) mentioned above has the problem of not only rendering it difficult to form a single apatite phase from the calcium salt and phosphorus salt by the solid phase reaction recording to the plasma spraying technique but also submitting the reaction to the onset of decomposition. Even the immersion in an atmosphere of steam or in water lends no impetus to the reaction for conversion into a single hydroxyapatite phase but entails the disadvantage that the formation of calcium carbonate and other substances ensues, the solution advances, and the coating layer embrittles.
- the thermal decomposition method (3) mentioned above similarly to the plasma spraying method, has the problem of tending to form an amorphous phase of calcium oxide and tetracalcium phosphate and rendering it difficult for the coating layer to be converted into a single phase of stoichiometric hydroxyapatite. And, owing to the fact that the substrate itself is fired in the open air, this method also has the problem of giving rise to an oxide coating layer between the substrate and the HAP coating layer and, depending upon the firing conditions, the oxide coating layer becomes brittle and when the HAP coating layer is completely dissolved in a living body and consequently exposed to the vital tissue, inducing the occurrence of macrophage and foreign giant cells and causing a foreign reaction.
- an object of the present invention is to provide a method for quick and accurate production of an implant having an apatite type ceramic coating layer formed on the surface of a core material (substrate).
- a method for the production of an implant which comprises coating a core material with a calcium phosphate type compound and then converting the coating layer, by a hydrothermal treatment, into an apatite type ceramic layer.
- the present invention has succeeded in perfecting a method for producing an implant having as an outermost layer or coating layer thereof an accurate and stable stoichiometric hydroxyapatite and apatite type ceramic layer by forming on a core material (substrate) a coating layer of a calcium phosphate type compound by the process of, for example, plasma spraying, thermal decomposition, or sputtering and then submitting the resultant coated core material to a hydrothermal treatment.
- the terms "coating” and “coating film” are used synonomously.
- a calcium phosphate coating layer is first formed on the surface of a core material (substrate) by the process of, for example, plasma spraying, thermal decomposition, or sputtering. Then, the coating layer is hydrothermally treated in an aqueous solution simultaneously containing calcium ion and phosphate ion or an aqueous calcium phosphate solution or distilled water at a temperature in the range of, for example, between 80° C. and 200° C. for a period of between 0.5 and 100 hours.
- the material which has undergone this hydrothermal treatment has had the crystal structure thereof transformed into hydroxyapatite, which is confirmed by the X-ray diffraction process to constitute a single hydroxyapatite phase of very high crystallinity and is found by the IR absorption process and the Raman spectroscopy method to have a clear absorption by the hydroxyl group.
- the coating layer produced in the manner described above is an extremely stable chemical as evinced by the fact that it is substantially equal in solubility in physiological saline solution or simulated humor to a sintered stoichiometric hydroxyapatite article having the same surface area.
- implant refers to substitutes, prosthetics, reinforcements, etc., for such hard vital tissues as artificial roots of teeth, artificial bones, and bone plates, etc.
- the core material (referred to occasionally as “substrate” or “basic plate”), though variable in shape with the kind of implant aimed at, is made of a metallic material such as Ti type alloy or stainless steel or ceramic material.
- the calcium phosphate type compounds which are effectively usable in the method of the present invention include, for example, ⁇ - and ⁇ -tricalcium phosphates (TCP), octacalcium phosphate, and amorphous calcium phosphate. These calcium phosphate type compounds can be used either alone or in any mixture thereof.
- the formation of the calcium phosphate type coating layer may be attained by any of conventional processes such as, for example, plasma spraying process, baking process, thermal decomposition process, sputtering process, CVD process, and PVD process. It does not need to be limited to any specific coating means.
- the “hydrothermal treatment” involved in the method of the present invention refers to a procedure which comprises immersing a calcium phosphate-coated implant material in water such as an aqueous solution simultaneously containing calcium ion and phosphate ion, hermetically sealing the immersed implant material (in an atmosphere of such inert gas as air, nitrogen, or argon gas), and heating the sealed immersed implant material.
- the coating layer is enabled to be formed of a more stoichiometric hydroxyapatite.
- the term "stoichiometric hydroxyapatite” as used herein refers to Ca 10 (PO 4 ) 6 (OH) 2 .
- the conditions employed for the hydrothermal treatment and the solution used for the treatment are variable With a particular species of apatite layer aimed at.
- this hydrothermal treatment is desired to be performed in a solution simultaneously containing calcium ion and phosphate ion or an aqueous calcium phosphate solution or distilled water at a temperature of 200° C. or less, preferably falling in the range between 90° C. and 150° C., for a period of 100 hours or less, preferably falling in the range between 6 and 72 hours.
- the preparation of the components of the solution for the hydrothermal treatment and the setting of the temperature of treatment and the period of treatment are easy to attain.
- a varying species of apatite layer conforming to a particular purpose of use can be produced.
- the apatite type ceramic produced by the method of the present invention is such that the apatite type ceramic layer is allowed to have part of the metallic ions other than Ca and the anions other than PO 4 or OH (hydroxyl group) substituted by adjusting the components such as of the aqueous solution to be used for the hydrothermal treatment mentioned above.
- the coating layer may be formed of an apatite type ceramic substance (such as, for example, strontium apatite, magnesium apatite, chlorine apatite, fluorine apatite, or carbonate apatite) other than hydroxyapatite.
- a ⁇ -tricalcium phosphate (TCP)-metal composite material was obtained by forming a calcium phosphate coating layer on a metallic substrate (metal: titanium) by the plasma spraying process using TCP powder as the starting material for spraying.
- the composite material thus obtained was immersed in an aqueous solution simultaneously containing Ca 2+ and PO 4 3- ions at a pH value of 9.0 (which may be in the range of a pH of 6 to 12) (or in an aqueous calcium phosphate solution having a pH value in the range of 5.5 to 12.5), hermetically sealed, and subjected to a hydrothermal treatment at a temperature of 120° C. (which may be in the range between 80° C. and 200° C.).
- This hydrothermal treatment brought about transformation of crystal structure of the TCP layer into a HAP layer.
- the HAP layer formed a more stoichiometric chemically stable composition.
- a calcium phosphate coating layer was formed on a metallic substrate (metal: titanium) by the thermal decomposition process using a calcium salt and a phosphoric ester.
- the resultant composite material was fired at 500° C., a temperature not so high as to induce intense oxidation of the metallic substrate, for five hours to effect thorough combustion of existent carbon sources.
- the composite material thus obtained was immersed in an aqueous solution simultaneously containing Ca 2+ and PO 4 3- ions at a pH value of 7.5 (generally pH 6-12) (or in an aqueous calcium phosphate solution having a pH value in the range of 5.5 to 12.5), hermetically sealed, and hydrothermally treated at a temperature of 120° C. (generally in the range between 80° C. and 200° C.).
- the duration of this treatment was 12 hours (generally within 100 hours).
- the HAP layer in the composite material that underwent this hydrothermal treatment was formed of a more stoichiometric chemically stable composition.
- a TCP-metal composite material was obtained by forming a calcium phosphate coating layer on a metallic substrate (metal: stainless steel) by the plasma spraying process using TCP powder as the starting material for spraying.
- the composite material thus obtained was subjected to a hydrothermal treatment in a calcium carbonate sol.
- the temperature of this treatment was 120° C. (generally in the range between 80° C. and 200° C.) and the duration of the treatment was 48 hours (generally within 100 hours).
- An ⁇ -TCP sprayed layer-metal composite material was obtained by plasma spraying an ⁇ -TCP or ⁇ -TCP powder as the starting material for spraying on a metallic substrate (metal: stainless steel).
- the composite material thus obtained was immersed in an aqueous solution simultaneously containing Ca 2+ and PO 4 3- ions at a pH value of 7.0 (generally in the range between pH 6 and 12) (or in an aqueous calcium phosphate solution having a pH value in the range of 5.5 to 12.5), hermetically sealed, and hydrothermally treated at a temperature of 120° C. (generally in the range between 80° C. and 200° C.).
- the duration of-this treatment was 30 hours (generally within 100 hours).
- the surface of a Ti base intended for the root of a tooth was coarsened by sand blasting (or bead blasting or acid treatment) and subjected to plasma spraying using a ⁇ -TCP powder having a particle size distribution of 30 to 60 ⁇ m to form a coating layer of ⁇ -TCP thereon.
- a HAP gel prepared by dissolving in water a HAP synthesized by a wet process
- the coated base was immersed in such a manner as to keep the HAP particles from directly contacting the artificial root of a tooth and then subjected to a hydrothermal treatment at 120° C. for 30 hours. Consequently, there was obtained a composite material having the coating layer thereof transformed from the ⁇ -TCP layer into a HAP layer (confirmed by the X-ray powder diffraction process and the infrared absorption spectrometry process).
- the apatite type ceramic layer to be produced by the hydrothermal treatment is required to be formed at least in the outermost layer.
- the coating lay may be wholly formed of the apatite type ceramic substance.
- the method of according to the present invention for the production of an implant enables an apatite type ceramic layer represented by a chemically stable hydroxyapatite layer to be produced without resorting to the process of producing a calcium phosphate coating layer.
- an apatite type ceramic layer represented by a chemically stable hydroxyapatite layer to be produced without resorting to the process of producing a calcium phosphate coating layer.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Dental Prosthetics (AREA)
Abstract
An implant is produced by coating a core material with a calcium phosphate type compound and converting the coating layer into an apatite type ceramic layer by a hydrothermal treatment.
Description
The present invention relates to a method for the production of an implant.
The following methods have been typically known as ways of coating a metallic substrate with hydroxyapatite.
(1) A plasma spraying method using hydroxyapatite as a starting material (see, for example, KOKAI (Japanese Unexamined Patent Publication) No. 58-39533, KOKAI No. 62-34566).
(2) A method comprising the steps of preparing a powder formed mainly of a calcium salt and a phosphorus salt as a starting material, applying a coating film of the powder onto a metallic substrate by the plasma spraying technique, and immersing the coated metallic substrate in an atmosphere of steam or in water thereby converting the powder film into hydroxyapatite (see, for example, KOKAI No. 63-93851).
(3) A method comprising the steps of applying to the surface of a metallic substrate an organic-solvent coating liquid having an organic calcium compound and an organic phosphorus compound dissolved therein and heating and firing the coated metallic substrate thereby forming a hydroxyapatite coating film on the metallic substrate (thermal decomposition method) (see, for example, KOKAI No. 64-86975).
The method (1) mentioned above which uses hydroxyapatite as the starting material for plasma spraying proceeds through the steps of heating and cooling because of the operating principle of plasma flame spraying and tends to submit the hydroxyapatite to decomposition and, therefore, entails the following problems.
(a) Alkali components such as calcium oxide and tetracalcium phosphate persist as residues in the coating film.
(b) An amorphous phase occurs in the coating film.
(c) Since the alkali components and the amorphous layer mentioned above have high degrees of solubility and the coating layer of hydroxyapatite (HAP) itself succumbs to solution readily, the produced composite poses the problem of betraying deficiency in lasting biostability, yields to embrittlement in the course of solution, possibly suffers from a lopical increase in pH in a living body, and entails a problem of biocompatibility.
(d) Regarding the HAP layer, since the IR absorption spectrum of the-produced composite after separation therefrom of the HAP layer in a crushed form shows no discernible absorption peak originating in the hydroxyl group, this HAP layer does not deserve to be called a stoichiometric hydroxyapatite and poses the problem of offering no sufficient chemical stability.
The method (2) mentioned above has the problem of not only rendering it difficult to form a single apatite phase from the calcium salt and phosphorus salt by the solid phase reaction recording to the plasma spraying technique but also submitting the reaction to the onset of decomposition. Even the immersion in an atmosphere of steam or in water lends no impetus to the reaction for conversion into a single hydroxyapatite phase but entails the disadvantage that the formation of calcium carbonate and other substances ensues, the solution advances, and the coating layer embrittles.
The thermal decomposition method (3) mentioned above, similarly to the plasma spraying method, has the problem of tending to form an amorphous phase of calcium oxide and tetracalcium phosphate and rendering it difficult for the coating layer to be converted into a single phase of stoichiometric hydroxyapatite. And, owing to the fact that the substrate itself is fired in the open air, this method also has the problem of giving rise to an oxide coating layer between the substrate and the HAP coating layer and, depending upon the firing conditions, the oxide coating layer becomes brittle and when the HAP coating layer is completely dissolved in a living body and consequently exposed to the vital tissue, inducing the occurrence of macrophage and foreign giant cells and causing a foreign reaction.
Besides the methods cited above, methods such as sputtering and chemical vapor deposition are available for the coating of a metallic substrate with hydroxyapatite. These methods, however, have not been technically established as evinced by the fact that they experience great difficulty in obtaining calcium phosphate of high crystallinity.
Accordingly, an object of the present invention is to provide a method for quick and accurate production of an implant having an apatite type ceramic coating layer formed on the surface of a core material (substrate).
Other objects and advantages of the present invention will become apparent from the following description.
In accordance with the present invention, there is provided a method for the production of an implant which comprises coating a core material with a calcium phosphate type compound and then converting the coating layer, by a hydrothermal treatment, into an apatite type ceramic layer.
In the light of the true state of the prior art described above, the present invention has succeeded in perfecting a method for producing an implant having as an outermost layer or coating layer thereof an accurate and stable stoichiometric hydroxyapatite and apatite type ceramic layer by forming on a core material (substrate) a coating layer of a calcium phosphate type compound by the process of, for example, plasma spraying, thermal decomposition, or sputtering and then submitting the resultant coated core material to a hydrothermal treatment. In the present invention, the terms "coating" and "coating film" are used synonomously.
In accordance with the method of production contemplated by the present invention, a calcium phosphate coating layer is first formed on the surface of a core material (substrate) by the process of, for example, plasma spraying, thermal decomposition, or sputtering. Then, the coating layer is hydrothermally treated in an aqueous solution simultaneously containing calcium ion and phosphate ion or an aqueous calcium phosphate solution or distilled water at a temperature in the range of, for example, between 80° C. and 200° C. for a period of between 0.5 and 100 hours. The material which has undergone this hydrothermal treatment has had the crystal structure thereof transformed into hydroxyapatite, which is confirmed by the X-ray diffraction process to constitute a single hydroxyapatite phase of very high crystallinity and is found by the IR absorption process and the Raman spectroscopy method to have a clear absorption by the hydroxyl group. The coating layer produced in the manner described above is an extremely stable chemical as evinced by the fact that it is substantially equal in solubility in physiological saline solution or simulated humor to a sintered stoichiometric hydroxyapatite article having the same surface area.
When the calcium phosphate coating layer which has been formed by any of the processes cited above is subsequently treated hydrothermally in the same manner as described above in a solution simultaneously containing a metallic ion such as an alkali metal ion or alkaline earth metal ion and an anion of carbonic acid, nitric acid, sulfuric acid, boric acid, or halogen ion or in a solution containing any of the above-mentioned ions alone, it is converted into a material of apatite structure containing the relevant ions mentioned above. Thus, a novel implant material conforming to a particular purpose of use can be obtained.
The term "implant" as used in the present invention refers to substitutes, prosthetics, reinforcements, etc., for such hard vital tissues as artificial roots of teeth, artificial bones, and bone plates, etc.
The core material (referred to occasionally as "substrate" or "basic plate"), though variable in shape with the kind of implant aimed at, is made of a metallic material such as Ti type alloy or stainless steel or ceramic material.
The calcium phosphate type compounds which are effectively usable in the method of the present invention include, for example, α- and β-tricalcium phosphates (TCP), octacalcium phosphate, and amorphous calcium phosphate. These calcium phosphate type compounds can be used either alone or in any mixture thereof.
The formation of the calcium phosphate type coating layer may be attained by any of conventional processes such as, for example, plasma spraying process, baking process, thermal decomposition process, sputtering process, CVD process, and PVD process. It does not need to be limited to any specific coating means.
The "hydrothermal treatment" involved in the method of the present invention refers to a procedure which comprises immersing a calcium phosphate-coated implant material in water such as an aqueous solution simultaneously containing calcium ion and phosphate ion, hermetically sealing the immersed implant material (in an atmosphere of such inert gas as air, nitrogen, or argon gas), and heating the sealed immersed implant material. By this treatment, the coating layer is enabled to be formed of a more stoichiometric hydroxyapatite. The term "stoichiometric hydroxyapatite" as used herein refers to Ca10 (PO4)6 (OH)2.
The conditions employed for the hydrothermal treatment and the solution used for the treatment are variable With a particular species of apatite layer aimed at. For the purpose of mainly producing a single hydroxyapatite layer, this hydrothermal treatment is desired to be performed in a solution simultaneously containing calcium ion and phosphate ion or an aqueous calcium phosphate solution or distilled water at a temperature of 200° C. or less, preferably falling in the range between 90° C. and 150° C., for a period of 100 hours or less, preferably falling in the range between 6 and 72 hours.
In the present invention, the preparation of the components of the solution for the hydrothermal treatment and the setting of the temperature of treatment and the period of treatment (hereinafter these factors of the hydrothermal treatment may be occasionally referred to collectively as "environment of hydrothermal treatment") are easy to attain. Thus, a varying species of apatite layer conforming to a particular purpose of use can be produced.
The apatite type ceramic produced by the method of the present invention is such that the apatite type ceramic layer is allowed to have part of the metallic ions other than Ca and the anions other than PO4 or OH (hydroxyl group) substituted by adjusting the components such as of the aqueous solution to be used for the hydrothermal treatment mentioned above. Optionally, the coating layer may be formed of an apatite type ceramic substance (such as, for example, strontium apatite, magnesium apatite, chlorine apatite, fluorine apatite, or carbonate apatite) other than hydroxyapatite.
The present invention will now be further illustrated by, but is by no means limited to, the following Examples.
A α-tricalcium phosphate (TCP)-metal composite material was obtained by forming a calcium phosphate coating layer on a metallic substrate (metal: titanium) by the plasma spraying process using TCP powder as the starting material for spraying. The composite material thus obtained was immersed in an aqueous solution simultaneously containing Ca2+ and PO4 3- ions at a pH value of 9.0 (which may be in the range of a pH of 6 to 12) (or in an aqueous calcium phosphate solution having a pH value in the range of 5.5 to 12.5), hermetically sealed, and subjected to a hydrothermal treatment at a temperature of 120° C. (which may be in the range between 80° C. and 200° C.). The duration of this treatment was 24 hours (generally within 100 hours). This hydrothermal treatment brought about transformation of crystal structure of the TCP layer into a HAP layer. By the X-ray powder diffraction process and the infrared absorption spectrometry process, it was confirmed that the HAP layer formed a more stoichiometric chemically stable composition.
A calcium phosphate coating layer was formed on a metallic substrate (metal: titanium) by the thermal decomposition process using a calcium salt and a phosphoric ester. The resultant composite material was fired at 500° C., a temperature not so high as to induce intense oxidation of the metallic substrate, for five hours to effect thorough combustion of existent carbon sources. The composite material thus obtained was immersed in an aqueous solution simultaneously containing Ca2+ and PO4 3- ions at a pH value of 7.5 (generally pH 6-12) (or in an aqueous calcium phosphate solution having a pH value in the range of 5.5 to 12.5), hermetically sealed, and hydrothermally treated at a temperature of 120° C. (generally in the range between 80° C. and 200° C.). The duration of this treatment was 12 hours (generally within 100 hours). By the X-ray powder diffraction process and the infrared absorption spectrometry process, it was confirmed that the HAP layer in the composite material that underwent this hydrothermal treatment was formed of a more stoichiometric chemically stable composition.
A TCP-metal composite material was obtained by forming a calcium phosphate coating layer on a metallic substrate (metal: stainless steel) by the plasma spraying process using TCP powder as the starting material for spraying. The composite material thus obtained was subjected to a hydrothermal treatment in a calcium carbonate sol. The temperature of this treatment was 120° C. (generally in the range between 80° C. and 200° C.) and the duration of the treatment was 48 hours (generally within 100 hours). By the infrared absorption spectrometry process and the powder X-ray diffraction process, it was confirmed that, in consequence of the treatment described above, there was produced a composite material comprising an apatite coating layer having carbonic acid partially substituted at the position of the hydroxyl group of the hydroxyapatite structure and a metallic substrate.
An α-TCP sprayed layer-metal composite material was obtained by plasma spraying an α-TCP or β-TCP powder as the starting material for spraying on a metallic substrate (metal: stainless steel). The composite material thus obtained was immersed in an aqueous solution simultaneously containing Ca2+ and PO4 3- ions at a pH value of 7.0 (generally in the range between pH 6 and 12) (or in an aqueous calcium phosphate solution having a pH value in the range of 5.5 to 12.5), hermetically sealed, and hydrothermally treated at a temperature of 120° C. (generally in the range between 80° C. and 200° C.). The duration of-this treatment was 30 hours (generally within 100 hours). By the X-ray powder diffraction process and the infrared absorption spectrometry process, it was confirmed that the hydrothermal treatment caused transformation of crystal structure of the α-TCP layer into a HAP layer having a more stoichiometric chemically stable composition.
By controlling the duration of the hydrothermal treatment (for example, 1.5 hours at 120° C. in an aqueous solution simultaneously containing Ca2+ and PO4 3- ions at a pH value in the range between pH 6 and 12), there was obtained a composite material having the transformation into the HAP produced only in the surface region of the layer.
The surface of a Ti base intended for the root of a tooth was coarsened by sand blasting (or bead blasting or acid treatment) and subjected to plasma spraying using a β-TCP powder having a particle size distribution of 30 to 60 μm to form a coating layer of α-TCP thereon. In a HAP gel prepared by dissolving in water a HAP synthesized by a wet process, the coated base was immersed in such a manner as to keep the HAP particles from directly contacting the artificial root of a tooth and then subjected to a hydrothermal treatment at 120° C. for 30 hours. Consequently, there was obtained a composite material having the coating layer thereof transformed from the α-TCP layer into a HAP layer (confirmed by the X-ray powder diffraction process and the infrared absorption spectrometry process).
The apatite type ceramic layer to be produced by the hydrothermal treatment is required to be formed at least in the outermost layer. Of course, the coating lay may be wholly formed of the apatite type ceramic substance.
As described above, the method of according to the present invention for the production of an implant enables an apatite type ceramic layer represented by a chemically stable hydroxyapatite layer to be produced without resorting to the process of producing a calcium phosphate coating layer. By varying the environment of hydrothermal treatment, there can be formed an apatite type ceramic layer having part of the metallic ions and anions thereof substituted. Since the transformation of crystal structure is effected very quickly and accurately, the method permits mass production of the implant. The present invention, therefore, provides very high economic utility.
Claims (5)
1. A method for the production of an implant, consisting essentially of coating a core material with at least one calcium phosphate type compound selected from the group consisting of α-tricalcium phosphate and β-tricalcium phosphate by plasma spraying to form a coating layer on the core material and then, converting said coating layer into an apatite type ceramic layer by subjecting the coated core material to a hydrothermal treatment at a temperature of from 120° C. to 200° C. for from 0.5 to 100 hrs.
2. The method of claim 1, wherein said core material is a metallic substrate formed of a material selected from the group consisting of titanium, a titanium type alloy, stainless steel, a cobalt-chromium type alloy, and a nickel-titanium type alloy.
3. The method of claim 1, wherein said hydrothermal treatment is carried out in an aqueous solution that contains Ca ions and PO4 ions and has a pH value of from 6 to 12 at a temperature of from 120° C. to 150° C.
4. The method of claim 1, wherein said hydrothermal treatment is carried out in an aqueous calcium phosphate solution having a pH value of from 5.5 to 12.5 at a temperature of from 120° C. to 150° C.
5. The method of claim 1, wherein said hydrothermal treatment is carried out for from 12 to 100 hrs.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3-242899 | 1991-06-18 | ||
JP24289991A JP3198125B2 (en) | 1991-06-18 | 1991-06-18 | Manufacturing method of implant |
PCT/JP1992/000769 WO1992022335A1 (en) | 1991-06-18 | 1992-06-16 | Process for producing implant |
Publications (1)
Publication Number | Publication Date |
---|---|
US5441536A true US5441536A (en) | 1995-08-15 |
Family
ID=17095875
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/969,227 Expired - Lifetime US5441536A (en) | 1991-06-18 | 1992-06-16 | Method for the production of an implant having an apatite coating layer using a hydrothermal treatment |
Country Status (6)
Country | Link |
---|---|
US (1) | US5441536A (en) |
EP (1) | EP0548365B1 (en) |
JP (1) | JP3198125B2 (en) |
CA (1) | CA2088263C (en) |
DE (1) | DE69228793T2 (en) |
WO (1) | WO1992022335A1 (en) |
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997041273A1 (en) * | 1996-04-30 | 1997-11-06 | Flametal S.P.A. | Process for the preparation of hydroxyapatite coatings |
US5730598A (en) * | 1997-03-07 | 1998-03-24 | Sulzer Calcitek Inc. | Prosthetic implants coated with hydroxylapatite and process for treating prosthetic implants plasma-sprayed with hydroxylapatite |
US5993214A (en) * | 1994-10-04 | 1999-11-30 | Nobel Biocare Ab | Method for manufacture of a dental product |
US6113993A (en) * | 1998-10-28 | 2000-09-05 | Battelle Memorial Institute | Method of coating a substrate with a calcium phosphate compound |
US6139585A (en) * | 1998-03-11 | 2000-10-31 | Depuy Orthopaedics, Inc. | Bioactive ceramic coating and method |
US20010004711A1 (en) * | 1994-11-30 | 2001-06-21 | Richard J. Lazzara | Infection-blocking dental implant |
US6319255B1 (en) * | 1996-12-18 | 2001-11-20 | Eska Implants Gmbh & Co. | Prophylactic implant against fracture of osteoporosis-affected bone segments |
US20030099762A1 (en) * | 2001-10-12 | 2003-05-29 | Zongtao Zhang | Coatings, coated articles and methods of manufacture thereof |
US6736849B2 (en) | 1998-03-11 | 2004-05-18 | Depuy Products, Inc. | Surface-mineralized spinal implants |
US20040148031A1 (en) * | 1994-11-30 | 2004-07-29 | Beaty Keith D. | Implant surface preparation |
US20040153165A1 (en) * | 2003-01-31 | 2004-08-05 | Depuy Products, Inc. | Biological agent-containing ceramic coating and method |
EP1481696A2 (en) * | 2003-05-30 | 2004-12-01 | Depuy Products, Inc. | Implantable articles with strontium-substituted apatite coating |
US20040265780A1 (en) * | 2003-05-16 | 2004-12-30 | Robb T. Tait | Surface treatment process for implants made of titanium alloy |
US20070108162A1 (en) * | 1994-11-30 | 2007-05-17 | Beaty Keith D | Implant surface preparation |
US20100174382A1 (en) * | 2007-07-09 | 2010-07-08 | Astra Tech Ab | Bone tissue implant comprising strontium ions |
US20100243429A1 (en) * | 2007-12-11 | 2010-09-30 | Yamahachi Dental Mfg., Co. | Method of manufacturing implant and method of manufacturing artificial dental root |
US20100262244A1 (en) * | 2009-04-14 | 2010-10-14 | Warsaw Orthopedic, Inc. | Metal Coated Implant |
US20110059425A1 (en) * | 2009-09-04 | 2011-03-10 | The Procter & Gamble Company | Apparatus and methods for visual demonstration of dental erosion on simulated dental materials |
US20110151026A1 (en) * | 2007-07-09 | 2011-06-23 | Astra Tech Ab | Bone tissue implant comprising lithium ions |
US20120141775A1 (en) * | 2009-05-28 | 2012-06-07 | Rrg Coatings Limited | Coating method |
WO2023159885A1 (en) * | 2022-02-22 | 2023-08-31 | 宁波市医疗中心李惠利医院 | Preparation method for slowly-degradable high-purity magnesium anchor |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5763092A (en) * | 1993-09-15 | 1998-06-09 | Etex Corporation | Hydroxyapatite coatings and a method of their manufacture |
ES2088767B1 (en) * | 1994-05-31 | 1997-03-16 | Consejo Superior Investigacion | PROCEDURE FOR SURFACE COATING WITH HYDROXIAPATITE OF METALLIC IMPLANTS. |
FR2731909B1 (en) * | 1995-03-20 | 1997-06-20 | Euros Sa | NOVEL BIOCOMPATIBLE PROSTHETIC MATERIAL, PROSTHESIS OR PROSTHETIC SYSTEMS CONSTITUTED BY SAID MATERIAL AND THEIR PREPARATION PROCESS BY DUAL IONIC IMPLANTATION OF CALCIUM AND PHOSPHORUS. |
DE19630034A1 (en) * | 1996-07-25 | 1998-04-23 | Huels Chemische Werke Ag | Biohybrid dental implant |
FR2772746B1 (en) * | 1997-12-23 | 2000-01-28 | Commissariat Energie Atomique | PROCESS FOR THE MANUFACTURE OF AN APATITIC CERAMIC, PARTICULARLY FOR BIOLOGICAL USE |
US6958355B2 (en) | 2000-04-24 | 2005-10-25 | Aryx Therapeutics, Inc. | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
JP4685277B2 (en) * | 2001-06-20 | 2011-05-18 | 独立行政法人物質・材料研究機構 | Method for coating biological tissue substrate |
EP1293219A1 (en) * | 2001-09-17 | 2003-03-19 | Matthias Prof. Dr. Epple | Biomedical product with a substrate comprising a nickel-titanium alloy and a coating layer comprising calcium phosphate |
CN1314466C (en) * | 2004-01-16 | 2007-05-09 | 东南大学 | Nickel and titanium non-bloodvessel lumen bracket with calcium and phosphor ceramic deposited on surface and its preparing method |
CA2558395C (en) | 2004-03-10 | 2011-11-29 | Scil Technology Gmbh | Coated implants, their manufacturing and use thereof |
KR20060030370A (en) * | 2004-10-05 | 2006-04-10 | 주식회사 엘지화학 | Method for preparation of bioactive ceramic-coated composite |
KR100775537B1 (en) | 2007-07-19 | 2007-11-28 | (주)오스테오필 | Method of fabricating implant with improved surface properties and implant fabiricated by the same method |
CA2702209A1 (en) * | 2007-10-10 | 2009-04-16 | Miv Therapeutics Inc. | Calcium phosphate coated stents comprising cobalt chromium alloy |
CN102677126B (en) * | 2012-05-25 | 2015-05-27 | 西安交通大学 | Process for preparing compact magnesium oxide/hydroxyapatite nano fiber double-layer coating on surface of magnesium base |
JP5891150B2 (en) | 2012-09-07 | 2016-03-22 | 株式会社アドバンス | Method for producing dental implant |
CN110115777A (en) * | 2019-05-29 | 2019-08-13 | 扬州大学 | The preparation method for having the titanium alloy material of good biocompatibility and bacteria resistance function coating |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5839533A (en) * | 1981-08-13 | 1983-03-08 | シア−ズ・マニユフアクチヤリング・カンパニ− | Supporting and suspension system for seat |
JPS5951485A (en) * | 1982-09-18 | 1984-03-24 | Japan Storage Battery Co Ltd | Charging process of enclosed lead storage battery |
DE3709457A1 (en) * | 1986-03-24 | 1987-10-01 | Permelec Electrode Ltd | TITANIUM COMPOSITES COATED WITH A CALCIUM PHOSPHATE COMPOUND AND METHOD FOR THE PRODUCTION THEREOF |
JPS6338443A (en) * | 1986-08-01 | 1988-02-19 | ティーディーケイ株式会社 | Implant for artificial dental root and its production |
JPS63160666A (en) * | 1986-12-25 | 1988-07-04 | 日本特殊陶業株式会社 | Ceramic coated implant |
EP0285826A2 (en) * | 1987-04-04 | 1988-10-12 | BK LADENBURG GmbH, Gesellschaft für chemische Erzeugnisse | Implant with a bioactive coating |
EP0407698A1 (en) * | 1989-05-08 | 1991-01-16 | Helmut Dr. Heide | Method for making an implantable bone prosthesis based on hydroxyapatite |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5839533B2 (en) * | 1975-12-30 | 1983-08-30 | 住友化学工業株式会社 | Implant noseizouhouhou |
JPS5951485B2 (en) * | 1977-03-11 | 1984-12-14 | 東京医科歯科大学長 | Production method of CaO-P↓2O↓5-based apatite |
-
1991
- 1991-06-18 JP JP24289991A patent/JP3198125B2/en not_active Expired - Fee Related
-
1992
- 1992-06-16 US US07/969,227 patent/US5441536A/en not_active Expired - Lifetime
- 1992-06-16 EP EP92911104A patent/EP0548365B1/en not_active Expired - Lifetime
- 1992-06-16 WO PCT/JP1992/000769 patent/WO1992022335A1/en active IP Right Grant
- 1992-06-16 CA CA002088263A patent/CA2088263C/en not_active Expired - Fee Related
- 1992-06-16 DE DE69228793T patent/DE69228793T2/en not_active Expired - Fee Related
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5839533A (en) * | 1981-08-13 | 1983-03-08 | シア−ズ・マニユフアクチヤリング・カンパニ− | Supporting and suspension system for seat |
JPS5951485A (en) * | 1982-09-18 | 1984-03-24 | Japan Storage Battery Co Ltd | Charging process of enclosed lead storage battery |
DE3709457A1 (en) * | 1986-03-24 | 1987-10-01 | Permelec Electrode Ltd | TITANIUM COMPOSITES COATED WITH A CALCIUM PHOSPHATE COMPOUND AND METHOD FOR THE PRODUCTION THEREOF |
US4882196A (en) * | 1986-03-24 | 1989-11-21 | Permelec Electrode Ltd. | Process for the production of a titanium composite materials coated with calcium phosphate compound |
US4960646A (en) * | 1986-03-24 | 1990-10-02 | Permelec Electrode Ltd. | Titanium composite materials coated with calcium phosphate compound |
US5141576A (en) * | 1986-03-24 | 1992-08-25 | Permelec Electrode, Ltd. | Titanium composite materials coated with calcium phosphate compound and process for production thereof |
JPS6338443A (en) * | 1986-08-01 | 1988-02-19 | ティーディーケイ株式会社 | Implant for artificial dental root and its production |
JPS63160666A (en) * | 1986-12-25 | 1988-07-04 | 日本特殊陶業株式会社 | Ceramic coated implant |
EP0285826A2 (en) * | 1987-04-04 | 1988-10-12 | BK LADENBURG GmbH, Gesellschaft für chemische Erzeugnisse | Implant with a bioactive coating |
US4871578A (en) * | 1987-04-04 | 1989-10-03 | Mtu Motoren- Und Turbinen-Union Muenchen Gmbh | Hydroxylapatite coating on metal or ceramic |
EP0407698A1 (en) * | 1989-05-08 | 1991-01-16 | Helmut Dr. Heide | Method for making an implantable bone prosthesis based on hydroxyapatite |
Cited By (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5993214A (en) * | 1994-10-04 | 1999-11-30 | Nobel Biocare Ab | Method for manufacture of a dental product |
US7547399B2 (en) * | 1994-11-30 | 2009-06-16 | Biomet 3I, Llc | Implant surface preparation |
US20080135521A1 (en) * | 1994-11-30 | 2008-06-12 | Beaty Keith D | Implant surface preparation |
US20070108162A1 (en) * | 1994-11-30 | 2007-05-17 | Beaty Keith D | Implant surface preparation |
US7169317B2 (en) | 1994-11-30 | 2007-01-30 | Implant Innovations, Inc. | Implant surface preparation |
US20010004711A1 (en) * | 1994-11-30 | 2001-06-21 | Richard J. Lazzara | Infection-blocking dental implant |
US20080160168A1 (en) * | 1994-11-30 | 2008-07-03 | Beaty Keith D | Implant surface preparation |
US6969474B2 (en) | 1994-11-30 | 2005-11-29 | Implant Innovations, Inc. | Implant surface preparation |
US8221499B2 (en) | 1994-11-30 | 2012-07-17 | Biomet 3I, Llc | Infection-blocking dental implant |
US7550091B2 (en) | 1994-11-30 | 2009-06-23 | Biomet 3I, Llc | Implant surface preparation |
US20040148031A1 (en) * | 1994-11-30 | 2004-07-29 | Beaty Keith D. | Implant surface preparation |
US7857987B2 (en) | 1994-11-30 | 2010-12-28 | Biomet 3I, Llc | Implant surface preparation |
US6280789B1 (en) * | 1996-04-30 | 2001-08-28 | Biocoatings S.R.L. | Process for preparation of hydroxyapatite coatings |
WO1997041273A1 (en) * | 1996-04-30 | 1997-11-06 | Flametal S.P.A. | Process for the preparation of hydroxyapatite coatings |
US6319255B1 (en) * | 1996-12-18 | 2001-11-20 | Eska Implants Gmbh & Co. | Prophylactic implant against fracture of osteoporosis-affected bone segments |
US5730598A (en) * | 1997-03-07 | 1998-03-24 | Sulzer Calcitek Inc. | Prosthetic implants coated with hydroxylapatite and process for treating prosthetic implants plasma-sprayed with hydroxylapatite |
US6139585A (en) * | 1998-03-11 | 2000-10-31 | Depuy Orthopaedics, Inc. | Bioactive ceramic coating and method |
US6736849B2 (en) | 1998-03-11 | 2004-05-18 | Depuy Products, Inc. | Surface-mineralized spinal implants |
US6569489B1 (en) | 1998-03-11 | 2003-05-27 | Depuy Orthopaedics, Inc. | Bioactive ceramic coating and method |
US6113993A (en) * | 1998-10-28 | 2000-09-05 | Battelle Memorial Institute | Method of coating a substrate with a calcium phosphate compound |
US20030099762A1 (en) * | 2001-10-12 | 2003-05-29 | Zongtao Zhang | Coatings, coated articles and methods of manufacture thereof |
US20060204542A1 (en) * | 2001-10-12 | 2006-09-14 | Zongtao Zhang | Coatings, Coated articles and methods of manufacture thereof |
US20060204541A1 (en) * | 2001-10-12 | 2006-09-14 | Zongtao Zhang | Coatings, coated articles and methods of manufacture thereof |
US7157096B2 (en) | 2001-10-12 | 2007-01-02 | Inframat Corporation | Coatings, coated articles and methods of manufacture thereof |
US7320799B2 (en) | 2001-10-12 | 2008-01-22 | Inframat Corporation | Coatings, coated articles and methods of manufacture thereof |
US7320798B2 (en) | 2001-10-12 | 2008-01-22 | Inframat Corporation | Coatings, coated articles and methods of manufacture thereof |
US7087086B2 (en) * | 2003-01-31 | 2006-08-08 | Depuy Products, Inc. | Biological agent-containing ceramic coating and method |
US20040153165A1 (en) * | 2003-01-31 | 2004-08-05 | Depuy Products, Inc. | Biological agent-containing ceramic coating and method |
AU2004200224B2 (en) * | 2003-01-31 | 2010-03-25 | Depuy Products, Inc. | Biological agent-containing ceramic coating and method |
US8251700B2 (en) | 2003-05-16 | 2012-08-28 | Biomet 3I, Llc | Surface treatment process for implants made of titanium alloy |
US10227697B2 (en) | 2003-05-16 | 2019-03-12 | Biomet 3I, Llc | Surface treatment process for implants made of titanium alloy |
US11015253B2 (en) | 2003-05-16 | 2021-05-25 | Biomet 3I, Llc | Surface treatment process for implants made of titanium alloy |
US20040265780A1 (en) * | 2003-05-16 | 2004-12-30 | Robb T. Tait | Surface treatment process for implants made of titanium alloy |
US20040241314A1 (en) * | 2003-05-30 | 2004-12-02 | Depuy Products, Inc. | Strontium-substituted apatite coating |
EP1481696A2 (en) * | 2003-05-30 | 2004-12-01 | Depuy Products, Inc. | Implantable articles with strontium-substituted apatite coating |
US20050208097A1 (en) * | 2003-05-30 | 2005-09-22 | Depuy Products, Inc. | Strontium-substituted apatite coating |
EP1481696A3 (en) * | 2003-05-30 | 2004-12-29 | Depuy Products, Inc. | Implantable articles with strontium-substituted apatite coating |
US6905723B2 (en) | 2003-05-30 | 2005-06-14 | Depuy Products, Inc. | Strontium-substituted apatite coating |
US8067069B2 (en) | 2003-05-30 | 2011-11-29 | Depuy Products, Inc. | Strontium-substituted apatite coating |
US20110151026A1 (en) * | 2007-07-09 | 2011-06-23 | Astra Tech Ab | Bone tissue implant comprising lithium ions |
US20100174382A1 (en) * | 2007-07-09 | 2010-07-08 | Astra Tech Ab | Bone tissue implant comprising strontium ions |
US9889227B2 (en) | 2007-07-09 | 2018-02-13 | Astra Tech Ab | Bone tissue implant comprising strontium ions |
US9744263B2 (en) | 2007-07-09 | 2017-08-29 | Astra Tech Ab | Bone tissue implant comprising strontium ions |
US8597676B2 (en) | 2007-07-09 | 2013-12-03 | Astra Tech Ab | Bone tissue implant comprising lithium ions |
US20100243429A1 (en) * | 2007-12-11 | 2010-09-30 | Yamahachi Dental Mfg., Co. | Method of manufacturing implant and method of manufacturing artificial dental root |
US8834233B2 (en) * | 2007-12-11 | 2014-09-16 | Yamahachi Dental Mfg., Co. | Method of manufacturing implant and method of manufacturing artificial dental root |
US20100262244A1 (en) * | 2009-04-14 | 2010-10-14 | Warsaw Orthopedic, Inc. | Metal Coated Implant |
US9237989B2 (en) * | 2009-05-28 | 2016-01-19 | Taragenyx Limited | Coating method |
US9421151B2 (en) | 2009-05-28 | 2016-08-23 | Taragenyx Limited | Coating method |
US20120141775A1 (en) * | 2009-05-28 | 2012-06-07 | Rrg Coatings Limited | Coating method |
US9087457B2 (en) | 2009-09-04 | 2015-07-21 | The Procter & Gamble Company | Apparatus and methods for visual demonstration of dental erosion on simulated dental materials |
CN102713991B (en) * | 2009-09-04 | 2015-05-13 | 宝洁公司 | Apparatus and methods for visual demonstration of dental erosion on simulated dental materials |
CN102713991A (en) * | 2009-09-04 | 2012-10-03 | 宝洁公司 | Apparatus and methods for visual demonstration of dental erosion on simulated dental materials |
WO2011028758A3 (en) * | 2009-09-04 | 2012-06-28 | The Procter & Gamble Company | Apparatus and methods for visual demonstration of dental erosion on simulated dental materials |
US10262556B2 (en) | 2009-09-04 | 2019-04-16 | The Procter & Gamble Company | Apparatus and methods for visual demonstration of dental erosion on simulated dental materials |
US20110059425A1 (en) * | 2009-09-04 | 2011-03-10 | The Procter & Gamble Company | Apparatus and methods for visual demonstration of dental erosion on simulated dental materials |
WO2023159885A1 (en) * | 2022-02-22 | 2023-08-31 | 宁波市医疗中心李惠利医院 | Preparation method for slowly-degradable high-purity magnesium anchor |
Also Published As
Publication number | Publication date |
---|---|
DE69228793D1 (en) | 1999-05-06 |
DE69228793T2 (en) | 1999-11-11 |
CA2088263A1 (en) | 1992-12-19 |
EP0548365B1 (en) | 1999-03-31 |
EP0548365A1 (en) | 1993-06-30 |
CA2088263C (en) | 1999-01-19 |
JP3198125B2 (en) | 2001-08-13 |
EP0548365A4 (en) | 1993-10-27 |
JPH04371146A (en) | 1992-12-24 |
WO1992022335A1 (en) | 1992-12-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5441536A (en) | Method for the production of an implant having an apatite coating layer using a hydrothermal treatment | |
CA2150036C (en) | A material for a bone substitute and the manufacturing method thereof | |
US5171326A (en) | Calcium phosphate ceramics for bone tissue calcification enhancement | |
Cao et al. | Water vapour-treated hydroxyapatite coatings after plasma spraying and their characteristics | |
DE3750849T2 (en) | SOLID CALCIUM PHOSPHATE MATERIALS. | |
US6280789B1 (en) | Process for preparation of hydroxyapatite coatings | |
US20050279252A1 (en) | Tetracalcium phosphate (TTCP) with surface whiskers and method of making same | |
Garcia et al. | Effect of heat treatment on pulsed laser deposited amorphous calcium phosphate coatings | |
EP2444027B2 (en) | Method for coating an implant with net-shaped or island-shaped low-crystallized hydroxyapatite | |
Yamashita et al. | Electrophoretic coating of multilayered apatite composite on alumina ceramics | |
US7351433B2 (en) | Method for producing polymeric sol of calcium phosphate compound and method for coating the same on a metal implant | |
Tucker et al. | Pre-conditioning and dual constant composition dissolution kinetics of pulsed laser deposited hydroxyapatite thin films on silicon substrates | |
Allen et al. | Surface and bulk study of calcium phosphate bioceramics obtained by Metal Organic Chemical Vapor Deposition | |
Torrisi | Structural investigations on laser deposited hydroxyapatite films | |
JP3076637B2 (en) | Composite implant | |
Dos Santos et al. | Sol–gel based calcium phosphates coatings deposited on binary Ti–Mo alloys modified by laser beam irradiation for biomaterial/clinical applications | |
JP3165981B2 (en) | Composite implant material and method for producing the same | |
JPS62266065A (en) | Living body compatible laminar substance containing calcium phosphate and its production | |
Barinov et al. | Composite coatings based on low-temperature calcium phosphates for intraosseous implants | |
Dos Santos et al. | Biomimetic calcium phosphates-based coatings deposited on binary Ti-Mo alloys modified by laser beam irradiation for biomaterial/clinical applications | |
JP2000143219A (en) | Production of calcium phosphate material | |
Klyui et al. | Gas detonation deposition technology–new prospectives for production of Ca-phosphate biocompatible coatings onto medical implants | |
US7156915B2 (en) | Tetracalcium phosphate (TTCP) with surface whiskers and method of making same | |
Afshar et al. | A STUDY OF ZETA POTENTIAL OF PLASMA SPRAYED HYDROXY AP ATITE COATING IN FOUR SIMULATED PHYSIOLOGICAL SOLUTIONS | |
CN109179356A (en) | A kind of method that titanium or titanium alloy surface prepare hydroxyapatite coating layer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: KABUSHIKI KAISYA ADVANCE, JAPAN Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:AOKI, HIDEKI;AKAO, MASARU;SHIN, YOSHIHARU;AND OTHERS;REEL/FRAME:006558/0111 Effective date: 19930108 |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
CC | Certificate of correction | ||
FEPP | Fee payment procedure |
Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
FPAY | Fee payment |
Year of fee payment: 4 |
|
FPAY | Fee payment |
Year of fee payment: 8 |
|
FPAY | Fee payment |
Year of fee payment: 12 |
|
REMI | Maintenance fee reminder mailed |