US5428050A - Synergistic water soluble preservative compositions of biocidal mixtures - Google Patents
Synergistic water soluble preservative compositions of biocidal mixtures Download PDFInfo
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- US5428050A US5428050A US08/234,089 US23408994A US5428050A US 5428050 A US5428050 A US 5428050A US 23408994 A US23408994 A US 23408994A US 5428050 A US5428050 A US 5428050A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
Definitions
- This invention relates to a water soluble preservative admixture for addition to commercial use formulations to provide long time synergistic biocidal activity therein, and, more particularly, to admixtures of a methylol compound and an iodopropynyl compound, in predetermined weight ratios of 100:1 to 2000:1.
- M. Rosen et al. in U.S. Pat. No. 4,844,891, for example, described a preservative admixture of (a) a formaldehyde donor and (b) a halopropynyl compound, in a weight ratio of (a):(b) of 50:1 to 1:1, preferably 30:1 to 2:1, and, most preferably, 20:1 to 10:1, as providing fungicidal activity for 1-3 days in commercial use formulations.
- a feature of the present invention is the provision of an admixture concentrate which is water soluble and which therefore can be uniformly distributed in use compositions at a predetermined use level.
- Another feature herein is the provision of a preservative admixture which exhibits a long term synergistic biocidal activity against wide range of fungi and both gram-negative and gram-positive bacteria in the use compositions.
- Still another feature of this invention is the provision of a water soluble preservative admixture for personal care compositions in the form of a solution, lotion, gel, emulsion, emulsifiable concentrate, suspension, slurry or cream.
- composition of the invention comprises an admixture of powders of
- compositions containing about 0.01 to 2% by weight of the composition of the invention also are provided therein.
- Such use compositions contain an iodopropynyl compound in an amount of about 0.5 to 10 ppm, to provide the desired antifungal activity, and a methylol compound, or equivalent thereof, in an amount of at least 250 ppm, to provide the desired antibacterial activity.
- the invention is based upon the discoveries that in a predetermined admixture of (a) a methylol compound, or its equivalent, and (b) an iodopropynyl compound:
- Iodopropynyl compounds are substantially water insoluble at weight ratios of (a):(b) of less than 100; accordingly, at weight ratios below 100:1, it is difficult to uniformly distribute the iodopropynyl compound in aqueous use compositions, particularly in creams, gels and the like.
- the admixtures are used at a weight ratio of (a):(b) of 100:1 to 2000:1, which are water soluble in all use compositions at conventional use levels.
- Preservative activity for use compositions is achieved most effectively with an admixture wt. ratio of 100:1 to 2000:1 at use levels of 0.05 to 2% by weight of the finished product.
- the iodopropynyl compound is present in an amount of only 0.5-10 ppm, which significantly reduces the cost and toxicity of the use composition.
- the methylol compound also is present in an amount of at least 250 ppm.
- the (a) methylol compound may be selected from diazolidinyl urea.
- Tables 1 through 14 below demonstrate the very effective synergistic interaction between compounds "a” and "b” against a broad range of fungi and both gram-negative and gram-positive bacteria. The following organisms were tested:
- Q b The quantity of Compound b acting alone, producing and endpoint.
- Q A The quantity of Compound A in mixture, producing an endpoint.
- Q B The quantity of Compound in mixture, producing an endpoint.
- SI is equal to 1a mere additive effect of the components in the mixture is indicated; when SI is less than 1, synergism has occurred; and when SI is greater than 1 it indicates antagonism of the two components.
- the quantity of each component in the various mixtures is compared with the, quantity of pure component that is required to reach the same endpoint or to produce the same microbiological effect as the mixture.
- Tables 1 through 14 above illustrate the synergism of IPBC (compound B) with Germall® II or DMDMH (compound A) at weight ratios of A:B of 2000:1, 1000:1, 500:1, 200:1, 100:1, 50:1 and 20:1.
- Synergism is very effective for all ratios at low use levels, e.g. 0.01% to 0.1%, against all tested gram-positive, gram-negative organisms and fungi organisms. At slightly higher use concentrations, e.g. 0.20 to 0.50%, all tested ratios were synergistic against Candida albicans and A. niger also.
- the synergistic effect is negligible at the 0.01 to 0.1% use levels, and non-synergistic even against Candida albicans and A. niger at use levels of 0.20 to 0.50%.
- the SI values were lower for Germall® II as the methylol compound in the admixtures as compared to DMDMH.
- IPGA iodopropynyl alcohol
- a typical cosmetic emulsion was prepared for microbiological Challenge testing and predetermined admixtures of a methylol compound and IPBC were added at various use levels.
- the emulsion thus prepared had the following composition:
- Phases A and B were heated separately to 75°-80° C. Phase A then was added to Phase B with mixing. The mixture then was cooled to 55°-60° C. At this point the desired amount of the preservative admixture was added and the product was cooled to 50° C. while stirring. The citric acid solution then was added to adjust the pH and the mixture was stirred until a temperature of 30° C. was reached.
- the challenge tests were carried out using the following microorganisms: SA, ECOLI, PSA, PC, AN and CAN, in this manner. 50 g. aliquots of the test emulsion containing various amounts of the preservative admixture were inoculated with approximately 10 7 -10 8 of the challenge organisms. The test samples then were stirred to disperse the challenge inoculum. The samples were incubated and assayed at 48 hours, 7, 14, 21 and 28 days. The assays were performed on 1 g. of the test sample by serially diluting 10 1 to 10 6 of the original concentration. The plating medium for bacteria was Letheen agar and for fungi it was low pH Mycophil agar with Tween 20.
- admixture compositions of Germall® II and IPBC at a wt. ratio of 2000:1 provide substantially complete protection against all tested organisms after 28 days.
- all the challenge tests passed within 21 days.
- all organisms died within 7 days except CAN which cleared within 14 days.
- Table 21 shows the challenge test results for DMDMH and IPBC admixtures at the same 2000:1 wt. ratio. A use level of 0.2%, however is needed for this blend to pass against all organisms after 21 days. Upon reinoculation, all organisms died within 7 days with the exception of CAN which cleared within 14 days. It is thus evident from these results that Germall® II blended with IPBC is 4 times more effective than a DMDMH/IPBC blend
- Germall® II also is superior to GADM as the methylol compound, as shown in Table 23.
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- Health & Medical Sciences (AREA)
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Abstract
Description
TABLE A ______________________________________ Weight Ratio of Amount Germall ® II:IPBC in ppm Solubility ______________________________________ 2000:1 5 Soluble 1000:1 10 Soluble 500:1 20 Soluble 200:1 50 Soluble 100:1 100 Soluble 50:1 200 Insoluble 20:1 500 Insoluble ______________________________________
TABLE B ______________________________________ Weight Ratio of Amount GADM: IPBC in ppm Solubility ______________________________________ 2000:1 5 Soluble 1000:1 10 Soluble 500:1 20 Soluble 500:1 50 Soluble 100:1 100 Soluble 50:1 200 Insoluble 20:1 500 Insoluble ______________________________________
TABLE C ______________________________________ Weight Ratio of Amount DMDMH: IPBC in ppm Solubility ______________________________________ 2000:1 5 Soluble 1000:1 10 Soluble 500:1 20 Soluble 200:1 50 Soluble 100:1 100 Soluble 50:1 200 Insoluble 20:1 500 Insoluble ______________________________________
______________________________________ ATCC Organism Number Inoculum Concentration ______________________________________ Ps. aeruginosa (PSA)* 9027 2.1 × 10.sup.6 CFU/gm of Product E. coli (ECOLI)* 8739 4.7 × 10.sup.5 CFU/gm of Product Staph. aureus (SA)** 6538 1.6 × 10.sup.6 CFU/gm of Product Ps. cepacia (PC)* 25416 1.6 × 10.sup.6 CFU/gm of Product C. albicans (CAN)*** 10231 8.0 × 10.sup.4 CFU/gm of Product A. niger (AN)*** 16404 2.7 × 10.sup.5 CFU/gm of Product ______________________________________
TABLE D __________________________________________________________________________ Static (MIC) and Cidal Activities of Several Antimicrobial Compounds (Static/Cidal Concentrations in ppm) Organism (ATCC #) IPBC Germall ® II GADM DMDMH IPGA __________________________________________________________________________ (SA) (6538) 100/200 400/1600 400/800 450/1600 300/5000 (ECOLI) (8739) 50/100 400/1600 400/800 400/800 150/600 (PSA) (9027) 800/1200 400/1600 400/400 600/1600 70/70 (PC) (25416) 1200/1800 200/400 200/400 600/1600 70/300 (CAN) (10231) 50/100 1500/15000 7500/15000 8000/16000 50/300 (AN) (16404) 50/100 3200/3200 1600/3200 8000/16000 30/30 __________________________________________________________________________
TABLE 1 ______________________________________ 2000:1 Wt. Ratio GERMALL ® II/IPBC Use Level Organism Q.sub.a Q.sub.b Q.sub.A Q.sub.B SI ______________________________________ 0.01% SA 200 1600 0.05 99.95 0.06 " ECOLI 100 1600 0.05 99.95 0.06 " PSA 1200 1600 0.05 99.95 0.06 " PC 1800 1250 0.05 99.95 0.08 " CAN 100 15000 0.05 99.95 0.01 " AN 100 3200 0.05 99.95 0.03 0.025% SA 200 1600 0.125 249.9 0.16 " ECOLI 100 1600 0.125 249.9 0.16 " PSA 1200 1600 0.125 249.9 0.16 " PC 1800 1250 0.125 249.9 0.20 " CAN 100 15000 0.125 249.9 0.02 " AN 100 3200 0.125 249.9 0.08 0.05% SA 200 1600 0.25 499.8 0.31 " ECOLI 100 1600 0.25 499.8 0.31 " PSA 1200 1600 0.25 499.8 0.31 " PC 1800 1250 0.25 499.8 0.40 " CAN 100 15000 0.25 499.8 0.04 " AN 100 3200 0.25 499.8 0.16 0.10% SA 200 1600 0.5 999.5 0.63 " ECOLI 100 1600 0.5 999.5 0.63 " PSA 1200 1600 0.5 999.5 0.63 " PC 1800 1250 0.5 999.5 0.80 " CAN 100 15000 0.5 999.5 0.07 " AN 100 3200 0.5 999.5 0.32 0.20% SA 200 1600 1 1999 1.25 " ECOLI 100 1600 1 1999 1.26 " PSA 1200 1600 1 1999 1.25 " PC 1800 1250 1 1999 1.60 " CAN 100 15000 1 1999 0.14 " AN 100 3200 1 1999 0.63 0.40% SA 200 1600 2 3998 2.51 " ECOLI 100 1600 2 3998 2.52 " PSA 1200 1600 2 3998 2.50 " PC 1800 1250 2 3998 3.20 " CAN 100 15000 2 3998 0.29 " AN 100 3200 2 3998 1.27 0.50% SA 200 1600 2.5 4997.5 3.14 " ECOLI 100 1600 2.5 4997.5 3.15 " PSA 1200 1600 2.5 4997.5 3.13 " PC 1800 1250 2.5 4997.5 4.00 " CAN 100 15000 2.5 4997.5 0.36 - AN 100 3200 2.5 4997.5 1.59 ______________________________________
TABLE 2 ______________________________________ 1000:1 Wt. Ratio GERMALL ® II/IPBC Use Level Organism Q.sub.a Q.sub.b Q.sub.A Q.sub.B SI ______________________________________ 0.01% SA 200 1600 0.1 99.9 0.06 " ECOLI 100 1600 0.1 99.9 0.06 " PSA 1200 1600 0.1 99.9 0.06 " PC 1800 1250 0.1 99.9 0.08 " CAN 100 15000 0.1 99.9 0.01 " AN 100 3200 0.1 99.9 0.03 0.025% SA 200 1600 0.25 249.8 0.16 " ECOLI 100 1600 0.25 249.8 0.16 " PSA 1200 1600 0.25 249.8 0.16 " PC 1800 1250 0.25 249.8 0.20 " CAN 100 15000 0.25 249.8 0.02 " AN 100 3200 0.25 249.8 0.08 0.05% SA 200 1600 0.5 499.5 0.31 " ECOLI 100 1600 0.5 499.5 0.32 " PSA 1200 1600 0.5 499.5 0.31 " PC 1800 1250 0.5 499.5 0.40 " CAN 100 15000 0.5 499.5 0.04 " AN 100 3200 0.5 499.5 0.16 0.10% SA 200 1600 1 999 0.63 " ECOLI 100 1600 1 999 0.63 " PSA 1200 1600 1 999 0.63 " PC 1800 1250 1 999 0.80 " CAN 100 15000 1 999 0.08 " AN 100 3200 1 999 0.32 0.20% SA 200 1600 2 1998 1.26 " ECOLI 100 1600 2 1998 1.27 " PSA 1200 1600 2 1998 1.25 " PC isoo 1250 2 1998 1.60 " CAN 100 15000 2 1998 0.15 " AN 100 3200 2 1998 0.64 0.40% SA 200 1600 4 3996 2.52 " ECOLI 100 1600 4 3996 2.54 " PSA 1200 1600 4 3996 2.50 " PC 1800 1250 4 3996 3.20 " CAN 100 15000 4 3996 0.31 " AN 100 3200 4 3996 1.29 0.50% SA 200 1600 5 4995 3.15 " ECOLI 100 1600 5 4995 3.17 " PSA 1200 1600 5 4995 3.13 " PC 1800 1250 5 4995 4.00 " CAN 100 15000 5 4995 0.38 " AN 100 3200 5 4995 1.61 ______________________________________
TABLE 3 ______________________________________ 500:1 Wt. Ratio GERMALL ® II/IPBC Use Level Organism Q.sub.a Q.sub.b Q.sub.A Q.sub.B SI ______________________________________ 0.01% SA 200 1600 0.2 99.8 0.06 " ECOLI 100 1600 0.2 99.8 0.06 " PSA 1200 1600 0.2 99.8 0.06 " PC 1800 1250 0.2 99.8 0.08 " CAN 100 15000 0.2 99.8 0.01 " AN 100 3200 0.2 99.8 0.03 0.025% SA 200 1600 0.5 249.5 0.16 " ECOLI 100 1600 0.5 249.5 0.16 " PSA 1200 1600 0.5 249.5 0.16 " PC 1800 1250 0.5 249.5 0.20 " CAN 100 15000 0.5 249.5 0.02 " AN 100 3200 0.5 249.5 0.08 0.05% SA 200 1600 1 499 0.32 " ECOLI 100 1600 1 499 0.32 " PSA 1200 1600 1 499 0.31 " PC 1800 1250 1 499 0.40 " CAN 100 15000 1 499 0.04 " AN 100 3200 1 499 0.17 0.10% SA 200 1600 2 998 0.63 " ECOLI 100 1600 2 998 0.64 " PSA 1200 1600 2 998 0.63 " PC 1800 1250 2 998 0.80 " CAN 100 15000 2 998 0.09 " AN 100 3200 2 998 0.33 0.20% SA 200 1600 4 1996 1.27 " ECOLI 100 1600 4 1996 1.29 " PSA 1200 1600 4 1996 1.25 " PC 1800 1250 4 1996 1.60 " CAN 100 15000 4 1996 0.17 " AN 100 3200 4 1996 0.66 0.40% SA 200 1600 8 3992 2.54 " ECOLI 100 1600 8 3992 2.58 " PSA 1200 1600 8 3992 2.50 " PC 1800 1250 8 3992 3.20 " CAN 100 15000 8 3992 0.35 " AN 100 3200 8 3992 1.33 0.50% SA 200 1600 10 4990 3.17 " ECOLI 100 1600 10 4990 3.22 " PSA 1200 1600 10 4990 3.13 " PC 1800 1250 10 4990 4.00 " CAN 100 15000 10 4990 0.43 " AN 100 3200 10 4990 1.66 ______________________________________
TABLE 4 ______________________________________ 200:1 Wt. Ratio GERMALL ® II/IPBC Use Level Organism Q.sub.a Q.sub.b Q.sub.A Q.sub.B SI ______________________________________ 0.01% SA 200 1600 0.5 99.5 0.06 " ECOLI 100 1600 0.5 99.5 0.07 " PSA 1200 1600 0.5 99.5 0.06 " PC 1800 1250 0.5 99.5 0.08 " CAN 100 15000 0.5 99.5 0.01 " AN 100 3200 0.5 99.5 0.04 0.025% SA 200 1600 1.25 248.75 0.16 " ECOLI 100 1600 1.25 248.75 0.17 " PSA 1200 1600 1.25 248.75 0.16 " PC 1800 1250 1.25 248.75 0.20 " CAN 100 15000 1.25 248.75 0.03 " AN 100 3200 1.25 248.75 0.09 0.05% SA 200 1600 2.5 497.5 0.32 " ECOLI 100 1600 2.5 497.5 0.34 " PSA 1200 1600 2.5 497.5 0.31 " PC 1800 1250 2.5 497.5 0.40 " CAN 100 15000 2.5 497.5 0.06 " AN 100 3200 2.5 497.5 0.18 0.10% SA 200 1600 5 995 0.65 " ECOLI 100 1600 5 995 0.67 " PSA 1200 1600 5 995 0.63 " PC 1800 1250 5 995 0.80 " CAN 100 15000 5 995 0.12 " AN 100 3200 5 995 0.36 0.20% SA 200 1600 10 1990 1.29 " ECOLI 100 1600 10 1990 1.34 " PSA 1200 1600 10 1990 1.25 " PC 1800 1250 10 1990 1.60 " CAN 100 15000 10 1990 0.23 " AN 100 3200 10 1990 0.72 0.40% SA 200 1600 20 3980 2.59 " ECOLI 100 1600 20 3980 2.69 " PSA 1200 1600 20 3980 2.50 " PC 1800 1250 20 3980 3.20 " CAN 100 15000 20 3980 0.47 " AN 100 3200 20 3980 1.44 0.50% SA 200 1600 25 4975 3.23 " ECOLI 100 1600 25 4975 3.36 " PSA 1200 1600 25 4975 3.13 " PC 1800 1250 25 4975 3.99 " CAN 100 15000 25 4975 0.58 " AN 100 3200 25 4975 1.80 ______________________________________
TABLE 5 ______________________________________ 100:1 Wt. Ratio GERMALL ® II/IPBC Use Level Organism Q.sub.a Q.sub.b Q.sub.A Q.sub.B SI ______________________________________ 0.01% SA 200 1600 1 99 0.06 " ECOLI 100 1600 1 99 0.07 " PSA 1200 1600 1 99 0.06 " PC 1800 1250 1 99 0.08 " CAN 100 15000 1 99 0.02 " AN 100 3200 1 99 0.04 0.025% SA 200 1600 2.5 248 0.17 " ECOLI 100 1600 2.5 248 0.18 " PSA 1200 1600 2.5 248 0.16 " PC 1800 1250 2.5 248 0.20 " CAN 100 15000 2.5 248 0.04 " AN 100 3200 2.5 248 0.10 0.05% SA 200 1600 5 495 0.33 " ECOLI 100 1600 5 495 0.36 " PSA 1200 1600 5 495 0.31 " PC 1800 1250 5 495 0.40 " CAN 100 15000 5 495 0.08 " AN 100 3200 5 495 0.20 0.10% SA 200 1600 10 990 0.67 " ECOLI 100 1600 10 990 0.72 " PSA 1200 1600 10 990 0.63 " PC 1800 1250 10 990 0.80 " CAN 100 15000 10 990 0.17 " AN 100 3200 10 990 0.41 0.20% SA 200 1600 20 1980 1.34 " ECOLI 100 1600 20 1980 1.44 " PSA 1200 1600 20 1980 1.25 " PC 1800 1250 20 1980 1.60 " CAN 100 15000 20 1980 0.33 " AN 100 3200 20 1980 0.82 0.40% SA 200 1600 40 3960 2.68 " ECOLI 100 1600 40 3960 2.88 " PSA 1200 1600 40 3960 2.51 " PC 1800 1250 40 3960 3.19 " CAN 100 15000 40 3960 0.66 " AN 100 3200 40 3960 1.64 0.50% SA 200 1600 50 4950 3.34 " ECOLI 100 1600 50 4950 3.59 " PSA 1200 1600 50 4950 3.14 " PC 1800 1250 50 4950 3.99 " CAN 100 15000 50 4950 0.83 " AN 100 3200 50 4950 2.05 ______________________________________
TABLE 6 ______________________________________ 50:1 Wt. Ratio GERMALL ® II/IPBC Use Level Organism Q.sub.a Q.sub.b Q.sub.A Q.sub.B SI ______________________________________ 0.01% SA 200 1600 2 98 0.07 0.01% ECOLI 100 1600 2 98 0.08 0.01% PSA 1200 1600 2 98 0.06 0.01% PC 1800 1250 2 98 0.08 0.01% CAN 100 15000 2 98 0.03 0.01% AN 100 3200 2 98 0.05 0.025% SA 200 1600 5 245 0.18 0.025% ECOLI 100 1600 5 245 0.20 0.025% PSA 1200 1600 5 245 0.16 0.025% PC 1800 1250 5 245 0.20 0.025% CAN 100 15000 5 245 0.07 0.025% AN 100 3200 5 245 0.13 0.05% SA 200 1600 10 490 0.36 0.05% ECOLI 100 1600 10 490 0.41 0.05% PSA 1200 1600 10 490 0.31 0.05% PC 1800 1250 10 490 0.40 0.05% CAN 100 15000 10 490 0.13 0.05% AN 100 3200 10 490 0.25 0.10% SA 200 1600 20 980 0.71 0.10% ECOLI 100 1600 20 980 0.81 0.10% PSA 1200 1600 20 980 0.63 0.10% PC 1800 1250 20 980 0.80 0.10% CAN 100 15000 20 980 0.27 0.10% AN 100 3200 20 980 0.51 0.20% SA 200 1600 40 1960 1.43 0.20% ECOLI 100 1600 40 1960 1.63 0.20% PSA 1200 1600 40 1960 1.26 0.20% PC 1800 1250 40 1960 1.59 0.20% CAN 100 15000 40 1960 0.53 0.20% AN 100 3200 40 1960 1.01 0.40% SA 200 1600 80 3920 2.85 0.40% ECOLI 100 1600 80 3920 3.25 0.40% PSA 1200 1600 80 3920 2.52 0.40% PC 1800 1250 80 3920 3.18 0.40% CAN 100 15000 80 3920 1.06 0.40% AN 100 3200 80 3920 2.03 0.50% SA 200 1600 100 4900 3.56 0.50% ECOLI 100 1600 100 4900 4.06 0.50% PSA 1200 1600 100 4900 3.15 0.50% PC 1800 1250 100 4990 3.98 0.50% CAN 100 15000 100 4900 1.33 0.50% AN 100 3200 100 4900 2.53 ______________________________________
TABLE 7 ______________________________________ 20:1 Wt. Ratio GERMALL ® II/IPBC Use Level Organism Q.sub.a Q.sub.b Q.sub.A Q.sub.B SI ______________________________________ 0.01% SA 200 1600 5 95 0.08 0.01% ECOLI 100 1600 5 95 0.11 0.01% PSA 1200 1600 5 95 0.06 0.01% PC 1800 1250 5 95 0.08 0.01% CAN 100 15000 5 95 0.06 0.01% AN 100 3200 5 95 0.08 0.025% SA 200 1600 12.5 237.5 0.21 0.025% ECOLI 100 1600 12.5 237.5 0.27 0.025% PSA 1200 1600 12.5 237.5 0.16 0.025% PC 1800 1250 12.5 237.5 0.20 0.025% CAN 100 15000 12.5 237.5 0.14 0.025% AN 100 3200 12.5 237.5 0.20 0.05% SA 200 1600 25 475 0.42 0.05% ECOLI 100 1600 25 475 0.55 0.05% PSA 1200 1600 25 475 0.32 0.05% PC 1800 1250 25 475 0.39 0.05% CAN 100 15000 25 475 0.28 0.05% AN 100 3200 25 475 0.40 0.10% SA 200 1600 50 950 0.84 0.10% ECOLI 100 1600 50 950 1.09 0.10% PSA 1200 1600 50 950 0.64 0.10% PC 1800 1250 50 950 0.79 0.10% CAN 100 15000 50 950 0.56 0.10% AN 100 3200 50 950 0.80 0.20% SA 200 1600 100 1900 1.69 0.20% ECOLI 100 1600 100 1900 2.19 0.20% PSA 1200 1600 100 1900 1.27 0.20% PC 1800 1250 100 1900 1.58 0.20% CAN 100 15000 100 1900 1.13 0.20% AN 100 3200 100 1900 1.59 0.40% SA 200 1600 200 4800 4.00 0.40% ECOLI 100 1600 200 4800 5.00 0.40% PSA 1200 1600 200 4800 3.17 0.40% PC 1800 1250 200 4800 3.95 0.40% CAN 100 15000 200 4800 2.32 0.40% AN 100 3200 200 4800 3.50 0.50% SA 200 1600 250 4750 4.22 0.50% ECOLI 100 1600 250 4750 5.47 0.50% PSA 1200 1600 250 4750 3.18 0.50% PC 1800 1250 250 4750 3.94 0.50% CAN 100 15000 250 4750 2.82 0.50% AN 100 3200 250 4750 3.98 ______________________________________
TABLE 8 ______________________________________ 2000:1 Wt. Ratio DMDMH/IPBC Use Level Organism Q.sub.a Q.sub.b Q.sub.A Q.sub.B SI ______________________________________ 0.01% SA 200 1600 0.05 99.95 0.06 0.01% ECOLI 100 800 0.05 99.95 0.13 0.01% PSA 1200 1600 0.05 99.95 0.06 0.01% PC 1800 1600 0.05 99.95 0.06 0.01% CAN 100 16000 0.05 99.95 0.01 0.01% AN 100 16000 0.05 99.95 0.01 0.025% SA 200 1600 0.125 249.88 0.16 0.025% ECOLI 100 800 0.125 249.88 0.31 0.025% PSA 1200 1600 0.125 249.88 0.16 0.025% PC 1800 1600 0.125 249.88 0.16 0.025% CAN 100 16000 0.125 249.88 0.02 0.025% AN 100 16000 0.125 249.88 0.02 0.05% SA 200 1600 0.25 499.75 0.31 0.05% ECOLI 100 800 0.25 499.75 0.63 0.05% PSA 1200 1600 0.25 499.75 0.31 0.05% PC 1800 1600 0.25 499.75 0.31 0.05% CAN 100 16000 0.25 499.75 0.03 0.05% AN 100 16000 0.25 499.75 0.03 0.10% SA 200 1600 0.5 999.5 0.63 0.10% ECOLI 100 800 0.5 999.5 1.25 0.10% PSA 1200 1600 0.5 999.5 0.63 0.10% PC 1800 1600 0.5 999.5 0.62 0.10% CAN 100 16000 0.5 999.5 0.07 0.10% AN 100 16000 0.5 999.5 0.07 0.20% SA 200 1600 1 1999 1.25 0.20% ECOLI 100 800 1 1999 2.51 0.20% PSA 1200 1600 1 1999 1.25 0.20% PC 1800 1600 1 1999 1.25 0.20% CAN 100 16000 1 1999 0.13 0.20% AN 100 16000 1 1999 0.13 0.40% SA 200 1600 2 3998 2.51 0.40% ECOLI 100 800 2 3998 5.02 0.40% PSA 1200 1600 2 3998 2.50 0.40% PC 1800 1600 2 3998 2.50 0.40% CAN 100 16000 2 3998 0.27 0.40% AN 100 16000 2 3998 0.27 0.50% SA 200 1600 2.5 4997.5 3.14 0.50% ECOLI 100 800 2.5 4997.5 6.27 0.50% PSA 1200 1600 2.5 4997.5 3.13 0.50% PC 1800 1600 2.5 4997.5 3.12 0.50% CAN 100 16000 2.5 4997.5 0.34 0.50% AN 100 16000 2.5 4997.5 0.34 ______________________________________
TABLE 9 ______________________________________ 1000:1 Wt. Ratio DMDMH/IPBC Use Level Organism Q.sub.a Q.sub.b Q.sub.A Q.sub.B SI ______________________________________ 0.01% SA 200 1600 0.1 99.9 0.06 0.01% ECOLI 100 800 0.1 99.9 0.13 0.01% PSA 1200 1600 0.1 99.9 0.06 0.01% PC 1800 1600 0.1 99.9 0.06 0.01% CAN 100 16000 0.1 99.9 0.01 0.01% AN 100 16000 0.1 99.9 0.01 0.025% SA 200 1600 0.25 249.8 0.16 0.025% ECOLI 100 800 0.25 249.8 0.31 0.025% PSA 1200 1600 0.25 249.8 0.16 0.025% PC 1800 1600 0.25 249.8 0.16 0.025% CAN 100 16000 0.25 249.8 0.02 0.025% AN 100 16000 0.25 249.8 0.02 0.05% SA 200 1600 0.5 499.5 0.31 0.05% ECOLI 100 800 0.5 499.5 0.63 0.05% PSA 1200 1600 0.5 499.5 0.31 0.05% PC 1800 1600 0.5 499.5 0.31 0.05% CAN 100 16000 0.5 499.5 0.04 0.05% AN 100 16000 0.5 499.5 0.04 0.10% SA 200 1600 1 999 0.63 0.10% ECOLI 100 800 1 999 1.26 0.10% PSA 1200 1600 1 999 0.63 0.10% PC 1800 1600 1 999 0.62 0.10% CAN 100 16000 1 999 0.07 0.10% AN 100 16000 1 999 0.07 0.20% SA 200 1600 2 1998 1.26 0.20% ECOLI 100 800 2 1998 2.52 0.20% PSA 1200 1600 2 1998 1.25 0.20% PC 1800 1600 2 1998 1.25 0.20% CAN 100 16000 2 1998 0.14 0.20% AN 100 16000 2 1998 0.14 0.40% SA 200 1600 4 3996 2.52 0.40% ECOLI 100 800 4 3996 5.04 0.40% PSA 1200 1600 4 3996 2.50 0.40% PC 1800 1600 4 3996 2.50 0.40% CAN 100 16000 4 3996 0.29 0.40% AN 100 16000 4 3996 0.29 0.50% SA 200 1600 5 4995 3.15 0.50% ECOLI 100 800 5 4995 6.29 0.50% PSA 1200 1600 5 4995 3.13 0.50% PC 1800 1600 5 4995 3.12 0.50% CAN 100 16000 5 4995 0.36 0.50% AN 100 16000 2.5 4997.5 0.36 ______________________________________
TABLE 10 ______________________________________ 500:1 Wt. Ratio DMDMH/IPBC Use Level Organism Q.sub.a Q.sub.b Q.sub.A Q.sub.B SI ______________________________________ 0.01% SA 200 1600 0.2 99.8 0.06 0.01% ECOLI 100 800 0.2 99.8 0.13 0.01% PSA 1200 1600 0.2 99.8 0.06 0.01% PC 1800 1600 0.2 99.8 0.06 0.01% CAN 100 16000 0.2 99.8 0.01 0.01% AN 100 16000 0.2 99.8 0.01 0.25% SA 200 1600 0.5 249.5 0.16 0.25% ECOLI 100 800 0.5 249.5 0.32 0.25% PSA 1200 1600 0.5 249.5 0.16 0.25% PC 1800 1600 0.5 249.5 0.16 0.25% CAN 100 16000 0.5 249.5 0.02 0.25% AN 100 16000 0.5 249.5 0.02 0.05% SA 200 1600 1 499 0.32 0.05% ECOLI 100 800 1 499 0.63 0.05% PSA 1200 1600 1 499 0.31 0.05% PC 1800 1600 1 499 0.31 0.05% CAN 100 16000 1 499 0.04 0.05% AN 100 16000 1 499 0.04 0.10% SA 200 1600 2 998 0.63 0.10% ECOLI 100 800 2 998 1.27 0.10% PSA 1200 1600 2 998 0.63 0.10% PC 1800 1600 2 998 0.62 0.10% CAN 100 16000 2 998 0.08 0.10% AN 100 16000 2 998 0.08 0.20% SA 200 1600 4 1996 1.27 0.20% ECOLI 100 800 4 1996 2.54 0.20% PSA 1200 1600 4 1996 1.25 0.20% PC 1800 1600 4 1996 1.25 0.20% CAN 100 16000 4 1996 0.16 0.20% AN 100 16000 4 1996 0.16 0.40% SA 200 1600 8 3992 2.54 0.40% ECOLI 100 800 8 3992 5.07 0.40% PSA 1200 1600 8 3992 2.50 0.40% PC 1800 1600 8 3992 2.50 0.40% CAN 100 16000 8 3992 0.33 0.40% AN 100 16000 8 3992 0.33 0.50% SA 200 1600 10 4900 3.11 0.50% ECOLI 100 800 10 4900 6.23 0.50% PSA 1200 1600 10 4900 3.07 0.50% PC 1800 1600 10 4900 3.07 0.50% CAN 100 16000 10 4900 0.41 0.50% AN 100 16000 10 4900 0.41 ______________________________________
TABLE 11 ______________________________________ 200:1 Wt. Ratio DMDMH/IPBC Use Level Organism Q.sub.a Q.sub.b Q.sub.A Q.sub.B SI ______________________________________ 0.01% SA 200 1600 0.5 99.5 0.06 0.01% ECOLI 100 800 0.5 99.5 0.13 0.01% PSA 1200 1600 0.5 99.5 0.06 0.01% PC 1800 1600 0.5 99.5 0.06 0.01% CAN 100 16000 0.5 99.5 0.01 0.01% AN 100 16000 0.5 99.5 0.01 0.025% SA 200 1600 1.25 248.75 0.16 0.025% ECOLI 100 800 1.25 248.75 0.32 0.025% PSA 1200 1600 1.25 248.75 0.16 0.025% PC 1800 1600 1.25 248.75 0.16 0.025% CAN 100 16000 1.25 248.75 0.03 0.025% AN 100 16000 1.25 248.75 0.03 0.05% SA 200 1600 2.5 497.5 0.32 0.05% ECOLI 100 800 2.5 497.5 0.65 0.05% PSA 1200 1600 2.5 497.5 0.31 0.05% PC 1800 1600 2.5 497.5 0.31 0.05% CAN 100 16000 2.5 497.5 0.06 0.05% AN 100 16000 2.5 497.5 0.06 0.10% SA 200 1600 5 995 0.65 0.10% ECOLI 100 800 5 995 1.29 0.10% PSA 1200 1600 5 995 0.63 0.10% PC 1800 1600 5 995 0.62 0.10% CAN 100 16000 5 995 0.11 0.10% AN 100 16000 5 995 0.11 0.20% SA 200 1600 10 1990 1.29 0.20% ECOLI 100 800 10 1990 2.59 0.20% PSA 1200 1600 10 1990 1.25 0.20% PC 1800 1600 10 1990 1.25 0.20% CAN 100 16000 10 1990 0.22 0.20% AN 100 16000 10 1990 0.22 0.40% SA 200 1600 20 3980 2.59 0.40% ECOLI 100 800 20 3980 5.18 0.40% PSA 1200 1600 20 3980 2.50 0.40% PC 1800 1600 20 3980 2.50 0.40% CAN 100 16000 20 3980 0.45 0.40% AN 100 16000 20 3980 0.45 0.50% SA 200 1600 25 4975 3.23 0.50% ECOLI 100 800 25 4975 6.47 0.50% PSA 1200 1600 25 4975 3.13 0.50% PC 1800 1600 25 4975 3.12 0.50% CAN 100 16000 25 4975 0.56 0.50% AN 100 16000 25 4975 0.56 ______________________________________
TABLE 12 ______________________________________ 100:1 Wt. Ratio DMDMH/IPBC Use Level Organism Q.sub.a Q.sub.b Q.sub.A Q.sub.B SI ______________________________________ 0.01% SA 200 1600 1 99 0.07 0.01% ECOLI 100 800 1 99 0.13 0.01% PSA 1200 1600 1 99 0.06 0.01% PC 1800 1600 1 99 0.06 0.01% CAN 100 16000 1 99 0.02 0.01% AN 100 16000 1 99 0.02 0.025% SA 200 1600 2.5 248 0.17 0.025% ECOLI 100 800 2.5 248 0.33 0.025% PSA 1200 1600 2.5 248 0.16 0.025% PC 1800 1600 2.5 248 0.16 0.025% CAN 100 16000 2.5 248 0.04 0.025% AN 100 16000 2.5 248 0.04 0.05% SA 200 1600 5 495 0.33 0.05% ECOLI 100 800 5 495 0.67 0.05% PSA 1200 1600 5 495 0.31 0.05% PC 1800 1600 5 495 0.31 0.05% CAN 100 16000 5 495 0.08 0.05% AN 100 16000 5 495 0.08 0.10% SA 200 1600 10 990 0.67 0.10% ECOLI 100 800 10 990 1.34 0.10% PSA 1200 1600 10 990 0.63 0.10% PC 1800 1600 10 990 0.62 0.10% CAN 100 16000 10 990 0.16 0.10% AN 100 16000 10 990 0.16 0.20% SA 200 1600 20 1980 1.34 0.20% ECOLI 100 800 20 1980 2.68 0.20% PSA 1200 1600 20 1980 1.25 0.20% PC 1800 1600 20 1980 1.25 0.20% CAN 100 16000 20 1980 0.32 0.20% AN 100 16000 20 1980 0.32 0.40% SA 200 1600 40 3960 2.68 0.40% ECOLI 100 800 40 3960 5.35 0.40% PSA 1200 1600 40 3960 2.51 0.40% PC 1800 1600 40 3960 2.50 0.40% CAN 100 16000 40 3960 0.65 0.40% AN 100 16000 40 3960 0.65 0.50% SA 200 1600 50 4950 3.34 0.50% ECOLI 100 800 50 4950 6.69 0.50% PSA 1200 1600 50 4950 3.14 0.50% PC 1800 1600 50 4950 3.12 0.50% CAN 100 16000 50 4950 0.81 0.50% AN 100 16000 50 4950 0.81 ______________________________________
TABLE 13 ______________________________________ 50:1 Wt. Ratio DMDMH/IPBC Use Level Organism Q.sub.a Q.sub.b Q.sub.A Q.sub.B SI ______________________________________ 0.01% SA 200 1600 2 98 0.07 0.01% ECOLI 100 800 2 98 0.14 0.01% PSA 1200 1600 2 98 0.06 0.01% PC 1800 1600 2 98 0.06 0.01% CAN 100 16000 2 98 0.03 0.01% AN 100 16000 2 98 0.03 0.025% SA 200 1600 5 245 0.18 0.025% ECOLI 100 800 5 245 0.36 0.025% PSA 1200 1600 5 245 0.16 0.025% PC 1800 1600 5 245 0.16 0.025% CAN 100 16000 5 245 0.07 0.025% AN 100 16000 5 245 0.07 0.05% SA 200 1600 10 490 0.36 0.05% ECOLI 100 800 10 490 0.71 0.05% PSA 1200 1600 10 490 0.31 0.05% PC 1800 1600 10 490 0.31 0.05% CAN 100 16000 10 490 0.13 0.05% AN 100 16000 10 490 0.13 0.10% SA 200 1600 20 980 0.71 0.10% ECOLI 100 800 20 980 1.43 0.10% PSA 1200 1600 20 980 0.63 0.10% PC 1800 1600 20 980 0.62 0.10% CAN 100 16000 20 980 0.26 0.10% AN 100 16000 20 980 0.26 0.20% SA 200 1600 40 1960 1.43 0.20% ECOLI 100 800 40 1960 2.85 0.20% PSA 1200 1600 40 1960 1.26 0.20% PC 1800 1600 40 1960 1.25 0.20% CAN 100 16000 40 1960 0.52 0.20% AN 100 16000 40 1960 0.52 0.40% SA 200 1600 80 3920 2.85 0.40% ECOLI 100 800 80 3920 5.70 0.40% PSA 1200 1600 80 3920 2.52 0.40% PC 1800 1600 80 3920 2.49 0.40% CAN 100 16000 80 3920 1.05 0.40% AN 100 16000 80 3920 1.05 0.50% SA 200 1600 100 4900 3.56 0.50% ECOLI 100 800 100 4900 7.13 0.50% PSA 1200 1600 100 4900 3.15 0.50% PC 1800 1600 100 4900 3.12 0.50% CAN 100 16000 100 4900 1.31 0.50% AN 100 16000 100 4900 1.31 ______________________________________
TABLE 14 ______________________________________ 20:1 Wt. Ratio DMDMH/IPBC Use Level Organism Q.sub.a Q.sub.b Q.sub.A Q.sub.B SI ______________________________________ 0.01% SA 200 1600 5 95 0.08 0.01% ECOLI 100 800 5 95 0.17 0.01% PSA 1200 1600 5 95 0.06 0.01% PC 1800 1600 5 95 0.06 0.01% CAN 100 16000 5 95 0.06 0.01% AN 100 16000 5 95 0.06 0.025% SA 200 1600 12.5 237.5 0.21 0.025% ECOLI 100 800 12.5 237.5 0.42 0.025% PSA 1200 1600 12.5 237.5 0.16 0.025% PC 1800 1600 12.5 237.5 0.16 0.025% CAN 100 16000 12.5 237.5 0.14 0.025% AN 100 16000 12.5 237.5 0.14 0.05% SA 200 1600 25 475 0.42 0.05% ECOLI 100 800 25 475 0.84 0.05% PSA 1200 1600 25 475 0.32 0.05% PC 1800 1600 25 475 0.31 0.05% CAN 100 16000 25 475 0.28 0.05% AN 100 16000 25 475 0.28 0.10% SA 200 1600 50 950 0.84 0.10% ECOLI 100 800 50 950 1.69 0.10% PSA 1200 1600 50 950 0.64 0.10% PC 1800 1600 50 950 0.62 0.10% CAN 100 16000 50 950 0.56 0.10% AN 100 16000 50 950 0.56 0.20% SA 200 1600 100 1900 1.69 0.20% ECOLI 100 800 100 1900 3.38 0.20% PSA 1200 1600 100 1900 1.27 0.20% PC 1800 1600 100 1900 1.24 0.20% CAN 100 16000 100 1900 1.12 0.20% AN 100 16000 100 1900 1.12 0.40% SA 200 1600 200 4800 4.00 0.40% ECOLI 100 800 200 4800 8.00 0.40% PSA 1200 1600 200 4800 3.17 0.40% PC 1800 1600 200 4800 3.11 0.40% CAN 100 16000 200 4800 2.30 0.40% AN 100 16000 200 4800 2.30 0.50% SA 200 1600 250 4750 4.22 0.50% ECOLI 100 800 250 4750 8.44 0.50% PSA 1200 1600 250 4750 3.18 0.50% PC 1800 1600 250 4750 3.11 0.50% CAN 100 16000 250 4750 2.80 0.50% AN 100 16000 250 4750 2.80 ______________________________________
______________________________________ % wt. ______________________________________ Phase A Stearic Acid 5.00 Mineral Oil 2.50 Cetyl Alcohol 1.00 Lareth-5 and Ceteth-5 and 0.50 Oleth-5 and Steareth-5 Glycerol Monostearate and 1.50 Polyoxyethylene Stearate Phase B Deionized Water 88.0 Triethanolamine 99% 1.00 Citric Acid 30% aqueous solution 0.60 Preservative Admixture qs ______________________________________
TABLE 15 __________________________________________________________________________ 2000:1 GERMALL ® II/IPBC __________________________________________________________________________ Test Level Organism 48 Hours 7 Days 14 Days 21 Days 28 Days __________________________________________________________________________ 0.01% AN 69,000 260,000 190,000 17,000 4,500 0.01% CAN 98,000 76,000 1,400 3,100 19,000 0.01% ECOLI 110,000 290,000 2,400 138,000 560,000 0.01% PC <10 <10 <10 <10 <10 0.01% PSA <10 <10 <10 <10 <10 0.01% SA 190,000 220 <10 <10 3,700 0.025% AN 2,800 10 10 <10 220 0.025% CAN 58,000 29,000 18,000 56,000 110,000 0.025% ECOLI 39,000 10 <10 <10 <10 0.025% PC <10 <10 <10 <10 <10 0.025% PSA <10 <10 <10 <10 <10 0.025% SA 37,000 170 <10 <10 <10 0.05% AN 20 <10 <10 <10 <10 0.05% CAN 19,000 6,600 70 <10 320 0.05% ECOLI 3,400 <10 <10 <10 <10 0.05% PC <10 <10 <10 <10 <10 0.05% PSA <10 <10 <10 <10 <10 0.05% SA 31,000 <10 <10 <10 <10 0.1% AN <10 <10 <10 <10 <10 0.1% CAN 180 <10 <10 <10 <10 0.1% ECOLI <10 <10 <10 <10 <10 0.1% PC <10 <10 <10 <10 <10 0.1% PSA <10 <10 <10 <10 <10 0.1% SA 750 <10 <10 <10 <10 0.2% AN <10 <10 <10 <10 <10 0.2% CAN <10 <10 <10 <10 <10 0.2% ECOLI <10 <10 <10 <10 <10 0.2% PC <10 <10 <10 <10 <10 0.2% PSA <10 <10 <10 <10 <10 0.2% SA <10 <10 <10 <10 <10 Unpreserved control AN 52,000 27,000 19,000 19,000 19,000 CAN 110,000 130,000 240,000 180,000 240,000 ECOLI 54,000 140,000 170,000 170,000 74,000 PC 6,400,000 6,400,000 2,000,000 6,700,000 29,000 PSA 110,000 700 110,000 290,000 85,000 SA 2,800,000 250,000 51,000 3,700 330 Inoculum Concentration 0 Hours 21 Days AN 26,000 53,000 CAN 1,000,000 1,900,000 ECOLI 3,600,000 170,000 PC 3,400,000 87,000 PSA 4,500,000 390,000 SA 4,100,000 200,000 __________________________________________________________________________
TABLE 16 __________________________________________________________________________ 1000:1 GERMALL ® II/IPBC __________________________________________________________________________ Test Level Organism 48 Hours 7 Days 14 Days 21 Days 28 Days __________________________________________________________________________ 0.01% AN 34,000 3,500 80 10 <10 0.01% CAN 420,000 24,000 950 6,400 6,400,000 0.01% ECOLI 120,000 63,000 93,000 92,000 9,600,000 0.01% PC 10 25,000 1,600 15,800 33,000,000 0.01% PSA <10 <10 <10 <10 <10 0.01% SA 100,000 1,400 <10 <10 5,000 0.025% AN 530 10 <10 <10 <10 0.025% CAN 34,000 750 10 770 240,000 0.025% ECOLI 120,000 <10 <10 <10 <10 0.025% PC <10 <10 <10 <10 <10 0.025% PSA <10 <10 <10 <10 <10 0.025% SA 37,000 170 <10 <10 <10 0.05% AN <10 <10 <10 <10 <10 0.05% CAN 13,000 <10 <10 <10 <10 0.05% ECOLI 68,000 <10 <10 <10 <10 0.05% PC <10 <10 <10 <10 <10 0.05% PSA <10 < 10 <10 <10 <10 0.05% SA 21,000 <10 <10 <10 <10 0.1% AN <10 <10 <10 <10 <10 0.1% CAN 10 <10 <10 <10 <10 0.1% ECOLI <10 <10 <10 <10 <10 0.1% PC <10 <10 <10 <10 <10 0.1% PSA <10 <10 <10 <10 <10 0.1% SA 1,400 <10 <10 <10 <10 0.2% AN <10 <10 <10 <10 <10 0.2% CAN <10 <10 <10 <10 <10 0.2% ECOLI <10 <10 <10 <10 <10 0.2% PC <10 <10 <10 <10 <10 0.2% PSA <10 <10 <10 <10 <10 0.2% SA <10 <10 <10 <10 <10 Unpreserved control AN 52,000 27,000 19,000 19,000 19,000 CAN 110,000 130,000 240,000 180,000 240,000 ECOLI 54,000 140,000 170,000 170,000 74,000 PC 6,400,000 6,400,000 2,000,000 6,700,000 29,000 PSA 110,000 700 110,000 290,000 85,000 SA 2,800,000 250,000 51,000 3,700 330 Inoculum Concentration 0 Hours 21 Days AN 26,000 53,000 CAN 1,000,000 1,900,000 ECOLI 3,600,000 170,000 PC 3,400,000 87,000 PSA 4,500,000 390,000 SA 4,100,000 200,000 __________________________________________________________________________
TABLE 17 __________________________________________________________________________ 500:1 GERMALL ® II/IPBC __________________________________________________________________________ Test Level Organism 48 Hours 7 Days 14 Days 21 Days 28 Days __________________________________________________________________________ 0.01% AN 23,000 40 <10 <10 <10 0.01% CAN 170,000 5,600 290 200 <10 0.01% ECOLI 90,000 57,000 95,000 70,000 240,000 0.01% PC 10 <10 <10 >10,000 42,000,000 0.01% PSA <10 <10 <10 <10 <10 0.01% SA 380,000 440 <10 <10 5,100 0.05% AN <10 <10 <10 <10 <10 0.05% CAN 8,700 <10 <10 <10 <10 0.05% ECOLI 60,000 <10 <10 <10 <10 0.05% PC <10 <10 <10 <10 <10 0.05% PSA <10 <10 <10 <10 <10 0.05% SA 31,000 <10 <10 <10 <10 0.1% AN <10 <10 <10 <10 <10 0.1% CAN <10 <10 <10 <10 <10 0.1% ECOLI <10 <10 <10 <10 <10 0.1% PC <10 <10 <10 <10 <10 0.1% PSA <10 <10 <10 <10 <10 0.1% SA 890 <10 <10 <10 <10 0.2% AN <10 <10 <10 <10 <10 0.2% CAN <10 <10 <10 <10 <10 0.2% ECOLI <10 <10 <10 <10 <10 0.2% PC <10 <10 <10 <10 <10 0.2% PSA <10 <10 <10 <10 <10 0.2% SA <10 <10 <10 <10 <10 Unpreserved control AN 6,100 520,000 18,000 5,000 11,000 CAN 1,000,000 710,000 95,000 12,000 64,000 ECOLI 7,100,000 6,200,000 610,000 350,000 120,000 PC 14,600,000 160,000,000 3,600,000 2,720,000 9,500,000 PSA 20 900 130 4,100 >100,000 SA 43,000,000 600,000 1,000 220 <10 Inoculum Concentration 0 Hours 21 Days AN 19,000 4,700,000 CAN 340,000 16,000,000 ECOLI 3,900,000 1,480,000 PC 3,800,000 1,380,000 PSA 9,200,000 730,000 SA 4,800,000 360,000 __________________________________________________________________________
TABLE 18 __________________________________________________________________________ 200:1 GERMALL ® II/IPBC __________________________________________________________________________ Test Level Organism 48 Hours 7 Days 14 Days 21 Days 28 Days __________________________________________________________________________ 0.01% AN 47,000 320 10 <10 <10 0.01% CAN 810,000 450,000 410,000 190,000 63,000 0.01% ECOLI 220,000 7,600 <10 850 >1,000,000 0.01% PC 10,000 500,000 1,900,000 1,100,000 193,000 0.01% PSA <10 <10 <10 <10 <10 0.01% SA 190,000 23,000 120 <10 <10 0.05% AN <10 <10 <10 <10 <10 0.05% CAN 190 <10 <10 <10 <10 0.05% ECOLI 37,000 <10 <10 <10 <10 0.05% PC <10 <10 <10 <10 <10 0.05% PSA <10 <10 <10 <10 <10 0.05% SA 19,000 <10 <10 <10 <10 0.1% AN <10 <10 <10 <10 <10 0.1% CAN 10 <10 <10 <10 <10 0.1% ECOLI <10 <10 <10 < 10 <10 0.1% PC <10 <10 <10 <10 <10 0.1% PSA <10 <10 <10 <10 <10 0.1% SA 45,000 <10 <10 <10 <10 0.2% AN <10 <10 <10 <10 <10 0.2% CAN <10 <10 <10 <10 <10 0.2% ECOLI <10 <10 <10 <10 <10 0.2% PC <10 <10 <10 <10 <10 0.2% PSA <10 <10 <10 <10 <10 0.2% SA <10 <10 <10 <10 <10 Unpreserved control AN 89,000 32,000 22,000 16,000 16,000 CAN 210,000 670,000 430,000 590,000 640,000 ECOLI 640,000 360,000 410,000 990,000 68,000 PC 19,000,000 3,200,000 7,000,000 >10,000 2,760,000 PSA 80 9,400 200,000 >10,000 34,000 SA 6,300,000 190,000 11,000 580 120 Inoculum Concentration 0 Hours 21 Days AN 41,000 32,000 CAN 640 1,100,000 ECOLI 5,800,000 1,300,000 PC 900,000 3,000,000 PSA 1,800,000 4,900,000 SA 7,200,000 2,000,000 __________________________________________________________________________
TABLE 19 __________________________________________________________________________ 50:1 GERMALL ® II/IPBC __________________________________________________________________________ Test Level Organism 48 Hours 7 Days 14 Days 21 Days 28 Days __________________________________________________________________________ 0.01% AN 4,100 40 <10 <10 <10 0.01% CAN 310,000 7,700 560 5,600 5,200 0.01% ECOLI 170,000 710 10 <10 120 0.01% PC 7,400 74,000 340,000 720,000 520,000 0.01% PSA <10 <10 <10 <10 30 0.01% SA 110,000 11,000 <10 <10 9,200 0.05% AN <10 100 <10 <10 <10 0.05% CAN 210 <10 <10 <10 <10 0.05% ECOLI 150,000 <10 <10 <10 <10 0.05% PC <10 <10 <10 <10 <10 0.05% PSA <10 <10 <10 <10 <10 0.05% SA 35,000 <10 <10 <10 <10 0.1% AN <10 <10 <10 <10 <10 0.1% CAN <10 <10 <10 <10 <10 0.1% ECOLI 510 <10 <10 <10 <10 0.1% PC <10 <10 <10 <10 <10 0.1% PSA <10 <10 <10 <10 <10 0.1% SA 3,000 <10 <10 <10 <10 0.2% AN <10 <10 <10 <10 <10 0.2% CAN <10 <10 <10 <10 <10 0.2% ECOLI <10 <10 <10 <10 <10 0.2% PC <10 <10 <10 <10 <10 0.2% PSA <10 <10 <10 <10 <10 0.2% SA <10 <10 <10 <10 <10 Unpreserved control AN 89,000 32,000 22,000 16,000 16,000 CAN 210,000 670,000 430,000 590,000 640,000 ECOLI 640,000 360,000 410,000 990,000 68,000 PC 19,000,000 3,200,000 7,000,000 >10,000 2,760,000 PSA 80 9,400 200,000 >10,000 34,000 SA 6,300,000 190,000 11,000 580 120 Inoculum Concentration 0 Hours 21 Days AN 41,000 32,000 CAN 640 1,100,000 ECOLI 5,800,000 1,300,000 PC 900,000 3,000,000 PSA 1,800,000 4,900,000 SA 7,200,000 2,000,000 __________________________________________________________________________
TABLE 20 __________________________________________________________________________ 20:1 GERMALL ® II/IPBC __________________________________________________________________________ Test Level Organism 48 Hours 7 Days 14 Days 21 Days 28 Days __________________________________________________________________________ 0.01% AN 3,100 <10 <10 <10 <10 0.01% CAN 75,000 220 <10 <10 2,400 0.01% ECOLI 160,000 110 <10 <10 20 0.01% PC 12,000 1,000,000 2,100,000 >1,000,000 730,000 0.01% PSA <10 <10 <10 <10 4,000 0.01% SA 140,000 4,100 <10 <10 1,680 0.05% AN <10 <10 <10 <10 <10 0.05% CAN <10 <10 <10 <10 <10 0.05% ECOLI 16,000 <10 <10 <10 <10 0.05% PC <10 <10 <10 <10 <10 0.05% PSA <10 <10 <10 <10 0.05% SA 31,000 <10 <10 <10 <10 0.1% AN <10 <10 <10 <10 <10 0.1% CAN <10 <10 <10 <10 <10 0.1% ECOLI <10 <10 <10 <10 <10 0.1% PC < 10 <10 <10 <10 <10 0.1% PSA <10 <10 <10 <10 <10 0.1% SA 6,800 <10 <10 <10 <10 0.2% AN <10 <10 <10 <10 <10 0.2% CAN <10 <10 <10 <10 <10 0.2% ECOLI <10 <10 <10 <10 <10 0.2% PC <10 <10 <10 <10 <10 0.2% PSA <10 <10 <10 <10 <10 0.2% SA <10 <10 <10 <10 <10 Unpreserved control AN 89,000 32,000 22,000 16,000 16,000 CAN 210,000 670,000 430,000 590,000 640,000 ECOLI 640,000 360,000 410,000 990,000 68,000 PC 19,000,000 3,200,000 7,000,000 >10,000 2,760,000 PSA 80 9,400 200,000 >10,000 34,000 SA 6,300,000 190,000 11,000 580 120 Inoculum Concentration 0 Hours 21 Days AN 41,000 32,000 CAN 640 1,100,000 ECOLI 5,800,000 1,300,000 PC 900,000 3,000,000 PSA 1,800,000 4,900,000 SA 7,200,000 2,000,000 __________________________________________________________________________
TABLE 21 __________________________________________________________________________ 2000:1 DMDMH/IPBC __________________________________________________________________________ Test Level Organism 48 Hours 7 Days 14 Days 21 Days 28 Days __________________________________________________________________________ 0.025% AN 4,100 38,000 270 80 100 0.025% CAN 270,000 1,900,000 550,000 220,000 210,000 0.025% ECOLI 1,300,000 <10 <10 <10 3,000 0.025% PC <10 <10 <10 <10 <10 0.025% PSA <10 <10 <10 <10 <10 0.025% SA 42,000 20 <10 <10 <10 0.05% AN <10 <10 <10 <10 <10 0.05% CAN 770,000 130,000 670,000 160,000 64,000 0.05% ECOLI 220,000 <10 <10 <10 <10 0.05% PC <10 <10 <10 <10 <10 0.05% PSA <10 <10 <10 <10 <10 0.05% SA 9,000 <10 <10 <10 <10 0.1% AN <10 <10 <10 <10 <10 0.1% CAN 580 840 500 40,000 83,000 0.1% ECOLI 340 <10 <10 <10 <10 0.1% PC <10 <10 <10 < 10 <10 0.1% PSA <10 <10 <10 <10 <10 0.1% SA 29,000 <10 <10 <10 <10 0.2% AN <10 <10 <10 <10 <10 0.2% CAN <10 10 10 <10 21 0.2% ECOLI <10 <10 <10 <10 <10 0.2% PC <10 <10 <10 <10 <10 0.2% PSA <10 <10 <10 <10 <10 0.2% SA <10 <10 <10 <10 <10 Unpreserved control AN 37,000 36,000 24,000 5,200 6,000 CAN 120,000 1,900,000 3,300,000 480,000 790,000 ECOLI 150,000 2,500,000 7,300,000 240,000 140,000 PC 19,000,000 15,600,000 5,900,000 8,500,000 31,000,000 PSA <10 <10 100 15,200 300,000 SA 7,000,000 >1,000,000 12,000 3,000 110 Inoculum Concentration 0 Hours 21 Days AN 50,000 41,000 CAN 1,400,000 640 ECOLI 4,800,000 5,800,000 PC 9,200,000 900,000 PSA 6,900,000 9,000,000 SA 5,700,000 7,200,000 __________________________________________________________________________
TABLE 22 __________________________________________________________________________ 1000:1 DMDMH/IPBC __________________________________________________________________________ Test Level Organism 48 Hours 7 Days 14 Days 21 Days 28 Days __________________________________________________________________________ 0.025% AN 650 900 <10 <10 140 0.025% CAN 97,000 900,000 2,300,000 120,000 120,000 0.025% ECOLI 160,000 <10 <10 <10 2,400 0.025% PC <10 <10 <10 <10 <10 0.025% PSA <10 <10 <10 <10 <10 0.025% SA 23,000 <10 <10 <10 90 0.05% AN 20 <10 <10 <10 <10 0.05% CAN 65,000 520,000 56,000 32,000 370,000 0.05% ECOLI 26,000 <10 <10 <10 <10 0.05% PC <10 <10 <10 <10 <10 0.05% PSA <10 <10 <10 <10 <10 0.05% SA 12,000 <10 <10 <10 <10 0.1% AN <10 <10 <10 <10 <10 0.1% CAN 3,100 4,800 180 640 4,400 0.1% ECOLI 45,000 <10 <10 < 10 <10 0.1% PC <10 <10 <10 <10 <10 0.1% PSA <10 <10 <10 <10 <10 0.1% SA 6,000 <10 <10 <10 <10 0.2% AN <10 <10 <10 <10 <10 0.2% CAN <10 <10 <10 <10 <10 0.2% ECOLI <10 <10 <10 <10 <10 0.2% PC <10 <10 <10 <10 <10 0.2% PSA <10 <10 <10 <10 <10 0.2% SA 180 <10 <10 <10 <10 Unpreserved control AN 37,000 36,000 24,000 5,200 6,000 CAN 120,000 1,900,000 3,300,000 480,000 790,000 ECOLI 150,000 2,500,000 7,300,000 240,000 140,000 PC 19,000,000 15,600,000 5,900,000 8,500,000 31,000,000 PSA <10 <10 100 15,200 300,000 SA 7,000,000 >1,000,000 12,000 3,000 110 Inoculum Concentration 0 Hours 21 Days AN 50,000 41,000 CAN 1,400,000 640 ECOLI 4,800,000 5,800,000 PC 9,200,000 900,000 PSA 6,900,000 9,000,000 SA 5,700,000 7,200,000 __________________________________________________________________________
TABLE 23 __________________________________________________________________________ 2000:1 GADM/IPBC __________________________________________________________________________ Test Level Organism 48 Hours 7 Days 14 Days 21 Days 28 Days __________________________________________________________________________ 0.025% AN 300 21 10 <10 11 0.025% CAN 480,000 890,000 940,000 1,040,000 130,000 0.025% ECOLI 230,000 <10 <10 <10 <10 0.025% PC <10 <10 <10 <10 <10 0.025% PSA <10 <10 <10 <10 <10 0.025% SA 78,000 <10 <10 <10 <10 0.05% AN <10 <10 <10 <10 <10 0.05% CAN 110,000 4,100,000 3,600,000 330,000 97,000 0.05% ECOLI 120,000 <10 <10 <10 <10 0.05% PC <10 <10 <10 <10 <10 0.05% PSA <10 <10 <10 <10 <10 0.05% SA 56,000 <10 <10 <10 <10 0.1% AN <10 <10 <10 <10 <10 0.1% CAN 1,200,000 53,000 430,000 144,000 110,000 0.1% ECOLI <10 <10 <10 <10 <10 0.1% PC <10 < 10 <10 <10 <10 0.1% PSA <10 <10 <10 <10 <10 0.1% SA <10 <10 <10 <10 <10 0.2% AN <10 <10 <10 <10 <10 0.2% CAN 90,000 <10 <10 <10 60 0.2% ECOLI <10 <10 <10 <10 <10 0.2% PC <10 <10 <10 <10 <10 0.2% PSA <10 <10 <10 <10 <10 0.2% SA <10 <10 <10 <10 <10 Unpreserved control AN 50,000 33,000 33,000 13,000 5,400 CAN 780,000 780,000 780,000 500,000 170,000 ECOLI 600,000 3,100,000 920,000 920,000 140,000 PC 11,000,000 30,000,000 10,000,000 10,000,000 1,400,000 PSA 3,800 600 12,800 12,800 100,000 SA 14,000,000 410,000 7,100 7,100 80 Inoculum Concentration 0 Hours 21 Days AN 53,000 10,000 CAN 1,900,000 310,000 ECOLI 170,000 3,500,000 PC 87,000 2,500,000 PSA 390,000 5,400,000 SA 200,000 4,100,000 __________________________________________________________________________
Claims (7)
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
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US08/234,089 US5428050A (en) | 1994-04-28 | 1994-04-28 | Synergistic water soluble preservative compositions of biocidal mixtures |
US08/392,635 US5496842A (en) | 1994-04-28 | 1995-02-22 | Synergistic water soluble preservative compositions of biocidal mixtures |
US08/413,742 US5552425A (en) | 1994-04-28 | 1995-03-30 | Synergistic water soluble preservative compositions of biocidal mixtures |
PCT/US1995/004895 WO1995029588A1 (en) | 1994-04-28 | 1995-04-21 | Synergistic water soluble preservative compositions of biocidal mixtures |
KR1019960705002A KR100377974B1 (en) | 1994-04-28 | 1995-04-21 | Synergistic Water Soluble Preservative Composition of Sterilization Mixture |
EP95917099A EP0757518B1 (en) | 1994-04-28 | 1995-04-21 | Synergistic water soluble preservative compositions of biocidal mixtures |
ES95917099T ES2158106T3 (en) | 1994-04-28 | 1995-04-21 | CONSERVATIVE SYNERGIC HYDRO-SOLVABLE COMPOSITIONS OF BIOCIDES BLENDS. |
CA002183652A CA2183652C (en) | 1994-04-28 | 1995-04-21 | Synergistic water soluble preservative compositions of biocidal mixtures |
NZ284708A NZ284708A (en) | 1994-04-28 | 1995-04-21 | Synergistic biocidal preservative compositions comprising metholyl compounds and 3-iodo-2-propynylbutyl carbamate |
DE69521128T DE69521128T2 (en) | 1994-04-28 | 1995-04-21 | SYNERGISTIC, WATER-SOLUBLE PRESERVATIVE COMPOSITIONS OF BIOCIDAL MIXTURES |
AU23923/95A AU691613B2 (en) | 1994-04-28 | 1995-04-21 | Synergistic water soluble preservative compositions of biocidal mixtures |
HU9602963A HU228148B1 (en) | 1994-04-28 | 1995-04-21 | Synergetic water soluble preservative compositions of biocidal mixtures |
PL95316963A PL181504B1 (en) | 1994-04-28 | 1995-04-21 | Water-soluble synergistic protective compositions of lethal compounds |
US08/652,190 US5631273A (en) | 1994-04-28 | 1996-05-23 | Synergistic water soluble preservative compositions of biocidal mixtures |
Applications Claiming Priority (1)
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US08/234,089 US5428050A (en) | 1994-04-28 | 1994-04-28 | Synergistic water soluble preservative compositions of biocidal mixtures |
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US08/392,635 Division US5496842A (en) | 1994-04-28 | 1995-02-22 | Synergistic water soluble preservative compositions of biocidal mixtures |
US08/413,742 Continuation-In-Part US5552425A (en) | 1994-04-28 | 1995-03-30 | Synergistic water soluble preservative compositions of biocidal mixtures |
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US5428050A true US5428050A (en) | 1995-06-27 |
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US08/234,089 Expired - Lifetime US5428050A (en) | 1994-04-28 | 1994-04-28 | Synergistic water soluble preservative compositions of biocidal mixtures |
US08/392,635 Expired - Lifetime US5496842A (en) | 1994-04-28 | 1995-02-22 | Synergistic water soluble preservative compositions of biocidal mixtures |
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US08/392,635 Expired - Lifetime US5496842A (en) | 1994-04-28 | 1995-02-22 | Synergistic water soluble preservative compositions of biocidal mixtures |
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Cited By (17)
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US5593681A (en) * | 1991-05-01 | 1997-01-14 | Isp Chemicals Inc. | Glycine anhydride dimethylol as a biocide and preservative |
US5827522A (en) * | 1996-10-30 | 1998-10-27 | Troy Corporation | Microemulsion and method |
WO1998052416A1 (en) * | 1997-05-23 | 1998-11-26 | Air Liquide Sante (International) | Preservative compositions based on iodopropynl- and formaldehyde donor compounds |
US5965594A (en) * | 1998-03-30 | 1999-10-12 | Mcintyre Group, Ltd. | Antimicrobial liquid preservative solutions and process for preparation |
US6143204A (en) * | 1998-06-19 | 2000-11-07 | Lonza Inc. | Stabilization of iodopropynl compounds |
US6432433B1 (en) | 2000-06-05 | 2002-08-13 | Isp Investments Inc. | Liquid biocidal composition of a formaldehyde adduct and an isothiazolone and method of use |
US20030039580A1 (en) * | 2001-02-26 | 2003-02-27 | Lonza Inc. | Stable preservative formulations comprising halopropynyl compounds and butoxydiglycol solvent |
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US20050214376A1 (en) * | 2003-10-21 | 2005-09-29 | Marie-Pierre Faure | Hydrogel-containing medical articles and methods of using and making the same |
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US20060058210A1 (en) * | 2004-09-15 | 2006-03-16 | The Procter & Gamble Company | Wet wipe lotions comprising particulate material |
US20060195357A1 (en) * | 2005-02-25 | 2006-08-31 | Klofta Thomas J | Providing and communicating synergies between absorbent articles and disposable wipes |
JP2014528954A (en) * | 2011-09-29 | 2014-10-30 | エシコン・インコーポレイテッドEthicon, Inc. | Broad-spectrum antibacterial composition based on a combination of taurolidine and protamine and medical devices containing such a composition |
EP2687096A1 (en) * | 2012-07-19 | 2014-01-22 | Straetmans high TAC GmbH | Micro-biocidal composition and use of same in the conservation of technical products |
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