US3921864A - Syringes for making precision volume measurements - Google Patents

Syringes for making precision volume measurements Download PDF

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Publication number
US3921864A
US3921864A US399344A US39934473A US3921864A US 3921864 A US3921864 A US 3921864A US 399344 A US399344 A US 399344A US 39934473 A US39934473 A US 39934473A US 3921864 A US3921864 A US 3921864A
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United States
Prior art keywords
needle
bore
plunger
barrel
syringe
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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US399344A
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English (en)
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Ernest Fredrick Dawes
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Individual
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/344—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub using additional parts, e.g. clamping rings or collets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31555—Mechanically operated dose setting member by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31591—Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A61M5/31531—Microsyringes, e.g. having piston bore diameter close or equal to needle shaft diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw

Definitions

  • ABSTRACT A syringe comprising a barrel. :1 main bore in the bar rel opening at one end thereof. a needle receiving bore in the other end of the barrel substantially coaxiai with the main bore and communicating therewith a hollow needle removably engaged in the needle receiving bore a syringe plunger extending through the main bore and the needle receiving bore to precisely engage within the hollow needle, sealing means in said needle receiving bore and including a resilient seal through which the plunger slidably moves and means holding the needle in the needle receiving bore with the inner end of the needle in sealing engagement with said resilient seal.
  • measuring syringes have been developed to inject minute samples in gas chromatography, for delicate medical injections, in treatment of animals, and for a number of uses in laboratory work.
  • Such syringes may have a maximum capacity of ten microliters although syringes of this type are known with much larger and much smaller capacities.
  • These syringes are generally formed with an axially bored cylindrical glass barrel having a needle at one end and a plunger within the barrel for injecting material therein through the needle.
  • the barrel is provided with graduations for accurate measurement of injected amounts.
  • Syringes have been proposed with removable needles whereby a needle which has become bent or blocked through use may be quickly and simply replaced.
  • syringes fitted with replaceable needles have generally been unsuitable for use in applications involving injections under a high pressure in view of the difficulties of maintaining a seal between the needle and the barrel.
  • a still further object of the invention is to provide an improved construction of syringe having means to facilitate multiple delivery of identical quantities of liquid.
  • a still further object of the invention is to provide a syringe having an improved construction of needle to facilitate insertion of the needle into a septum, or the like, without damage thereto.
  • a syringe comprising a barrel, a main bore in the barrel opening at one end therof, a needle receiving bore in the other end of the barrel substantially coaxial with the main bore and communicating therewith, a hollow needle removably engaged in the needle receiving bore.
  • a syringe plunger extending through the main bore and the needle receiving bore to precisely engage within the hollow needle, sealing means in said needle receiving bore and including a resilient seal through which the plunger slidably moves, and means holding the needle in the needle receiving bore with the inner end of the needle in sealing engagement with said resilient seal.
  • the means holding the needle comprises a threaded boss on the end of the bar-- rel, an internally threaded nut engaged with the boss, the nut having an aperture through which the needle extends, shoulder means on the needle and resilient means acting between the nut and the shoulder means to resiliently urge the needle into sealing engagement with the seal.
  • the plunger which has a relatively small diameter (the total capacity of the syringe may be only 0.5 microliters and the plunger may have an axial movement of about 3 centimeters is preferably supported and guided in its axial movement through the barrel by a support tube secured in the barrel.
  • the support tube acts to prevent bending and kinking of the fine plunger.
  • a further outer tube or sleeve may be axially movable in the main bore of the barrel to provide a visual indication. in conjunction with graduations marked on the barrel surface, of the volume of the syringe at any position of the plunger. Further, this outer tube or sleeve engages with the inner end of the bore to limit inward movement of the plunger at the zero end of the plunger movement.
  • the seal is preferably formed of an unsintered polytetrafluoroethylene which, under the action of the resilient means holding the needle against the seal, l'lows to seal against the end of the needle, the barrel and the plunger.
  • the pressure constantly applied to the seal ensures that continued operation of the syringe plunger does not result in gradual development of leakages.
  • the needle diameter is relatively large.
  • the invention provides a needle having an entering end, or probiscus, of reduced diameter.
  • the probiscus has a relatively small diameter bore which reduces the likelihood of damaging membranes, septums and the like during insertion of the needle.
  • the invention also provides a syringe comprising a barrel, a bore in the barrel opening at one end thereof, a needle engaged in the other end of the barrel and communicating with the bore, a plunger slidably mounted in the bore, an operating button on the outer end of the plunger, an annular resilient sealing member disposed between the barrel and a sealing surface on the needle, fastening means on the barrel and engaged with the needle to hold the needle in sealing engagement with the seal, and a repetitive delivery assembly on the barrel and connected to the plunger.
  • the assembly including a member adjustably clamped to the outer surface of the barrel, elongated rod means extending through a hole in the member parallel with the axis of the bore, means connecting the outer end of the rod means to the plunger for axial movement therewith, and shoulder on the other end of the rod means engageable with the member to limit outward move ment of the plunger.
  • the repetitive delivery assembly enables repeated operations of the syringe to deliver in each operation an identical volume of fluid without the necessity of relying on a visual indication each time.
  • FIG. 1 is a cross sectional side elevational view of a syringe according to the present invention
  • FIG. 2 is a cross-sectional view of a modified form of syringe
  • FIG. 3 shows a further modified form of syringe
  • FIG. 4 is a detailed sectional view showing an alternative construction of needle for use with a syringe of the invention.
  • the syringe indicated generally at 11, comprises a cylindrical glass barrel 12 having an axial bore 13 open at one end 14 of the barrel ]2.
  • the other end of the bore 13 communicates with bore 16 of lesser diameter than the bore 13, the bore 16 being open at the opposite end 17 of the barrel 12.
  • the end 17 of the barrel [2 is of reduced outer diameter and a threaded boss 18 is secured thereon.
  • a plunger guide tube 21 is secured in the bore 16 and extends towards the end 14 substantially coaxially of the bore 13.
  • the end of the plunger guide tube in the bore 16 forms a shoulder 22 for the end of a needle 23 engaged in the bore l6.
  • the needle 23 has a shoulder 26 secured thereto and a nut 27 adapted to engage on the boss 18 compresses a spring 28 against the shoulder 26 to resiliently secure the needle 23 in the bore 16.
  • a plunger 31 extends from a finger piece 32 to slidably engage in the plunger guide tube 21.
  • the plunger 31 and plunger guide tube 21 are constrained to a coaxial position relative to the bore 13 by a supporting tube 33 secured to the finger piece 32.
  • the free end of the supporting tube 33 is also arranged to engage the end of the bore 13 to limit inward movement of the plunger. Further. the barrel 12 may be provided with graduations and the movement of the end of the tube 33 gives a visual indication of the plunger movement and contents of the syringe.
  • the plunger 31 extends into the needle bore 34 which forms the barrel therefor. Extremely close toler' ances are provided between the plunger 31 and the needle bore 34 to ensure the maximum possible accuracy in liquid delivery.
  • the seal 20 is preferably formed of polytetrafluoroethylene either sintered or unsintered and it is compressed between the respective parts by the compression spring 28 acting on the needle. The resilience of the seal results in complete sealing against the plunger surface and against the wall of the bore 16 as well as against the end of the needle 23.
  • FIG. 2 there is illustrated a modification of the construction of syringe shown in FIG. 1.
  • the diameter of the plunger 31 is relatively less than that of FIG. I. To avoid having.
  • the plunger guide 36 extending from the finger piece (not shown) is of larger diameter to obviate any tendency to bend or kink.
  • the guide 36 tapers down into the plunger 31 which extends into the needle as previously described.
  • the plunger guide tube 21 is of a diameter to receive the plunger guide 36.
  • the plunger guide 36 may be formed by securing a tube by one end thereof to the plunger 31, the tube having an internal diameter to receive the plunger 31 and an external diameter to engage within the plunger guide tube 21.
  • the plunger guide 36 acts purely as reinforcing for the fine plunger 31.
  • this syringe comprises a cylindical glass barrel 12 with an axial bore 13.
  • a needle bore 13 extends towards the inner end of the bore 13 from one end of the barrel [2 and the two bores 13 and 30 communicate by means of a thirdbore 41.
  • a needle 23 is resiliently secured in the needle bore 40 as previously described.
  • the plunger 31 is secured to the free end of a plunger guide 42 which is coaxial with the bore 13.
  • the plunger 31 extends through the third bore 41, through a resilient seal 40 into the needle bore 34.
  • the seal 40 is compressed between the end of the needle 23 and a shoulder 43 formed between the end of the needle bore 30 and the third bore 41.
  • the shoulder 43 may be of tapered form. as illustrated. or it may be substantially perpendicular to the barrel axis.
  • the plunger guide 42 which slides within the bore 13 provides the desired indication. in conjunction with graduations marked on the barrel. of delivered quantities of liquid. Further. the end of the bore 13 acts as a stop for the guide 42 to limit movement of the plunger 31 in the needle.
  • the syringe is provided with an adjustable stop 46 which is formed in two parts and clamped to the syringe barrel 12.
  • the stop 46 may be adjustably moved along the barrel and fastened thereto in any suitable position.
  • the stop 46 is provided with a bore 47 therethrough which is substantially parallel with the barrel axis.
  • a rod 48 is slidably mounted within the bore 47, the rod having one end thereof bent at right angles. as at 49, and adapted to engage in a transverse hole 51 formed in the syringe operating button 52 on the outer end of the plunger 31.
  • the other end of the rod 48 is formed with a shoulder 53 to limit outward movement of the rod 48 in the bore 47.
  • the stop 46 may be shaped with finger-engaging recesses 54 to facilitate use of the syringe.
  • the stop 46 is clamped on the barrel 12 at the location to limit outward movement of the plunger to give the desired measurement of liquid to be delivered.
  • the outward movement of the plunger 31 in the syringe is limited by engagement of the shoulder 53 with the stop 46.
  • the syringe may be dismantled by simply disconnecting the rod 48 from the hole 5] in the button.
  • this syringe has a relatively large diameter plunger this syringe has a capacity of up to 25 microliters with graduations of 0.5 microliters the needle must therefore be of correspondingly large diameter.
  • Such a large diameter needle has a large point and may tend to damage delicate membranes, septums and the like through which the needle must be passed.
  • the outer or entering end 61 of the needle is reduced to a diameter substantially less than that of the inner end of the needle, as illustrated in FIG. 4.
  • the entering end 61 may be electrolytically tapered and then ground to provide a relatively fine point with a reduced diameter bore 63.
  • the needle length is arranged so that the end of the plunger 31 stops at the reduced diameter probiscus 61.
  • a syringe comprising a barrel. a main bore in the barrel opening at one end thereof, a needle receiving bore in the other end of the barrel substantially coaxial with the main bore and communicating therewith. a hollow needle removably engaged in the needle receiving bore, a syringe plunger extending through the main bore and the needle receiving bore to precisely engage within the hollow needle, sealing means in said needle receiving bore and including a resilient seal through which the plunger slidably moves, and means holding the needle in the needle receiving bore with the inner end of the needle in sealing engagement with said resilient seal, said means comprising a threaded boss on the end of the barrel, an internally threaded nut engaged with the boss the nut having an aperture through which the needle extends, shoulder means on the needle and a tapered helical spring acting between the nut and the shoulder means to resiliently urge the needle into sealing engagement with the seal.
  • a syringe according to claim 1 wherein a plunger support tube is secured at one end in the needle receiv ing bore and extends through the main bore, said plunger being slidable in said support tube, and the resilient seal is disposed in the needle receiving bore between the end of the support tube and the end of the needle.
  • a syringe comprising a barrel, a main bore in the barrel opening at one end thereof, a needle receiving bore in the other end of the barrel substantially coaxial with the main bore and communicating therewith, a hollow needle removably engaged in the needle receiving bore, a syringe plunger extending through the main bore and the needle receiving bore to precisely engage within the hollow needle, sealing means in said needle receiving bore and including a resilient seal through which the plunger slidably moves, and means holding the needle in the needle receiving bore with the inner end of the needle in sealing engagement with said resilient seal
  • said means comprising a threaded boss on the end of the barrel, an internally threaded nut engaged with the boss the nut having an aperture through which the needle extends, shoulder means on the needle and resilient means acting between the nut and the shoulder means to resiliently urge the needle into sealing engagement with the seal, and secured to an operating button on the outer end of the plunger slidable in the main bore, the inner end of the sleeve engaging with the inner end of the main
  • a syringe comprising a barrel. a main bore in the barrel opening at one end thereof, a needle receiving bore in the other end ot'the barrel and an intermediate bore between the main bore and the needle receiving bore and coaxial therewith. the intermediate bore being of a diameter less than the diameter of both the main and needle receiving bores, a hollow needle in the needle receiving bore.
  • a syringe plunger extending through the main bore to engage within the hollow nee dle. the plunger having an inner section of a diameter to slidably engage the main bore and an outer section of a diameter to engage closely within the needle and the intermediate bore, a resilient.
  • annular seal in the needle receiving bore between the inner end of the needle and the inner end of the bore, and fastening means including a coil spring surrounding the needle and engaged with shoulder means on the needle and applying an axial force to urge resiliently the inner end of the needle into sealing engagement with the seal and compressing the seal against the inner end of the needle receiving bore.
  • a syringe according to claim 4 wherein a repetitive delivery assembly is mounted on the barrel and connected to the plunger, the assembly including a member adjustably clamped to the outer surface of the barrel, elongated rod means extending through a hole in the member parallel with the axis of the main bore, means connecting the outer end of the rod means to the plunger for axial movement therewith, and shoulder means on the other end of the rod means engageable with the member to limit outward movement of the plunger wherein the barrel has volume indicating graduations on its outer surface corresponding to axial positions of the plunger for various volumetric capacities of the syringe.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US399344A 1972-09-22 1973-09-20 Syringes for making precision volume measurements Expired - Lifetime US3921864A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPB053372 1972-09-22

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US3921864A true US3921864A (en) 1975-11-25

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US (1) US3921864A (cs)
AU (1) AU479960B2 (cs)
CH (1) CH562034A5 (cs)
DE (1) DE2347500A1 (cs)
GB (1) GB1444432A (cs)
NL (1) NL7313044A (cs)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4008718A (en) * 1976-02-26 1977-02-22 Isadore Pitesky Liquid filtering and dispensing assembly
US4165646A (en) * 1978-07-26 1979-08-28 Shapiro Justin J Adjustable micro-dispensing liquid pipet
US5052927A (en) * 1988-10-24 1991-10-01 Discko John Jr Syringe and disposable capsule with cannula for use therewith
US5951528A (en) * 1991-05-22 1999-09-14 Parkin; Adrian Hypodermic needles
WO1999065545A1 (en) * 1998-06-16 1999-12-23 Robbins Scientific Corporation Syringe with various needle assemblies
FR2783433A1 (fr) * 1998-09-18 2000-03-24 Delab Seringues pour l'administration de formulations pateuses ou semi-solides
US6364859B1 (en) 1998-06-16 2002-04-02 Robbins Scientific Corporation Locking cap for replaceable needle assembly
US20060129108A1 (en) * 2002-11-21 2006-06-15 Arzneimittel Gmbh Prefilled syringe
USD545429S1 (en) 2004-11-15 2007-06-26 Hays Janet C Calibrated medicine dispensing apparatus
US20070287958A1 (en) * 2004-01-12 2007-12-13 Iscience Surgical Corporation Injector for Viscous Materials
US20080262435A1 (en) * 2007-04-23 2008-10-23 Ultimed Inc. Low-dosage syringe
US20090247955A1 (en) * 2008-03-27 2009-10-01 Iscience Interventional Corporation Microliter injector
US20100217195A1 (en) * 2004-12-27 2010-08-26 Michael Emmert Needle for Bloodless IV
US20110155763A1 (en) * 2005-12-15 2011-06-30 Sogaro Alberto C Device For Retaining And Dispensing A Free-Flowing Substance
US11090445B2 (en) 2017-06-16 2021-08-17 Credence Medsystems, Inc. System and method for safety syringe
US11419991B2 (en) 2018-11-13 2022-08-23 Credence Medsystems, Inc. System and method for microdose injection
US11883635B2 (en) 2020-06-17 2024-01-30 Credence MedSystems System and method for microdose injection

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102018131603A1 (de) 2018-12-10 2020-06-10 Hitec Zang Gmbh Vorrichtung zum Dosieren von Chemikalien

Citations (6)

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Publication number Priority date Publication date Assignee Title
US1403020A (en) * 1920-12-06 1922-01-10 Everett Samuel James Hypodermic syringe
US2739589A (en) * 1954-10-25 1956-03-27 Donald E Yochem Hypodermic syringe gauge
US3216616A (en) * 1964-03-02 1965-11-09 Jr Homer Blankenship Syringe with upper and lower bores
US3401692A (en) * 1964-06-26 1968-09-17 Micro Tek Instr Corp Syringe provided with a lateral vent and having high compression seals within the syringe bore
US3677448A (en) * 1971-01-29 1972-07-18 Precision Sampling Corp Syringe with wire plunger for dispensing infinitesimally small, accurately measured quantities of fluid
US3815790A (en) * 1972-09-18 1974-06-11 Kensington Scient Corp Precision liquid pipetting devices

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1403020A (en) * 1920-12-06 1922-01-10 Everett Samuel James Hypodermic syringe
US2739589A (en) * 1954-10-25 1956-03-27 Donald E Yochem Hypodermic syringe gauge
US3216616A (en) * 1964-03-02 1965-11-09 Jr Homer Blankenship Syringe with upper and lower bores
US3401692A (en) * 1964-06-26 1968-09-17 Micro Tek Instr Corp Syringe provided with a lateral vent and having high compression seals within the syringe bore
US3677448A (en) * 1971-01-29 1972-07-18 Precision Sampling Corp Syringe with wire plunger for dispensing infinitesimally small, accurately measured quantities of fluid
US3815790A (en) * 1972-09-18 1974-06-11 Kensington Scient Corp Precision liquid pipetting devices

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4008718A (en) * 1976-02-26 1977-02-22 Isadore Pitesky Liquid filtering and dispensing assembly
US4165646A (en) * 1978-07-26 1979-08-28 Shapiro Justin J Adjustable micro-dispensing liquid pipet
US5052927A (en) * 1988-10-24 1991-10-01 Discko John Jr Syringe and disposable capsule with cannula for use therewith
US5336088A (en) * 1988-10-24 1994-08-09 Centrix, Inc. Syringe and disposable capsule and method of forming capsule with cannula
US5951528A (en) * 1991-05-22 1999-09-14 Parkin; Adrian Hypodermic needles
WO1999065545A1 (en) * 1998-06-16 1999-12-23 Robbins Scientific Corporation Syringe with various needle assemblies
US6364859B1 (en) 1998-06-16 2002-04-02 Robbins Scientific Corporation Locking cap for replaceable needle assembly
FR2783433A1 (fr) * 1998-09-18 2000-03-24 Delab Seringues pour l'administration de formulations pateuses ou semi-solides
WO2000016829A1 (fr) * 1998-09-18 2000-03-30 Societe De Conseils Et De Recherches D'applications Scientifiques (S.C.R.A.S.) Seringues pour l'administration de formulations pateuses ou semi-solides
US7713244B1 (en) 1998-09-18 2010-05-11 Societe De Conseils De Recherches Et D'applications Scientifiques Scras Syringes for administering pasty or semi-solid formulations
US7645267B2 (en) * 2002-11-21 2010-01-12 Arzneimittel Gmbh Prefilled syringe
US20060129108A1 (en) * 2002-11-21 2006-06-15 Arzneimittel Gmbh Prefilled syringe
US20070287958A1 (en) * 2004-01-12 2007-12-13 Iscience Surgical Corporation Injector for Viscous Materials
US7967772B2 (en) 2004-01-12 2011-06-28 Iscience Interventional Corporation Injector for viscous materials
USD545429S1 (en) 2004-11-15 2007-06-26 Hays Janet C Calibrated medicine dispensing apparatus
US8182448B2 (en) * 2004-12-27 2012-05-22 Michael Emmert Needle for bloodless IV
US20100217195A1 (en) * 2004-12-27 2010-08-26 Michael Emmert Needle for Bloodless IV
US10406328B2 (en) 2004-12-27 2019-09-10 Blivic, Llc Needle for bloodless IV
US20110155763A1 (en) * 2005-12-15 2011-06-30 Sogaro Alberto C Device For Retaining And Dispensing A Free-Flowing Substance
US8197448B2 (en) * 2005-12-15 2012-06-12 Sulzer Mixpac Ag Device for retaining and dispensing a free-flowing substance
US20080262435A1 (en) * 2007-04-23 2008-10-23 Ultimed Inc. Low-dosage syringe
US8529521B2 (en) * 2007-04-23 2013-09-10 Ultimed Inc. Low-dosage syringe
US20090247955A1 (en) * 2008-03-27 2009-10-01 Iscience Interventional Corporation Microliter injector
US11090445B2 (en) 2017-06-16 2021-08-17 Credence Medsystems, Inc. System and method for safety syringe
US11964141B2 (en) 2017-06-16 2024-04-23 Credence Medsystems, Inc. System and method for safety syringe
US11419991B2 (en) 2018-11-13 2022-08-23 Credence Medsystems, Inc. System and method for microdose injection
US12329953B2 (en) 2018-11-13 2025-06-17 Credence Medsystems, Inc. System and method for multiple site injection
US11883635B2 (en) 2020-06-17 2024-01-30 Credence MedSystems System and method for microdose injection

Also Published As

Publication number Publication date
GB1444432A (en) 1976-07-28
NL7313044A (cs) 1974-03-26
DE2347500A1 (de) 1974-04-11
AU479960B2 (en) 1977-01-11
AU6058973A (en) 1975-03-27
CH562034A5 (cs) 1975-05-30

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