US5344452A - Alloplastic implant - Google Patents
Alloplastic implant Download PDFInfo
- Publication number
- US5344452A US5344452A US07/572,975 US57297590A US5344452A US 5344452 A US5344452 A US 5344452A US 57297590 A US57297590 A US 57297590A US 5344452 A US5344452 A US 5344452A
- Authority
- US
- United States
- Prior art keywords
- particles
- solid
- solid particles
- implant
- implant according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime, expires
Links
- 239000007943 implant Substances 0.000 title claims abstract description 31
- 239000002245 particle Substances 0.000 claims abstract description 53
- 239000007787 solid Substances 0.000 claims abstract description 41
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims abstract description 6
- 239000004926 polymethyl methacrylate Substances 0.000 claims abstract description 6
- 239000000843 powder Substances 0.000 claims abstract description 6
- 239000011324 bead Substances 0.000 claims description 23
- 239000000375 suspending agent Substances 0.000 claims description 23
- 229920000642 polymer Polymers 0.000 claims description 13
- 210000001519 tissue Anatomy 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 235000019441 ethanol Nutrition 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000001828 Gelatine Substances 0.000 claims description 5
- 229920000159 gelatin Polymers 0.000 claims description 5
- 235000019322 gelatine Nutrition 0.000 claims description 5
- 210000002751 lymph Anatomy 0.000 claims description 5
- 229920000193 polymethacrylate Polymers 0.000 claims description 2
- 238000002513 implantation Methods 0.000 claims 2
- 125000005909 ethyl alcohol group Chemical group 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 abstract description 27
- 239000007924 injection Substances 0.000 abstract description 27
- 239000008188 pellet Substances 0.000 abstract description 3
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- 239000004033 plastic Substances 0.000 abstract description 2
- 229920003023 plastic Polymers 0.000 abstract description 2
- -1 poly(methyl methacrylate) Polymers 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 10
- 238000012360 testing method Methods 0.000 description 6
- 102000008186 Collagen Human genes 0.000 description 5
- 108010035532 Collagen Proteins 0.000 description 5
- 229920001436 collagen Polymers 0.000 description 5
- 210000002808 connective tissue Anatomy 0.000 description 4
- 238000002316 cosmetic surgery Methods 0.000 description 4
- 230000004069 differentiation Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 4
- 229920000136 polysorbate Polymers 0.000 description 4
- 229920000053 polysorbate 80 Polymers 0.000 description 4
- 229920002545 silicone oil Polymers 0.000 description 4
- 230000007704 transition Effects 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000001616 monocyte Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000000630 fibrocyte Anatomy 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000011882 arthroplasty Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002951 depilatory effect Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000003176 fibrotic effect Effects 0.000 description 1
- 230000009791 fibrotic reaction Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229940105631 nembutal Drugs 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003356 suture material Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0059—Cosmetic or alloplastic implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
Definitions
- the invention relates to an alloplastic implant on the basis of a histocompatible solid.
- the implant is particularly used in to even out skin irregularities. It can, however, be used for any other purpose in plastic surgery.
- Collagen is a xenogeneic protein product which is degraded in the body.
- collagen is a xenogeneic protein product which is degraded in the body.
- an irregularity of the skin has been evened out with collagen, for instance by an injection under the skin (intracutanously or subcutaneously) then it is normally necessary to have further injections in order to restore the results originally obtained after the first injection.
- collagen causes allergies so that allergic reactions can be observed in at least 3% of the cases.
- the likelihood of allergic reaction increases with multiple injections which is normally required to obtain the desired result.
- gelatine It is furthermore known to use gelatine for the above given purpose.
- gelatine has similar drawbacks as collagen.
- it is much more difficult to inject gelatine.
- silicone or silicone oils have been used.
- silicone oils cause a severe reaction of the tissue at the site of the injection (siliconome).
- silicone oils are rather badly kept in place by the tissue at the injection site so that, as a consequence, the silicone oils are transmitted to more or less distant parts of the body, for instance lymphatic nodules and liver.
- a histocompatible solid in the form of a powder is used as an implant.
- the solid particles forming the solid which may be incorporated into a suspending agent, are injected for instance with an injection needle at the desired site.
- the solid particles used according to the present invention have a smooth surface and are free from corners, edges and so on.
- the particles are not allowed to have sharp transitions at their surface. Said transitions are for instance found at such corners and edges.
- they are not allowed to have peaks of any kind or tapered projections.
- the surface should not have pores.
- dynamically balanced solid particles and in particular particles having an elliptic or spherical form are used.
- solid particles of a different geometrical form if all the particles have a smooth and smoothed off surface.
- the solid particles preferably have an average diameter of about 15 to about 200 ⁇ m and more preferred from about 15 to about 60 ⁇ m.
- the solid particles are also small enough to be injected through a cannula of an injection syringe to the desired site.
- Particles having the diameters specified above can also not be identified by touch as a single foreign body in or under the skin.
- the solid particles preferably have such a diameter that they are not washed away through lymph tracts or other tissue tracts from the site to which they have been brought.
- the diameter as used in the present documents refers to the greatest diameter of the smallest cross sectional area.
- the particles having a spherical form or a spherical like form have the advantage that they form a closely packed arrangement at the site where they have been brought.
- the solid particles used according to the present invention consist of an inert, histocompatible material.
- Such material can, for instance, be glass which is present in the form of glass beads or glass pellets having a smooth and smoothed off surface.
- the solid particles used according to the present invention consist preferably of a polymer and in particular of a completely cured and fully polymerised polymer so that no remaining monomers, which may be toxic or may cause cancer, are incorporated into the body of the treated patient.
- polymethacrylates and in particular polymethylmethacrylate (PMMA) are used as polymers.
- Fully polymerised PMMA is histocompatible and can be incorporated in the human body without fear so that it can be considered as chemically and physically inert.
- said polymer has already been used for manufacturing implants, for instance for the plastic covering of bone defects in the face and in the cranium or as an arthroplasty. Said polymer is also being used for manufacturing artificial teeth, as suture material and for manufacturing intraocular lenses and dialysis membranes.
- said particles are preferably suspended in a kind of suspending agent.
- suspending agent for instance, water, alcohols, in particular ethyl alcohol, as well as mixtures thereof can be used as suspending agents.
- the suspending agents used according to the present invention perferably contain a tenside, for instance Tween 80, since such a tenside changes the surface tension of water so that the solid particles and in particular the polymer particles float better.
- a tenside for instance Tween 80
- the mixing ratio of the components of the suspending agent can be chosen according to the needs and in particular according to the size of the syringe used for the injection.
- a suitable mixture consists of 0.5 ml ethylalcohol, 0.5 ml Tween 80 and 9 ml water.
- Tween is a trademark of ICI Americas Inc. Under this nomination polyoxyethylenderivatives of sorbitanesters are distributed.
- Tween 80 is a polyethoxysorbitanoleate. It is not only possible to use the mentioned Tween type (Tween 80) but also other Tween types for the purposes of the present invention.
- the particles are suspended or slurried, respectively, in a fluid inert medium. It has been found advantageous to choose a ratio of two volume parts of the suspending agent and one volume part of the solid particles or polymer particles, respectively.
- a gel which is known per se and is degraded within the body, for instance on the basis of gelatine, is used as a suspending agent.
- suspending agent By using a suspending agent it is easier to inject the solid particles as used according to the present invention with the help of an injection syringe for instance intracutenously. It is for instance possible to use a 20 G to 27 G cannula for such an injection.
- PMMA-beads with a smooth, smoothed off surface having different diameters for instance from 40 to 80 ⁇ m as well as from 15 to 60 ⁇ m, have been used.
- a mixture out of 0.5 ml ethylalcohol, 0.5 ml Tween and 9 ml water has been used as suspending agent.
- Such PMMA-beads or pellets, respectively, are known per se and are commercially available.
- the suspending agent which prevents the small beads from settling in the injection syringe due to gravitation such that an injection would be impossible, are mixed with the PMMA-beads before the injection in a ratio of about 1 volume part beads and 2 volume parts suspending agent.
- the alloplastic implant according to the invention was injected into male wistar rats, weighing 200 to 250 g and being completely anaesthetised with Nembutal, at four places in an amount of 0.5 ml with the help of a 20 G cannula intracutenously into the peritoneal skin. It was the intention to use the peritoneal skin of the animals since it is much softer and more flexible than the skin on the backside. After the injection, small weals formed at the injection site due to the injected volume. This, however, was also the case when the suspending agent was injected alone.
- the alloplastic implant of the present invention was injected into 39 animals. At days 3, 6, 9, 12, 15, 21 and 28 as well as 8, 12, 16, 20, 24 and 28 weeks after the injection three of the test animals were sacrificed. The peritoneal skin was then shaved with the help of a depilatory cream. At the injection site the beads, which were still visible but did not project anymore, were cut out together with a part of the peritoneal skin and investigated.
- Monocytes migrate during the first three days after the injection of the PMMA-beads used into the area of the injection. Then a differentiation of the monocytes takes place.
- the different forms of said differentiation can be recognised after about 6 d after the application of the foreign bodies. It is possible to recognise macrophages, foreign body-giant cells and fibrocytes. Said process of differentiation lasts until about the 16th week after the implant of the invention has been injected.
- the process of differentiation is however, limited mainly to the fibrocytes which, after a further transformation to fibrinfibers, shield the PMMA-beads against the animal body.
- the fibrotic growth of connective tissue is a natural reaction to the lesion of the tissue caused by the injection cannula. Said fibrotic reaction breaks down completely already after a couple of weeks due to the smooth surface and the chemical inertness of the PMMA-beads. From then on said beads remain in the tissue without reaction.
- the PMMA-beads which have been inserted into the body, are encapsulated by a delicate capsel of connective tissue or are embedded into connective-tissue fibers, respectively, and remain stationary in the tissue.
- suspending agent is by the way not mandatory since the above described PMMA-beads can be injected also without a suspending agent into the body.
- the beads used float better in the suspending agent it is also possible to replace the tenside mentioned in the beginning by charging the beads in the same sense. Than they repell mutually and float better in the medium of the suspending agent which can consist in this case exclusively of water, alcohol or a mixture thereof.
- said beads can be treated in such a way that the beads already completely cured are molten once again at the surface and than charged in an electric field.
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Dental Preparations (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (15)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3841401 | 1988-12-08 | ||
DE3841401A DE3841401A1 (en) | 1988-12-08 | 1988-12-08 | ALLOPLASTIC IMPLANT |
PCT/EP1989/001508 WO1990006093A1 (en) | 1988-12-08 | 1989-12-08 | Alloplastic implant |
Publications (1)
Publication Number | Publication Date |
---|---|
US5344452A true US5344452A (en) | 1994-09-06 |
Family
ID=6368743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/572,975 Expired - Lifetime US5344452A (en) | 1988-12-08 | 1989-12-08 | Alloplastic implant |
Country Status (8)
Country | Link |
---|---|
US (1) | US5344452A (en) |
EP (1) | EP0406375B1 (en) |
AT (1) | ATE119012T1 (en) |
BR (1) | BR8907235A (en) |
DE (2) | DE3841401A1 (en) |
ES (1) | ES2071812T3 (en) |
HK (1) | HK1004519A1 (en) |
WO (1) | WO1990006093A1 (en) |
Cited By (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5632774A (en) * | 1995-01-17 | 1997-05-27 | Babian; Hamik | In-the-shell hydration to make implant filler material and prosthesis employing same |
US5843185A (en) * | 1996-10-23 | 1998-12-01 | Leon Rolden; Carlos R. | Keratoprosthesis and method of corneal replacement |
US5922025A (en) * | 1992-02-11 | 1999-07-13 | Bristol-Myers Squibb Company | Soft tissue augmentation material |
US6261323B1 (en) * | 1996-12-19 | 2001-07-17 | Mateus Sommer Neto | Process of composition for medical use |
WO2001074418A2 (en) | 2000-03-31 | 2001-10-11 | Artes Medical Usa, Inc. | Urethra surgical device |
US20010056301A1 (en) * | 2000-03-13 | 2001-12-27 | Goupil Dennis W. | Hydrogel biomedical articles |
US6335028B1 (en) | 1998-03-06 | 2002-01-01 | Biosphere Medical, Inc. | Implantable particles for urinary incontinence |
US6436424B1 (en) | 2000-03-20 | 2002-08-20 | Biosphere Medical, Inc. | Injectable and swellable microspheres for dermal augmentation |
US20020187172A1 (en) * | 2001-06-08 | 2002-12-12 | Philippe Reb | Colloidal metal labeled microparticles and methods for producing and using the same |
US20030211165A1 (en) * | 2000-03-24 | 2003-11-13 | Jean-Marie Vogel | Microspheres for active embolization |
US20030211073A1 (en) * | 2000-03-13 | 2003-11-13 | Goupil Dennis W. | Tissue bulking and coating compositions |
US20030223956A1 (en) * | 2000-03-13 | 2003-12-04 | Goupil Dennis W. | Embolic compositions |
US6660301B1 (en) | 1998-03-06 | 2003-12-09 | Biosphere Medical, Inc. | Injectable microspheres for dermal augmentation and tissue bulking |
US6716251B1 (en) | 1997-06-13 | 2004-04-06 | Aventis Pharmaceuticals Holdings, Inc. | Implant for subcutaneous or intradermal injection |
US20040185021A1 (en) * | 1992-02-11 | 2004-09-23 | Bioform Inc. | Tissue augmentation material and method |
US20040225276A1 (en) * | 2003-03-13 | 2004-11-11 | Burgess Cheryl M. | Methods of administering a material into a patient for dermal enhancement |
US20050209695A1 (en) * | 2004-03-15 | 2005-09-22 | De Vries Jan A | Vertebroplasty method |
WO2006026554A1 (en) * | 2004-08-30 | 2006-03-09 | Neville Alleyne | Method of using an implant for treatment of ligaments and tendons |
WO2006026731A1 (en) * | 2004-08-30 | 2006-03-09 | Spineovations, Inc. | Method of treating spinal internal disk derangement |
US20060088476A1 (en) * | 2004-10-25 | 2006-04-27 | Polyzenix Gmbh | Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
US20060094871A1 (en) * | 2003-01-27 | 2006-05-04 | Abr Invent | Ceramic-based injectable implants which are used to fill wrinkles, cutaneous depressions and scars, and preparation method thereof |
US7060287B1 (en) | 1992-02-11 | 2006-06-13 | Bioform Inc. | Tissue augmentation material and method |
US20060246137A1 (en) * | 2003-07-30 | 2006-11-02 | Laurence Hermitte | Complex matrix for biomedical use |
US20060257488A1 (en) * | 2005-05-10 | 2006-11-16 | Cytophil, Inc. | Injectable hydrogels and methods of making and using same |
WO2006138669A2 (en) * | 2005-06-16 | 2006-12-28 | Artes Medical, Inc. | Life-like anatomic feature for testing injection of soft tissue fillers |
US20070003584A1 (en) * | 2005-06-16 | 2007-01-04 | Russell Anderson | Liquid crystal polymer syringes and containers and methods of use for long term storage of filler materials |
US20070055090A1 (en) * | 2004-08-12 | 2007-03-08 | Navotek Medical Ltd. | Medical Treatment System and Method |
US20070093907A1 (en) * | 2005-10-26 | 2007-04-26 | Goupil Dennis W | Hydrogel spinal disc implants with swellable articles |
US20070102010A1 (en) * | 2005-10-07 | 2007-05-10 | Lemperle Stefan M | Naso-pharyngeal tissue engineering |
US20070184087A1 (en) * | 2006-02-06 | 2007-08-09 | Bioform Medical, Inc. | Polysaccharide compositions for use in tissue augmentation |
US20070205373A1 (en) * | 2004-08-12 | 2007-09-06 | Navotek Medical Ltd. | Localization of a Radioactive Source Within a Body of a Subject |
US20080096976A1 (en) * | 2006-10-24 | 2008-04-24 | Neville Alleyne | Method of treating spinal internal disk derangement |
US20080107744A1 (en) * | 2006-11-06 | 2008-05-08 | Jack Fa-De Chu | Injectable hollow tissue filler |
US20080118569A1 (en) * | 2000-03-20 | 2008-05-22 | Biosphere Medical, Inc. | Injectable microspheres for tissue construction |
US20080262473A1 (en) * | 2004-10-19 | 2008-10-23 | Navotek Medical Ltd. | Locating a Catheter Tip Using a Tracked Guide |
US20080299172A1 (en) * | 2007-06-04 | 2008-12-04 | Stuart Young | Tissue repair implant |
EP2005944A1 (en) | 2001-09-12 | 2008-12-24 | ViRexx Medical Corporation | Vascular occlusion solid-phase agent with immobilised platelet binding agent |
US20090110736A1 (en) * | 2007-10-29 | 2009-04-30 | Ayman Boutros | Alloplastic injectable dermal filler and methods of use thereof |
US20090131734A1 (en) * | 2006-02-16 | 2009-05-21 | Navotek Medical Ltd. | Implantable medical marker and methods of preparation thereof |
US20090127459A1 (en) * | 2004-08-12 | 2009-05-21 | Navotek Medical Ltd. | Localization of a Radioactive Source |
US20090156709A1 (en) * | 2007-12-17 | 2009-06-18 | Anna Love | Soft tissue filler |
US20090311328A1 (en) * | 2006-03-31 | 2009-12-17 | Csir | Bulking of Soft Tissue |
US20100004700A1 (en) * | 2008-03-05 | 2010-01-07 | Neville Alleyne | Method of treating tissue with a suspenson of tricalcium hydroxyapatite microspheres |
US20100004699A1 (en) * | 2008-03-05 | 2010-01-07 | Neville Alleyne | Methods and compositions for minimally invasive capsular augmentation of canine coxofemoral joints |
US20100010549A1 (en) * | 2008-03-05 | 2010-01-14 | Neville Alleyne | device and method of minimally invasive extracapsular ligamentous augmentation for canine stifle ligament injuries |
US20100042041A1 (en) * | 2008-08-18 | 2010-02-18 | Navotek Medical Ltd. | Implantation device for soft tissue markers and other implants |
US7666333B2 (en) | 2004-06-01 | 2010-02-23 | Boston Scientific Scimed, Inc. | Embolization |
US7727555B2 (en) | 2005-03-02 | 2010-06-01 | Boston Scientific Scimed, Inc. | Particles |
US7736671B2 (en) | 2004-03-02 | 2010-06-15 | Boston Scientific Scimed, Inc. | Embolization |
WO2010078538A2 (en) | 2009-01-03 | 2010-07-08 | Russell Anderson | Enhanced carriers for the delivery of microparticles to bodily tissues and fluids |
US20100285078A1 (en) * | 2007-10-29 | 2010-11-11 | Ayman Boutros | Alloplastic injectable dermal filler and methods of use thereof |
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US8226926B2 (en) | 2005-05-09 | 2012-07-24 | Biosphere Medical, S.A. | Compositions and methods using microspheres and non-ionic contrast agents |
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Also Published As
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DE3841401C2 (en) | 1990-12-20 |
WO1990006093A1 (en) | 1990-06-14 |
EP0406375B1 (en) | 1995-03-01 |
HK1004519A1 (en) | 1998-11-27 |
ES2071812T3 (en) | 1995-07-01 |
DE58909072D1 (en) | 1995-04-06 |
BR8907235A (en) | 1991-03-05 |
EP0406375A1 (en) | 1991-01-09 |
ATE119012T1 (en) | 1995-03-15 |
DE3841401A1 (en) | 1990-06-13 |
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