US4781923A - Antiseptic gels - Google Patents

Antiseptic gels Download PDF

Info

Publication number
US4781923A
US4781923A US07/075,440 US7544087A US4781923A US 4781923 A US4781923 A US 4781923A US 7544087 A US7544087 A US 7544087A US 4781923 A US4781923 A US 4781923A
Authority
US
United States
Prior art keywords
hydrogen peroxide
gel
antiseptic
composition
polyglycerylmethacrylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
US07/075,440
Inventor
Michael A. Pellico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to US07/075,440 priority Critical patent/US4781923A/en
Application granted granted Critical
Publication of US4781923A publication Critical patent/US4781923A/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/08—Preparations for bleaching the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/40—Peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms

Definitions

  • This invention relates to antiseptic compositions and, more particularly, to antiseptic gels incorporating hydrogen peroxide as an antiseptic agent.
  • Aqueous solutions containing hydrogen peroxide at a concentration level from about 1 to about 10% have long been known for their antiseptic properties. While it is reported in the literature that the antiseptic characteristics of hydrogen peroxide arise by virtue of the oxidizing properties of this composition, it has also been suggested that the mode of action of hydrogen peroxide is through the production of a strong oxidant, namely, the hydroxyl free radical.
  • a strong oxidant namely, the hydroxyl free radical
  • an antiseptic gel composition comprising polyglycerylmethacrylate hydrate gel and hydrogen peroxide.
  • a method for preparing an antiseptic gel composition which comprises admixing an aqueous solution of hydrogen peroxide with polyglycerylmethacrylate hydrate gel.
  • a method for treating an infectious site which comprises applying to the infectious site an antiseptic gel composition comprising polyglycerylmethacrylate hydrate gel and hydrogen peroxide.
  • the antiseptic gel compositions of this invention comprise polyglycerylmethacrylate hydrate gel and hydrogen peroxide.
  • the polyglycerylmethacrylate hydrate gel which can be utilized in this invention is available under the trademark Lubrajel from Guardian Chemical Corporation, 230 Marcus Boulevard., Hauppauge, Long Island, N.Y. 11787.
  • the gel is characterized as a clathrate formed by the reaction of sodium glycerate with an acrylic acid polymer, stablized with a small amount of propylene glycol, followed by controlled hydration of the resulting product.
  • Hydrogen peroxide is advantageously incorporated into the hydrated polymeric gel complex as a constituent of an aqueous solution of hydrogen peroxide as, for example, an aqueous solution containing about 35 wt. % hydrogen peroxide.
  • the antiseptic gel can be further formulated with optional, special purpose additives such as humectants, emollients, local anesthetics, nonionic surfactants, buffers, and the like, as well as enzymatic inhibitors specific to enzymes which effect rapid degradation of hydrogen peroxide.
  • humectants include glycerol, sorbitol and hydrated starch solutions; an illustrative emollient is wintergreen oil; an illustrative local anesthetic is benzocaine.
  • Hydrogen peroxide is generally present in the antiseptic gel in an amount from about 0.5 to about 15 wt. % and, preferably, in an amount from about 1 to about 11 wt. %.
  • concentration of polygylcerylmethacrylate hydrate is so selected as to provide the antiseptic gel composition with a desired consistency.
  • polygylcerylmethacrylate hydrate is present in the antiseptic gel in an amount from about 45 to about 96 wt. %. Water and any optional additives make up the balance of the composition to 100 wt. %.
  • the antiseptic gel compositions can be prepared by admixing an aqueous solution of hydrogen peroxide and any optional additives with polygylcerylmethacrylate hydrate wherein the amount of hydrogen peroxide solution is so selected as to provide the antiseptic gel with a hydrogen peroxide concentration from about 0.5 to about 15 wt. % and, preferably with a hydrogen peroxide concentration from about 1 to about 11 wt. %.
  • the admixing step is advantageously carried out in plastic, stainless steel or glass lined vessels with a mixer suitable for use with compositions having a gel consistency.
  • the polygylcerylmethacrylate hydrate is generally present in the admixing step in an amount from about 45 to about 96 wt % with water and any optional additives comprising the balance of the ingredients to 100 wt. %.
  • the antiseptic gel composition comprising polygylcerylmethacrylate hydrate and hydrogen peroxide is used by applying it to an infectious site where, in contrast to aqueous hydrogen peroxide solutions, it does not flow away or run off from the area of application. Accordingly, its gel characteristics are such that it is safer to use if the area of application is near the eyes or any other body area which should not be in contact with hydrogen peroxide. Also, the hydrogen peroxide gel can be more effective than hydrogen peroxide solutions because the gel can remain in contact with the area of application longer than the liquid. A further advantage of the antiseptic gel over the hydrogen peroxide solution is that the gel forms a protective-type coating over the affected area.
  • This example illustrates an antiseptic gel containing 3.0 wt. % hydrogen peroxide.
  • This example illustrates an antiseptic gel containing 1.5 wt. % hydrogen peroxide.
  • This example illustrates a low viscosity antiseptic gel containing 3.0 wt. % hydrogen peroxide.
  • This example illustrates an antiseptic gel that incorporates a humectant to provide the gel with enhanced moisturizing properties.
  • This example illustrates an antiseptic gel containing 10.5 wt. % hydrogen peroxide and which is useful for bleaching hair or disinfecting.
  • This example illustrates an antiseptic gel containing 3.0 wt. % hydrogen peroxide, a humectant and a local anesthetic.
  • This example illustrates an antiseptic gel containing 3.0 wt. % hydrogen peroxide and an emollient to provide a soothing effect.
  • compositions of this invention it is important to note that hydrogen peroxide is an oxidizing agent and Lubrajel is moderately acidic and, accordingly, it is important to take these characteristics into consideration in the selection of optional additives for incorporation into the antiseptic gels. Also, it is important to select optional additives that do not have a significant adverse effect on either hydrogen peroxide or Lubrajel.
  • the use of salt in the formulation should be limited in order to avoid degradation of Lubrajel.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

An antiseptic gel composition comprising polyglycerylmethacrylate hydrate gel and hydrogen peroxide is prepared by admixing an aqueous solution of hydrogen peroxide with polyglycerylmethacrylate hydrate gel so as to provide a gel composition containing from about 0.5 to about 15 wt. % hydrogen peroxide. The composition is stable and, at a suitable hydrogen peroxide concentration, is adapted for adherent application to infectious dermal sites.

Description

BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to antiseptic compositions and, more particularly, to antiseptic gels incorporating hydrogen peroxide as an antiseptic agent. 2. Prior Art
Aqueous solutions containing hydrogen peroxide at a concentration level from about 1 to about 10% have long been known for their antiseptic properties. While it is reported in the literature that the antiseptic characteristics of hydrogen peroxide arise by virtue of the oxidizing properties of this composition, it has also been suggested that the mode of action of hydrogen peroxide is through the production of a strong oxidant, namely, the hydroxyl free radical. However, the early use of low concentration, hydrogen peroxide solutions as antiseptic compositions led to unfavorable results because the solutions tended to be unstable and the application of such solutions to tissue containing significant levels of catalase resulted in rapid deactivation of the hydrogen peroxide.
More recently, there has been an upsurge of interest in the utilization of hydrogen peroxide solutions as antiseptic compositions. These solutions are generally available as aqueous compositions containing 3.0 wt. % hydrogen peroxide. However, these aqueous compositions have certain disadvantages. One notable disadvantage is in the application of the liquid composition to skin cuts or abrasions where the amount utilized compared to the amount poured is minimal since most of the liquid immediately flows away from the application site. Another problem encountered with the liquid is that it is difficult to apply to certain areas of the body and must be cautiously applied to other areas of the body as, for example, in the vicinity of the eyes. Also, since hydrogen peroxide solutions may degrade faster when agitated, there utilization as carry-on antiseptic compositions in camping, hiking, and like activities is limited.
Accordingly, it would be advantageous to provide a stable and adherent hydrogen peroxide composition which overcomes the disadvantages that are present in the aqueous hydrogen peroxide solutions.
SUMMARY OF THE INVENTION
In accordance with one aspect of this invention, there is provided an antiseptic gel composition comprising polyglycerylmethacrylate hydrate gel and hydrogen peroxide.
In accordance with a second aspect of this invention, there is provided a method for preparing an antiseptic gel composition which comprises admixing an aqueous solution of hydrogen peroxide with polyglycerylmethacrylate hydrate gel.
In accordance with a third aspect of this invention, there is provided a method for treating an infectious site which comprises applying to the infectious site an antiseptic gel composition comprising polyglycerylmethacrylate hydrate gel and hydrogen peroxide.
DETAILED DESCRIPTION
The antiseptic gel compositions of this invention comprise polyglycerylmethacrylate hydrate gel and hydrogen peroxide. The polyglycerylmethacrylate hydrate gel which can be utilized in this invention is available under the trademark Lubrajel from Guardian Chemical Corporation, 230 Marcus Blvd., Hauppauge, Long Island, N.Y. 11787. The gel is characterized as a clathrate formed by the reaction of sodium glycerate with an acrylic acid polymer, stablized with a small amount of propylene glycol, followed by controlled hydration of the resulting product.
The product specification for LUBRAJEL, which has the CTFA Name, "Polyglycerylmethacrylate and propylene glycol," is as follows:
______________________________________                                    
SPECIFICATION        CHARACTERISTIC                                       
______________________________________                                    
Form                 Viscous gel                                          
pH (as is)           5.0-6.0                                              
Viscosity, in cps at 20° C.                                        
                     300,000-400,000                                      
(Brookfield RTV)                                                          
Color                colorless                                            
Clarity              clear                                                
Specific gravity     1.3 g./ml.                                           
Water solubility     complete                                             
Conductivity, expressed as resis-                                         
                     80-90                                                
tance to current flow in micromho/cm                                      
Loss of weight, %, on exposure                                            
                     16-18                                                
to air in glass beakers at                                                
20° C., 18 months, 70% R.H.                                        
Decomposition at 250° F./1 hr.                                     
                     practically none                                     
Color change when exposed to                                              
                     colorless to straw                                   
250° F. for 1 hour                                                 
Shelf stability (sealed), on                                              
                     100%                                                 
storage for 3 years at 20° C.,                                     
% undecomposed                                                            
______________________________________
Hydrogen peroxide is advantageously incorporated into the hydrated polymeric gel complex as a constituent of an aqueous solution of hydrogen peroxide as, for example, an aqueous solution containing about 35 wt. % hydrogen peroxide.
The antiseptic gel can be further formulated with optional, special purpose additives such as humectants, emollients, local anesthetics, nonionic surfactants, buffers, and the like, as well as enzymatic inhibitors specific to enzymes which effect rapid degradation of hydrogen peroxide. Illustrative humectants include glycerol, sorbitol and hydrated starch solutions; an illustrative emollient is wintergreen oil; an illustrative local anesthetic is benzocaine.
Hydrogen peroxide is generally present in the antiseptic gel in an amount from about 0.5 to about 15 wt. % and, preferably, in an amount from about 1 to about 11 wt. %. The concentration of polygylcerylmethacrylate hydrate is so selected as to provide the antiseptic gel composition with a desired consistency. In general, polygylcerylmethacrylate hydrate is present in the antiseptic gel in an amount from about 45 to about 96 wt. %. Water and any optional additives make up the balance of the composition to 100 wt. %.
The antiseptic gel compositions can be prepared by admixing an aqueous solution of hydrogen peroxide and any optional additives with polygylcerylmethacrylate hydrate wherein the amount of hydrogen peroxide solution is so selected as to provide the antiseptic gel with a hydrogen peroxide concentration from about 0.5 to about 15 wt. % and, preferably with a hydrogen peroxide concentration from about 1 to about 11 wt. %. The admixing step is advantageously carried out in plastic, stainless steel or glass lined vessels with a mixer suitable for use with compositions having a gel consistency. The polygylcerylmethacrylate hydrate is generally present in the admixing step in an amount from about 45 to about 96 wt % with water and any optional additives comprising the balance of the ingredients to 100 wt. %.
The antiseptic gel composition comprising polygylcerylmethacrylate hydrate and hydrogen peroxide is used by applying it to an infectious site where, in contrast to aqueous hydrogen peroxide solutions, it does not flow away or run off from the area of application. Accordingly, its gel characteristics are such that it is safer to use if the area of application is near the eyes or any other body area which should not be in contact with hydrogen peroxide. Also, the hydrogen peroxide gel can be more effective than hydrogen peroxide solutions because the gel can remain in contact with the area of application longer than the liquid. A further advantage of the antiseptic gel over the hydrogen peroxide solution is that the gel forms a protective-type coating over the affected area.
EXAMPLES
The following examples further illustrate the invention. As used in the examples, "Lubrajel" is the trademark for polyglycerylmethacrylate hydrate gel stablized with a small amount of propylene glycol and the expression "Hydrogen peroxide (35%)" designates an aqueous solution containing 35 wt. % hydrogen peroxide.
EXAMPLE 1
This example illustrates an antiseptic gel containing 3.0 wt. % hydrogen peroxide.
______________________________________                                    
COMPOSITION      PARTS BY WEIGHT                                          
______________________________________                                    
Lubrajel         10.6                                                     
Hydrogen Peroxide (35%)                                                   
                 1.0                                                      
______________________________________
EXAMPLE 2
This example illustrates an antiseptic gel containing 1.5 wt. % hydrogen peroxide.
______________________________________                                    
COMPOSITION      PARTS BY WEIGHT                                          
______________________________________                                    
Lubrajel         11.1                                                     
Hydrogen Peroxide (35%)                                                   
                 0.5                                                      
______________________________________
EXAMPLE 3
This example illustrates a low viscosity antiseptic gel containing 3.0 wt. % hydrogen peroxide.
______________________________________                                    
COMPOSITION      PARTS BY WEIGHT                                          
______________________________________                                    
Lubrajel         5.6                                                      
Water (deionized)                                                         
                 5.0                                                      
Hydrogen Peroxide (35%)                                                   
                 1.0                                                      
______________________________________
EXAMPLE 4
This example illustrates an antiseptic gel that incorporates a humectant to provide the gel with enhanced moisturizing properties.
______________________________________                                    
COMPOSITION      PARTS BY WEIGHT                                          
______________________________________                                    
Lubrajel         5.6                                                      
Glycerol (U.S.P.)                                                         
                 5.6                                                      
Hydrogen Peroxide (35%)                                                   
                 1.0                                                      
______________________________________
EXAMPLE 5
This example illustrates an antiseptic gel containing 10.5 wt. % hydrogen peroxide and which is useful for bleaching hair or disinfecting.
______________________________________                                    
COMPOSITION      PARTS BY WEIGHT                                          
______________________________________                                    
Lubrajel         8.1                                                      
Hydrogen Peroxide (35%)                                                   
                 3.5                                                      
______________________________________
EXAMPLE 6
This example illustrates an antiseptic gel containing 3.0 wt. % hydrogen peroxide, a humectant and a local anesthetic.
______________________________________                                    
COMPOSITION      PARTS BY WEIGHT                                          
______________________________________                                    
Lubrajel         6.0                                                      
Hydrogen Peroxide (35%)                                                   
                 1.0                                                      
Water (Deionized)                                                         
                 1.5                                                      
Oleic acid decyl ester                                                    
                 1.5                                                      
FD&C Color Red #40                                                        
                 0.003                                                    
Benzocaine       0.5                                                      
______________________________________
EXAMPLE 7
This example illustrates an antiseptic gel containing 3.0 wt. % hydrogen peroxide and an emollient to provide a soothing effect.
______________________________________                                    
COMPOSITION      PARTS BY WEIGHT                                          
______________________________________                                    
Lubrajel         10.0                                                     
Hydrogen Peroxide (35%)                                                   
                 1.0                                                      
Wintergreen      0.6                                                      
______________________________________
As to the compositions of this invention, it is important to note that hydrogen peroxide is an oxidizing agent and Lubrajel is moderately acidic and, accordingly, it is important to take these characteristics into consideration in the selection of optional additives for incorporation into the antiseptic gels. Also, it is important to select optional additives that do not have a significant adverse effect on either hydrogen peroxide or Lubrajel. In this connection, the use of salt in the formulation should be limited in order to avoid degradation of Lubrajel.
In view of the foregoing description and examples, it will become apparent to those of ordinary skill in the art that equivalent modifications thereof may be made without departing from the spirit and scope of this invention

Claims (20)

That which is claimed is:
1. An antiseptic gel composition comprising polyglycerylmethacrylate hydrate gel and hydrogen peroxide.
2. The composition of claim 1 wherein the concentration of hydrogen peroxide is from about 0.5 to about 15 wt. %.
3. The composition of claim 1 wherein the concentration of hydrogen peroxide is from about 1 to about 11 wt. %.
4. The composition of claim 1 which further includes a humectant.
5. The composition of claim 1 which further includes an emollient.
6. The composition of claim 1 which further includes a local anesthetic.
7. A method for preparing an antiseptic gel composition which comprises admixing an aqueous solution of hydrogen peroxide with polyglycerylmethacrylate hydrate gel.
8. The method of claim 7 wherein the amount of hydrogen peroxide solution is so selected as to provide the antiseptic gel with a hydrogen peroxide concentration from about 0.5 to about 15 wt. %.
9. The method of claim 7 wherein the amount of hydrogen peroxide solution is so selected as to provide the antiseptic gel with a hydrogen peroxide concentration from about 1 to about 11 wt. %.
10. The method of claim 7 wherein the polyglycerylmethacrylate hydrate gel has a viscosity from about 300,000 to about 400,000 centipoises at 20° C.
11. The method of claim 7 wherein the polyglycerylmethacrylate hydrate gel has a specific gravity of about 1.3 grams per milliliter.
12. The method of claim 7 which further includes admixing a humectant with said gel.
13. The method of claim 7 which further includes admixing an emollient with said gel.
14. The method of claim 7 which further includes admixing a local anesthetic with said gel.
15. A method for treating an infectious site which comprises applying to said site an antiseptic gel composition containing polyglycerylmethacrylate hydrate gel and hydrogen peroxide.
16. The method of claim 15 wherein the concentration of hydrogen peroxide in the antiseptic gel is from about 0.5 to about 15 wt. %.
17. The method of claim 15 wherein the concentration of hydrogen peroxide in the antiseptic gel is from about 1 to about 11 wt. %.
18. The method of claim 15 wherein the antiseptic gel further includes a humectant.
19. The method of claim 15 wherein the antiseptic gel further includes an emollient.
20. The method of claim 15 wherein the antiseptic gel further includes a local anesthetic.
US07/075,440 1987-07-20 1987-07-20 Antiseptic gels Expired - Fee Related US4781923A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US07/075,440 US4781923A (en) 1987-07-20 1987-07-20 Antiseptic gels

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/075,440 US4781923A (en) 1987-07-20 1987-07-20 Antiseptic gels

Publications (1)

Publication Number Publication Date
US4781923A true US4781923A (en) 1988-11-01

Family

ID=22125776

Family Applications (1)

Application Number Title Priority Date Filing Date
US07/075,440 Expired - Fee Related US4781923A (en) 1987-07-20 1987-07-20 Antiseptic gels

Country Status (1)

Country Link
US (1) US4781923A (en)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4895721A (en) * 1988-01-22 1990-01-23 Carter-Wallace Inc. Peroxide gel dentifrice compositions
US4983380A (en) * 1989-09-11 1991-01-08 Yarborough David K Composition for treatment of teeth and method of use
US5009885A (en) * 1989-09-11 1991-04-23 Yarborough David K Method of protecting the mucous membranes of the mouth while treating teeth
US5130124A (en) * 1991-05-01 1992-07-14 Isp Investments Inc. Stabilized, aqueous, film-forming antimicrobial compositions of hydrogen peroxide
WO1992019216A1 (en) * 1991-05-04 1992-11-12 The Procter & Gamble Company Skin and hair-care gel compositions
WO1994000159A1 (en) * 1992-06-29 1994-01-06 Allergan, Inc. Hydrogen peroxide-containing gels and contact lens disinfecting using same
US5405622A (en) * 1993-12-22 1995-04-11 Vernice; Joseph Gamma radiation resistant lubricating gel
US5536438A (en) * 1992-11-26 1996-07-16 The Procter & Gamble Company Multi-purpose liquid cleaning composition comprising nonionic surfactants of different HLB values
EP0829258A1 (en) * 1996-09-17 1998-03-18 L'oreal Oxidative composition in gel form and uses for dyeing, for permanent deformation or for decoloration of hair
US5741525A (en) * 1995-10-24 1998-04-21 Marshall University Research Corporation Vaginal pharmaceutical hydrogen peroxide composition
US5902600A (en) * 1992-12-21 1999-05-11 Healthpoint, Ltd. Hydrogel polymer wound dressing
WO2003030793A1 (en) * 2001-10-12 2003-04-17 Cns, Incorporated Hydrating nasal gel and applicator
WO2003037382A1 (en) * 2001-10-29 2003-05-08 Columbia Laboratories (Bermuda) Limited Low concentration of peroxide for treating or preventing vaginal infections
US6949262B1 (en) 2003-05-27 2005-09-27 Lousal Enterprises, Inc. Skin and mucosal treatment formulation
US6964782B1 (en) 2002-07-23 2005-11-15 Tec Labs, Inc. Stable hydrogen peroxide compositions, products and methods of use
US20070104665A1 (en) * 2005-10-11 2007-05-10 Dfb Pharmaceuticals, Inc. Surfactant-free dispersions, compositions, and use in topical formulations
WO2009138701A1 (en) * 2008-04-30 2009-11-19 Laboratoire D'evolution Dermatologique Composition for the treatment of seborrhoeic conditions
RU2650394C2 (en) * 2013-08-29 2018-04-11 Аркема Инк. Peroxide dispersions

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639574A (en) * 1967-10-25 1972-02-01 Basf Wyandotte Corp Stable hydrogen peroxide gels
US3954974A (en) * 1972-06-09 1976-05-04 Paul Herzog Disinfectant for the surface of human body parts containing hydrogen peroxide
US4071508A (en) * 1975-02-11 1978-01-31 Plastomedical Sciences, Inc. Anionic hydrogels based on hydroxyalkyl acrylates and methacrylates
GB2068225A (en) * 1980-06-09 1981-08-12 Quinodern Ltd Dermatological compositions containing hydrogen peroxide
GB2076286A (en) * 1980-05-23 1981-12-02 Quinoderm Ltd Dermatological hydrogen peroxide compositions
GB2076285A (en) * 1980-05-23 1981-12-02 Quinoderm Ltd Dermatological compositions
US4428933A (en) * 1982-08-02 1984-01-31 King John R Composition for treating acne, method of manufacturing said composition, and method of treating skin
US4431631A (en) * 1983-01-03 1984-02-14 Colgate-Palmolive Company Aqueous oral solution
US4438102A (en) * 1982-08-10 1984-03-20 Ciro's Touch, Ltd. Method of promoting tissue growth
CH647145A5 (en) * 1981-03-24 1985-01-15 Paul Dr Med Herzog Cosmetic product
US4518585A (en) * 1978-05-01 1985-05-21 Sterling Drug Inc. Hydrogen peroxide disinfecting and sterilizing compositions
US4557935A (en) * 1981-03-17 1985-12-10 Biogram Ab Germicidal composition
JPH1158907A (en) * 1997-08-12 1999-03-02 Yamahachi Chem Kk Stamp

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639574A (en) * 1967-10-25 1972-02-01 Basf Wyandotte Corp Stable hydrogen peroxide gels
US3954974A (en) * 1972-06-09 1976-05-04 Paul Herzog Disinfectant for the surface of human body parts containing hydrogen peroxide
US4071508A (en) * 1975-02-11 1978-01-31 Plastomedical Sciences, Inc. Anionic hydrogels based on hydroxyalkyl acrylates and methacrylates
US4518585A (en) * 1978-05-01 1985-05-21 Sterling Drug Inc. Hydrogen peroxide disinfecting and sterilizing compositions
GB2076286A (en) * 1980-05-23 1981-12-02 Quinoderm Ltd Dermatological hydrogen peroxide compositions
GB2076285A (en) * 1980-05-23 1981-12-02 Quinoderm Ltd Dermatological compositions
GB2068225A (en) * 1980-06-09 1981-08-12 Quinodern Ltd Dermatological compositions containing hydrogen peroxide
US4557935A (en) * 1981-03-17 1985-12-10 Biogram Ab Germicidal composition
CH647145A5 (en) * 1981-03-24 1985-01-15 Paul Dr Med Herzog Cosmetic product
US4428933A (en) * 1982-08-02 1984-01-31 King John R Composition for treating acne, method of manufacturing said composition, and method of treating skin
US4438102A (en) * 1982-08-10 1984-03-20 Ciro's Touch, Ltd. Method of promoting tissue growth
US4431631A (en) * 1983-01-03 1984-02-14 Colgate-Palmolive Company Aqueous oral solution
JPH1158907A (en) * 1997-08-12 1999-03-02 Yamahachi Chem Kk Stamp

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4895721A (en) * 1988-01-22 1990-01-23 Carter-Wallace Inc. Peroxide gel dentifrice compositions
US4983380A (en) * 1989-09-11 1991-01-08 Yarborough David K Composition for treatment of teeth and method of use
US5009885A (en) * 1989-09-11 1991-04-23 Yarborough David K Method of protecting the mucous membranes of the mouth while treating teeth
US5130124A (en) * 1991-05-01 1992-07-14 Isp Investments Inc. Stabilized, aqueous, film-forming antimicrobial compositions of hydrogen peroxide
WO1992019216A1 (en) * 1991-05-04 1992-11-12 The Procter & Gamble Company Skin and hair-care gel compositions
WO1994000159A1 (en) * 1992-06-29 1994-01-06 Allergan, Inc. Hydrogen peroxide-containing gels and contact lens disinfecting using same
AU671661B2 (en) * 1992-06-29 1996-09-05 Allergan, Inc. Hydrogen peroxide-containing gels and contact lens disinfecting using same
US5536438A (en) * 1992-11-26 1996-07-16 The Procter & Gamble Company Multi-purpose liquid cleaning composition comprising nonionic surfactants of different HLB values
US5902600A (en) * 1992-12-21 1999-05-11 Healthpoint, Ltd. Hydrogel polymer wound dressing
US5405622A (en) * 1993-12-22 1995-04-11 Vernice; Joseph Gamma radiation resistant lubricating gel
US5741525A (en) * 1995-10-24 1998-04-21 Marshall University Research Corporation Vaginal pharmaceutical hydrogen peroxide composition
US5958461A (en) * 1995-10-24 1999-09-28 Marshall University Research Corporation Vaginal pharmaceutical compositions
EP0862441A4 (en) * 1995-10-24 1999-11-17 Marshall University Research C Vaginal pharmaceutical compositions containing a peroxide source
FR2753372A1 (en) * 1996-09-17 1998-03-20 Oreal GELIFIED OXIDIZING COMPOSITION AND USES FOR DYEING, PERMANENT DEFORMATION OR HAIR DECOLORATION
EP0829258A1 (en) * 1996-09-17 1998-03-18 L'oreal Oxidative composition in gel form and uses for dyeing, for permanent deformation or for decoloration of hair
US6180118B1 (en) 1996-09-17 2001-01-30 L'Or{acute over (e)}al Composition and its uses for the dyeing, permanent reshaping or bleaching of the hair
WO2003030793A1 (en) * 2001-10-12 2003-04-17 Cns, Incorporated Hydrating nasal gel and applicator
US20030091644A1 (en) * 2001-10-29 2003-05-15 Bologna William J. Low concentration of peroxide for treating or preventing vaginal infections
WO2003037382A1 (en) * 2001-10-29 2003-05-08 Columbia Laboratories (Bermuda) Limited Low concentration of peroxide for treating or preventing vaginal infections
AU2002346897B2 (en) * 2001-10-29 2008-04-17 Columbia Laboratories (Bermuda) Limited Low concentration of peroxide for treating or preventing vaginal infections
US7709026B2 (en) * 2001-10-29 2010-05-04 Columbia Laboratories, Inc. Low concentration of peroxide for treating or preventing vaginal infections
US6964782B1 (en) 2002-07-23 2005-11-15 Tec Labs, Inc. Stable hydrogen peroxide compositions, products and methods of use
US6949262B1 (en) 2003-05-27 2005-09-27 Lousal Enterprises, Inc. Skin and mucosal treatment formulation
US20070104665A1 (en) * 2005-10-11 2007-05-10 Dfb Pharmaceuticals, Inc. Surfactant-free dispersions, compositions, and use in topical formulations
US8128947B2 (en) 2005-10-11 2012-03-06 Dpt Laboratories, Ltd. Surfactant-free dispersions, compositions, and use in topical formulations
WO2009138701A1 (en) * 2008-04-30 2009-11-19 Laboratoire D'evolution Dermatologique Composition for the treatment of seborrhoeic conditions
RU2650394C2 (en) * 2013-08-29 2018-04-11 Аркема Инк. Peroxide dispersions

Similar Documents

Publication Publication Date Title
US4781923A (en) Antiseptic gels
CA2342856C (en) Stabilized two-part disinfecting system and compositions and methods related thereto
US6039934A (en) Use of xanthan gum for gelling CIO2 and related species
US4788060A (en) Multiple electrolyte douche and wipe composition
US4891216A (en) Disinfecting compositions and methods therefor
US4937066A (en) Zinc containing oral compositions
US3806593A (en) Hygienic-cosmetic compositions
US4923900A (en) Therapeutic compositions containing benzoyl peroxide
US5086075A (en) Therapeutic compositions containing benzoyl peroxide
US4317814A (en) Preparation and method for treating burns
CA2382569A1 (en) Super-oxidized water, preparation and use therefor as sterilizers and medicaments
KR20020009596A (en) Disinfecting composition based on h2o2, acids and metal ions
CN1688280B (en) Two-component composition containing antiplaque enzyme
US4844886A (en) Cosmetic compositions with a content of hydrogenperoxide and alpha-bisabolol as well as use of alpha-bisabolol for the stabilization of hydrogenperoxide
JPH03204805A (en) Skin drug for external use
US4203969A (en) Dithranol compositions for topical applications
US2361624A (en) Stabilized therapeutic agents
US5039515A (en) Mouth cleansing preparation
AU2001272452A1 (en) Preparation containing an oxygen carrier for regeneration of the skin in the case of oxygen deficiency
JPH0327532B2 (en)
DE2658424A1 (en) COLD PERMANENT WELLING AGENT
US5709851A (en) Pharmaceutical iodine compositions with reduced irritancy
JPS5869806A (en) Cosmetic lotion containing stable collagen
US4111653A (en) Alkali stannite depilatories
US6007827A (en) Method of depigmenting or bleaching mammalian skin using L-2-oxothiazolidine-4-carboxylic acid

Legal Events

Date Code Title Description
REMI Maintenance fee reminder mailed
LAPS Lapse for failure to pay maintenance fees
FP Lapsed due to failure to pay maintenance fee

Effective date: 19921101

STCH Information on status: patent discontinuation

Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362