US3992399A - 1,2,4-Triazolyl-phosphoric and -phosphonic acid esters - Google Patents

1,2,4-Triazolyl-phosphoric and -phosphonic acid esters Download PDF

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US3992399A
US3992399A US05/422,038 US42203873A US3992399A US 3992399 A US3992399 A US 3992399A US 42203873 A US42203873 A US 42203873A US 3992399 A US3992399 A US 3992399A
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Beat Bohner
Dag Dawes
Willy Meyer
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Novartis Corp
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Ciba Geigy Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings

Definitions

  • the present invention relates to 1,2,4-triazolylphosphoric and 1,2,4-triazolylphosphonic acid esters, to a process for their manufacture, and to their use in pest control.
  • the 1,2,4-triazolylphosphoric and 1,2,4-triazolylphosphonic acid esters have the formula ##SPC3##
  • R 1 represents hydrogen, alkyl, cycloalkyl, phenyl, benzyl, or phenethyl
  • R 2 represents substituted phenyl, benzyl, phenethyl, or unsubstituted diphenylmethyl, ⁇ -naphthyl, or ##SPC4##
  • R 3 represents alkyl, alkoxy, alkylthio, amino, monoalkylamino or dialkylamino
  • R 4 represents alkyl
  • X represents oxygen or sulphur.
  • alkyl, alkyloxy, alkylthio, a monoalkylamino or dialkylamino radical is meant in each case a straight-chain or branched unsubstituted radical with 1 to 12 carbon atoms, the alkyl radicals having from 2 to 12, preferably 1 to 6, carbon atoms.
  • radicals include: methyl, methoxy, methylthio, ethyl, ethoxy, ethylthio, propyl, propoxy, propylthio, isopropyl, isopropoxy, isopropylthio, n-butyl, iso-butyl, sec. and tert. butyl, n-pentyl, n-hexyl, and isomers thereof, n-pentylthio, methylamino, dimethylamino.
  • cycloalkyl radicals which are possible for R 1 contain from 3 to 8 ring carbon atoms.
  • Preferred cycloalkyl radicals are cyclopropyl, cyclopentyl, or cyclohexyl.
  • the phenyl, benzyl and phenethyl groups represented by R 1 can be unsubstituted at the rings or substituted e.g. by methoxy, halogen atoms, such as fluorine, chlorine, bromine and/or iodine, preferably chlorine, alkyl with 1 to 5 carbon atoms and/or haloalkyl with 1 to 5 carbon atoms.
  • halogen atoms such as fluorine, chlorine, bromine and/or iodine, preferably chlorine, alkyl with 1 to 5 carbon atoms and/or haloalkyl with 1 to 5 carbon atoms.
  • Examples of possible substituents at the phenyl, benzyl and phenethyl radicals represented by R 2 are one or more, similar or different, halogen atoms, such as fluorine, chlorine, bromine, and/or iodine and/or alkyl, alkoxy, alkylthio, haloalkyl, nitro, cyano, amino, monoalkylamino and dialkylamino, acetylamino, methylsulphonyl and/or carbamoyl groups.
  • halogen atoms such as fluorine, chlorine, bromine, and/or iodine and/or alkyl, alkoxy, alkylthio, haloalkyl, nitro, cyano, amino, monoalkylamino and dialkylamino, acetylamino, methylsulphonyl and/or carbamoyl groups.
  • Preferred compounds on account of their action are those of the formula I wherein R 1 represents hydrogen, alkyl with 1 to 6 carbon atoms, cyclopentyl, or unsubstituted phenyl, R 2 represents phenyl or benzyl which is mono- or polysubstituted in like manner or differently, by halogen, alkyl with 1 to 6 carbon atoms, methoxy, methylthio, methylsulphonyl, trifluoromethyl, acetylamino, carbamoyl, cyano and/or nitro, or represents unsubstituted diphenylmethyl, ⁇ -naphthyl or ##SPC5##
  • R 3 represents alkyl with 1 to 6 carbon atoms, alkoxy with 1 to 6 carbon atoms, alkylthio with 1 to 6 carbon atoms, amino, alkylamino or dialkylamino, each with 1 to 6 carbon atoms
  • R 4 represents alkyl with 1 to 6 carbon atoms
  • X represents oxygen or sulphur.
  • R 1 represents alkyl with 1 to 3 carbon atoms or cyclopentyl
  • R 2 represents benzyl which is mono- or polysubstituted by fluorine, chlorine, bromine, nitro, or methyl, or represents unsubstituted ##SPC6##
  • R 3 represents ethoxy or propylthio
  • R 4 represents ethyl
  • X represents sulphur
  • the compounds of the formula I can be manufactured by methods which are known per se, for example
  • Suitable acid acceptors are: tertiary amines, such as triethylamine, dimethyl aniline, pyridine, inorganic bases, such as hydroxides and carbonates of alkali metals and alkaline earth metals, preferably sodium and potassium carbonate.
  • the reactions can take place preferably in solvents or diluents which are inert towards the reactants.
  • solvents or diluents are: aromatic hydrocarbons, e.g. benzene, toluene, halogenated hydrocarbons, chlorobenzene, polychlorobenzenes, bromobenzene, chlorinated alkanes with 1 to 3 carbon atoms, ethers, e.g. dioxan, tetrahydrofuran, esters, e.g. ethyl acetate, ketones, e.g. acetone, methyl ethyl ketone, diethyl ketone, nitriles, e.g. acetonitrile etc.
  • the compounds of the formula I have a broad biocidal activity and can be used for combating a variety of plant and animal pests.
  • insecticides and/or acaricides it is possible to improve substantially the insecticidal or acaricidal action and do adapt it to given circumstances.
  • Suitable additives are: organic phosphorus compounds, nitrophenols and derivatives thereof; pyrethrines; formamidines; ureas; carbamates and chlorinated hydrocarbons.
  • the compounds of the formula I also exhibit a microbiocidal action.
  • a number of these compounds display bactericidal action. But they are active chiefly against fungi, especially against phytopathogenic fungi belonging to the following classes: Oomycetes, Zygomycetes, Ascomycetes, Basidiomycetes, Denteromycetes.
  • the compounds of the formula I also exhibit a fungitoxic action against fungi which attack the plants from the soil.
  • the new active substances are also suitable for treating seeds, fruit, tubers etc. from attack by fungus infections.
  • the compounds of the formula I are also suitable for combating phytopathogenic nematodes.
  • the compounds of the formula I may be used as pure active substance or together with suitable carriers and/or additives.
  • suitable carriers and additives can be solid or liquid and correspond to the substances conventionally used in formulation technology, for example natural or regenerated substances, solvents, dispersants, wetting agents, adhesives, thickeners, binders and/or fertilisers.
  • the compounds of the formula I may be processed to dusts, emulsion concentrates, granules, dispersions, sprays, to solutions or suspensions, in the conventional formulation which is commonly employed in application technology. Mention is also to be made of cattle dips and spray races, in which aqueous preparations are used.
  • the agents according to the invention are manufactured in known manner by intimately mixing and/or grinding active substances of the formula I with the suitable carriers, optionally with the addition of dispersants or solvents which are inert towards the active substances.
  • the active substances can take, and be used in, the following forms:
  • the content of active substance in the above described agents is between 0.1 to 95%, in which connection it should be mentioned that, in the case of application from aircraft or some other suitable means of application, it is possible to use concentrations of up to 99.5% or even pure active substance.
  • the active substances of the formula I can, for example, be formulated as follows:
  • the active substances are mixed with the carriers and ground.
  • the active substance is mixed with epichlorohydrin and dissolved with 6 parts of acetone; the polyethylene glycol and cetyl polyglycol ether are then added. The resulting solution is sprayed on kaolin, and the acetone is subsequently evaporated in vacuo.
  • the active substances are intimately mixed, in suitable mixers, with the additives, the mixture being then ground in the appropriate mills and rollers. Wettable powders are obtained which can be diluted with water to give suspensions of any desired concentration.
  • n D 20 1.5635.
  • Cotton and potato plants were sprayed with a 0.05% aqueous emulsion (obtained from a 10% emulsifiable concentrate). After the coating had dried, the cotton plants were populated with Spodoptera littoralis or Heliothis virescens larvae L 3 and the potato plants with Colorado potato bettle larvae (Leptinotarsa decemlineata). The test was carried outat 24° C and 60% relative humidity. In the above test, the compoundsaccording to Example 1 displayed good ingest poison action against Spodoptera littoralis. Heliothis and Leptinotarsa decemlineata larvae.
  • Tests were carried out in each case with 20 OP-sensitive larvae using a dilution series analogous to that of test A. (The resistance refers to thetolerability of Diazinon).
  • the compounds according to Example 1 acted in these tests against adults and larvae of Rhipicephalus bursa and sensitiveand OP-resistant larvae of Boophilus microplus.
  • Phaseolus vulgaris (dwarf beans) have an infested piece of leaf from a massculture of Tetranychus urticae placed on them 12 hours before the test for the acaricidal action.
  • the mobile stages which have migrated are sprayed with the emulsified test preparations from a chromatography atomiser so that the spray broth does not run off.
  • the number of living and dead larvae, adults and eggs are evaluated after 2 to 7 days under a stereoscopic microscope and the result expressed in percentages.
  • the treated plants are kept in greenhouse compartments at 25° C.
  • the compounds according to Example 1 were active in the above test against eggs, larvae and adults of Tetranychus urticae.
  • the active substance in the concentration indicated in each case is applied to an intimately mixed with soil infected with root gall nematodes (Meloidgyne arenaria).
  • tomato cuttings are planted in the thus prepared soil in a series of tests and after a waiting time of 8 days tomato seeds are sown in another test series.
  • Example 1 In order to assess the nematocidal action the galls present on the roots are counted 28 days after planting and sowing respectively. In this test the compounds according to Example 1 display good action against Meloidgyne arenaria.

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Abstract

1,2,4-Triazolylphosphoric and 1,2,4-triazolylphosphonic acid esters of the formula ##SPC1##
Wherein R1 represents hydrogen, alkyl, cycloalkyl, phenyl, benzyl, or phenethyl, R2 represents substituted phenyl, benzyl, phenethyl, or unsubstituted diphenylmethyl, β-naphthyl, or ##SPC2##
R3 represents alkyl, alkoxy, alkylthio, amino, monoalkylamino or dialkylamino, R4 represents alkyl, and X represents oxygen or sulphur, a process for their manufacture and their use in pest control.

Description

The present invention relates to 1,2,4-triazolylphosphoric and 1,2,4-triazolylphosphonic acid esters, to a process for their manufacture, and to their use in pest control. The 1,2,4-triazolylphosphoric and 1,2,4-triazolylphosphonic acid esters have the formula ##SPC3##
Wherein R1 represents hydrogen, alkyl, cycloalkyl, phenyl, benzyl, or phenethyl, R2 represents substituted phenyl, benzyl, phenethyl, or unsubstituted diphenylmethyl, β-naphthyl, or ##SPC4##
R3 represents alkyl, alkoxy, alkylthio, amino, monoalkylamino or dialkylamino, R4 represents alkyl, and X represents oxygen or sulphur.
By an alkyl, alkyloxy, alkylthio, a monoalkylamino or dialkylamino radical is meant in each case a straight-chain or branched unsubstituted radical with 1 to 12 carbon atoms, the alkyl radicals having from 2 to 12, preferably 1 to 6, carbon atoms.
Examples of such radicals include: methyl, methoxy, methylthio, ethyl, ethoxy, ethylthio, propyl, propoxy, propylthio, isopropyl, isopropoxy, isopropylthio, n-butyl, iso-butyl, sec. and tert. butyl, n-pentyl, n-hexyl, and isomers thereof, n-pentylthio, methylamino, dimethylamino.
The cycloalkyl radicals which are possible for R1 contain from 3 to 8 ring carbon atoms. Preferred cycloalkyl radicals are cyclopropyl, cyclopentyl, or cyclohexyl.
The phenyl, benzyl and phenethyl groups represented by R1 can be unsubstituted at the rings or substituted e.g. by methoxy, halogen atoms, such as fluorine, chlorine, bromine and/or iodine, preferably chlorine, alkyl with 1 to 5 carbon atoms and/or haloalkyl with 1 to 5 carbon atoms.
Examples of possible substituents at the phenyl, benzyl and phenethyl radicals represented by R2 are one or more, similar or different, halogen atoms, such as fluorine, chlorine, bromine, and/or iodine and/or alkyl, alkoxy, alkylthio, haloalkyl, nitro, cyano, amino, monoalkylamino and dialkylamino, acetylamino, methylsulphonyl and/or carbamoyl groups.
Preferred compounds on account of their action are those of the formula I wherein R1 represents hydrogen, alkyl with 1 to 6 carbon atoms, cyclopentyl, or unsubstituted phenyl, R2 represents phenyl or benzyl which is mono- or polysubstituted in like manner or differently, by halogen, alkyl with 1 to 6 carbon atoms, methoxy, methylthio, methylsulphonyl, trifluoromethyl, acetylamino, carbamoyl, cyano and/or nitro, or represents unsubstituted diphenylmethyl, β-naphthyl or ##SPC5##
R3 represents alkyl with 1 to 6 carbon atoms, alkoxy with 1 to 6 carbon atoms, alkylthio with 1 to 6 carbon atoms, amino, alkylamino or dialkylamino, each with 1 to 6 carbon atoms, R4 represents alkyl with 1 to 6 carbon atoms, and X represents oxygen or sulphur.
Particularly preferred compounds, however, are those of the formula I wherein R1 represents alkyl with 1 to 3 carbon atoms or cyclopentyl, R2 represents benzyl which is mono- or polysubstituted by fluorine, chlorine, bromine, nitro, or methyl, or represents unsubstituted ##SPC6##
or diphenylmethyl, R3 represents ethoxy or propylthio, R4 represents ethyl, and X represents sulphur.
The compounds of the formula I can be manufactured by methods which are known per se, for example
a. by reacting a hydroxy-triazole of the formula ##SPC7##
in the presence of an acid acceptor with a compound of the formula ##STR1## or
b. by reacting a hydroxy-triazole of the formula ##SPC8##
with a compound of the formula ##STR2## or
c. by reacting a hydroxy-triazole of the formula ##SPC9##
with a compound of the formula
R.sub.4 -- O -- PX -- Cl.sub.2                             (V)
and subsequently reacting the intermediate product of the formula ##SPC10##
with the compound of the formula
HN(Alkyl).sub.2                                            (VII) ##STR3## wherein R.sub.1 to R.sub.4 and X have the meanings given for the formula I, Hal represents a halogen atom, in particular chlorine or bromine, and Me represents a monovalent metal, especially an alkali metal.
Examples of suitable acid acceptors are: tertiary amines, such as triethylamine, dimethyl aniline, pyridine, inorganic bases, such as hydroxides and carbonates of alkali metals and alkaline earth metals, preferably sodium and potassium carbonate.
The reactions can take place preferably in solvents or diluents which are inert towards the reactants. Suitable examples of such solvents or diluents are: aromatic hydrocarbons, e.g. benzene, toluene, halogenated hydrocarbons, chlorobenzene, polychlorobenzenes, bromobenzene, chlorinated alkanes with 1 to 3 carbon atoms, ethers, e.g. dioxan, tetrahydrofuran, esters, e.g. ethyl acetate, ketones, e.g. acetone, methyl ethyl ketone, diethyl ketone, nitriles, e.g. acetonitrile etc.
Starting materials of the formulae II and IV are new and can be synthesised in analogous manner to the method described in Belgian patent No. 792,449. It is also possible to manufacture the starting materials by reacting a 5-halo-3-hydroxy-1,2,4-triazole derivative with metal salts of corresponding mercaptans.
The compounds of the formula I have a broad biocidal activity and can be used for combating a variety of plant and animal pests.
In particular they are suitable for combating insects of the families:
Blattidae, Gryllidae, Gryllotalpidae, Tettigoniidae, Cimicidae, Phyrrhocoridae, Reduviidae, Aphididae, Delphacidae, Diaspididae, Pseudococcidae, Chrysomelidae, Coccinellidae, Bruchidae, Scarabaeidae, Dermestidae, Tenebrionidae, Curculinoidae, Tineidae, Noctuidae, Lymantriidae, Paralidae, Galleriidae, Culicidae, Tipulidae, Stomoxydae, Muscidae, Calliphoridae, Trypetidae, Pulicidae, as well as Acaridae of the families: Ixodidae, Argasidae, Tetranychidae, Dermanyssidae.
By addition of other insecticides and/or acaricides it is possible to improve substantially the insecticidal or acaricidal action and do adapt it to given circumstances.
Examples of suitable additives are: organic phosphorus compounds, nitrophenols and derivatives thereof; pyrethrines; formamidines; ureas; carbamates and chlorinated hydrocarbons.
In addition to the above mentioned properties, the compounds of the formula I also exhibit a microbiocidal action. Thus a number of these compounds display bactericidal action. But they are active chiefly against fungi, especially against phytopathogenic fungi belonging to the following classes: Oomycetes, Zygomycetes, Ascomycetes, Basidiomycetes, Denteromycetes.
The compounds of the formula I also exhibit a fungitoxic action against fungi which attack the plants from the soil. The new active substances are also suitable for treating seeds, fruit, tubers etc. from attack by fungus infections. The compounds of the formula I are also suitable for combating phytopathogenic nematodes.
The compounds of the formula I may be used as pure active substance or together with suitable carriers and/or additives. Suitable carriers and additives can be solid or liquid and correspond to the substances conventionally used in formulation technology, for example natural or regenerated substances, solvents, dispersants, wetting agents, adhesives, thickeners, binders and/or fertilisers.
For application, the compounds of the formula I may be processed to dusts, emulsion concentrates, granules, dispersions, sprays, to solutions or suspensions, in the conventional formulation which is commonly employed in application technology. Mention is also to be made of cattle dips and spray races, in which aqueous preparations are used.
The agents according to the invention are manufactured in known manner by intimately mixing and/or grinding active substances of the formula I with the suitable carriers, optionally with the addition of dispersants or solvents which are inert towards the active substances. The active substances can take, and be used in, the following forms:
Solid forms:
dusts, tracking agents, granules, coated granules, impregnated granules and homogeneous granules.
Liquid forms:
a. active substances which are dispersible in water: wettable powders, pasts, emulsions:
b. solutions.
The content of active substance in the above described agents is between 0.1 to 95%, in which connection it should be mentioned that, in the case of application from aircraft or some other suitable means of application, it is possible to use concentrations of up to 99.5% or even pure active substance.
The active substances of the formula I can, for example, be formulated as follows:
Dusts
The following substances are used to manufacture (a) a 5% and (b) a 2% dust:
a.
5 parts of active substance
95 parts of talcum
b.
2 parts of active substance
1 part of highly disperse silicic acid
97 parts of talcum.
The active substances are mixed with the carriers and ground.
Granules
The following substances are used to produce 5% granules:
5 parts of active substance,
0.25 parts of epichlorohydrin,
0.25 parts of cetyl polyglycol ether,
3.50 parts of polyethylene glycol,
91 parts of kaolin (particle size 0.3-0.8 mm).
The active substance is mixed with epichlorohydrin and dissolved with 6 parts of acetone; the polyethylene glycol and cetyl polyglycol ether are then added. The resulting solution is sprayed on kaolin, and the acetone is subsequently evaporated in vacuo.
Wettable powder
The following constituents are used for the preparation of (a) a 40% (b) and (c) a 25% and (d) a 10% wettable powder:
a.
40 parts of active substance,
5 parts of sodium lignin sulphonate,
1 part of sodium dibutyl-naphthalene sulphonate,
54 parts of silicic acid.
b.
25 parts of active substance,
4.5 parts of calcium lignin sulphonate,
1.9 parts of Champagne chalk/hydroxyethyl cellulose mixture (1:1),
1.5 parts of sodium dibutyl naphthalene sulphonate,
19.5 parts of silicic acid,
19.5 parts of Champagne chalk,
28.1 parts of kaolin.
c.
25 parts of active substance,
2.5 parts of isooctylphenoxy-polyoxyethyleneethanol,
1.7 parts of Champagne chalk/hydroxyethyl cellulose mixture (1:1),
8.3 parts of sodium aluminium silicate,
16.6 parts of kieselguhr,
46 parts of kaolin.
d.
10 parts of active substance,
3 parts of a mixture of the sodium salts of saturated fatty alcohol sulphates,
5 parts of naphthalenesulphonic acid/formaldehyde condensate,
82 parts of kaolin.
The active substances are intimately mixed, in suitable mixers, with the additives, the mixture being then ground in the appropriate mills and rollers. Wettable powders are obtained which can be diluted with water to give suspensions of any desired concentration.
Emulsifiable concentrates
The following substances are used to produce (a) a 10% and (b) a 25% emulsifiable concentrate:
a.
10 parts of active substance,
3.4 parts of epoxidised vegetable oil,
13.4 parts of a combination emulsifier consisting of fatty alcohol polyglycol ether and alkylaryl sulphonate calcium salt,
40 parts of dimethylformamide,
43.2 parts of xylene,
25 parts of active substance,
2.5 parts of epoxidised vegetable oil,
10 parts of an alkylarylsulphonate/fatty alcoholglycol ether mixture,
5 parts of dimethylformamide,
57.5 parts of xylene.
From these concentrates it is possible to produce, by dilution with water, emulsions of any desired concentration.
Spray
The following constituents are used to prepared a 5% spray:
5 parts of active substance,
1 part of epichlorohydrin,
94 parts of benzene (boiling limits 160°-190° C).
EXAMPLE 1 A. Manufacture of the starting materials
1-methyl-3-hydroxy-5-(2,6-dinitro-4-trifluoromethylphenyl)-mercapto-1,2,4-triazole
11.1 g of triethylamino are added to a suspension of 13.1 g of 1-methyl-3-hydroxy-5-mercapto-1,2,4-triazole and 29.8 g of 4-chloro-3,5-dinitrobenzotrifluoride in 100 ml of ethanol. An exothermic reaction commences. The reaction mixture is stirred for 30 minutes and thedark coloured solution is then allowed to cool. The precipitate is filteredoff to yield, after purification with abundant water, the compound is the formula ##SPC11##
with a melting point of 187° C.
______________________________________                                    
Analysis:     found:       calculated:                                    
______________________________________                                    
            C 33.1 %   32.90 %                                            
            H  1.7 %    1.65 %                                            
            F 15.9 %   15.60 %                                            
            N 19.0 %   19.17 %                                            
______________________________________
1-methyl-3-hydroxy-5-(2,6-dichlorobenzyl)mercapto-1,2,4-triazole
11.1 g of triethylamine are added at room temperature to a suspension of 13.1 g of 1-methyl-3-hydroxy-5-mercaptotriazole and 27.4 g of 2,6-dichlorobenzyl chloride in 100 ml of ethanol. The exothermic reaction causes the temperature to rise to about 45° C. The clear solution is then stirred for 30 minutes and evaporated to dryness. The solid residue is treated with abundant water and the undissolved material is filtered off. It is recrystallised from methanol/acetone.
______________________________________                                    
Analysis:                                                                 
         found:      calculated:                                          
                                m.p. 209° C                        
______________________________________                                    
       C 41.5 %  41.39 %                                                  
       H  3.2 %   3.13 %                                                  
       N 14.2 %  14.48 %                                                  
       Cl 24.1 % 24.44 %                                                  
______________________________________
1-isopropyl-5-(p)-chlorophenylmercapto-3-hydroxy-1,2,4-triazole
145 g of p-chlorothiophenol, 80 g of sodium hydroxide, and 161.5 g of i-isopropyl-5-chloro-3-hydroxy-1,2,4-triazole in 200 ml of water are refluxed for 15 hours. After it has cooled, the solution is acidified withacetic acid, then left to stand for 12 hours. The precipitated crystalline product is collected by suction filtration, the filter product washed witha small amount of water, and dried in vacuo. It is then subsequently recrystallised from acetonitrile.
______________________________________                                    
Analysis:     found:        calculated:                                   
______________________________________                                    
            C 48.5 %    49.0 %                                            
            H  4.7 %     4.5 %                                            
            Cl 13.6 %   13.2 %                                            
            N 15.2 %    15.6 %                                            
            S 12.0 %    11.9 %                                            
______________________________________
The following compounds are manufactured in analogous manner: ##SPC12##
It is also possible to manufacture the following compounds in analogous manner: ##SPC13##
B. Manufacture of the new active substances O-O-diethyl-O-(1-methyl-5-2',6'-dichlorobenzylthio-1,2,4-triazolyl-(3)-thiophosphoric acidester
29.0 g of 1-methyl-5-2',6'-dichlorobenzylthio-3-hydroxy-1,2,4-triazole and 13.8 g of potassium carbonate are refluxed for 2 hours in 500 ml of methylethyl ketone. The reaction mixture is cooled to 35° C and 19.0 g of diethylthiophosphoric chloride are added dropwise over the course of 15 minutes. The batch is refluxed once more for 11/2 hours and subsequently stirred overnight at room temperature. The insoluble salts are filtered off and the methyl ethyl ketone is distilled off in vacuo. The oily residue is purified by chromatography over a silica gel column with methylene chloride as eluant. The methylene chloride is distilled off in vacuo to yield 35.1 g of an oily product of the formula ##SPC14##
with a refractive index of nD 20 = 1.5635.
The following compounds were manufactured in analogous manner:
__________________________________________________________________________
 ##STR4##                                                                 
                                     Physical                             
R.sub.1                                                                   
       R.sub.2      X    R.sub.3                                          
                                R.sub.4                                   
                                     data                                 
__________________________________________________________________________
 CH.sub.3                                                                 
        ##STR5##     S   OC.sub.2 H.sub.5                                 
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1,5569              
 CH.sub.3                                                                 
        ##STR6##     S   SC.sub.3 H.sub.7 (n)                             
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1.5750              
 CH.sub.3                                                                 
        ##STR7##     S   OC.sub.2 H.sub.5                                 
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1,5616              
 CH.sub.3                                                                 
        ##STR8##     S   OC.sub.2 H.sub.5                                 
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1,5593              
 CH.sub.3                                                                 
        ##STR9##     S   OC.sub.2 H.sub.3                                 
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1,5689              
 CH.sub.3                                                                 
        ##STR10##    S   OC.sub.2 H.sub.5                                 
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1,5426              
 CH.sub.3                                                                 
        ##STR11##    S   OC.sub.2 H.sub.5                                 
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1,5475              
 CH.sub.3                                                                 
        ##STR12##    S   OC.sub.2 H.sub.5                                 
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1,5500              
 CH.sub.3                                                                 
        ##STR13##     S  OC.sub.2 H.sub.5                                 
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1,5636              
 CH.sub.3                                                                 
        ##STR14##    S   OC.sub.2 H.sub.5                                 
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1,5681              
 CH.sub.3                                                                 
        ##STR15##    S   OC.sub.2 H.sub.5                                 
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1,5393              
 CH.sub.3                                                                 
        ##STR16##    S   OC.sub.2 H.sub.5                                 
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1,5424              
 CH.sub.3                                                                 
        ##STR17##    S   OC.sub.2 H.sub.5                                 
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1,5635              
 CH.sub.3                                                                 
        ##STR18##    S   OC.sub.2 H.sub.5                                 
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1,5778              
  C.sub.2 H.sub.5                                                         
        ##STR19##    S   OC.sub.2 H.sub.5                                 
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1,5523              
 (i)C.sub.3 H.sub.7                                                       
        ##STR20##    S   OC.sub.2 H.sub.5                                 
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1,5446              
 ##STR21##                                                                
        ##STR22##    S   OC.sub.2 H.sub.5                                 
                                C.sub.2 H.sub.5                           
                                     n.sub.D.sup.20 = 1,5557              
__________________________________________________________________________
It is also possible to manufacture in analogous manner:
__________________________________________________________________________
 ##STR23##                                                                
                                      Physical                            
R.sub.1                                                                   
      R.sub.2     X    R.sub.3  R.sub.4                                   
                                      data                                
__________________________________________________________________________
 CH.sub.3                                                                 
       ##STR24##   S   C.sub.2 H.sub.5                                    
                                C.sub.2 H.sub.5                           
 CH.sub.3                                                                 
       ##STR25##   S   CH.sub.3                                           
                                C.sub.2 H.sub.5                           
 CH.sub.3                                                                 
       ##STR26##   S   CH.sub.3                                           
                                C.sub.3 H.sub.7 (n)                       
 CH.sub.3                                                                 
       ##STR27##   S   NHCH.sub.3                                         
                                C.sub.2 H.sub.5                           
 CH.sub.3                                                                 
       ##STR28##   S   NHC.sub.3 H.sub.7 (i)                              
                                C.sub.2 H.sub.5                           
 CH.sub.3                                                                 
       ##STR29##   O   SC.sub.3 H.sub.7 (n)                               
                                C.sub.2 H.sub.5                           
 CH.sub.3                                                                 
       ##STR30##   S   NHC.sub.2 H.sub.5                                  
                                C.sub.2 H.sub.5                           
 CH.sub.3                                                                 
       ##STR31##   S   OCH.sub.3                                          
                                CH.sub.3                                  
 CH.sub.3                                                                 
       ##STR32##   S   NH.sub.2                                           
                                C.sub.2 H.sub.5                           
 CH.sub.3                                                                 
       ##STR33##   S   N(CH.sub.3).sub.2                                  
                                C.sub.2 H.sub.5                           
 CH.sub.3                                                                 
       ##STR34##   O   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 CH.sub.3                                                                 
       ##STR35##   S   OCH.sub.3                                          
                                CH.sub.3                                  
 CH.sub.3                                                                 
       ##STR36##   S   SC.sub.3 H.sub.7 (n)                               
                                C.sub.2 H.sub.5                           
 CH.sub.3                                                                 
       ##STR37##   S   C.sub.2 H.sub.5                                    
                                C.sub.2 H.sub.5                           
 CH.sub.3                                                                 
       ##STR38##   S   NHC.sub.3 H.sub.7 (n)                              
                                C.sub.2 H.sub.5                           
 CH.sub.3                                                                 
       ##STR39##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 CH.sub.3                                                                 
       ##STR40##   S   OCH.sub.3                                          
                                CH.sub.3                                  
 CH.sub.3                                                                 
       ##STR41##   S    OC.sub.2 H.sub.5                                  
                                C.sub.2 H.sub.5                           
 CH.sub.3                                                                 
       ##STR42##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 CH.sub.3                                                                 
       ##STR43##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 H                                                                        
       ##STR44##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 H                                                                        
       ##STR45##   S   OCH.sub.3                                          
                                CH.sub.3                                  
 H                                                                        
       ##STR46##   S   SC.sub.3 H.sub.7                                   
                                C.sub.2 H.sub.5                           
 H                                                                        
       ##STR47##   S   C.sub.2 H.sub.5                                    
                                C.sub.2 H.sub.5                           
 H                                                                        
       ##STR48##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 H                                                                        
       ##STR49##   S   NHCH.sub.3                                         
                                C.sub.2 H.sub.5                           
 H                                                                        
       ##STR50##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 H                                                                        
       ##STR51##   S   OCH.sub.3                                          
                                CH.sub.3                                  
 H                                                                        
       ##STR52##   O   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 H                                                                        
       ##STR53##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 H                                                                        
       ##STR54##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 H                                                                        
       ##STR55##   S   OC.sub.2 H.sub. 5                                  
                                C.sub.2 H.sub.5                           
 H                                                                        
       ##STR56##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 H                                                                        
       ##STR57##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 H                                                                        
       ##STR58##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 H                                                                        
       ##STR59##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 H                                                                        
       ##STR60##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 C.sub.2 H.sub.5                                                          
       ##STR61##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 C.sub.3 H.sub.7                                                          
       ##STR62##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 (i)C.sub.3 H.sub.7                                                       
       ##STR63##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 (i)C.sub.3 H.sub.7                                                       
       ##STR64##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 ##STR65##                                                                
       ##STR66##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 ##STR67##                                                                
       ##STR68##   S   OCH.sub.3                                          
                                CH.sub.3                                  
 ##STR69##                                                                
       ##STR70##   S   C.sub.2 H.sub.5                                    
                                C.sub.2 H.sub.5                           
 ##STR71##                                                                
       ##STR72##   S   NH.sub.2                                           
                                C.sub.2 H.sub.5                           
 ##STR73##                                                                
       ##STR74##   S   NHCH.sub.3                                         
                                C.sub.2 H.sub.5                           
 ##STR75##                                                                
       ##STR76##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 ##STR77##                                                                
       ##STR78##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
 ##STR79##                                                                
       ##STR80##   S   OC.sub.2 H.sub.5                                   
                                C.sub.2 H.sub.5                           
__________________________________________________________________________
EXAMPLE 2 A. Insecticidal ingest poison action
Cotton and potato plants were sprayed with a 0.05% aqueous emulsion (obtained from a 10% emulsifiable concentrate). After the coating had dried, the cotton plants were populated with Spodoptera littoralis or Heliothis virescens larvae L3 and the potato plants with Colorado potato bettle larvae (Leptinotarsa decemlineata). The test was carried outat 24° C and 60% relative humidity. In the above test, the compoundsaccording to Example 1 displayed good ingest poison action against Spodoptera littoralis. Heliothis and Leptinotarsa decemlineata larvae.
EXAMPLE 3 Action against Chilo suppressalis
Six rice plants at a time of the variety Caloro were transplanted into plastic pots (diameter at the top = 17 cm) and reared to a height of about60 cm. Infestation with Chilo suppressalis larvae (L.sub. 1 : 3-4 mm long) took place 2 days after the active substance had been applied in granule form to the paddy water (rate of application: 8 kg of active substance perhectare). Evaluation of the insecticidal action took place 10 days after application of the granules. The compounds according to Example 1 were active in the above test against Chilo suppressalis.
EXAMPLE 4 Action against ticks
A. rhipicephalus bursa
Five adult ticks and 50 tick larvae were counted into a glass tube and immersed for 1 to 2 minutes in 2 ml of an aqueous emulsion from an emulsion series each containing 100, 10, 1 or 0.1 ppm of test substance. The tube was then sealed with a standardised cotton wool plug and placed on its head, so that the active substance emulsion could be absorbed by the cotton wool.
In the case of the adults evaluation took place after 2 weeks, and in that of the larvae after 2 days. Each test was repeated twice.
B. boophilus microplus (larvae)
Tests were carried out in each case with 20 OP-sensitive larvae using a dilution series analogous to that of test A. (The resistance refers to thetolerability of Diazinon). The compounds according to Example 1 acted in these tests against adults and larvae of Rhipicephalus bursa and sensitiveand OP-resistant larvae of Boophilus microplus.
EXAMPLE 5 Acaricidal action
Phaseolus vulgaris (dwarf beans) have an infested piece of leaf from a massculture of Tetranychus urticae placed on them 12 hours before the test for the acaricidal action. The mobile stages which have migrated are sprayed with the emulsified test preparations from a chromatography atomiser so that the spray broth does not run off. The number of living and dead larvae, adults and eggs are evaluated after 2 to 7 days under a stereoscopic microscope and the result expressed in percentages. During the "interim", the treated plants are kept in greenhouse compartments at 25° C. The compounds according to Example 1 were active in the above test against eggs, larvae and adults of Tetranychus urticae.
EXAMPLE 6 Action against soil nematodes
To the test action against soil nematodes, the active substance in the concentration indicated in each case is applied to an intimately mixed with soil infected with root gall nematodes (Meloidgyne arenaria). Immediately afterwards, tomato cuttings are planted in the thus prepared soil in a series of tests and after a waiting time of 8 days tomato seeds are sown in another test series.
In order to assess the nematocidal action the galls present on the roots are counted 28 days after planting and sowing respectively. In this test the compounds according to Example 1 display good action against Meloidgyne arenaria.

Claims (19)

We claim:
1. A compound of the formula ##SPC15##
wherein R1 represents alkyl with 1 to 3 carbon atoms or cyclopentyl; R2 represents diphenylmethyl, represents benzyl in which the phenyl group is substituted by one fluoro, bromo, nitro or up to three chloro radicals, or represents ##SPC16##
and R3 represents ethoxy or propylthio.
2. A compound according to claim 1, of the formula ##SPC17##
3. A compound according to claim 1, of the formula ##SPC18##
4. A compound according to claim 1, of the formula ##SPC19##
5. A compound according to claim 1, of the formula ##SPC20##
6. A compound according to claim 1, of the formula ##SPC21##
7. A compound according to claim 1, of the formula ##SPC22##
8. A compound according to claim 1, of the formula ##SPC23##
9. A compound according to claim 1, of the formula ##SPC24##
10. A compound according to claim 1, of the formula ##SPC25##
11. A compound according to claim 1, of the formula ##SPC26##
12. A compound according to claim 1, of the formula ##SPC27##
13. A compound according to claim 1, of the formula ##SPC28##
14. A compound according to claim 1, of the formula ##SPC29##
15. A compound according to claim 1, of the formula ##SPC30##
16. A compound according to claim 1, of the formula ##SPC31##
17. A compound according to claim 1, of the formula ##SPC32##
18. A compound according to claim 1, of the formula ##SPC33##
19. A compound according to claim 1, of the formula ##SPC34##
US05/422,038 1972-12-08 1973-12-05 1,2,4-Triazolyl-phosphoric and -phosphonic acid esters Expired - Lifetime US3992399A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH17896/72 1972-12-08
CH1789672A CH571818A5 (en) 1972-12-08 1972-12-08 O-Triazolyl O-alkyl (thio)phosph(on)ates - with biocidal (esp insecticidal and acaricidal)activity
CH15458/73 1973-11-02
CH1545873 1973-11-02

Publications (1)

Publication Number Publication Date
US3992399A true US3992399A (en) 1976-11-16

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ID=25716477

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Country Status (7)

Country Link
US (1) US3992399A (en)
JP (1) JPS5046840A (en)
BE (1) BE808382A (en)
DE (1) DE2360687A1 (en)
FR (1) FR2209766B1 (en)
IL (1) IL43739A (en)
NL (1) NL7316469A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4067970A (en) * 1975-10-14 1978-01-10 Bayer Aktiengesellschaft Pesticidal O-ethyl-S-n-propyl-O[pyrazolo(1,5-a)-pyrimidin-(2) yl]-thionothiolphosphoric acid esters
US4451653A (en) * 1981-05-04 1984-05-29 The Dow Chemical Company Heterocyclic substituted triazolyl phosphorous compounds
US4796435A (en) * 1986-04-28 1989-01-10 Omaha Cold Storage Terminals, Inc. By-products chiller and method for using same

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH601266A5 (en) * 1974-08-29 1978-06-30 Ciba Geigy Ag
FR3140022B1 (en) 2022-09-27 2024-08-09 Psa Automobiles Sa METHOD FOR DISTRIBUTING A TORQUE BETWEEN A FIRST AND A SECOND GEARBOX OF A VEHICLE

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3689500A (en) * 1969-11-21 1972-09-05 Ciba Geigy Corp O,O-DIETHYL-O-{8 1-METHYL-3-PHENYL-s-TRIAZOLYL-(5){9 {0 PHOSPHOROTHIOATE

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3689500A (en) * 1969-11-21 1972-09-05 Ciba Geigy Corp O,O-DIETHYL-O-{8 1-METHYL-3-PHENYL-s-TRIAZOLYL-(5){9 {0 PHOSPHOROTHIOATE

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4067970A (en) * 1975-10-14 1978-01-10 Bayer Aktiengesellschaft Pesticidal O-ethyl-S-n-propyl-O[pyrazolo(1,5-a)-pyrimidin-(2) yl]-thionothiolphosphoric acid esters
US4451653A (en) * 1981-05-04 1984-05-29 The Dow Chemical Company Heterocyclic substituted triazolyl phosphorous compounds
US4796435A (en) * 1986-04-28 1989-01-10 Omaha Cold Storage Terminals, Inc. By-products chiller and method for using same

Also Published As

Publication number Publication date
JPS5046840A (en) 1975-04-25
FR2209766A1 (en) 1974-07-05
IL43739A (en) 1976-12-31
IL43739A0 (en) 1974-03-14
DE2360687A1 (en) 1974-06-12
FR2209766B1 (en) 1978-11-10
BE808382A (en) 1974-06-07
NL7316469A (en) 1974-06-11

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