US4916140B1 - - Google Patents

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Publication number
US4916140B1
US4916140B1 US25047888A US4916140B1 US 4916140 B1 US4916140 B1 US 4916140B1 US 25047888 A US25047888 A US 25047888A US 4916140 B1 US4916140 B1 US 4916140B1
Authority
US
United States
Prior art keywords
pyrazolopyridin
epilepsy
carboxylates
virtue
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
Inventor
G Palfreyman Michael
P Miller Francis
Mir Anis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Priority to US07/250,478 priority Critical patent/US4916140A/en
Assigned to MERRELL DOW FRANCE ET CIE reassignment MERRELL DOW FRANCE ET CIE ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: MIR, ANIS
Assigned to MERRELL DOW PHARMACEUTICALS INC., reassignment MERRELL DOW PHARMACEUTICALS INC., ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: MILLER, FRANCIS P., PALFREYMAN, MICHAEL G.
Assigned to MERRELL DOW PHARMACEUTICALS, INC., A CORP. OF DE. reassignment MERRELL DOW PHARMACEUTICALS, INC., A CORP. OF DE. ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: MERRELL DOW FRANCE ET CIE
Priority to AU41692/89A priority patent/AU619044B2/en
Priority to ZA897252A priority patent/ZA897252B/en
Priority to ES89117736T priority patent/ES2058430T3/en
Priority to EP89117736A priority patent/EP0361382B1/en
Priority to DE89117736T priority patent/DE68907163T2/en
Priority to AT89117736T priority patent/ATE90562T1/en
Priority to KR1019890013794A priority patent/KR0147832B1/en
Priority to JP01248274A priority patent/JP3131209B2/en
Priority to IE309389A priority patent/IE62009B1/en
Priority to DK475989A priority patent/DK475989A/en
Publication of US4916140A publication Critical patent/US4916140A/en
Application granted granted Critical
Priority to PH40371A priority patent/PH27112A/en
Publication of US4916140B1 publication Critical patent/US4916140B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The disclosure pertains to certain pyrazolopyridin-carboxylates which are calcium channel blockers and possess anticonvulsant properties. By virtue of this activity, the compounds are useful in the treatment of epilepsy.
US07/250,478 1988-09-28 1988-09-28 Antiepileptic pyrazolopyridines Expired - Fee Related US4916140A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
US07/250,478 US4916140A (en) 1988-09-28 1988-09-28 Antiepileptic pyrazolopyridines
AU41692/89A AU619044B2 (en) 1988-09-28 1989-09-22 Antiepileptic pyrazolopyridines
ZA897252A ZA897252B (en) 1988-09-28 1989-09-22 Antiepileptic pyrazolopyridines
JP01248274A JP3131209B2 (en) 1988-09-28 1989-09-26 Antiepileptic pyrazolopyridines
EP89117736A EP0361382B1 (en) 1988-09-28 1989-09-26 Antiepileptic pyrazolopyridines
AT89117736T ATE90562T1 (en) 1988-09-28 1989-09-26 ANTI-PILEPTIC PYRAZOLOPYRIDINE.
KR1019890013794A KR0147832B1 (en) 1988-09-28 1989-09-26 Antiepileptic pyrazolopyridines
DE89117736T DE68907163T2 (en) 1988-09-28 1989-09-26 Antiepileptic pyrazolopyridines.
ES89117736T ES2058430T3 (en) 1988-09-28 1989-09-26 A METHOD FOR THE PREPARATION OF A USEFUL PHARMACEUTICAL COMPOSITION IN THE TREATMENT OF EPILEPSY.
IE309389A IE62009B1 (en) 1988-09-28 1989-09-27 Antiepileptic pyrazolopyridines
DK475989A DK475989A (en) 1988-09-28 1989-09-27 USE OF PYRAZOLOPYRIDINE DERIVATIVES OR PHYSIOLOGICALLY ACCEPTABLE SALTS THEREOF IN PHARMACEUTICALS FOR THE TREATMENT OF EPILEPSY
PH40371A PH27112A (en) 1988-09-28 1990-04-11 Antiepilectic pyrazolopyridines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/250,478 US4916140A (en) 1988-09-28 1988-09-28 Antiepileptic pyrazolopyridines

Publications (2)

Publication Number Publication Date
US4916140A US4916140A (en) 1990-04-10
US4916140B1 true US4916140B1 (en) 1992-12-29

Family

ID=22947925

Family Applications (1)

Application Number Title Priority Date Filing Date
US07/250,478 Expired - Fee Related US4916140A (en) 1988-09-28 1988-09-28 Antiepileptic pyrazolopyridines

Country Status (12)

Country Link
US (1) US4916140A (en)
EP (1) EP0361382B1 (en)
JP (1) JP3131209B2 (en)
KR (1) KR0147832B1 (en)
AT (1) ATE90562T1 (en)
AU (1) AU619044B2 (en)
DE (1) DE68907163T2 (en)
DK (1) DK475989A (en)
ES (1) ES2058430T3 (en)
IE (1) IE62009B1 (en)
PH (1) PH27112A (en)
ZA (1) ZA897252B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005534713A (en) * 2002-08-07 2005-11-17 三菱ウェルファーマ株式会社 Dihydropyrazolopyridine compounds
CN104078763B (en) 2014-06-11 2017-02-01 小米科技有限责任公司 Mimo antenna and electronic equipment

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79111B (en) * 1982-12-20 1984-10-02 Lepetit Spa

Also Published As

Publication number Publication date
ZA897252B (en) 1990-06-27
DE68907163T2 (en) 1993-09-30
JPH02129122A (en) 1990-05-17
KR900004343A (en) 1990-04-12
IE893093L (en) 1990-03-28
DK475989A (en) 1990-03-29
DE68907163D1 (en) 1993-07-22
ATE90562T1 (en) 1993-07-15
EP0361382A2 (en) 1990-04-04
EP0361382A3 (en) 1991-04-24
US4916140A (en) 1990-04-10
EP0361382B1 (en) 1993-06-16
JP3131209B2 (en) 2001-01-31
AU619044B2 (en) 1992-01-16
DK475989D0 (en) 1989-09-27
KR0147832B1 (en) 1998-08-17
PH27112A (en) 1993-03-16
AU4169289A (en) 1990-04-05
ES2058430T3 (en) 1994-11-01
IE62009B1 (en) 1994-12-14

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Legal Events

Date Code Title Description
AS Assignment

Owner name: MERRELL DOW PHARMACEUTICALS, INC., 2110 EAST GALBR

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:MERRELL DOW FRANCE ET CIE;REEL/FRAME:004977/0888

Effective date: 19880921

Owner name: MERRELL DOW PHARMACEUTICALS INC.,

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:PALFREYMAN, MICHAEL G.;MILLER, FRANCIS P.;REEL/FRAME:004977/0890

Effective date: 19880928

Owner name: MERRELL DOW FRANCE ET CIE

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:MIR, ANIS;REEL/FRAME:004977/0892

Effective date: 19880916

Owner name: MERRELL DOW FRANCE ET CIE,FRANCE

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MIR, ANIS;REEL/FRAME:004977/0892

Effective date: 19880916

Owner name: MERRELL DOW PHARMACEUTICALS, INC., A CORP. OF DE.,

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MERRELL DOW FRANCE ET CIE;REEL/FRAME:004977/0888

Effective date: 19880921

RR Request for reexamination filed

Effective date: 19901029

B1 Reexamination certificate first reexamination
REMI Maintenance fee reminder mailed
LAPS Lapse for failure to pay maintenance fees
FP Lapsed due to failure to pay maintenance fee

Effective date: 19940410

STCH Information on status: patent discontinuation

Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362